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282 Newest Publications in organic letters

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Chojalactones A–C, Cytotoxic Butanolides Isolated from Streptomyces sp. Cultivated with Mycolic Acid Containing Bacterium

05-Mar-2015 | Shotaro Hoshino; Toshiyuki Wakimoto; Hiroyasu Onaka; Ikuro Abe, Organic Letters, 2015

The soil-derived bacterium, Streptomyces sp. CJ-5, was cocultured with the mycolic acid-containing bacterium Tsukamurella pulmonis TP-B0596. The combined culture method significantly enhanced the production of the secondary metabolites in Streptomyces sp. CJ-5, leading to the isolation of three ...

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Regioselective Synthesis of Substituted Arenes via Aerobic Oxidative [3 + 3] Benzannulation Reactions of α,β-Unsaturated Aldehydes and Ketones

27-Feb-2015 | Prabhakar Ramchandra Joshi; Sridhar Undeela; Doni Dhanoj Reddy; Kiran Kumar Singarapu; Rajeev S. Menon, Organic Letters, 2015

Facile conversion of α,β-unsaturated aldehydes and ketones into highly substituted arenes via a base-mediated, completely regioselective, air-oxidative [3 + 3] benzannulation reaction with readily available 4-sulfonylcrotonates or 1,3-bisphenylsulfonylpropene is reported. The reaction can also be ...

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Additive-Free Decarboxylative Coupling of Cinnamic Acid Derivatives in Water: Synthesis of Allyl Amines

23-Feb-2015 | Kyungho Park; Sunwoo Lee, Organic Letters, 2015

Organic Letters DOI: 10.1021/acs.orglett.5b00303

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Asymmetric Total Syntheses of Megacerotonic Acid and Shimobashiric Acid A

20-Feb-2015 | Scott W. Krabbe; Jeffrey S. Johnson, Organic Letters, 2015

The asymmetric total syntheses of the α-benzylidene-γ-butyrolactone natural products megacerotonic acid and shimobashiric acid A have been accomplished in nine and 11 steps, respectively, from simple, commercially available starting materials. The key step for each synthesis is the ...

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A Novel and Selective Fluoride Opening of Aziridines by XtalFluor-E. Synthesis of Fluorinated Diamino Acid Derivatives

16-Feb-2015 | Melinda Nonn; Loránd Kiss; Matti Haukka; Santos Fustero; Ferenc Fülöp, Organic Letters, 2015

The selective introduction of fluorine onto the skeleton of an aminocyclopentane or cyclohexane carboxylate has been developed through a novel and efficient fluoride opening of an activated aziridine ring with XtalFluor-E. The reaction proceeded through a stereoselective aziridination of the ...

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Simple Aza-Conjugate Addition Methodology for the Synthesis of Isoindole Nitrones and 3,4-Dihydroisoquinoline Nitrones

11-Feb-2015 | Lucy R. Peacock; Robert S. L. Chapman; Adam C. Sedgwick; Mary F. Mahon; Dominique Amans; Steven D. Bull, Organic Letters, 2015

Aryl-aldehydes containing ortho-substituted α,β-unsaturated carboxylic acid derivatives react with hydroxylamine to afford reactive N-hydroxy-carbinolamine intermediates that undergo intramolecular aza-conjugate addition reactions to afford isoindole nitrones and 3,4-dihydroisoquinoline nitrones ...

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Lewis and Brønsted Acid Induced (3 + 2)-Annulation of Donor–Acceptor Cyclopropanes to Alkynes: Indene Assembly

10-Feb-2015 | Eduard R. Rakhmankulov; Konstantin L. Ivanov; Ekaterina M. Budynina; Olga A. Ivanova; Alexey O. Chagarovskiy; Dmitri ..., Organic Letters, 2015

Organic Letters DOI: 10.1021/ol5037562

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Selective Lewis Acid Catalyzed Assembly of Phosphonomethyl Ethers: Three-Step Synthesis of Tenofovir

09-Feb-2015 | Charles E. Ocampo; Doris Lee; Timothy F. Jamison, Organic Letters, 2015

Organic Letters DOI: 10.1021/ol503612h

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Total Synthesis and Biological Evaluation of the Tetramic Acid Based Natural Product Harzianic Acid and Its Stereoisomers

28-Jan-2015 | Alan R. Healy; Francesco Vinale; Matteo Lorito; Nicholas J. Westwood, Organic Letters, 2015

The bioactive natural product harzianic acid was prepared for the first time in just six steps (longest linear sequence) with an overall yield of 22%. The identification of conditions to telescope amide bond formation and a Lacey–Dieckmann reaction into one pot proved important. The three ...

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Discovery of a New Family of Dieckmann Cyclases Essential to Tetramic Acid and Pyridone-Based Natural Products Biosynthesis

26-Jan-2015 | Chun Gui; Qinglian Li; Xuhua Mo; Xiangjing Qin; Junying Ma; Jianhua Ju, Organic Letters, 2015

Bioinformatic analyses indicate that TrdC, SlgL, LipX2, KirHI, and FacHI belong to a group of highly homologous proteins involved in biosynthesis of actinomycete-derived tirandamycin B, streptolydigin, α-lipomycin, kirromycin, and factumycin, respectively. However, assignment of their ...

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