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524 Newest Publications in proceedings of the national academy of sciences current issue

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PTEN signaling through RAF1 proto-oncogene serine/threonine kinase (RAF1)/ERK in the epididymis is essential for male fertility [Developmental Biology]

30-Dec-2014 | Bingfang Xu; Angela M. Washington; Barry T. Hinton, Proceedings of the National Academy of Sciences current issue, 2014

Without a fully developed initial segment, the most proximal region of the epididymis, male infertility results. Therefore, it is important to understand the development and regulation of this crucial region. In addition to distinctively high activity levels of the components of the ERK pathway, ...

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Structural basis of HIV-1 capsid recognition by PF74 and CPSF6 [Biophysics and Computational Biology]

30-Dec-2014 | Akash Bhattacharya; Steven L. Alam; Thomas Fricke; Kaneil Zadrozny; Jaroslaw Sedzicki; Alexander B. Taylor; Borries ..., Proceedings of the National Academy of Sciences current issue, 2014

Upon infection of susceptible cells by HIV-1, the conical capsid formed by ∼250 hexamers and 12 pentamers of the CA protein is delivered to the cytoplasm. The capsid shields the RNA genome and proteins required for reverse transcription. In addition, the surface of the capsid mediates numerous ...

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Carlactone is converted to carlactonoic acid by MAX1 in Arabidopsis and its methyl ester can directly interact with AtD14 in vitro [Plant Biology]

16-Dec-2014 | Satoko Abe; Aika Sado; Kai Tanaka; Takaya Kisugi; Kei Asami; Saeko Ota; Hyun Il Kim; Kaori Yoneyama; Xiaonan Xie; To ..., Proceedings of the National Academy of Sciences current issue, 2014

Strigolactones (SLs) stimulate seed germination of root parasitic plants and induce hyphal branching of arbuscular mycorrhizal fungi in the rhizosphere. In addition, they have been classified as a new group of plant hormones essential for shoot branching inhibition. It has been demonstrated thus ...

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Activity-regulating structural changes and autoantibody epitopes in transglutaminase 2 assessed by hydrogen/deuterium exchange [Biochemistry]

02-Dec-2014 | Rasmus Iversen; Simon Mysling; Kathrin Hnida; Thomas J. D. Jørgensen; Ludvig M. Sollid, Proceedings of the National Academy of Sciences current issue, 2014

The multifunctional enzyme transglutaminase 2 (TG2) is the target of autoantibodies in the gluten-sensitive enteropathy celiac disease. In addition, the enzyme is responsible for deamidation of gluten peptides, which are subsequently targeted by T cells. To understand the regulation of TG2 ...

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XerD-mediated FtsK-independent integration of TLC{phi} into the Vibrio cholerae genome [Microbiology]

25-Nov-2014 | Caroline Midonet; Bhabatosh Das; Evelyne Paly; Francois-Xavier Barre, Proceedings of the National Academy of Sciences current issue, 2014

As in most bacteria, topological problems arising from the circularity of the two Vibrio cholerae chromosomes, chrI and chrII, are resolved by the addition of a crossover at a specific site of each chromosome, dif, by two tyrosine recombinases, XerC and XerD. The reaction is under the control of ...

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Reply to Metson et al.: The importance of phosphorus perturbations [Physical Sciences]

18-Nov-2014 | Gidon Eshel; Alon Shepon; Tamar Makov; Ron Milo, Proceedings of the National Academy of Sciences current issue, 2014

We thank Metson et al. (1) for their addition to our paper (2). These authors raise an important point, and are definitely right in pointing out the global importance of phosphorous and the dominant role of the livestock industry in its use. Our omission of phosphorous from our calculations, ...

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Interplay of Mg2+, ADP, and ATP in the cytosol and mitochondria: Unravelling the role of Mg2+ in cell respiration [Biochemistry]

28-Oct-2014 | Elisabeth Gout; Fabrice Rébeillé; Roland Douce; Richard Bligny, Proceedings of the National Academy of Sciences current issue, 2014

In animal and plant cells, the ATP/ADP ratio and/or energy charge are generally considered key parameters regulating metabolism and respiration. The major alternative issue of whether the cytosolic and mitochondrial concentrations of ADP and ATP directly mediate cell respiration remains unclear, ...

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Role of Erbin in ErbB2-dependent breast tumor growth [Cell Biology]

21-Oct-2014 | Yanmei Tao; Chengyong Shen; Shiwen Luo; Wilfried Traoré; Sylvie Marchetto; Marie-Josée Santoni; Linlin Xu; Biao Wu; ..., Proceedings of the National Academy of Sciences current issue, 2014

ErbB2 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2), a receptor tyrosine kinase of the ErbB family, is overexpressed in around 25% of breast cancers. In addition to forming a heterodimer with other ErbB receptors in response to ligand stimulation, ErbB2 can be activated in a ...

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Tracking sustainable development with a national barometer for South Africa using a downscaled "safe and ȷust space" framework [Sustainability Science]

21-Oct-2014 | Megan J. Cole; Richard M. Bailey; Mark G. New, Proceedings of the National Academy of Sciences current issue, 2014

Nations in the 21st century face a complex mix of environmental and social challenges, as highlighted by the on-going Sustainable Development Goals process. The “planetary boundaries” concept [Rockström J, et al. (2009) Nature 461(7263):472–475], and its extension through the addition of social ...

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Insulin and insulin-like growth factor 1 receptors are required for normal expression of imprinted genes [Medical Sciences]

07-Oct-2014 | Jeremie Boucher; Marika Charalambous; Kim Zarse; Marcelo A. Mori; Andre Kleinridders; Michael Ristow; Anne C. Fergus ..., Proceedings of the National Academy of Sciences current issue, 2014

In addition to signaling through the classical tyrosine kinase pathway, recent studies indicate that insulin receptors (IRs) and insulin-like growth factor 1 (IGF1) receptors (IGF1Rs) can emit signals in the unoccupied state through some yet-to-be-defined noncanonical pathways. Here we show that ...

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