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17,673 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

Glycosphingolipids are modulators of disease pathogenesis in amyotrophic lateral sclerosis [Neuroscience]

30-Jun-2015 | James C. Dodge; Christopher M. Treleaven; Joshua Pacheco; Samantha Cooper; Channa Bao; Marissa Abraham; Mandy Cromwe ..., Proceedings of the National Academy of Sciences current issue, 2015

Recent genetic evidence suggests that aberrant glycosphingolipid metabolism plays an important role in several neuromuscular diseases including hereditary spastic paraplegia, hereditary sensory neuropathy type 1, and non-5q spinal muscular atrophy. Here, we investigated whether altered ...

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Dynamic reorganization of human resting-state networks during visuospatial attention [Neuroscience]

30-Jun-2015 | Sara Spadone; Stefania Della Penna; Carlo Sestieri; Viviana Betti; Annalisa Tosoni; Mauro Gianni Perrucci; Gian Luca ..., Proceedings of the National Academy of Sciences current issue, 2015

Fundamental problems in neuroscience today are understanding how patterns of ongoing spontaneous activity are modified by task performance and whether/how these intrinsic patterns influence task-evoked activation and behavior. We examined these questions by comparing instantaneous functional ...

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Osborne Reynolds pipe flow: Direct simulation from laminar through gradual transition to fully developed turbulence [Engineering]

30-Jun-2015 | Xiaohua Wu; Parviz Moin; Ronald J. Adrian; Jon R. Baltzer, Proceedings of the National Academy of Sciences current issue, 2015

The precise dynamics of breakdown in pipe transition is a century-old unresolved problem in fluid mechanics. We demonstrate that the abruptness and mysteriousness attributed to the Osborne Reynolds pipe transition can be partially resolved with a spatially developing direct simulation that ...

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Correction for Stoveken et al., Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist [Correction]

30-Jun-2015 | Proceedings of the National Academy of Sciences current issue, 2015

PHARMACOLOGY Correction for “Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist,” by Hannah M. Stoveken, Alexander G. Hajduczok, Lei Xu, and Gregory G. Tall, which appeared in issue 19, May 12, 2015, of Proc Natl Acad Sci USA (112:6194–6199; first ...

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Transcriptomics of critical period of visual cortical plasticity in mice [Neuroscience]

30-Jun-2015 | Jamie Benoit; Albert E. Ayoub; Pasko Rakic, Proceedings of the National Academy of Sciences current issue, 2015

In contrast to the prenatal development of the cerebral cortex, when cell production, migration, and layer formation dominate, development after birth involves more subtle processes, such as activity-dependent plasticity that includes refinement of synaptic connectivity by its stabilization and ...

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Reduction of toxic RNAs in myotonic dystrophies type 1 and type 2 by the RNA helicase p68/DDX5 [Genetics]

30-Jun-2015 | Karlie Jones; Christina Wei; Benedikt Schoser; Giovanni Meola; Nikolai Timchenko; Lubov Timchenko, Proceedings of the National Academy of Sciences current issue, 2015

Myotonic dystrophies type 1 (DM1) and type 2 (DM2) are neuromuscular diseases, caused by accumulation of CUG and CCUG RNAs in toxic aggregates. Here we report that the increased stability of the mutant RNAs in both types of DM is caused by deficiency of RNA helicase p68. We have identified...

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Nuclear matrix-associated protein SMAR1 regulates alternative splicing via HDAC6-mediated deacetylation of Sam68 [Cell Biology]

30-Jun-2015 | Kiran Kumar Nakka; Nidhi Chaudhary; Shruti Joshi; Jyotsna Bhat; Kulwant Singh; Subhrangsu Chatterjee; Renu Malhotra; ..., Proceedings of the National Academy of Sciences current issue, 2015

Pre-mRNA splicing is a complex regulatory nexus modulated by various trans-factors and their posttranslational modifications to create a dynamic transcriptome through alternative splicing. Signal-induced phosphorylation and dephosphorylation of trans-factors are known to regulate alternative ...

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Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens [Neuroscience]

30-Jun-2015 | Jung Hoon Shin; Martín F. Adrover; Jürgen Wess; Veronica A. Alvarez, Proceedings of the National Academy of Sciences current issue, 2015

Cholinergic transmission in the striatum functions as a key modulator of dopamine (DA) transmission and synaptic plasticity, both of which are required for reward and motor learning. Acetylcholine (ACh) can elicit striatal DA release through activation of nicotinic ACh receptors (nAChRs) on DA ...

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Influence of support morphology on the bonding of molecules to nanoparticles [Chemistry]

30-Jun-2015 | Chi Ming Yim; Chi L. Pang; Diego R. Hermoso; Coinneach M. Dover; Christopher A. Muryn; Francesco Maccherozzi; Sarnje ..., Proceedings of the National Academy of Sciences current issue, 2015

Supported metal nanoparticles form the basis of heterogeneous catalysts. Above a certain nanoparticle size, it is generally assumed that adsorbates bond in an identical fashion as on a semiinfinite crystal. This assumption has allowed the database on metal single crystals accumulated over the ...

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Correction for Campbell et al., Humoral response to a viral glycan correlates with survival on PROSTVAC-VF [Correction]

30-Jun-2015 | Proceedings of the National Academy of Sciences current issue, 2015

MEDICAL SCIENCES Correction for “Humoral response to a viral glycan correlates with survival on PROSTVAC-VF,” by Christopher T. Campbell, James L. Gulley, Oyindasola Oyelaran, James W. Hodge, Jeffrey Schlom, and Jeffrey C. Gildersleeve, which appeared in issue 17, April 29, 2014, of Proc Natl ...

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