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279 Newest Publications in organic letters

matching the following criteria

Asymmetric Total Syntheses of Megacerotonic Acid and Shimobashiric Acid A

20-Feb-2015 | Scott W. Krabbe; Jeffrey S. Johnson, Organic Letters, 2015

The asymmetric total syntheses of the α-benzylidene-γ-butyrolactone natural products megacerotonic acid and shimobashiric acid A have been accomplished in nine and 11 steps, respectively, from simple, commercially available starting materials. The key step for each synthesis is the ...


A Novel and Selective Fluoride Opening of Aziridines by XtalFluor-E. Synthesis of Fluorinated Diamino Acid Derivatives

16-Feb-2015 | Melinda Nonn; Loránd Kiss; Matti Haukka; Santos Fustero; Ferenc Fülöp, Organic Letters, 2015

The selective introduction of fluorine onto the skeleton of an aminocyclopentane or cyclohexane carboxylate has been developed through a novel and efficient fluoride opening of an activated aziridine ring with XtalFluor-E. The reaction proceeded through a stereoselective aziridination of the ...


Simple Aza-Conjugate Addition Methodology for the Synthesis of Isoindole Nitrones and 3,4-Dihydroisoquinoline Nitrones

11-Feb-2015 | Lucy R. Peacock; Robert S. L. Chapman; Adam C. Sedgwick; Mary F. Mahon; Dominique Amans; Steven D. Bull, Organic Letters, 2015

Aryl-aldehydes containing ortho-substituted α,β-unsaturated carboxylic acid derivatives react with hydroxylamine to afford reactive N-hydroxy-carbinolamine intermediates that undergo intramolecular aza-conjugate addition reactions to afford isoindole nitrones and 3,4-dihydroisoquinoline nitrones ...


Lewis and Brønsted Acid Induced (3 + 2)-Annulation of Donor–Acceptor Cyclopropanes to Alkynes: Indene Assembly

10-Feb-2015 | Eduard R. Rakhmankulov; Konstantin L. Ivanov; Ekaterina M. Budynina; Olga A. Ivanova; Alexey O. Chagarovskiy; Dmitri ..., Organic Letters, 2015

Organic Letters DOI: 10.1021/ol5037562


Selective Lewis Acid Catalyzed Assembly of Phosphonomethyl Ethers: Three-Step Synthesis of Tenofovir

09-Feb-2015 | Charles E. Ocampo; Doris Lee; Timothy F. Jamison, Organic Letters, 2015

Organic Letters DOI: 10.1021/ol503612h


Total Synthesis and Biological Evaluation of the Tetramic Acid Based Natural Product Harzianic Acid and Its Stereoisomers

28-Jan-2015 | Alan R. Healy; Francesco Vinale; Matteo Lorito; Nicholas J. Westwood, Organic Letters, 2015

The bioactive natural product harzianic acid was prepared for the first time in just six steps (longest linear sequence) with an overall yield of 22%. The identification of conditions to telescope amide bond formation and a Lacey–Dieckmann reaction into one pot proved important. The three ...


Discovery of a New Family of Dieckmann Cyclases Essential to Tetramic Acid and Pyridone-Based Natural Products Biosynthesis

26-Jan-2015 | Chun Gui; Qinglian Li; Xuhua Mo; Xiangjing Qin; Junying Ma; Jianhua Ju, Organic Letters, 2015

Bioinformatic analyses indicate that TrdC, SlgL, LipX2, KirHI, and FacHI belong to a group of highly homologous proteins involved in biosynthesis of actinomycete-derived tirandamycin B, streptolydigin, α-lipomycin, kirromycin, and factumycin, respectively. However, assignment of their ...


Transition-Metal-Free Synthesis of Phenanthridinones from Biaryl-2-oxamic Acid under Radical Conditions

08-Jan-2015 | Ming Yuan; Li Chen; Junwei Wang; Shenjie Chen; Kongchao Wang; Yongbo Xue; Guangmin Yao; Zengwei Luo; Yonghui Zhang, Organic Letters, 2015

Organic Letters DOI: 10.1021/ol503459s


Straightforward Synthesis of Novel Enantiopure α-Trifluoromethylated Azetidine 2-Carboxylic Acid and Homoserines

06-Jan-2015 | Nathalie Lensen; Joyce Marais; Thierry Brigaud, Organic Letters, 2015

Organic Letters DOI: 10.1021/ol503448w


Correction to p-Toluenesulfonic Acid Mediated 1,3-Dipolar Cycloaddition of Nitroolefins with NaN3 for Synthesis of 4-Aryl-NH-1,2,3-triazoles

31-Dec-2014 | Xue-Jing Quan; Zhi-Hui Ren; Yao-Yu Wang; Zheng-Hui Guan, Organic Letters, 2014

Organic Letters DOI: 10.1021/ol503621y


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