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28,294 Newest Publications in proceedings of the national academy of sciences current issue

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G{alpha}s protein binds ubiquitin to regulate epidermal growth factor receptor endosomal sorting [Cell Biology]

19-Dec-2017 | Xuezhi Li; Danny Létourneau; Brian Holleran; Richard Leduc; Pierre Lavigne; Christine Lavoie, Proceedings of the National Academy of Sciences current issue, 2017

The Gαs subunit is classically involved in the signal transduction of G protein-coupled receptors (GPCRs) at the plasma membrane. Recent evidence has revealed noncanonical roles for Gαs in endosomal sorting of receptors to lysosomes. However, the mechanism of action of Gαs in this sorting step is ...

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Self-healing catalysis in water [Chemistry]

19-Dec-2017 | Cyrille Costentin; Daniel G. Nocera, Proceedings of the National Academy of Sciences current issue, 2017

Principles for designing self-healing water-splitting catalysts are presented together with a formal kinetics model to account for the key chemical steps needed for self-healing. Self-healing may be realized if the catalysts are able to self-assemble at applied potentials less than that needed ...

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Superhydrophobic diving flies (Ephydra hians) and the hypersaline waters of Mono Lake [Chemistry]

19-Dec-2017 | Floris van Breugel; Michael H. Dickinson, Proceedings of the National Academy of Sciences current issue, 2017

The remarkable alkali fly, Ephydra hians, deliberately crawls into the alkaline waters of Mono Lake to feed and lay eggs. These diving flies are protected by an air bubble that forms around their superhydrophobic cuticle upon entering the lake. To study the physical mechanisms underlying this ...

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Epigenetic therapy activates type I interferon signaling in murine ovarian cancer to reduce immunosuppression and tumor burden [Medical Sciences]

19-Dec-2017 | Meredith L. Stone; Katherine B. Chiappinelli; Huili Li; Lauren M. Murphy; Meghan E. Travers; Michael J. Topper; Dimi ..., Proceedings of the National Academy of Sciences current issue, 2017

Ovarian cancer is the most lethal of all gynecological cancers, and there is an urgent unmet need to develop new therapies. Epithelial ovarian cancer (EOC) is characterized by an immune suppressive microenvironment, and response of ovarian cancers to immune therapies has thus far been ...

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Mechanism of ion adsorption to aqueous interfaces: Graphene/water vs. air/water [Chemistry]

19-Dec-2017 | Debra L. McCaffrey; Son C. Nguyen; Stephen J. Cox; Horst Weller; A. Paul Alivisatos; Phillip L. Geissler; Richard J. ..., Proceedings of the National Academy of Sciences current issue, 2017

The adsorption of ions to aqueous interfaces is a phenomenon that profoundly influences vital processes in many areas of science, including biology, atmospheric chemistry, electrical energy storage, and water process engineering. Although classical electrostatics theory predicts that ions are ...

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CD1b-restricted GEM T cell responses are modulated by Mycobacterium tuberculosis mycolic acid meromycolate chains [Immunology and Inflammation]

19-Dec-2017 | Andrew Chancellor; Anna S. Tocheva; Chris Cave-Ayland; Liku Tezera; Andrew White; Juma’a R. Al Dulayymi; John S. Bri ..., Proceedings of the National Academy of Sciences current issue, 2017

Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a major human pandemic. Germline-encoded mycolyl lipid-reactive (GEM) T cells are donor-unrestricted and recognize CD1b-presented mycobacterial mycolates. However, the molecular requirements governing mycolate antigenicity for the ...

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Encoding model of temporal processing in human visual cortex [Psychological and Cognitive Sciences]

19-Dec-2017 | Anthony Stigliani; Brianna Jeska; Kalanit Grill-Spector, Proceedings of the National Academy of Sciences current issue, 2017

How is temporal information processed in human visual cortex? Visual input is relayed to V1 through segregated transient and sustained channels in the retina and lateral geniculate nucleus (LGN). However, there is intense debate as to how sustained and transient temporal channels contribute to ...

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No reason to reconsider HIF-2 as an oncogene in neuroblastoma and other cancer forms [Biological Sciences]

19-Dec-2017 | Sofie Mohlin; Kristoffer von Stedingk; Alexander Pietras; Sven Påhlman, Proceedings of the National Academy of Sciences current issue, 2017

Westerlund et al. (1) conclude that HIF-2α is linked to neuroblastoma suppression, contradicting several previous observations and current views of the role of HIF-2 in tumorigenesis. We believe that their conclusions are based on flawed cellular models and inappropriate interpretations of their ...

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Extending density functional embedding theory for covalently bonded systems [Chemistry]

19-Dec-2017 | Kuang Yu; Emily A. Carter, Proceedings of the National Academy of Sciences current issue, 2017

Quantum embedding theory aims to provide an efficient solution to obtain accurate electronic energies for systems too large for full-scale, high-level quantum calculations. It adopts a hierarchical approach that divides the total system into a small embedded region and a larger environment, using ...

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Correction for Giang et al., Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus [Correction]

19-Dec-2017 | Proceedings of the National Academy of Sciences current issue, 2017

MEDICAL SCIENCES Correction for “Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus,” by Erick Giang, Marcus Dorner, Jannick C. Prentoe, Marlène Dreux, Matthew J. Evans, Jens Bukh, Charles M. Rice, Alexander Ploss, Dennis R. Burton, and Mansun Law, ...

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