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1,382 Newest Publications in proceedings of the national academy of sciences current issue

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Hedgehog-regulated atypical PKC promotes phosphorylation and activation of Smoothened and Cubitus interruptus in Drosophila [Developmental Biology]

11-11-2014 | Kai Jiang; Yajuan Liu; Junkai Fan; Garretson Epperly; Tianyan Gao; Jin Jiang; Jianhang Jia, Proceedings of the National Academy of Sciences current issue, 2014

Smoothened (Smo) is essential for transduction of the Hedgehog (Hh) signal in both insects and vertebrates. Cell surface/cilium accumulation of Smo is thought to play an important role in Hh signaling, but how the localization of Smo is controlled remains poorly understood. In this study, we ...

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A simple theoretical model goes a long way in explaining complex behavior in protein folding [Biophysics and Computational Biology]

11-11-2014 | Victor Muñoz, Proceedings of the National Academy of Sciences current issue, 2014

Understanding how natural proteins fold spontaneously onto their specific, biologically functional 3D structures is both a fascinating fundamental problem in modern biochemistry and a necessary step toward developing technologies for protein engineering and designing protein-based nanodevices. ...

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Antisense COOLAIR mediates the coordinated switching of chromatin states at FLC during vernalization [Plant Biology]

11-11-2014 | Tibor Csorba; Julia I. Questa; Qianwen Sun; Caroline Dean, Proceedings of the National Academy of Sciences current issue, 2014

Long noncoding RNAs (lncRNAs) have been proposed to play important roles in gene regulation. However, their importance in epigenetic silencing and how specificity is determined remain controversial. We have investigated the cold-induced epigenetic switching mechanism involved in the silencing of ...

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A circadian gene expression atlas in mammals: Implications for biology and medicine [Systems Biology]

11-11-2014 | Ray Zhang; Nicholas F. Lahens; Heather I. Ballance; Michael E. Hughes; John B. Hogenesch, Proceedings of the National Academy of Sciences current issue, 2014

To characterize the role of the circadian clock in mouse physiology and behavior, we used RNA-seq and DNA arrays to quantify the transcriptomes of 12 mouse organs over time. We found 43% of all protein coding genes showed circadian rhythms in transcription somewhere in the body, largely in an ...

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Impact of early-stage HIV transmission on treatment as prevention [Population Biology]

11-11-2014 | Kimberly A. Powers; Mirjam E. Kretzschmar; William C. Miller; Myron S. Cohen, Proceedings of the National Academy of Sciences current issue, 2014

Timely HIV treatment improves health (1) and reduces transmission (2). These individual-level benefits of HIV treatment for both clinical and preventive purposes are well established, but several questions remain about the population-level impact of HIV treatment as prevention (3). In PNAS, Eaton ...

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Use of protein cross-linking and radiolytic footprinting to elucidate PsbP and PsbQ interactions within higher plant Photosystem II [Plant Biology]

11-11-2014 | Manjula P. Mummadisetti; Laurie K. Frankel; Henry D. Bellamy; Larry Sallans; Jost S. Goettert; Michal Brylinski; Pat ..., Proceedings of the National Academy of Sciences current issue, 2014

Protein cross-linking and radiolytic footprinting coupled with high-resolution mass spectrometry were used to examine the structure of PsbP and PsbQ when they are bound to Photosystem II. In its bound state, the N-terminal 15-amino-acid residue domain of PsbP, which is unresolved in current ...

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A plausible mechanism, based upon SHORT-ROOT movement, for regulating the number of cortex cell layers in roots [Plant Biology]

11-11-2014 | Shuang Wu; Chin-Mei Lee; Tomomi Hayashi; Simara Price; Fanchon Divol; Sophia Henry; Germain Pauluzzi; Christophe Per ..., Proceedings of the National Academy of Sciences current issue, 2014

Formation of specialized cells and tissues at defined times and in specific positions is essential for the development of multicellular organisms. Often this developmental precision is achieved through intercellular signaling networks, which establish patterns of differential gene expression and ...

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Quantitative proteomics reveals the dynamics of protein changes during Drosophila oocyte maturation and the oocyte-to-embryo transition [Developmental Biology]

11-11-2014 | Iva Kronja; Zachary J. Whitfield; Bingbing Yuan; Kristina Dzeyk; Joanna Kirkpatrick; Jeroen Krijgsveld; Terry L. Orr ..., Proceedings of the National Academy of Sciences current issue, 2014

The onset of development is marked by two major, posttranscriptionally controlled, events: oocyte maturation (release of the prophase I primary arrest) and egg activation (release from the secondary meiotic arrest). Using quantitative mass spectrometry, we previously described proteome remodeling ...

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Membrane-enabled dimerization of the intrinsically disordered cytoplasmic domain of ADAM10 [Biophysics and Computational Biology]

11-11-2014 | Wei Deng; Sungyun Cho; Pin-Chuan Su; Bryan W. Berger; Renhao Li, Proceedings of the National Academy of Sciences current issue, 2014

Intrinsically disordered protein regions are widely distributed in the cytoplasmic domains of many transmembrane receptors. The cytoplasmic domain of a disintegrin and metalloprotease (ADAM)10, a transmembrane metalloprotease mediating ectodomain shedding of diverse membrane proteins, was ...

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Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart [Developmental Biology]

11-11-2014 | Kory J. Lavine; Slava Epelman; Keita Uchida; Kassandra J. Weber; Colin G. Nichols; Joel D. Schilling; David M. Ornit ..., Proceedings of the National Academy of Sciences current issue, 2014

The mechanistic basis for why inflammation is simultaneously both deleterious and essential for tissue repair is not fully understood. Recently, a new paradigm has emerged: Organs are replete with resident macrophages of embryonic origin distinct from monocyte-derived macrophages. This added ...

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