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1,345 Newest Publications in proceedings of the national academy of sciences current issue

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APOL1 kidney disease risk variants cause cytotoxicity by depleting cellular potassium and inducing stress-activated protein kinases [Medical Sciences]

26-Jan-2016 | Opeyemi A. Olabisi; Jia-Yue Zhang; Lynn VerPlank; Nathan Zahler; Salvatore DiBartolo III; John F. Heneghan; Johannes ..., Proceedings of the National Academy of Sciences current issue, 2016

Two specific genetic variants of the apolipoprotein L1 (APOL1) gene are responsible for the high rate of kidney disease in people of recent African ancestry. Expression in cultured cells of these APOL1 risk variants, commonly referred to as G1 and G2, results in significant cytotoxicity. The ...

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Surface expression, peptide repertoire, and thermostability of chicken class I molecules correlate with peptide transporter specificity [Immunology and Inflammation]

19-Jan-2016 | Clive A. Tregaskes; Michael Harrison; Anna K. Sowa; Andy van Hateren; Lawrence G. Hunt; Olli Vainio; Jim Kaufman, Proceedings of the National Academy of Sciences current issue, 2016

The chicken major histocompatibility complex (MHC) has strong genetic associations with resistance and susceptibility to certain infectious pathogens. The cell surface expression level of MHC class I molecules varies as much as 10-fold between chicken haplotypes and is inversely correlated with ...

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Autoregulatory loop of nuclear corepressor 1 expression controls invasion, tumor growth, and metastasis [Medical Sciences]

19-Jan-2016 | Olaia A. Martínez-Iglesias; Elvira Alonso-Merino; Sara Gómez-Rey; Juan Pedro Velasco-Martín; Rosa Martín Orozco; Enr ..., Proceedings of the National Academy of Sciences current issue, 2016

Nuclear corepressor 1 (NCoR) associates with nuclear receptors and other transcription factors leading to transcriptional repression. We show here that NCoR depletion enhances cancer cell invasion and increases tumor growth and metastatic potential in nude mice. These changes are related to ...

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PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancer [Cell Biology]

19-Jan-2016 | Jaekwang Jeong; Joshua N. VanHouten; Pamela Dann; Wonnam Kim; Catherine Sullivan; Herbert Yu; Lance Liotta; Virginia ..., Proceedings of the National Academy of Sciences current issue, 2016

In the lactating mammary gland, the plasma membrane calcium ATPase2 (PMCA2) transports milk calcium. Its expression is activated in breast cancers, where high tumor levels predict increased mortality. We find that PMCA2 expression correlates with HER2 levels in breast cancers and that PMCA2 ...

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Heparanase-neutralizing antibodies attenuate lymphoma tumor growth and metastasis [Medical Sciences]

19-Jan-2016 | Marina Weissmann; Gil Arvatz; Netanel Horowitz; Sari Feld; Inna Naroditsky; Yi Zhang; Mary Ng; Edward Hammond; Eviat ..., Proceedings of the National Academy of Sciences current issue, 2016

Heparanase is an endoglycosidase that cleaves heparan sulfate side chains of proteoglycans, resulting in disassembly of the extracellular matrix underlying endothelial and epithelial cells and associating with enhanced cell invasion and metastasis. Heparanase expression is induced in carcinomas ...

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Systematic study of constitutive cyclooxygenase-2 expression: Role of NF-{kappa}B and NFAT transcriptional pathways [Pharmacology]

12-Jan-2016 | Nicholas S. Kirkby; Melissa V. Chan; Anne K. Zaiss; Eliana Garcia-Vaz; Jing Jiao; Lisa M. Berglund; Elena F. Verdu; ..., Proceedings of the National Academy of Sciences current issue, 2016

Cyclooxygenase-2 (COX-2) is an inducible enzyme that drives inflammation and is the therapeutic target for widely used nonsteroidal antiinflammatory drugs (NSAIDs). However, COX-2 is also constitutively expressed, in the absence of overt inflammation, with a specific tissue distribution that ...

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Correction to Supporting Information for Doucet-O'Hare et al., LINE-1 expression and retrotransposition in Barrett’s esophagus and esophageal carcinoma [SI Corrections]

05-Jan-2016 | Proceedings of the National Academy of Sciences current issue, 2016

GENETICS Correction to Supporting Information for “LINE-1 expression and retrotransposition in Barrett’s esophagus and esophageal carcinoma,” by Tara T. Doucet-O'Hare, Nemanja Rodić, Reema Sharma, Isha Darbari, Gabriela Abril, Jungbin A. Choi, Ji Young Ahn, Yulan Cheng, Robert A. Anders, Kathleen ...

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Quantitative regulation of FLC via coordinated transcriptional initiation and elongation [Plant Biology]

05-Jan-2016 | Zhe Wu; Robert Ietswaart; Fuquan Liu; Hongchun Yang; Martin Howard; Caroline Dean, Proceedings of the National Academy of Sciences current issue, 2016

The basis of quantitative regulation of gene expression is still poorly understood. In Arabidopsis thaliana, quantitative variation in expression of FLOWERING LOCUS C (FLC) influences the timing of flowering. In ambient temperatures, FLC expression is quantitatively modulated by a chromatin ...

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Evolution of haploid selection in predominantly diploid organisms [Evolution]

29-Dec-2015 | Sarah P. Otto; Michael F. Scott; Simone Immler, Proceedings of the National Academy of Sciences current issue, 2015

Diploid organisms manipulate the extent to which their haploid gametes experience selection. Animals typically produce sperm with a diploid complement of most proteins and RNA, limiting selection on the haploid genotype. Plants, however, exhibit extensive expression in pollen, with actively ...

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Specific induction of endogenous viral restriction factors using CRISPR/Cas-derived transcriptional activators [Microbiology]

29-Dec-2015 | Hal P. Bogerd; Anand V. R. Kornepati; Joy B. Marshall; Edward M. Kennedy; Bryan R. Cullen, Proceedings of the National Academy of Sciences current issue, 2015

Whereas several mammalian proteins can restrict the replication of HIV-1 and other viruses, these are often not expressed in relevant target cells. A potential method to inhibit viral replication might therefore be to use synthetic transcription factors to induce restriction factor expression. In ...

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