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1,592 Newest Publications in proceedings of the national academy of sciences current issue

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Syringyl lignin production in conifers: Proof of concept in a Pine tracheary element system [Plant Biology]

12-May-2015 | Armin Wagner; Yuki Tobimatsu; Lorelle Phillips; Heather Flint; Barbara Geddes; Fachuang Lu; John Ralph, Proceedings of the National Academy of Sciences current issue, 2015

Conifers (softwoods) naturally lack syringyl units in their lignins, rendering lignocellulosic materials from such species more difficult to process than syringyl-rich hardwood species. Using a transformable Pinus radiata tracheary element (TE) system as an experimental platform, we investigated ...

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Neural crest cell-derived VEGF promotes embryonic jaw extension [Developmental Biology]

12-May-2015 | Sophie Wiszniak; Francesca E. Mackenzie; Peter Anderson; Samuela Kabbara; Christiana Ruhrberg; Quenten Schwarz, Proceedings of the National Academy of Sciences current issue, 2015

Jaw morphogenesis depends on the growth of Meckel’s cartilage during embryogenesis. However, the cell types and signals that promote chondrocyte proliferation for Meckel’s cartilage growth are poorly defined. Here we show that neural crest cells (NCCs) and their derivatives provide an essential ...

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How a well-adapted immune system is organized [Biophysics and Computational Biology]

12-May-2015 | Andreas Mayer; Vijay Balasubramanian; Thierry Mora; Aleksandra M. Walczak, Proceedings of the National Academy of Sciences current issue, 2015

The repertoire of lymphocyte receptors in the adaptive immune system protects organisms from diverse pathogens. A well-adapted repertoire should be tuned to the pathogenic environment to reduce the cost of infections. We develop a general framework for predicting the optimal repertoire that ...

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Architecture and migration of an epithelium on a cylindrical wire [Biophysics and Computational Biology]

12-May-2015 | Hannah G. Yevick; Guillaume Duclos; Isabelle Bonnet; Pascal Silberzan, Proceedings of the National Academy of Sciences current issue, 2015

In a wide range of epithelial tissues such as kidney tubules or breast acini, cells organize into bidimensional monolayers experiencing an out-of-plane curvature. Cancer cells can also migrate collectively from epithelial tumors by wrapping around vessels or muscle fibers. However, in vitro ...

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iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling [Developmental Biology]

12-May-2015 | Xue Li; Thorsten Maretzky; Gisela Weskamp; Sébastien Monette; Xiaoping Qing; Priya Darshinee A. Issuree; Howard C. C ..., Proceedings of the National Academy of Sciences current issue, 2015

The metalloproteinase ADAM17 (a disintegrin and metalloprotease 17) controls EGF receptor (EGFR) signaling by liberating EGFR ligands from their membrane anchor. Consequently, a patient lacking ADAM17 has skin and intestinal barrier defects that are likely caused by lack of EGFR signaling, and ...

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Structure-relaxation mechanism for the response of T4 lysozyme cavity mutants to hydrostatic pressure [Biophysics and Computational Biology]

12-May-2015 | Michael T. Lerch; Carlos J. López; Zhongyu Yang; Margaux J. Kreitman; Joseph Horwitz; Wayne L. Hubbell, Proceedings of the National Academy of Sciences current issue, 2015

Application of hydrostatic pressure shifts protein conformational equilibria in a direction to reduce the volume of the system. A current view is that the volume reduction is dominated by elimination of voids or cavities in the protein interior via cavity hydration, although an alternative ...

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Plastid-produced interorgannellar stress signal MEcPP potentiates induction of the unfolded protein response in endoplasmic reticulum [Plant Biology]

12-May-2015 | Justin Walley; Yanmei Xiao; Jin-Zheng Wang; Edward E. Baidoo; Jay D. Keasling; Zhouxin Shen; Steven P. Briggs; Katay ..., Proceedings of the National Academy of Sciences current issue, 2015

Cellular homeostasis in response to internal and external stimuli requires a tightly coordinated interorgannellar communication network. We recently identified methylerythritol cyclodiphosphate (MEcPP) as a novel stress-specific retrograde signaling metabolite that accumulates in response to ...

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Correction for Brodersen et al., Isoprenoid biosynthesis is required for miRNA function and affects membrane association of ARGONAUTE 1 in Arabidopsis [Correction]

12-May-2015 | Proceedings of the National Academy of Sciences current issue, 2015

PLANT BIOLOGY Correction for “Isoprenoid biosynthesis is required for miRNA function and affects membrane association of ARGONAUTE 1 in Arabidopsis,” by Peter Brodersen, Lali Sakvarelidze-Achard, Hubert Schaller, Mehdi Khafif, Grégory Schott, Abdelhafid Bendahmane, and Olivier Voinnet, which ...

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Multiple stiffening effects of nanoscale knobs on human red blood cells infected with Plasmodium falciparum malaria parasite [Biophysics and Computational Biology]

12-May-2015 | Yao Zhang; Changjin Huang; Sangtae Kim; Mahdi Golkaram; Matthew W. A. Dixon; Leann Tilley; Ju Li; Sulin Zhang; Subra ..., Proceedings of the National Academy of Sciences current issue, 2015

During its asexual development within the red blood cell (RBC), Plasmodium falciparum (Pf), the most virulent human malaria parasite, exports proteins that modify the host RBC membrane. The attendant increase in cell stiffness and cytoadherence leads to sequestration of infected RBCs in ...

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Correction for Liu et al., Solid-to-fluid-like DNA transition in viruses facilitates infection [Correction]

05-May-2015 | Proceedings of the National Academy of Sciences current issue, 2015

CHEMISTRY, BIOPHYSICS AND COMPUTATIONAL BIOLOGY Correction for “Solid-to-fluid–like DNA transition in viruses facilitates infection,” by Ting Liu, Udom Sae-Ueng, Dong Li, Gabriel C. Lander, Xiaobing Zuo, Bengt Jönsson, Donald Rau, Ivetta Shefer, and Alex Evilevitch, which appeared in issue 41, ...

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