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2,905 Newest Publications in biochemistry
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Residue-Specific Fluorescent Probes of α-Synuclein: Detection of Early Events at the N- and C-Termini during Fibril Assembly
21-02-2011 | Thai Leong Yap; Candace M. Pfefferkorn; Jennifer C. Lee, Biochemistry, 2011
In the Parkinson’s disease-associated state, α-synuclein undergoes large conformational changes, forming ordered, β-sheet-containing fibrils. To unravel the role of specific residues during the fibril assembly process, we prepared single-Cys mutants in the disordered (G7C and Y136C) and ...
Mutations That Probe the Cooperative Assembly of O6-Alkylguanine-DNA Alkyltransferase Complexes
21-02-2011 | Claire A. Adams; Michael G. Fried, Biochemistry, 2011
O6-Alkylguanine-DNA alkyltransferase (AGT) repairs mutagenic O6-alkylguanine and O4-alkylthymine adducts present in DNA that has been exposed to alkylating agents. AGT binds DNA cooperatively, and models of cooperative complexes predict that residues 1−7 of one protein molecule and residues ...
Natural Osmolytes Remodel the Aggregation Pathway of Mutant Huntingtin Exon 1
20-02-2011 | Tejas Borwankar; Christoph Röthlein; Gong Zhang; Anne Techen; Carsten Dosche; Zoya Ignatova, Biochemistry, 2011
In response to stress small organic compounds termed osmolytes are ubiquitously accumulated in all cell types to regulate the intracellular solvent quality and to counteract the deleterious effect on the stability and function of cellular proteins. Given the evidence that destabilization of ...
Enhanced Binding of Apolipoprotein A-I Variants Associated with Hypertriglyceridemia to Triglyceride-Rich Particles
20-02-2011 | Irina N. Gorshkova; David Atkinson, Biochemistry, 2011
Hypertriglyceridemia (HTG) is a common lipid abnormality in humans. However, its etiology remains largely unknown. It was shown that severe HTG can be induced in mice by overexpression of wild-type (WT) apolipoprotein E (apoE) or specific apoA-I mutants. Certain mutations in apoE4 were found ...
Uptake, Distribution, and Speciation of Selenoamino Acids by Human Cancer Cells: X-ray Absorption and Fluorescence Methods
20-02-2011 | Claire M. Weekley; Jade B. Aitken; Stefan Vogt; Lydia A. Finney; David J. Paterson; Martin D. de Jonge; Daryl L. How ..., Biochemistry, 2011
Selenium compounds exhibit chemopreventative properties at supranutritional doses, but the efficacy of selenium supplementation in cancer prevention is dependent on the chemical speciation of the selenium supplement and its metabolites. The uptake, speciation, and distribution of the common ...
Robust Self-Association Is a Common Feature of Mammalian Visual Arrestin-1
18-02-2011 | Miyeon Kim; Susan M. Hanson; Sergey A. Vishnivetskiy; Xiufeng Song; Whitney M. Cleghorn; Wayne L. Hubbell; Vsevolod ..., Biochemistry, 2011
Arrestin-1 binds light-activated phosphorhodopsin and ensures rapid signal termination. Its deficiency in humans and mice results in prolonged signaling and rod degeneration. However, most of the biochemical studies were performed on bovine arrestin-1, which was shown to self-associate ...
Polymorphism of the Epidermal Growth Factor Receptor Extracellular Ligand Binding Domain: The Dimer Interface Depends on Domain Stabilization
18-02-2011 | Zhiyong Zhang; Willy Wriggers, Biochemistry, 2011
Epidermal growth factor receptors (EGFRs) and their cytoplasmic tyrosine kinases play important roles in cell proliferation and signaling. The EGFR extracellular domain (sEGFR) forms a dimer upon the binding of ligands, such as epidermal growth factor (EGF) and transforming growth factor α ...
Phosphorylation of Annexin A1 by TRPM7 Kinase: A Switch Regulating the Induction of an α-Helix
18-02-2011 | Maxim V. Dorovkov; Alla S. Kostyukova; Alexey G. Ryazanov, Biochemistry, 2011
TRPM7 is an unusual bifunctional protein consisting of an α-kinase domain fused to a TRP ion channel. Previously, we have identified annexin A1 as a substrate for TRPM7 kinase and found that TRPM7 phosphorylates annexin A1 at Ser5 within the N-terminal α-helix. Annexin A1 is a Ca2+-dependent ...
Lyme Disease Enolpyruvyl-UDP-GlcNAc Synthase: Fosfomycin-Resistant MurA from Borrelia burgdorferi, a Fosfomycin-Sensitive Mutant, and the Catalytic Role of the Active Site Asp
18-02-2011 | Shan Jiang; Meghann E. Gilpin; Menat Attia; Yi-Lee Ting; Paul J. Berti; Shan Jiang; Meghann E. Gilpin; Menat Attia, Biochemistry, 2011
MurAs (enolpyruvyl-UDP-GlcNAc synthases) from pathogenic bacteria such as Borrelia burgdorferi (Lyme disease) and tuberculosis are fosfomycin resistant because an Asp-for-Cys substitution prevents them from being alkylated by this epoxide antibiotic. Previous attempts to characterize ...
Substrate Specificity of Protein Tyrosine Phosphatases 1B, RPTPα, SHP-1, and SHP-2
18-02-2011 | Lige Ren; Xianwen Chen; Rinrada Luechapanichkul; Nicholas G. Selner; Tiffany M. Meyer; Anne-Sophie Wavreille; Richar ..., Biochemistry, 2011
We determined the substrate specificities of the protein tyrosine phosphatases (PTPs) PTP1B, RPTPα, SHP-1, and SHP-2 by on-bead screening of combinatorial peptide libraries and solution-phase kinetic analysis of individually synthesized phosphotyrosyl (pY) peptides. These PTPs exhibit ...
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