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1,213 Newest Publications in proceedings of the national academy of sciences current issue

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Distinct roles of FKF1, GIGANTEA, and ZEITLUPE proteins in the regulation of CONSTANS stability in Arabidopsis photoperiodic flowering [Plant Biology]

09-12-2014 | Young Hun Song; Daniel A. Estrada; Richard S. Johnson; Somi K. Kim; Sang Yeol Lee; Michael J. MacCoss; Takato Imaizumi, Proceedings of the National Academy of Sciences current issue, 2014

Many plants measure changes in day length to synchronize their flowering time with appropriate seasons for maximum reproductive success. In Arabidopsis, the day-length–dependent regulation of CONSTANS (CO) protein stability is crucial to induce FLOWERING LOCUS T (FT) expression for flowering in ...

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Functionally distinct ERAP1 allotype combinations distinguish individuals with Ankylosing Spondylitis [Immunology and Inflammation]

09-12-2014 | Emma Reeves; Alexandra Colebatch-Bourn; Tim Elliott; Christopher J. Edwards; Edward James, Proceedings of the National Academy of Sciences current issue, 2014

For more than 40 y, expression of HLA-B27 has been strongly associated with the chronic inflammatory disease Ankylosing Spondylitis (AS); however, the mechanisms underlying this association are still unknown. Single nucleotide polymorphisms within the aminopeptidase endoplasmic reticulum ...

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Wnts produced by Osterix-expressing osteolineage cells regulate their proliferation and differentiation [Developmental Biology]

09-12-2014 | Si Hui Tan; Kshemendra Senarath-Yapa; Michael T. Chung; Michael T. Longaker; Joy Y. Wu; Roeland Nusse, Proceedings of the National Academy of Sciences current issue, 2014

Wnt signaling is a critical regulator of bone development, but the identity and role of the Wnt-producing cells are still unclear. We addressed these questions through in situ hybridization, lineage tracing, and genetic experiments. First, we surveyed the expression of all 19 Wnt genes and Wnt ...

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Topoisomerase 1 inhibition reversibly impairs synaptic function [Neuroscience]

02-12-2014 | Angela M. Mabb; Paul H. M. Kullmann; Margaret A. Twomey; Jayalakshmi Miriyala; Benjamin D. Philpot; Mark J. Zylka, Proceedings of the National Academy of Sciences current issue, 2014

Topotecan is a topoisomerase 1 (TOP1) inhibitor that is used to treat various forms of cancer. We recently found that topotecan reduces the expression of multiple long genes, including many neuronal genes linked to synapses and autism. However, whether topotecan alters synaptic protein levels and ...

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Comparison of the transcriptional landscapes between human and mouse tissues [Genetics]

02-12-2014 | Shin Lin; Yiing Lin; Joseph R. Nery; Mark A. Urich; Alessandra Breschi; Carrie A. Davis; Alexander Dobin; Christophe ..., Proceedings of the National Academy of Sciences current issue, 2014

Although the similarities between humans and mice are typically highlighted, morphologically and genetically, there are many differences. To better understand these two species on a molecular level, we performed a comparison of the expression profiles of 15 tissues by deep RNA sequencing and ...

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Neural precursor-specific expression of multiple Drosophila genes is driven by dual enhancer modules with overlapping function [Developmental Biology]

02-12-2014 | Steven W. Miller; Mark Rebeiz; Jenny E. Atanasov; James W. Posakony, Proceedings of the National Academy of Sciences current issue, 2014

Transcriptional cis-regulatory modules (CRMs), or enhancers, are responsible for directing gene expression in specific territories and cell types during development. In some instances, the same gene may be served by two or more enhancers with similar specificities. Here we show that the ...

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Oncogenic activity of the regulatory subunit p85{beta} of phosphatidylinositol 3-kinase (PI3K) [Medical Sciences]

25-11-2014 | Yoshihiro Ito; Jonathan R. Hart; Lynn Ueno; Peter K. Vogt, Proceedings of the National Academy of Sciences current issue, 2014

Expression of the regulatory subunit p85β of PI3K induces oncogenic transformation of primary avian fibroblasts. The transformed cells proliferate at an increased rate compared with nontransformed controls and show elevated levels of PI3K signaling. The oncogenic activity of p85β requires an ...

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The ecology of religious beliefs [Social Sciences]

25-11-2014 | Carlos A. Botero; Beth Gardner; Kathryn R. Kirby; Joseph Bulbulia; Michael C. Gavin; Russell D. Gray, Proceedings of the National Academy of Sciences current issue, 2014

Although ecological forces are known to shape the expression of sociality across a broad range of biological taxa, their role in shaping human behavior is currently disputed. Both comparative and experimental evidence indicate that beliefs in moralizing high gods promote cooperation among humans, ...

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Follicle-stimulating hormone regulates expression and activity of epidermal growth factor receptor in the murine ovarian follicle [Developmental Biology]

25-11-2014 | Stephany El-Hayek; Isabelle Demeestere; Hugh J. Clarke, Proceedings of the National Academy of Sciences current issue, 2014

Fertility depends on the precise coordination of multiple events within the ovarian follicle to ensure ovulation of a fertilizable egg. FSH promotes late follicular development, including expression of luteinizing hormone (LH) receptor by the granulosa cells. Expression of its receptor permits ...

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Transcriptional program of Kpna2/Importin-{alpha}2 regulates cellular differentiation-coupled circadian clock development in mammalian cells [Developmental Biology]

25-11-2014 | Yasuhiro Umemura; Nobuya Koike; Tsuguhiro Matsumoto; Seung-Hee Yoo; Zheng Chen; Noriko Yasuhara; Joseph S. Takahashi ..., Proceedings of the National Academy of Sciences current issue, 2014

The circadian clock in mammalian cells is cell-autonomously generated during the cellular differentiation process, but the underlying mechanisms are not understood. Here we show that perturbation of the transcriptional program by constitutive expression of transcription factor c-Myc and DNA ...

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