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1,352 Newest Publications in proceedings of the national academy of sciences current issue

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Visualization and quantification of nascent RAD51 filament formation at single-monomer resolution [Biophysics and Computational Biology]

21-10-2014 | Andrea Candelli; Jan Thomas Holthausen; Martin Depken; Ineke Brouwer; Mariëlla A. M. Franker; Margherita Marchetti; ..., Proceedings of the National Academy of Sciences current issue, 2014

During recombinational repair of double-stranded DNA breaks, RAD51 recombinase assembles as a nucleoprotein filament around single-stranded DNA to form a catalytically proficient structure able to promote homology recognition and strand exchange. Mediators and accessory factors guide the action ...

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Single-molecule packaging initiation in real time by a viral DNA packaging machine from bacteriophage T4 [Biophysics and Computational Biology]

21-10-2014 | Reza Vafabakhsh; Kiran Kondabagil; Tyler Earnest; Kyung Suk Lee; Zhihong Zhang; Li Dai; Karin A. Dahmen; Venigalla B ..., Proceedings of the National Academy of Sciences current issue, 2014

Viral DNA packaging motors are among the most powerful molecular motors known. A variety of structural, biochemical, and single-molecule biophysical approaches have been used to understand their mechanochemistry. However, packaging initiation has been difficult to analyze because of its transient ...

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Computational design of a self-assembling symmetrical {beta}-propeller protein [Biophysics and Computational Biology]

21-10-2014 | Arnout R. D. Voet; Hiroki Noguchi; Christine Addy; David Simoncini; Daiki Terada; Satoru Unzai; Sam-Yong Park; Kam Y ..., Proceedings of the National Academy of Sciences current issue, 2014

The modular structure of many protein families, such as β-propeller proteins, strongly implies that duplication played an important role in their evolution, leading to highly symmetrical intermediate forms. Previous attempts to create perfectly symmetrical propeller proteins have failed, however. ...

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A receptor-like protein mediates the response to pectin modification by activating brassinosteroid signaling [Plant Biology]

21-10-2014 | Sebastian Wolf; Dieuwertje van der Does; Friederike Ladwig; Carsten Sticht; Andreas Kolbeck; Ann-Kathrin Schürholz; ..., Proceedings of the National Academy of Sciences current issue, 2014

The brassinosteroid (BR) signaling module is a central regulator of plant morphogenesis, as indicated by the large number of BR-responsive cell wall-related genes and the severe growth defects of BR mutants. Despite a detailed knowledge of the signaling components, the logic of this ...

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Conformational coupling between the active site and residues within the KC-channel of the Vibrio cholerae cbb3-type (C-family) oxygen reductase [Biophysics and Computational Biology]

21-10-2014 | Young O. Ahn; Paween Mahinthichaichan; Hyun Ju Lee; Hanlin Ouyang; Daniel Kaluka; Syun-Ru Yeh; Davinia Arjona; Denis ..., Proceedings of the National Academy of Sciences current issue, 2014

The respiratory chains of nearly all aerobic organisms are terminated by proton-pumping heme-copper oxygen reductases (HCOs). Previous studies have established that C-family HCOs contain a single channel for uptake from the bacterial cytoplasm of all chemical and pumped protons, and that the ...

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Nitrate foraging by Arabidopsis roots is mediated by the transcription factor TCP20 through the systemic signaling pathway [Plant Biology]

21-10-2014 | Peizhu Guan; Rongchen Wang; Philippe Nacry; Ghislain Breton; Steve A. Kay; Jose L. Pruneda-Paz; Ariea Davani; Nigel ..., Proceedings of the National Academy of Sciences current issue, 2014

To compete for nutrients in diverse soil microenvironments, plants proliferate lateral roots preferentially in nutrient-rich zones. For nitrate, root foraging involves local and systemic signaling; however, little is known about the genes that function in the systemic signaling pathway. By using ...

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Structure of a PE-PPE-EspG complex from Mycobacterium tuberculosis reveals molecular specificity of ESX protein secretion [Biophysics and Computational Biology]

14-10-2014 | Damian C. Ekiert; Jeffery S. Cox, Proceedings of the National Academy of Sciences current issue, 2014

Nearly 10% of the coding capacity of the Mycobacterium tuberculosis genome is devoted to two highly expanded and enigmatic protein families called PE and PPE, some of which are important virulence/immunogenicity factors and are secreted during infection via a unique alternative secretory system ...

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Evidence for close side-chain packing in an early protein folding intermediate previously assumed to be a molten globule [Biophysics and Computational Biology]

14-10-2014 | Laura E. Rosen; Katelyn B. Connell; Susan Marqusee, Proceedings of the National Academy of Sciences current issue, 2014

The molten globule, a conformational ensemble with significant secondary structure but only loosely packed tertiary structure, has been suggested to be a ubiquitous intermediate in protein folding. However, it is difficult to assess the tertiary packing of transiently populated species to ...

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Structure of nicastrin unveils secrets of {gamma}-secretase [Biophysics and Computational Biology]

14-10-2014 | David M. Bolduc; Michael S. Wolfe, Proceedings of the National Academy of Sciences current issue, 2014

Despite afflicting tens of millions worldwide, Alzheimer’s disease (AD) remains a devastating brain-destroying malady with no effective treatment or cure. A central hallmark of AD is the deposition of amyloid plaques in the brain. These plaques are primarily composed of the amyloid β-peptide ...

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Jake MacMillan: A pioneering chemist in plant biology [Retrospectives]

14-10-2014 | Peter Hedden; Michael H. Beale, Proceedings of the National Academy of Sciences current issue, 2014

Jake MacMillan, who died on May 12, 2014 at the age of 89, was an organic chemist who made an enormous contribution to plant science, particularly in relation to the structure, biosynthesis, and analysis of the gibberellin plant hormones. Jake was born in Wishaw, Scotland, into a lower working ...

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