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554 Newest Publications in proceedings of the national academy of sciences current issue

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Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I [Biochemistry]

19-Jan-2016 | Swapnil C. Devarkar; Chen Wang; Matthew T. Miller; Anand Ramanathan; Fuguo Jiang; Abdul G. Khan; Smita S. Patel; Jos ..., Proceedings of the National Academy of Sciences current issue, 2016

RNAs with 5′-triphosphate (ppp) are detected in the cytoplasm principally by the innate immune receptor Retinoic Acid Inducible Gene-I (RIG-I), whose activation triggers a Type I IFN response. It is thought that self RNAs like mRNAs are not recognized by RIG-I because 5′ppp is capped by the ...

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Reply to Davis: Nitric oxide regulates lymphatic contractions [Biological Sciences]

12-Jan-2016 | Christian Kunert; James W. Baish; Shan Liao; Timothy P. Padera; Lance L. Munn, Proceedings of the National Academy of Sciences current issue, 2016

We appreciate the opportunity to respond to Michael J. Davis’s Letter (1) regarding our paper “Mechanobiological Oscillators Control Lymph Flow” (2). Our model was developed to study phasic contractions and the dynamics of NO and calcium rather than the control of basal tone. Many factors—in ...

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Hepatitis C virus utilizes VLDLR as a novel entry pathway [Microbiology]

05-Jan-2016 | Saneyuki Ujino; Hironori Nishitsuji; Takayuki Hishiki; Kazuo Sugiyama; Hiroshi Takaku; Kunitada Shimotohno, Proceedings of the National Academy of Sciences current issue, 2016

Various host factors are involved in the cellular entry of hepatitis C virus (HCV). In addition to the factors previously reported, we discovered that the very-low-density lipoprotein receptor (VLDLR) mediates HCV entry independent of CD81. Culturing Huh7.5 cells under hypoxic conditions ...

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Energetics and population genetics at the root of eukaryotic cellular and genomic complexity [Evolution]

29-Dec-2015 | Eugene V. Koonin, Proceedings of the National Academy of Sciences current issue, 2015

In PNAS, Lynch and Marinov provide detailed estimates of the energy cost associated with the addition of new coding or noncoding sequences to prokaryotic and eukaryotic genomes (1). The amount of ATP that is expended at each step of information transfer is derived from the known biochemistry of ...

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ClpB N-terminal domain plays a regulatory role in protein disaggregation [Biophysics and Computational Biology]

15-Dec-2015 | Rina Rosenzweig; Patrick Farber; Algirdas Velyvis; Enrico Rennella; Michael P. Latham; Lewis E. Kay, Proceedings of the National Academy of Sciences current issue, 2015

ClpB/Hsp100 is an ATP-dependent disaggregase that solubilizes and reactivates protein aggregates in cooperation with the DnaK/Hsp70 chaperone system. The ClpB–substrate interaction is mediated by conserved tyrosine residues located in flexible loops in nucleotide-binding domain-1 that extend into ...

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Uterine glucocorticoid receptors are critical for fertility in mice through control of embryo implantation and decidualization [Medical Sciences]

08-Dec-2015 | Shannon D. Whirledge; Robert H. Oakley; Page H. Myers; John P. Lydon; Francesco DeMayo; John A. Cidlowski, Proceedings of the National Academy of Sciences current issue, 2015

In addition to the well-characterized role of the sex steroid receptors in fertility and reproduction, organs of the female reproductive tract are also regulated by the hypothalamic–pituitary–adrenal axis. These endocrine organs are sensitive to stress-mediated actions of glucocorticoids, and the ...

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Poly(ADP-ribose) polymerase 1 is a novel target to promote axonal regeneration [Neuroscience]

08-Dec-2015 | Camille Brochier; James I. Jones; Dianna E. Willis; Brett Langley, Proceedings of the National Academy of Sciences current issue, 2015

Therapeutic options for the restoration of neurological functions after acute axonal injury are severely limited. In addition to limiting neuronal loss, effective treatments face the challenge of restoring axonal growth within an injury environment where inhibitory molecules from damaged myelin ...

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Accurate estimation of influenza epidemics using Google search data via ARGO [Applied Mathematics]

24-Nov-2015 | Shihao Yang; Mauricio Santillana; S. C. Kou, Proceedings of the National Academy of Sciences current issue, 2015

Accurate real-time tracking of influenza outbreaks helps public health officials make timely and meaningful decisions that could save lives. We propose an influenza tracking model, ARGO (AutoRegression with GOogle search data), that uses publicly available online search data. In addition to ...

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Reply to Purcell et al.: Fishers and science agree, rotational harvesting reduces risk and promotes efficiency [Biological Sciences]

17-Nov-2015 | Éva Elizabeth Plagányi; Timothy Skewes; Malcolm Haddon; Nicole Murphy; Ricardo Pascual; Mibu Fischer, Proceedings of the National Academy of Sciences current issue, 2015

Plagányi et al. (1) show that a rotational zone strategy (RZS) applied to sea cucumbers in a multispecies fishery on Australia’s Great Barrier Reef significantly reduces the risk of overall and localized species depletion in the fishery. In addition to implementing limits on catch and minimum ...

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Regulation of calreticulin-maȷor histocompatibility complex (MHC) class I interactions by ATP [Immunology and Inflammation]

13-Oct-2015 | Sanjeeva Joseph Wijeyesakere; Jessica K. Gagnon; Karunesh Arora; Charles L. Brooks III; Malini Raghavan, Proceedings of the National Academy of Sciences current issue, 2015

The MHC class I peptide loading complex (PLC) facilitates the assembly of MHC class I molecules with peptides, but factors that regulate the stability and dynamics of the assembly complex are largely uncharacterized. Based on initial findings that ATP, in addition to MHC class I-specific peptide, ...

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