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Marine natural products

09-Feb-2016 | John W. Blunt; Brent R. Copp; Robert A. Keyzers; Murray H. G. Munro; Michèle R. Prinsep, Natural Product Reports, 2016

Covering: 2014. Previous review: Nat. Prod. Rep., 2015, 32, 116–211 This review covers the literature published in 2014 for marine natural products (MNPs), with 1116 citations (753 for the period January to December 2014) referring to compounds isolated from marine microorganisms and ...

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Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere

05-Feb-2016 | Benjamin A. Chalmers, Hui Xing, Sevan Houston, Charlotte Clark, Sussan Ghassabian, Andy Kuo, Benjamin Cao, Andrea Re ..., Angewandte Chemie International Edition, 2016

Abstract Pharmaceutical and agrochemical discovery programs are under considerable pressure to meet increasing global demand and thus require constant innovation. Classical hydrocarbon scaffolds have long assisted in bringing new molecules to the market place, but an obvious omission is that ...

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Discovery of Narrow Spectrum Kinase Inhibitors: New Therapeutic Agents for the Treatment of COPD and Steroid-Resistant Asthma

04-Feb-2016 | Stuart T. Onions; Kazuhiro Ito; Catherine E. Charron; Richard J. Brown; Marie Colucci; Fritz Frickel; George Hardy; ..., Journal of Medicinal Chemistry, 2016

Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.5b01029

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Induction of Calcium Influx in Cortical Neural Networks by Nanomagnetic Forces

28-Jan-2016 | Andy Tay; Anja Kunze; Coleman Murray; Dino Di Carlo, ACS Nano, 2016

Nanomagnetic force stimulation with ferromagnetic nanoparticles was found to trigger calcium influx in cortical neural networks without observable cytotoxicity. Stimulated neural networks showed an average of 20% increment in calcium fluorescence signals and a heightened frequency in calcium ...

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Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants

28-Jan-2016 | Hengmiao Cheng; Sajiv K. Nair; Brion W. Murray; Chau Almaden; Simon Bailey; Sangita Baxi; Doug Behenna; Sujin Cho-Sc ..., Journal of Medicinal Chemistry, 2016

First generation EGFR TKIs (gefitinib, erlotinib) provide significant clinical benefit for NSCLC cancer patients with oncogenic EGFR mutations. Ultimately, these patients’ disease progresses, often driven by a second-site mutation in the EGFR kinase domain (T790M). Another liability of the first ...

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Probing Atomic Positions of Ammonia Molecules In Zeolite

26-Jan-2016 | Edman Tsang; Lin Ye; Ben Tsz Lo; Jin Qu; Ian Wilkinson; Tim Hughes; Claire Murray; Chiu Tang, Chemical Communication, 2016

Molecular species can be captured in microporous zeolites. However, due the lack of generic method to characterize their adsorption structure at atomic level, poor understanding on fundamental interaction(s) between adsorbate-adsorbate and with internal solid surfaces is obtained. Typically, ...

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Heteronuclear Ni(II)-Ln(III) (Ln = La, Pr, Tb, Dy) complexes: Synthesis and Single-Molecule Magnet Behaviour

19-Jan-2016 | Maheswaran Shanmugam; Apoorva Upadhyay; Chinmoy Das; Stuart Langley; Keith S. Murray; Anant Kumar Srivastava, Dalton Transactions, 2016

The reaction of hydrated nickel(II) salts (chloride or nitrate) and various hydrated lanthanide nitrate salts with the Schiff base ligand 2-methoxy-6-[(E)-phenyliminomethyl] phenol (HL) in methanol resulted in the isolation of three isostructural linear heterometallic trinuclear complexes and a ...

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NeutrAvidin Functionalization of CdSe/CdS Quantum Nanorods and Quantification of Biotin Binding Sites using Biotin-4-Fluorescein Fluorescence Quenching

14-Jan-2016 | Lisa G. Lippert; Jeffrey T. Hallock; Tali Dadosh; Benjamin T. Diroll; Christopher B. Murray; Yale E. Goldman, Bioconjugate Chemistry, 2016

We developed methods to solubilize, coat, and functionalize with NeutrAvidin elongated semiconductor nanocrystals (quantum nanorods, QRs) for use in single molecule polarized fluorescence microscopy. Three different ligands were compared with regard to efficacy for attaching NeutrAvidin using the ...

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Functional hierarchy underlies preferential connectivity disturbances in schizophrenia [Neuroscience]

12-Jan-2016 | Genevieve J. Yang; John D. Murray; Xiao-Jing Wang; David C. Glahn; Godfrey D. Pearlson; Grega Repovs; John H. Krysta ..., Proceedings of the National Academy of Sciences current issue, 2016

Schizophrenia may involve an elevated excitation/inhibition (E/I) ratio in cortical microcircuits. It remains unknown how this regulatory disturbance maps onto neuroimaging findings. To address this issue, we implemented E/I perturbations within a neural model of large-scale functional ...

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Synthesis and Size-Selective Precipitation of Monodisperse Nonstoichiometric MxFe3–xO4 (M = Mn, Co) Nanocrystals and Their DC and AC Magnetic Properties

12-Jan-2016 | Dichen Li; Hongseok Yun; Benjamin T. Diroll; Vicky V. T. Doan-Nguyen; James M. Kikkawa; Christopher B. Murray, Chemistry of Materials, 2016

Spinel ferrite nanocrystals (NCs) have shown great promise for a wide variety of electromagnetic and medical applications. In this work, the AC magnetic properties of nonstoichiometric manganese and cobalt ferrites (MxFe3–xO4, M = Mn, Co) NCs are systematically studied as a function of ...

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