My watch list
my.chemeurope.com  
Login  

17,493 Newest Publications in proceedings of the national academy of sciences current issue

rss
matching the following criteria

Alleviation of off-target effects from vector-encoded shRNAs via codelivered RNA decoys [Applied Biological Sciences]

28-Jul-2015 | Stefan Mockenhaupt; Stefanie Grosse; Daniel Rupp; Ralf Bartenschlager; Dirk Grimm, Proceedings of the National Academy of Sciences current issue, 2015

Exogenous RNAi triggers such as shRNAs ideally exert their activities exclusively via the antisense strand that binds and silences designated target mRNAs. However, in principle, the sense strand also possesses silencing capacity that may contribute to adverse RNAi side effects including ...

more

Distinct speed dependence of entorhinal island and ocean cells, including respective grid cells [Neuroscience]

28-Jul-2015 | Chen Sun; Takashi Kitamura; Jun Yamamoto; Jared Martin; Michele Pignatelli; Lacey J. Kitch; Mark J. Schnitzer; Susum ..., Proceedings of the National Academy of Sciences current issue, 2015

Entorhinal–hippocampal circuits in the mammalian brain are crucial for an animal’s spatial and episodic experience, but the neural basis for different spatial computations remain unknown. Medial entorhinal cortex layer II contains pyramidal island and stellate ocean cells. Here, we performed cell ...

more

Evolutionary rewiring of gene regulatory network linkages at divergence of the echinoid subclasses [Evolution]

28-Jul-2015 | Eric M. Erkenbrack; Eric H. Davidson, Proceedings of the National Academy of Sciences current issue, 2015

Evolution of animal body plans occurs with changes in the encoded genomic programs that direct development, by alterations in the structure of encoded developmental gene-regulatory networks (GRNs). However, study of this most fundamental of evolutionary processes requires experimentally ...

more

High-throughput analysis of yeast replicative aging using a microfluidic system [Cell Biology]

28-Jul-2015 | Myeong Chan Jo; Wei Liu; Liang Gu; Weiwei Dang; Lidong Qin, Proceedings of the National Academy of Sciences current issue, 2015

Saccharomyces cerevisiae has been an important model for studying the molecular mechanisms of aging in eukaryotic cells. However, the laborious and low-throughput methods of current yeast replicative lifespan assays limit their usefulness as a broad genetic screening platform for research on ...

more

Functional expression of sodium-glucose transporters in cancer [Medical Sciences]

28-Jul-2015 | Claudio Scafoglio; Bruce A. Hirayama; Vladimir Kepe; Jie Liu; Chiara Ghezzi; Nagichettiar Satyamurthy; Neda A. Moata ..., Proceedings of the National Academy of Sciences current issue, 2015

Glucose is a major metabolic substrate required for cancer cell survival and growth. It is mainly imported into cells by facilitated glucose transporters (GLUTs). Here we demonstrate the importance of another glucose import system, the sodium-dependent glucose transporters (SGLTs), in pancreatic ...

more

Active and widespread halogen chemistry in the tropical and subtropical free troposphere [Earth, Atmospheric, and Planetary Sciences]

28-Jul-2015 | Siyuan Wang; Johan A. Schmidt; Sunil Baidar; Sean Coburn; Barbara Dix; Theodore K. Koenig; Eric Apel; Dene Bowdalo; ..., Proceedings of the National Academy of Sciences current issue, 2015

Halogens in the troposphere are increasingly recognized as playing an important role for atmospheric chemistry, and possibly climate. Bromine and iodine react catalytically to destroy ozone (O3), oxidize mercury, and modify oxidative capacity that is relevant for the lifetime of greenhouse gases. ...

more

Multiethnicity, pluralism, and migration in the south central Andes: An alternate path to state expansion [Social Sciences]

28-Jul-2015 | Paul S. Goldstein, Proceedings of the National Academy of Sciences current issue, 2015

The south central Andes is known as a region of enduring multiethnic diversity, yet it is also the cradle of one the South America’s first successful expansive-state societies. Social structures that encouraged the maintenance of separate identities among coexistent ethnic groups may explain this ...

more

Conformational kinetics reveals affinities of protein conformational states [Biophysics and Computational Biology]

28-Jul-2015 | Kyle G. Daniels; Yang Suo; Terrence G. Oas, Proceedings of the National Academy of Sciences current issue, 2015

Most biological reactions rely on interplay between binding and changes in both macromolecular structure and dynamics. Practical understanding of this interplay requires detection of critical intermediates and determination of their binding and conformational characteristics. However, many of ...

more

Reply to Liu et al.: HNF4A and PTBP1 expression in the brain of neurodegenerative disease patients [Biological Sciences]

28-Jul-2015 | Jose A. Santiago; Judith A. Potashkin, Proceedings of the National Academy of Sciences current issue, 2015

We thank Liu et al. (1) for their comments on our manuscript in which hepatocyte nuclear factor 4 alpha (HNF4A) and polypyrimidine tract binding protein 1 (PTBP1) are identified as potential dynamic biomarkers for Parkinson’s disease (PD) (2). In our study, transcriptomic and network-based ...

more

Formation of surface nanodroplets under controlled flow conditions [Applied Physical Sciences]

28-Jul-2015 | Xuehua Zhang; Ziyang Lu; Huanshu Tan; Lei Bao; Yinghe He; Chao Sun; Detlef Lohse, Proceedings of the National Academy of Sciences current issue, 2015

Nanodroplets on a solid surface (i.e., surface nanodroplets) have practical implications for high-throughput chemical and biological analysis, lubrications, laboratory-on-chip devices, and near-field imaging techniques. Oil nanodroplets can be produced on a solid–liquid interface in a simple step ...

more

Page 1 From 1750
Subscribe to e-mail updates relating to your search

You will receive via e-mail the latest search results matching your search criteria. This service is free of charge and can be cancelled at any time.

Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE