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2,905 Newest Publications in biochemistry
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Botulinum Neurotoxin G Binds Synaptotagmin-II in a Mode Similar to That of Serotype B: Tyrosine 1186 and Lysine 1191 Cause Its Lower Affinity
17-05-2013 | Gesche Willjes; Stefan Mahrhold; Jasmin Strotmeier; Timo Eichner; Andreas Rummel; Thomas Binz, Biochemistry, 2013
Botulinum neurotoxins (BoNTs) block neurotransmitter release by proteolyzing SNARE proteins in peripheral nerve terminals. Entry into neurons occurs subsequent to interaction with gangliosides and a synaptic vesicle protein. Isoforms I and II of synaptotagmin were shown to act as protein ...
Complex Structures between the N-Type Calcium Channel (CaV2.2) and ω-Conotoxin GVIA Predicted via Molecular Dynamics
17-05-2013 | Rong Chen; Shin-Ho Chung, Biochemistry, 2013
The N-type voltage-gated Ca2+ channel CaV2.2 is one of the important targets for pain management. ω-Conotoxins isolated from venoms of cone snails, which specifically inhibit CaV2.2, are promising scaffolds for novel analgesics. The inhibitory action of ω-conotoxins on CaV2.2 has been ...
Peptide-Targeted Delivery of a pH Sensor for Quantitative Measurements of Intraglycosomal pH in Live Trypanosoma brucei
17-05-2013 | Sheng Lin; Meredith T. Morris; P. Christine Ackroyd; James C. Morris; Kenneth A. Christensen, Biochemistry, 2013
Studies of dynamic changes in organelles of protozoan parasite Trypanosoma brucei have been limited, in part because of the difficulty of targeting analytical probes to specific subcellular compartments. Here we demonstrate application of a ratiometric probe for pH quantification in T. brucei ...
Electron Transfer Reactions of Candidate Tumor Suppressor 101F6 Protein, a Cytochrome b561 Homologue, with Ascorbate and Monodehydroascorbate Radical
16-05-2013 | Mariam C. Recuenco; Md. Motiur Rahman; Fusako Takeuchi; Kazuo Kobayashi; Motonari Tsubaki, Biochemistry, 2013
The candidate tumor suppressor 101F6 protein is a homologue of adrenal chromaffin granule cytochrome b561, which is involved in the electron transfer from cytosolic ascorbate to intravesicular monodehydroascorbate radical. Since the tumor suppressor activity of 101F6 was enhanced in the ...
The αA66–80 Peptide Interacts with Soluble α-Crystallin and Induces Its Aggregation and Precipitation: A Contribution to Age-Related Cataract Formation
16-05-2013 | Rama Kannan; Puttur Santhoshkumar; Brian P. Mooney; K. Krishna Sharma, Biochemistry, 2013
Formation of protein aggregates in the aging eye lens has been shown to correlate with progressive accumulation of specific low-molecular weight (LMW) peptides derived from crystallins. Prominent among the LMW fragments is αA66–80, a peptide derived from αA-crystallin and present at higher ...
Redirecting P450 EryK Specificity by Rational Site-Directed Mutagenesis
16-05-2013 | Linda Celeste Montemiglio; Alberto Macone; Chiara Ardiccioni; Giovanna Avella; Beatrice Vallone; Carmelinda Savino, Biochemistry, 2013
The C-12 hydroxylase EryK is a bacterial cytochrome P450, active during one of the final tailoring steps of erythromycin A (ErA) biosynthesis. Its tight substrate specificity, restricted to the metabolic intermediate ErD, leads to the accumulation in the culture broth of a shunt metabolite, ...
Covalent Inhibition of Serine β-Lactamases by Novel Hydroxamic Acid Derivatives
16-05-2013 | Ronak Tilvawala; R. F. Pratt, Biochemistry, 2013
The effectiveness of β-lactam antibiotics is greatly limited by the ability of bacteria to produce β-lactamases. These enzymes catalyze the hydrolysis of β-lactams and thus loss of their antibiotic activity. The search for inhibitors of β-lactamases began soon after β-lactams were introduced ...
Design, Synthesis, and Characterization of Heparin-Binding Peptoids
15-05-2013 | Bruce Kevin Ford; Mark Hamza; Dallas L. Rabenstein, Biochemistry, 2013
A series of N-substituted glycine oligomers (peptoids) of varying length and side chains was synthesized with the aim of producing peptidomimetics that would bind with high affinity to heparin and thereby neutralize its anticoagulant activity. To this end, a library of 29 peptoids was ...
Modified Reactivity toward O2 in First Shell Variants of Fet3p: Geometric and Electronic Structure Requirements for a Functioning Trinuclear Copper Cluster
15-05-2013 | Christian H. Kjaergaard; Munzarin F. Qayyum; Anthony J. Augustine; Lynn Ziegler; Daniel J. Kosman; Keith O. Hodgson; ..., Biochemistry, 2013
Multicopper oxidases (MCOs) carry out the most energy efficient reduction of O2 to H2O known, i.e., with the lowest overpotential. This four-electron process requires an electron mediating type 1 (T1) Cu site and an oxygen reducing trinuclear Cu cluster (TNC), consisting of a binuclear type 3 ...
Different Molecular Mechanisms of Inhibition of Bovine Viral Diarrhea Virus and Hepatitis C Virus RNA-Dependent RNA Polymerases by a Novel Benzimidazole
15-05-2013 | Shailendra Asthana; Saumya Shukla; Attilio V. Vargiu; Matteo Ceccarelli; Paolo Ruggerone; Giuseppe Paglietti; Maria ..., Biochemistry, 2013
The virus-encoded RNA-dependent RNA polymerase (RdRp) has emerged as a primary target in the search for selective inhibitors of Flaviviridae. Recently, we reported on the selective inhibition, in cell-based assays, of both BVDV (EC50 = 0.80 ± 0.06 μM) and HCV (EC50 = 1.11 ± 0.15 μM) by ...
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