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Endothelial heparan sulfate deficiency reduces inflammation and fibrosis in murine diabetic nephropathy

12-Jan-2018 | Ditmer T. Talsma; Kirankumar Katta; Marieke A. B. Ettema; Berna Kel; Marion Kusche-Gullberg; Moh R. Daha; Coen A. St ..., Laboratory Investigation, 2018

Inflammation plays a vital role in the development of diabetic nephropathy, but the underlying regulatory mechanisms are only partially understood. Our previous studies demonstrated that, during acute inflammation, endothelial heparan sulfate (HS) contributes to the adhesion and transendothelial ...

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Endothelial heparan sulfate deficiency reduces inflammation and fibrosis in murine diabetic nephropathy

12-Jan-2018 | Ditmer T. Talsma; Kirankumar Katta; Marieke A. B. Ettema; Berna Kel; Marion Kusche-Gullberg; Moh R. Daha; Coen A. St ..., Laboratory Investigation, 2018

Inflammation plays a vital role in the development of diabetic nephropathy, but the underlying regulatory mechanisms are only partially understood. Our previous studies demonstrated that, during acute inflammation, endothelial heparan sulfate (HS) contributes to the adhesion and transendothelial ...

more

SLC26A3 (DRA) prevents TNF-alpha-induced barrier dysfunction and dextran sulfate sodium-induced acute colitis

12-Jan-2018 | Xiangming Ding; Dongxiao Li; Mengke Li; Han Wang; Qin He; Yunwu Wang; Hongbing Yu; Dean Tian; Qin Yu, Laboratory Investigation, 2018

SLC26A3 encodes a Cl−/HCO3− ion transporter that is also known as downregulated in adenoma (DRA) and is involved in HCO3−/mucus formation. The role of DRA in the epithelial barrier has not been previously established. In this study, we investigated the in vivo and in vitro mechanisms of DRA in ...

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SLC26A3 (DRA) prevents TNF-alpha-induced barrier dysfunction and dextran sulfate sodium-induced acute colitis

12-Jan-2018 | Xiangming Ding; Dongxiao Li; Mengke Li; Han Wang; Qin He; Yunwu Wang; Hongbing Yu; Dean Tian; Qin Yu, Laboratory Investigation, 2018

SLC26A3 encodes a Cl−/HCO3− ion transporter that is also known as downregulated in adenoma (DRA) and is involved in HCO3−/mucus formation. The role of DRA in the epithelial barrier has not been previously established. In this study, we investigated the in vivo and in vitro mechanisms of DRA in ...

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β-Ecdysterone protects SH-SY5Y cells against β-amyloid-induced apoptosis via c-Jun N-terminal kinase- and Akt-associated complementary pathways

12-Jan-2018 | Tianjiao Xu; Chengu Niu; Xiaojie Zhang; Miaoxian Dong, Laboratory Investigation, 2018

Recently, the significantly higher incidence of Alzheimer’s disease (AD) in women than in men has been attributed to the loss of neuroprotective estrogen after menopause. Does phytoestrogen have the ability to protect against amyloid-β (Aβ) toxicity? The aim of this study was to evaluate ...

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Amyloid deposition in a mouse model humanized at the transthyretin and retinol-binding protein 4 loci

12-Jan-2018 | Xiangshun Li; Yanyi Lyu; Jingling Shen; Yanshuang Mu; Lixia Qiang; Li Liu; Kimi Araki; Bruno P. Imbimbo; Ken-ichi Ya ..., Laboratory Investigation, 2018

Familial amyloidotic polyneuropathy is an autosomal dominant disorder caused by a point mutation in the transthyretin (TTR) gene. The process of TTR amyloidogenesis begins with rate-limiting dissociation of the TTR tetramer. Thus, the TTR stabilizers, such as Tafamidis and Diflunisal, are now in ...

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Severe steatosis induces portal hypertension by systemic arterial hyporeactivity and hepatic vasoconstrictor hyperreactivity in rats

11-Jan-2018 | Denise Graaff; Wilhelmus J Kwanten; Filip J Couturier; Jesse S Govaerts; Wim Verlinden; Isabel Brosius; Michiel D ..., Laboratory Investigation, 2018

Non-alcoholic fatty liver disease (NAFLD) has become the most prevalent chronic liver disease. The presence of portal hypertension has been demonstrated in NAFLD prior to development of inflammation or fibrosis, and is a result of extrahepatic and intrahepatic factors, principally driven by ...

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Microscale characterization of prostate biopsies tissues using optical coherence elastography and second harmonic generation imaging

18-Dec-2017 | Ling Yuting; Chunhui Li; Kanheng Zhou; Guangying Guan; Paul L Appleton; Stephen Lang; David McGloin; Zhihong Huang; ..., Laboratory Investigation, 2017

Microscale characterization of prostate biopsies tissues using optical coherence elastography and second harmonic generation imaging Microscale characterization of prostate biopsies tissues using optical coherence elastography and second harmonic generation imaging, Published online: 18 December ...

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PGE2 EP1 receptor inhibits vasopressin-dependent water reabsorption and sodium transport in mouse collecting duct

18-Dec-2017 | Rania Nasrallah; Joseph Zimpelmann; David Eckert; Jamie Ghossein; Sean Geddes; Jean-Claude Beique; Jean-Francois Thi ..., Laboratory Investigation, 2017

PGE2 EP1 receptor inhibits vasopressin-dependent water reabsorption and sodium transport in mouse collecting duct PGE2 EP1 receptor inhibits vasopressin-dependent water reabsorption and sodium transport in mouse collecting duct, Published online: 18 December 2017; ...

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NM23 proteins: innocent bystanders or local energy boosters for CFTR?

18-Dec-2017 | Richmond Muimo; Hani MM Alothaid; Anil Mehta, Laboratory Investigation, 2017

NM23 proteins: innocent bystanders or local energy boosters for CFTR? NM23 proteins: innocent bystanders or local energy boosters for CFTR?, Published online: 18 December 2017; doi:10.1038/labinvest.2017.121 NM23 proteins: innocent bystanders or local energy boosters for CFTR?

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