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487 Newest Publications in proceedings of the national academy of sciences current issue

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Role for LSM genes in the regulation of circadian rhythms [Genetics]

21-10-2014 | Soledad Perez-Santángelo; Estefanía Mancini; Lauren J. Francey; Ruben Gustavo Schlaen; Ariel Chernomoretz; John B. H ..., Proceedings of the National Academy of Sciences current issue, 2014

Growing evidence suggests that core spliceosomal components differentially affect RNA processing of specific genes; however, whether changes in the levels or activities of these factors control specific signaling pathways is largely unknown. Here we show that some SM-like (LSM) genes, which ...

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Structural studies on the authentic mumps virus nucleocapsid showing uncoiling by the phosphoprotein [Microbiology]

21-10-2014 | Robert Cox; Adrian Pickar; Shihong Qiu; Jun Tsao; Cynthia Rodenburg; Terje Dokland; Andrew Elson; Biao He; Ming Luo, Proceedings of the National Academy of Sciences current issue, 2014

Mumps virus (MuV) is a highly contagious pathogen, and despite extensive vaccination campaigns, outbreaks continue to occur worldwide. The virus has a negative-sense, single-stranded RNA genome that is encapsidated by the nucleocapsid protein (N) to form the nucleocapsid (NC). NC serves as the ...

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Novel coding, translation, and gene expression of a replicating covalently closed circular RNA of 220 nt [Microbiology]

07-10-2014 | Mounir Georges AbouHaidar; Srividhya Venkataraman; Ashkan Golshani; Bolin Liu; Tauqeer Ahmad, Proceedings of the National Academy of Sciences current issue, 2014

The highly structured (64% GC) covalently closed circular (CCC) RNA (220 nt) of the virusoid associated with rice yellow mottle virus codes for a 16-kDa highly basic protein using novel modalities for coding, translation, and gene expression. This CCC RNA is the smallest among all known viroids ...

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Dominance of misfolded intermediates in the dynamics of {alpha}-helix folding [Physics]

07-10-2014 | Milo M. Lin; Dmitry Shorokhov; Ahmed H. Zewail, Proceedings of the National Academy of Sciences current issue, 2014

Helices are the “hydrogen atoms” of biomolecular complexity; the DNA/RNA double hairpin and protein α-helix ubiquitously form the building blocks of life’s constituents at the nanometer scale. Nevertheless, the formation processes of these structures, especially the dynamical pathways and rates, ...

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One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities [Microbiology]

16-09-2014 | Lorenzo Subissi; Clara C. Posthuma; Axelle Collet; Jessika C. Zevenhoven-Dobbe; Alexander E. Gorbalenya; Etienne Dec ..., Proceedings of the National Academy of Sciences current issue, 2014

In addition to members causing milder human infections, the Coronaviridae family includes potentially lethal zoonotic agents causing severe acute respiratory syndrome (SARS) and the recently emerged Middle East respiratory syndrome. The ∼30-kb positive-stranded RNA genome of coronaviruses encodes ...

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Mitochondrial reactive oxygen species are scavenged by Cockayne syndrome B protein in human fibroblasts without nuclear DNA damage [Medical Sciences]

16-09-2014 | James E. Cleaver; Angela M. Brennan-Minnella; Raymond A. Swanson; Ka-wing Fong; Junjie Chen; Kai-ming Chou; Yih-wen ..., Proceedings of the National Academy of Sciences current issue, 2014

Cockayne syndrome (CS) is a human DNA repair-deficient disease that involves transcription coupled repair (TCR), in which three gene products, Cockayne syndrome A (CSA), Cockayne syndrome B (CSB), and ultraviolet stimulated scaffold protein A (UVSSA) cooperate in relieving RNA polymerase II ...

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Temporally defined neocortical translation and polysome assembly are determined by the RNA-binding protein Hu antigen R [Neuroscience]

09-09-2014 | Matthew L. Kraushar; Kevin Thompson; H. R. Sagara Wijeratne; Barbara Viljetic; Kristina Sakers; Justin W. Marson; Di ..., Proceedings of the National Academy of Sciences current issue, 2014

Precise spatiotemporal control of mRNA translation machinery is essential to the development of highly complex systems like the neocortex. However, spatiotemporal regulation of translation machinery in the developing neocortex remains poorly understood. Here, we show that an RNA-binding protein, ...

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Structural basis for the fast self-cleavage reaction catalyzed by the twister ribozyme [Biochemistry]

09-09-2014 | Daniel Eiler; Jimin Wang; Thomas A. Steitz, Proceedings of the National Academy of Sciences current issue, 2014

Twister is a recently discovered RNA motif that is estimated to have one of the fastest known catalytic rates of any naturally occurring small self-cleaving ribozyme. We determined the 4.1-Å resolution crystal structure of a twister sequence from an organism that has not been cultured in ...

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RNA-guided endonuclease provides a therapeutic strategy to cure latent herpesviridae infection [Medical Sciences]

09-09-2014 | Jianbin Wang; Stephen R. Quake, Proceedings of the National Academy of Sciences current issue, 2014

Latent viral infection is a persistent cause of human disease. Although standard antiviral therapies can suppress active viral replication, no existing treatment can effectively eradicate latent infection and therefore a cure is lacking for many prevalent viral diseases. The prokaryotic immune ...

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Genetic and pharmacological reactivation of the mammalian inactive X chromosome [Cell Biology]

02-09-2014 | Sanchita Bhatnagar; Xiaochun Zhu; Jianhong Ou; Ling Lin; Lynn Chamberlain; Lihua J. Zhu; Narendra Wajapeyee; Michael ..., Proceedings of the National Academy of Sciences current issue, 2014

X-chromosome inactivation (XCI), the random transcriptional silencing of one X chromosome in somatic cells of female mammals, is a mechanism that ensures equal expression of X-linked genes in both sexes. XCI is initiated in cis by the noncoding Xist RNA, which coats the inactive X chromosome (Xi) ...

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