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2,373 Newest Publications in analytical and bioanalytical chemistry
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Investigation of the metabolism of monepantel in ovine hepatocytes by UHPLC/MS/MS
27-11-2012 | Lucie Stuchlíková, Robert Jirásko, Ivan Vokřál, Jiří Lamka, Marcel Špulák, Michal Holčapek, Barbora Szotáková, Hana ..., Analytical and Bioanalytical Chemistry, 2012
Monepantel (MOP) belongs to a new class of anthelmintic drugs known as aminoacetonitrile derivatives. It was approved for use in veterinary practice in Czech Republic in 2011. So far, biotransformation and transport of MOP in target animals have been studied insufficiently, although the study ...
Characterization of the alkaloids in goldenseal (Hydrastis canadensis) root by high resolution Orbitrap LC-MSn
25-11-2012 | Phuong Mai Le, Margaret McCooeye, Anthony Windust, Analytical and Bioanalytical Chemistry, 2012
Liquid chromatography coupled to multistage mass spectrometry (LC-MSn) is being used increasingly in pharmaceutical research and for quality control in herbal medicines because of its superior sensitivity and selectivity. In this study, a rapid, high-resolution liquid chromatography-mass ...
Optimizing hollow-fiber-based pharmacokinetic assay via chemical stability study to account for inaccurate simulated drug clearance of rifampicin
25-11-2012 | Lee Sun New, Tze Peng Lim, Jing Wen Oh, Gavin Jia Sheng Cheah, Andrea L. Kwa, Eric Chun Yong Chan, Analytical and Bioanalytical Chemistry, 2012
With increasing multidrug resistance coupled to a poor development pipeline, clinicians are exploring antimicrobial combinations to improve treatment outcomes. In vitro hollow-fiber infection model (HFIM) is employed to simulate human in vivo drug clearance and investigate pharmacodynamic ...
Populus nigra L. bud absolute: a case study for a strategy of analysis of natural complex substances
25-11-2012 | Patrizia Rubiolo, Cristina Casetta, Cecilia Cagliero, Hugues Brevard, Barbara Sgorbini, Carlo Bicchi, Analytical and Bioanalytical Chemistry, 2012
The new European regulations (e.g., REACH) require that Natural Complex Substances such as essential oils, absolutes, concretes, and resinoids are registered. This need implies that the chemical composition of these complex mixtures is characterized as exhaustively as possible in view of ...
Determination of 32 cathinone derivatives and other designer drugs in serum by comprehensive LC-QQQ-MS/MS analysis
25-11-2012 | Madeleine J. Swortwood, Diane M. Boland, Anthony P. DeCaprio, Analytical and Bioanalytical Chemistry, 2012
Recently, clandestine drug lab operators have attempted to bypass controlled substances laws and regulations with “designer” compounds chemically and pharmacologically similar to controlled substances. For example, “bath salts” have erupted onto the scene as “legal highs” containing cathinone ...
Ambient analysis by thermal desorption atmospheric pressure photoionization
25-11-2012 | Kaveh Jorabchi, Karl Hanold, Jack Syage, Analytical and Bioanalytical Chemistry, 2012
Ambient mass spectrometry has attracted substantial attention in recent years. Among ambient ionization methods, thermal desorption ionization stands out because of two attributes: (1) simplicity, rendering the technique suitable for in-field applications, and (2) ability to couple with a ...
Development, optimization, and use of an APCI source with temperature-controlled vaporization of solid and liquid samples
25-11-2012 | Sonja Krieger, Alexandra von Trotha, Kelvin Sze-Yin Leung, Oliver J. Schmitz, Analytical and Bioanalytical Chemistry, 2012
A trend is observed in mass spectrometry, in which solid samples without prior dissolution and chromatographic separation are brought directly into the ion source and are ionized, e.g., by corona discharge (Atmospheric Solids Analysis Probe) or plasma (Direct Analysis in Real Time). The ...
Effects of the expression level of epidermal growth factor receptor on the ligand-induced restructuring of focal adhesions: a QCM-D study
25-11-2012 | Marcela P. Garcia, Ammar Shahid, Jennifer Y. Chen, Jun Xi, Analytical and Bioanalytical Chemistry, 2012
Epidermal growth factor receptor (EGFR) plays a major role in cell migration and invasion and is considered to be the primary source of activation of various malignant tumors. To gain insight into how elevated levels of EGFR influence cellular function, particularly cell motility, we used a ...
Detection of flagellin by interaction with human recombinant TLR5 immobilized in liposomes
25-11-2012 | Y. Olguín, P. Villalobos, L. G. Carrascosa, M. Young, E. Valdez, L. Lechuga, R. Galindo, Analytical and Bioanalytical Chemistry, 2012
Digestive diseases caused by flagellated bacteria are a huge public health problem worldwide and rapid detection methods are needed for contaminated environments. In this study, we propose a method to detect patterns associated with pathogens based on the properties of the innate immune ...
Copper and tin isotopic analysis of ancient bronzes for archaeological investigation: development and validation of a suitable analytical methodology
25-11-2012 | Eleonora Balliana, Maite Aramendía, Martin Resano, Carlo Barbante, Frank Vanhaecke, Analytical and Bioanalytical Chemistry, 2012
Although in many cases Pb isotopic analysis can be relied on for provenance determination of ancient bronzes, sometimes the use of “non-traditional” isotopic systems, such as those of Cu and Sn, is required. The work reported on in this paper aimed at revising the methodology for Cu and Sn ...
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