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In continuation of the search for potential analgesics amongst 4-hydroxyquinol-2-one derivatives we have proposed and carried out a preparative method of synthesis of 4-hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid alkylamides. It has been shown that bromination of 4-hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid allylamide using an equivalent of molecular bromine occurs with a conventional addition of the halogen to the allyl double bond and not with halocyclization. The results of the study of the analgesic properties of the compounds prepared are presented.
| Authors: | I. V. Ukrainets, O. V. Bevz, E. V. Mospanova, L. V. Savchenkova, S. I. Yankovich | |
| Journal: | Chemistry of Heterocyclic Compounds | |
| Year: | 2012 | |
| DOI: | 10.1007/s10593-012-0992-4 | |
| Publication date: | 04-06-2012 |
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