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450 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

Molecular ruler determines needle length for the Salmonella Spi-1 injectisome [Microbiology]

31-Mar-2015 | Daniel H. Wee; Kelly T. Hughes, Proceedings of the National Academy of Sciences current issue, 2015

The type-III secretion (T3S) systems of bacteria are part of self-assembling nanomachines: the bacterial flagellum that enables cells to propel themselves through liquid and across hydrated surfaces, and the injectisome that delivers pathogenic effector proteins into eukaryotic host cells. ...

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New aspect of plant-rhizobia interaction: Alkaloid biosynthesis in Crotalaria depends on nodulation [Plant Biology]

31-Mar-2015 | Simon Irmer; Nora Podzun; Dorothee Langel; Franziska Heidemann; Elisabeth Kaltenegger; Brigitte Schemmerling; Christ ..., Proceedings of the National Academy of Sciences current issue, 2015

Infection of legume hosts by rhizobial bacteria results in the formation of a specialized organ, the nodule, in which atmospheric nitrogen is reduced to ammonia. Nodulation requires the reprogramming of the plant cell, allowing the microsymbiont to enter the plant tissue in a highly controlled ...

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AcrB drug-binding pocket substitution confers clinically relevant resistance and altered substrate specificity [Microbiology]

17-Mar-2015 | Jessica M. A. Blair; Vassiliy N. Bavro; Vito Ricci; Niraj Modi; Pierpaolo Cacciotto; Ulrich Kleinekathӧfer; Paolo Ru ..., Proceedings of the National Academy of Sciences current issue, 2015

The incidence of multidrug-resistant bacterial infections is increasing globally and the need to understand the underlying mechanisms is paramount to discover new therapeutics. The efflux pumps of Gram-negative bacteria have a broad substrate range and transport antibiotics out of the bacterium, ...

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Thermodynamic mechanism for inhibition of lactose permease by the phosphotransferase protein IIAGlc [Biochemistry]

24-Feb-2015 | Parameswaran Hariharan; Dhandayuthapani Balasubramaniam; Alan Peterkofsky; H. Ronald Kaback; Lan Guan, Proceedings of the National Academy of Sciences current issue, 2015

In a variety of bacteria, the phosphotransferase protein IIAGlc plays a key regulatory role in catabolite repression in addition to its role in the vectorial phosphorylation of glucose catalyzed by the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). The lactose permease (LacY) ...

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Quorum sensing and policing of Pseudomonas aeruginosa social cheaters [Microbiology]

17-Feb-2015 | Meizhen Wang; Amy L. Schaefer; Ajai A. Dandekar; E. Peter Greenberg, Proceedings of the National Academy of Sciences current issue, 2015

The bacterium Pseudomonas aeruginosa is an opportunistic human pathogen that uses a quorum sensing signal cascade to activate expression of dozens of genes when sufficient population densities have been reached. Quorum sensing controls production of several key virulence factors, including ...

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An HD-domain phosphodiesterase mediates cooperative hydrolysis of c-di-AMP to affect bacterial growth and virulence [Microbiology]

17-Feb-2015 | TuAnh Ngoc Huynh; Shukun Luo; Daniel Pensinger; John-Demian Sauer; Liang Tong; Joshua J. Woodward, Proceedings of the National Academy of Sciences current issue, 2015

The nucleotide cyclic di-3′,5′- adenosine monophosphate (c-di-AMP) was recently identified as an essential and widespread second messenger in bacterial signaling. Among c-di-AMP–producing bacteria, altered nucleotide levels result in several physiological defects and attenuated virulence. Thus, a ...

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Proton-coupled electron transfer and the role of water molecules in proton pumping by cytochrome c oxidase [Biophysics and Computational Biology]

17-Feb-2015 | Vivek Sharma; Giray Enkavi; Ilpo Vattulainen; Tomasz Róg; Mårten Wikström, Proceedings of the National Academy of Sciences current issue, 2015

Molecular oxygen acts as the terminal electron sink in the respiratory chains of aerobic organisms. Cytochrome c oxidase in the inner membrane of mitochondria and the plasma membrane of bacteria catalyzes the reduction of oxygen to water, and couples the free energy of the reaction to proton ...

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Inhibition of the {beta}-barrel assembly machine by a peptide that binds BamD [Biochemistry]

17-Feb-2015 | Christine L. Hagan; Joseph S. Wzorek; Daniel Kahne, Proceedings of the National Academy of Sciences current issue, 2015

The protein complex that assembles integral membrane β-barrel proteins in the outer membranes of Gram-negative bacteria is an attractive target in the development of new antibiotics. This complex, the β-barrel assembly machine (Bam), contains two essential proteins, BamA and BamD. We have ...

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Noncanonical coproporphyrin-dependent bacterial heme biosynthesis pathway that does not use protoporphyrin [Microbiology]

17-Feb-2015 | Harry A. Dailey; Svetlana Gerdes; Tamara A. Dailey; Joseph S. Burch; John D. Phillips, Proceedings of the National Academy of Sciences current issue, 2015

It has been generally accepted that biosynthesis of protoheme (heme) uses a common set of core metabolic intermediates that includes protoporphyrin. Herein, we show that the Actinobacteria and Firmicutes (high-GC and low-GC Gram-positive bacteria) are unable to synthesize protoporphyrin. Instead, ...

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Differential RNA-seq of Vibrio cholerae identifies the VqmR small RNA as a regulator of biofilm formation [Microbiology]

17-Feb-2015 | Kai Papenfort; Konrad U. Förstner; Jian-Ping Cong; Cynthia M. Sharma; Bonnie L. Bassler, Proceedings of the National Academy of Sciences current issue, 2015

Quorum sensing (QS) is a process of cell-to-cell communication that enables bacteria to transition between individual and collective lifestyles. QS controls virulence and biofilm formation in Vibrio cholerae, the causative agent of cholera disease. Differential RNA sequencing (RNA-seq) of ...

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