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293 Newest Publications in proceedings of the national academy of sciences current issue

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Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4 synthesis by inhibiting a calcium-activated kinase pathway [Medical Sciences]

07-10-2014 | Gabrielle Fredman; Lale Ozcan; Stefano Spolitu; Jason Hellmann; Matthew Spite; Johannes Backs; Ira Tabas, Proceedings of the National Academy of Sciences current issue, 2014

Imbalances between proinflammatory and proresolving mediators can lead to chronic inflammatory diseases. The balance of arachidonic acid-derived mediators in leukocytes is thought to be achieved through intracellular localization of 5-lipoxygenase (5-LOX): nuclear 5-LOX favors the biosynthesis of ...

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Phospholipase D2 specifically regulates TREK potassium channels via direct interaction and local production of phosphatidic acid [Neuroscience]

16-09-2014 | Yannick Comoglio; Joshua Levitz; Michael A. Kienzler; Florian Lesage; Ehud Y. Isacoff; Guillaume Sandoz, Proceedings of the National Academy of Sciences current issue, 2014

Membrane lipids serve as second messengers and docking sites for proteins and play central roles in cell signaling. A major question about lipid signaling is whether diffusible lipids can selectively target specific proteins. One family of lipid-regulated membrane proteins is the TWIK-related K ...

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Molecular mechanism of pH-dependent substrate transport by an arginine-agmatine antiporter [Biochemistry]

02-09-2014 | Sheng Wang; Renhong Yan; Xi Zhang; Qi Chu; Yigong Shi, Proceedings of the National Academy of Sciences current issue, 2014

Enteropathogenic bacteria, exemplified by Escherichia coli, rely on acid-resistance systems (ARs) to survive the acidic environment of the stomach. AR3 consumes intracellular protons through decarboxylation of arginine (Arg) in the cytoplasm and exchange of the reaction product agmatine (Agm) ...

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Robustness against serum neutralization of a poliovirus type 1 from a lethal epidemic of poliomyelitis in the Republic of Congo in 2010 [Microbiology]

02-09-2014 | Jan Felix Drexler; Gilda Grard; Alexander N. Lukashev; Liubov I. Kozlovskaya; Sindy Böttcher; Gökhan Uslu; Johan Rei ..., Proceedings of the National Academy of Sciences current issue, 2014

In 2010, a large outbreak of poliomyelitis with unusual 47% lethality occurred in Pointe Noire, Republic of Congo. Vaccine-mediated immunity against the outbreak virus was never investigated. A wild poliovirus 1 (WPV1) isolated from a fatal case (termed PV1-RC2010) showed a previously unknown ...

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Compound-gene interaction mapping reveals distinct roles for Staphylococcus aureus teichoic acids [Microbiology]

26-08-2014 | John P. Santa Maria, Jr.; Ama Sadaka; Samir H. Moussa; Stephanie Brown; Yanjia J. Zhang; Eric J. Rubin; Michael S. G ..., Proceedings of the National Academy of Sciences current issue, 2014

Staphylococcus aureus contains two distinct teichoic acid (TA) polymers, lipoteichoic acid (LTA) and wall teichoic acid (WTA), which are proposed to play redundant roles in regulating cell division. To gain insight into the underlying biology of S. aureus TAs, we used a small molecule inhibitor ...

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Synthesis and scavenging role of furan fatty acids [Microbiology]

19-08-2014 | Rachelle A. S. Lemke; Amelia C. Peterson; Eva C. Ziegelhoffer; Michael S. Westphall; Henrik Tjellström; Joshua J. Co ..., Proceedings of the National Academy of Sciences current issue, 2014

Fatty acids play important functional and protective roles in living systems. This paper reports on the synthesis of a previously unidentified 19 carbon furan-containing fatty acid, 10,13-epoxy-11-methyl-octadecadienoate (9-(3-methyl-5-pentylfuran-2-yl)nonanoic acid) (19Fu-FA), in phospholipids ...

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Spliceostatin hemiketal biosynthesis in Burkholderia spp. is catalyzed by an iron/{alpha}-ketoglutarate-dependent dioxygenase [Biochemistry]

19-08-2014 | Alessandra S. Eustáquio; Jeffrey E. Janso; Anokha S. Ratnayake; Christopher J. O’Donnell; Frank E. Koehn, Proceedings of the National Academy of Sciences current issue, 2014

Spliceostatins are potent spliceosome inhibitors biosynthesized by a hybrid nonribosomal peptide synthetase−polyketide synthase (NRPS−PKS) system of the trans-acyl transferase (AT) type. Burkholderia sp. FERM BP-3421 produces hemiketal spliceostatins, such as FR901464, as well as analogs ...

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Critical role of all-trans retinoic acid in stabilizing human natural regulatory T cells under inflammatory conditions [Immunology and Inflammation]

19-08-2014 | Ling Lu; Qin Lan; Zhiyuan Li; Xiaohui Zhou; Jian Gu; Qiang Li; Julie Wang; Maogen Chen; Ya Liu; Yi Shen; David D. Br ..., Proceedings of the National Academy of Sciences current issue, 2014

Recent studies have demonstrated that thymus-derived naturally occurring CD4+Foxp3+ regulatory T cells (Tregs) in human and mouse may be unstable and dysfunctional in the presence of proinflammatory cytokines. All-trans RA (atRA), the active derivative of vitamin A, has been shown to regulate ...

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Structural basis for the recognition-evasion arms race between Tomato mosaic virus and the resistance gene Tm-1 [Plant Biology]

19-08-2014 | Kazuhiro Ishibashi; Yuichiro Kezuka; Chihoko Kobayashi; Masahiko Kato; Tsuyoshi Inoue; Takamasa Nonaka; Masayuki Ish ..., Proceedings of the National Academy of Sciences current issue, 2014

The tomato mosaic virus (ToMV) resistance gene Tm-1 encodes a protein that shows no sequence homology to functionally characterized proteins. Tm-1 binds ToMV replication proteins and thereby inhibits replication complex formation. ToMV mutants that overcome this resistance have amino acid ...

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Toll-like receptor 9 signaling acts on multiple elements of the germinal center to enhance antibody responses [Immunology and Inflammation]

05-08-2014 | Derek C. Rookhuizen; Anthony L. DeFranco, Proceedings of the National Academy of Sciences current issue, 2014

Recent studies have demonstrated important roles of nucleic acid-sensing Toll-like receptors (TLRs) in promoting protective antibody responses against several viruses. To dissect how recognition of nucleic acids by TLRs enhances germinal center (GC) responses, mice selectively deleted for myeloid ...

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