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291 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

GABAB autoreceptor-mediated cell type-specific reduction of inhibition in epileptic mice [Neuroscience]

10-09-2013 | Tamar Dugladze; Nino Maziashvili; Christoph Börgers; Shalva Gurgenidze; Ute Häussler; Aline Winkelmann; Carola A. Ha ..., Proceedings of the National Academy of Sciences current issue, 2013

GABAB receptors (GABABRs) mediate slow inhibitory effects on neuronal excitability and synaptic transmission in the brain. However, the GABABR agonist baclofen can also promote excitability and seizure generation in human patients and animals models. Here we show that baclofen has ...

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let-7 and miR-140 microRNAs coordinately regulate skeletal development [Developmental Biology]

27-08-2013 | Garyfallia Papaioannou; Jennifer B. Inloes; Yukio Nakamura; Elena Paltrinieri; Tatsuya Kobayashi, Proceedings of the National Academy of Sciences current issue, 2013

MicroRNAs (miRNAs) play critical roles in multiple processes of skeletal development. A global reduction of miRNAs in growth plate chondrocytes results in defects in both proliferation and differentiation; however, specific microRNAs responsible for these defects have not been identified. In this ...

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Comparison of geomechanical deformation induced by megatonne-scale CO2 storage at Sleipner, Weyburn, and In Salah [Earth, Atmospheric, and Planetary Sciences]

23-07-2013 | James P. Verdon; J.-Michael Kendall; Anna L. Stork; R. Andy Chadwick; Don J. White; Rob C. Bissell, Proceedings of the National Academy of Sciences current issue, 2013

Geological storage of CO2 that has been captured at large, point source emitters represents a key potential method for reduction of anthropogenic greenhouse gas emissions. However, this technology will only be viable if it can be guaranteed that injected CO2 will remain trapped in the subsurface ...

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Regional variations in the health, environmental, and climate benefits of wind and solar generation [Sustainability Science]

16-07-2013 | Kyle Siler-Evans; Inês Lima Azevedo; M. Granger Morgan; Jay Apt, Proceedings of the National Academy of Sciences current issue, 2013

When wind or solar energy displace conventional generation, the reduction in emissions varies dramatically across the United States. Although the Southwest has the greatest solar resource, a solar panel in New Jersey displaces significantly more sulfur dioxide, nitrogen oxides, and particulate ...

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Metabolic rates and sulfur cycling in the geologic record [Earth, Atmospheric, and Planetary Sciences]

09-07-2013 | Nanping Wu; James Farquhar, Proceedings of the National Academy of Sciences current issue, 2013

In PNAS, Leavitt et al. (1) describe the shared dependence of cell-specific sulfate reduction rate and sulfur isotope fractionations on the availability of a single electron donor for the model sulfate reducer, Desulfovibrio vulgaris Hildenborough. These authors then use their findings in a ...

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Influence of sulfate reduction rates on the Phanerozoic sulfur isotope record [Microbiology]

09-07-2013 | William D. Leavitt; Itay Halevy; Alexander S. Bradley; David T. Johnston, Proceedings of the National Academy of Sciences current issue, 2013

Phanerozoic levels of atmospheric oxygen relate to the burial histories of organic carbon and pyrite sulfur. The sulfur cycle remains poorly constrained, however, leading to concomitant uncertainties in O2 budgets. Here we present experiments linking the magnitude of fractionations of the ...

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Reduction potentials of heterometallic manganese-oxido cubane complexes modulated by redox-inactive metals [Chemistry]

18-06-2013 | Emily Y. Tsui; Theodor Agapie, Proceedings of the National Academy of Sciences current issue, 2013

Understanding the effect of redox-inactive metals on the properties of biological and heterogeneous water oxidation catalysts is important both fundamentally and for improvement of future catalyst designs. In this work, heterometallic manganese–oxido cubane clusters [MMn3O4] (M = Sr2+, Zn2+, ...

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Deliberate reduction of hemagglutinin and neuraminidase expression of influenza virus leads to an ultraprotective live vaccine in mice [Microbiology]

04-06-2013 | Chen Yang; Steven Skiena; Bruce Futcher; Steffen Mueller; Eckard Wimmer, Proceedings of the National Academy of Sciences current issue, 2013

A long-held dogma posits that strong presentation to the immune system of the dominant influenza virus glycoprotein antigens neuraminidase (NA) and hemagglutinin (HA) is paramount for inducing protective immunity against influenza virus infection. We have deliberately violated this dogma by ...

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LYM2-dependent chitin perception limits molecular flux via plasmodesmata [Plant Biology]

28-05-2013 | Christine Faulkner; Elena Petutschnig; Yoselin Benitez-Alfonso; Martina Beck; Silke Robatzek; Volker Lipka; Andrew J ..., Proceedings of the National Academy of Sciences current issue, 2013

Chitin acts as a pathogen-associated molecular pattern from fungal pathogens whose perception triggers a range of defense responses. We show that LYSIN MOTIF DOMAIN-CONTAINING GLYCOSYLPHOSPHATIDYLINOSITOL-ANCHORED PROTEIN 2 (LYM2), the Arabidopsis homolog of a rice chitin receptor-like protein, ...

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Sulfur isotopes in coal constrain the evolution of the Phanerozoic sulfur cycle [Earth, Atmospheric, and Planetary Sciences]

21-05-2013 | Donald E. Canfield, Proceedings of the National Academy of Sciences current issue, 2013

Sulfate is the second most abundant anion (behind chloride) in modern seawater, and its cycling is intimately coupled to the cycling of organic matter and oxygen at the Earth’s surface. For example, the reduction of sulfide by microbes oxidizes vast amounts of organic carbon and the subsequent ...

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