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546 Newest Publications in proceedings of the national academy of sciences current issue

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Robust and sustained immune activation in human Ebola virus infection [Immunology and Inflammation]

14-Apr-2015 | Judith N. Mandl; Mark B. Feinberg, Proceedings of the National Academy of Sciences current issue, 2015

Ebola viruses (EBOV) are zoonotic infectious agents that are highly pathogenic in humans, causing severe hemorrhagic fever with fatality rates of ∼50–70% (1). This genus of negative single-stranded RNA viruses consists of five known species that are part of the Filoviridae family. The current ...

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SWI/SNF chromatin-remodeling complexes function in noncoding RNA-dependent assembly of nuclear bodies [Biochemistry]

07-Apr-2015 | Tetsuya Kawaguchi; Akie Tanigawa; Takao Naganuma; Yasuyuki Ohkawa; Sylvie Souquere; Gerard Pierron; Tetsuro Hirose, Proceedings of the National Academy of Sciences current issue, 2015

Paraspeckles are subnuclear structures that form around nuclear paraspeckle assembly transcript 1 (NEAT1) long noncoding RNA (lncRNA). Recently, paraspeckles were shown to be functional nuclear bodies involved in stress responses and the development of specific organs. Paraspeckle formation is ...

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Structure of the paramyxovirus parainfluenza virus 5 nucleoprotein-RNA complex [Microbiology]

07-Apr-2015 | Maher Alayyoubi; George P. Leser; Christopher A. Kors; Robert A. Lamb, Proceedings of the National Academy of Sciences current issue, 2015

Parainfluenza virus 5 (PIV5) is a member of the Paramyxoviridae family of membrane-enveloped viruses with a negative-sense RNA genome that is packaged and protected by long filamentous nucleocapsid-helix structures (RNPs). These RNPs, consisting of ∼2,600 protomers of nucleocapsid (N) protein, ...

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Immunoglobulin transcript sequence and somatic hypermutation computation from unselected RNA-seq reads in chronic lymphocytic leukemia [Biophysics and Computational Biology]

07-Apr-2015 | James S. Blachly; Amy S. Ruppert; Weiqiang Zhao; Susan Long; Joseph Flynn; Ian Flinn; Jeffrey Jones; Kami Maddocks; ..., Proceedings of the National Academy of Sciences current issue, 2015

Immunoglobulins (Ig) are produced by B lymphocytes as secreted antibodies or as part of the B-cell receptor. There is tremendous diversity of potential Ig transcripts (>1 × 1012) as a result of hundreds of germ-line gene segments, random nucleotide incorporation during joining of gene segments ...

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Glucocorticoid receptor interacts with PNRC2 in a ligand-dependent manner to recruit UPF1 for rapid mRNA degradation [Biochemistry]

31-Mar-2015 | Hana Cho; Ok Hyun Park; Joori Park; Incheol Ryu; Jeonghan Kim; Jesang Ko; Yoon Ki Kim, Proceedings of the National Academy of Sciences current issue, 2015

Glucocorticoid receptor (GR), which was originally known to function as a nuclear receptor, plays a role in rapid mRNA degradation by acting as an RNA-binding protein. The mechanism by which this process occurs remains unknown. Here, we demonstrate that GR, preloaded onto the 5′UTR of a target ...

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Structural mechanism of sensing long dsRNA via a noncatalytic domain in human oligoadenylate synthetase 3 [Biochemistry]

31-Mar-2015 | Jesse Donovan; Gena Whitney; Sneha Rath; Alexei Korennykh, Proceedings of the National Academy of Sciences current issue, 2015

The mammalian innate immune system uses several sensors of double-stranded RNA (dsRNA) to develop the interferon response. Among these sensors are dsRNA-activated oligoadenylate synthetases (OAS), which produce signaling 2′,5′-linked RNA molecules (2-5A) that activate regulated RNA decay in ...

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Functionally conserved architecture of hepatitis C virus RNA genomes [Biochemistry]

24-Mar-2015 | David M. Mauger; Michael Golden; Daisuke Yamane; Sara Williford; Stanley M. Lemon; Darren P. Martin; Kevin M. Weeks, Proceedings of the National Academy of Sciences current issue, 2015

Hepatitis C virus (HCV) infects over 170 million people worldwide and is a leading cause of liver disease and cancer. The virus has a 9,650-nt, single-stranded, messenger-sense RNA genome that is infectious as an independent entity. The RNA genome has evolved in response to complex selection ...

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Boosting CRISPR/Cas9 multiplex editing capability with the endogenous tRNA-processing system [Plant Biology]

17-Mar-2015 | Kabin Xie; Bastian Minkenberg; Yinong Yang, Proceedings of the National Academy of Sciences current issue, 2015

The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9 nuclease (Cas9) system is being harnessed as a powerful tool for genome engineering in basic research, molecular therapy, and crop improvement. This system uses a small guide RNA (gRNA) to direct ...

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The RNA binding protein FXR1 is a new driver in the 3q26-29 amplicon and predicts poor prognosis in human cancers [Medical Sciences]

17-Mar-2015 | Jun Qian; Mohamed Hassanein; Megan D. Hoeksema; Bradford K. Harris; Yong Zou; Heidi Chen; Pengcheng Lu; Rosana Eisen ..., Proceedings of the National Academy of Sciences current issue, 2015

Aberrant expression of RNA-binding proteins has profound implications for cellular physiology and the pathogenesis of human diseases such as cancer. We previously identified the Fragile X-Related 1 gene (FXR1) as one amplified candidate driver gene at 3q26-29 in lung squamous cell carcinoma ...

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Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs [Genetics]

10-Mar-2015 | Eric Londin; Phillipe Loher; Aristeidis G. Telonis; Kevin Quann; Peter Clark; Yi Jing; Eleftheria Hatzimichael; Yohe ..., Proceedings of the National Academy of Sciences current issue, 2015

Two decades after the discovery of the first animal microRNA (miRNA), the number of miRNAs in animal genomes remains a vexing question. Here, we report findings from analyzing 1,323 short RNA sequencing samples (RNA-seq) from 13 different human tissue types. Using stringent thresholding criteria, ...

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