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15,343 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

Dynamical traps lead to the slowing down of intramolecular vibrational energy flow [Chemistry]

07-10-2014 | Paranjothy Manikandan; Srihari Keshavamurthy, Proceedings of the National Academy of Sciences current issue, 2014

The phenomenon of intramolecular vibrational energy redistribution (IVR) is at the heart of chemical reaction dynamics. Statistical rate theories, assuming instantaneous IVR, predict exponential decay of the population with the properties of the transition state essentially determining the ...

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Dynamic measurements for funny channels [Physiology]

07-10-2014 | Michael C. Puljung, Proceedings of the National Academy of Sciences current issue, 2014

Proteins possess the uncanny ability to telegraph signals over long distances. The presence of a ligand, snugly bound to a site on one end of a molecule, can be “felt” by an effector domain several nanometers away. Determining precisely how this task is accomplished is a major challenge for ...

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Deleting titin's I-band/A-band ȷunction reveals critical roles for titin in biomechanical sensing and cardiac function [Physiology]

07-10-2014 | Henk L. Granzier; Kirk R. Hutchinson; Paola Tonino; Mei Methawasin; Frank W. Li; Rebecca E. Slater; Mathew M. Bull; ..., Proceedings of the National Academy of Sciences current issue, 2014

Titin, the largest protein known, forms a giant filament in muscle where it spans the half sarcomere from Z disk to M band. Here we genetically targeted a stretch of 14 immunoglobulin-like and fibronectin type 3 domains that comprises the I-band/A-band (IA) junction and obtained a viable mouse ...

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Novel coding, translation, and gene expression of a replicating covalently closed circular RNA of 220 nt [Microbiology]

07-10-2014 | Mounir Georges AbouHaidar; Srividhya Venkataraman; Ashkan Golshani; Bolin Liu; Tauqeer Ahmad, Proceedings of the National Academy of Sciences current issue, 2014

The highly structured (64% GC) covalently closed circular (CCC) RNA (220 nt) of the virusoid associated with rice yellow mottle virus codes for a 16-kDa highly basic protein using novel modalities for coding, translation, and gene expression. This CCC RNA is the smallest among all known viroids ...

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Basis for substrate recognition and distinction by matrix metalloproteinases [Biochemistry]

07-10-2014 | Boris I. Ratnikov; Piotr Cieplak; Kosi Gramatikoff; James Pierce; Alexey Eroshkin; Yoshinobu Igarashi; Marat Kazanov ..., Proceedings of the National Academy of Sciences current issue, 2014

Genomic sequencing and structural genomics produced a vast amount of sequence and structural data, creating an opportunity for structure–function analysis in silico [Radivojac P, et al. (2013) Nat Methods 10(3):221–227]. Unfortunately, only a few large experimental datasets exist to serve as ...

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Emergence of long-range order in sheets of magnetic dimers [Physics]

07-10-2014 | S. Haravifard; A. Banerjee; J. van Wezel; D. M. Silevitch; A. M. dos Santos; J. C. Lang; E. Kermarrec; G. Srajer; B. ..., Proceedings of the National Academy of Sciences current issue, 2014

Quantum spins placed on the corners of a square lattice can dimerize and form singlets, which then can be transformed into a magnetic state as the interactions between dimers increase beyond threshold. This is a strictly 2D transition in theory, but real-world materials often need the third ...

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Bimodal activation of BubR1 by Bub3 sustains mitotic checkpoint signaling [Cell Biology]

07-10-2014 | Joo Seok Han; Benjamin Vitre; Daniele Fachinetti; Don W. Cleveland, Proceedings of the National Academy of Sciences current issue, 2014

The mitotic checkpoint (also known as the spindle assembly checkpoint) prevents premature anaphase onset through generation of an inhibitor of the E3 ubiquitin ligase APC/C, whose ubiquitination of cyclin B and securin targets them for degradation. Combining in vitro reconstitution and cell-based ...

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Scaling description of the yielding transition in soft amorphous solids at zero temperature [Physics]

07-10-2014 | Jie Lin; Edan Lerner; Alberto Rosso; Matthieu Wyart, Proceedings of the National Academy of Sciences current issue, 2014

Yield stress materials flow if a sufficiently large shear stress is applied. Although such materials are ubiquitous and relevant for industry, there is no accepted microscopic description of how they yield, even in the simplest situations in which temperature is negligible and in which flow ...

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The cardiac-specific N-terminal region of troponin I positions the regulatory domain of troponin C [Biochemistry]

07-10-2014 | Peter M. Hwang; Fangze Cai; Sandra E. Pineda-Sanabria; David C. Corson; Brian D. Sykes, Proceedings of the National Academy of Sciences current issue, 2014

The cardiac isoform of troponin I (cTnI) has a unique 31-residue N-terminal region that binds cardiac troponin C (cTnC) to increase the calcium sensitivity of the sarcomere. The interaction can be abolished by cTnI phosphorylation at Ser22 and Ser23, an important mechanism for regulating cardiac ...

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Beclin-1 deficiency in the murine ovary results in the reduction of progesterone production to promote preterm labor [Developmental Biology]

07-10-2014 | Thomas R. Gawriluk; CheMyong Ko; Xiaoman Hong; Lane K. Christenson; Edmund B. Rucker III, Proceedings of the National Academy of Sciences current issue, 2014

Autophagy is an important cellular process that serves as a companion pathway to the ubiquitin-proteasome system to degrade long-lived proteins and organelles to maintain cell homeostasis. Although initially characterized in yeast, autophagy is being realized as an important regulator of ...

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