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198 Newest Publications in biochemistry supplemental series b: biomedical chemistry
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Metabolic fingerprinting of blood plasma from patients with prostate cancer
24-03-2010 | P. G. Lokhov, M. I. Dashtiev, L. V. Bondartsov, A. V. Lisitsa, S. A. Moshkovskii, A. I. Archakov, Biochemistry Supplemental Series B: Biomedical Chemistry, 2010
Application of blood plasma metabolites fingerprinting for the diagnostic of the 2nd stage of prostate cancer has been investigated. The diagnostic sensitivity (95%), specificity (96.7%) and accuracy (95.7%) of the metabolic fingerprinting were much higher then those for the ELISA PSA test ...
Alexander Ivanovich Archakov
24-03-2010 | Biochemistry Supplemental Series B: Biomedical Chemistry, 2010
Alexander Ivanovich Archakov Content Type Journal Article DOI 10.1134/S1990750810010014 Journal Biochemistry (Moscow) Supplemental Series B: Biomedical Chemistry Online ISSN 1990-7516 Print ISSN 1990-7508 Journal Volume Volume 4 Journal Issue Volume 4, Number ...
Nanobiotechnologies in medicine: Nanodiagnostics and nanodrugs
24-03-2010 | A. I. Archakov, Biochemistry Supplemental Series B: Biomedical Chemistry, 2010
Nanobiotechnologies in medicine: Nanodiagnostics and nanodrugs Content Type Journal Article DOI 10.1134/S1990750810010026 Authors A. I. Archakov, Russian Academy of Medical Sciences Institute of Biomedical Chemistry ul. Pogodinslkya 10 Moscow 119121 Russia Journal ...
Zebrafish as a model system for biomedical studies
18-11-2009 | N. F. Belyaeva, V. N. Kashirtseva, N. V. Medvedeva, Yu. Yu. Khudoklinova, O. M. Ipatova, A. I. Archakov, Biochemistry Supplemental Series B: Biomedical Chemistry, 2009
Zebrafish (Danio rerio) is now firmly recognized as a powerful research model for many areas of biology and medicine. Here, we review some achievements of zebrafish-based assays for modeling human diseases and for drug discovery and development. For drug discovery, zebrafish is especially ...
Prediction of functionally related proteins by comparative genomics in silico
18-11-2009 | M. A. Pyatnitskiy, A. V. Lisitsa, A. I. Archakov, Biochemistry Supplemental Series B: Biomedical Chemistry, 2009
The review considers the computational prediction of functionally related proteins by comparative genomics. Growing possibilities of biotechnology for genome sequencing lead to generation of sequences for millions of genes. However, functions of majority of these genes remain unknown, and can ...
Mass spectrometry identification of cytochrome P450 2B4 interaction sites for NADPH: Cytochrome P450 reductase
18-11-2009 | A. V. Ivanov, A. T. Kopylov, V. G. Zgoda, I. Yu. Toropygin, E. V. Khryapova, Yu. D. Ivanov, Biochemistry Supplemental Series B: Biomedical Chemistry, 2009
The interaction sites for protein partners, cytochrome P450 2B4 (d-2B4) and NADPH: cytochrome P450 reductase (d-Fp), have been identified. These proteins form complexes during their functioning. Nonspecific covalent cross-linking of the d-2B4 complexes with d-Fp in the Emulgen 913 monomerized ...
Non-enzymatic glycation of proteins: From diabetes to cancer
18-11-2009 | N. A. Ansari, Z. Rasheed, Biochemistry Supplemental Series B: Biomedical Chemistry, 2009
Incubation of proteins with glucose leads to their non-enzymatic glycation and formation of Amadori products known as an early glycation product. Oxidative cleavage of Amadori products is considered as a major route to advanced glycation endproducts (AGEs) formation in vivo. Non-enzymatic ...
Low-molecular regulators of polypeptide hormone receptors containing LGR-repeats
18-11-2009 | A. O. Shpakov, E. A. Shpakova, Biochemistry Supplemental Series B: Biomedical Chemistry, 2009
During the last years the low-molecular non-peptidic regulators of the polypeptide hormone receptors containing LGR-repeats (LGR-receptors) were identified. The review summarizes and systematizes data on structure and molecular mechanisms realizing the effects of such regulators as agonists ...
Cathepsin K and matrix metalloprotease activities in bone tissue of the OXYS rats during the development of osteoporosis
18-11-2009 | A. A. Venediktova, O. V. Falameeva, N. G. Kolosova, M. A. Sadovoj, T. A. Korolenko, Biochemistry Supplemental Series B: Biomedical Chemistry, 2009
The activity of osteoclast-specific cysteine protease, cathepsin K, and matrix metalloproteases (MMPs) has been investigated in bone tissue of senescence-accelerated OXYS rats and in Wistar rats. At the age of 3 month (the period preceding manifestation of osteoporosis in OXYS rats) cathepsin ...
The effect of complexes of precursors and modulators of coenzyme Q biosynthesis on the functional state of heart mitochondria of old rats
18-11-2009 | E. B. Kuchmenko, D. N. Petukhov, G. V. Donchenko, L. S. Mkhitaryan, S. V. Tymoshchuk, N. A. Strutynskaya, G. L. Vavi ..., Biochemistry Supplemental Series B: Biomedical Chemistry, 2009
Aging is accompanied by changes in activity of electron-transport enzyme complexes in myocardial mitochondria of old rats and by increased sensitivity of the mitochondrial permeability transition pore (MPTP) to inductors of its opening (Ca2+ and phenylarsine oxide). We also observed ...
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