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A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome [Medical Sciences]

09-Dec-2014 | Simin Lu; Kohsuke Kanekura; Takashi Hara; Jana Mahadevan; Larry D. Spears; Christine M. Oslowski; Rita Martinez; May ..., Proceedings of the National Academy of Sciences current issue, 2014

Wolfram syndrome is a genetic disorder characterized by diabetes and neurodegeneration and considered as an endoplasmic reticulum (ER) disease. Despite the underlying importance of ER dysfunction in Wolfram syndrome and the identification of two causative genes, Wolfram syndrome 1 (WFS1) and ...

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High-Resolution Enabled 12-Plex DiLeu Isobaric Tags for Quantitative Proteomics

08-Dec-2014 | Dustin C. Frost; Tyler Greer; Lingjun Li, Analytical Chemistry, 2014

Multiplex isobaric tags (e.g., tandem mass tags (TMT) and isobaric tags for relative and absolute quantification (iTRAQ)) are a valuable tool for high-throughput mass spectrometry based quantitative proteomics. We have developed our own multiplex isobaric tags, DiLeu, that feature quantitative ...

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Improvement of Shotgun Proteomics in the Negative Mode by Carbamylation of Peptides and Ultraviolet Photodissociation Mass Spectrometry

05-Dec-2014 | Sylvester M. Greer; Joe R. Cannon; Jennifer S. Brodbelt, Analytical Chemistry, 2014

Although acidic peptides compose a substantial portion of many proteomes, their less efficient ionization during positive polarity electrospray ionization (ESI) impedes their detection in bottom-up mass spectrometry workflows. We have implemented a derivatization strategy based on carbamylation ...

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Relative quantification of amine-containing metabolites using isobaric N,N-dimethyl leucine (DiLeu) reagents via LC-ESI-MS/MS and CE-ESI-MS/MS

03-Dec-2014 | Ling Hao; Xuefei Zhong; Tyler Greer; Hui Ye; Lingjun Li, Analyst, 2014

Tandem mass spectrometry (MS/MS)-based relative quantification by isobaric labeling is a useful technique to compare different metabolic expression levels in biological systems. For the first time, we have labeled primary and secondary amine-containing small molecules using 4-plex isobaric ...

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Relative quantification of amine-containing metabolites using isobaric N,N-dimethyl-leucine (DiLeu) reagents via LC-ESI-MS/MS and CE-ESI-MS/MS

26-Nov-2014 | Ling Hao; Xuefei Zhong; Tyler Greer; Hui Ye; Lingjun Li, Analyst, 2014

Tandem mass spectrometry (MS/MS)-based relative quantification by isobaric labeling is a useful technique to compare different metabolic expression levels in biological systems. For the first time, we have labeled primary and secondary amine-containing small molecules using 4-plex isobaric ...

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Nonsensory target-dependent organization of piriform cortex [Neuroscience]

25-Nov-2014 | Chien-Fu F. Chen; Dong-Jing Zou; Clara G. Altomare; Lu Xu; Charles A. Greer; Stuart J. Firestein, Proceedings of the National Academy of Sciences current issue, 2014

The piriform cortex (PCX) is the largest component of the olfactory cortex and is hypothesized to be the locus of odor object formation. The distributed odorant representation found in PCX contrasts sharply with the topographical representation seen in other primary sensory cortices, making it ...

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Development of a Planar Waveguide Microarray for the Monitoring and Early Detection of Five Harmful Algal Toxins in Water and Cultures

31-Oct-2014 | Sara E. McNamee; Christopher T. Elliott; Brett Greer; Michael Lochhead; Katrina Campbell, Environmental Science & Technology, 2014

A novel multiplex microarray has been developed for the detection of five groups of harmful algal and cyanobacterial toxins found in marine, brackish, and freshwater environments including domoic acid (DA), okadaic acid (OA, and analogues), saxitoxin (STX, and analogues), cylindrospermopsin (CYN) ...

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Effect of structure on electronic properties of the iron-carbon nanotube interface

12-Oct-2014 | Author(s): Sarah L.T. Jones , Gabriel Greene-Diniz , Michael Haverty , Sadasivan Shankar , James C. Greer, Chemical Physics Letters, 2014

Publication date: 5 November 2014 Source:Chemical Physics Letters, Volume 615 Author(s): Sarah L.T. Jones , Gabriel Greene-Diniz , Michael Haverty , Sadasivan Shankar , James C. Greer...

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Zeolites with Continuously Tuneable Porosity

06-Oct-2014 | Paul S. Wheatley, Pavla Chlubná‐Eliášová, Heather Greer, Wuzong Zhou, Valerie R. Seymour, Daniel M. Dawson, Sharon E ..., Angewandte Chemie International Edition, 2014

Abstract Zeolites are important materials whose utility in industry depends on the nature of their porous structure. Control over microporosity is therefore a vitally important target. Unfortunately, traditional methods for controlling porosity, in particular the use of organic ...

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Olfactory learning promotes input-specific synaptic plasticity in adult-born neurons [Neuroscience]

23-Sep-2014 | Gabriel Lepousez; Antoine Nissant; Alex K. Bryant; Gilles Gheusi; Charles A. Greer; Pierre-Marie Lledo, Proceedings of the National Academy of Sciences current issue, 2014

The production of new neurons in the olfactory bulb (OB) through adulthood is a major mechanism of structural and functional plasticity underlying learning-induced circuit remodeling. The recruitment of adult-born OB neurons depends not only on sensory input but also on the context in which the ...

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