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565 Newest Publications in proceedings of the national academy of sciences current issue

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Evolutionary and phenotypic analysis of live virus isolates suggests arthropod origin of a pathogenic RNA virus family [Evolution]

16-Jun-2015 | Marco Marklewitz; Florian Zirkel; Andreas Kurth; Christian Drosten; Sandra Junglen, Proceedings of the National Academy of Sciences current issue, 2015

The evolutionary origins of arboviruses are unknown because their typical dual host tropism is paraphyletic within viral families. Here we studied one of the most diversified and medically relevant RNA virus families, the Bunyaviridae, in which four of five established genera are transmitted by ...

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hnRNP U protein is required for normal pre-mRNA splicing and postnatal heart development and function [Developmental Biology]

09-Jun-2015 | Junqiang Ye; Nadine Beetz; Sean O’Keeffe; Juan Carlos Tapia; Lindsey Macpherson; Weisheng V. Chen; Rhonda Bassel-Dub ..., Proceedings of the National Academy of Sciences current issue, 2015

We report that mice lacking the heterogeneous nuclear ribonucleoprotein U (hnRNP U) in the heart develop lethal dilated cardiomyopathy and display numerous defects in cardiac pre-mRNA splicing. Mutant hearts have disorganized cardiomyocytes, impaired contractility, and abnormal ...

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Systematic transcriptome analysis reveals tumor-specific isoforms for ovarian cancer diagnosis and therapy [Medical Sciences]

09-Jun-2015 | Christian L. Barrett; Christopher DeBoever; Kristen Jepsen; Cheryl C. Saenz; Dennis A. Carson; Kelly A. Frazer, Proceedings of the National Academy of Sciences current issue, 2015

Tumor-specific molecules are needed across diverse areas of oncology for use in early detection, diagnosis, prognosis and therapy. Large and growing public databases of transcriptome sequencing data (RNA-seq) derived from tumors and normal tissues hold the potential of yielding tumor-specific ...

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The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics [Biophysics and Computational Biology]

09-Jun-2015 | Shana Elbaum-Garfinkle; Younghoon Kim; Krzysztof Szczepaniak; Carlos Chih-Hsiung Chen; Christian R. Eckmann; Sua Myo ..., Proceedings of the National Academy of Sciences current issue, 2015

P granules and other RNA/protein bodies are membrane-less organelles that may assemble by intracellular phase separation, similar to the condensation of water vapor into droplets. However, the molecular driving forces and the nature of the condensed phases remain poorly understood. Here, we show ...

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The messenger RNA decapping and recapping pathway in Trypanosoma [Biochemistry]

02-Jun-2015 | Anna V. Ignatochkina; Yuko Takagi; Yancheng Liu; Kyosuke Nagata; C. Kiong Ho, Proceedings of the National Academy of Sciences current issue, 2015

The 5′ terminus of trypanosome mRNA is protected by a hypermethylated cap 4 derived from spliced leader (SL) RNA. Trypanosoma brucei nuclear capping enzyme with cap guanylyltransferase and methyltransferase activities (TbCgm1) modifies the 5′-diphosphate RNA (ppRNA) end to generate an m7G SL RNA ...

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Role of a ribosomal RNA phosphate oxygen during the EF-G-triggered GTP hydrolysis [Chemistry]

19-May-2015 | Miriam Koch; Sara Flür; Christoph Kreutz; Eric Ennifar; Ronald Micura; Norbert Polacek, Proceedings of the National Academy of Sciences current issue, 2015

Elongation factor-catalyzed GTP hydrolysis is a key reaction during the ribosomal elongation cycle. Recent crystal structures of G proteins, such as elongation factor G (EF-G) bound to the ribosome, as well as many biochemical studies, provide evidence that the direct interaction of translational ...

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A {Omega}XaV motif in the Rift Valley fever virus NSs protein is essential for degrading p62, forming nuclear filaments and virulence [Biochemistry]

12-May-2015 | Normand Cyr; Cynthia de la Fuente; Lauriane Lecoq; Irene Guendel; Philippe R. Chabot; Kylene Kehn-Hall; James G. Omi ..., Proceedings of the National Academy of Sciences current issue, 2015

Rift Valley fever virus (RVFV) is a single-stranded RNA virus capable of inducing fatal hemorrhagic fever in humans. A key component of RVFV virulence is its ability to form nuclear filaments through interactions between the viral nonstructural protein NSs and the host general transcription ...

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Cas9-mediated targeting of viral RNA in eukaryotic cells [Microbiology]

12-May-2015 | Aryn A. Price; Timothy R. Sampson; Hannah K. Ratner; Arash Grakoui; David S. Weiss, Proceedings of the National Academy of Sciences current issue, 2015

Clustered, regularly interspaced, short palindromic repeats–CRISPR associated (CRISPR-Cas) systems are prokaryotic RNA-directed endonuclease machineries that act as an adaptive immune system against foreign genetic elements. Using small CRISPR RNAs that provide specificity, Cas proteins recognize ...

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Inactivation of EWS reduces PGC-1{alpha} protein stability and mitochondrial homeostasis [Cell Biology]

12-May-2015 | Jun Hong Park; Hong-Jun Kang; Yun Kyung Lee; Hyeog Kang; Jihyun Kim; Jay H. Chung; Ji Suk Chang; Alexandra C. McPher ..., Proceedings of the National Academy of Sciences current issue, 2015

EWS (Ewing sarcoma) encodes an RNA/ssDNA binding protein that is frequently rearranged in a number of different cancers by chromosomal translocations. Physiologically, EWS has diverse and essential roles in various organ development and cellular processes. In this study, we uncovered a new role ...

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Role for RNA:DNA hybrids in origin-independent replication priming in a eukaryotic system [Genetics]

05-May-2015 | Ruth Stuckey; Néstor García-Rodríguez; Andrés Aguilera; Ralf Erik Wellinger, Proceedings of the National Academy of Sciences current issue, 2015

DNA replication initiates at defined replication origins along eukaryotic chromosomes, ensuring complete genome duplication within a single S-phase. A key feature of replication origins is their ability to control the onset of DNA synthesis mediated by DNA polymerase-α and its intrinsic RNA ...

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