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893 Newest Publications in proceedings of the national academy of sciences current issue

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Structural mechanisms of DNA binding and unwinding in bacterial RecQ helicases [Biochemistry]

07-Apr-2015 | Kelly A. Manthei; Morgan C. Hill; Jordan E. Burke; Samuel E. Butcher; James L. Keck, Proceedings of the National Academy of Sciences current issue, 2015

RecQ helicases unwind remarkably diverse DNA structures as key components of many cellular processes. How RecQ enzymes accommodate different substrates in a unified mechanism that couples ATP hydrolysis to DNA unwinding is unknown. Here, the X-ray crystal structure of the Cronobacter sakazakii ...

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Motion of proximal histidine and structural allosteric transition in soluble guanylate cyclase [Biochemistry]

07-Apr-2015 | Byung-Kuk Yoo; Isabelle Lamarre; Jean-Louis Martin; Fabrice Rappaport; Michel Negrerie, Proceedings of the National Academy of Sciences current issue, 2015

We investigated the changes of heme coordination in purified soluble guanylate cyclase (sGC) by time-resolved spectroscopy in a time range encompassing 11 orders of magnitude (from 1 ps to 0.2 s). After dissociation, NO either recombines geminately to the 4-coordinate (4c) heme (τG1 = 7.5 ps; 97 ...

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SWI/SNF chromatin-remodeling complexes function in noncoding RNA-dependent assembly of nuclear bodies [Biochemistry]

07-Apr-2015 | Tetsuya Kawaguchi; Akie Tanigawa; Takao Naganuma; Yasuyuki Ohkawa; Sylvie Souquere; Gerard Pierron; Tetsuro Hirose, Proceedings of the National Academy of Sciences current issue, 2015

Paraspeckles are subnuclear structures that form around nuclear paraspeckle assembly transcript 1 (NEAT1) long noncoding RNA (lncRNA). Recently, paraspeckles were shown to be functional nuclear bodies involved in stress responses and the development of specific organs. Paraspeckle formation is ...

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A functional role of Rv1738 in Mycobacterium tuberculosis persistence suggested by racemic protein crystallography [Biochemistry]

07-Apr-2015 | Richard D. Bunker; Kalyaneswar Mandal; Ghader Bashiri; Jessica J. Chaston; Bradley L. Pentelute; J. Shaun Lott; Step ..., Proceedings of the National Academy of Sciences current issue, 2015

Protein 3D structure can be a powerful predictor of function, but it often faces a critical roadblock at the crystallization step. Rv1738, a protein from Mycobacterium tuberculosis that is strongly implicated in the onset of nonreplicating persistence, and thereby latent tuberculosis, resisted ...

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Glucocorticoid receptor interacts with PNRC2 in a ligand-dependent manner to recruit UPF1 for rapid mRNA degradation [Biochemistry]

31-Mar-2015 | Hana Cho; Ok Hyun Park; Joori Park; Incheol Ryu; Jeonghan Kim; Jesang Ko; Yoon Ki Kim, Proceedings of the National Academy of Sciences current issue, 2015

Glucocorticoid receptor (GR), which was originally known to function as a nuclear receptor, plays a role in rapid mRNA degradation by acting as an RNA-binding protein. The mechanism by which this process occurs remains unknown. Here, we demonstrate that GR, preloaded onto the 5′UTR of a target ...

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Structural mechanism of sensing long dsRNA via a noncatalytic domain in human oligoadenylate synthetase 3 [Biochemistry]

31-Mar-2015 | Jesse Donovan; Gena Whitney; Sneha Rath; Alexei Korennykh, Proceedings of the National Academy of Sciences current issue, 2015

The mammalian innate immune system uses several sensors of double-stranded RNA (dsRNA) to develop the interferon response. Among these sensors are dsRNA-activated oligoadenylate synthetases (OAS), which produce signaling 2′,5′-linked RNA molecules (2-5A) that activate regulated RNA decay in ...

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Acyl-CoA oxidase complexes control the chemical message produced by Caenorhabditis elegans [Biochemistry]

31-Mar-2015 | Xinxing Zhang; Likui Feng; Satya Chinta; Prashant Singh; Yuting Wang; Joshawna K. Nunnery; Rebecca A. Butcher, Proceedings of the National Academy of Sciences current issue, 2015

Caenorhabditis elegans uses ascaroside pheromones to induce development of the stress-resistant dauer larval stage and to coordinate various behaviors. Peroxisomal β-oxidation cycles are required for the biosynthesis of the fatty acid-derived side chains of the ascarosides. Here we show that ...

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Universal pathway for posttransfer editing reactions: Insights from the crystal structure of TtPheRS with puromycin [Biochemistry]

31-Mar-2015 | Dmitry Tworowski; Liron Klipcan; Moshe Peretz; Nina Moor; Mark G. Safro, Proceedings of the National Academy of Sciences current issue, 2015

At the amino acid binding and recognition step, phenylalanyl-tRNA synthetase (PheRS) faces the challenge of discrimination between cognate phenylalanine and closely similar noncognate tyrosine. Resampling of Tyr-tRNAPhe to PheRS increasing the number of correctly charged tRNA molecules has ...

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Plasmodium falciparum chloroquine resistance transporter is a H+-coupled polyspecific nutrient and drug exporter [Biochemistry]

17-Mar-2015 | Narinobu Juge; Sawako Moriyama; Takaaki Miyaji; Mamiyo Kawakami; Haruka Iwai; Tomoya Fukui; Nathan Nelson; Hiroshi O ..., Proceedings of the National Academy of Sciences current issue, 2015

Extrusion of chloroquine (CQ) from digestive vacuoles through the Plasmodium falciparum CQ resistance transporter (PfCRT) is essential to establish CQ resistance of the malaria parasite. However, the physiological relevance of PfCRT and how CQ-resistant PfCRT gains the ability to transport CQ ...

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Cleavage of amyloid precursor protein by an archaeal presenilin homologue PSH [Biochemistry]

17-Mar-2015 | Shangyu Dang; Shenjie Wu; Jiawei Wang; Hongbo Li; Min Huang; Wei He; Yue-Ming Li; Catherine C. L. Wong; Yigong Shi, Proceedings of the National Academy of Sciences current issue, 2015

Aberrant cleavage of amyloid precursor protein (APP) by γ-secretase contributes to the development of Alzheimer’s disease. More than 200 disease-derived mutations have been identified in presenilin (the catalytic subunit of γ-secretase), making modulation of γ-secretase activity a potentially ...

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