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1,243 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

Hedgehog signaling activates a positive feedback mechanism involving insulin-like growth factors to induce osteoblast differentiation [Developmental Biology]

14-Apr-2015 | Yu Shi; Jianquan Chen; Courtney M. Karner; Fanxin Long, Proceedings of the National Academy of Sciences current issue, 2015

Hedgehog (Hh) signaling is essential for osteoblast differentiation in the endochondral skeleton during embryogenesis. However, the molecular mechanism underlying the osteoblastogenic role of Hh is not completely understood. Here, we report that Hh markedly induces the expression of insulin-like ...

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Dynamin 2-dependent endocytosis sustains T-cell receptor signaling and drives metabolic reprogramming in T lymphocytes [Immunology and Inflammation]

07-Apr-2015 | Tim Willinger; Matthew Staron; Shawn M. Ferguson; Pietro De Camilli; Richard A. Flavell, Proceedings of the National Academy of Sciences current issue, 2015

Prolonged T-cell receptor (TCR) signaling is required for the proliferation of T lymphocytes. Ligation of the TCR activates signaling, but also causes internalization of the TCR from the cell surface. How TCR signaling is sustained for many hours despite lower surface expression is unknown. Using ...

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Candidate ionotropic taste receptors in the Drosophila larva [Neuroscience]

07-Apr-2015 | Shannon Stewart; Tong-Wey Koh; Arpan C. Ghosh; John R. Carlson, Proceedings of the National Academy of Sciences current issue, 2015

We examine in Drosophila a group of ∼35 ionotropic receptors (IRs), the IR20a clade, about which remarkably little is known. Of 28 genes analyzed, GAL4 drivers representing 11 showed expression in the larva. Eight drivers labeled neurons of the pharynx, a taste organ, and three labeled neurons of ...

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Enhanced expression of DNA polymerase eta contributes to cisplatin resistance of ovarian cancer stem cells [Genetics]

07-Apr-2015 | Amit Kumar Srivastava; Chunhua Han; Ran Zhao; Tiantian Cui; Yuntao Dai; Charlene Mao; Weiqiang Zhao; Xiaoli Zhang; J ..., Proceedings of the National Academy of Sciences current issue, 2015

Cancer stem cells (CSCs) with enhanced tumorigenicity and chemoresistance are believed to be responsible for treatment failure and tumor relapse in ovarian cancer patients. However, it is still unclear how CSCs survive DNA-damaging agent treatment. Here, we report an elevated expression of DNA ...

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STAT3-driven transcription depends upon the dimethylation of K49 by EZH2 [Cell Biology]

31-Mar-2015 | Maupali Dasgupta; Josephine Kam Tai Dermawan; Belinda Willard; George R. Stark, Proceedings of the National Academy of Sciences current issue, 2015

Several transcription factors, including p53, NF-κB, and STAT3, are modified by the same enzymes that also modify histones, with important functional consequences. We have identified a previously unrecognized dimethylation of K49 of STAT3 that is crucial for the expression of many IL-6–dependent ...

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Synchronous down-modulation of miR-17 family members is an early causative event in the retinal angiogenic switch [Medical Sciences]

24-Mar-2015 | Diana N. Nunes; Emmanuel Dias-Neto; Marina Cardó-Vila; Julianna K. Edwards; Andrey S. Dobroff; Ricardo J. Giordano; ..., Proceedings of the National Academy of Sciences current issue, 2015

Six members of the microRNA-17 (miR-17) family were mapped to three different chromosomes, although they share the same seed sequence and are predicted to target common genes, among which are those encoding hypoxia-inducible factor-1α (HIF1A) and VEGFA. Here, we evaluated the in vivo expression ...

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Extraordinary diversity of visual opsin genes in dragonflies [Evolution]

17-Mar-2015 | Ryo Futahashi; Ryouka Kawahara-Miki; Michiyo Kinoshita; Kazutoshi Yoshitake; Shunsuke Yajima; Kentaro Arikawa; Takem ..., Proceedings of the National Academy of Sciences current issue, 2015

Dragonflies are colorful and large-eyed animals strongly dependent on color vision. Here we report an extraordinary large number of opsin genes in dragonflies and their characteristic spatiotemporal expression patterns. Exhaustive transcriptomic and genomic surveys of three dragonflies of the ...

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Quorum-sensing Salmonella selectively trigger protein expression within tumors [Engineering]

17-Mar-2015 | Charles A. Swofford; Nele Van Dessel; Neil S. Forbes, Proceedings of the National Academy of Sciences current issue, 2015

Salmonella that secrete anticancer proteins have the potential to eliminate tumors, but nonspecific expression causes damage to healthy tissue. We hypothesize that Salmonella, integrated with a density-dependent switch, would only express proteins in tightly packed colonies within tumors. To test ...

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The RNA binding protein FXR1 is a new driver in the 3q26-29 amplicon and predicts poor prognosis in human cancers [Medical Sciences]

17-Mar-2015 | Jun Qian; Mohamed Hassanein; Megan D. Hoeksema; Bradford K. Harris; Yong Zou; Heidi Chen; Pengcheng Lu; Rosana Eisen ..., Proceedings of the National Academy of Sciences current issue, 2015

Aberrant expression of RNA-binding proteins has profound implications for cellular physiology and the pathogenesis of human diseases such as cancer. We previously identified the Fragile X-Related 1 gene (FXR1) as one amplified candidate driver gene at 3q26-29 in lung squamous cell carcinoma ...

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Retroviral vectors elevate coexpressed protein levels in trans through cap-dependent translation [Microbiology]

17-Mar-2015 | Yongqiang Gou; Hyewon Byun; Adam E. Zook; Gurvani B. Singh; Andrea K. Nash; Mary M. Lozano; Jaquelin P. Dudley, Proceedings of the National Academy of Sciences current issue, 2015

Retroviruses cause immunodeficiency and cancer but also are used as vectors for the expression of heterologous genes. Nevertheless, optimal translation of introduced genes often is not achieved. Here we show that transfection into mammalian cells of lentiviral or gammaretroviral vectors, ...

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