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1,236 Newest Publications in proceedings of the national academy of sciences current issue

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Extraordinary diversity of visual opsin genes in dragonflies [Evolution]

17-Mar-2015 | Ryo Futahashi; Ryouka Kawahara-Miki; Michiyo Kinoshita; Kazutoshi Yoshitake; Shunsuke Yajima; Kentaro Arikawa; Takem ..., Proceedings of the National Academy of Sciences current issue, 2015

Dragonflies are colorful and large-eyed animals strongly dependent on color vision. Here we report an extraordinary large number of opsin genes in dragonflies and their characteristic spatiotemporal expression patterns. Exhaustive transcriptomic and genomic surveys of three dragonflies of the ...

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Quorum-sensing Salmonella selectively trigger protein expression within tumors [Engineering]

17-Mar-2015 | Charles A. Swofford; Nele Van Dessel; Neil S. Forbes, Proceedings of the National Academy of Sciences current issue, 2015

Salmonella that secrete anticancer proteins have the potential to eliminate tumors, but nonspecific expression causes damage to healthy tissue. We hypothesize that Salmonella, integrated with a density-dependent switch, would only express proteins in tightly packed colonies within tumors. To test ...

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The RNA binding protein FXR1 is a new driver in the 3q26-29 amplicon and predicts poor prognosis in human cancers [Medical Sciences]

17-Mar-2015 | Jun Qian; Mohamed Hassanein; Megan D. Hoeksema; Bradford K. Harris; Yong Zou; Heidi Chen; Pengcheng Lu; Rosana Eisen ..., Proceedings of the National Academy of Sciences current issue, 2015

Aberrant expression of RNA-binding proteins has profound implications for cellular physiology and the pathogenesis of human diseases such as cancer. We previously identified the Fragile X-Related 1 gene (FXR1) as one amplified candidate driver gene at 3q26-29 in lung squamous cell carcinoma ...

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Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs [Genetics]

10-Mar-2015 | Eric Londin; Phillipe Loher; Aristeidis G. Telonis; Kevin Quann; Peter Clark; Yi Jing; Eleftheria Hatzimichael; Yohe ..., Proceedings of the National Academy of Sciences current issue, 2015

Two decades after the discovery of the first animal microRNA (miRNA), the number of miRNAs in animal genomes remains a vexing question. Here, we report findings from analyzing 1,323 short RNA sequencing samples (RNA-seq) from 13 different human tissue types. Using stringent thresholding criteria, ...

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Detecting cancers through tumor-activatable minicircles that lead to a detectable blood biomarker [Medical Sciences]

10-Mar-2015 | John A. Ronald; Hui-Yen Chuang; Anca Dragulescu-Andrasi; Sharon S. Hori; Sanjiv S. Gambhir, Proceedings of the National Academy of Sciences current issue, 2015

Earlier detection of cancers can dramatically improve the efficacy of available treatment strategies. However, despite decades of effort on blood-based biomarker cancer detection, many promising endogenous biomarkers have failed clinically because of intractable problems such as highly variable ...

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Antisense long noncoding RNAs regulate var gene activation in the malaria parasite Plasmodium falciparum [Microbiology]

03-Mar-2015 | Inbar Amit-Avraham; Guy Pozner; Shiri Eshar; Yair Fastman; Netanel Kolevzon; Eylon Yavin; Ron Dzikowski, Proceedings of the National Academy of Sciences current issue, 2015

The virulence of Plasmodium falciparum, the causative agent of the deadliest form of human malaria, is attributed to its ability to evade human immunity through antigenic variation. These parasites alternate between expression of variable antigens, encoded by members of a multicopy gene family ...

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APOBEC3B expression in breast cancer reflects cellular proliferation, while a deletion polymorphism is associated with immune activation [Medical Sciences]

03-Mar-2015 | David W. Cescon; Benjamin Haibe-Kains; Tak W. Mak, Proceedings of the National Academy of Sciences current issue, 2015

Genomic sequencing studies of breast and other cancers have identified patterns of mutations that have been attributed to the endogenous mutator activity of APOBEC3B (A3B), a member of the AID/APOBEC family of cytidine deaminases. A3B gene expression is increased in many cancers, but its upstream ...

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Constraints on the evolution of a doublesex target gene arising from doublesex's pleiotropic deployment [Genetics]

24-Feb-2015 | Shengzhan D. Luo; Bruce S. Baker, Proceedings of the National Academy of Sciences current issue, 2015

“Regulatory evolution,” that is, changes in a gene’s expression pattern through changes at its regulatory sequence, rather than changes at the coding sequence of the gene or changes of the upstream transcription factors, has been increasingly recognized as a pervasive evolution mechanism. Many ...

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Low expression of CD39 on regulatory T cells as a biomarker for resistance to methotrexate therapy in rheumatoid arthritis [Medical Sciences]

24-Feb-2015 | Raphael Sanches Peres; Foo Y. Liew; Jhimmy Talbot; Vanessa Carregaro; Rene D. Oliveira; Sergio L. Almeida; Rafael F. ..., Proceedings of the National Academy of Sciences current issue, 2015

Rheumatoid arthritis (RA) is an inflammatory autoimmune disease characterized by joint destruction and severe morbidity. Methotrexate (MTX) is the standard first-line therapy of RA. However, about 40% of RA patients are unresponsive to MTX treatment. Regulatory T cells (Tregs, CD4+CD25+FoxP3+) ...

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The SWI/SNF chromatin remodeling complex regulates germinal center formation by repressing Blimp-1 expression [Immunology and Inflammation]

17-Feb-2015 | Jinwook Choi; Shin Jeon; Seungjin Choi; Kyungsoo Park; Rho Hyun Seong, Proceedings of the National Academy of Sciences current issue, 2015

Germinal center (GC) reaction is crucial in adaptive immune responses. The formation of GC is coordinated by the expression of specific genes including Blimp-1 and Bcl-6. Although gene expression is critically influenced by the status of chromatin structure, little is known about the role of ...

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