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299 Newest Publications in proceedings of the national academy of sciences current issue

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Timing and heterogeneity of mutations associated with drug resistance in metastatic cancers [Applied Mathematics]

11-11-2014 | Ivana Bozic; Martin A. Nowak, Proceedings of the National Academy of Sciences current issue, 2014

Targeted therapies provide an exciting new approach to combat human cancer. The immediate effect is a dramatic reduction in disease burden, but in most cases, the tumor returns as a consequence of resistance. Various mechanisms for the evolution of resistance have been implicated, including ...

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Vegetation dynamics and rainfall sensitivity of the Amazon [Environmental Sciences]

11-11-2014 | Thomas Hilker; Alexei I. Lyapustin; Compton J. Tucker; Forrest G. Hall; Ranga B. Myneni; Yujie Wang; Jian Bi; Yhasmi ..., Proceedings of the National Academy of Sciences current issue, 2014

We show that the vegetation canopy of the Amazon rainforest is highly sensitive to changes in precipitation patterns and that reduction in rainfall since 2000 has diminished vegetation greenness across large parts of Amazonia. Large-scale directional declines in vegetation greenness may indicate ...

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Beclin-1 deficiency in the murine ovary results in the reduction of progesterone production to promote preterm labor [Developmental Biology]

07-10-2014 | Thomas R. Gawriluk; CheMyong Ko; Xiaoman Hong; Lane K. Christenson; Edmund B. Rucker III, Proceedings of the National Academy of Sciences current issue, 2014

Autophagy is an important cellular process that serves as a companion pathway to the ubiquitin-proteasome system to degrade long-lived proteins and organelles to maintain cell homeostasis. Although initially characterized in yeast, autophagy is being realized as an important regulator of ...

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Iron oxides stimulate sulfate-driven anaerobic methane oxidation in seeps [Earth, Atmospheric, and Planetary Sciences]

07-10-2014 | Orit Sivan; Gilad Antler; Alexandra V. Turchyn; Jeffrey J. Marlow; Victoria J. Orphan, Proceedings of the National Academy of Sciences current issue, 2014

Seep sediments are dominated by intensive microbial sulfate reduction coupled to the anaerobic oxidation of methane (AOM). Through geochemical measurements of incubation experiments with methane seep sediments collected from Hydrate Ridge, we provide insight into the role of iron oxides in ...

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Predicting the outcomes of treatment to eradicate the latent reservoir for HIV-1 [Applied Mathematics]

16-09-2014 | Alison L. Hill; Daniel I. S. Rosenbloom; Feng Fu; Martin A. Nowak; Robert F. Siliciano, Proceedings of the National Academy of Sciences current issue, 2014

Massive research efforts are now underway to develop a cure for HIV infection, allowing patients to discontinue lifelong combination antiretroviral therapy (ART). New latency-reversing agents (LRAs) may be able to purge the persistent reservoir of latent virus in resting memory CD4+ T cells, but ...

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The class III ribonucleotide reductase from Neisseria bacilliformis can utilize thioredoxin as a reductant [Biochemistry]

09-09-2014 | Yifeng Wei; Michael A. Funk; Leonardo A. Rosado; Jiyeon Baek; Catherine L. Drennan; JoAnne Stubbe, Proceedings of the National Academy of Sciences current issue, 2014

The class III anaerobic ribonucleotide reductases (RNRs) studied to date couple the reduction of ribonucleotides to deoxynucleotides with the oxidation of formate to CO2. Here we report the cloning and heterologous expression of the Neisseria bacilliformis class III RNR and show that it can ...

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Characterizing the proton loading site in cytochrome c oxidase [Biophysics and Computational Biology]

26-08-2014 | Jianxun Lu; M. R. Gunner, Proceedings of the National Academy of Sciences current issue, 2014

Cytochrome c oxidase (CcO) uses the energy released by reduction of O2 to H2O to drive eight charges from the high pH to low pH side of the membrane, increasing the electrochemical gradient. Four electrons and protons are used for chemistry, while four more protons are pumped. Proton pumping ...

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RABbing cancer the wrong way [Medical Sciences]

05-08-2014 | Prashant K. Khade; Paraskevi Giannakakou, Proceedings of the National Academy of Sciences current issue, 2014

Hypoxia, a reduction in the normal level of tissue oxygen tension, is a common characteristic of solid tumors, endowing them with malignant, aggressive, and treatment-refractory properties (1, 2). The family of hypoxia-inducible heterodimeric transcription factors (HIFs) (3) mediates, at large, ...

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GABAB autoreceptor-mediated cell type-specific reduction of inhibition in epileptic mice [Neuroscience]

10-09-2013 | Tamar Dugladze; Nino Maziashvili; Christoph Börgers; Shalva Gurgenidze; Ute Häussler; Aline Winkelmann; Carola A. Ha ..., Proceedings of the National Academy of Sciences current issue, 2013

GABAB receptors (GABABRs) mediate slow inhibitory effects on neuronal excitability and synaptic transmission in the brain. However, the GABABR agonist baclofen can also promote excitability and seizure generation in human patients and animals models. Here we show that baclofen has ...

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let-7 and miR-140 microRNAs coordinately regulate skeletal development [Developmental Biology]

27-08-2013 | Garyfallia Papaioannou; Jennifer B. Inloes; Yukio Nakamura; Elena Paltrinieri; Tatsuya Kobayashi, Proceedings of the National Academy of Sciences current issue, 2013

MicroRNAs (miRNAs) play critical roles in multiple processes of skeletal development. A global reduction of miRNAs in growth plate chondrocytes results in defects in both proliferation and differentiation; however, specific microRNAs responsible for these defects have not been identified. In this ...

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