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198 Newest Publications in biochemistry supplemental series b: biomedical chemistry
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Functional activity of the NADH-dependent reductase system in liver and Guerin’s carcinoma microsomal fraction in rats exposed to preliminary irradiation
14-11-2012 | M. M. Marchenko, O. V. Ketsa, Biochemistry Supplemental Series B: Biomedical Chemistry, 2012
The activity of liver microsomal and Guerin’s carcinoma NADH-cytochrome b 5 reductase, the content and the rate of cytochrome b 5 oxidation-reduction have been investigated in tumor-bearing rats exposed to preliminary irradiation. Preliminary irradiation of rats (before transplantation of ...
The dose-dependent effect of 3,5-dicarbomethoxyphenylbiguanide on activity of the glutathione antioxidant system in heart and blood serum of rats with experimental myocardial infarction
14-11-2012 | E. S. Tanygina, T. N. Popova, A. V. Semenikhina, L. V. Matasova, E. D. Kryl’skiy, Biochemistry Supplemental Series B: Biomedical Chemistry, 2012
Administration of a synthetic compound with predicted anti-ischemic and cardioprotective activity, 3,5-dicarbomethoxyphenylbiguanide (3,5-DCMPBG) to rats with experimental myocardial infarction led to a decrease in the lipid peroxidation level, glutathione peroxidase activity, the level of ...
Antitumor activity of L-asparaginase from Erwinia carotovora against different human and animal leukemic and solid tumor cell lines
14-11-2012 | O. Yu. Abakumova, O. V. Podobed, P. A. Karalkin, L. I. Kondakova, N. N. Sokolov, Biochemistry Supplemental Series B: Biomedical Chemistry, 2012
The dose- and time-dependent antitumor and cytotoxic effects of L-asparaginases from Erwinia carotovora (ECAR LANS) and Escherichia coli (MEDAC) have been investigated using human leukemic cells and human and animal solid tumor cells. These included human T-cell acute lymphoblastic leukemia ...
Mass spectrometry detection of monomeric renalase in human urine
14-11-2012 | V. I. Fedchenko, O. A. Buneeva, A. T. Kopylov, A. A. Kaloshin, L. N. Axenova, V. G. Zgoda, A. E. Medvedev, Biochemistry Supplemental Series B: Biomedical Chemistry, 2012
Renalase is a recently discovered secretory protein, which is suggested to play a role (which still remains elusive) in regulation of blood pressure. Earlier it was purified from urine of healthy volunteers by means of ammonium sulfate fractionation and subsequent affinity chromatography (Xu ...
Effect of exogenous antioxidants on erythrocyte redox status and hepcidin content in disorders of iron metabolism regulation
14-11-2012 | S. P. Scherbinina, A. A. Levina, I. L. Lisovskaya, F. I. Ataullakhanov, Biochemistry Supplemental Series B: Biomedical Chemistry, 2012
In many diseases associated with impairments in iron metabolism, erythrocytes exhibit an increased sensitivity to oxidative stress induced in vitro. In this study we have examined the antioxidant status of erythrocytes from healthy donors and from 12 patients with disorders of iron ...
Binase penetration into alveolar epithelial cells does not induce cell death
14-11-2012 | H. A. Cabrera-Fuentes, N. V. Kalacheva, R. T. Mukhametshina, P. V. Zelenikhin, A. I. Kolpakov, G. Barreto, K. T. Pre ..., Biochemistry Supplemental Series B: Biomedical Chemistry, 2012
Microbial ribonucleases possess a broad spectrum of biological activities, which demonstrate stimulating properties at low concentrations and cytotoxicity and genotoxicity at high concentrations. Mechanisms of their penetration into the cells still remain unclear. In this study penetration of ...
Hypoxic preconditioning modifies activity of pro- and antioxidant systems in the rat hippocampus
14-11-2012 | M. S. Kislin, S. A. Stroev, T. S. Gluschenko, E. I. Tyulkova, M. Pelto-Huikko, M. O. Samoilov, Biochemistry Supplemental Series B: Biomedical Chemistry, 2012
The effects of repetitive mild hypobaric hypoxic preconditioning on pro- and antioxidant systems in rat hippocampus have been studied. It was found that three-trial preconditioning by mild hypobaric hypoxia (360 mm Hg, 2 h) induced moderate oxidative stress immediately after the last ...
Apoptosis-reactivating agents for targeted anticancer therapy
14-11-2012 | A. A. Philchenkov, Biochemistry Supplemental Series B: Biomedical Chemistry, 2012
The review considers the current knowledge on molecular mechanisms of apoptosis. Particular emphasis is given to the key elements of the extrinsic death receptor pathway and the intrinsic mitochondrial pathway. Dysregulation of apoptotic pathways is considered as a key factor in the survival ...
Soluble guanylate cyclase in molecular mechanisms underlying the therapeutic action of drugs
14-11-2012 | N. V. Pyatakova, I. S. Severina, Biochemistry Supplemental Series B: Biomedical Chemistry, 2012
The influence of ambroxol (a mucolytic agent) on the activity of human platelet soluble guanylate cyclase and rat lung soluble guanylate cyclase and activation of both enzymes by NO-donors (sodium nitroprusside (SNP) and Sin-1) were investigated. Ambroxol in the range of concentrations from ...
Arginine and lysine as products of basic carboxypeptidase activity associated with fibrinolysis
04-09-2012 | A. A. Zhloba, T. F. Subbotina, D. S. Lupan, V. A. Bogova, O. A. Kusheleva, Biochemistry Supplemental Series B: Biomedical Chemistry, 2012
Blood carboxypeptidases play an important role in the regulation of fibrinolysis. We have proposed here the method for the assay of blood carboxypeptidase activity associated with coagulation/fibrinolysis using the natural substrate fibrin and the detection of basic amino acids arginine and ...
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