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372 Newest Publications in cell biochemistry and biophysics

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Mechanism of Two Novel Human GJC3 Missense Mutations in Causing Non-Syndromic Hearing Loss

26-11-2012 | Ching-Chyuan Su, Shuan-Yow Li, Yung-Chang Yen, Jhih-Hao Nian, Wei-Guang Liang, Jiann-Jou Yang, Cell Biochemistry and Biophysics, 2012

Connexins (CXs), as a component of gap junction channel, are homologous four transmembrane-domain proteins, with numerous studies confirming their auditory functions. Among a cohort of patients having incurred non-syndromic hearing loss, we identified two novel missense mutations, p.R15G and ...

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Complete Radio Frequency Ablation of Hepatocellular Carcinoma Adjacent to the Main Bile Duct and Blood Vessels Between the First and the Second Hepatic Portal

26-11-2012 | Jiang Kai, Su Ming, Liu Yang, Zhang Wen-zhi, Zhao Xiang-qian, Liu Zhe, Lv Wen-ping, Liu Zhi-wei, Dong Jia-hong, Cell Biochemistry and Biophysics, 2012

In cases where hepatocellular carcinoma cannot be surgically removed either due to the capacity of hepatic functional reserve or the special location of the tumor, a radiofrequency ablation (RFA) is recognized to be an effective and minimally invasive treatment. However, when the tumor is ...

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Non-native States of Bovine Beta-Lactoglobulin Induced by Acetonitrile: pH-Dependent Unfolding of the Two Genetic Variants A and B

19-11-2012 | Zainab Naqvi, Ejaz Ahmad, Rizwan Hasan Khan, Mohammed Saleemuddin, Cell Biochemistry and Biophysics, 2012

Acetonitrile (ACN)-induced unfolding of the beta-lactoglobulin variants A and B was investigated at pH 2.0, 7.0 and 9.0. ACN caused α-helix induction at low concentrations but lead to major conformational alterations when the concentration was raised. ACN also induced a ...

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High Levels of Glucose Induced the Caspase-3/PARP Signaling Pathway, Leading to Apoptosis in Human Periodontal Ligament Fibroblasts

19-11-2012 | Jiaqiang Liu, Yong Wu, Bo Wang, Xiao Yuan, Bing Fang, Cell Biochemistry and Biophysics, 2012

Periodontitis is one of the main complications of diabetes mellitus, and much research has been conducted on their relationship. However, the mechanism by which high glucose levels induce damage of periodontal ligament fibroblasts is still unclear. In this study, we investigated the effects ...

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A New Insight into Structural and Functional Impact of Single-Nucleotide Polymorphisms in PTEN Gene

19-11-2012 | C. George Priya Doss, B. Rajith, Cell Biochemistry and Biophysics, 2012

Phosphatase and tensin homolog (PTEN) plays essential roles in cellular processes including survival, proliferation, energy metabolism, and cellular architecture. Activating the mutations of PTEN has long been known to produce a variety of disorders, mainly diabetes and cancer in humans. ...

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Gossypol Interferes with Both Type I and Type II Topoisomerase Activities Without Generating Strand Breaks

19-11-2012 | Muge Senarisoy, Pakize Canturk, Sevil Zencir, Yusuf Baran, Zeki Topcu, Cell Biochemistry and Biophysics, 2012

A considerable number of agents with chemotherapeutic potentials reported over the past years were shown to interfere with the reactions of DNA topoisomerases, the essential enzymes that regulate conformational changes in DNA topology. Gossypol, a naturally occurring bioactive phytochemical ...

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Differential Effects of G- and F-Actin on the Plasma Membrane Calcium Pump Activity

14-11-2012 | Laura Vanagas, María Candelaria de La Fuente, Marianela Dalghi, Mariela Ferreira-Gomes, Rolando C. Rossi, Emanuel E. ..., Cell Biochemistry and Biophysics, 2012

We have previously shown that plasma membrane calcium ATPase (PMCA) pump activity is affected by the membrane protein concentration (Vanagas et al., Biochim Biophys Acta 1768:1641–1644, 2007). The results of this study provided evidence for the involvement of the actin cytoskeleton. In this ...

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Modulation of Chitotriosidase During Macrophage Differentiation

14-11-2012 | Michelino Di Rosa, Giulia Malaguarnera, Corinne De Gregorio, Fabio D’Amico, Maria Clorinda Mazzarino, Lucia Malaguarnera, Cell Biochemistry and Biophysics, 2012

Macrophages as a principal component of immune system play an important role in the initiation, modulation, and final activation of the immune response against pathogens. Upon stimulation with different cytokines, macrophages can undergo classical or alternative activation to become M1 or M2 ...

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Angiostatic Properties of Sulindac and Celecoxib in the Experimentally Induced Inflammatory Colorectal Cancer

13-11-2012 | Vivek Vaish, Honit Piplani, Chandan Rana, Sankar Nath Sanyal, Cell Biochemistry and Biophysics, 2012

Initiation of various cancers has been observed to be regulated via a prolonged inflammatory state in the tissues. However, molecular role of such a localized inflammation is not clear in the advanced stages of colorectal cancer. In this study, we have elaborated the role of various pro- and ...

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Suppression of 12-O-Tetradecanoylphorbol-13-Acetate-Induced MCF-7 Breast Adenocarcinoma Cells Invasion/Migration by α-Tomatine Through Activating PKCα/ERK/NF-κB-Dependent MMP-2/MMP-9 Expressions

31-10-2012 | Min-Der Shi, Yuan-Wei Shih, Ya-Shan Lee, Yueh-Feng Cheng, Li-Yu Tsai, Cell Biochemistry and Biophysics, 2012

α-Tomatine, isolated from Lycopersicon esculentum Linn., is a naturally occurring glycoalkaloids in immature green tomatoes. Some reports demonstrated that α-tomatine had various anti-carcinogenic properties. First, the result demonstrated α-tomatine could inhibit TPA-induced the abilities of ...

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