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17,243 Newest Publications in proceedings of the national academy of sciences current issue

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Correction for Sagi et al., Nitric oxide regulates synaptic transmission between spiny projection neurons [Correction]

07-Apr-2015 | Proceedings of the National Academy of Sciences current issue, 2015

NEUROSCIENCE Correction for “Nitric oxide regulates synaptic transmission between spiny projection neurons,” by Yotam Sagi, Myriam Heiman, Jayms D. Peterson, Sergei Musatov, Michael G. Kaplitt, Dalton J. Surmeier, Nathaniel Heintz, and Paul Greengard, which appeared in issue 49, December 9, 2014, ...

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Trichodesmium genome maintains abundant, widespread noncoding DNA in situ, despite oligotrophic lifestyle [Evolution]

07-Apr-2015 | Nathan Walworth; Ulrike Pfreundt; William C. Nelson; Tracy Mincer; John F. Heidelberg; Feixue Fu; John B. Waterbury; ..., Proceedings of the National Academy of Sciences current issue, 2015

Understanding the evolution of the free-living, cyanobacterial, diazotroph Trichodesmium is of great importance because of its critical role in oceanic biogeochemistry and primary production. Unlike the other >150 available genomes of free-living cyanobacteria, only 63.8% of the Trichodesmium ...

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Carbon monoxide as a metabolic energy source for extremely halophilic microbes: Implications for microbial activity in Mars regolith [Microbiology]

07-Apr-2015 | Gary M. King, Proceedings of the National Academy of Sciences current issue, 2015

Carbon monoxide occurs at relatively high concentrations (≥800 parts per million) in Mars’ atmosphere, where it represents a potentially significant energy source that could fuel metabolism by a localized putative surface or near-surface microbiota. However, the plausibility of CO oxidation under ...

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Structural mechanisms of DNA binding and unwinding in bacterial RecQ helicases [Biochemistry]

07-Apr-2015 | Kelly A. Manthei; Morgan C. Hill; Jordan E. Burke; Samuel E. Butcher; James L. Keck, Proceedings of the National Academy of Sciences current issue, 2015

RecQ helicases unwind remarkably diverse DNA structures as key components of many cellular processes. How RecQ enzymes accommodate different substrates in a unified mechanism that couples ATP hydrolysis to DNA unwinding is unknown. Here, the X-ray crystal structure of the Cronobacter sakazakii ...

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N-Glycosylation as determinant of epidermal growth factor receptor conformation in membranes [Biophysics and Computational Biology]

07-Apr-2015 | Karol Kaszuba; Michał Grzybek; Adam Orłowski; Reinis Danne; Tomasz Róg; Kai Simons; Ünal Coskun; Ilpo Vattulainen, Proceedings of the National Academy of Sciences current issue, 2015

The epidermal growth factor receptor (EGFR) regulates several critical cellular processes and is an important target for cancer therapy. In lieu of a crystallographic structure of the complete receptor, atomistic molecular dynamics (MD) simulations have recently shown that they can excel in ...

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Multiplexed metagenome mining using short DNA sequence tags facilitates targeted discovery of epoxyketone proteasome inhibitors [Microbiology]

07-Apr-2015 | Jeremy G. Owen; Zachary Charlop-Powers; Alexandra G. Smith; Melinda A. Ternei; Paula Y. Calle; Boojala Vijay B. Redd ..., Proceedings of the National Academy of Sciences current issue, 2015

In molecular evolutionary analyses, short DNA sequences are used to infer phylogenetic relationships among species. Here we apply this principle to the study of bacterial biosynthesis, enabling the targeted isolation of previously unidentified natural products directly from complex metagenomes. ...

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Oncogenesis driven by the Ras/Raf pathway requires the SUMO E2 ligase Ubc9 [Cell Biology]

07-Apr-2015 | Bing Yu; Stephen Swatkoski; Alesia Holly; Liam C. Lee; Valentin Giroux; Chih-Shia Lee; Dennis Hsu; Jordan L. Smith; ..., Proceedings of the National Academy of Sciences current issue, 2015

The small GTPase KRAS is frequently mutated in human cancer and currently there are no targeted therapies for KRAS mutant tumors. Here, we show that the small ubiquitin-like modifier (SUMO) pathway is required for KRAS-driven transformation. RNAi depletion of the SUMO E2 ligase Ubc9 suppresses 3D ...

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Motion of proximal histidine and structural allosteric transition in soluble guanylate cyclase [Biochemistry]

07-Apr-2015 | Byung-Kuk Yoo; Isabelle Lamarre; Jean-Louis Martin; Fabrice Rappaport; Michel Negrerie, Proceedings of the National Academy of Sciences current issue, 2015

We investigated the changes of heme coordination in purified soluble guanylate cyclase (sGC) by time-resolved spectroscopy in a time range encompassing 11 orders of magnitude (from 1 ps to 0.2 s). After dissociation, NO either recombines geminately to the 4-coordinate (4c) heme (τG1 = 7.5 ps; 97 ...

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Evidence for indigenous nitrogen in sedimentary and aeolian deposits from the Curiosity rover investigations at Gale crater, Mars [Earth, Atmospheric, and Planetary Sciences]

07-Apr-2015 | Jennifer C. Stern; Brad Sutter; Caroline Freissinet; Rafael Navarro-González; Christopher P. McKay; P. Douglas Arche ..., Proceedings of the National Academy of Sciences current issue, 2015

The Sample Analysis at Mars (SAM) investigation on the Mars Science Laboratory (MSL) Curiosity rover has detected oxidized nitrogen-bearing compounds during pyrolysis of scooped aeolian sediments and drilled sedimentary deposits within Gale crater. Total N concentrations ranged from 20 to 250 ...

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Src-family protein tyrosine kinase phosphorylates WNK4 and modulates its inhibitory effect on KCNJ1 (ROMK) [Physiology]

07-Apr-2015 | Dao-Hong Lin; Peng Yue; Orlando Yarborough III; Ute I. Scholl; Gerhard Giebisch; Richard P. Lifton; Jesse Rinehart; ..., Proceedings of the National Academy of Sciences current issue, 2015

With-no-lysine kinase 4 (WNK4) inhibits the activity of the potassium channel KCNJ1 (ROMK) in the distal nephron, thereby contributing to the maintenance of potassium homeostasis. This effect is inhibited via phosphorylation at Ser1196 by serum/glucocorticoid-induced kinase 1 (SGK1), and this ...

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