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1,199 Newest Publications in proceedings of the national academy of sciences current issue

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Correction for Wenz et al., Increased muscle PGC-1{alpha} expression protects from sarcopenia and metabolic disease during aging [Corrections]

04-11-2014 | Proceedings of the National Academy of Sciences current issue, 2014

MEDICAL SCIENCES Correction for “Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease during aging,” by Tina Wenz, Susana G. Rossi, Richard L. Rotundo, Bruce M. Spiegelman, and Carlos T. Moraes, which appeared in issue 48, December 1, 2009, of Proc Natl Acad Sci USA ...

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Molecular basis of mycobacterial lipid antigen presentation by CD1c and its recognition by {alpha}{beta} T cells [Immunology and Inflammation]

28-10-2014 | Sobhan Roy; Dalam Ly; Nan-Sheng Li; John D. Altman; Joseph A. Piccirilli; D. Branch Moody; Erin J. Adams, Proceedings of the National Academy of Sciences current issue, 2014

CD1c is a member of the group 1 CD1 family of proteins that are specialized for lipid antigen presentation. Despite high cell surface expression of CD1c on key antigen-presenting cells and the discovery of its mycobacterial lipid antigen presentation capability, the molecular basis of CD1c ...

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LIMP-2 expression is critical for {beta}-glucocerebrosidase activity and {alpha}-synuclein clearance [Neuroscience]

28-10-2014 | Michelle Rothaug; Friederike Zunke; Joseph R. Mazzulli; Michaela Schweizer; Hermann Altmeppen; Renate Lüllmann-Rauch ..., Proceedings of the National Academy of Sciences current issue, 2014

Mutations within the lysosomal enzyme β-glucocerebrosidase (GC) result in Gaucher disease and represent a major risk factor for developing Parkinson disease (PD). Loss of GC activity leads to accumulation of its substrate glucosylceramide and α-synuclein. Since lysosomal activity of GC is tightly ...

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Caenorhabditis elegans period homolog lin-42 regulates the timing of heterochronic miRNA expression [Developmental Biology]

28-10-2014 | Katherine A. McCulloch; Ann E. Rougvie, Proceedings of the National Academy of Sciences current issue, 2014

MicroRNAs (miRNAs) are small RNAs that regulate gene expression posttranscriptionally via the 3′ UTR of target mRNAs and were first identified in the Caenorhabditis elegans heterochronic pathway. miRNAs have since been found in many organisms and have broad functions, including control of ...

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Reply to Leithner et al.: Focus on phopshoenolpyruvate carboxykinase (PEPCK): A target of the p53-SIRT6-FoxO1 axis [Biological Sciences]

21-10-2014 | Zhiming Li; Wei-Guo Zhu, Proceedings of the National Academy of Sciences current issue, 2014

Cancer metabolism has drawn widespread attention since the unique metabolic properties of cancer cells were characterized. We found that p53, a potent tumor suppressor, down-regulates the expression of phopshoenolpyruvate carboxykinase (PEPCK, PCK1) in coordination with histone deacetylase ...

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CHD8 regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors [Genetics]

21-10-2014 | Aarathi Sugathan; Marta Biagioli; Christelle Golzio; Serkan Erdin; Ian Blumenthal; Poornima Manavalan; Ashok Ragaven ..., Proceedings of the National Academy of Sciences current issue, 2014

Truncating mutations of chromodomain helicase DNA-binding protein 8 (CHD8), and of many other genes with diverse functions, are strong-effect risk factors for autism spectrum disorder (ASD), suggesting multiple mechanisms of pathogenesis. We explored the transcriptional networks that CHD8 ...

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Netrin-4 regulates thalamocortical axon branching in an activity-dependent fashion [Neuroscience]

21-10-2014 | Yasufumi Hayano; Kensuke Sasaki; Nami Ohmura; Makoto Takemoto; Yurie Maeda; Toshihide Yamashita; Yoshio Hata; Kazuhi ..., Proceedings of the National Academy of Sciences current issue, 2014

Axon branching is remodeled by sensory-evoked and spontaneous neuronal activity. However, the underlying molecular mechanism is largely unknown. Here, we demonstrate that the netrin family member netrin-4 (NTN4) contributes to activity-dependent thalamocortical (TC) axon branching. In the ...

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Modulation of age-related insulin sensitivity by VEGF-dependent vascular plasticity in adipose tissues [Medical Sciences]

14-10-2014 | Jennifer Honek; Takahiro Seki; Hideki Iwamoto; Carina Fischer; Jingrong Li; Sharon Lim; Nilesh J. Samani; Jingwu Zan ..., Proceedings of the National Academy of Sciences current issue, 2014

Mechanisms underlying age-related obesity and insulin resistance are generally unknown. Here, we report age-related adipose vascular changes markedly modulated fat mass, adipocyte functions, blood lipid composition, and insulin sensitivity. Notably, VEGF expression levels in various white adipose ...

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Tissue injury and hypoxia promote malignant progression of prostate cancer by inducing CXCL13 expression in tumor myofibroblasts [Cell Biology]

14-10-2014 | Massimo Ammirante; Shabnam Shalapour; Youngjin Kang; Christina A. M. Jamieson; Michael Karin, Proceedings of the National Academy of Sciences current issue, 2014

Prostate cancer (PC) is a slowly progressing malignancy that often responds to androgen ablation or chemotherapy by becoming more aggressive, acquiring a neuroendocrine phenotype, and undergoing metastatic spread. We found that B lymphocytes recruited into regressing androgen-deprived tumors by ...

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Insulin and insulin-like growth factor 1 receptors are required for normal expression of imprinted genes [Medical Sciences]

07-10-2014 | Jeremie Boucher; Marika Charalambous; Kim Zarse; Marcelo A. Mori; Andre Kleinridders; Michael Ristow; Anne C. Fergus ..., Proceedings of the National Academy of Sciences current issue, 2014

In addition to signaling through the classical tyrosine kinase pathway, recent studies indicate that insulin receptors (IRs) and insulin-like growth factor 1 (IGF1) receptors (IGF1Rs) can emit signals in the unoccupied state through some yet-to-be-defined noncanonical pathways. Here we show that ...

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