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1,386 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

Human population reduction is not a quick fix for environmental problems [Population Biology]

18-11-2014 | Corey J. A. Bradshaw; Barry W. Brook, Proceedings of the National Academy of Sciences current issue, 2014

The inexorable demographic momentum of the global human population is rapidly eroding Earth’s life-support system. There are consequently more frequent calls to address environmental problems by advocating further reductions in human fertility. To examine how quickly this could lead to a smaller ...

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Putting things in order [Biophysics and Computational Biology]

18-11-2014 | Ning Sun; Hongyu Zhao, Proceedings of the National Academy of Sciences current issue, 2014

Identifying and characterizing dependence among a set of variables (also called features, covariates, and factors) is at the core of statistics. Since the concept of “correlation” was introduced by Sir Francis Galton (1) in the late 1800s, many measures of associations have been proposed to ...

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Halorhodopsin pumps Cl- and bacteriorhodopsin pumps protons by a common mechanism that uses conserved electrostatic interactions [Biophysics and Computational Biology]

18-11-2014 | Yifan Song; M. R. Gunner, Proceedings of the National Academy of Sciences current issue, 2014

Key mutations differentiate the functions of homologous proteins. One example compares the inward ion pump halorhodopsin (HR) and the outward proton pump bacteriorhodopsin (BR). Of the nine essential buried ionizable residues in BR, six are conserved in HR. However, HR changes three BR acids, D85 ...

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K-RasV14I recapitulates Noonan syndrome in mice [Developmental Biology]

18-11-2014 | Isabel Hernández-Porras; Salvatore Fabbiano; Alberto J. Schuhmacher; Alexandra Aicher; Marta Cañamero; Juan Antonio ..., Proceedings of the National Academy of Sciences current issue, 2014

Noonan syndrome (NS) is an autosomal dominant genetic disorder characterized by short stature, craniofacial dysmorphism, and congenital heart defects. NS also is associated with a risk for developing myeloproliferative disorders (MPD), including juvenile myelomonocytic leukemia (JMML). Mutations ...

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Hedgehog-regulated atypical PKC promotes phosphorylation and activation of Smoothened and Cubitus interruptus in Drosophila [Developmental Biology]

11-11-2014 | Kai Jiang; Yajuan Liu; Junkai Fan; Garretson Epperly; Tianyan Gao; Jin Jiang; Jianhang Jia, Proceedings of the National Academy of Sciences current issue, 2014

Smoothened (Smo) is essential for transduction of the Hedgehog (Hh) signal in both insects and vertebrates. Cell surface/cilium accumulation of Smo is thought to play an important role in Hh signaling, but how the localization of Smo is controlled remains poorly understood. In this study, we ...

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A simple theoretical model goes a long way in explaining complex behavior in protein folding [Biophysics and Computational Biology]

11-11-2014 | Victor Muñoz, Proceedings of the National Academy of Sciences current issue, 2014

Understanding how natural proteins fold spontaneously onto their specific, biologically functional 3D structures is both a fascinating fundamental problem in modern biochemistry and a necessary step toward developing technologies for protein engineering and designing protein-based nanodevices. ...

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Antisense COOLAIR mediates the coordinated switching of chromatin states at FLC during vernalization [Plant Biology]

11-11-2014 | Tibor Csorba; Julia I. Questa; Qianwen Sun; Caroline Dean, Proceedings of the National Academy of Sciences current issue, 2014

Long noncoding RNAs (lncRNAs) have been proposed to play important roles in gene regulation. However, their importance in epigenetic silencing and how specificity is determined remain controversial. We have investigated the cold-induced epigenetic switching mechanism involved in the silencing of ...

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A circadian gene expression atlas in mammals: Implications for biology and medicine [Systems Biology]

11-11-2014 | Ray Zhang; Nicholas F. Lahens; Heather I. Ballance; Michael E. Hughes; John B. Hogenesch, Proceedings of the National Academy of Sciences current issue, 2014

To characterize the role of the circadian clock in mouse physiology and behavior, we used RNA-seq and DNA arrays to quantify the transcriptomes of 12 mouse organs over time. We found 43% of all protein coding genes showed circadian rhythms in transcription somewhere in the body, largely in an ...

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Impact of early-stage HIV transmission on treatment as prevention [Population Biology]

11-11-2014 | Kimberly A. Powers; Mirjam E. Kretzschmar; William C. Miller; Myron S. Cohen, Proceedings of the National Academy of Sciences current issue, 2014

Timely HIV treatment improves health (1) and reduces transmission (2). These individual-level benefits of HIV treatment for both clinical and preventive purposes are well established, but several questions remain about the population-level impact of HIV treatment as prevention (3). In PNAS, Eaton ...

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Use of protein cross-linking and radiolytic footprinting to elucidate PsbP and PsbQ interactions within higher plant Photosystem II [Plant Biology]

11-11-2014 | Manjula P. Mummadisetti; Laurie K. Frankel; Henry D. Bellamy; Larry Sallans; Jost S. Goettert; Michal Brylinski; Pat ..., Proceedings of the National Academy of Sciences current issue, 2014

Protein cross-linking and radiolytic footprinting coupled with high-resolution mass spectrometry were used to examine the structure of PsbP and PsbQ when they are bound to Photosystem II. In its bound state, the N-terminal 15-amino-acid residue domain of PsbP, which is unresolved in current ...

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