Three novel transition metal coordination complexes, Cu(C18H16N3O2)2·2CH3OH (1), Zn(C18H16N3O2)2·2CH3CH2OH (2) and Cd(C18H16N3O2)2·2CH3OH (3) (C18H16N3O2: 2-acetylpyridine-L-tryptophan) have been synthesized and characterized by IR, UV, elemental analysis, 1H NMR and X-ray diffraction single crystal analysis. The three crystals crystallize in the tetragonal crystal system, space group P43212. They are all six-coordinated by two nitrogen atoms from C=N, two nitrogen atoms from pyridine rings and two carboxylic oxygen atoms in different ligands, forming a distorted octahedron geometry. Each ligand serves as a bridging ligand to link metal ions through carboxylic oxygen atoms, leading to a three-dimensional coordination polymer. The anticancer activities of these three complexes on MDA-MB-231 breast cancer cells were also investigated. The results indicate that all of the three complexes can inhibit the cellular proliferation. Furthermore, Cd(C18H16N3O2)2·2CH3OH (3) has the highest anti-proliferative activity among the three complexes. In addition, Cd(C18H16N3O2)2·2CH3OH (3) can inhibit proteasomal chymotrypsin-like activity and also can induce apoptosis on human breast cancer MDA-MB-231 cells.
Cellular morphological changes of MDA-MB-231 cells treated with Cd(C18H16N3O2)2·2CH3OH (3) for 24h.
►Cu(II), Zn(II) and Cd(II) coordination polymers with Schiff bases were synthesized. ►The crystal structures of the three coordination polymers were determined. ►The anticancer activity of the Cd(II) coordination polymer was studied.
Nan Zhang, Yu-hua Fan, Zhen Zhang, Jian Zuo, Peng-fei Zhang, Qiang Wang, Shan-bin Liu, Cai-feng Bi
Publication date: July 2013Source:Journal of Solid State Chemistry, Volume 203 Author(s): S. Kumar , K. Singh , M. Miclau , Ch. Simon , C. Martin , A. Maignan The change from antiferromagnetism induced ferroelectricity to spin glass ferroelectric relaxor has been studied along the ... more
Publication date: July 2013Source:Journal of Solid State Chemistry, Volume 203 Author(s): Brian B. Kitchen , Nina Verdal , Terrence J. Udovic , John J. Rush , Michael R. Hartman , Daniel J. DeVries To investigate the previously reported low-temperature phase transition in rubidium ... more
Publication date: July 2013Source:Journal of Solid State Chemistry, Volume 203 Author(s): T. Sasikala , L. Rama Moorthy , A. Mohan Babu , T. Srinivasa Rao The present work reports the absorption, photoluminescence and decay properties of singly doped Dy3+ and co-doped Dy3+/Tm3+ ions ... more
Elsevier announced the acquisition through its subsidiary MDL Information Systems GmbH, of the Beilstein Database, the world's largest compilation of chemical facts and the premier database in the field of organic chemistry.
Elsevier has been exclusively involved in both the production an ... more