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1,087 Newest Publications in proceedings of the national academy of sciences current issue
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matching the following criteria
Expression of TEX101, regulated by ACE, is essential for the production of fertile mouse spermatozoa [Developmental Biology]
14-05-2013 | Yoshitaka Fujihara; Keizo Tokuhiro; Yuko Muro; Gen Kondoh; Yoshihiko Araki; Masahito Ikawa; Masaru Okabe, Proceedings of the National Academy of Sciences current issue, 2013
Formation of spermatozoa of normal shape, number, and motility is insufficient for the male siring of pups. The spermatozoa must be accompanied by sound fertilizing ability. We found that males with disrupted testis-expressed gene 101 (Tex101) produce normal-looking but ...
p63-expressing cells are the stem cells of developing prostate, bladder, and colorectal epithelia [Developmental Biology]
14-05-2013 | Jean-Christophe Pignon; Chiara Grisanzio; Yan Geng; Jiaxi Song; Ramesh A. Shivdasani; Sabina Signoretti, Proceedings of the National Academy of Sciences current issue, 2013
The tumor protein p63 (p63), and more specifically the NH2-terminal truncated (ΔN) p63 isoform, is a marker of basal epithelial cells and is required for normal development of several epithelial tissues, including the bladder and prostate glands. Although p63-expressing cells are proposed to ...
Arabidopsis nanodomain-delimited ABA signaling pathway regulates the anion channel SLAH3 [Plant Biology]
14-05-2013 | Fatih Demir; Claudia Horntrich; Jörg O. Blachutzik; Sönke Scherzer; Yvonne Reinders; Sylwia Kierszniowska; Waltraud ..., Proceedings of the National Academy of Sciences current issue, 2013
The phytohormone abscisic acid (ABA) plays a key role in the plant response to drought stress. Hence, ABA-dependent gene transcription and ion transport is regulated by a variety of protein kinases and phosphatases. However, the nature of the membrane-delimited ABA signal transduction steps ...
Smoke-derived karrikin perception by the {alpha}/{beta}-hydrolase KAI2 from Arabidopsis [Plant Biology]
14-05-2013 | Yongxia Guo; Zuyu Zheng; James J. La Clair; Joanne Chory; Joseph P. Noel, Proceedings of the National Academy of Sciences current issue, 2013
Genetic studies in Arabidopsis implicate an α/β-hydrolase, KARRIKIN-INSENSITIVE 2 (KAI2) as a receptor for karrikins, germination-promoting butenolide small molecules found in the smoke of burned plants. However, direct biochemical evidence for the interaction between KAI2 and karrikin and ...
Stepwise protein folding at near amino acid resolution by hydrogen exchange and mass spectrometry [Biophysics and Computational Biology]
07-05-2013 | Wenbing Hu; Benjamin T. Walters; Zhong-Yuan Kan; Leland Mayne; Laura E. Rosen; Susan Marqusee; S. Walter Englander, Proceedings of the National Academy of Sciences current issue, 2013
The kinetic folding of ribonuclease H was studied by hydrogen exchange (HX) pulse labeling with analysis by an advanced fragment separation mass spectrometry technology. The results show that folding proceeds through distinct intermediates in a stepwise pathway that sequentially incorporates ...
Soluble IL7R{alpha} potentiates IL-7 bioactivity and promotes autoimmunity [Immunology]
07-05-2013 | Wangko Lundström; Steven Highfill; Scott T. R. Walsh; Stephanie Beq; Elizabeth Morse; Ingrid Kockum; Lars Alfredsson ..., Proceedings of the National Academy of Sciences current issue, 2013
Human soluble interleukin-7 receptor (sIL7R)α circulates in high molar excess compared with IL-7, but its biology remains unclear. We demonstrate that sIL7Rα has moderate affinity for IL-7 but does not bind thymic stromal lymphopoietin. Functionally, sIL7Rα competes with cell-associated IL-7 ...
A 4-gigabase physical map unlocks the structure and evolution of the complex genome of Aegilops tauschii, the wheat D-genome progenitor [Plant Biology]
07-05-2013 | Ming-Cheng Luo; Yong Q. Gu; Frank M. You; Karin R. Deal; Yaqin Ma; Yuqin Hu; Naxin Huo; Yi Wang; Jirui Wang; Shiyong ..., Proceedings of the National Academy of Sciences current issue, 2013
The current limitations in genome sequencing technology require the construction of physical maps for high-quality draft sequences of large plant genomes, such as that of Aegilops tauschii, the wheat D-genome progenitor. To construct a physical map of the Ae. tauschii genome, we fingerprinted ...
Bringing the ocean into the laboratory to probe the chemical complexity of sea spray aerosol [Chemistry]
07-05-2013 | Kimberly A. Prather; Timothy H. Bertram; Vicki H. Grassian; Grant B. Deane; M. Dale Stokes; Paul J. DeMott; Lihini I ..., Proceedings of the National Academy of Sciences current issue, 2013
The production, size, and chemical composition of sea spray aerosol (SSA) particles strongly depend on seawater chemistry, which is controlled by physical, chemical, and biological processes. Despite decades of studies in marine environments, a direct relationship has yet to be established ...
In This Issue [This Week in PNAS]
07-05-2013 | Proceedings of the National Academy of Sciences current issue, 2013
Ocean-atmosphere facility replicates sea spray aerosolsSea spray aerosol particles vary greatly in size and chemical composition. Decades of study have revealed many of the complex physical, chemical, and biological processes that determine seawater chemistry, yet researchers have been unable ...
Hippo-Foxa2 signaling pathway plays a role in peripheral lung maturation and surfactant homeostasis [Developmental Biology]
07-05-2013 | Chaeuk Chung; Tackhoon Kim; Miju Kim; Minchul Kim; Hoogeun Song; Tae-Shin Kim; Eunjeong Seo; Sang-Hee Lee; Hanbyul K ..., Proceedings of the National Academy of Sciences current issue, 2013
Respiratory distress syndrome (RDS), which is induced by insufficient production of surfactant, is the leading cause of mortality in preterm babies. Although several transcription factors are known to be involved in surfactant protein expression, the molecular mechanisms and signaling ...
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