My watch list
my.chemeurope.com  
Login  

967 Newest Publications in proceedings of the national academy of sciences current issue

rss
matching the following criteria

Glucocorticoid-induced tethered transrepression requires SUMOylation of GR and formation of a SUMO-SMRT/NCoR1-HDAC3 repressing complex [Pharmacology]

02-Feb-2016 | Guoqiang Hua; Krishna Priya Ganti; Pierre Chambon, Proceedings of the National Academy of Sciences current issue, 2016

Upon binding of a glucocorticoid (GC), the GC receptor (GR) can exert one of three transcriptional regulatory functions. We recently reported that SUMOylation of the GR at position K293 in humans (K310 in mice) within the N-terminal domain is indispensable for GC-induced evolutionary conserved ...

more

GR SUMOylation and formation of an SUMO-SMRT/NCoR1-HDAC3 repressing complex is mandatory for GC-induced IR nGRE-mediated transrepression [Pharmacology]

02-Feb-2016 | Guoqiang Hua; Laetitia Paulen; Pierre Chambon, Proceedings of the National Academy of Sciences current issue, 2016

Unique among the nuclear receptor superfamily, the glucocorticoid (GC) receptor (GR) can exert three distinct transcriptional regulatory functions on binding of a single natural (cortisol in human and corticosterone in mice) and synthetic [e.g., dexamethasone (Dex)] hormone. The molecular ...

more

Transcription factor 7-like 1 is involved in hypothalamo-pituitary axis development in mice and humans [Developmental Biology]

02-Feb-2016 | Carles Gaston-Massuet; Mark J. McCabe; Valeria Scagliotti; Rodrigo M. Young; Gabriela Carreno; Louise C. Gregory; Su ..., Proceedings of the National Academy of Sciences current issue, 2016

Aberrant embryonic development of the hypothalamus and/or pituitary gland in humans results in congenital hypopituitarism (CH). Transcription factor 7-like 1 (TCF7L1), an important regulator of the WNT/β-catenin signaling pathway, is expressed in the developing forebrain and pituitary gland, but ...

more

A dynamic Asp-Arg interaction is essential for catalysis in microsomal prostaglandin E2 synthase [Biochemistry]

26-Jan-2016 | Joseph S. Brock; Mats Hamberg; Navisraj Balagunaseelan; Michael Goodman; Ralf Morgenstern; Emilia Strandback; Bengt ..., Proceedings of the National Academy of Sciences current issue, 2016

Microsomal prostaglandin E2 synthase type 1 (mPGES-1) is responsible for the formation of the potent lipid mediator prostaglandin E2 under proinflammatory conditions, and this enzyme has received considerable attention as a drug target. Recently, a high-resolution crystal structure of human ...

more

Long-term clinical study and multiscale analysis of in vivo biodegradation mechanism of Mg alloy [Medical Sciences]

19-Jan-2016 | Jee-Wook Lee; Hyung-Seop Han; Kyeong-Jin Han; Jimin Park; Hojeong Jeon; Myoung-Ryul Ok; Hyun-Kwang Seok; Jae-Pyoung ..., Proceedings of the National Academy of Sciences current issue, 2016

There has been a tremendous amount of research in the past decade to optimize the mechanical properties and degradation behavior of the biodegradable Mg alloy for orthopedic implant. Despite the feasibility of degrading implant, the lack of fundamental understanding about biocompatibility and ...

more

Micronucleus formation causes perpetual unilateral chromosome inheritance in mouse embryos [Cell Biology]

19-Jan-2016 | Cayetana Vázquez-Diez; Kazuo Yamagata; Shardul Trivedi; Jenna Haverfield; Greg FitzHarris, Proceedings of the National Academy of Sciences current issue, 2016

Chromosome segregation defects in cancer cells lead to encapsulation of chromosomes in micronuclei (MN), small nucleus-like structures within which dangerous DNA rearrangements termed chromothripsis can occur. Here we uncover a strikingly different consequence of MN formation in preimplantation ...

more

Inhibition of Hif1{alpha} prevents both trauma-induced and genetic heterotopic ossification [Medical Sciences]

19-Jan-2016 | Shailesh Agarwal; Shawn Loder; Cameron Brownley; David Cholok; Laura Mangiavini; John Li; Christopher Breuler; Hsiao ..., Proceedings of the National Academy of Sciences current issue, 2016

Pathologic extraskeletal bone formation, or heterotopic ossification (HO), occurs following mechanical trauma, burns, orthopedic operations, and in patients with hyperactivating mutations of the type I bone morphogenetic protein receptor ACVR1 (Activin type 1 receptor). Extraskeletal bone forms ...

more

SDPR functions as a metastasis suppressor in breast cancer by promoting apoptosis [Cell Biology]

19-Jan-2016 | Sait Ozturk; Panagiotis Papageorgis; Chen Khuan Wong; Arthur W. Lambert; Hamid M. Abdolmaleky; Arunthathi Thiagaling ..., Proceedings of the National Academy of Sciences current issue, 2016

Metastatic dissemination of breast cancer cells represents a significant clinical obstacle to curative therapy. The loss of function of metastasis suppressor genes is a major rate-limiting step in breast cancer progression that prevents the formation of new colonies at distal sites. However, the ...

more

Geometry-induced protein pattern formation [Physics]

19-Jan-2016 | Dominik Thalmeier; Jacob Halatek; Erwin Frey, Proceedings of the National Academy of Sciences current issue, 2016

Protein patterns are known to adapt to cell shape and serve as spatial templates that choreograph downstream processes like cell polarity or cell division. However, how can pattern-forming proteins sense and respond to the geometry of a cell, and what mechanistic principles underlie pattern ...

more

Structure determination of helical filaments by solid-state NMR spectroscopy [Biophysics and Computational Biology]

19-Jan-2016 | Lichun He; Benjamin Bardiaux; Mumdooh Ahmed; Johannes Spehr; Renate König; Heinrich Lünsdorf; Ulfert Rand; Thorsten ..., Proceedings of the National Academy of Sciences current issue, 2016

The controlled formation of filamentous protein complexes plays a crucial role in many biological systems and represents an emerging paradigm in signal transduction. The mitochondrial antiviral signaling protein (MAVS) is a central signal transduction hub in innate immunity that is activated by a ...

more

Page 1 From 97
Subscribe to e-mail updates relating to your search

You will receive via e-mail the latest search results matching your search criteria. This service is free of charge and can be cancelled at any time.

Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE