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322 Newest Publications in proceedings of the national academy of sciences current issue

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Reduction of toxic RNAs in myotonic dystrophies type 1 and type 2 by the RNA helicase p68/DDX5 [Genetics]

30-Jun-2015 | Karlie Jones; Christina Wei; Benedikt Schoser; Giovanni Meola; Nikolai Timchenko; Lubov Timchenko, Proceedings of the National Academy of Sciences current issue, 2015

Myotonic dystrophies type 1 (DM1) and type 2 (DM2) are neuromuscular diseases, caused by accumulation of CUG and CCUG RNAs in toxic aggregates. Here we report that the increased stability of the mutant RNAs in both types of DM is caused by deficiency of RNA helicase p68. We have identified...

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Parental care buffers against inbreeding depression in burying beetles [Evolution]

30-Jun-2015 | Natalie Pilakouta; Seonaidh Jamieson; Jacob A. Moorad; Per T. Smiseth, Proceedings of the National Academy of Sciences current issue, 2015

When relatives mate, their inbred offspring often suffer a reduction in fitness-related traits known as “inbreeding depression.” There is mounting evidence that inbreeding depression can be exacerbated by environmental stresses such as starvation, predation, parasitism, and competition. Parental ...

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A universal entropy-driven mechanism for thioredoxin-target recognition [Biochemistry]

30-Jun-2015 | Prakash B. Palde; Kate S. Carroll, Proceedings of the National Academy of Sciences current issue, 2015

Cysteine residues in cytosolic proteins are maintained in their reduced state, but can undergo oxidation owing to posttranslational modification during redox signaling or under conditions of oxidative stress. In large part, the reduction of oxidized protein cysteines is mediated by a small 12-kDa ...

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Navigating complexity through knowledge coproduction: Mainstreaming ecosystem services into disaster risk reduction [Biological Sciences]

16-Jun-2015 | Belinda Reyers; Jeanne L. Nel; Patrick J. O’Farrell; Nadia Sitas; Deon C. Nel, Proceedings of the National Academy of Sciences current issue, 2015

Achieving the policy and practice shifts needed to secure ecosystem services is hampered by the inherent complexities of ecosystem services and their management. Methods for the participatory production and exchange of knowledge offer an avenue to navigate this complexity together with the ...

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Specific heat and sound velocity at the relevant competing phase of high-temperature superconductors [Physics]

19-May-2015 | Chandra M. Varma; Lijun Zhu, Proceedings of the National Academy of Sciences current issue, 2015

Recent highly accurate sound velocity measurements reveal a phase transition to a competing phase in YBa2Cu3O6+δ that is not identified in available specific heat measurements. We show that this signature is consistent with the universality class of the loop current-ordered state when the ...

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Reply to van de Sandt and Rimmelzwaan: Matching epitope display with functional avidity [Biological Sciences]

12-May-2015 | Derin B. Keskin; Bruce R. Reinhold; Guang Lan Zhang; Alexander R. Ivanov; Barry L. Karger; Ellis L. Reinherz, Proceedings of the National Academy of Sciences current issue, 2015

We appreciate the comments of van de Sandt and Rimmelzwaan (1) on our paper (2), as well as the opportunity to respond. First, we agree that in Berkhoff et al. (3) single alanine replacements resulted in reduced kinetics of viral replication. Nonetheless, to claim “a reduction of progeny virus ...

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Major reorientation of tRNA substrates defines specificity of dihydrouridine synthases [Biochemistry]

12-May-2015 | Robert T. Byrne; Huw T. Jenkins; Daniel T. Peters; Fiona Whelan; James Stowell; Naveed Aziz; Pavel Kasatsky; Marina ..., Proceedings of the National Academy of Sciences current issue, 2015

The reduction of specific uridines to dihydrouridine is one of the most common modifications in tRNA. Increased levels of the dihydrouridine modification are associated with cancer. Dihydrouridine synthases (Dus) from different subfamilies selectively reduce distinct uridines, located at ...

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Structure-relaxation mechanism for the response of T4 lysozyme cavity mutants to hydrostatic pressure [Biophysics and Computational Biology]

12-May-2015 | Michael T. Lerch; Carlos J. López; Zhongyu Yang; Margaux J. Kreitman; Joseph Horwitz; Wayne L. Hubbell, Proceedings of the National Academy of Sciences current issue, 2015

Application of hydrostatic pressure shifts protein conformational equilibria in a direction to reduce the volume of the system. A current view is that the volume reduction is dominated by elimination of voids or cavities in the protein interior via cavity hydration, although an alternative ...

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Sterile inflammation in the spleen during atherosclerosis provides oxidation-specific epitopes that induce a protective B-cell response [Immunology and Inflammation]

21-Apr-2015 | Emilie K. Grasset; Amanda Duhlin; Hanna E. Agardh; Olga Ovchinnikova; Thomas Hägglöf; Mattias N. Forsell; Gabrielle ..., Proceedings of the National Academy of Sciences current issue, 2015

The B-cell response in atherosclerosis is directed toward oxidation-specific epitopes such as phosphorylcholine (PC) that arise during disease-driven oxidation of self-antigens. PC-bearing antigens have been used to induce atheroprotective antibodies against modified low-density lipoproteins ...

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Cortical activity is more stable when sensory stimuli are consciously perceived [Neuroscience]

21-Apr-2015 | Aaron Schurger; Ioannis Sarigiannidis; Lionel Naccache; Jacobo D. Sitt; Stanislas Dehaene, Proceedings of the National Academy of Sciences current issue, 2015

According to recent evidence, stimulus-tuned neurons in the cerebral cortex exhibit reduced variability in firing rate across trials, after the onset of a stimulus. However, in order for a reduction in variability to be directly relevant to perception and behavior, it must be realized within ...

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