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1,296 Newest Publications in proceedings of the national academy of sciences current issue

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Roles of unphosphorylated ISGF3 in HCV infection and interferon responsiveness [Immunology and Inflammation]

18-Aug-2015 | Pil Soo Sung; HyeonJoo Cheon; Chung Hwan Cho; Seon-Hui Hong; Do Youn Park; Hyung-Il Seo; Su-Hyung Park; Seung Kew Yo ..., Proceedings of the National Academy of Sciences current issue, 2015

Up-regulation of IFN-stimulated genes (ISGs) is sustained in hepatitis C virus (HCV)-infected livers. Here, we investigated the mechanism of prolonged ISG expression and its role in IFN responsiveness during HCV infection in relation to unphosphorylated IFN-stimulated gene factor 3 (U-ISGF3), ...

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Local axonal protection by WldS as revealed by conditional regulation of protein stability [Neuroscience]

18-Aug-2015 | Jack T. Wang; Zachary A. Medress; Mauricio E. Vargas; Ben A. Barres, Proceedings of the National Academy of Sciences current issue, 2015

The expression of the mutant Wallerian degeneration slow (WldS) protein significantly delays axonal degeneration from various nerve injuries and in multiple species; however, the mechanism for its axonal protective property remains unclear. Although WldS is localized predominantly in the nucleus, ...

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Aldosterone-stimulating somatic gene mutations are common in normal adrenal glands [Medical Sciences]

18-Aug-2015 | Koshiro Nishimoto; Scott A. Tomlins; Rork Kuick; Andi K. Cani; Thomas J. Giordano; Daniel H. Hovelson; Chia-Jen Liu; ..., Proceedings of the National Academy of Sciences current issue, 2015

Primary aldosteronism (PA) represents the most common cause of secondary hypertension, but little is known regarding its adrenal cellular origins. Recently, aldosterone-producing cell clusters (APCCs) with high expression of aldosterone synthase (CYP11B2) were found in both normal and PA adrenal ...

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At14a-Like1 participates in membrane-associated mechanisms promoting growth during drought in Arabidopsis thaliana [Plant Biology]

18-Aug-2015 | M. Nagaraj Kumar; Yi-Fang Hsieh; Paul E. Verslues, Proceedings of the National Academy of Sciences current issue, 2015

Limited knowledge of how plants regulate their growth and metabolism in response to drought and reduced soil water potential has impeded efforts to improve stress tolerance. Increased expression of the membrane-associated protein At14a-like1 (AFL1) led to increased growth and accumulation of the ...

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Role of ubiquitin and the HPV E6 oncoprotein in E6AP-mediated ubiquitination [Biochemistry]

11-Aug-2015 | Franziska Mortensen; Daniel Schneider; Tanja Barbic; Anna Sladewska-Marquardt; Simone Kühnle; Andreas Marx; Martin S ..., Proceedings of the National Academy of Sciences current issue, 2015

Deregulation of the ubiquitin ligase E6 associated protein (E6AP) encoded by the UBE3A gene has been associated with three different clinical pictures. Hijacking of E6AP by the E6 oncoprotein of distinct human papillomaviruses (HPV) contributes to the development of cervical cancer, whereas loss ...

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Correction for Tackenberg et al., Impaired inhibitory Fc{gamma} receptor IIB expression on B cells in chronic inflammatory demyelinating polyneuropathy [Correction]

04-Aug-2015 | Proceedings of the National Academy of Sciences current issue, 2015

IMMUNOLOGY Correction for “Impaired inhibitory Fcγ receptor IIB expression on B cells in chronic inflammatory demyelinating polyneuropathy,” by Björn Tackenberg, Ilijas Jelčić, Anne Baerenwaldt, Wolfgang H. Oertel, Norbert Sommer, Falk Nimmerjahn, and Jan D. Lünemann, which appeared in issue 12, ...

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Replacing SNAP-25b with SNAP-25a expression results in metabolic disease [Physiology]

04-Aug-2015 | Ismael Valladolid-Acebes; Teresa Daraio; Kerstin Brismar; Tibor Harkany; Sven Ove Ögren; Tomas G. M. Hökfelt; Christ ..., Proceedings of the National Academy of Sciences current issue, 2015

Synaptosomal-associated protein of 25 kDa (SNAP-25) is a key molecule in the soluble N-ethylmaleimide–sensitive factor attachment protein (SNARE) complex mediating fast Ca2+-triggered release of hormones and neurotransmitters, and both splice variants, SNAP-25a and SNAP-25b, can participate in ...

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Erlotinib protects against LPS-induced Endotoxicity because TLR4 needs EGFR to signal [Immunology and Inflammation]

04-Aug-2015 | Sarmishtha De; Hao Zhou; David DeSantis; Colleen M. Croniger; Xiaoxia Li; George R. Stark, Proceedings of the National Academy of Sciences current issue, 2015

Several components of the canonical pathway of response to lipopolysaccharide (LPS) are required for the EGF-dependent activation of NFκB. Conversely, the ability of Toll-like Receptor 4 (TLR4) to activate NFκB in response to LPS is impaired by down regulating EGF receptor (EGFR) expression or by ...

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Memory formation and retrieval of neuronal silencing in the auditory cortex [Neuroscience]

04-Aug-2015 | Hiroshi Nomura; Kojiro Hara; Reimi Abe; Natsuko Hitora-Imamura; Ryota Nakayama; Takuya Sasaki; Norio Matsuki; Yuji I ..., Proceedings of the National Academy of Sciences current issue, 2015

Sensory stimuli not only activate specific populations of cortical neurons but can also silence other populations. However, it remains unclear whether neuronal silencing per se leads to memory formation and behavioral expression. Here we show that mice can report optogenetic inactivation of ...

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Functional expression of sodium-glucose transporters in cancer [Medical Sciences]

28-Jul-2015 | Claudio Scafoglio; Bruce A. Hirayama; Vladimir Kepe; Jie Liu; Chiara Ghezzi; Nagichettiar Satyamurthy; Neda A. Moata ..., Proceedings of the National Academy of Sciences current issue, 2015

Glucose is a major metabolic substrate required for cancer cell survival and growth. It is mainly imported into cells by facilitated glucose transporters (GLUTs). Here we demonstrate the importance of another glucose import system, the sodium-dependent glucose transporters (SGLTs), in pancreatic ...

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