My watch list
my.chemeurope.com  
Login  

562 Newest Publications in proceedings of the national academy of sciences current issue

rss
matching the following criteria

Cleavage and polyadenylation specificity factor 30: An RNA-binding zinc-finger protein with an unexpected 2Fe-2S cluster [Chemistry]

26-Apr-2016 | Geoffrey D. Shimberg; Jamie L. Michalek; Abdulafeez A. Oluyadi; Andria V. Rodrigues; Beth E. Zucconi; Heather M. Neu ..., Proceedings of the National Academy of Sciences current issue, 2016

Cleavage and polyadenylation specificity factor 30 (CPSF30) is a key protein involved in pre-mRNA processing. CPSF30 contains five Cys3His domains (annotated as “zinc-finger” domains). Using inductively coupled plasma mass spectrometry, X-ray absorption spectroscopy, and UV-visible spectroscopy, ...

more

Exploring the surfaceome of Ewing sarcoma identifies a new and unique therapeutic target [Medical Sciences]

29-Mar-2016 | Jennifer Town; Helio Pais; Sally Harrison; Lucy F. Stead; Carole Bataille; Wilawan Bunjobpol; Jing Zhang; Terence H. ..., Proceedings of the National Academy of Sciences current issue, 2016

The cell surface proteome of tumors mediates the interface between the transformed cells and the general microenvironment, including interactions with stromal cells in the tumor niche and immune cells such as T cells. In addition, the cell surface proteome of individual cancers defines biomarkers ...

more

Truncated mu opioid GPCR variant involvement in opioid-dependent and opioid-independent pain modulatory systems within the CNS [Pharmacology]

29-Mar-2016 | Gina F. Marrone; Steven G. Grinnell; Zhigang Lu; Grace C. Rossi; Valerie Le Rouzic; Jin Xu; Susruta Majumdar; Ying-X ..., Proceedings of the National Academy of Sciences current issue, 2016

The clinical management of severe pain depends heavily on opioids acting through mu opioid receptors encoded by the Oprm1 gene, which undergoes extensive alternative splicing. In addition to generating a series of prototypic seven transmembrane domain (7TM) G protein-coupled receptors (GPCRs), ...

more

Open complex scrunching before nucleotide addition accounts for the unusual transcription start site of E. coli ribosomal RNA promoters [Biochemistry]

29-Mar-2016 | Jared T. Winkelman; Pete Chandrangsu; Wilma Ross; Richard L. Gourse, Proceedings of the National Academy of Sciences current issue, 2016

Most Escherichia coli promoters initiate transcription with a purine 7 or 8 nt downstream from the –10 hexamer, but some promoters, including the ribosomal RNA promoter rrnB P1, start 9 nt from the –10 element. We identified promoter and RNA polymerase determinants of this noncanonical rrnB P1 ...

more

Marine microplastics spell big problems for future generations [Environmental Sciences]

01-Mar-2016 | Tamara S. Galloway; Ceri N. Lewis, Proceedings of the National Academy of Sciences current issue, 2016

There are certain human environmental perturbations so major that they are capable of destabilizing the earth’s normal function at a global scale (1). These so-called planetary boundary threats include climate change, ozone depletion, and ocean acidification. Emerging as a novel addition to this ...

more

Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGAS [Microbiology]

23-Feb-2016 | Guigen Zhang; Baca Chan; Naira Samarina; Bizunesh Abere; Magdalena Weidner-Glunde; Anna Buch; Andreas Pich; Melanie ..., Proceedings of the National Academy of Sciences current issue, 2016

The latency-associated nuclear antigen (LANA) of Kaposi sarcoma herpesvirus (KSHV) is mainly localized and functions in the nucleus of latently infected cells, playing a pivotal role in the replication and maintenance of latent viral episomal DNA. In addition, N-terminally truncated cytoplasmic ...

more

In This Issue [This Week in PNAS]

16-Feb-2016 | Proceedings of the National Academy of Sciences current issue, 2016

Enhanced efficacy of adjuvanted influenza vaccine in children 3D graphic of generic influenza virion ultrastructure. Image courtesy of Dan Higgins/CDC. Clinical trials have revealed that the efficacy of the seasonal trivalent inactivated influenza vaccine (TIV) in 6- to 72-month-old children is ...

more

On the universal structure of human lexical semantics [Psychological and Cognitive Sciences]

16-Feb-2016 | Hyejin Youn; Logan Sutton; Eric Smith; Cristopher Moore; Jon F. Wilkins; Ian Maddieson; William Croft; Tanmoy Bhatta ..., Proceedings of the National Academy of Sciences current issue, 2016

How universal is human conceptual structure? The way concepts are organized in the human brain may reflect distinct features of cultural, historical, and environmental background in addition to properties universal to human cognition. Semantics, or meaning expressed through language, provides ...

more

Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I [Biochemistry]

19-Jan-2016 | Swapnil C. Devarkar; Chen Wang; Matthew T. Miller; Anand Ramanathan; Fuguo Jiang; Abdul G. Khan; Smita S. Patel; Jos ..., Proceedings of the National Academy of Sciences current issue, 2016

RNAs with 5′-triphosphate (ppp) are detected in the cytoplasm principally by the innate immune receptor Retinoic Acid Inducible Gene-I (RIG-I), whose activation triggers a Type I IFN response. It is thought that self RNAs like mRNAs are not recognized by RIG-I because 5′ppp is capped by the ...

more

Reply to Davis: Nitric oxide regulates lymphatic contractions [Biological Sciences]

12-Jan-2016 | Christian Kunert; James W. Baish; Shan Liao; Timothy P. Padera; Lance L. Munn, Proceedings of the National Academy of Sciences current issue, 2016

We appreciate the opportunity to respond to Michael J. Davis’s Letter (1) regarding our paper “Mechanobiological Oscillators Control Lymph Flow” (2). Our model was developed to study phasic contractions and the dynamics of NO and calcium rather than the control of basal tone. Many factors—in ...

more

Page 1 From 57
Subscribe to e-mail updates relating to your search

You will receive via e-mail the latest search results matching your search criteria. This service is free of charge and can be cancelled at any time.

Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE