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531 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

Revealing the density of encoded functions in a viral RNA [Microbiology]

17-Feb-2015 | Nikesh Patel; Eric C. Dykeman; Robert H. A. Coutts; George P. Lomonossoff; David J. Rowlands; Simon E. V. Phillips; ..., Proceedings of the National Academy of Sciences current issue, 2015

We present direct experimental evidence that assembly of a single-stranded RNA virus occurs via a packaging signal-mediated mechanism. We show that the sequences of coat protein recognition motifs within multiple, dispersed, putative RNA packaging signals, as well as their relative spacing within ...

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Structural basis for transcription reactivation by RapA [Biochemistry]

17-Feb-2015 | Bin Liu; Yuhong Zuo; Thomas A. Steitz, Proceedings of the National Academy of Sciences current issue, 2015

RNA polymerase (RNAP) loses activity during transcription as it stalls at various inactive states due to erratic translocation. Reactivation of these stalled RNAPs is essential for efficient RNA synthesis. Here we report a 4.7-Å resolution crystal structure of the Escherichia coli RNAP core ...

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Double-stranded RNA made in C. elegans neurons can enter the germline and cause transgenerational gene silencing [Genetics]

17-Feb-2015 | Sindhuja Devanapally; Snusha Ravikumar; Antony M. Jose, Proceedings of the National Academy of Sciences current issue, 2015

An animal that can transfer gene-regulatory information from somatic cells to germ cells may be able to communicate changes in the soma from one generation to the next. In the worm Caenorhabditis elegans, expression of double-stranded RNA (dsRNA) in neurons can result in the export of ...

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Distinct pathways of RNA polymerase regulation by a phage-encoded factor [Biochemistry]

17-Feb-2015 | Daria Esyunina; Evgeny Klimuk; Konstantin Severinov; Andrey Kulbachinskiy, Proceedings of the National Academy of Sciences current issue, 2015

Transcription antitermination is a common strategy of gene expression regulation, but only a few transcription antitermination factors have been studied in detail. Here, we dissect the transcription antitermination mechanism of Xanthomonas oryzae virus Xp10 protein p7, which binds host RNA ...

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Differential RNA-seq of Vibrio cholerae identifies the VqmR small RNA as a regulator of biofilm formation [Microbiology]

17-Feb-2015 | Kai Papenfort; Konrad U. Förstner; Jian-Ping Cong; Cynthia M. Sharma; Bonnie L. Bassler, Proceedings of the National Academy of Sciences current issue, 2015

Quorum sensing (QS) is a process of cell-to-cell communication that enables bacteria to transition between individual and collective lifestyles. QS controls virulence and biofilm formation in Vibrio cholerae, the causative agent of cholera disease. Differential RNA sequencing (RNA-seq) of ...

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Absence of knots in known RNA structures [Biophysics and Computational Biology]

17-Feb-2015 | Cristian Micheletti; Marco Di Stefano; Henri Orland, Proceedings of the National Academy of Sciences current issue, 2015

The ongoing effort to detect and characterize physical entanglement in biopolymers has so far established that knots are present in many globular proteins and also, abound in viral DNA packaged inside bacteriophages. RNA molecules, however, have not yet been systematically screened for the ...

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Profile of Alberto Kornblihtt [Profiles]

17-Feb-2015 | Jennifer Viegas, Proceedings of the National Academy of Sciences current issue, 2015

Molecular biologist Alberto Kornblihtt is proud to work within a tightly knit group of Buenos Aires-based researchers who are studying ribonucleic acids. Kornblihtt and his team investigate the regulation of alternative RNA splicing, a process that affects nearly 90% of human genes. Kornblihtt, ...

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Bordetella pertussis fim3 gene regulation by BvgA: Phosphorylation controls the formation of inactive vs. active transcription complexes [Biochemistry]

10-Feb-2015 | Alice Boulanger; Kyung Moon; Kimberly B. Decker; Qing Chen; Leslie Knipling; Scott Stibitz; Deborah M. Hinton, Proceedings of the National Academy of Sciences current issue, 2015

Two-component systems [sensor kinase/response regulator (RR)] are major tools used by microorganisms to adapt to environmental conditions. RR phosphorylation is typically required for gene activation, but few studies have addressed how and if phosphorylation affects specific steps during ...

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Mechanism of RNA polymerase II bypass of oxidative cyclopurine DNA lesions [Biochemistry]

03-Feb-2015 | Celine Walmacq; Lanfeng Wang; Jenny Chong; Kathleen Scibelli; Lucyna Lubkowska; Averell Gnatt; Philip J. Brooks; Don ..., Proceedings of the National Academy of Sciences current issue, 2015

In human cells, the oxidative DNA lesion 8,5′-cyclo-2'-deoxyadenosine (CydA) induces prolonged stalling of RNA polymerase II (Pol II) followed by transcriptional bypass, generating both error-free and mutant transcripts with AMP misincorporated immediately downstream from the lesion. Here, we ...

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Translation initiation mediated by RNA looping [Biochemistry]

27-Jan-2015 | Ki Young Paek; Ka Young Hong; Incheol Ryu; Sung Mi Park; Sun Ju Keum; Oh Sung Kwon; Sung Key Jang, Proceedings of the National Academy of Sciences current issue, 2015

Eukaryotic translation initiation commences at the initiation codon near the 5′ end of mRNA by a 40S ribosomal subunit, and the recruitment of a 40S ribosome to an mRNA is facilitated by translation initiation factors interacting with the m7G cap and/or poly(A) tail. The 40S ribosome recruited to ...

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