My watch list
my.chemeurope.com  
Login  

13,473 Newest Publications in proceedings of the national academy of sciences current issue

rss
matching the following criteria

SHP-2 deletion in postmigratory neural crest cells results in impaired cardiac sympathetic innervation [Developmental Biology]

08-04-2014 | Jacquelyn D. Lajiness; Paige Snider; Jian Wang; Gen-Sheng Feng; Maike Krenz; Simon J. Conway, Proceedings of the National Academy of Sciences current issue, 2014

Autonomic innervation is an essential component of cardiovascular regulation that is first established from the neural crest (NC) lineage in utero and continues developing postnatally. Although in vitro studies have indicated that SH2-containing protein tyrosine phosphatase 2 (SHP-2) is a ...

more

Fish navigation of large dams emerges from their modulation of flow field experience [Environmental Sciences]

08-04-2014 | R. Andrew Goodwin; Marcela Politano; Justin W. Garvin; John M. Nestler; Duncan Hay; James J. Anderson; Larry J. Webe ..., Proceedings of the National Academy of Sciences current issue, 2014

Navigating obstacles is innate to fish in rivers, but fragmentation of the world’s rivers by more than 50,000 large dams threatens many of the fish migrations these waterways support. One limitation to mitigating the impacts of dams on fish is that we have a poor understanding of why some fish...

more

Nkx6.1 regulates islet {beta}-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors [Cell Biology]

08-04-2014 | Jeffery S. Tessem; Larry G. Moss; Lily C. Chao; Michelle Arlotto; Danhong Lu; Mette V. Jensen; Samuel B. Stephens; P ..., Proceedings of the National Academy of Sciences current issue, 2014

Loss of functional β-cell mass is a hallmark of type 1 and type 2 diabetes, and methods for restoring these cells are needed. We have previously reported that overexpression of the homeodomain transcription factor NK6 homeobox 1 (Nkx6.1) in rat pancreatic islets induces β-cell proliferation and ...

more

Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium [Medical Sciences]

08-04-2014 | Marcelo M. Nociari; Guillermo L. Lehmann; Andres E. Perez Bay; Roxana A. Radu; Zhichun Jiang; Shelby Goicochea; Ryan ..., Proceedings of the National Academy of Sciences current issue, 2014

Accumulation of lipofuscin bisretinoids (LBs) in the retinal pigment epithelium (RPE) is the alleged cause of retinal degeneration in genetic blinding diseases (e.g., Stargardt) and a possible etiological agent for age-related macular degeneration. Currently, there are no approved treatments for ...

more

On the origin of enhanced sensitivity in nanoscale FET-based biosensors [Engineering]

08-04-2014 | Kaveh Shoorideh; Chi On Chui, Proceedings of the National Academy of Sciences current issue, 2014

Electrostatic counter ion screening is a phenomenon that is detrimental to the sensitivity of charge detection in electrolytic environments, such as in field-effect transistor-based biosensors. Using simple analytical arguments, we show that electrostatic screening is weaker in the vicinity of ...

more

Origin, inheritance, and gene regulatory consequences of genome dominance in polyploids [Evolution]

08-04-2014 | Margaret R. Woodhouse; Feng Cheng; J. Chris Pires; Damon Lisch; Michael Freeling; Xiaowu Wang, Proceedings of the National Academy of Sciences current issue, 2014

Whole-genome duplications happen repeatedly in a typical flowering plant lineage. Following most ancient tetraploidies, the two subgenomes are distinguishable because one subgenome, the dominant subgenome, tends to have more genes than the other subgenome. Additionally, among retained pairs, the ...

more

Strain-specific parallel evolution drives short-term diversification during Pseudomonas aeruginosa biofilm formation [Microbiology]

08-04-2014 | Kerensa E. McElroy; Janice G. K. Hui; Jerry K. K. Woo; Alison W. S. Luk; Jeremy S. Webb; Staffan Kjelleberg; Scott A ..., Proceedings of the National Academy of Sciences current issue, 2014

Generation of genetic diversity is a prerequisite for bacterial evolution and adaptation. Short-term diversification and selection within populations is, however, largely uncharacterised, as existing studies typically focus on fixed substitutions. Here, we use whole-genome deep-sequencing to ...

more

In vivo radiation response of proneural glioma characterized by protective p53 transcriptional program and proneural-mesenchymal shift [Cell Biology]

08-04-2014 | John Halliday; Karim Helmy; Siobhan S. Pattwell; Kenneth L. Pitter; Quincey LaPlant; Tatsuya Ozawa; Eric C. Holland, Proceedings of the National Academy of Sciences current issue, 2014

Glioblastoma is the most common adult primary brain tumor and has a dismal median survival. Radiation is a mainstay of treatment and significantly improves survival, yet recurrence is nearly inevitable. Better understanding the radiation response of glioblastoma will help improve strategies to ...

more

Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1 [Physics]

08-04-2014 | Sagi Tamir; Shahar Rotem-Bamberger; Chen Katz; Faruck Morcos; Kendra L. Hailey; John A. Zuris; Charles Wang; Andrea ..., Proceedings of the National Academy of Sciences current issue, 2014

Life requires orchestrated control of cell proliferation, cell maintenance, and cell death. Involved in these decisions are protein complexes that assimilate a variety of inputs that report on the status of the cell and lead to an output response. Among the proteins involved in this response are ...

more

Crenolanib is a selective type I pan-FLT3 inhibitor [Medical Sciences]

08-04-2014 | Catherine Choy Smith; Elisabeth A. Lasater; Kimberly C. Lin; Qi Wang; Melissa Quino McCreery; Whitney K. Stewart; La ..., Proceedings of the National Academy of Sciences current issue, 2014

Tyrosine kinase inhibitors (TKIs) represent transformative therapies for several malignancies. Two critical features necessary for maximizing TKI tolerability and response duration are kinase selectivity and invulnerability to resistance-conferring kinase domain (KD) mutations in the intended ...

more

Page 1 From 1348
Subscribe to e-mail updates relating to your search

You will receive via e-mail the latest search results matching your search criteria. This service is free of charge and can be cancelled at any time.

Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE