My watch list
my.chemeurope.com  
Login  

533 Newest Publications in proceedings of the national academy of sciences current issue

rss
matching the following criteria

Aminoacyl {beta}-naphthylamides as substrates and modulators of AcrB multidrug efflux pump [Microbiology]

02-Feb-2016 | Alfred D. Kinana; Attilio V. Vargiu; Thithiwat May; Hiroshi Nikaido, Proceedings of the National Academy of Sciences current issue, 2016

Efflux pumps of the resistance-nodulation division superfamily, such as AcrB, make a major contribution to multidrug resistance in Gram-negative bacteria. Inhibitors of such pumps would improve the efficacy of antibiotics, and ameliorate the crisis in health care caused by the prevalence of ...

more

Molecular mechanism of viomycin inhibition of peptide elongation in bacteria [Biochemistry]

26-Jan-2016 | Mikael Holm; Anneli Borg; Måns Ehrenberg; Suparna Sanyal, Proceedings of the National Academy of Sciences current issue, 2016

Viomycin is a tuberactinomycin antibiotic essential for treating multidrug-resistant tuberculosis. It inhibits bacterial protein synthesis by blocking elongation factor G (EF-G) catalyzed translocation of messenger RNA on the ribosome. Here we have clarified the molecular aspects of viomycin ...

more

Bacterial RNA polymerase can retain {sigma}70 throughout transcription [Biochemistry]

19-Jan-2016 | Timothy T. Harden; Christopher D. Wells; Larry J. Friedman; Robert Landick; Ann Hochschild; Jane Kondev; Jeff Gelles, Proceedings of the National Academy of Sciences current issue, 2016

Production of a messenger RNA proceeds through sequential stages of transcription initiation and transcript elongation and termination. During each of these stages, RNA polymerase (RNAP) function is regulated by RNAP-associated protein factors. In bacteria, RNAP-associated σ factors are strictly ...

more

Cross-talk among flesh-eating Aeromonas hydrophila strains in mixed infection leading to necrotizing fasciitis [Microbiology]

19-Jan-2016 | Duraisamy Ponnusamy; Elena V. Kozlova; Jian Sha; Tatiana E. Erova; Sasha R. Azar; Eric C. Fitts; Michelle L. Kirtley ..., Proceedings of the National Academy of Sciences current issue, 2016

Necrotizing fasciitis (NF) caused by flesh-eating bacteria is associated with high case fatality. In an earlier study, we reported infection of an immunocompetent individual with multiple strains of Aeromonas hydrophila (NF1–NF4), the latter three constituted a clonal group whereas NF1 was ...

more

A cell wall damage response mediated by a sensor kinase/response regulator pair enables beta-lactam tolerance [Microbiology]

12-Jan-2016 | Tobias Dörr; Laura Alvarez; Fernanda Delgado; Brigid M. Davis; Felipe Cava; Matthew K. Waldor, Proceedings of the National Academy of Sciences current issue, 2016

The bacterial cell wall is critical for maintenance of cell shape and survival. Following exposure to antibiotics that target enzymes required for cell wall synthesis, bacteria typically lyse. Although several cell envelope stress response systems have been well described, there is little ...

more

Zinc-dependent mechanical properties of Staphylococcus aureus biofilm-forming surface protein SasG [Microbiology]

12-Jan-2016 | Cécile Formosa-Dague; Pietro Speziale; Timothy J. Foster; Joan A. Geoghegan; Yves F. Dufrêne, Proceedings of the National Academy of Sciences current issue, 2016

Staphylococcus aureus surface protein SasG promotes cell–cell adhesion during the accumulation phase of biofilm formation, but the molecular basis of this interaction remains poorly understood. Here, we unravel the mechanical properties of SasG on the surface of living bacteria, that is, in its ...

more

Oxidization without substrate unfolding triggers proteolysis of the peroxide-sensor, PerR [Biochemistry]

05-Jan-2016 | Bo-Eun Ahn; Tania A. Baker, Proceedings of the National Academy of Sciences current issue, 2016

Peroxide operon regulator (PerR) is a broadly conserved hydrogen peroxide sensor in bacteria, and oxidation of PerR at its regulatory metal-binding site is considered irreversible. Here, we tested whether this oxidation specifically targets PerR for proteolysis. We find that oxidizing conditions ...

more

Unexpected features of the dark proteome [Biophysics and Computational Biology]

29-Dec-2015 | Nelson Perdigão; Julian Heinrich; Christian Stolte; Kenneth S. Sabir; Michael J. Buckley; Bruce Tabor; Beth Signal; ..., Proceedings of the National Academy of Sciences current issue, 2015

We surveyed the “dark” proteome–that is, regions of proteins never observed by experimental structure determination and inaccessible to homology modeling. For 546,000 Swiss-Prot proteins, we found that 44–54% of the proteome in eukaryotes and viruses was dark, compared with only ∼14% in archaea ...

more

Glycan:glycan interactions: High affinity biomolecular interactions that can mediate binding of pathogenic bacteria to host cells [Microbiology]

29-Dec-2015 | Christopher J. Day; Elizabeth N. Tran; Evgeny A. Semchenko; Greg Tram; Lauren E. Hartley-Tassell; Preston S. K. Ng; ..., Proceedings of the National Academy of Sciences current issue, 2015

Cells from all domains of life express glycan structures attached to lipids and proteins on their surface, called glycoconjugates. Cell-to-cell contact mediated by glycan:glycan interactions have been considered to be low-affinity interactions that precede high-affinity protein–glycan or ...

more

Gut bacteria mediate aggregation in the German cockroach [Chemistry]

22-Dec-2015 | Ayako Wada-Katsumata; Ludek Zurek; Godfrey Nalyanya; Wendell L. Roelofs; Aijun Zhang; Coby Schal, Proceedings of the National Academy of Sciences current issue, 2015

Aggregation of the German cockroach, Blattella germanica, is regulated by fecal aggregation agents (pheromones), including volatile carboxylic acids (VCAs). We demonstrate that the gut microbial community contributes to production of these semiochemicals. Chemical analysis of the fecal extract of ...

more

Page 1 From 54
Subscribe to e-mail updates relating to your search

You will receive via e-mail the latest search results matching your search criteria. This service is free of charge and can be cancelled at any time.

Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE