My watch list
my.chemeurope.com  
Login  

810 Newest Publications in proceedings of the national academy of sciences current issue

rss
matching the following criteria

Molecular determinants of caspase-9 activation by the Apaf-1 apoptosome [Biochemistry]

18-11-2014 | Qi Hu; Di Wu; Wen Chen; Zhen Yan; Chuangye Yan; Tianxi He; Qionglin Liang; Yigong Shi, Proceedings of the National Academy of Sciences current issue, 2014

Autocatalytic activation of an initiator caspase triggers the onset of apoptosis. In dying cells, caspase-9 activation is mediated by a multimeric adaptor complex known as the Apaf-1 apoptosome. The molecular mechanism by which caspase-9 is activated by the Apaf-1 apoptosome remains largely ...

more

Differential gradients of interaction affinities drive efficient targeting and recycling in the GET pathway [Biochemistry]

18-11-2014 | Michael E. Rome; Un Seng Chio; Meera Rao; Harry Gristick; Shu-ou Shan, Proceedings of the National Academy of Sciences current issue, 2014

Efficient and accurate localization of membrane proteins requires a complex cascade of interactions between protein machineries. This requirement is exemplified in the guided entry of tail-anchored (TA) protein (GET) pathway, where the central targeting factor Get3 must sequentially interact with ...

more

c-Abl tyrosine kinase promotes adipocyte differentiation by targeting PPAR-gamma 2 [Biochemistry]

18-11-2014 | Rom Keshet; Zina Bryansker Kraitshtein; Matan Shanzer; Julia Adler; Nina Reuven; Yosef Shaul, Proceedings of the National Academy of Sciences current issue, 2014

Adipocyte differentiation, or adipogenesis, is a complex and highly regulated process. A recent proteomic analysis has predicted that the nonreceptor tyrosine kinase Abelson murine leukemia viral oncogene (c-Abl) is a putative key regulator of adipogenesis, but the underlying mechanism remained ...

more

Correction for Vestergaard et al., Critical roles of isoleucine-364 and adjacent residues in a hydrophobic gate control of phospholipid transport by the mammalian P4-ATPase ATP8A2 [Correction]

18-11-2014 | Proceedings of the National Academy of Sciences current issue, 2014

BIOCHEMISTRY Correction for “Critical roles of isoleucine-364 and adjacent residues in a hydrophobic gate control of phospholipid transport by the mammalian P4-ATPase ATP8A2,” by Anna L. Vestergaard, Jonathan A. Coleman, Thomas Lemmin, Stine A. Mikkelsen, Laurie L. Molday, Bente Vilsen, Robert S. ...

more

Liat1, an arginyltransferase-binding protein whose evolution among primates involved changes in the numbers of its 10-residue repeats [Biochemistry]

18-11-2014 | Christopher S. Brower; Connor E. Rosen; Richard H. Jones; Brandon C. Wadas; Konstantin I. Piatkov; Alexander Varshavsky, Proceedings of the National Academy of Sciences current issue, 2014

The arginyltransferase Ate1 is a component of the N-end rule pathway, which recognizes proteins containing N-terminal degradation signals called N-degrons, polyubiquitylates these proteins, and thereby causes their degradation by the proteasome. At least six isoforms of mouse Ate1 are produced ...

more

Molecular insights into DNA interference by CRISPR-associated nuclease-helicase Cas3 [Biochemistry]

18-11-2014 | Bei Gong; Minsang Shin; Jiali Sun; Che-Hun Jung; Edward L. Bolt; John van der Oost; Jeong-Sun Kim, Proceedings of the National Academy of Sciences current issue, 2014

Mobile genetic elements in bacteria are neutralized by a system based on clustered regularly interspaced short palindromic repeats (CRISPRs) and CRISPR-associated (Cas) proteins. Type I CRISPR-Cas systems use a “Cascade” ribonucleoprotein complex to guide RNA specifically to complementary ...

more

A simple theoretical model goes a long way in explaining complex behavior in protein folding [Biophysics and Computational Biology]

11-11-2014 | Victor Muñoz, Proceedings of the National Academy of Sciences current issue, 2014

Understanding how natural proteins fold spontaneously onto their specific, biologically functional 3D structures is both a fascinating fundamental problem in modern biochemistry and a necessary step toward developing technologies for protein engineering and designing protein-based nanodevices. ...

more

The mechanism of Torsin ATPase activation [Biochemistry]

11-11-2014 | Rebecca S. H. Brown; Chenguang Zhao; Anna R. Chase; Jimin Wang; Christian Schlieker, Proceedings of the National Academy of Sciences current issue, 2014

Torsins are membrane-associated ATPases whose activity is dependent on two activating cofactors, lamina-associated polypeptide 1 (LAP1) and luminal domain-like LAP1 (LULL1). The mechanism by which these cofactors regulate Torsin activity has so far remained elusive. In this study, we identify a ...

more

Selective allosteric coupling in core chemotaxis signaling complexes [Biochemistry]

11-11-2014 | Mingshan Li; Gerald L. Hazelbauer, Proceedings of the National Academy of Sciences current issue, 2014

Bacterial chemotaxis is mediated by signaling complexes that sense chemical gradients and direct bacteria to favorable environments by controlling a histidine kinase as a function of chemoreceptor ligand occupancy. Core signaling complexes contain two trimers of transmembrane chemoreceptor ...

more

Xylose phosphorylation functions as a molecular switch to regulate proteoglycan biosynthesis [Biochemistry]

04-11-2014 | Jianzhong Wen; Junyu Xiao; Meghdad Rahdar; Biswa P. Choudhury; Jixin Cui; Gregory S. Taylor; Jeffrey D. Esko; Jack E ..., Proceedings of the National Academy of Sciences current issue, 2014

Most eukaryotic cells elaborate several proteoglycans critical for transmitting biochemical signals into and between cells. However, the regulation of proteoglycan biosynthesis is not completely understood. We show that the atypical secretory kinase family with sequence similarity 20, member B ...

more

Page 1 From 81
Subscribe to e-mail updates relating to your search

You will receive via e-mail the latest search results matching your search criteria. This service is free of charge and can be cancelled at any time.

Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE