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16,652 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

Disruption of hierarchical predictive coding during sleep [Neuroscience]

17-Mar-2015 | Melanie Strauss; Jacobo D. Sitt; Jean-Remi King; Maxime Elbaz; Leila Azizi; Marco Buiatti; Lionel Naccache; Virginie ..., Proceedings of the National Academy of Sciences current issue, 2015

When presented with an auditory sequence, the brain acts as a predictive-coding device that extracts regularities in the transition probabilities between sounds and detects unexpected deviations from these regularities. Does such prediction require conscious vigilance, or does it continue to ...

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Lengthening and shortening of plasma DNA in hepatocellular carcinoma patients [Medical Sciences]

17-Mar-2015 | Peiyong Jiang; Carol W. M. Chan; K. C. Allen Chan; Suk Hang Cheng; John Wong; Vincent Wai-Sun Wong; Grace L. H. Wong ..., Proceedings of the National Academy of Sciences current issue, 2015

The analysis of tumor-derived circulating cell-free DNA opens up new possibilities for performing liquid biopsies for the assessment of solid tumors. Although its clinical potential has been increasingly recognized, many aspects of the biological characteristics of tumor-derived cell-free DNA ...

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Plasmodium falciparum chloroquine resistance transporter is a H+-coupled polyspecific nutrient and drug exporter [Biochemistry]

17-Mar-2015 | Narinobu Juge; Sawako Moriyama; Takaaki Miyaji; Mamiyo Kawakami; Haruka Iwai; Tomoya Fukui; Nathan Nelson; Hiroshi O ..., Proceedings of the National Academy of Sciences current issue, 2015

Extrusion of chloroquine (CQ) from digestive vacuoles through the Plasmodium falciparum CQ resistance transporter (PfCRT) is essential to establish CQ resistance of the malaria parasite. However, the physiological relevance of PfCRT and how CQ-resistant PfCRT gains the ability to transport CQ ...

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Dynamical evidence for causality between galactic cosmic rays and interannual variation in global temperature [Earth, Atmospheric, and Planetary Sciences]

17-Mar-2015 | Anastasios A. Tsonis; Ethan R. Deyle; Robert M. May; George Sugihara; Kyle Swanson; Joshua D. Verbeten; Geli Wang, Proceedings of the National Academy of Sciences current issue, 2015

As early as 1959, it was hypothesized that an indirect link between solar activity and climate could be mediated by mechanisms controlling the flux of galactic cosmic rays (CR) [Ney ER (1959) Nature 183:451–452]. Although the connection between CR and climate remains controversial, a significant ...

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De novo production of the plant-derived alkaloid strictosidine in yeast [Biochemistry]

17-Mar-2015 | Stephanie Brown; Marc Clastre; Vincent Courdavault; Sarah E. O’Connor, Proceedings of the National Academy of Sciences current issue, 2015

The monoterpene indole alkaloids are a large group of plant-derived specialized metabolites, many of which have valuable pharmaceutical or biological activity. There are ∼3,000 monoterpene indole alkaloids produced by thousands of plant species in numerous families. The diverse chemical ...

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Origin of the HIV-1 group O epidemic in western lowland gorillas [Microbiology]

17-Mar-2015 | Mirela D’arc; Ahidjo Ayouba; Amandine Esteban; Gerald H. Learn; Vanina Boué; Florian Liegeois; Lucie Etienne; Nikki ..., Proceedings of the National Academy of Sciences current issue, 2015

HIV-1, the cause of AIDS, is composed of four phylogenetic lineages, groups M, N, O, and P, each of which resulted from an independent cross-species transmission event of simian immunodeficiency viruses (SIVs) infecting African apes. Although groups M and N have been traced to geographically ...

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Effects of large-scale deforestation on precipitation in the monsoon regions: Remote versus local effects [Earth, Atmospheric, and Planetary Sciences]

17-Mar-2015 | N. Devaraju; Govindasamy Bala; Angshuman Modak, Proceedings of the National Academy of Sciences current issue, 2015

In this paper, using idealized climate model simulations, we investigate the biogeophysical effects of large-scale deforestation on monsoon regions. We find that the remote forcing from large-scale deforestation in the northern middle and high latitudes shifts the Intertropical Convergence Zone ...

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BRUCE regulates DNA double-strand break response by promoting USP8 deubiquitination of BRIT1 [Cell Biology]

17-Mar-2015 | Chunmin Ge; Lixiao Che; Jinyu Ren; Raj K. Pandita; Jing Lu; Kaiyi Li; Tej K. Pandita; Chunying Du, Proceedings of the National Academy of Sciences current issue, 2015

The DNA damage response (DDR) is crucial for genomic integrity. BRIT1 (breast cancer susceptibility gene C terminus-repeat inhibitor of human telomerase repeat transcriptase expression), a tumor suppressor and early DDR factor, is recruited to DNA double-strand breaks (DSBs) by phosphorylated H2A ...

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Extraordinary diversity of visual opsin genes in dragonflies [Evolution]

17-Mar-2015 | Ryo Futahashi; Ryouka Kawahara-Miki; Michiyo Kinoshita; Kazutoshi Yoshitake; Shunsuke Yajima; Kentaro Arikawa; Takem ..., Proceedings of the National Academy of Sciences current issue, 2015

Dragonflies are colorful and large-eyed animals strongly dependent on color vision. Here we report an extraordinary large number of opsin genes in dragonflies and their characteristic spatiotemporal expression patterns. Exhaustive transcriptomic and genomic surveys of three dragonflies of the ...

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Rapid behavioral maturation accelerates failure of stressed honey bee colonies [Ecology]

17-Mar-2015 | Clint J. Perry; Eirik Søvik; Mary R. Myerscough; Andrew B. Barron, Proceedings of the National Academy of Sciences current issue, 2015

Many complex factors have been linked to the recent marked increase in honey bee colony failure, including pests and pathogens, agrochemicals, and nutritional stressors. It remains unclear, however, why colonies frequently react to stressors by losing almost their entire adult bee population in a ...

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