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1,229 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

Constraints on the evolution of a doublesex target gene arising from doublesex's pleiotropic deployment [Genetics]

24-Feb-2015 | Shengzhan D. Luo; Bruce S. Baker, Proceedings of the National Academy of Sciences current issue, 2015

“Regulatory evolution,” that is, changes in a gene’s expression pattern through changes at its regulatory sequence, rather than changes at the coding sequence of the gene or changes of the upstream transcription factors, has been increasingly recognized as a pervasive evolution mechanism. Many ...

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Low expression of CD39 on regulatory T cells as a biomarker for resistance to methotrexate therapy in rheumatoid arthritis [Medical Sciences]

24-Feb-2015 | Raphael Sanches Peres; Foo Y. Liew; Jhimmy Talbot; Vanessa Carregaro; Rene D. Oliveira; Sergio L. Almeida; Rafael F. ..., Proceedings of the National Academy of Sciences current issue, 2015

Rheumatoid arthritis (RA) is an inflammatory autoimmune disease characterized by joint destruction and severe morbidity. Methotrexate (MTX) is the standard first-line therapy of RA. However, about 40% of RA patients are unresponsive to MTX treatment. Regulatory T cells (Tregs, CD4+CD25+FoxP3+) ...

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The SWI/SNF chromatin remodeling complex regulates germinal center formation by repressing Blimp-1 expression [Immunology and Inflammation]

17-Feb-2015 | Jinwook Choi; Shin Jeon; Seungjin Choi; Kyungsoo Park; Rho Hyun Seong, Proceedings of the National Academy of Sciences current issue, 2015

Germinal center (GC) reaction is crucial in adaptive immune responses. The formation of GC is coordinated by the expression of specific genes including Blimp-1 and Bcl-6. Although gene expression is critically influenced by the status of chromatin structure, little is known about the role of ...

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Quorum sensing and policing of Pseudomonas aeruginosa social cheaters [Microbiology]

17-Feb-2015 | Meizhen Wang; Amy L. Schaefer; Ajai A. Dandekar; E. Peter Greenberg, Proceedings of the National Academy of Sciences current issue, 2015

The bacterium Pseudomonas aeruginosa is an opportunistic human pathogen that uses a quorum sensing signal cascade to activate expression of dozens of genes when sufficient population densities have been reached. Quorum sensing controls production of several key virulence factors, including ...

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Double-stranded RNA made in C. elegans neurons can enter the germline and cause transgenerational gene silencing [Genetics]

17-Feb-2015 | Sindhuja Devanapally; Snusha Ravikumar; Antony M. Jose, Proceedings of the National Academy of Sciences current issue, 2015

An animal that can transfer gene-regulatory information from somatic cells to germ cells may be able to communicate changes in the soma from one generation to the next. In the worm Caenorhabditis elegans, expression of double-stranded RNA (dsRNA) in neurons can result in the export of ...

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BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma model [Cell Biology]

10-Feb-2015 | Daniele Perna; Florian A. Karreth; Alistair G. Rust; Pedro A. Perez-Mancera; Mamunur Rashid; Francesco Iorio; Consta ..., Proceedings of the National Academy of Sciences current issue, 2015

BRAF (v-raf murine sarcoma viral oncogene homolog B) inhibitors elicit a transient anti-tumor response in ∼80% of BRAFV600-mutant melanoma patients that almost uniformly precedes the emergence of resistance. Here we used a mouse model of melanoma in which melanocyte-specific expression of ...

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Neuronal UCP1 expression suggests a mechanism for local thermogenesis during hibernation [Physiology]

03-Feb-2015 | Willem J. Laursen; Marco Mastrotto; Dominik Pesta; Owen H. Funk; Jena B. Goodman; Dana K. Merriman; Nicholas Ingolia ..., Proceedings of the National Academy of Sciences current issue, 2015

Hibernating mammals possess a unique ability to reduce their body temperature to ambient levels, which can be as low as −2.9 °C, by active down-regulation of metabolism. Despite such a depressed physiologic phenotype, hibernators still maintain activity in their nervous systems, as evidenced by ...

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NAD kinase controls animal NADP biosynthesis and is modulated via evolutionarily divergent calmodulin-dependent mechanisms [Biochemistry]

03-Feb-2015 | Nick R. Love; Nadine Pollak; Christian Dölle; Marc Niere; Yaoyao Chen; Paola Oliveri; Enrique Amaya; Sandip Patel; M ..., Proceedings of the National Academy of Sciences current issue, 2015

Nicotinamide adenine dinucleotide phosphate (NADP) is a critical cofactor during metabolism, calcium signaling, and oxidative defense, yet how animals regulate their NADP pools in vivo and how NADP-synthesizing enzymes are regulated have long remained unknown. Here we show that expression of ...

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Examination of HER3 targeting in cancer using monoclonal antibodies [Medical Sciences]

20-Jan-2015 | Nadège Gaborit; Ali Abdul-Hai; Maicol Mancini; Moshit Lindzen; Sara Lavi; Orith Leitner; Lucile Mounier; Myriam Chen ..., Proceedings of the National Academy of Sciences current issue, 2015

The human EGF receptor (HER/EGFR) family of receptor tyrosine kinases serves as a key target for cancer therapy. Specifically, EGFR and HER2 have been repeatedly targeted because of their genetic aberrations in tumors. The therapeutic potential of targeting HER3 has long been underestimated, due ...

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Natural diversity in daily rhythms of gene expression contributes to phenotypic variation [Plant Biology]

20-Jan-2015 | Amaury de Montaigu; Antonis Giakountis; Matthew Rubin; Réka Tóth; Frédéric Cremer; Vladislava Sokolova; Aimone Porri ..., Proceedings of the National Academy of Sciences current issue, 2015

Daily rhythms of gene expression provide a benefit to most organisms by ensuring that biological processes are activated at the optimal time of day. Although temporal patterns of expression control plant traits of agricultural importance, how natural genetic variation modifies these patterns ...

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