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278 Newest Publications in proceedings of the national academy of sciences current issue

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Salicylic acid 3-hydroxylase regulates Arabidopsis leaf longevity by mediating salicylic acid catabolism [Plant Biology]

03-09-2013 | Kewei Zhang; Rayko Halitschke; Changxi Yin; Chang-Jun Liu; Su-Sheng Gan, Proceedings of the National Academy of Sciences current issue, 2013

The plant hormone salicylic acid (SA) plays critical roles in plant defense, stress responses, and senescence. Although SA biosynthesis is well understood, the pathways by which SA is catabolized remain elusive. Here we report the identification and characterization of an SA 3-hydroxylase (S3H) ...

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Efficient influenza A virus replication in the respiratory tract requires signals from TLR7 and RIG-I [Immunology]

20-08-2013 | Iris K. Pang; Padmini S. Pillai; Akiko Iwasaki, Proceedings of the National Academy of Sciences current issue, 2013

Induction of a proinflammatory response is the hallmark of host innate defense against invading pathogens. Host recognition of influenza A virus (IAV) infection relies on pattern-recognition receptors, including Toll-like receptor 7 (TLR7) and retinoic acid inducible gene-1 (RIG-I) for the ...

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Unexpectedly high indoor hydroxyl radical concentrations associated with nitrous acid [Environmental Sciences]

13-08-2013 | Elena Gómez Alvarez; Damien Amedro; Charbel Afif; Sasho Gligorovski; Coralie Schoemacker; Christa Fittschen; Jean-Fr ..., Proceedings of the National Academy of Sciences current issue, 2013

The hydroxyl (OH) radical is the most important oxidant in the atmosphere since it controls its self-oxidizing capacity. The main sources of OH radicals are the photolysis of ozone and the photolysis of nitrous acid (HONO). Due to the attenuation of solar radiation in the indoor environment, the ...

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In This Issue [This Week in PNAS]

13-08-2013 | Proceedings of the National Academy of Sciences current issue, 2013

Formation of hydroxyl radical in indoor air High levels of hydroxyl radicals (OH) indoors were associated with light-induced breakdown of nitrous acid. Image courtesy of Vladimir Gligorovski (Ecole Nationale Supérieure d’Architecture de Marseille). The hydroxyl (OH) radical is a highly reactive ...

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Experimental and computational analysis of the transition state for ribonuclease A-catalyzed RNA 2'-O-transphosphorylation [Biophysics and Computational Biology]

06-08-2013 | Hong Gu; Shuming Zhang; Kin-Yiu Wong; Brian K. Radak; Thakshila Dissanayake; Daniel L. Kellerman; Qing Dai; Masaru M ..., Proceedings of the National Academy of Sciences current issue, 2013

Enzymes function by stabilizing reaction transition states; therefore, comparison of the transition states of enzymatic and nonenzymatic model reactions can provide insight into biological catalysis. Catalysis of RNA 2′-O-transphosphorylation by ribonuclease A is proposed to involve electrostatic ...

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Structural insights into the regulation of sialic acid catabolism by the Vibrio vulnificus transcriptional repressor NanR [Microbiology]

23-07-2013 | Jungwon Hwang; Byoung Sik Kim; Song Yee Jang; Jong Gyu Lim; Dong-Ju You; Hyun Suk Jung; Tae-Kwang Oh; Jie-Oh Lee; Sa ..., Proceedings of the National Academy of Sciences current issue, 2013

Pathogenic and commensal bacteria that experience limited nutrient availability in their host have evolved sophisticated systems to catabolize the mucin sugar N-acetylneuraminic acid, thereby facilitating their survival and colonization. The correct function of the associated catabolic machinery ...

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Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32 [Microbiology]

09-07-2013 | Sarah A. Stanley; Tomohiko Kawate; Noriaki Iwase; Motohisa Shimizu; Anne E. Clatworthy; Edward Kazyanskaya; James C. ..., Proceedings of the National Academy of Sciences current issue, 2013

Infection with the bacterial pathogen Mycobacterium tuberculosis imposes an enormous burden on global public health. New antibiotics are urgently needed to combat the global tuberculosis pandemic; however, the development of new small molecules is hindered by a lack of validated drug targets. ...

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General approach to reversing ketol-acid reductoisomerase cofactor dependence from NADPH to NADH [Biochemistry]

02-07-2013 | Sabine Brinkmann-Chen; Tilman Flock; Jackson K. B. Cahn; Christopher D. Snow; Eric M. Brustad; John A. McIntosh; Pet ..., Proceedings of the National Academy of Sciences current issue, 2013

To date, efforts to switch the cofactor specificity of oxidoreductases from nicotinamide adenine dinucleotide phosphate (NADPH) to nicotinamide adenine dinucleotide (NADH) have been made on a case-by-case basis with varying degrees of success. Here we present a straightforward recipe for altering ...

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Quantitative phosphoproteomics identifies SnRK2 protein kinase substrates and reveals the effectors of abscisic acid action [Plant Biology]

02-07-2013 | Pengcheng Wang; Liang Xue; Giorgia Batelli; Shinyoung Lee; Yueh-Ju Hou; Michael J. Van Oosten; Huiming Zhang; W. And ..., Proceedings of the National Academy of Sciences current issue, 2013

Sucrose nonfermenting 1 (SNF1)-related protein kinase 2s (SnRK2s) are central components of abscisic acid (ABA) signaling pathways. The snrk2.2/2.3/2.6 triple-mutant plants are nearly completely insensitive to ABA, suggesting that most of the molecular actions of ABA are triggered by the ...

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Early human diets [Inner Workings]

25-06-2013 | Charles Choi, Proceedings of the National Academy of Sciences current issue, 2013

Thure Cerling in his laboratory. Image courtesy of Lee Siegel, University of Utah. Gases liberated from microscopic fragments of teeth dissolved in acid flow down networks of blown-glass tubes in geochemist Thure Cerling’s laboratory at the University of Utah. From these gases, Cerling and his ...

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