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1,436 Newest Publications in proceedings of the national academy of sciences current issue

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Maternal temperature history activates Flowering Locus T in fruits to control progeny dormancy according to time of year [Plant Biology]

30-Dec-2014 | Min Chen; Dana R. MacGregor; Anuja Dave; Hannah Florance; Karen Moore; Konrad Paszkiewicz; Nicholas Smirnoff; Ian A. ..., Proceedings of the National Academy of Sciences current issue, 2014

Seasonal behavior is important for fitness in temperate environments but it is unclear how progeny gain their initial seasonal entrainment. Plants use temperature signals to measure time of year, and changes to life histories are therefore an important consequence of climate change. Here we show ...

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TDP-43 N terminus encodes a novel ubiquitin-like fold and its unfolded form in equilibrium that can be shifted by binding to ssDNA [Biophysics and Computational Biology]

30-Dec-2014 | Haina Qin; Liang-Zhong Lim; Yuanyuan Wei; Jianxing Song, Proceedings of the National Academy of Sciences current issue, 2014

Transactivation response element (TAR) DNA-binding protein 43 (TDP-43) is the principal component of ubiquitinated inclusions characteristic of most forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia-frontotemporal lobar degeneration with TDP-43–positive inclusions ...

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PTEN signaling through RAF1 proto-oncogene serine/threonine kinase (RAF1)/ERK in the epididymis is essential for male fertility [Developmental Biology]

30-Dec-2014 | Bingfang Xu; Angela M. Washington; Barry T. Hinton, Proceedings of the National Academy of Sciences current issue, 2014

Without a fully developed initial segment, the most proximal region of the epididymis, male infertility results. Therefore, it is important to understand the development and regulation of this crucial region. In addition to distinctively high activity levels of the components of the ERK pathway, ...

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Structural basis of HIV-1 capsid recognition by PF74 and CPSF6 [Biophysics and Computational Biology]

30-Dec-2014 | Akash Bhattacharya; Steven L. Alam; Thomas Fricke; Kaneil Zadrozny; Jaroslaw Sedzicki; Alexander B. Taylor; Borries ..., Proceedings of the National Academy of Sciences current issue, 2014

Upon infection of susceptible cells by HIV-1, the conical capsid formed by ∼250 hexamers and 12 pentamers of the CA protein is delivered to the cytoplasm. The capsid shields the RNA genome and proteins required for reverse transcription. In addition, the surface of the capsid mediates numerous ...

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Bifurcation analysis of single-cell gene expression data reveals epigenetic landscape [Biophysics and Computational Biology]

30-Dec-2014 | Eugenio Marco; Robert L. Karp; Guoji Guo; Paul Robson; Adam H. Hart; Lorenzo Trippa; Guo-Cheng Yuan, Proceedings of the National Academy of Sciences current issue, 2014

We present single-cell clustering using bifurcation analysis (SCUBA), a novel computational method for extracting lineage relationships from single-cell gene expression data and modeling the dynamic changes associated with cell differentiation. SCUBA draws techniques from nonlinear dynamics and ...

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Maize SBP-box transcription factors unbranched2 and unbranched3 affect yield traits by regulating the rate of lateral primordia initiation [Plant Biology]

30-Dec-2014 | George S. Chuck; Patrick J. Brown; Robert Meeley; Sarah Hake, Proceedings of the National Academy of Sciences current issue, 2014

The separation of male and female flowers in maize provides the potential for independent regulation of traits that affect crop productivity. For example, tassel branch number controls pollen abundance and length of shedding time, whereas ear row number directly affects kernel yield. Mutations in ...

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In silico selection of therapeutic antibodies for development: Viscosity, clearance, and chemical stability [Biophysics and Computational Biology]

30-Dec-2014 | Vikas K. Sharma; Thomas W. Patapoff; Bruce Kabakoff; Satyan Pai; Eric Hilario; Boyan Zhang; Charlene Li; Oleg Boriso ..., Proceedings of the National Academy of Sciences current issue, 2014

For mAbs to be viable therapeutics, they must be formulated to have low viscosity, be chemically stable, and have normal in vivo clearance rates. We explored these properties by observing correlations of up to 60 different antibodies of the IgG1 isotype. Unexpectedly, we observe significant ...

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Topological sensitivity analysis for systems biology [Biophysics and Computational Biology]

30-Dec-2014 | Ann C. Babtie; Paul Kirk; Michael P. H. Stumpf, Proceedings of the National Academy of Sciences current issue, 2014

Mathematical models of natural systems are abstractions of much more complicated processes. Developing informative and realistic models of such systems typically involves suitable statistical inference methods, domain expertise, and a modicum of luck. Except for cases where physical principles ...

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Structural basis for the auxin-induced transcriptional regulation by Aux/IAA17 [Biophysics and Computational Biology]

30-Dec-2014 | Mookyoung Han; Yangshin Park; Iktae Kim; Eun-Hee Kim; Tae-Kyung Yu; Sangkee Rhee; Jeong-Yong Suh, Proceedings of the National Academy of Sciences current issue, 2014

Auxin is the central hormone that regulates plant growth and organ development. Transcriptional regulation by auxin is mediated by the auxin response factor (ARF) and the repressor, AUX/IAA. Aux/IAA associates with ARF via domain III−IV for transcriptional repression that is reversed by ...

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Detergent-free isolation, characterization, and functional reconstitution of a tetrameric K+ channel: The power of native nanodiscs [Biophysics and Computational Biology]

30-Dec-2014 | Jonas M. Dörr; Martijn C. Koorengevel; Marre Schäfer; Alexander V. Prokofyev; Stefan Scheidelaar; Elwin A. W. van de ..., Proceedings of the National Academy of Sciences current issue, 2014

A major obstacle in the study of membrane proteins is their solubilization in a stable and active conformation when using detergents. Here, we explored a detergent-free approach to isolating the tetrameric potassium channel KcsA directly from the membrane of Escherichia coli, using a ...

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