My watch list
my.chemeurope.com  
Login  

673 Newest Publications in proceedings of the national academy of sciences current issue

rss
matching the following criteria

Functional architecture of the Reb1-Ter complex of Schizosaccharomyces pombe [Biochemistry]

19-Apr-2016 | Rahul Jaiswal; Malay Choudhury; Shamsu Zaman; Samarendra Singh; Vishaka Santosh; Deepak Bastia; Carlos R. Escalante, Proceedings of the National Academy of Sciences current issue, 2016

Reb1 of Schizosaccharomyces pombe represents a family of multifunctional proteins that bind to specific terminator sites (Ter) and cause polar termination of transcription catalyzed by RNA polymerase I (pol I) and arrest of replication forks approaching the Ter sites from the opposite direction. ...

more

Host-parasite oscillation dynamics and evolution in a compartmentalized RNA replication system [Biochemistry]

12-Apr-2016 | Yohsuke Bansho; Taro Furubayashi; Norikazu Ichihashi; Tetsuya Yomo, Proceedings of the National Academy of Sciences current issue, 2016

To date, various cellular functions have been reconstituted in vitro such as self-replication systems using DNA, RNA, and proteins. The next important challenges include the reconstitution of the interactive networks of self-replicating species and investigating how such interactions generate ...

more

Structures of E. coli {sigma}S-transcription initiation complexes provide new insights into polymerase mechanism [Biochemistry]

12-Apr-2016 | Bin Liu; Yuhong Zuo; Thomas A. Steitz, Proceedings of the National Academy of Sciences current issue, 2016

In bacteria, multiple σ factors compete to associate with the RNA polymerase (RNAP) core enzyme to form a holoenzyme that is required for promoter recognition. During transcription initiation RNAP remains associated with the upstream promoter DNA via sequence-specific interactions between the σ ...

more

QnAs with Jan Svoboda [QnAs]

12-Apr-2016 | Brian Doctrow, Proceedings of the National Academy of Sciences current issue, 2016

HIV belongs to a family of viruses known as retroviruses. The ability of retroviruses to synthesize DNA using their RNA genome as a template distinguishes them from other viruses. The synthesized DNA can then integrate itself into the genome of an infected cell, becoming what is known as a ...

more

Identification and characterization of influenza variants resistant to a viral endonuclease inhibitor [Pharmacology]

29-Mar-2016 | Min-Suk Song; Gyanendra Kumar; William R. Shadrick; Wei Zhou; Trushar Jeevan; Zhenmei Li; P. Jake Slavish; Thomas P. ..., Proceedings of the National Academy of Sciences current issue, 2016

The influenza endonuclease is an essential subdomain of the viral RNA polymerase. It processes host pre-mRNAs to serve as primers for viral mRNA and is an attractive target for antiinfluenza drug discovery. Compound L-742,001 is a prototypical endonuclease inhibitor, and we found that repeated ...

more

TFE and Spt4/5 open and close the RNA polymerase clamp during the transcription cycle [Biochemistry]

29-Mar-2016 | Sarah Schulz; Andreas Gietl; Katherine Smollett; Philip Tinnefeld; Finn Werner; Dina Grohmann, Proceedings of the National Academy of Sciences current issue, 2016

Transcription is an intrinsically dynamic process and requires the coordinated interplay of RNA polymerases (RNAPs) with nucleic acids and transcription factors. Classical structural biology techniques have revealed detailed snapshots of a subset of conformational states of the RNAP as they exist ...

more

Open complex scrunching before nucleotide addition accounts for the unusual transcription start site of E. coli ribosomal RNA promoters [Biochemistry]

29-Mar-2016 | Jared T. Winkelman; Pete Chandrangsu; Wilma Ross; Richard L. Gourse, Proceedings of the National Academy of Sciences current issue, 2016

Most Escherichia coli promoters initiate transcription with a purine 7 or 8 nt downstream from the –10 hexamer, but some promoters, including the ribosomal RNA promoter rrnB P1, start 9 nt from the –10 element. We identified promoter and RNA polymerase determinants of this noncanonical rrnB P1 ...

more

Use of the Fluidigm C1 platform for RNA sequencing of single mouse pancreatic islet cells [Cell Biology]

22-Mar-2016 | Yurong Xin; Jinrang Kim; Min Ni; Yi Wei; Haruka Okamoto; Joseph Lee; Christina Adler; Katie Cavino; Andrew J. Murphy ..., Proceedings of the National Academy of Sciences current issue, 2016

This study provides an assessment of the Fluidigm C1 platform for RNA sequencing of single mouse pancreatic islet cells. The system combines microfluidic technology and nanoliter-scale reactions. We sequenced 622 cells, allowing identification of 341 islet cells with high-quality gene expression ...

more

EBV noncoding RNA EBER2 interacts with host RNA-binding proteins to regulate viral gene expression [Biochemistry]

22-Mar-2016 | Nara Lee; Therese A. Yario; Jessica S. Gao; Joan A. Steitz, Proceedings of the National Academy of Sciences current issue, 2016

Epstein–Barr virus (EBV) produces a highly abundant noncoding RNA called EBV-encoded RNA 2 (EBER2) that interacts indirectly with the host transcription factor paired box protein 5 (PAX5) to regulate viral latent membrane protein 1/2 (LMP1/2) gene expression as well as EBV lytic replication. To ...

more

Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles [Chemistry]

15-Mar-2016 | Ming Wang; John A. Zuris; Fantao Meng; Holly Rees; Shuo Sun; Pu Deng; Yong Han; Xue Gao; Dimitra Pouli; Qi Wu; Irene ..., Proceedings of the National Academy of Sciences current issue, 2016

A central challenge to the development of protein-based therapeutics is the inefficiency of delivery of protein cargo across the mammalian cell membrane, including escape from endosomes. Here we report that combining bioreducible lipid nanoparticles with negatively supercharged Cre recombinase or ...

more

Page 1 From 68
Subscribe to e-mail updates relating to your search

You will receive via e-mail the latest search results matching your search criteria. This service is free of charge and can be cancelled at any time.

Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE