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560 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

Role of a ribosomal RNA phosphate oxygen during the EF-G-triggered GTP hydrolysis [Chemistry]

19-May-2015 | Miriam Koch; Sara Flür; Christoph Kreutz; Eric Ennifar; Ronald Micura; Norbert Polacek, Proceedings of the National Academy of Sciences current issue, 2015

Elongation factor-catalyzed GTP hydrolysis is a key reaction during the ribosomal elongation cycle. Recent crystal structures of G proteins, such as elongation factor G (EF-G) bound to the ribosome, as well as many biochemical studies, provide evidence that the direct interaction of translational ...

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A {Omega}XaV motif in the Rift Valley fever virus NSs protein is essential for degrading p62, forming nuclear filaments and virulence [Biochemistry]

12-May-2015 | Normand Cyr; Cynthia de la Fuente; Lauriane Lecoq; Irene Guendel; Philippe R. Chabot; Kylene Kehn-Hall; James G. Omi ..., Proceedings of the National Academy of Sciences current issue, 2015

Rift Valley fever virus (RVFV) is a single-stranded RNA virus capable of inducing fatal hemorrhagic fever in humans. A key component of RVFV virulence is its ability to form nuclear filaments through interactions between the viral nonstructural protein NSs and the host general transcription ...

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Cas9-mediated targeting of viral RNA in eukaryotic cells [Microbiology]

12-May-2015 | Aryn A. Price; Timothy R. Sampson; Hannah K. Ratner; Arash Grakoui; David S. Weiss, Proceedings of the National Academy of Sciences current issue, 2015

Clustered, regularly interspaced, short palindromic repeats–CRISPR associated (CRISPR-Cas) systems are prokaryotic RNA-directed endonuclease machineries that act as an adaptive immune system against foreign genetic elements. Using small CRISPR RNAs that provide specificity, Cas proteins recognize ...

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Inactivation of EWS reduces PGC-1{alpha} protein stability and mitochondrial homeostasis [Cell Biology]

12-May-2015 | Jun Hong Park; Hong-Jun Kang; Yun Kyung Lee; Hyeog Kang; Jihyun Kim; Jay H. Chung; Ji Suk Chang; Alexandra C. McPher ..., Proceedings of the National Academy of Sciences current issue, 2015

EWS (Ewing sarcoma) encodes an RNA/ssDNA binding protein that is frequently rearranged in a number of different cancers by chromosomal translocations. Physiologically, EWS has diverse and essential roles in various organ development and cellular processes. In this study, we uncovered a new role ...

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Role for RNA:DNA hybrids in origin-independent replication priming in a eukaryotic system [Genetics]

05-May-2015 | Ruth Stuckey; Néstor García-Rodríguez; Andrés Aguilera; Ralf Erik Wellinger, Proceedings of the National Academy of Sciences current issue, 2015

DNA replication initiates at defined replication origins along eukaryotic chromosomes, ensuring complete genome duplication within a single S-phase. A key feature of replication origins is their ability to control the onset of DNA synthesis mediated by DNA polymerase-α and its intrinsic RNA ...

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Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase [Immunology and Inflammation]

05-May-2015 | Wenjun Hu; Nasim A. Begum; Samiran Mondal; Andre Stanlie; Tasuku Honjo, Proceedings of the National Academy of Sciences current issue, 2015

Activation-induced cytidine deaminase (AID) is essential for antibody class switch recombination (CSR) and somatic hypermutation (SHM). AID originally was postulated to function as an RNA-editing enzyme, based on its strong homology with apolipoprotein B mRNA-editing enzyme, catalytic polypeptide ...

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Microbial community transcriptional networks are conserved in three domains at ocean basin scales [Earth, Atmospheric, and Planetary Sciences]

28-Apr-2015 | Frank O. Aylward; John M. Eppley; Jason M. Smith; Francisco P. Chavez; Christopher A. Scholin; Edward F. DeLong, Proceedings of the National Academy of Sciences current issue, 2015

Planktonic microbial communities in the ocean are typically dominated by several cosmopolitan clades of Bacteria, Archaea, and Eukarya characterized by their ribosomal RNA gene phylogenies and genomic features. Although the environments these communities inhabit range from coastal to open ocean ...

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Stochastic induction of persister cells by HipA through (p)ppGpp-mediated activation of mRNA endonucleases [Microbiology]

21-Apr-2015 | Elsa Germain; Mohammad Roghanian; Kenn Gerdes; Etienne Maisonneuve, Proceedings of the National Academy of Sciences current issue, 2015

The model organism Escherichia coli codes for at least 11 type II toxin–antitoxin (TA) modules, all implicated in bacterial persistence (multidrug tolerance). Ten of these encode messenger RNA endonucleases (mRNases) inhibiting translation by catalytic degradation of mRNA, and the 11th module, ...

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Potential role for snoRNAs in PKR activation during metabolic stress [Biochemistry]

21-Apr-2015 | Osama A. Youssef; Sarah A. Safran; Takahisa Nakamura; David A. Nix; Gökhan S. Hotamisligil; Brenda L. Bass, Proceedings of the National Academy of Sciences current issue, 2015

Protein kinase RNA-activated (PKR) has long been known to be activated by viral double-stranded RNA (dsRNA) as part of the mammalian immune response. However, in mice PKR is also activated by metabolic stress in the absence of viral infection, and this requires a functional kinase domain, as well ...

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Robust and sustained immune activation in human Ebola virus infection [Immunology and Inflammation]

14-Apr-2015 | Judith N. Mandl; Mark B. Feinberg, Proceedings of the National Academy of Sciences current issue, 2015

Ebola viruses (EBOV) are zoonotic infectious agents that are highly pathogenic in humans, causing severe hemorrhagic fever with fatality rates of ∼50–70% (1). This genus of negative single-stranded RNA viruses consists of five known species that are part of the Filoviridae family. The current ...

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