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15,600 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome [Medical Sciences]

09-Dec-2014 | Simin Lu; Kohsuke Kanekura; Takashi Hara; Jana Mahadevan; Larry D. Spears; Christine M. Oslowski; Rita Martinez; May ..., Proceedings of the National Academy of Sciences current issue, 2014

Wolfram syndrome is a genetic disorder characterized by diabetes and neurodegeneration and considered as an endoplasmic reticulum (ER) disease. Despite the underlying importance of ER dysfunction in Wolfram syndrome and the identification of two causative genes, Wolfram syndrome 1 (WFS1) and ...

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Engineering the shape and structure of materials by fractal cut [Engineering]

09-Dec-2014 | Yigil Cho; Joong-Ho Shin; Avelino Costa; Tae Ann Kim; Valentin Kunin; Ju Li; Su Yeon Lee; Shu Yang; Heung Nam Han; I ..., Proceedings of the National Academy of Sciences current issue, 2014

In this paper we discuss the transformation of a sheet of material into a wide range of desired shapes and patterns by introducing a set of simple cuts in a multilevel hierarchy with different motifs. Each choice of hierarchical cut motif and cut level allows the material to expand into...

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Museum specimens reveal loss of pollen host plants as key factor driving wild bee decline in The Netherlands [Ecology]

09-Dec-2014 | Jeroen Scheper; Menno Reemer; Ruud van Kats; Wim A. Ozinga; Giel T. J. van der Linden; Joop H. J. Schaminée; Henk Si ..., Proceedings of the National Academy of Sciences current issue, 2014

Evidence for declining populations of both wild and managed bees has raised concern about a potential global pollination crisis. Strategies to mitigate bee loss generally aim to enhance floral resources. However, we do not really know whether loss of preferred floral resources is the key driver ...

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Distinct roles of the photosystem II protein PsbS and zeaxanthin in the regulation of light harvesting in plants revealed by fluorescence lifetime snapshots [Biophysics and Computational Biology]

09-Dec-2014 | Emily J. Sylak-Glassman; Alizée Malnoë; Eleonora De Re; Matthew D. Brooks; Alexandra Lee Fischer; Krishna K. Niyogi; ..., Proceedings of the National Academy of Sciences current issue, 2014

The photosystem II (PSII) protein PsbS and the enzyme violaxanthin deepoxidase (VDE) are known to influence the dynamics of energy-dependent quenching (qE), the component of nonphotochemical quenching (NPQ) that allows plants to respond to fast fluctuations in light intensity. Although the ...

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Distinct roles of FKF1, GIGANTEA, and ZEITLUPE proteins in the regulation of CONSTANS stability in Arabidopsis photoperiodic flowering [Plant Biology]

09-Dec-2014 | Young Hun Song; Daniel A. Estrada; Richard S. Johnson; Somi K. Kim; Sang Yeol Lee; Michael J. MacCoss; Takato Imaizumi, Proceedings of the National Academy of Sciences current issue, 2014

Many plants measure changes in day length to synchronize their flowering time with appropriate seasons for maximum reproductive success. In Arabidopsis, the day-length–dependent regulation of CONSTANS (CO) protein stability is crucial to induce FLOWERING LOCUS T (FT) expression for flowering in ...

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A common brain network links development, aging, and vulnerability to disease [Neuroscience]

09-Dec-2014 | Gwenaëlle Douaud; Adrian R. Groves; Christian K. Tamnes; Lars Tjelta Westlye; Eugene P. Duff; Andreas Engvig; Kristi ..., Proceedings of the National Academy of Sciences current issue, 2014

Several theories link processes of development and aging in humans. In neuroscience, one model posits for instance that healthy age-related brain degeneration mirrors development, with the areas of the brain thought to develop later also degenerating earlier. However, intrinsic evidence for such ...

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UbcH7 regulates 53BP1 stability and DSB repair [Biochemistry]

09-Dec-2014 | Xiangzi Han; Lei Zhang; Jinsil Chung; Franklin Mayca Pozo; Amanda Tran; Darcie D. Seachrist; James W. Jacobberger; R ..., Proceedings of the National Academy of Sciences current issue, 2014

DNA double-strand break (DSB) repair is not only key to genome stability but is also an important anticancer target. Through an shRNA library-based screening, we identified ubiquitin-conjugating enzyme H7 (UbcH7, also known as Ube2L3), a ubiquitin E2 enzyme, as a critical player in DSB repair. ...

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A model for the generation and interconversion of ER morphologies [Cell Biology]

09-Dec-2014 | Tom Shemesh; Robin W. Klemm; Fabian B. Romano; Songyu Wang; Joshua Vaughan; Xiaowei Zhuang; Hanna Tukachinsky; Micha ..., Proceedings of the National Academy of Sciences current issue, 2014

The peripheral endoplasmic reticulum (ER) forms different morphologies composed of tubules and sheets. Proteins such as the reticulons shape the ER by stabilizing the high membrane curvature in cross-sections of tubules and sheet edges. Here, we show that membrane curvature along the edge lines ...

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Impact of ocean phytoplankton diversity on phosphate uptake [Environmental Sciences]

09-Dec-2014 | Michael W. Lomas; Juan A. Bonachela; Simon A. Levin; Adam C. Martiny, Proceedings of the National Academy of Sciences current issue, 2014

We have a limited understanding of the consequences of variations in microbial biodiversity on ocean ecosystem functioning and global biogeochemical cycles. A core process is macronutrient uptake by microorganisms, as the uptake of nutrients controls ocean CO2 fixation rates in many regions. ...

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Brain-machine interface for eye movements [Neuroscience]

09-Dec-2014 | Arnulf B. A. Graf; Richard A. Andersen, Proceedings of the National Academy of Sciences current issue, 2014

A number of studies in tetraplegic humans and healthy nonhuman primates (NHPs) have shown that neuronal activity from reach-related cortical areas can be used to predict reach intentions using brain–machine interfaces (BMIs) and therefore assist tetraplegic patients by controlling external ...

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