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1,547 Newest Publications in proceedings of the national academy of sciences current issue

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Biology in the Anthropocene: Challenges and insights from young fossil records [Biological Sciences]

21-Apr-2015 | Susan M. Kidwell, Proceedings of the National Academy of Sciences current issue, 2015

With overwhelming evidence of change in habitats, biologists today must assume that few, if any, study areas are natural and that biological variability is superimposed on trends rather than stationary means. Paleobiological data from the youngest sedimentary record, including death assemblages ...

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Molecular determinants of the interactions between proteins and ssDNA [Biophysics and Computational Biology]

21-Apr-2015 | Garima Mishra; Yaakov Levy, Proceedings of the National Academy of Sciences current issue, 2015

ssDNA binding proteins (SSBs) protect ssDNA from chemical and enzymatic assault that can derail DNA processing machinery. Complexes between SSBs and ssDNA are often highly stable, but predicting their structures is challenging, mostly because of the inherent flexibility of ssDNA and the geometric ...

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Time-dependent sequestration of RVE8 by LNK proteins shapes the diurnal oscillation of anthocyanin biosynthesis [Plant Biology]

21-Apr-2015 | Pablo Pérez-García; Yuan Ma; Marcelo J. Yanovsky; Paloma Mas, Proceedings of the National Academy of Sciences current issue, 2015

Circadian clocks sustain 24-h rhythms in physiology and metabolism that are synchronized with the day/night cycle. In plants, the regulatory network responsible for the generation of rhythms has been broadly investigated over the past years. However, little is known about the intersecting ...

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Tryptophan-independent auxin biosynthesis contributes to early embryogenesis in Arabidopsis [Plant Biology]

14-Apr-2015 | Bing Wang; Jinfang Chu; Tianying Yu; Qian Xu; Xiaohong Sun; Jia Yuan; Guosheng Xiong; Guodong Wang; Yonghong Wang; J ..., Proceedings of the National Academy of Sciences current issue, 2015

The phytohormone auxin regulates nearly all aspects of plant growth and development. Tremendous achievements have been made in elucidating the tryptophan (Trp)-dependent auxin biosynthetic pathway; however, the genetic evidence, key components, and functions of the Trp-independent pathway remain ...

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Force-induced on-rate switching and modulation by mutations in gain-of-function von Willebrand diseases [Biophysics and Computational Biology]

14-Apr-2015 | Jongseong Kim; Nathan E. Hudson; Timothy A. Springer, Proceedings of the National Academy of Sciences current issue, 2015

Mutations in the ultralong vascular protein von Willebrand factor (VWF) cause the common human bleeding disorder, von Willebrand disease (VWD). The A1 domain in VWF binds to glycoprotein Ibα (GPIbα) on platelets, in a reaction triggered, in part, by alterations in flow during bleeding. ...

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Analysis of cell division patterns in the Arabidopsis shoot apical meristem [Plant Biology]

14-Apr-2015 | Bruce E. Shapiro; Cory Tobin; Eric Mjolsness; Elliot M. Meyerowitz, Proceedings of the National Academy of Sciences current issue, 2015

The stereotypic pattern of cell shapes in the Arabidopsis shoot apical meristem (SAM) suggests that strict rules govern the placement of new walls during cell division. When a cell in the SAM divides, a new wall is built that connects existing walls and divides the cytoplasm of the daughter ...

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ERAP1 biology and assessment in Ankylosing Spondylitis [Biological Sciences]

14-Apr-2015 | Philip C. Robinson; Matthew A. Brown, Proceedings of the National Academy of Sciences current issue, 2015

We read with interest the work of Reeves et al. on endoplasmic reticulum aminopeptidase 1 (ERAP1) haplotypes found in Ankylosing Spondylitis (AS), and have several concerns about the study and its conclusions (1). Reeves et al. (1) claim, on the basis of sequence data from 19 cases and 17 ...

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Hedgehog signaling activates a positive feedback mechanism involving insulin-like growth factors to induce osteoblast differentiation [Developmental Biology]

14-Apr-2015 | Yu Shi; Jianquan Chen; Courtney M. Karner; Fanxin Long, Proceedings of the National Academy of Sciences current issue, 2015

Hedgehog (Hh) signaling is essential for osteoblast differentiation in the endochondral skeleton during embryogenesis. However, the molecular mechanism underlying the osteoblastogenic role of Hh is not completely understood. Here, we report that Hh markedly induces the expression of insulin-like ...

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Plant nanobionic materials with a giant temperature response mediated by pectin-Ca2+ [Plant Biology]

14-Apr-2015 | Raffaele Di Giacomo; Chiara Daraio; Bruno Maresca, Proceedings of the National Academy of Sciences current issue, 2015

Conventional approaches to create biomaterials rely on reverse engineering of biological structures, on biomimicking, and on bioinspiration. Plant nanobionics is a recent approach to engineer new materials combining plant organelles with synthetic nanoparticles to enhance, for example, ...

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Clustering of mammalian Hox genes with other H3K27me3 targets within an active nuclear domain [Developmental Biology]

14-Apr-2015 | Maxence Vieux-Rochas; Pierre J. Fabre; Marion Leleu; Denis Duboule; Daan Noordermeer, Proceedings of the National Academy of Sciences current issue, 2015

Embryogenesis requires the precise activation and repression of many transcriptional regulators. The Polycomb group proteins and the associated H3K27me3 histone mark are essential to maintain the inactive state of many of these genes. Mammalian Hox genes are targets of Polycomb proteins and form ...

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