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1,195 Newest Publications in proceedings of the national academy of sciences current issue

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Reply to Leithner et al.: Focus on phopshoenolpyruvate carboxykinase (PEPCK): A target of the p53-SIRT6-FoxO1 axis [Biological Sciences]

21-10-2014 | Zhiming Li; Wei-Guo Zhu, Proceedings of the National Academy of Sciences current issue, 2014

Cancer metabolism has drawn widespread attention since the unique metabolic properties of cancer cells were characterized. We found that p53, a potent tumor suppressor, down-regulates the expression of phopshoenolpyruvate carboxykinase (PEPCK, PCK1) in coordination with histone deacetylase ...

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CHD8 regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors [Genetics]

21-10-2014 | Aarathi Sugathan; Marta Biagioli; Christelle Golzio; Serkan Erdin; Ian Blumenthal; Poornima Manavalan; Ashok Ragaven ..., Proceedings of the National Academy of Sciences current issue, 2014

Truncating mutations of chromodomain helicase DNA-binding protein 8 (CHD8), and of many other genes with diverse functions, are strong-effect risk factors for autism spectrum disorder (ASD), suggesting multiple mechanisms of pathogenesis. We explored the transcriptional networks that CHD8 ...

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Netrin-4 regulates thalamocortical axon branching in an activity-dependent fashion [Neuroscience]

21-10-2014 | Yasufumi Hayano; Kensuke Sasaki; Nami Ohmura; Makoto Takemoto; Yurie Maeda; Toshihide Yamashita; Yoshio Hata; Kazuhi ..., Proceedings of the National Academy of Sciences current issue, 2014

Axon branching is remodeled by sensory-evoked and spontaneous neuronal activity. However, the underlying molecular mechanism is largely unknown. Here, we demonstrate that the netrin family member netrin-4 (NTN4) contributes to activity-dependent thalamocortical (TC) axon branching. In the ...

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Modulation of age-related insulin sensitivity by VEGF-dependent vascular plasticity in adipose tissues [Medical Sciences]

14-10-2014 | Jennifer Honek; Takahiro Seki; Hideki Iwamoto; Carina Fischer; Jingrong Li; Sharon Lim; Nilesh J. Samani; Jingwu Zan ..., Proceedings of the National Academy of Sciences current issue, 2014

Mechanisms underlying age-related obesity and insulin resistance are generally unknown. Here, we report age-related adipose vascular changes markedly modulated fat mass, adipocyte functions, blood lipid composition, and insulin sensitivity. Notably, VEGF expression levels in various white adipose ...

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Tissue injury and hypoxia promote malignant progression of prostate cancer by inducing CXCL13 expression in tumor myofibroblasts [Cell Biology]

14-10-2014 | Massimo Ammirante; Shabnam Shalapour; Youngjin Kang; Christina A. M. Jamieson; Michael Karin, Proceedings of the National Academy of Sciences current issue, 2014

Prostate cancer (PC) is a slowly progressing malignancy that often responds to androgen ablation or chemotherapy by becoming more aggressive, acquiring a neuroendocrine phenotype, and undergoing metastatic spread. We found that B lymphocytes recruited into regressing androgen-deprived tumors by ...

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Insulin and insulin-like growth factor 1 receptors are required for normal expression of imprinted genes [Medical Sciences]

07-10-2014 | Jeremie Boucher; Marika Charalambous; Kim Zarse; Marcelo A. Mori; Andre Kleinridders; Michael Ristow; Anne C. Fergus ..., Proceedings of the National Academy of Sciences current issue, 2014

In addition to signaling through the classical tyrosine kinase pathway, recent studies indicate that insulin receptors (IRs) and insulin-like growth factor 1 (IGF1) receptors (IGF1Rs) can emit signals in the unoccupied state through some yet-to-be-defined noncanonical pathways. Here we show that ...

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Phospholipase C{delta}1 induces E-cadherin expression and suppresses malignancy in colorectal cancer cells [Medical Sciences]

16-09-2014 | Reiko Satow; Tamaki Hirano; Ryosuke Batori; Tomomi Nakamura; Yumi Murayama; Kiyoko Fukami, Proceedings of the National Academy of Sciences current issue, 2014

Colorectal cancer (CRC) is one of the most common causes of cancer-related deaths worldwide, and Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations in CRC predict the ineffectiveness of EGF receptor-targeted therapy. Previous transcriptional microarray analysis suggests the association ...

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Expression profiling associates blood and brain glucocorticoid receptor signaling with trauma-related individual differences in both sexes [Neuroscience]

16-09-2014 | Nikolaos P. Daskalakis; Hagit Cohen; Guiqing Cai; Joseph D. Buxbaum; Rachel Yehuda, Proceedings of the National Academy of Sciences current issue, 2014

Delineating the molecular basis of individual differences in the stress response is critical to understanding the pathophysiology and treatment of posttraumatic stress disorder (PTSD). In this study, 7 d after predator-scent-stress (PSS) exposure, male and female rats were classified into ...

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Profile of William R. Jacobs, Jr. [Profiles]

16-09-2014 | Ann Griswold, Proceedings of the National Academy of Sciences current issue, 2014

The expression on the young man’s face as he stood by the railing surrounding the zebra enclosure at the Bronx Zoo might have been mistaken for awe at the animals’ magnificent hides or spry gaits. However, as the man reached into the enclosure and scooped a clump of soil and...

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Stat3 promotes IL-10 expression in lupus T cells through trans-activation and chromatin remodeling [Immunology and Inflammation]

16-09-2014 | Christian M. Hedrich; Thomas Rauen; Sokratis A. Apostolidis; Alexandros P. Grammatikos; Noe Rodriguez Rodriguez; Chr ..., Proceedings of the National Academy of Sciences current issue, 2014

The immune-regulatory cytokine IL-10 plays a central role during innate and adaptive immune responses. IL-10 is elevated in the serum and tissues of patients with systemic lupus erythematosus (SLE), an autoimmune disorder characterized by autoantibody production, immune-complex formation, and ...

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