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462 Newest Publications from the industry lab technology

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A humanized mouse model of liver fibrosis following expansion of transplanted hepatic stellate cells

19-Jan-2018 | Daniel Benten; Johannes Kluwe; Jan W. Wirth; Nina D. Thiele; Antonia Follenzi; Kuldeep K. Bhargava; Christopher J. P ..., Laboratory Investigation, 2018

Hepatic stellate cells (HSCs) are major contributors to liver fibrosis, as hepatic injuries may cause their transdifferentiation into myofibroblast-like cells capable of producing excessive extracellular matrix proteins. Also, HSCs can modulate engraftment of transplanted hepatocytes and ...

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An in vitro system of autologous lymphocytes culture that allows the study of homeostatic proliferation mechanisms in human naive CD4 T-cells

18-Jan-2018 | Isaac Rosado-Sánchez; Amaia González-Magaña; María M Pozo-Balado; Inés Herrero-Fernánd ..., Laboratory Investigation, 2018

The size of peripheral T-cell pool is kept constant throughout life. However, a decline in lymphocyte numbers is a feature of several human disorders, in which fast and slow homeostatic proliferation play a crucial role. Several in vitro and in vivo models have been developed to study such ...

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Disruption of CXCR3 function impedes the development of Sjögren’s syndrome-like xerostomia in non-obese diabetic mice

18-Jan-2018 | Jing Zhou; Qing Yu, Laboratory Investigation, 2018

The chemokine receptor CXCR3 plays an important role in T cell recruitment in various immune responses and autoimmune diseases. Expression of CXCR3 ligands, including CXCL9, CXCL10, and CXCL11, is elevated in the salivary glands of patients with Sjögren’s syndrome (SS). To elucidate whether ...

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Inhibition of WNT/β-catenin signaling under serum starvation and hypoxia induces adipocytic transdifferentiation in human leiomyoma cells

18-Jan-2018 | Hiroshi Harada; Yojiro Tsuda; Kei Yabuki; Eisuke Shiba; Kazuyoshi Uchihashi; Atsuji Matsuyama; Yoshihisa Fujino; Tor ..., Laboratory Investigation, 2018

Fatty metamorphosis is an uncommon alteration in uterine leiomyoma (i.e., lipoleiomyoma), and the pathogenetic mechanisms underlying this phenomenon remain poorly understood. Because a conditional deletion of β-catenin, a major transducer of the canonical Wingless/integrated (WNT) pathway, in the ...

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The role of metabolic enzymes in mesenchymal tumors and tumor syndromes: genetics, pathology, and molecular mechanisms

16-Jan-2018 | Inga-Marie Schaefer; Jason L. Hornick; Judith V. M. G. Bovée, Laboratory Investigation, 2018

The discovery of mutations in genes encoding the metabolic enzymes isocitrate dehydrogenase (IDH), succinate dehydrogenase (SDH), and fumarate hydratase (FH) has expanded our understanding not only of altered metabolic pathways but also epigenetic dysregulation in cancer. IDH1/2 mutations occur ...

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The ‘known-knowns’, and ‘known-unknowns’ of extracellular Nm23-H1/NDPK proteins

16-Jan-2018 | Chris M. Bunce; Farhat L. Khanim, Laboratory Investigation, 2018

Nucleoside diphosphate kinases (NDPKs/NDK/NME) are a multifunctional class of proteins conserved throughout evolution. Whilst many of the functions of NDPKs have been identified as intracellular, extracellular eukaryotic and prokaryotic NDPK proteins are also detected in multiple systems and have ...

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Obtaining high quality transcriptome data from formalin-fixed, paraffin-embedded diagnostic prostate tumor specimens

16-Jan-2018 | Liesel M. FitzGerald; Chol-hee Jung; Ee Ming Wong; JiHoon E. Joo; Jodee A. Gould; Vivien Vasic; Julie K. Bassett; Ne ..., Laboratory Investigation, 2018

Prognostic genomic biomarkers that can be measured at diagnosis to aid choice of treatment options are unavailable for most common cancers. This is due in part to the poor quality and quantity of available diagnostic specimens for discovery research and to limitations in genomic technologies. ...

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Use of multicolor fluorescence in situ hybridization to detect deletions in clinical tissue sections

16-Jan-2018 | Maisa Yoshimoto; Olga Ludkovski; Jennifer Good; Ciro Pereira; Robert J. Gooding; Jean McGowan-Jordan; Alexander Boag ..., Laboratory Investigation, 2018

A variety of laboratory methods are available for the detection of deletions of tumor suppressor genes and losses of their proteins. The clinical utility of fluorescence in situ hybridization (FISH) for the identification of deletions of tumor suppressor genes has previously been limited by ...

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Endothelial heparan sulfate deficiency reduces inflammation and fibrosis in murine diabetic nephropathy

12-Jan-2018 | Ditmer T. Talsma; Kirankumar Katta; Marieke A. B. Ettema; Berna Kel; Marion Kusche-Gullberg; Moh R. Daha; Coen A. St ..., Laboratory Investigation, 2018

Inflammation plays a vital role in the development of diabetic nephropathy, but the underlying regulatory mechanisms are only partially understood. Our previous studies demonstrated that, during acute inflammation, endothelial heparan sulfate (HS) contributes to the adhesion and transendothelial ...

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Endothelial heparan sulfate deficiency reduces inflammation and fibrosis in murine diabetic nephropathy

12-Jan-2018 | Ditmer T. Talsma; Kirankumar Katta; Marieke A. B. Ettema; Berna Kel; Marion Kusche-Gullberg; Moh R. Daha; Coen A. St ..., Laboratory Investigation, 2018

Inflammation plays a vital role in the development of diabetic nephropathy, but the underlying regulatory mechanisms are only partially understood. Our previous studies demonstrated that, during acute inflammation, endothelial heparan sulfate (HS) contributes to the adhesion and transendothelial ...

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