My watch list
my.chemeurope.com  
Login  

1,261 Newest Publications in proceedings of the national academy of sciences current issue

rss
matching the following criteria

Multiple functional variants in long-range enhancer elements contribute to the risk of SNP rs965513 in thyroid cancer [Genetics]

12-May-2015 | Huiling He; Wei Li; Sandya Liyanarachchi; Mukund Srinivas; Yanqiang Wang; Keiko Akagi; Yao Wang; Dayong Wu; Qianben ..., Proceedings of the National Academy of Sciences current issue, 2015

The [A] allele of SNP rs965513 in 9q22 has been consistently shown to be highly associated with increased papillary thyroid cancer (PTC) risk with an odds ratio of ∼1.8 as determined by genome-wide association studies, yet the molecular mechanisms remain poorly understood. Previously, we noted ...

more

Functional reconstitution of Drosophila melanogaster NMJ glutamate receptors [Neuroscience]

12-May-2015 | Tae Hee Han; Poorva Dharkar; Mark L. Mayer; Mihaela Serpe, Proceedings of the National Academy of Sciences current issue, 2015

The Drosophila larval neuromuscular junction (NMJ), at which glutamate acts as the excitatory neurotransmitter, is a widely used model for genetic analysis of synapse function and development. Despite decades of study, the inability to reconstitute NMJ glutamate receptor function using ...

more

Genetic differences and aberrant methylation in the apelin system predict the risk of high-altitude pulmonary edema [Genetics]

12-May-2015 | Aastha Mishra; Samantha Kohli; Sanchi Dua; Tashi Thinlas; Ghulam Mohammad; M. A. Qadar Pasha, Proceedings of the National Academy of Sciences current issue, 2015

Hypoxia-inducible factor stimulates the expression of apelin, a potent vasodilator, in response to reduced blood arterial oxygen saturation. However, aberrations in the apelin system impair pulmonary vascular function, potentially resulting in the development of high-altitude (HA)-related ...

more

Low TGF{beta}1 expression prevents and high expression exacerbates diabetic nephropathy in mice [Medical Sciences]

05-May-2015 | Catherine K. Hathaway; Adil M. H. Gasim; Ruriko Grant; Albert S. Chang; Hyung-Suk Kim; Victoria J. Madden; C. Robert ..., Proceedings of the National Academy of Sciences current issue, 2015

Nephropathy develops in many but not all patients with long-standing type 1 diabetes. Substantial efforts to identify genotypic differences explaining this differential susceptibility have been made, with limited success. Here, we show that the expression of the transforming growth factor β1 gene ...

more

Cadherin-related family member 3, a childhood asthma susceptibility gene product, mediates rhinovirus C binding and replication [Microbiology]

28-Apr-2015 | Yury A. Bochkov; Kelly Watters; Shamaila Ashraf; Theodor F. Griggs; Mark K. Devries; Daniel J. Jackson; Ann C. Palme ..., Proceedings of the National Academy of Sciences current issue, 2015

Members of rhinovirus C (RV-C) species are more likely to cause wheezing illnesses and asthma exacerbations compared with other rhinoviruses. The cellular receptor for these viruses was heretofore unknown. We report here that expression of human cadherin-related family member 3 (CDHR3) enables ...

more

Increased size and cellularity of advanced atherosclerotic lesions in mice with endothelial overexpression of the human TRPC3 channel [Medical Sciences]

28-Apr-2015 | Kathryn B. Smedlund; Lutz Birnbaumer; Guillermo Vazquez, Proceedings of the National Academy of Sciences current issue, 2015

In previous in vitro studies, we showed that Transient Receptor Potential Canonical 3 (TRPC3), a calcium-permeable, nonselective cation channel endowed with high constitutive function, is an obligatory component of the inflammatory signaling that controls expression of the vascular cell adhesion ...

more

Reply to Wilkinson: Minor role of programmed methylation and demethylation in mammalian development [Biological Sciences]

28-Apr-2015 | Timothy H. Bestor; John R. Edwards; Mathieu Boulard, Proceedings of the National Academy of Sciences current issue, 2015

Wilkinson (1) does not dispute any of our (2) main claims: that CpG-dense promoters are unmethylated in all tissues and CpG-poor promoters are variably methylated and undergo transcription factor-induced demethylation after activation; that global genome demethylation in cells and tissues does ...

more

Induced transcription and stability of CELF2 mRNA drives widespread alternative splicing during T-cell signaling [Biochemistry]

28-Apr-2015 | Michael J. Mallory; Samuel J. Allon; Jinsong Qiu; Matthew R. Gazzara; Iulia Tapescu; Nicole M. Martinez; Xiang-Dong ..., Proceedings of the National Academy of Sciences current issue, 2015

Studies in several cell types have highlighted dramatic and diverse changes in mRNA processing that occur upon cellular stimulation. However, the mechanisms and pathways that lead to regulated changes in mRNA processing remain poorly understood. Here we demonstrate that expression of the splicing ...

more

Endothelin-1 critically influences cardiac function via superoxide-MMP9 cascade [Medical Sciences]

21-Apr-2015 | Catherine K. Hathaway; Ruriko Grant; John R. Hagaman; Sylvia Hiller; Feng Li; Longquan Xu; Albert S. Chang; Victoria ..., Proceedings of the National Academy of Sciences current issue, 2015

We have generated low-expressing and high-expressing endothelin-1 genes (L and H) and have bred mice with four levels of expression: L/L, ∼20%; L/+, ∼65%; +/+ (wild type), 100%; and H/+, ∼350%. The hypomorphic L allele can be spatiotemporally switched to the hypermorphic H allele by Cre-loxP ...

more

PLZF expression maps the early stages of ILC1 lineage development [Immunology and Inflammation]

21-Apr-2015 | Michael G. Constantinides; Herman Gudjonson; Benjamin D. McDonald; Isabel E. Ishizuka; Philip A. Verhoef; Aaron R. D ..., Proceedings of the National Academy of Sciences current issue, 2015

Among the variety of tissue-resident NK-like populations recently distinguished from recirculating classical NK (cNK) cells, liver innate lymphoid cells (ILC) type 1 (ILC1s) have been shown to represent a distinct lineage that originates from a novel promyelocytic leukaemia zinc finger ...

more

Page 1 From 127
Subscribe to e-mail updates relating to your search

You will receive via e-mail the latest search results matching your search criteria. This service is free of charge and can be cancelled at any time.

Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE