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1,106 Newest Publications in proceedings of the national academy of sciences current issue
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matching the following criteria
Expression of TEX101, regulated by ACE, is essential for the production of fertile mouse spermatozoa [Developmental Biology]
14-05-2013 | Yoshitaka Fujihara; Keizo Tokuhiro; Yuko Muro; Gen Kondoh; Yoshihiko Araki; Masahito Ikawa; Masaru Okabe, Proceedings of the National Academy of Sciences current issue, 2013
Formation of spermatozoa of normal shape, number, and motility is insufficient for the male siring of pups. The spermatozoa must be accompanied by sound fertilizing ability. We found that males with disrupted testis-expressed gene 101 (Tex101) produce normal-looking but ...
Engineering recombinant reoviruses with tandem repeats and a tetravirus 2A-like element for exogenous polypeptide expression [Microbiology]
14-05-2013 | Aleksander A. Demidenko; Joseph N. Blattman; Negin N. Blattman; Philip D. Greenberg; Max L. Nibert, Proceedings of the National Academy of Sciences current issue, 2013
We tested a strategy for engineering recombinant mammalian reoviruses (rMRVs) to express exogenous polypeptides. One important feature is that these rMRVs are designed to propagate autonomously and can therefore be tested in animals as potential vaccine vectors. The strategy has been applied ...
AMPA receptor exchange underlies transient memory destabilization on retrieval [Neuroscience]
14-05-2013 | Ingie Hong; Jeongyeon Kim; Jihye Kim; Sukwon Lee; Hyoung-Gon Ko; Karim Nader; Bong-Kiun Kaang; Richard W. Tsien; Suk ..., Proceedings of the National Academy of Sciences current issue, 2013
A consolidated memory can be transiently destabilized by memory retrieval, after which memories are reconsolidated within a few hours; however, the molecular substrates underlying this destabilization process remain essentially unknown. Here we show that at lateral amygdala synapses, fear ...
IL-15 in tumor microenvironment causes rejection of large established tumors by T cells in a noncognate T cell receptor-dependent manner [Immunology]
14-05-2013 | Rebecca Berlant Liu; Boris Engels; Karin Schreiber; Cezary Ciszewski; Andrea Schietinger; Hans Schreiber; Bana Jabri, Proceedings of the National Academy of Sciences current issue, 2013
A major challenge of cancer immunotherapy is the persistence and outgrowth of subpopulations that lose expression of the target antigen. IL-15 is a potent cytokine that can promote organ-specific autoimmunity when up-regulated on tissue cells. Here we report that T cells eradicated 2-wk-old ...
Imprinted expression of genes and small RNA is associated with localized hypomethylation of the maternal genome in rice endosperm [Plant Biology]
07-05-2013 | Jessica A. Rodrigues; Randy Ruan; Toshiro Nishimura; Manoj K. Sharma; Rita Sharma; Pamela C. Ronald; Robert L. Fisch ..., Proceedings of the National Academy of Sciences current issue, 2013
Arabidopsis thaliana endosperm, a transient tissue that nourishes the embryo, exhibits extensive localized DNA demethylation on maternally inherited chromosomes. Demethylation mediates parent-of-origin–specific (imprinted) gene expression but is apparently unnecessary for the extensive ...
The molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteins [Immunology]
07-05-2013 | Jacinto López-Sagaseta; Charles L. Dulberger; James E. Crooks; Chelsea D. Parks; Adrienne M. Luoma; Amanda McFedries ..., Proceedings of the National Academy of Sciences current issue, 2013
Mucosal-associated invariant T (MAIT) cells are an evolutionarily conserved αβ T-cell lineage that express a semi-invariant T-cell receptor (TCR) restricted to the MHC related-1 (MR1) protein. MAIT cells are dependent upon MR1 expression and exposure to microbes for their development and ...
Accumulation of the FACT complex, as well as histone H3.3, serves as a target marker for somatic hypermutation [Genetics]
07-05-2013 | Masatoshi Aida; Nesreen Hamad; Andre Stanlie; Nasim A. Begum; Tasuku Honjo, Proceedings of the National Academy of Sciences current issue, 2013
Somatic hypermutation (SHM) requires not only the expression of activation-induced cytidine deaminase, but also transcription in the target regions. However, how transcription guides activation-induced cytidine deaminase in targeting SHM to the Ig genes is not fully understood. Here, we found ...
Domain cooperativity in the {beta}1a subunit is essential for dihydropyridine receptor voltage sensing in skeletal muscle [Physiology]
30-04-2013 | Anamika Dayal; Vinayakumar Bhat; Clara Franzini-Armstrong; Manfred Grabner, Proceedings of the National Academy of Sciences current issue, 2013
The dihydropyridine receptor (DHPR) β1a subunit is crucial for enhancement of DHPR triad expression, assembly of DHPRs in tetrads, and elicitation of DHPRα1S charge movement—the three prerequisites of skeletal muscle excitation–contraction coupling. Despite the ability to fully target α1S ...
Deficiency of {beta}-arrestin1 ameliorates collagen-induced arthritis with impaired TH17 cell differentiation [Immunology]
30-04-2013 | Juan Li; Bin Wei; Ao Guo; Chang Liu; Shichao Huang; Fang Du; Wei Fan; Chunde Bao; Gang Pei, Proceedings of the National Academy of Sciences current issue, 2013
Rheumatoid arthritis (RA) is an inflammatory disease in which interleukin 17 (IL-17)-producing T helper 17 (TH17) cells have been critically involved. We show that in patients with RA, the expression of a multifunctional regulator β-arrestin1 was significantly up-regulated in peripheral and ...
Dosage compensation and inverse effects in triple X metafemales of Drosophila [Genetics]
30-04-2013 | Lin Sun; Adam F. Johnson; Ryan C. Donohue; Jilong Li; Jianlin Cheng; James A. Birchler, Proceedings of the National Academy of Sciences current issue, 2013
Dosage compensation, the equalized X chromosome gene expression between males and females in Drosophila, has also been found in triple X metafemales. Inverse dosage effects, produced by genomic imbalance, are believed to account for this modulated expression, but they have not been studied on ...
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