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509 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

Money and trust among strangers [Economic Sciences]

10-09-2013 | Gabriele Camera; Marco Casari; Maria Bigoni, Proceedings of the National Academy of Sciences current issue, 2013

What makes money essential for the functioning of modern society? Through an experiment, we present evidence for the existence of a relevant behavioral dimension in addition to the standard theoretical arguments. Subjects faced repeated opportunities to help an anonymous counterpart who changed ...

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R-spondin3 prevents mesenteric ischemia/reperfusion-induced tissue damage by tightening endothelium and preventing vascular leakage [Immunology]

27-08-2013 | Lakshmi Kannan; Katalin Kis-Toth; Kazuhisa Yoshiya; To-Ha Thai; Seema Sehrawat; Tanya N. Mayadas; Jurandir J. Dalle ..., Proceedings of the National Academy of Sciences current issue, 2013

Inflammation and vascular injury triggered by ischemia/reperfusion (I/R) represent a leading cause of morbidity and mortality in a number of clinical settings. Wnt and its homolog partners R-spondins, in addition to regulating embryonic development have recently been demonstrated to serve as ...

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Brain-computer interfaces increase whole-brain signal to noise [Neuroscience]

13-08-2013 | T. Dorina Papageorgiou; Jonathan M. Lisinski; Monica A. McHenry; Jason P. White; Stephen M. LaConte, Proceedings of the National Academy of Sciences current issue, 2013

Brain–computer interfaces (BCIs) can convert mental states into signals to drive real-world devices, but it is not known if a given covert task is the same when performed with and without BCI-based control. Using a BCI likely involves additional cognitive processes, such as multitasking, ...

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MIF intersubunit disulfide mutant antagonist supports activation of CD74 by endogenous MIF trimer at physiologic concentrations [Biophysics and Computational Biology]

02-07-2013 | Chengpeng Fan; Deepa Rajasekaran; Mansoor Ali Syed; Lin Leng; J. Patrick Loria; Vineet Bhandari; Richard Bucala; Eli ..., Proceedings of the National Academy of Sciences current issue, 2013

Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine. In addition to its known receptor-mediated biological activities, MIF possesses a catalytic site of unknown function between subunits of a homotrimer. Each subunit contributes three β-strands to adjacent subunits to form ...

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Identification of a small molecule with activity against drug-resistant and persistent tuberculosis [Microbiology]

02-07-2013 | Feng Wang; Dhinakaran Sambandan; Rajkumar Halder; Jianing Wang; Sarah M. Batt; Brian Weinrick; Insha Ahmad; Pengyu Y ..., Proceedings of the National Academy of Sciences current issue, 2013

A cell-based phenotypic screen for inhibitors of biofilm formation in mycobacteria identified the small molecule TCA1, which has bactericidal activity against both drug-susceptible and -resistant Mycobacterium tuberculosis (Mtb) and sterilizes Mtb in vitro combined with rifampicin or isoniazid. ...

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Conserved microRNA pathway regulates developmental timing of retinal neurogenesis [Developmental Biology]

25-06-2013 | Anna La Torre; Sean Georgi; Thomas A. Reh, Proceedings of the National Academy of Sciences current issue, 2013

Most regions of the vertebrate central nervous system develop by the sequential addition of different classes of neurons and glia. This phenomenon has been best characterized in laminated structures like the retina and the cerebral cortex, in which the progenitor cells in these structures are ...

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The cost of efficiency in energy metabolism [Systems Biology]

11-06-2013 | Arion I. Stettner; Daniel Segrè, Proceedings of the National Academy of Sciences current issue, 2013

In a universe being dragged into disorder by the second law of thermodynamics, living cells must expend energy to maintain their complex organization. In addition to providing a carbon source for biosynthesis, the classical Embden–Meyerhof–Parnas (EMP) and Entner-Doudoroff (ED) pathways help to ...

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Regulation of T cell function by the ubiquitin-specific protease USP9X via modulating the Carma1-Bcl10-Malt1 complex [Immunology]

04-06-2013 | Yoon Park; Hyung-seung Jin; Yun-Cai Liu, Proceedings of the National Academy of Sciences current issue, 2013

The ubiquitin conjugation system plays an important role in immune regulation; however, the ubiquitin-specific proteases (USPs) that carry out deubiquitination of cellular substrates are poorly understood. Here we show that in vivo knockdown of the deubiquitinating enzyme USP9X attenuates T-cell ...

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Retargeting of the Bacillus thuringiensis toxin Cyt2Aa against hemipteran insect pests [Agricultural Sciences]

21-05-2013 | Nanasaheb P. Chougule; Huarong Li; Sijun Liu; Lucas B. Linz; Kenneth E. Narva; Thomas Meade; Bryony C. Bonning, Proceedings of the National Academy of Sciences current issue, 2013

Although transgenic crops expressing Bacillus thuringiensis (Bt) toxins have been used successfully for management of lepidopteran and coleopteran pest species, the sap-sucking insects (Hemiptera) are not particularly susceptible to Bt toxins. To overcome this limitation, we demonstrate that ...

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Dnmt2-dependent methylomes lack defined DNA methylation patterns [Genetics]

21-05-2013 | Günter Raddatz; Paloma M. Guzzardo; Nelly Olova; Marcelo Rosado Fantappié; Markus Rampp; Matthias Schaefer; Wolf Rei ..., Proceedings of the National Academy of Sciences current issue, 2013

Several organisms have retained methyltransferase 2 (Dnmt2) as their only candidate DNA methyltransferase gene. However, information about Dnmt2-dependent methylation patterns has been limited to a few isolated loci and the results have been discussed controversially. In addition, recent studies ...

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