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339 Newest Publications in proceedings of the national academy of sciences current issue
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matching the following criteria
Central role of liver in anticancer and radioprotective activities of Toll-like receptor 5 agonist [Medical Sciences]
14-05-2013 | Lyudmila G. Burdelya; Craig M. Brackett; Bojidar Kojouharov; Ilya I. Gitlin; Katerina I. Leonova; Anatoli S. Gleiber ..., Proceedings of the National Academy of Sciences current issue, 2013
Vertebrate Toll-like receptor 5 (TLR5) recognizes bacterial flagellin proteins and activates innate immune responses to motile bacteria. In addition, activation of TLR5 signaling can inhibit growth of TLR5-expressing tumors and protect normal tissues from radiation and ischemia-reperfusion ...
Activation of heme biosynthesis by a small molecule that is toxic to fermenting Staphylococcus aureus [Microbiology]
14-05-2013 | Laura A. Mike; Brendan F. Dutter; Devin L. Stauff; Jessica L. Moore; Nicholas P. Vitko; Olusegun Aranmolate; Thomas ..., Proceedings of the National Academy of Sciences current issue, 2013
Staphylococcus aureus is a significant infectious threat to global public health. Acquisition or synthesis of heme is required for S. aureus to capture energy through respiration, but an excess of this critical cofactor is toxic to bacteria. S. aureus employs the heme sensor system (HssRS) to ...
Conserved glycolipid termini in capsular polysaccharides synthesized by ATP-binding cassette transporter-dependent pathways in Gram-negative pathogens [Microbiology]
07-05-2013 | Lisa M. Willis; Jacek Stupak; Michele R. Richards; Todd L. Lowary; Jianjun Li; Chris Whitfield, Proceedings of the National Academy of Sciences current issue, 2013
Bacterial capsules are surface layers made of long-chain polysaccharides. They are anchored to the outer membrane of many Gram-negative bacteria, including pathogens such as Escherichia coli, Neisseria meningitidis, Haemophilus influenzae, and Pasteurella multocida. Capsules protect pathogens ...
Controlling electron transfer at the microbe-mineral interface [Microbiology]
07-05-2013 | David J. Richardson; Julea N. Butt; Thomas A. Clarke, Proceedings of the National Academy of Sciences current issue, 2013
Remarkably, many bacteria live and thrive in the earth’s subsurface by respiring extracellular insoluble minerals. Okamato et al. (1) in PNAS report how this process may be accelerated by the presence of flavins that bind as cofactors to electron transport proteins on the cell surface that ...
Antagonistic self-sensing and mate-sensing signaling controls antibiotic-resistance transfer [Systems Biology]
23-04-2013 | Anushree Chatterjee; Laura C. C. Cook; Che-Chi Shu; Yuqing Chen; Dawn A. Manias; Doraiswami Ramkrishna; Gary M. Dunn ..., Proceedings of the National Academy of Sciences current issue, 2013
Conjugation is one of the most common ways bacteria acquire antibiotic resistance, contributing to the emergence of multidrug-resistant “superbugs.” Bacteria of the genus Enterococcus faecalis are highly antibiotic-resistant nosocomial pathogens that use the mechanism of conjugation to spread ...
Rhs proteins from diverse bacteria mediate intercellular competition [Microbiology]
23-04-2013 | Sanna Koskiniemi; James G. Lamoureux; Kiel C. Nikolakakis; Claire t'Kint de Roodenbeke; Michael D. Kaplan; David A. ..., Proceedings of the National Academy of Sciences current issue, 2013
Rearrangement hotspot (Rhs) and related YD-peptide repeat proteins are widely distributed in bacteria and eukaryotes, but their functions are poorly understood. Here, we show that Gram-negative Rhs proteins and the distantly related wall-associated protein A (WapA) from Gram-positive bacteria ...
Substrate selectivity in arginine-dependent acid resistance in enteric bacteria [Biochemistry]
09-04-2013 | Ming-Feng Tsai; Christopher Miller, Proceedings of the National Academy of Sciences current issue, 2013
To successfully colonize the human gut, enteric bacteria must activate acid resistance systems to survive the extreme acidity (pH 1.5–3.5) of the stomach. The antiporter AdiC is the master orchestrator of the arginine-dependent system. Upon acid shock, it imports extracellular arginine (Arg) ...
Cell-free study of F plasmid partition provides evidence for cargo transport by a diffusion-ratchet mechanism [Cell Biology]
09-04-2013 | Anthony G. Vecchiarelli; Ling Chin Hwang; Kiyoshi Mizuuchi, Proceedings of the National Academy of Sciences current issue, 2013
Increasingly diverse types of cargo are being found to be segregated and positioned by ParA-type ATPases. Several minimalistic systems described in bacteria are self-organizing and are known to affect the transport of plasmids, protein machineries, and chromosomal loci. One well-studied model ...
Substrate selectivity in glutamate-dependent acid resistance in enteric bacteria [Biochemistry]
09-04-2013 | Ming-Feng Tsai; Patrick McCarthy; Christopher Miller, Proceedings of the National Academy of Sciences current issue, 2013
The bacterial antiporter GadC plays a central role in the glutamate (Glu)-dependent acid resistance system, which protects enteric bacteria against the extreme acidity of the human stomach. Upon acid shock, GadC imports Glu into the cytoplasm, where Glu decarboxylases consume a cytoplasmic ...
How bacteria survive an acid trip [Biochemistry]
02-04-2013 | Karan S. Hingorani; Lila M. Gierasch, Proceedings of the National Academy of Sciences current issue, 2013
The evolutionary pressure to populate rewarding niches can require organisms to survive high-risk environments. For bacteria that inhabit the nutrient-rich human gut, whether they are our friends or foes, the trip through the stomach requires clever strategies to survive harsh, low-pH ...
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