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1,387 Newest Publications in proceedings of the national academy of sciences current issue

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Detecting affiliation in colaughter across 24 societies [Psychological and Cognitive Sciences]

26-Apr-2016 | Gregory A. Bryant; Daniel M. T. Fessler; Riccardo Fusaroli; Edward Clint; Lene Aarøe; Coren L. Apicella; Michael Ban ..., Proceedings of the National Academy of Sciences current issue, 2016

Laughter is a nonverbal vocal expression that often communicates positive affect and cooperative intent in humans. Temporally coincident laughter occurring within groups is a potentially rich cue of affiliation to overhearers. We examined listeners’ judgments of affiliation based on brief, ...

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Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood [Immunology and Inflammation]

26-Apr-2016 | Katrin Klocke; Shimon Sakaguchi; Rikard Holmdahl; Kajsa Wing, Proceedings of the National Academy of Sciences current issue, 2016

Cytotoxic T lymphocyte antigen-4 (CTLA-4) is essential for immunological (self-) tolerance, but due to the early fatality of CTLA-4 KO mice, its specific function in central and peripheral tolerance and in different systemic diseases remains to be determined. Here, we further examined the role of ...

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Stability-driven nonnegative matrix factorization to interpret spatial gene expression and build local gene networks [Systems Biology]

19-Apr-2016 | Siqi Wu; Antony Joseph; Ann S. Hammonds; Susan E. Celniker; Bin Yu; Erwin Frise, Proceedings of the National Academy of Sciences current issue, 2016

Spatial gene expression patterns enable the detection of local covariability and are extremely useful for identifying local gene interactions during normal development. The abundance of spatial expression data in recent years has led to the modeling and analysis of regulatory networks. The ...

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Pathogen receptor discovery with a microfluidic human membrane protein array [Biophysics and Computational Biology]

19-Apr-2016 | Yair Glick; Ya’ara Ben-Ari; Nir Drayman; Michal Pellach; Gregory Neveu; Jim Boonyaratanakornkit; Dorit Avrahami; Shi ..., Proceedings of the National Academy of Sciences current issue, 2016

The discovery of how a pathogen invades a cell requires one to determine which host cell receptors are exploited. This determination is a challenging problem because the receptor is invariably a membrane protein, which represents an Achilles heel in proteomics. We have developed a universal ...

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Heterodimerization within the TREK channel subfamily produces a diverse family of highly regulated potassium channels [Neuroscience]

12-Apr-2016 | Joshua Levitz; Perrine Royal; Yannick Comoglio; Brigitte Wdziekonski; Sébastien Schaub; Daniel M. Clemens; Ehud Y. I ..., Proceedings of the National Academy of Sciences current issue, 2016

Twik-related K+ channel 1 (TREK1), TREK2, and Twik-related arachidonic-acid stimulated K+ channel (TRAAK) form the TREK subfamily of two-pore-domain K+ (K2P) channels. Despite sharing up to 78% sequence homology and overlapping expression profiles in the nervous system, these channels show major ...

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Paclitaxel-induced epithelial damage and ectopic MMP-13 expression promotes neurotoxicity in zebrafish [Neuroscience]

12-Apr-2016 | Thomas S. Lisse; Leah J. Middleton; Adriana D. Pellegrini; Paige B. Martin; Emily L. Spaulding; Olivia Lopes; Elizab ..., Proceedings of the National Academy of Sciences current issue, 2016

Paclitaxel is a microtubule-stabilizing chemotherapeutic agent that is widely used in cancer treatment and in a number of curative and palliative regimens. Despite its beneficial effects on cancer, paclitaxel also damages healthy tissues, most prominently the peripheral sensory nervous system. ...

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Retraction for Dong et al., Deficient Smad7 expression: A putative molecular defect in scleroderma [Retractions]

12-Apr-2016 | Proceedings of the National Academy of Sciences current issue, 2016

MEDICAL SCIENCES Retraction for “Deficient Smad7 expression: A putative molecular defect in scleroderma,” by Chunming Dong, Shoukang Zhu, Tao Wang, Woohyun Yoon, Zhiru Li, Rene J. Alvarez, Peter ten Dijke, Barbara White, Fredrick M. Wigley, and Pascal J. Goldschmidt-Clermont, which appeared in ...

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Anabolic actions of Notch on mature bone [Medical Sciences]

12-Apr-2016 | Peng Liu; Yilin Ping; Meng Ma; Demao Zhang; Connie Liu; Samir Zaidi; Song Gao; Yaoting Ji; Feng Lou; Fanyuan Yu; Pin ..., Proceedings of the National Academy of Sciences current issue, 2016

Notch controls skeletogenesis, but its role in the remodeling of adult bone remains conflicting. In mature mice, the skeleton can become osteopenic or osteosclerotic depending on the time point at which Notch is activated or inactivated. Using adult EGFP reporter mice, we find that Notch ...

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Rapid evolution of a Y-chromosome heterochromatin protein underlies sex chromosome meiotic drive [Evolution]

12-Apr-2016 | Quentin Helleu; Pierre R. Gérard; Raphaëlle Dubruille; David Ogereau; Benjamin Prud’homme; Benjamin Loppin; Catherin ..., Proceedings of the National Academy of Sciences current issue, 2016

Sex chromosome meiotic drive, the non-Mendelian transmission of sex chromosomes, is the expression of an intragenomic conflict that can have extreme evolutionary consequences. However, the molecular bases of such conflicts remain poorly understood. Here, we show that a young and rapidly evolving ...

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Myofibroblasts are distinguished from activated skin fibroblasts by the expression of AOC3 and other associated markers [Medical Sciences]

12-Apr-2016 | Lin-ting Hsia; Neil Ashley; Djamila Ouaret; Lai Mun Wang; Jennifer Wilding; Walter F. Bodmer, Proceedings of the National Academy of Sciences current issue, 2016

Pericryptal myofibroblasts in the colon and rectum play an important role in regulating the normal colorectal stem cell niche and facilitating tumor progression. Myofibroblasts previously have been distinguished from normal fibroblasts mostly by the expression of α smooth muscle actin (αSMA). We ...

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