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1,917 Newest Publications in plos one
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Xuezhikang, Extract of Red Yeast Rice, Improved Abnormal Hemorheology, Suppressed Caveolin-1 and Increased eNOS Expression in Atherosclerotic Rats
10-05-2013 | Xin-Yuan Zhu et al., PLoS ONE, 2013
by Xin-Yuan Zhu, Pei Li, Ya-Bing Yang, Mei-Lin Liu Background Xuezhikang is the extract of red yeast rice, which has been widely used for the management of atherosclerotic disease, but the molecular basis of its antiatherosclerotic effects has not yet been fully identified. Here we ...
Notch Signaling Maintains Neural Rosette Polarity
10-05-2013 | Heather Main et al., PLoS ONE, 2013
by Heather Main, Jelena Radenkovic, Shao-bo Jin, Urban Lendahl, Emma R. Andersson Formation of the metazoan body plan requires a complex interplay of morphological changes and patterning, and central to these processes is the establishment of apical/basal cell polarity. In the developing ...
Ventral Hippocampal Kappa Opioid Receptors Mediate the Renewal of Fear following Extinction in the Rat
10-05-2013 | Sindy Cole et al., PLoS ONE, 2013
by Sindy Cole, Rick Richardson, Gavan P. McNally The hippocampus is part of a neural network which regulates the renewal of fear following extinction. Both the ventral (VH) and dorsal (DH) hippocampus have been shown to be necessary for renewal, however the critical receptors and ...
Construction of New Ligation-Independent Cloning Vectors for the Expression and Purification of Recombinant Proteins in Silkworms Using BmNPV Bacmid System
10-05-2013 | Tatsuya Kato et al., PLoS ONE, 2013
by Tatsuya Kato, James R. Thompson, Enoch Y. Park A ligation independent cloning (LIC) system has been developed to facilitate the rapid and high-efficiency cloning of genes in a Bombyx mori expression system. This system was confirmed by the expression of human microsomal triglyceride ...
Downregulation of OPA3 Is Responsible for Transforming Growth Factor-β-Induced Mitochondrial Elongation and F-Actin Rearrangement in Retinal Pigment Epithelial ARPE-19 Cells
03-05-2013 | Seung-Wook Ryu et al., PLoS ONE, 2013
by Seung-Wook Ryu, Jonghee Yoon, Nambin Yim, Kyungsun Choi, Chulhee Choi Transforming growth factor-β signaling is known to be a key signaling pathway in the induction of epithelial–mesenchymal transition. However, the mechanism of TGF-β signaling in the modulation of EMT remains unclear. ...
Secretome Analysis Defines the Major Role of SecDF in Staphylococcus aureus Virulence
03-05-2013 | Chantal Quiblier et al., PLoS ONE, 2013
by Chantal Quiblier, Kati Seidl, Bernd Roschitzki, Annelies S. Zinkernagel, Brigitte Berger-Bächi, Maria M. Senn The Sec pathway plays a prominent role in protein export and membrane insertion, including the secretion of major bacterial virulence determinants. The accessory Sec constituent ...
Regulation of Hedgehog Signaling by Myc-Interacting Zinc Finger Protein 1, Miz1
03-05-2013 | Jiuyi Lu et al., PLoS ONE, 2013
by Jiuyi Lu, Minyong Chen, Xiu-Rong Ren, Jiangbo Wang, H. Kim Lyerly, Larry Barak, Wei Chen Smoothened (Smo) mediated Hedgehog (Hh) signaling plays an essential role in regulating embryonic development and postnatal tissue homeostasis. Aberrant activation of the Hh pathway contributes to ...
Heat Shock Protein 90 Inhibitors Repress Latent Membrane Protein 1 (LMP1) Expression and Proliferation of Epstein-Barr Virus-Positive Natural Killer Cell Lymphoma
03-05-2013 | Takayuki Murata et al., PLoS ONE, 2013
by Takayuki Murata, Seiko Iwata, Mohammed Nure Alam Siddiquey, Tetsuhiro Kanazawa, Fumi Goshima, Daisuke Kawashima, Hiroshi Kimura, Tatsuya Tsurumi Epstein-Barr virus (EBV) LMP1 is a major oncoprotein expressed in latent infection. It functions as a TNFR family member and constitutively ...
Novel Molecular Tumor Cell Markers in Regional Lymph Nodes and Blood Samples from Patients Undergoing Surgery for Non-Small Cell Lung Cancer
03-05-2013 | Oddmund Nordgård et al., PLoS ONE, 2013
by Oddmund Nordgård, Gurpartap Singh, Steinar Solberg, Lars Jørgensen, Ann Rita Halvorsen, Rune Smaaland, Odd Terje Brustugun, Åslaug Helland Introduction Recent evidence suggests that microscopic lymph node metastases and circulating tumor cells may have clinical importance in lung ...
Estrogen-Dependent Dynamic Profile of eNOS-DNA Associations in Prostate Cancer
03-05-2013 | Simona Nanni et al., PLoS ONE, 2013
by Simona Nanni, Aurora Aiello, Agnese Re, Alessandro Guffanti, Valentina Benvenuti, Claudia Colussi, Luis Jaime Castro-Vega, Armando Felsani, Arturo Londono-Vallejo, Maurizio C. Capogrossi, Silvia Bacchetti, Carlo Gaetano, Alfredo Pontecorvi, Antonella Farsetti In previous work we have ...
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