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653 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

Discovery of RNA splicing and genes in pieces [Biochemistry]

26-Jan-2016 | Arnold J. Berk, Proceedings of the National Academy of Sciences current issue, 2016

The Problem: Short-Lived Heterogeneous Nuclear RNA During the 1960s and 1970s, there was a major conundrum in eukaryotic molecular biology regarding the synthesis of mRNA in animal cells. Pulse and pulse-chase radio-labeling experiments with tritiated uridine had shown that a large fraction of ...

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Molecular mechanism of viomycin inhibition of peptide elongation in bacteria [Biochemistry]

26-Jan-2016 | Mikael Holm; Anneli Borg; Måns Ehrenberg; Suparna Sanyal, Proceedings of the National Academy of Sciences current issue, 2016

Viomycin is a tuberactinomycin antibiotic essential for treating multidrug-resistant tuberculosis. It inhibits bacterial protein synthesis by blocking elongation factor G (EF-G) catalyzed translocation of messenger RNA on the ribosome. Here we have clarified the molecular aspects of viomycin ...

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Correction to Supporting Information for Lee et al., RNA design rules from a massive open laboratory [SI Corrections]

26-Jan-2016 | Proceedings of the National Academy of Sciences current issue, 2016

BIOCHEMISTRY Correction to Supporting Information for “RNA design rules from a massive open laboratory,” by Jeehyung Lee, Wipapat Kladwang, Minjae Lee, Daniel Cantu, Martin Azizyan, Hanjoo Kim, Alex Limpaecher, Snehal Gaikwad, Sungroh Yoon, Adrien Treuille, Rhiju Das, and EteRNA Participants, ...

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Bacterial RNA polymerase can retain {sigma}70 throughout transcription [Biochemistry]

19-Jan-2016 | Timothy T. Harden; Christopher D. Wells; Larry J. Friedman; Robert Landick; Ann Hochschild; Jane Kondev; Jeff Gelles, Proceedings of the National Academy of Sciences current issue, 2016

Production of a messenger RNA proceeds through sequential stages of transcription initiation and transcript elongation and termination. During each of these stages, RNA polymerase (RNAP) function is regulated by RNAP-associated protein factors. In bacteria, RNAP-associated σ factors are strictly ...

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Sustainable proliferation of liposomes compatible with inner RNA replication [Applied Biological Sciences]

19-Jan-2016 | Gakushi Tsuji; Satoshi Fujii; Takeshi Sunami; Tetsuya Yomo, Proceedings of the National Academy of Sciences current issue, 2016

Although challenging, the construction of a life-like compartment via a bottom–up approach can increase our understanding of life and protocells. The sustainable replication of genome information and the proliferation of phospholipid vesicles are requisites for reconstituting cell growth. ...

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Sex-specific silencing of X-linked genes by Xist RNA [Genetics]

19-Jan-2016 | Srimonta Gayen; Emily Maclary; Michael Hinten; Sundeep Kalantry, Proceedings of the National Academy of Sciences current issue, 2016

X-inactive specific transcript (Xist) long noncoding RNA (lncRNA) is thought to catalyze silencing of X-linked genes in cis during X-chromosome inactivation, which equalizes X-linked gene dosage between male and female mammals. To test the impact of Xist RNA on X-linked gene silencing, we ...

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HIV-1 RNA genome dimerizes on the plasma membrane in the presence of Gag protein [Microbiology]

12-Jan-2016 | Jianbo Chen; Sheikh Abdul Rahman; Olga A. Nikolaitchik; David Grunwald; Luca Sardo; Ryan C. Burdick; Sergey Plisov; ..., Proceedings of the National Academy of Sciences current issue, 2016

Retroviruses package a dimeric genome comprising two copies of the viral RNA. Each RNA contains all of the genetic information for viral replication. Packaging a dimeric genome allows the recovery of genetic information from damaged RNA genomes during DNA synthesis and promotes frequent ...

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Understanding the kinetic mechanism of RNA single base pair formation [Biophysics and Computational Biology]

05-Jan-2016 | Xiaojun Xu; Tao Yu; Shi-Jie Chen, Proceedings of the National Academy of Sciences current issue, 2016

RNA functions are intrinsically tied to folding kinetics. The most elementary step in RNA folding is the closing and opening of a base pair. Understanding this elementary rate process is the basis for RNA folding kinetics studies. Previous studies mostly focused on the unfolding of base pairs. ...

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Correction to Supporting Information for Parshin et al., DksA regulates RNA polymerase in Escherichia coli through a network of interactions in the secondary channel that includes Sequence Insertion 1 [SI Corrections]

05-Jan-2016 | Proceedings of the National Academy of Sciences current issue, 2016

BIOCHEMISTRY Correction to Supporting Information for “DksA regulates RNA polymerase in Escherichia coli through a network of interactions in the secondary channel that includes Sequence Insertion 1,” by Andrey Parshin, Anthony L. Shiver, Jookyung Lee, Maria Ozerova, Dina Schneidman-Duhovny, ...

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Casein kinase II promotes target silencing by miRISC through direct phosphorylation of the DEAD-box RNA helicase CGH-1 [Genetics]

29-Dec-2015 | Amelia F. Alessi; Vishal Khivansara; Ting Han; Mallory A. Freeberg; James J. Moresco; Patricia G. Tu; Eric Montoye; ..., Proceedings of the National Academy of Sciences current issue, 2015

MicroRNAs (miRNAs) play essential, conserved roles in diverse developmental processes through association with the miRNA-induced silencing complex (miRISC). Whereas fundamental insights into the mechanistic framework of miRNA biogenesis and target gene silencing have been established, ...

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