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1,346 Newest Publications in proceedings of the national academy of sciences current issue

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Structure of a PE-PPE-EspG complex from Mycobacterium tuberculosis reveals molecular specificity of ESX protein secretion [Biophysics and Computational Biology]

14-10-2014 | Damian C. Ekiert; Jeffery S. Cox, Proceedings of the National Academy of Sciences current issue, 2014

Nearly 10% of the coding capacity of the Mycobacterium tuberculosis genome is devoted to two highly expanded and enigmatic protein families called PE and PPE, some of which are important virulence/immunogenicity factors and are secreted during infection via a unique alternative secretory system ...

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Evidence for close side-chain packing in an early protein folding intermediate previously assumed to be a molten globule [Biophysics and Computational Biology]

14-10-2014 | Laura E. Rosen; Katelyn B. Connell; Susan Marqusee, Proceedings of the National Academy of Sciences current issue, 2014

The molten globule, a conformational ensemble with significant secondary structure but only loosely packed tertiary structure, has been suggested to be a ubiquitous intermediate in protein folding. However, it is difficult to assess the tertiary packing of transiently populated species to ...

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Structure of nicastrin unveils secrets of {gamma}-secretase [Biophysics and Computational Biology]

14-10-2014 | David M. Bolduc; Michael S. Wolfe, Proceedings of the National Academy of Sciences current issue, 2014

Despite afflicting tens of millions worldwide, Alzheimer’s disease (AD) remains a devastating brain-destroying malady with no effective treatment or cure. A central hallmark of AD is the deposition of amyloid plaques in the brain. These plaques are primarily composed of the amyloid β-peptide ...

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Jake MacMillan: A pioneering chemist in plant biology [Retrospectives]

14-10-2014 | Peter Hedden; Michael H. Beale, Proceedings of the National Academy of Sciences current issue, 2014

Jake MacMillan, who died on May 12, 2014 at the age of 89, was an organic chemist who made an enormous contribution to plant science, particularly in relation to the structure, biosynthesis, and analysis of the gibberellin plant hormones. Jake was born in Wishaw, Scotland, into a lower working ...

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SPX1 is a phosphate-dependent inhibitor of PHOSPHATE STARVATION RESPONSE 1 in Arabidopsis [Plant Biology]

14-10-2014 | María Isabel Puga; Isabel Mateos; Rajulu Charukesi; Zhiye Wang; José M. Franco-Zorrilla; Laura de Lorenzo; María L. ..., Proceedings of the National Academy of Sciences current issue, 2014

To cope with growth in low-phosphate (Pi) soils, plants have evolved adaptive responses that involve both developmental and metabolic changes. PHOSPHATE STARVATION RESPONSE 1 (PHR1) and related transcription factors play a central role in the control of Pi starvation responses (PSRs). How Pi ...

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Solid-to-fluid-like DNA transition in viruses facilitates infection [Biophysics and Computational Biology]

14-10-2014 | Ting Liu; Udom Sae-Ueng; Dong Li; Gabriel C. Lander; Xiaobing Zuo; Bengt Jönsson; Donald Rau; Ivetta Shefer; Alex Ev ..., Proceedings of the National Academy of Sciences current issue, 2014

Releasing the packaged viral DNA into the host cell is an essential process to initiate viral infection. In many double-stranded DNA bacterial viruses and herpesviruses, the tightly packaged genome is hexagonally ordered and stressed in the protein shell, called the capsid. DNA condensed in this ...

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Conformational cycle and ion-coupling mechanism of the Na+/hydantoin transporter Mhp1 [Biophysics and Computational Biology]

14-10-2014 | Kelli Kazmier; Shruti Sharma; Shahidul M. Islam; Benoît Roux; Hassane S. Mchaourab, Proceedings of the National Academy of Sciences current issue, 2014

Ion-dependent transporters of the LeuT-fold couple the uptake of physiologically essential molecules to transmembrane ion gradients. Defined by a conserved 5-helix inverted repeat that encodes common principles of ion and substrate binding, the LeuT-fold has been captured in outward-facing, ...

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Transient conformational fluctuation of TePixD during a reaction [Biophysics and Computational Biology]

14-10-2014 | Kunisato Kuroi; Koji Okajima; Masahiko Ikeuchi; Satoru Tokutomi; Masahide Terazima, Proceedings of the National Academy of Sciences current issue, 2014

Knowledge of the dynamical behavior of proteins, and in particular their conformational fluctuations, is essential to understanding the mechanisms underlying their reactions. Here, transient enhancement of the isothermal partial molar compressibility, which is directly related to the ...

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Effects of geometry and chemistry on hydrophobic solvation [Biophysics and Computational Biology]

14-10-2014 | Robert C. Harris; B. Montgomery Pettitt, Proceedings of the National Academy of Sciences current issue, 2014

Inserting an uncharged van der Waals (vdw) cavity into water disrupts the distribution of water and creates attractive dispersion interactions between the solvent and solute. This free-energy change is the hydrophobic solvation energy (ΔGvdw). Frequently, it is assumed to be linear in the ...

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Beclin-1 deficiency in the murine ovary results in the reduction of progesterone production to promote preterm labor [Developmental Biology]

07-10-2014 | Thomas R. Gawriluk; CheMyong Ko; Xiaoman Hong; Lane K. Christenson; Edmund B. Rucker III, Proceedings of the National Academy of Sciences current issue, 2014

Autophagy is an important cellular process that serves as a companion pathway to the ubiquitin-proteasome system to degrade long-lived proteins and organelles to maintain cell homeostasis. Although initially characterized in yeast, autophagy is being realized as an important regulator of ...

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