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515 Newest Publications in proceedings of the national academy of sciences current issue

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Structural basis of HIV-1 capsid recognition by PF74 and CPSF6 [Biophysics and Computational Biology]

30-Dec-2014 | Akash Bhattacharya; Steven L. Alam; Thomas Fricke; Kaneil Zadrozny; Jaroslaw Sedzicki; Alexander B. Taylor; Borries ..., Proceedings of the National Academy of Sciences current issue, 2014

Upon infection of susceptible cells by HIV-1, the conical capsid formed by ∼250 hexamers and 12 pentamers of the CA protein is delivered to the cytoplasm. The capsid shields the RNA genome and proteins required for reverse transcription. In addition, the surface of the capsid mediates numerous ...

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Mice deficient in Rbm38, a target of the p53 family, are susceptible to accelerated aging and spontaneous tumors [Cell Biology]

30-Dec-2014 | Jin Zhang; Enshun Xu; Cong Ren; Wensheng Yan; Min Zhang; Mingyi Chen; Robert D. Cardiff; Denise M. Imai; Erik Wisner ..., Proceedings of the National Academy of Sciences current issue, 2014

RNA-binding motif protein 38 (Rbm38), also called RNPC1 [RNA-binding region (RNP1, RRM) containing 1], is a target of the p53 family and modulates p53 expression via mRNA translation. To investigate the biological function of Rbm38 in vivo, we generated an Rbm38-null mouse model. We showed that ...

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A divergent Pumilio repeat protein family for pre-rRNA processing and mRNA localization [Biochemistry]

30-Dec-2014 | Chen Qiu; Kathleen L. McCann; Robert N. Wine; Susan J. Baserga; Traci M. Tanaka Hall, Proceedings of the National Academy of Sciences current issue, 2014

Pumilio/feminization of XX and XO animals (fem)-3 mRNA-binding factor (PUF) proteins bind sequence specifically to mRNA targets using a single-stranded RNA-binding domain comprising eight Pumilio (PUM) repeats. PUM repeats have now been identified in proteins that function in pre-rRNA processing, ...

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A long noncoding RNA connects c-Myc to tumor metabolism [Medical Sciences]

30-Dec-2014 | Chiu-Lien Hung; Ling-Yu Wang; Yen-Ling Yu; Hong-Wu Chen; Shiv Srivastava; Gyorgy Petrovics; Hsing-Jien Kung, Proceedings of the National Academy of Sciences current issue, 2014

Long noncoding RNAs (lncRNAs) have been implicated in a variety of physiological and pathological processes, including cancer. In prostate cancer, prostate cancer gene expression marker 1 (PCGEM1) is an androgen-induced prostate-specific lncRNA whose overexpression is highly associated with ...

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Treacher Collins syndrome TCOF1 protein cooperates with NBS1 in the DNA damage response [Cell Biology]

30-Dec-2014 | Alberto Ciccia; Jen-Wei Huang; Lior Izhar; Mathew E. Sowa; J. Wade Harper; Stephen J. Elledge, Proceedings of the National Academy of Sciences current issue, 2014

The signal transduction pathway of the DNA damage response (DDR) is activated to maintain genomic integrity following DNA damage. The DDR promotes genomic integrity by regulating a large network of cellular activities that range from DNA replication and repair to transcription, RNA splicing, and ...

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Structural and functional studies of Bud23-Trm112 reveal 18S rRNA N7-G1575 methylation occurs on late 40S precursor ribosomes [Biochemistry]

23-Dec-2014 | Juliette Létoquart; Emmeline Huvelle; Ludivine Wacheul; Gabrielle Bourgeois; Christiane Zorbas; Marc Graille; Valéri ..., Proceedings of the National Academy of Sciences current issue, 2014

The eukaryotic small ribosomal subunit carries only four ribosomal (r) RNA methylated bases, all close to important functional sites. N7-methylguanosine (m7G) introduced at position 1575 on 18S rRNA by Bud23–Trm112 is at a ridge forming a steric block between P- and E-site tRNAs. Here we report ...

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rMATS: Robust and flexible detection of differential alternative splicing from replicate RNA-Seq data [Systems Biology]

23-Dec-2014 | Shihao Shen; Juw Won Park; Zhi-xiang Lu; Lan Lin; Michael D. Henry; Ying Nian Wu; Qing Zhou; Yi Xing, Proceedings of the National Academy of Sciences current issue, 2014

Ultra-deep RNA sequencing (RNA-Seq) has become a powerful approach for genome-wide analysis of pre-mRNA alternative splicing. We previously developed multivariate analysis of transcript splicing (MATS), a statistical method for detecting differential alternative splicing between two RNA-Seq ...

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ELAVL1 regulates alternative splicing of eIF4E transporter to promote postnatal angiogenesis [Medical Sciences]

23-Dec-2014 | Sung-Hee Chang; Olivier Elemento; Jiasheng Zhang; Zhen W. Zhuang; Michael Simons; Timothy Hla, Proceedings of the National Academy of Sciences current issue, 2014

Posttranscriptional RNA regulation is important in determining the plasticity of cellular phenotypes. However, mechanisms of how RNA binding proteins (RBPs) influence cellular behavior are poorly understood. We show here that the RBP embryonic lethal abnormal vision like 1 (ELAVL1, also know as ...

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Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma [Medical Sciences]

23-Dec-2014 | Jennifer A. Perry; Adam Kiezun; Peter Tonzi; Eliezer M. Van Allen; Scott L. Carter; Sylvan C. Baca; Glenn S. Cowley; ..., Proceedings of the National Academy of Sciences current issue, 2014

Osteosarcoma is the most common primary bone tumor, yet there have been no substantial advances in treatment or survival in three decades. We examined 59 tumor/normal pairs by whole-exome, whole-genome, and RNA-sequencing. Only the TP53 gene was mutated at significant frequency across all ...

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Self-assembled FUS binds active chromatin and regulates gene transcription [Biochemistry]

16-Dec-2014 | Liuqing Yang; Jozsef Gal; Jing Chen; Haining Zhu, Proceedings of the National Academy of Sciences current issue, 2014

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease. Fused in sarcoma (FUS) is a DNA/RNA binding protein and mutations in FUS cause a subset of familial ALS. Most ALS mutations are clustered in the C-terminal nuclear localization sequence of FUS and consequently lead to ...

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