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1,949 Newest Publications in proceedings of the national academy of sciences current issue

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Inhibition of translation initiation complex formation by GE81112 unravels a 16S rRNA structural switch involved in P-site decoding [Biophysics and Computational Biology]

19-Apr-2016 | Attilio Fabbretti; Andreas Schedlbauer; Letizia Brandi; Tatsuya Kaminishi; Anna Maria Giuliodori; Raffaella Garofalo ..., Proceedings of the National Academy of Sciences current issue, 2016

In prokaryotic systems, the initiation phase of protein synthesis is governed by the presence of initiation factors that guide the transition of the small ribosomal subunit (30S) from an unlocked preinitiation complex (30S preIC) to a locked initiation complex (30SIC) upon the formation of a ...

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Correction for Springer and Sen, Leukocyte integrin {alpha}L{beta}2 headpiece structures: The {alpha}I domain, the pocket for the internal ligand, and concerted movements of its loops [Correction]

19-Apr-2016 | Proceedings of the National Academy of Sciences current issue, 2016

BIOPHYSICS AND COMPUTATIONAL BIOLOGY Correction for “Leukocyte integrin αLβ2 headpiece structures: The αI domain, the pocket for the internal ligand, and concerted movements of its loops,” by Timothy A. Springer and Mehmet Sen, which appeared in issue 11, March 15, 2016, of Proc Natl Acad Sci USA ...

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Surface force measurements and simulations of mussel-derived peptide adhesives on wet organic surfaces [Biophysics and Computational Biology]

19-Apr-2016 | Zachary A. Levine; Michael V. Rapp; Wei Wei; Ryan Gotchy Mullen; Chun Wu; Gül H. Zerze; Jeetain Mittal; J. Herbert W ..., Proceedings of the National Academy of Sciences current issue, 2016

Translating sticky biological molecules—such as mussel foot proteins (MFPs)—into synthetic, cost-effective underwater adhesives with adjustable nano- and macroscale characteristics requires an intimate understanding of the glue’s molecular interactions. To help facilitate the next generation of ...

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Simultaneous single-molecule epigenetic imaging of DNA methylation and hydroxymethylation [Biophysics and Computational Biology]

19-Apr-2016 | Chun-Xiao Song; Jiajie Diao; Axel T. Brunger; Stephen R. Quake, Proceedings of the National Academy of Sciences current issue, 2016

The modifications 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) are the two major DNA epigenetic modifications in mammalian genomes and play crucial roles in development and pathogenesis. Little is known about the colocalization or potential correlation of these two modifications. ...

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Pathogen receptor discovery with a microfluidic human membrane protein array [Biophysics and Computational Biology]

19-Apr-2016 | Yair Glick; Ya’ara Ben-Ari; Nir Drayman; Michal Pellach; Gregory Neveu; Jim Boonyaratanakornkit; Dorit Avrahami; Shi ..., Proceedings of the National Academy of Sciences current issue, 2016

The discovery of how a pathogen invades a cell requires one to determine which host cell receptors are exploited. This determination is a challenging problem because the receptor is invariably a membrane protein, which represents an Achilles heel in proteomics. We have developed a universal ...

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Radical remodeling of the Y chromosome in a recent radiation of malaria mosquitoes [Applied Biological Sciences]

12-Apr-2016 | Andrew Brantley Hall; Philippos-Aris Papathanos; Atashi Sharma; Changde Cheng; Omar S. Akbari; Lauren Assour; Nichol ..., Proceedings of the National Academy of Sciences current issue, 2016

Y chromosomes control essential male functions in many species, including sex determination and fertility. However, because of obstacles posed by repeat-rich heterochromatin, knowledge of Y chromosome sequences is limited to a handful of model organisms, constraining our understanding of Y ...

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Response of single bacterial cells to stress gives rise to complex history dependence at the population level [Population Biology]

12-Apr-2016 | Roland Mathis; Martin Ackermann, Proceedings of the National Academy of Sciences current issue, 2016

Most bacteria live in ever-changing environments where periods of stress are common. One fundamental question is whether individual bacterial cells have an increased tolerance to stress if they recently have been exposed to lower levels of the same stressor. To address this question, we worked ...

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Measuring and modeling diffuse scattering in protein X-ray crystallography [Biophysics and Computational Biology]

12-Apr-2016 | Andrew H. Van Benschoten; Lin Liu; Ana Gonzalez; Aaron S. Brewster; Nicholas K. Sauter; James S. Fraser; Michael E. Wall, Proceedings of the National Academy of Sciences current issue, 2016

X-ray diffraction has the potential to provide rich information about the structural dynamics of macromolecules. To realize this potential, both Bragg scattering, which is currently used to derive macromolecular structures, and diffuse scattering, which reports on correlations in charge density ...

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Stokes trap for multiplexed particle manipulation and assembly using fluidics [Biophysics and Computational Biology]

12-Apr-2016 | Anish Shenoy; Christopher V. Rao; Charles M. Schroeder, Proceedings of the National Academy of Sciences current issue, 2016

The ability to confine and manipulate single particles and molecules has revolutionized several fields of science. Hydrodynamic trapping offers an attractive method for particle manipulation in free solution without the need for optical, electric, acoustic, or magnetic fields. Here, we develop ...

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GOLDEN 2-LIKE transcription factors for chloroplast development affect ozone tolerance through the regulation of stomatal movement [Plant Biology]

12-Apr-2016 | Yukari Nagatoshi; Nobutaka Mitsuda; Maki Hayashi; Shin-ichiro Inoue; Eiji Okuma; Akihiro Kubo; Yoshiyuki Murata; Mit ..., Proceedings of the National Academy of Sciences current issue, 2016

Stomatal movements regulate gas exchange, thus directly affecting the efficiency of photosynthesis and the sensitivity of plants to air pollutants such as ozone. The GARP family transcription factors GOLDEN 2-LIKE1 (GLK1) and GLK2 have known functions in chloroplast development. Here, we show ...

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