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Abstract:
We herein document the discovery of 5-arylidene-2,2-dimethyl-1,3-dioxane-4,6-diones as a novel family of platelet aggregation inhibitors. The preliminary optimization study enabled us to establish the most salient features of the structure-activity relationships in this series as well as to identify novel derivatives that are upto 60 times more potent than the hit structure 1 and slightly superior to the reference drug Milrinone.| Authors: | El Maatougui, Abdelaziz; JhonnyAzuaje,; Coelho, Alberto; Cano, Ernesto; Yanez, Matilde; Lopez, Carmen; Yaziji, Vicente; Carbajales, Carlos; Sotelo, Eddy | |
| Journal: | Combinatorial Chemistry | |
| DOI: | 10.2174/138620712801619122 |
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