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1,489 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

Root surface as a frontier for plant microbiome research [Plant Biology]

24-Feb-2015 | Marcel G. A. van der Heijden; Klaus Schlaeppi, Proceedings of the National Academy of Sciences current issue, 2015

Plants associate—analogous to animals or us humans—with a multitude of microorganisms, which collectively function as a microbiome. A major discovery of the last decade is that numerous organisms of a microbiome (aka microbiota) are not unpretentious background actors. Instead, some microbiota ...

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Localizing a gate in CFTR [Biophysics and Computational Biology]

24-Feb-2015 | Xiaolong Gao; Tzyh-Chang Hwang, Proceedings of the National Academy of Sciences current issue, 2015

Experimental and computational studies have painted a picture of the chloride permeation pathway in cystic fibrosis transmembrane conductance regulator (CFTR) as a short narrow tunnel flanked by wider inner and outer vestibules. Although these studies also identified a number of transmembrane ...

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Gold-silica quantum rattles for multimodal imaging and therapy [Medical Sciences]

17-Feb-2015 | Mathew Hembury; Ciro Chiappini; Sergio Bertazzo; Tammy L. Kalber; Glenna L. Drisko; Olumide Ogunlade; Simon Walker-S ..., Proceedings of the National Academy of Sciences current issue, 2015

Gold quantum dots exhibit distinctive optical and magnetic behaviors compared with larger gold nanoparticles. However, their unfavorable interaction with living systems and lack of stability in aqueous solvents has so far prevented their adoption in biology and medicine. Here, a simple synthetic ...

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Correction for Das et al., Structure of CrgA, a cell division structural and regulatory protein from Mycobacterium tuberculosis, in lipid bilayers [Correction]

17-Feb-2015 | Proceedings of the National Academy of Sciences current issue, 2015

BIOPHYSICS AND COMPUTATIONAL BIOLOGY Correction for “Structure of CrgA, a cell division structural and regulatory protein from Mycobacterium tuberculosis, in lipid bilayers,” by Nabanita Das, Jian Dai, Ivan Hung, Malini R. Rajagopalan, Huan-Xiang Zhou, and Timothy A. Cross, which appeared in ...

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An early secretory pathway mediated by GNOM-LIKE 1 and GNOM is essential for basal polarity establishment in Arabidopsis thaliana [Plant Biology]

17-Feb-2015 | Siamsa M. Doyle; Ash Haeger; Thomas Vain; Adeline Rigal; Corrado Viotti; Małgorzata Łangowska; Qian Ma; Jiří Friml; ..., Proceedings of the National Academy of Sciences current issue, 2015

Spatial regulation of the plant hormone indole-3-acetic acid (IAA, or auxin) is essential for plant development. Auxin gradient establishment is mediated by polarly localized auxin transporters, including PIN-FORMED (PIN) proteins. Their localization and abundance at the plasma membrane are ...

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Single liposome analysis of peptide translocation by the ABC transporter TAPL [Biophysics and Computational Biology]

17-Feb-2015 | Tina Zollmann; Gemma Moiset; Franz Tumulka; Robert Tampé; Bert Poolman; Rupert Abele, Proceedings of the National Academy of Sciences current issue, 2015

ATP-binding cassette (ABC) transporters use ATP to drive solute transport across biological membranes. Members of this superfamily have crucial roles in cell physiology, and some of the transporters are linked to severe diseases. However, understanding of the transport mechanism, especially of ...

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Phylogenomics with paralogs [Biophysics and Computational Biology]

17-Feb-2015 | Marc Hellmuth; Nicolas Wieseke; Marcus Lechner; Hans-Peter Lenhof; Martin Middendorf; Peter F. Stadler, Proceedings of the National Academy of Sciences current issue, 2015

Phylogenomics heavily relies on well-curated sequence data sets that comprise, for each gene, exclusively 1:1 orthologos. Paralogs are treated as a dangerous nuisance that has to be detected and removed. We show here that this severe restriction of the data sets is not necessary. Building upon ...

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CryoEM and mutagenesis reveal that the smallest capsid protein cements and stabilizes Kaposi's sarcoma-associated herpesvirus capsid [Biophysics and Computational Biology]

17-Feb-2015 | Xinghong Dai; Danyang Gong; Yuchen Xiao; Ting-Ting Wu; Ren Sun; Z. Hong Zhou, Proceedings of the National Academy of Sciences current issue, 2015

With just one eighth the size of the major capsid protein (MCP), the smallest capsid protein (SCP) of human tumor herpesviruses—Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV)—is vital to capsid assembly, yet its mechanism of action is unknown. Here, by cryoEM of KSHV ...

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Adipogenesis and epicardial adipose tissue: A novel fate of the epicardium induced by mesenchymal transformation and PPAR{gamma} activation [Developmental Biology]

17-Feb-2015 | Yukiko Yamaguchi; Susana Cavallero; Michaela Patterson; Hua Shen; Jian Xu; S. Ram Kumar; Henry M. Sucov, Proceedings of the National Academy of Sciences current issue, 2015

The hearts of many mammalian species are surrounded by an extensive layer of fat called epicardial adipose tissue (EAT). The lineage origins and determinative mechanisms of EAT development are unclear, in part because mice and other experimentally tractable model organisms are thought to not have ...

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Auxin binding protein 1 (ABP1) is not required for either auxin signaling or Arabidopsis development [Plant Biology]

17-Feb-2015 | Yangbin Gao; Yi Zhang; Da Zhang; Xinhua Dai; Mark Estelle; Yunde Zhao, Proceedings of the National Academy of Sciences current issue, 2015

Auxin binding protein 1 (ABP1) has been studied for decades. It has been suggested that ABP1 functions as an auxin receptor and has an essential role in many developmental processes. Here we present our unexpected findings that ABP1 is neither required for auxin signaling nor necessary for plant ...

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