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1,283 Newest Publications in proceedings of the national academy of sciences current issue

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Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart [Physiology]

21-Jul-2015 | Tyler P. Rasmussen; Yuejin Wu; Mei-ling A. Joiner; Olha M. Koval; Nicholas R. Wilson; Elizabeth D. Luczak; Qinchuan ..., Proceedings of the National Academy of Sciences current issue, 2015

Myocardial mitochondrial Ca2+ entry enables physiological stress responses but in excess promotes injury and death. However, tissue-specific in vivo systems for testing the role of mitochondrial Ca2+ are lacking. We developed a mouse model with myocardial delimited transgenic expression of a ...

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Long noncoding RNA derived from CD244 signaling epigenetically controls CD8+ T-cell immune responses in tuberculosis infection [Immunology and Inflammation]

21-Jul-2015 | Yang Wang; Huiling Zhong; Xiaodan Xie; Crystal Y. Chen; Dan Huang; Ling Shen; Hui Zhang; Zheng W. Chen; Gucheng Zeng, Proceedings of the National Academy of Sciences current issue, 2015

Molecular mechanisms for T-cell immune responses modulated by T cell-inhibitory molecules during tuberculosis (TB) infection remain unclear. Here, we show that active human TB infection up-regulates CD244 and CD244 signaling-associated molecules in CD8+ T cells and that blockade of CD244 ...

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Metaanalysis of flawed expression profiling data leading to erroneous Parkinson's biomarker identification [Biological Sciences]

14-Jul-2015 | Lilah Toker; Paul Pavlidis, Proceedings of the National Academy of Sciences current issue, 2015

Santiago and Potashkin (1) propose that two RNAs in blood, hepatocyte nuclear factor 4 alpha (HNF4A) and polypyrimidine tract binding protein 1 (PTBP1), might be clinically useful biomarkers for diagnosing and tracking the progression of Parkinson’s disease (PD), even speculating that they are ...

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Structural asymmetry in a conserved signaling system that regulates division, replication, and virulence of an intracellular pathogen [Microbiology]

14-Jul-2015 | Jonathan W. Willett; Julien Herrou; Ariane Briegel; Grant Rotskoff; Sean Crosson, Proceedings of the National Academy of Sciences current issue, 2015

We have functionally and structurally defined an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival of the global zoonotic pathogen Brucella abortus. Our study delineates phosphoryl transfer through this molecular pathway, ...

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Structural basis for the activation of the C. elegans noncanonical cytoplasmic poly(A)-polymerase GLD-2 by GLD-3 [Biochemistry]

14-Jul-2015 | Katharina Nakel; Fabien Bonneau; Christian R. Eckmann; Elena Conti, Proceedings of the National Academy of Sciences current issue, 2015

The Caenorhabditis elegans germ-line development defective (GLD)-2–GLD-3 complex up-regulates the expression of genes required for meiotic progression. GLD-2–GLD-3 acts by extending the short poly(A) tail of germ-line–specific mRNAs, switching them from a dormant state into a translationally ...

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Pre-TCR ligand binding impacts thymocyte development before {alpha}{beta}TCR expression [Immunology and Inflammation]

07-Jul-2015 | Robert J. Mallis; Ke Bai; Haribabu Arthanari; Rebecca E. Hussey; Maris Handley; Zhenhai Li; Loice Chingozha; Jonatha ..., Proceedings of the National Academy of Sciences current issue, 2015

Adaptive cellular immunity requires accurate self- vs. nonself-discrimination to protect against infections and tumorous transformations while at the same time excluding autoimmunity. This vital capability is programmed in the thymus through selection of αβT-cell receptors (αβTCRs) recognizing ...

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Cooperative strings and glassy interfaces [Physics]

07-Jul-2015 | Thomas Salez; Justin Salez; Kari Dalnoki-Veress; Elie Raphaël; James A. Forrest, Proceedings of the National Academy of Sciences current issue, 2015

We introduce a minimal theory of glass formation based on the ideas of molecular crowding and resultant string-like cooperative rearrangement, and address the effects of free interfaces. In the bulk case, we obtain a scaling expression for the number of particles taking part in cooperative ...

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Genetic and epigenetic architecture of sex-biased expression in the jewel wasps Nasonia vitripennis and giraulti [Genetics]

07-Jul-2015 | Xu Wang; John H. Werren; Andrew G. Clark, Proceedings of the National Academy of Sciences current issue, 2015

There is extraordinary diversity in sexual dimorphism (SD) among animals, but little is known about its epigenetic basis. To study the epigenetic architecture of SD in a haplodiploid system, we performed RNA-seq and whole-genome bisulfite sequencing of adult females and males from two closely ...

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Deregulation of the Hippo pathway in soft-tissue sarcoma promotes FOXM1 expression and tumorigenesis [Medical Sciences]

30-Jun-2015 | T. S. Karin Eisinger-Mathason; Vera Mucaj; Kevin M. Biju; Michael S. Nakazawa; Mercy Gohil; Timothy P. Cash; Sam S. ..., Proceedings of the National Academy of Sciences current issue, 2015

Genetic aberrations responsible for soft-tissue sarcoma formation in adults are largely unknown, with targeted therapies sorely needed for this complex and heterogeneous family of diseases. Here we report that that the Hippo pathway is deregulated in many soft-tissue sarcomas, resulting in ...

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Molecular transitions from papillomavirus infection to cervical precancer and cancer: Role of stromal estrogen receptor signaling [Medical Sciences]

23-Jun-2015 | Johan A. den Boon; Dohun Pyeon; Sophia S. Wang; Mark Horswill; Mark Schiffman; Mark Sherman; Rosemary E. Zuna; Zhish ..., Proceedings of the National Academy of Sciences current issue, 2015

To study the multistep process of cervical cancer development, we analyzed 128 frozen cervical samples spanning normalcy, increasingly severe cervical intraepithelial neoplasia (CIN1– CIN3), and cervical cancer (CxCa) from multiple perspectives, revealing a cascade of progressive changes. ...

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