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1,218 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

Expression and prognostic impact of lncRNAs in acute myeloid leukemia [Medical Sciences]

30-Dec-2014 | Ramiro Garzon; Stefano Volinia; Dimitrios Papaioannou; Deedra Nicolet; Jessica Kohlschmidt; Pearlly S. Yan; Krzyszto ..., Proceedings of the National Academy of Sciences current issue, 2014

Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides, located within the intergenic stretches or overlapping antisense transcripts of protein coding genes. LncRNAs are involved in numerous biological roles including imprinting, epigenetic regulation, apoptosis, and cell ...

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Mice deficient in Rbm38, a target of the p53 family, are susceptible to accelerated aging and spontaneous tumors [Cell Biology]

30-Dec-2014 | Jin Zhang; Enshun Xu; Cong Ren; Wensheng Yan; Min Zhang; Mingyi Chen; Robert D. Cardiff; Denise M. Imai; Erik Wisner ..., Proceedings of the National Academy of Sciences current issue, 2014

RNA-binding motif protein 38 (Rbm38), also called RNPC1 [RNA-binding region (RNP1, RRM) containing 1], is a target of the p53 family and modulates p53 expression via mRNA translation. To investigate the biological function of Rbm38 in vivo, we generated an Rbm38-null mouse model. We showed that ...

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STAT3 promotes survival of mutant photoreceptors in inherited photoreceptor degeneration models [Neuroscience]

30-Dec-2014 | Ke Jiang; Katherine L. Wright; Ping Zhu; Michael J. Szego; Alexa N. Bramall; William W. Hauswirth; Qiuhong Li; Sean ..., Proceedings of the National Academy of Sciences current issue, 2014

Inherited photoreceptor degenerations (IPDs), a group of incurable progressive blinding diseases, are caused by mutations in more than 200 genes, but little is known about the molecular pathogenesis of photoreceptor (PR) death. Increased retinal expression of STAT3 has been observed in response ...

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Restoration of visual function by expression of a light-gated mammalian ion channel in retinal ganglion cells or ON-bipolar cells [Neuroscience]

23-Dec-2014 | Benjamin M. Gaub; Michael H. Berry; Amy E. Holt; Andreas Reiner; Michael A. Kienzler; Natalia Dolgova; Sergei Nikono ..., Proceedings of the National Academy of Sciences current issue, 2014

Most inherited forms of blindness are caused by mutations that lead to photoreceptor cell death but spare second- and third-order retinal neurons. Expression of the light-gated excitatory mammalian ion channel light-gated ionotropic glutamate receptor (LiGluR) in retinal ganglion cells (RGCs) of ...

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Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells [Medical Sciences]

16-Dec-2014 | Debangshu Samanta; Daniele M. Gilkes; Pallavi Chaturvedi; Lisha Xiang; Gregg L. Semenza, Proceedings of the National Academy of Sciences current issue, 2014

Triple negative breast cancers (TNBCs) are defined by the lack of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 expression, and are treated with cytotoxic chemotherapy such as paclitaxel or gemcitabine, with a durable response rate of less than ...

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Distinct roles of FKF1, GIGANTEA, and ZEITLUPE proteins in the regulation of CONSTANS stability in Arabidopsis photoperiodic flowering [Plant Biology]

09-Dec-2014 | Young Hun Song; Daniel A. Estrada; Richard S. Johnson; Somi K. Kim; Sang Yeol Lee; Michael J. MacCoss; Takato Imaizumi, Proceedings of the National Academy of Sciences current issue, 2014

Many plants measure changes in day length to synchronize their flowering time with appropriate seasons for maximum reproductive success. In Arabidopsis, the day-length–dependent regulation of CONSTANS (CO) protein stability is crucial to induce FLOWERING LOCUS T (FT) expression for flowering in ...

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Functionally distinct ERAP1 allotype combinations distinguish individuals with Ankylosing Spondylitis [Immunology and Inflammation]

09-Dec-2014 | Emma Reeves; Alexandra Colebatch-Bourn; Tim Elliott; Christopher J. Edwards; Edward James, Proceedings of the National Academy of Sciences current issue, 2014

For more than 40 y, expression of HLA-B27 has been strongly associated with the chronic inflammatory disease Ankylosing Spondylitis (AS); however, the mechanisms underlying this association are still unknown. Single nucleotide polymorphisms within the aminopeptidase endoplasmic reticulum ...

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Wnts produced by Osterix-expressing osteolineage cells regulate their proliferation and differentiation [Developmental Biology]

09-Dec-2014 | Si Hui Tan; Kshemendra Senarath-Yapa; Michael T. Chung; Michael T. Longaker; Joy Y. Wu; Roeland Nusse, Proceedings of the National Academy of Sciences current issue, 2014

Wnt signaling is a critical regulator of bone development, but the identity and role of the Wnt-producing cells are still unclear. We addressed these questions through in situ hybridization, lineage tracing, and genetic experiments. First, we surveyed the expression of all 19 Wnt genes and Wnt ...

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Topoisomerase 1 inhibition reversibly impairs synaptic function [Neuroscience]

02-Dec-2014 | Angela M. Mabb; Paul H. M. Kullmann; Margaret A. Twomey; Jayalakshmi Miriyala; Benjamin D. Philpot; Mark J. Zylka, Proceedings of the National Academy of Sciences current issue, 2014

Topotecan is a topoisomerase 1 (TOP1) inhibitor that is used to treat various forms of cancer. We recently found that topotecan reduces the expression of multiple long genes, including many neuronal genes linked to synapses and autism. However, whether topotecan alters synaptic protein levels and ...

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Comparison of the transcriptional landscapes between human and mouse tissues [Genetics]

02-Dec-2014 | Shin Lin; Yiing Lin; Joseph R. Nery; Mark A. Urich; Alessandra Breschi; Carrie A. Davis; Alexander Dobin; Christophe ..., Proceedings of the National Academy of Sciences current issue, 2014

Although the similarities between humans and mice are typically highlighted, morphologically and genetically, there are many differences. To better understand these two species on a molecular level, we performed a comparison of the expression profiles of 15 tissues by deep RNA sequencing and ...

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