My watch list
my.chemeurope.com  
Login  

292 Newest Publications in proceedings of the national academy of sciences current issue

rss
matching the following criteria

PRMT5 dimethylates R30 of the p65 subunit to activate NF-{kappa}B [Medical Sciences]

13-08-2013 | Han Wei; Benlian Wang; Masaru Miyagi; Yun She; Banu Gopalan; De-Bin Huang; Gourisankar Ghosh; George R. Stark; Tao Lu, Proceedings of the National Academy of Sciences current issue, 2013

The ubiquitous inducible transcription factor NF-κB plays central roles in immune and inflammatory responses and in tumorigenesis. Complex posttranslational modifications of the p65 subunit (RelA) are a major aspect of the extremely flexible regulation of NF-κB activity. Although phosphorylation, ...

more

Atg29 phosphorylation regulates coordination of the Atg17-Atg31-Atg29 complex with the Atg11 scaffold during autophagy initiation [Cell Biology]

30-07-2013 | Kai Mao; Leon H. Chew; Yuko Inoue-Aono; Heesun Cheong; Usha Nair; Hana Popelka; Calvin K. Yip; Daniel J. Klionsky, Proceedings of the National Academy of Sciences current issue, 2013

Macroautophagy (hereafter autophagy) functions in the nonselective clearance of cytoplasm. This process participates in many aspects of cell physiology, and is conserved in all eukaryotes. Autophagy begins with the organization of the phagophore assembly site (PAS), where most of the ...

more

Activation loop phosphorylation of a protein kinase is a molecular marker of organelle size that dynamically reports flagellar length [Cell Biology]

23-07-2013 | Muqing Cao; Dan Meng; Liang Wang; Shuqing Bei; William J. Snell; Junmin Pan, Proceedings of the National Academy of Sciences current issue, 2013

Specification of organelle size is crucial for cell function, yet we know little about the molecular mechanisms that report and regulate organelle growth and steady-state dimensions. The biflagellated green alga Chlamydomonas requires continuous-length feedback to integrate the multiple events ...

more

Quantitative phosphoproteomics identifies SnRK2 protein kinase substrates and reveals the effectors of abscisic acid action [Plant Biology]

02-07-2013 | Pengcheng Wang; Liang Xue; Giorgia Batelli; Shinyoung Lee; Yueh-Ju Hou; Michael J. Van Oosten; Huiming Zhang; W. And ..., Proceedings of the National Academy of Sciences current issue, 2013

Sucrose nonfermenting 1 (SNF1)-related protein kinase 2s (SnRK2s) are central components of abscisic acid (ABA) signaling pathways. The snrk2.2/2.3/2.6 triple-mutant plants are nearly completely insensitive to ABA, suggesting that most of the molecular actions of ABA are triggered by the ...

more

Phosphorylation of the Bin, Amphiphysin, and RSV161/167 (BAR) domain of ACAP4 regulates membrane tubulation [Cell Biology]

02-07-2013 | Xuannv Zhao; Dongmei Wang; Xing Liu; Lifang Liu; Zhenwei Song; Tongge Zhu; Gregory Adams; Xinjiao Gao; Ruijun Tian; ..., Proceedings of the National Academy of Sciences current issue, 2013

ArfGAP With Coiled-Coil, Ankyrin Repeat And PH Domains 4 (ACAP4) is an ADP-ribosylation factor 6 (ARF6) GTPase-activating protein essential for EGF-elicited cell migration. However, how ACAP4 regulates membrane dynamics and curvature in response to EGF stimulation is unknown. Here, we show that ...

more

Phosphorylation-triggered CUEDC2 degradation promotes UV-induced G1 arrest through APC/CCdh1 regulation [Cell Biology]

02-07-2013 | Wei-Na Zhang; Jie Zhou; Tao Zhou; Ai-Ling Li; Na Wang; Jin-Jing Xu; Yan Chang; Jiang-Hong Man; Xin Pan; Tao Li; Wei- ..., Proceedings of the National Academy of Sciences current issue, 2013

DNA damage triggers cell cycle arrest to provide a time window for DNA repair. Failure of arrest could lead to genomic instability and tumorigenesis. DNA damage-induced G1 arrest is generally achieved by the accumulation of Cyclin-dependent kinase inhibitor 1 (p21). However, p21 is degraded and ...

more

APE2 is required for ATR-Chk1 checkpoint activation in response to oxidative stress [Biochemistry]

25-06-2013 | Jeremy Willis; Yogin Patel; Barry L. Lentz; Shan Yan, Proceedings of the National Academy of Sciences current issue, 2013

The base excision repair pathway is largely responsible for the repair of oxidative stress-induced DNA damage. However, it remains unclear how the DNA damage checkpoint is activated by oxidative stress at the molecular level. Here, we provide evidence showing that hydrogen peroxide (H2O2) ...

more

Essential role for Cdk2 inhibitory phosphorylation during replication stress revealed by a human Cdk2 knockin mutation [Cell Biology]

28-05-2013 | Bridget T. Hughes; Julia Sidorova; Jherek Swanger; Raymond J. Monnat, Jr.; Bruce E. Clurman, Proceedings of the National Academy of Sciences current issue, 2013

Cyclin-dependent kinases (Cdks) coordinate cell division, and their activities are tightly controlled. Phosphorylation of threonine 14 (T14) and tyrosine 15 (Y15) inhibits Cdks and regulates their activities in numerous physiologic contexts. Although the roles of Cdk1 inhibitory phosphorylation ...

more

PRMT5 modulates the metabolic response to fasting signals [Biochemistry]

28-05-2013 | Wen-Wei Tsai; Sherry Niessen; Naomi Goebel; John R. Yates III; Ernesto Guccione; Marc Montminy, Proceedings of the National Academy of Sciences current issue, 2013

Under fasting conditions, increases in circulating glucagon maintain glucose balance by promoting hepatic gluconeogenesis. Triggering of the cAMP pathway stimulates gluconeogenic gene expression through the PKA-mediated phosphorylation of the cAMP response element binding (CREB) protein and via ...

more

Structural basis of the relaxed state of a Ca2+-regulated myosin filament and its evolutionary implications [Cell Biology]

21-05-2013 | John L. Woodhead; Fa-Qing Zhao; Roger Craig, Proceedings of the National Academy of Sciences current issue, 2013

Myosin filaments of muscle are regulated either by phosphorylation of their regulatory light chains or Ca2+ binding to the essential light chains, contributing to on–off switching or modulation of contraction. Phosphorylation-regulated filaments in the relaxed state are characterized by an ...

more

Page 1 From 30
Subscribe to e-mail updates relating to your search

You will receive via e-mail the latest search results matching your search criteria. This service is free of charge and can be cancelled at any time.

Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE