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16,515 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

Visual Turing test for computer vision systems [Computer Sciences]

24-Mar-2015 | Donald Geman; Stuart Geman; Neil Hallonquist; Laurent Younes, Proceedings of the National Academy of Sciences current issue, 2015

Today, computer vision systems are tested by their accuracy in detecting and localizing instances of objects. As an alternative, and motivated by the ability of humans to provide far richer descriptions and even tell a story about an image, we construct a “visual Turing test”: an ...

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ORMDL orosomucoid-like proteins are degraded by free-cholesterol-loading-induced autophagy [Cell Biology]

24-Mar-2015 | Shuhui Wang; Peggy Robinet; Jonathan D. Smith; Kailash Gulshan, Proceedings of the National Academy of Sciences current issue, 2015

Eukaryotic cells have evolved robust mechanisms to counter excess cholesterol including redistribution of lipids into different compartments and compensatory up-regulation of phospholipid biosynthesis. We demonstrate here that excess cellular cholesterol increased the activity of the endoplasmic ...

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A TOCA/CDC-42/PAR/WAVE functional module required for retrograde endocytic recycling [Cell Biology]

24-Mar-2015 | Zhiyong Bai; Barth D. Grant, Proceedings of the National Academy of Sciences current issue, 2015

Endosome-to-Golgi transport is required for the function of many key membrane proteins and lipids, including signaling receptors, small-molecule transporters, and adhesion proteins. The retromer complex is well-known for its role in cargo sorting and vesicle budding from early endosomes, in most ...

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Emerging picture of the distinct traits and functions of microvesicles and exosomes [Cell Biology]

24-Mar-2015 | Marc A. Antonyak; Richard A. Cerione, Proceedings of the National Academy of Sciences current issue, 2015

The ability of a cell to receive signals from other cells and then translate them into changes in cell behavior plays crucial roles in development and tissue homeostasis. However, the deregulation of these carefully orchestrated events underlie the onset or progression of several diseases in the ...

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Different personal propensities among scientists relate to deeper vs. broader knowledge contributions [Psychological and Cognitive Sciences]

24-Mar-2015 | Thomas S. Bateman; Andrew M. Hess, Proceedings of the National Academy of Sciences current issue, 2015

Scientific journal publications, and their contributions to knowledge, can be described by their depth (specialized, domain-specific knowledge extensions) and breadth (topical scope, including spanning multiple knowledge domains). Toward generating hypotheses about how scientists’ personal ...

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Regulation of Nrf2 signaling and longevity in naturally long-lived rodents [Cell Biology]

24-Mar-2015 | Kaitlyn N. Lewis; Emily Wason; Yael H. Edrey; Deborah M. Kristan; Eviatar Nevo; Rochelle Buffenstein, Proceedings of the National Academy of Sciences current issue, 2015

The preternaturally long-lived naked mole-rat, like other long-lived species and experimental models of extended longevity, is resistant to both endogenous (e.g., reactive oxygen species) and environmental stressors and also resists age-related diseases such as cancer, cardiovascular disease, and ...

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Latent structure in random sequences drives neural learning toward a rational bias [Psychological and Cognitive Sciences]

24-Mar-2015 | Yanlong Sun; Randall C. O’Reilly; Rajan Bhattacharyya; Jack W. Smith; Xun Liu; Hongbin Wang, Proceedings of the National Academy of Sciences current issue, 2015

People generally fail to produce random sequences by overusing alternating patterns and avoiding repeating ones—the gambler’s fallacy bias. We can explain the neural basis of this bias in terms of a biologically motivated neural model that learns from errors in predicting what will happen next. ...

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Dysfunctional conformational dynamics of protein kinase A induced by a lethal mutant of phospholamban hinder phosphorylation [Biophysics and Computational Biology]

24-Mar-2015 | Jonggul Kim; Larry R. Masterson; Alessandro Cembran; Raffaello Verardi; Lei Shi; Jiali Gao; Susan S. Taylor; Gianlui ..., Proceedings of the National Academy of Sciences current issue, 2015

The dynamic interplay between kinases and substrates is crucial for the formation of catalytically committed complexes that enable phosphoryl transfer. However, a clear understanding on how substrates modulate kinase structural dynamics to control catalytic efficiency is still missing. Here, we ...

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Stable solar-driven oxidation of water by semiconducting photoanodes protected by transparent catalytic nickel oxide films [Chemistry]

24-Mar-2015 | Ke Sun; Fadl H. Saadi; Michael F. Lichterman; William G. Hale; Hsin-Ping Wang; Xinghao Zhou; Noah T. Plymale; Stefan ..., Proceedings of the National Academy of Sciences current issue, 2015

Reactively sputtered nickel oxide (NiOx) films provide transparent, antireflective, electrically conductive, chemically stable coatings that also are highly active electrocatalysts for the oxidation of water to O2(g). These NiOx coatings provide protective layers on a variety of technologically ...

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Allelic polymorphism of GIGANTEA is responsible for naturally occurring variation in circadian period in Brassica rapa [Plant Biology]

24-Mar-2015 | Qiguang Xie; Ping Lou; Victor Hermand; Rashid Aman; Hee Jin Park; Dae-Jin Yun; Woe Yeon Kim; Matti Juhani Salmela; B ..., Proceedings of the National Academy of Sciences current issue, 2015

GIGANTEA (GI) was originally identified by a late-flowering mutant in Arabidopsis, but subsequently has been shown to act in circadian period determination, light inhibition of hypocotyl elongation, and responses to multiple abiotic stresses, including tolerance to high salt and cold (freezing) ...

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