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505 Newest Publications in proceedings of the national academy of sciences current issue

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Comparison of the transcriptional landscapes between human and mouse tissues [Genetics]

02-12-2014 | Shin Lin; Yiing Lin; Joseph R. Nery; Mark A. Urich; Alessandra Breschi; Carrie A. Davis; Alexander Dobin; Christophe ..., Proceedings of the National Academy of Sciences current issue, 2014

Although the similarities between humans and mice are typically highlighted, morphologically and genetically, there are many differences. To better understand these two species on a molecular level, we performed a comparison of the expression profiles of 15 tissues by deep RNA sequencing and ...

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Cytoplasmic HIV-1 RNA is mainly transported by diffusion in the presence or absence of Gag protein [Microbiology]

02-12-2014 | Jianbo Chen; David Grunwald; Luca Sardo; Andrea Galli; Sergey Plisov; Olga A. Nikolaitchik; De Chen; Stephen Lockett ..., Proceedings of the National Academy of Sciences current issue, 2014

Full-length HIV-1 RNA plays a central role in viral replication by serving as the mRNA for essential viral proteins and as the genome packaged into infectious virions. Proper RNA trafficking is required for the functions of RNA and its encoded proteins; however, the mechanism by which HIV-1 RNA ...

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In vitro evolution of high-titer, virus-like vesicles containing a single structural protein [Microbiology]

25-11-2014 | Nina F. Rose; Linda Buonocore; John B. Schell; Anasuya Chattopadhyay; Kapil Bahl; Xinran Liu; John K. Rose, Proceedings of the National Academy of Sciences current issue, 2014

Self-propagating, infectious, virus-like vesicles (VLVs) are generated when an alphavirus RNA replicon expresses the vesicular stomatitis virus glycoprotein (VSV G) as the only structural protein. The mechanism that generates these VLVs lacking a capsid protein has remained a mystery for over 20 ...

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H19 long noncoding RNA controls the mRNA decay promoting function of KSRP [Cell Biology]

25-11-2014 | Matteo Giovarelli; Gabriele Bucci; Andres Ramos; Domenico Bordo; Carol J. Wilusz; Ching-Yi Chen; Margherita Puppo; P ..., Proceedings of the National Academy of Sciences current issue, 2014

Long noncoding RNAs (lncRNAs) interact with protein factors to regulate different layers of gene expression transcriptionally or posttranscriptionally. Here we report on the functional consequences of the unanticipated interaction of the RNA binding protein K homology-type splicing regulatory ...

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Sample processing obscures cancer-specific alterations in leukemic transcriptomes [Genetics]

25-11-2014 | Heidi Dvinge; Rhonda E. Ries; Janine O. Ilagan; Derek L. Stirewalt; Soheil Meshinchi; Robert K. Bradley, Proceedings of the National Academy of Sciences current issue, 2014

Substantial effort is currently devoted to identifying cancer-associated alterations using genomics. Here, we show that standard blood collection procedures rapidly change the transcriptional and posttranscriptional landscapes of hematopoietic cells, resulting in biased activation of specific ...

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Influenza A virus nucleoprotein selectively decreases neuraminidase gene-segment packaging while enhancing viral fitness and transmissibility [Microbiology]

25-11-2014 | Christopher B. Brooke; William L. Ince; Jiajie Wei; Jack R. Bennink; Jonathan W. Yewdell, Proceedings of the National Academy of Sciences current issue, 2014

The influenza A virus (IAV) genome is divided into eight distinct RNA segments believed to be copackaged into virions with nearly perfect efficiency. Here, we describe a mutation in IAV nucleoprotein (NP) that enhances replication and transmission in guinea pigs while selectively reducing ...

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Molecular insights into DNA interference by CRISPR-associated nuclease-helicase Cas3 [Biochemistry]

18-11-2014 | Bei Gong; Minsang Shin; Jiali Sun; Che-Hun Jung; Edward L. Bolt; John van der Oost; Jeong-Sun Kim, Proceedings of the National Academy of Sciences current issue, 2014

Mobile genetic elements in bacteria are neutralized by a system based on clustered regularly interspaced short palindromic repeats (CRISPRs) and CRISPR-associated (Cas) proteins. Type I CRISPR-Cas systems use a “Cascade” ribonucleoprotein complex to guide RNA specifically to complementary ...

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The AAA-ATPase molecular chaperone Cdc48/p97 disassembles sumoylated centromeres, decondenses heterochromatin, and activates ribosomal RNA genes [Plant Biology]

11-11-2014 | Zsuzsanna Mérai; Nina Chumak; Marcelina García-Aguilar; Tzung-Fu Hsieh; Toshiro Nishimura; Vera K. Schoft; János Bin ..., Proceedings of the National Academy of Sciences current issue, 2014

Centromeres mediate chromosome segregation and are defined by the centromere-specific histone H3 variant (CenH3)/centromere protein A (CENP-A). Removal of CenH3 from centromeres is a general property of terminally differentiated cells, and the persistence of CenH3 increases the risk of diseases ...

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Arabidopsis protein arginine methyltransferase 3 is required for ribosome biogenesis by affecting precursor ribosomal RNA processing [Plant Biology]

11-11-2014 | Runlai Hang; Chunyan Liu; Ayaz Ahmad; Yong Zhang; Falong Lu; Xiaofeng Cao, Proceedings of the National Academy of Sciences current issue, 2014

Ribosome biogenesis is a fundamental and tightly regulated cellular process, including synthesis, processing, and assembly of rRNAs with ribosomal proteins. Protein arginine methyltransferases (PRMTs) have been implicated in many important biological processes, such as ribosome biogenesis. Two ...

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Functional conservation despite structural divergence in ligand-responsive RNA switches [Biochemistry]

11-11-2014 | Mark A. Boerneke; Sergey M. Dibrov; Jing Gu; David L. Wyles; Thomas Hermann, Proceedings of the National Academy of Sciences current issue, 2014

An internal ribosome entry site (IRES) initiates protein synthesis in RNA viruses, including the hepatitis C virus (HCV). We have discovered ligand-responsive conformational switches in viral IRES elements. Modular RNA motifs of greatly distinct sequence and local secondary structure have been ...

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