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1,192 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

Modulation of age-related insulin sensitivity by VEGF-dependent vascular plasticity in adipose tissues [Medical Sciences]

14-10-2014 | Jennifer Honek; Takahiro Seki; Hideki Iwamoto; Carina Fischer; Jingrong Li; Sharon Lim; Nilesh J. Samani; Jingwu Zan ..., Proceedings of the National Academy of Sciences current issue, 2014

Mechanisms underlying age-related obesity and insulin resistance are generally unknown. Here, we report age-related adipose vascular changes markedly modulated fat mass, adipocyte functions, blood lipid composition, and insulin sensitivity. Notably, VEGF expression levels in various white adipose ...

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Tissue injury and hypoxia promote malignant progression of prostate cancer by inducing CXCL13 expression in tumor myofibroblasts [Cell Biology]

14-10-2014 | Massimo Ammirante; Shabnam Shalapour; Youngjin Kang; Christina A. M. Jamieson; Michael Karin, Proceedings of the National Academy of Sciences current issue, 2014

Prostate cancer (PC) is a slowly progressing malignancy that often responds to androgen ablation or chemotherapy by becoming more aggressive, acquiring a neuroendocrine phenotype, and undergoing metastatic spread. We found that B lymphocytes recruited into regressing androgen-deprived tumors by ...

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Insulin and insulin-like growth factor 1 receptors are required for normal expression of imprinted genes [Medical Sciences]

07-10-2014 | Jeremie Boucher; Marika Charalambous; Kim Zarse; Marcelo A. Mori; Andre Kleinridders; Michael Ristow; Anne C. Fergus ..., Proceedings of the National Academy of Sciences current issue, 2014

In addition to signaling through the classical tyrosine kinase pathway, recent studies indicate that insulin receptors (IRs) and insulin-like growth factor 1 (IGF1) receptors (IGF1Rs) can emit signals in the unoccupied state through some yet-to-be-defined noncanonical pathways. Here we show that ...

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Phospholipase C{delta}1 induces E-cadherin expression and suppresses malignancy in colorectal cancer cells [Medical Sciences]

16-09-2014 | Reiko Satow; Tamaki Hirano; Ryosuke Batori; Tomomi Nakamura; Yumi Murayama; Kiyoko Fukami, Proceedings of the National Academy of Sciences current issue, 2014

Colorectal cancer (CRC) is one of the most common causes of cancer-related deaths worldwide, and Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations in CRC predict the ineffectiveness of EGF receptor-targeted therapy. Previous transcriptional microarray analysis suggests the association ...

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Expression profiling associates blood and brain glucocorticoid receptor signaling with trauma-related individual differences in both sexes [Neuroscience]

16-09-2014 | Nikolaos P. Daskalakis; Hagit Cohen; Guiqing Cai; Joseph D. Buxbaum; Rachel Yehuda, Proceedings of the National Academy of Sciences current issue, 2014

Delineating the molecular basis of individual differences in the stress response is critical to understanding the pathophysiology and treatment of posttraumatic stress disorder (PTSD). In this study, 7 d after predator-scent-stress (PSS) exposure, male and female rats were classified into ...

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Profile of William R. Jacobs, Jr. [Profiles]

16-09-2014 | Ann Griswold, Proceedings of the National Academy of Sciences current issue, 2014

The expression on the young man’s face as he stood by the railing surrounding the zebra enclosure at the Bronx Zoo might have been mistaken for awe at the animals’ magnificent hides or spry gaits. However, as the man reached into the enclosure and scooped a clump of soil and...

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Stat3 promotes IL-10 expression in lupus T cells through trans-activation and chromatin remodeling [Immunology and Inflammation]

16-09-2014 | Christian M. Hedrich; Thomas Rauen; Sokratis A. Apostolidis; Alexandros P. Grammatikos; Noe Rodriguez Rodriguez; Chr ..., Proceedings of the National Academy of Sciences current issue, 2014

The immune-regulatory cytokine IL-10 plays a central role during innate and adaptive immune responses. IL-10 is elevated in the serum and tissues of patients with systemic lupus erythematosus (SLE), an autoimmune disorder characterized by autoantibody production, immune-complex formation, and ...

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Overactivation of corticotropin-releasing factor receptor type 1 and aquaporin-4 by hypoxia induces cerebral edema [Neuroscience]

09-09-2014 | Shao-Jun Chen; Jia-Fang Yang; Fan-Ping Kong; Ji-Long Ren; Ke Hao; Min Li; Yuan Yuan; Xin-Can Chen; Ri-Sheng Yu; Jun- ..., Proceedings of the National Academy of Sciences current issue, 2014

Cerebral edema is a potentially life-threatening illness, but knowledge of its underlying mechanisms is limited. Here we report that hypobaric hypoxia induces rat cerebral edema and neuronal apoptosis and increases the expression of corticotrophin releasing factor (CRF), CRF receptor type 1 ...

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The class III ribonucleotide reductase from Neisseria bacilliformis can utilize thioredoxin as a reductant [Biochemistry]

09-09-2014 | Yifeng Wei; Michael A. Funk; Leonardo A. Rosado; Jiyeon Baek; Catherine L. Drennan; JoAnne Stubbe, Proceedings of the National Academy of Sciences current issue, 2014

The class III anaerobic ribonucleotide reductases (RNRs) studied to date couple the reduction of ribonucleotides to deoxynucleotides with the oxidation of formate to CO2. Here we report the cloning and heterologous expression of the Neisseria bacilliformis class III RNR and show that it can ...

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Genetic and pharmacological reactivation of the mammalian inactive X chromosome [Cell Biology]

02-09-2014 | Sanchita Bhatnagar; Xiaochun Zhu; Jianhong Ou; Ling Lin; Lynn Chamberlain; Lihua J. Zhu; Narendra Wajapeyee; Michael ..., Proceedings of the National Academy of Sciences current issue, 2014

X-chromosome inactivation (XCI), the random transcriptional silencing of one X chromosome in somatic cells of female mammals, is a mechanism that ensures equal expression of X-linked genes in both sexes. XCI is initiated in cis by the noncoding Xist RNA, which coats the inactive X chromosome (Xi) ...

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