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804 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

A simple theoretical model goes a long way in explaining complex behavior in protein folding [Biophysics and Computational Biology]

11-11-2014 | Victor Muñoz, Proceedings of the National Academy of Sciences current issue, 2014

Understanding how natural proteins fold spontaneously onto their specific, biologically functional 3D structures is both a fascinating fundamental problem in modern biochemistry and a necessary step toward developing technologies for protein engineering and designing protein-based nanodevices. ...

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The mechanism of Torsin ATPase activation [Biochemistry]

11-11-2014 | Rebecca S. H. Brown; Chenguang Zhao; Anna R. Chase; Jimin Wang; Christian Schlieker, Proceedings of the National Academy of Sciences current issue, 2014

Torsins are membrane-associated ATPases whose activity is dependent on two activating cofactors, lamina-associated polypeptide 1 (LAP1) and luminal domain-like LAP1 (LULL1). The mechanism by which these cofactors regulate Torsin activity has so far remained elusive. In this study, we identify a ...

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Selective allosteric coupling in core chemotaxis signaling complexes [Biochemistry]

11-11-2014 | Mingshan Li; Gerald L. Hazelbauer, Proceedings of the National Academy of Sciences current issue, 2014

Bacterial chemotaxis is mediated by signaling complexes that sense chemical gradients and direct bacteria to favorable environments by controlling a histidine kinase as a function of chemoreceptor ligand occupancy. Core signaling complexes contain two trimers of transmembrane chemoreceptor ...

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Xylose phosphorylation functions as a molecular switch to regulate proteoglycan biosynthesis [Biochemistry]

04-11-2014 | Jianzhong Wen; Junyu Xiao; Meghdad Rahdar; Biswa P. Choudhury; Jixin Cui; Gregory S. Taylor; Jeffrey D. Esko; Jack E ..., Proceedings of the National Academy of Sciences current issue, 2014

Most eukaryotic cells elaborate several proteoglycans critical for transmitting biochemical signals into and between cells. However, the regulation of proteoglycan biosynthesis is not completely understood. We show that the atypical secretory kinase family with sequence similarity 20, member B ...

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An intramolecular lock facilitates folding and stabilizes the tertiary structure of Streptococcus mutans adhesin P1 [Biochemistry]

04-11-2014 | Kyle P. Heim; Paula J. Crowley; Joanna R. Long; Shweta Kailasan; Robert McKenna; L. Jeannine Brady, Proceedings of the National Academy of Sciences current issue, 2014

The cariogenic bacterium Streptococcus mutans uses adhesin P1 to adhere to tooth surfaces, extracellular matrix components, and other bacteria. A composite model of P1 based on partial crystal structures revealed an unusual complex architecture in which the protein forms an elongated hybrid ...

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Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome [Biochemistry]

04-11-2014 | Hongbing Zhang; Lily I. Pao; Aileen Zhou; Arthur D. Brace; Robert Halenbeck; Amy W. Hsu; Thomas L. Bray; Kevin Hesti ..., Proceedings of the National Academy of Sciences current issue, 2014

There are many transmembrane receptor-like proteins whose ligands have not been identified. A strategy for finding ligands when little is known about their tissue source is to screen each extracellular protein individually expressed in an array format by using a sensitive functional readout. ...

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Kinetic evidence against partitioning of the ubiquinone pool and the catalytic relevance of respiratory-chain supercomplexes [Biochemistry]

04-11-2014 | James N. Blaza; Riccardo Serreli; Andrew J. Y. Jones; Khairunnisa Mohammed; Judy Hirst, Proceedings of the National Academy of Sciences current issue, 2014

In mitochondria, four respiratory-chain complexes drive oxidative phosphorylation by sustaining a proton-motive force across the inner membrane that is used to synthesize ATP. The question of how the densely packed proteins of the inner membrane are organized to optimize structure and function ...

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Proteolytic control of neurite outgrowth inhibitor NOGO-A by the cAMP/PKA pathway [Biochemistry]

04-11-2014 | Maria Sepe; Luca Lignitto; Monia Porpora; Rossella Delle Donne; Laura Rinaldi; Giuseppe Belgianni; Gianna Colucci; O ..., Proceedings of the National Academy of Sciences current issue, 2014

Protein kinase A (PKA) controls major aspects of neurite outgrowth and morphogenesis and plays an essential role in synaptic plasticity and memory. However, the molecular mechanism(s) of PKA action on neurite sprouting and activity are still unknown. Here, we report that in response to ...

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Mitochondrial COQ9 is a lipid-binding protein that associates with COQ7 to enable coenzyme Q biosynthesis [Biochemistry]

04-11-2014 | Danielle C. Lohman; Farhad Forouhar; Emily T. Beebe; Matthew S. Stefely; Catherine E. Minogue; Arne Ulbrich; Jonatha ..., Proceedings of the National Academy of Sciences current issue, 2014

Coenzyme Q (CoQ) is an isoprenylated quinone that is essential for cellular respiration and is synthesized in mitochondria by the combined action of at least nine proteins (COQ1–9). Although most COQ proteins are known to catalyze modifications to CoQ precursors, the biochemical role of COQ9 ...

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Structure and activation of a heteromeric protease complex [Biochemistry]

28-10-2014 | Jing Liu; Peter Chien, Proceedings of the National Academy of Sciences current issue, 2014

New drug therapies are needed for treating Mycobacteria tuberculosis infections because strains with multiple drug resistances have arisen that tolerate almost all existing antibiotics (1). Regulated protein degradation is a universal process found in all kingdoms of life and is crucial for ...

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