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1,274 Newest Publications in proceedings of the national academy of sciences current issue

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Molecular transitions from papillomavirus infection to cervical precancer and cancer: Role of stromal estrogen receptor signaling [Medical Sciences]

23-Jun-2015 | Johan A. den Boon; Dohun Pyeon; Sophia S. Wang; Mark Horswill; Mark Schiffman; Mark Sherman; Rosemary E. Zuna; Zhish ..., Proceedings of the National Academy of Sciences current issue, 2015

To study the multistep process of cervical cancer development, we analyzed 128 frozen cervical samples spanning normalcy, increasingly severe cervical intraepithelial neoplasia (CIN1– CIN3), and cervical cancer (CxCa) from multiple perspectives, revealing a cascade of progressive changes. ...

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Disregulated expression of the transcription factor ThPOK during T-cell development leads to high incidence of T-cell lymphomas [Immunology and Inflammation]

23-Jun-2015 | Hyung-Ok Lee; Xiao He; Jayati Mookerjee-Basu; Dai Zhongping; Xiang Hua; Emmanuelle Nicolas; Maria Luisa Sulis; Adolf ..., Proceedings of the National Academy of Sciences current issue, 2015

The transcription factor T-helper-inducing POZ/Krueppel-like factor (ThPOK, encoded by the Zbtb7b gene) plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. Here we show that mice expressing a constitutive T-cell–specific ThPOK ...

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Oxytocin modulates fMRI responses to facial expression in macaques [Neuroscience]

16-Jun-2015 | Ning Liu; Fadila Hadj-Bouziane; Katherine B. Jones; Janita N. Turchi; Bruno B. Averbeck; Leslie G. Ungerleider, Proceedings of the National Academy of Sciences current issue, 2015

Increasing evidence has shown that oxytocin (OT), a mammalian hormone, modifies the way social stimuli are perceived and the way they affect behavior. Thus, OT may serve as a treatment for psychiatric disorders, many of which are characterized by dysfunctional social behavior. To explore the ...

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Two-level inhibition of galK expression by Spot 42: Degradation of mRNA mK2 and enhanced transcription termination before the galK gene [Microbiology]

16-Jun-2015 | Xun Wang; Sang Chun Ji; Heung Jin Jeon; Yonho Lee; Heon M. Lim, Proceedings of the National Academy of Sciences current issue, 2015

The Escherichia coli gal operon has the structure Pgal-galE-galT-galK-galM. During early log growth, a gradient in gene expression, named type 2 polarity, is established, as follows: galE > galT > galK > galM. However, during late-log growth, type 1 polarity is established in which galK is ...

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Human ortholog of Drosophila Melted impedes SMAD2 release from TGF-{beta} receptor I to inhibit TGF-{beta} signaling [Cell Biology]

09-Jun-2015 | Premalatha Shathasivam; Alexandra Kollara; Maurice J. Ringuette; Carl Virtanen; Jeffrey L. Wrana; Theodore J. Brown, Proceedings of the National Academy of Sciences current issue, 2015

Drosophila melted encodes a pleckstrin homology (PH) domain-containing protein that enables normal tissue growth, metabolism, and photoreceptor differentiation by modulating Forkhead box O (FOXO), target of rapamycin, and Hippo signaling pathways. Ventricular zone expressed PH domain-containing 1 ...

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Water-soluble chlorophyll protein is involved in herbivore resistance activation during greening of Arabidopsis thaliana [Plant Biology]

09-Jun-2015 | Edouard Boex-Fontvieille; Sachin Rustgi; Diter von Wettstein; Steffen Reinbothe; Christiane Reinbothe, Proceedings of the National Academy of Sciences current issue, 2015

Water-soluble chlorophyll proteins (WSCPs) constitute a small family of unusual chlorophyll (Chl)-binding proteins that possess a Kunitz-type protease inhibitor domain. In Arabidopsis thaliana, a WSCP has been identified, named AtWSCP, that forms complexes with Chl and the Chl precursor ...

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Spatiotemporal expression and transcriptional perturbations by long noncoding RNAs in the mouse brain [Colloquium Paper]

02-Jun-2015 | Loyal A. Goff; Abigail F. Groff; Martin Sauvageau; Zachary Trayes-Gibson; Diana B. Sanchez-Gomez; Michael Morse; Rya ..., Proceedings of the National Academy of Sciences current issue, 2015

Long noncoding RNAs (lncRNAs) have been implicated in numerous cellular processes including brain development. However, the in vivo expression dynamics and molecular pathways regulated by these loci are not well understood. Here, we leveraged a cohort of 13 lncRNA-null mutant mouse models to ...

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Monoallelic expression of the human FOXP2 speech gene [Colloquium Paper]

02-Jun-2015 | Abidemi A. Adegbola; Gerald F. Cox; Elizabeth M. Bradshaw; David A. Hafler; Alexander Gimelbrant; Andrew Chess, Proceedings of the National Academy of Sciences current issue, 2015

The recent descriptions of widespread random monoallelic expression (RMAE) of genes distributed throughout the autosomal genome indicate that there are more genes subject to RMAE on autosomes than the number of genes on the X chromosome where X-inactivation dictates RMAE of X-linked genes. ...

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Th17 cells give rise to Th1 cells that are required for the pathogenesis of colitis [Immunology and Inflammation]

02-Jun-2015 | Stacey N. Harbour; Craig L. Maynard; Carlene L. Zindl; Trenton R. Schoeb; Casey T. Weaver, Proceedings of the National Academy of Sciences current issue, 2015

Th17 cells reactive to the enteric microbiota are central to the pathogenesis of certain types of inflammatory bowel disease. However, Th17 cells display substantial developmental plasticity, such that some progeny of Th17 cell precursors retain a predominantly IL-17A+ phenotype, whereas others ...

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Optimized tools for multicolor stochastic labeling reveal diverse stereotyped cell arrangements in the fly visual system [Neuroscience]

02-Jun-2015 | Aljoscha Nern; Barret D. Pfeiffer; Gerald M. Rubin, Proceedings of the National Academy of Sciences current issue, 2015

We describe the development and application of methods for high-throughput neuroanatomy in Drosophila using light microscopy. These tools enable efficient multicolor stochastic labeling of neurons at both low and high densities. Expression of multiple membrane-targeted and distinct epitope-tagged ...

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