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302 Newest Publications in proceedings of the national academy of sciences current issue

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ROR{gamma}t-specific transcriptional interactomic inhibition suppresses autoimmunity associated with TH17 cells [Immunology and Inflammation]

30-Dec-2014 | Tae-Yoon Park; Sung-Dong Park; Jen-Young Cho; Jae-Seung Moon; Na-Yeon Kim; Kyungsoo Park; Rho Hyun Seong; Sang-Won L ..., Proceedings of the National Academy of Sciences current issue, 2014

The nuclear hormone receptor retinoic acid-related orphan receptor gamma t (RORγt) is a transcription factor (TF) specific to TH17 cells that produce interleukin (IL)-17 and have been implicated in a wide range of autoimmunity. Here, we developed a novel therapeutic strategy to modulate the ...

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Detergent-free isolation, characterization, and functional reconstitution of a tetrameric K+ channel: The power of native nanodiscs [Biophysics and Computational Biology]

30-Dec-2014 | Jonas M. Dörr; Martijn C. Koorengevel; Marre Schäfer; Alexander V. Prokofyev; Stefan Scheidelaar; Elwin A. W. van de ..., Proceedings of the National Academy of Sciences current issue, 2014

A major obstacle in the study of membrane proteins is their solubilization in a stable and active conformation when using detergents. Here, we explored a detergent-free approach to isolating the tetrameric potassium channel KcsA directly from the membrane of Escherichia coli, using a ...

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Soil surface acidity plays a determining role in the atmospheric-terrestrial exchange of nitrous acid [Earth, Atmospheric, and Planetary Sciences]

30-Dec-2014 | Melissa A. Donaldson; David L. Bish; Jonathan D. Raff, Proceedings of the National Academy of Sciences current issue, 2014

Nitrous acid (HONO) is an important hydroxyl (OH) radical source that is formed on both ground and aerosol surfaces in the well-mixed boundary layer. Recent studies report the release of HONO from nonacidic soils, although it is unclear how soil that is more basic than the pKa of HONO (∼3)...

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tRNA-derived G-quadruplex protects motor neurons [Applied Biological Sciences]

23-Dec-2014 | Xiang-Lei Yang, Proceedings of the National Academy of Sciences current issue, 2014

Although not generally appreciated, the first 3D visualization of a nucleic acid was provided by the crystal structures of yeast phenylalanine transfer RNA (tRNA) (1, 2). [The DNA structure determined in the 1950s was a low-resolution fiber-diffraction–based model (3).] It was interesting to see ...

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Carlactone is converted to carlactonoic acid by MAX1 in Arabidopsis and its methyl ester can directly interact with AtD14 in vitro [Plant Biology]

16-Dec-2014 | Satoko Abe; Aika Sado; Kai Tanaka; Takaya Kisugi; Kei Asami; Saeko Ota; Hyun Il Kim; Kaori Yoneyama; Xiaonan Xie; To ..., Proceedings of the National Academy of Sciences current issue, 2014

Strigolactones (SLs) stimulate seed germination of root parasitic plants and induce hyphal branching of arbuscular mycorrhizal fungi in the rhizosphere. In addition, they have been classified as a new group of plant hormones essential for shoot branching inhibition. It has been demonstrated thus ...

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In vivo treatment of Helicobacter pylori infection with liposomal linolenic acid reduces colonization and ameliorates inflammation [Engineering]

09-Dec-2014 | Soracha Thamphiwatana; Weiwei Gao; Marygorret Obonyo; Liangfang Zhang, Proceedings of the National Academy of Sciences current issue, 2014

Helicobacter pylori infection is marked by a vast prevalence and strong association with various gastric diseases, including gastritis, peptic ulcers, and gastric cancer. Because of the rapid emergence of H. pylori strains resistant to existing antibiotics, current treatment regimens show a rapid ...

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Amino acid modified Ni catalyst exhibits reversible H2 oxidation/production over a broad pH range at elevated temperatures [Chemistry]

18-Nov-2014 | Arnab Dutta; Daniel L. DuBois; John A. S. Roberts; Wendy J. Shaw, Proceedings of the National Academy of Sciences current issue, 2014

Hydrogenases interconvert H2 and protons at high rates and with high energy efficiencies, providing inspiration for the development of molecular catalysts. Studies designed to determine how the protein scaffold can influence a catalytically active site have led to the synthesis of amino acid ...

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Genetic activation of pyruvate dehydrogenase alters oxidative substrate selection to induce skeletal muscle insulin resistance [Medical Sciences]

18-Nov-2014 | Yasmeen Rahimi; João-Paulo G. Camporez; Max C. Petersen; Dominik Pesta; Rachel J. Perry; Michael J. Jurczak; Gary W. ..., Proceedings of the National Academy of Sciences current issue, 2014

The pyruvate dehydrogenase complex (PDH) has been hypothesized to link lipid exposure to skeletal muscle insulin resistance through a glucose-fatty acid cycle in which increased fatty acid oxidation increases acetyl-CoA concentrations, thereby inactivating PDH and decreasing glucose oxidation. ...

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Use of protein cross-linking and radiolytic footprinting to elucidate PsbP and PsbQ interactions within higher plant Photosystem II [Plant Biology]

11-Nov-2014 | Manjula P. Mummadisetti; Laurie K. Frankel; Henry D. Bellamy; Larry Sallans; Jost S. Goettert; Michal Brylinski; Pat ..., Proceedings of the National Academy of Sciences current issue, 2014

Protein cross-linking and radiolytic footprinting coupled with high-resolution mass spectrometry were used to examine the structure of PsbP and PsbQ when they are bound to Photosystem II. In its bound state, the N-terminal 15-amino-acid residue domain of PsbP, which is unresolved in current ...

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Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4 synthesis by inhibiting a calcium-activated kinase pathway [Medical Sciences]

07-Oct-2014 | Gabrielle Fredman; Lale Ozcan; Stefano Spolitu; Jason Hellmann; Matthew Spite; Johannes Backs; Ira Tabas, Proceedings of the National Academy of Sciences current issue, 2014

Imbalances between proinflammatory and proresolving mediators can lead to chronic inflammatory diseases. The balance of arachidonic acid-derived mediators in leukocytes is thought to be achieved through intracellular localization of 5-lipoxygenase (5-LOX): nuclear 5-LOX favors the biosynthesis of ...

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