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519 Newest Publications in proceedings of the national academy of sciences current issue

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Reply to Metson et al.: The importance of phosphorus perturbations [Physical Sciences]

18-11-2014 | Gidon Eshel; Alon Shepon; Tamar Makov; Ron Milo, Proceedings of the National Academy of Sciences current issue, 2014

We thank Metson et al. (1) for their addition to our paper (2). These authors raise an important point, and are definitely right in pointing out the global importance of phosphorous and the dominant role of the livestock industry in its use. Our omission of phosphorous from our calculations, ...

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Interplay of Mg2+, ADP, and ATP in the cytosol and mitochondria: Unravelling the role of Mg2+ in cell respiration [Biochemistry]

28-10-2014 | Elisabeth Gout; Fabrice Rébeillé; Roland Douce; Richard Bligny, Proceedings of the National Academy of Sciences current issue, 2014

In animal and plant cells, the ATP/ADP ratio and/or energy charge are generally considered key parameters regulating metabolism and respiration. The major alternative issue of whether the cytosolic and mitochondrial concentrations of ADP and ATP directly mediate cell respiration remains unclear, ...

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Role of Erbin in ErbB2-dependent breast tumor growth [Cell Biology]

21-10-2014 | Yanmei Tao; Chengyong Shen; Shiwen Luo; Wilfried Traoré; Sylvie Marchetto; Marie-Josée Santoni; Linlin Xu; Biao Wu; ..., Proceedings of the National Academy of Sciences current issue, 2014

ErbB2 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2), a receptor tyrosine kinase of the ErbB family, is overexpressed in around 25% of breast cancers. In addition to forming a heterodimer with other ErbB receptors in response to ligand stimulation, ErbB2 can be activated in a ...

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Tracking sustainable development with a national barometer for South Africa using a downscaled "safe and ȷust space" framework [Sustainability Science]

21-10-2014 | Megan J. Cole; Richard M. Bailey; Mark G. New, Proceedings of the National Academy of Sciences current issue, 2014

Nations in the 21st century face a complex mix of environmental and social challenges, as highlighted by the on-going Sustainable Development Goals process. The “planetary boundaries” concept [Rockström J, et al. (2009) Nature 461(7263):472–475], and its extension through the addition of social ...

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Insulin and insulin-like growth factor 1 receptors are required for normal expression of imprinted genes [Medical Sciences]

07-10-2014 | Jeremie Boucher; Marika Charalambous; Kim Zarse; Marcelo A. Mori; Andre Kleinridders; Michael Ristow; Anne C. Fergus ..., Proceedings of the National Academy of Sciences current issue, 2014

In addition to signaling through the classical tyrosine kinase pathway, recent studies indicate that insulin receptors (IRs) and insulin-like growth factor 1 (IGF1) receptors (IGF1Rs) can emit signals in the unoccupied state through some yet-to-be-defined noncanonical pathways. Here we show that ...

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Atmospheric controls on northeast Pacific temperature variability and change, 1900-2012 [Earth, Atmospheric, and Planetary Sciences]

07-10-2014 | James A. Johnstone; Nathan J. Mantua, Proceedings of the National Academy of Sciences current issue, 2014

Over the last century, northeast Pacific coastal sea surface temperatures (SSTs) and land-based surface air temperatures (SATs) display multidecadal variations associated with the Pacific Decadal Oscillation, in addition to a warming trend of ∼0.5–1 °C. Using independent records of sea-level ...

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One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities [Microbiology]

16-09-2014 | Lorenzo Subissi; Clara C. Posthuma; Axelle Collet; Jessika C. Zevenhoven-Dobbe; Alexander E. Gorbalenya; Etienne Dec ..., Proceedings of the National Academy of Sciences current issue, 2014

In addition to members causing milder human infections, the Coronaviridae family includes potentially lethal zoonotic agents causing severe acute respiratory syndrome (SARS) and the recently emerged Middle East respiratory syndrome. The ∼30-kb positive-stranded RNA genome of coronaviruses encodes ...

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Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1{alpha} to promote cell-cycle progression [Medical Sciences]

12-08-2014 | Maimon E. Hubbi; Daniele M. Gilkes; Hongxia Hu; Kshitiz; Ishrat Ahmed; Gregg L. Semenza, Proceedings of the National Academy of Sciences current issue, 2014

Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that mediates adaptive responses to oxygen deprivation. In addition, the HIF-1α subunit has a nontranscriptional role as a negative regulator of DNA replication through effects on minichromosome maintenance helicase loading and ...

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Subpolar addition of new cell wall is directed by DivIVA in mycobacteria [Microbiology]

05-08-2014 | Xavier Meniche; Renee Otten; M. Sloan Siegrist; Christina E. Baer; Kenan C. Murphy; Carolyn R. Bertozzi; Christopher ..., Proceedings of the National Academy of Sciences current issue, 2014

Mycobacteria are surrounded by a complex multilayered envelope and elongate at the poles. The principles that organize the coordinated addition of chemically diverse cell wall layers during polar extension remain unclear. We show that enzymes mediating the terminal cytosolic steps of ...

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Secondary bacterial flagellar system improves bacterial spreading by increasing the directional persistence of swimming [Environmental Sciences]

05-08-2014 | Sebastian Bubendorfer; Mihaly Koltai; Florian Rossmann; Victor Sourjik; Kai M. Thormann, Proceedings of the National Academy of Sciences current issue, 2014

As numerous bacterial species, Shewanella putrefaciens CN-32 possesses a complete secondary flagellar system. A significant subpopulation of CN-32 cells induces expression of the secondary system under planktonic conditions, resulting in formation of one, sometimes two, filaments at lateral ...

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