To use all functions of this page, please activate cookies in your browser.
My watch list
my.chemeurope.com
my.chemeurope.com
With an accout for my.chemeurope.com you can always see everything at a glance – and you can configure your own website and individual newsletter.
- My watch list
- My saved searches
- My saved topics
- My newsletter
422 Newest Publications in proceedings of the national academy of sciences current issue
rss
matching the following criteria
Escalation of polymerization in a thermal gradient [Evolution]
14-05-2013 | Christof B. Mast; Severin Schink; Ulrich Gerland; Dieter Braun, Proceedings of the National Academy of Sciences current issue, 2013
For the emergence of early life, the formation of biopolymers such as RNA is essential. However, the addition of nucleotide monomers to existing oligonucleotides requires millimolar concentrations. Even in such optimistic settings, no polymerization of RNA longer than about 20 bases could be ...
DTF1 is a core component of RNA-directed DNA methylation and may assist in the recruitment of Pol IV [Plant Biology]
14-05-2013 | Heng Zhang; Ze-Yang Ma; Liang Zeng; Kaori Tanaka; Cui-Jun Zhang; Jun Ma; Ge Bai; Pengcheng Wang; Su-Wei Zhang; Zhang ..., Proceedings of the National Academy of Sciences current issue, 2013
DNA methylation is an important epigenetic mark in many eukaryotic organisms. De novo DNA methylation in plants can be achieved by the RNA-directed DNA methylation (RdDM) pathway, where the plant-specific DNA-dependent RNA polymerase IV (Pol IV) transcribes target sequences to initiate 24-nt ...
Toxic RNA as a driver of disease in a common form of ALS and dementia [Genetics]
07-05-2013 | Harry T. Orr, Proceedings of the National Academy of Sciences current issue, 2013
A recent and very stimulating finding in the field of neurodegenerative disease is the discovery that expansion of a hexanucleotide microsatellite DNA repeat (GGGGCC) in an intron of the C90RF72 gene is a common cause of two devastating neurodegenerative diseases for which there are no cures: ...
Histone chaperone FACT action during transcription through chromatin by RNA polymerase II [Biochemistry]
07-05-2013 | Fu-Kai Hsieh; Olga I. Kulaeva; Smita S. Patel; Pamela N. Dyer; Karolin Luger; Danny Reinberg; Vasily M. Studitsky, Proceedings of the National Academy of Sciences current issue, 2013
FACT (facilitates chromatin transcription) is a histone chaperone that promotes chromatin recovery during transcription, with additional roles in cell differentiation. Although several models of the action of FACT during transcription have been proposed, they remain to be experimentally ...
Expanded GGGGCC repeat RNA associated with amyotrophic lateral sclerosis and frontotemporal dementia causes neurodegeneration [Genetics]
07-05-2013 | Zihui Xu; Mickael Poidevin; Xuekun Li; Yujing Li; Liqi Shu; David L. Nelson; He Li; Chadwick M. Hales; Marla Gearing ..., Proceedings of the National Academy of Sciences current issue, 2013
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) share phenotypic and pathologic overlap. Recently, an expansion of GGGGCC repeats in the first intron of C9orf72 was found to be a common cause of both illnesses; however, the molecular pathogenesis of this expanded repeat ...
Structural basis for encapsidation of genomic RNA by La Crosse Orthobunyavirus nucleoprotein [Biochemistry]
30-04-2013 | Juan Reguera; Hélène Malet; Friedemann Weber; Stephen Cusack, Proceedings of the National Academy of Sciences current issue, 2013
The nucleoprotein (NP) of segmented negative-strand RNA viruses such as Orthomyxo-, Arena-, and Bunyaviruses coats the genomic viral RNA and together with the polymerase forms ribonucleoprotein particles (RNPs), which are both the template for replication and transcription and are packaged ...
A strategy to capture and characterize the synaptic transcriptome [Neuroscience]
30-04-2013 | Sathyanarayanan V. Puthanveettil; Igor Antonov; Sergey Kalachikov; Priyamvada Rajasethupathy; Yun-Beom Choi; Andrea ..., Proceedings of the National Academy of Sciences current issue, 2013
Here we describe a strategy designed to identify RNAs that are actively transported to synapses during learning. Our approach is based on the characterization of RNA transport complexes carried by molecular motor kinesin. Using this strategy in Aplysia, we have identified 5,657 unique ...
Deciphering the rules of ceRNA networks [Mathematics]
30-04-2013 | Marcella Cesana; George Q. Daley, Proceedings of the National Academy of Sciences current issue, 2013
The Flip Side of miRNA FunctionRecent theoretical and experimental studies have shed light on the complex network of interactions among the multiple classes of RNA within the cell. Although much of the focus over the past decade has been on the mechanisms by which microRNAs (miRNA) regulate ...
Integrated transcriptional and competitive endogenous RNA networks are cross-regulated in permissive molecular environments [Cell Biology]
30-04-2013 | Ugo Ala; Florian A. Karreth; Carla Bosia; Andrea Pagnani; Riccardo Taulli; Valentine Léopold; Yvonne Tay; Paolo Prov ..., Proceedings of the National Academy of Sciences current issue, 2013
Competitive endogenous (ce)RNAs cross-regulate each other through sequestration of shared microRNAs and form complex regulatory networks based on their microRNA signature. However, the molecular requirements for ceRNA cross-regulation and the extent of ceRNA networks remain unknown. Here, we ...
T box RNA decodes both the information content and geometry of tRNA to affect gene expression [Biochemistry]
30-04-2013 | Jason C. Grigg; Yujie Chen; Frank J. Grundy; Tina M. Henkin; Lois Pollack; Ailong Ke, Proceedings of the National Academy of Sciences current issue, 2013
The T box leader sequence is an RNA element that controls gene expression by binding directly to a specific tRNA and sensing its aminoacylation state. This interaction controls expression of amino acid-related genes in a negative feedback loop. The T box RNA structure is highly conserved, but ...
Netmeeting
