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1,156 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

Role of activity-dependent BDNF expression in hippocampal-prefrontal cortical regulation of behavioral perseverance [Neuroscience]

10-09-2013 | Kazuko Sakata; Keri Martinowich; Newton H. Woo; Robert J. Schloesser; Dennisse V. Jimenez; Yuanyuan Ji; Liya Shen; B ..., Proceedings of the National Academy of Sciences current issue, 2013

Activity-dependent gene transcription, including that of the brain-derived neurotrophic factor (Bdnf) gene, has been implicated in various cognitive functions. We previously demonstrated that mutant mice with selective disruption of activity-dependent BDNF expression (BDNF-KIV mice) exhibit ...

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Natalisin, a tachykinin-like signaling system, regulates sexual activity and fecundity in insects [Neuroscience]

10-09-2013 | Hongbo Jiang; Ankhbayar Lkhagva; Ivana Daubnerová; Hyo-Seok Chae; Ladislav Šimo; Sung-Hwan Jung; Yeu-Kyung Yoon; Na- ..., Proceedings of the National Academy of Sciences current issue, 2013

An arthropod-specific peptidergic system, the neuropeptide designated here as natalisin and its receptor, was identified and investigated in three holometabolous insect species: Drosophila melanogaster, Tribolium castaneum, and Bombyx mori. In all three species, natalisin expression was observed ...

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Dissection of the BCR-ABL signaling network using highly specific monobody inhibitors to the SHP2 SH2 domains [Biochemistry]

10-09-2013 | Fern Sha; Emel Basak Gencer; Sandrine Georgeon; Akiko Koide; Norihisa Yasui; Shohei Koide; Oliver Hantschel, Proceedings of the National Academy of Sciences current issue, 2013

The dysregulated tyrosine kinase BCR-ABL causes chronic myelogenous leukemia in humans and forms a large multiprotein complex that includes the Src-homology 2 (SH2) domain-containing phosphatase 2 (SHP2). The expression of SHP2 is necessary for BCR-ABL-dependent oncogenic transformation, but the ...

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Single point mutations in ATP synthase compensate for mitochondrial genome loss in trypanosomes [Microbiology]

03-09-2013 | Samuel Dean; Matthew K. Gould; Caroline E. Dewar; Achim C. Schnaufer, Proceedings of the National Academy of Sciences current issue, 2013

Viability of the tsetse fly-transmitted African trypanosome Trypanosoma brucei depends on maintenance and expression of its kinetoplast (kDNA), the mitochondrial genome of this parasite and a putative target for veterinary and human antitrypanosomatid drugs. However, the closely related animal ...

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Torso-like functions independently of Torso to regulate Drosophila growth and developmental timing [Developmental Biology]

03-09-2013 | Travis K. Johnson; Tova Crossman; Karyn A. Foote; Michelle A. Henstridge; Melissa J. Saligari; Lauren Forbes Beadle; ..., Proceedings of the National Academy of Sciences current issue, 2013

Activation of the Drosophila receptor tyrosine kinase Torso (Tor) only at the termini of the embryo is achieved by the localized expression of the maternal gene Torso-like (Tsl). Tor has a second function in the prothoracic gland as the receptor for prothoracicotropic hormone (PTTH) that ...

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WNK1-related Familial Hyperkalemic Hypertension results from an increased expression of L-WNK1 specifically in the distal nephron [Medical Sciences]

27-08-2013 | Emmanuelle Vidal-Petiot; Emilie Elvira-Matelot; Kerim Mutig; Christelle Soukaseum; Véronique Baudrie; Shengnan Wu; L ..., Proceedings of the National Academy of Sciences current issue, 2013

Large deletions in the first intron of the With No lysine (K) 1 (WNK1) gene are responsible for Familial Hyperkalemic Hypertension (FHHt), a rare form of human hypertension associated with hyperkalemia and hyperchloremic metabolic acidosis. We generated a mouse model of WNK1-associated FHHt to ...

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Creating memories of transcription [Systems Biology]

20-08-2013 | Ann L. Kirchmaier, Proceedings of the National Academy of Sciences current issue, 2013

Two genetically identical cells grown under the same conditions can exhibit stochastic fluctuations in gene expression. Such cell-to-cell variation in expression of key genes is hypothesized to help drive developmental fate decisions and cell specialization during differentiation. However, to ...

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Stochastic expression and epigenetic memory at the yeast HO promoter [Systems Biology]

20-08-2013 | Qian Zhang; Youngdae Yoon; Yaxin Yu; Emily J. Parnell; Juan Antonio Raygoza Garay; Michael M. Mwangi; Frederick R. C ..., Proceedings of the National Academy of Sciences current issue, 2013

Eukaryotic gene regulation usually involves sequence-specific transcription factors and sequence-nonspecific cofactors. A large effort has been made to understand how these factors affect the average gene expression level among a population. However, little is known about how they regulate gene ...

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Skin-specific expression of IL-33 activates group 2 innate lymphoid cells and elicits atopic dermatitis-like inflammation in mice [Immunology]

20-08-2013 | Yasutomo Imai; Koubun Yasuda; Yoshiko Sakaguchi; Takashi Haneda; Hitoshi Mizutani; Tomohiro Yoshimoto; Kenji Nakanis ..., Proceedings of the National Academy of Sciences current issue, 2013

Transgenic mice expressing the mouse interleukin 33 (IL-33) gene driven by a keratin 14 promoter were generated. The skin-selective expression of the IL-33 gene was enhanced, and intense immunofluorescence for IL-33 was evident in the nuclei of the epidermis. Spontaneous itchy dermatitis ...

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Ric-8 folding of G proteins better explains Ric-8 apparent amplification of G protein-coupled receptor signaling [Biological Sciences]

20-08-2013 | Gregory G. Tall; Bharti R. Patel; PuiYee Chan, Proceedings of the National Academy of Sciences current issue, 2013

In their PNAS article, Kataria et al. conclude that “…Dictyostelium resistant to inhibitors of cholinesterase 8 (Ric-8), in contrast to mammalian Ric-8, does not play a role in the expression or folding of G proteins.” (1) We contend that the experimental evidence presented to support this claim ...

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