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19,818 Newest Publications in proceedings of the national academy of sciences current issue

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Stage-specific embryonic antigen-3 (SSEA-3) and {beta}3GalT5 are cancer specific and significant markers for breast cancer stem cells [Biochemistry]

26-Jan-2016 | Sarah K. C. Cheung; Po-Kai Chuang; Han-Wen Huang; Wendy W. Hwang-Verslues; Candy Hsin-Hua Cho; Wen-Bin Yang; Chia-Ni ..., Proceedings of the National Academy of Sciences current issue, 2016

The discovery of cancer stem cells (CSCs), which are responsible for self-renewal and tumor growth in heterogeneous cancer tissues, has stimulated interests in developing new cancer therapies and early diagnosis. However, the markers currently used for isolation of CSCs are often not selective ...

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Stochastic modeling reveals an evolutionary mechanism underlying elevated rates of childhood leukemia [Medical Sciences]

26-Jan-2016 | Andrii I. Rozhok; Jennifer L. Salstrom; James DeGregori, Proceedings of the National Academy of Sciences current issue, 2016

Young children have higher rates of leukemia than young adults. This fact represents a fundamental conundrum, because hematopoietic cells in young children should have fewer mutations (including oncogenic ones) than such cells in adults. Here, we present the results of stochastic modeling of ...

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Sea otters, kelp forests, and the extinction of Steller’s sea cow [Ecology]

26-Jan-2016 | James A. Estes; Alexander Burdin; Daniel F. Doak, Proceedings of the National Academy of Sciences current issue, 2016

The late Pleistocene extinction of so many large-bodied vertebrates has been variously attributed to two general causes: rapid climate change and the effects of humans as they spread from the Old World to previously uninhabited continents and islands. Many large-bodied vertebrates, especially ...

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The point of no return in vetoing self-initiated movements [Neuroscience]

26-Jan-2016 | Matthias Schultze-Kraft; Daniel Birman; Marco Rusconi; Carsten Allefeld; Kai Görgen; Sven Dähne; Benjamin Blankertz; ..., Proceedings of the National Academy of Sciences current issue, 2016

In humans, spontaneous movements are often preceded by early brain signals. One such signal is the readiness potential (RP) that gradually arises within the last second preceding a movement. An important question is whether people are able to cancel movements after the elicitation of such RPs, ...

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Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies [Medical Sciences]

26-Jan-2016 | David T. Rodgers; Magdalena Mazagova; Eric N. Hampton; Yu Cao; Nitya S. Ramadoss; Ian R. Hardy; Andrew Schulman; Jua ..., Proceedings of the National Academy of Sciences current issue, 2016

Chimeric antigen receptor T (CAR-T) cell therapy has produced impressive results in clinical trials for B-cell malignancies. However, safety concerns related to the inability to control CAR-T cells once infused into the patient remain a significant challenge. Here we report the engineering of ...

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Global nutrient transport in a world of giants [Ecology]

26-Jan-2016 | Christopher E. Doughty; Joe Roman; Søren Faurby; Adam Wolf; Alifa Haque; Elisabeth S. Bakker; Yadvinder Malhi; John ..., Proceedings of the National Academy of Sciences current issue, 2016

The past was a world of giants, with abundant whales in the sea and large animals roaming the land. However, that world came to an end following massive late-Quaternary megafauna extinctions on land and widespread population reductions in great whale populations over the past few centuries. These ...

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Covert digital manipulation of vocal emotion alter speakers’ emotional states in a congruent direction [Psychological and Cognitive Sciences]

26-Jan-2016 | Jean-Julien Aucouturier; Petter Johansson; Lars Hall; Rodrigo Segnini; Lolita Mercadié; Katsumi Watanabe, Proceedings of the National Academy of Sciences current issue, 2016

Research has shown that people often exert control over their emotions. By modulating expressions, reappraising feelings, and redirecting attention, they can regulate their emotional experience. These findings have contributed to a blurring of the traditional boundaries between cognitive and ...

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Structure and stabilization of the Hendra virus F glycoprotein in its prefusion form [Microbiology]

26-Jan-2016 | Joyce J. W. Wong; Reay G. Paterson; Robert A. Lamb; Theodore S. Jardetzky, Proceedings of the National Academy of Sciences current issue, 2016

Hendra virus (HeV) is one of the two prototypical members of the Henipavirus genus of paramyxoviruses, which are designated biosafety level 4 (BSL-4) organisms due to the high mortality rate of Nipah virus (NiV) and HeV in humans. Paramyxovirus cell entry is mediated by the fusion protein, F, in ...

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Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution [Immunology and Inflammation]

26-Jan-2016 | Yun-Hee Youm; Tamas L. Horvath; David J. Mangelsdorf; Steven A. Kliewer; Vishwa Deep Dixit, Proceedings of the National Academy of Sciences current issue, 2016

Age-related thymic degeneration is associated with loss of naïve T cells, restriction of peripheral T-cell diversity, and reduced healthspan due to lower immune competence. The mechanistic basis of age-related thymic demise is unclear, but prior evidence suggests that caloric restriction (CR) can ...

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Megafauna and ecosystem function from the Pleistocene to the Anthropocene [Biological Sciences]

26-Jan-2016 | Yadvinder Malhi; Christopher E. Doughty; Mauro Galetti; Felisa A. Smith; Jens-Christian Svenning; John W. Terborgh, Proceedings of the National Academy of Sciences current issue, 2016

Large herbivores and carnivores (the megafauna) have been in a state of decline and extinction since the Late Pleistocene, both on land and more recently in the oceans. Much has been written on the timing and causes of these declines, but only recently has scientific attention focused on the ...

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