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15,328 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

Role of Erbin in ErbB2-dependent breast tumor growth [Cell Biology]

21-10-2014 | Yanmei Tao; Chengyong Shen; Shiwen Luo; Wilfried Traoré; Sylvie Marchetto; Marie-Josée Santoni; Linlin Xu; Biao Wu; ..., Proceedings of the National Academy of Sciences current issue, 2014

ErbB2 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2), a receptor tyrosine kinase of the ErbB family, is overexpressed in around 25% of breast cancers. In addition to forming a heterodimer with other ErbB receptors in response to ligand stimulation, ErbB2 can be activated in a ...

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In This Issue [This Week in PNAS]

21-10-2014 | Proceedings of the National Academy of Sciences current issue, 2014

Efficient catalysis of CO2 to CO Conversion of CO2 to CO, an initial step in manufacturing liquid fuels from CO2, requires catalysts that are usually composed of transition metal complexes. To improve the efficiency of CO2-to-CO electrochemical catalysts, Cyrille Costentin et al. (pp. ...

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Following movement of domain IV of elongation factor G during ribosomal translocation [Biochemistry]

21-10-2014 | Enea Salsi; Elie Farah; Jillian Dann; Dmitri N. Ermolenko, Proceedings of the National Academy of Sciences current issue, 2014

Translocation of mRNA and tRNAs through the ribosome is catalyzed by a universally conserved elongation factor (EF-G in prokaryotes and EF-2 in eukaryotes). Previous studies have suggested that ribosome-bound EF-G undergoes significant structural rearrangements. Here, we follow the movement of ...

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GABAB(1) receptor subunit isoforms differentially regulate stress resilience [Neuroscience]

21-10-2014 | Olivia F. O’Leary; Daniela Felice; Stefano Galimberti; Hélène M. Savignac; Javier A. Bravo; Tadhg Crowley; Malika El ..., Proceedings of the National Academy of Sciences current issue, 2014

Stressful life events increase the susceptibility to developing psychiatric disorders such as depression; however, many individuals are resilient to such negative effects of stress. Determining the neurobiology underlying this resilience is instrumental to the development of novel and more ...

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Sexual selection on wing interference patterns in Drosophila melanogaster [Evolution]

21-10-2014 | Natsu Katayama; Jessica K. Abbott; Jostein Kjærandsen; Yuma Takahashi; Erik I. Svensson, Proceedings of the National Academy of Sciences current issue, 2014

Animals with color vision use color information in intra- and interspecific communication, which in turn may drive the evolution of conspicuous colored body traits via natural and sexual selection. A recent study found that the transparent wings of small flies and wasps in lower-reflectance light ...

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Application of desorption electrospray ionization mass spectrometry imaging in breast cancer margin analysis [Chemistry]

21-10-2014 | David Calligaris; Diana Caragacianu; Xiaohui Liu; Isaiah Norton; Christopher J. Thompson; Andrea L. Richardson; Mehr ..., Proceedings of the National Academy of Sciences current issue, 2014

Distinguishing tumor from normal glandular breast tissue is an important step in breast-conserving surgery. Because this distinction can be challenging in the operative setting, up to 40% of patients require an additional operation when traditional approaches are used. Here, we present a ...

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PGC-1{beta} promotes enterocyte lifespan and tumorigenesis in the intestine [Medical Sciences]

21-10-2014 | Elena Bellafante; Annalisa Morgano; Lorena Salvatore; Stefania Murzilli; Giuseppe Di Tullio; Andria D’Orazio; Doming ..., Proceedings of the National Academy of Sciences current issue, 2014

The mucosa of the small intestine is renewed completely every 3–5 d throughout the entire lifetime by small populations of adult stem cells that are believed to reside in the bottom of the crypts and to migrate and differentiate into all the different populations of intestinal cells. When the ...

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Reply to Leithner et al.: Focus on phopshoenolpyruvate carboxykinase (PEPCK): A target of the p53-SIRT6-FoxO1 axis [Biological Sciences]

21-10-2014 | Zhiming Li; Wei-Guo Zhu, Proceedings of the National Academy of Sciences current issue, 2014

Cancer metabolism has drawn widespread attention since the unique metabolic properties of cancer cells were characterized. We found that p53, a potent tumor suppressor, down-regulates the expression of phopshoenolpyruvate carboxykinase (PEPCK, PCK1) in coordination with histone deacetylase ...

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Reply to Cheung et al.: The cognitive map hypothesis remains the best interpretation of the data in honeybee navigation [Biological Sciences]

21-10-2014 | James F. Cheeseman; Craig D. Millar; Uwe Greggers; Konstantin Lehmann; Matthew D. M. Pawley; Charles R. Gallistel; G ..., Proceedings of the National Academy of Sciences current issue, 2014

Cheung et al. (1) criticize two points of our study, both of which are unfounded. The first is that general anesthesia is not shifting the clock controlling sun compass orientation in bees. This is clearly wrong. We show that sun compass orientation and food anticipatory behavior are ...

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Defects in T-tubular electrical activity underlie local alterations of calcium release in heart failure [Medical Sciences]

21-10-2014 | Claudia Crocini; Raffaele Coppini; Cecilia Ferrantini; Ping Yan; Leslie M. Loew; Chiara Tesi; Elisabetta Cerbai; Cor ..., Proceedings of the National Academy of Sciences current issue, 2014

Action potentials (APs), via the transverse axial tubular system (TATS), synchronously trigger uniform Ca2+ release throughout the cardiomyocyte. In heart failure (HF), TATS structural remodeling occurs, leading to asynchronous Ca2+ release across the myocyte and contributing to contractile ...

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