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519 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

Ligand-directed targeting of lymphatic vessels uncovers mechanistic insights in melanoma metastasis [Medical Sciences]

24-Feb-2015 | Dawn R. Christianson; Andrey S. Dobroff; Bettina Proneth; Amado J. Zurita; Ahmad Salameh; Eleonora Dondossola; Jun M ..., Proceedings of the National Academy of Sciences current issue, 2015

Metastasis is the most lethal step of cancer progression in patients with invasive melanoma. In most human cancers, including melanoma, tumor dissemination through the lymphatic vasculature provides a major route for tumor metastasis. Unfortunately, molecular mechanisms that facilitate ...

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Silencing LRH-1 in colon cancer cell lines impairs proliferation and alters gene expression programs [Cell Biology]

24-Feb-2015 | James R. Bayrer; Sridevi Mukkamala; Elena P. Sablin; Paul Webb; Robert J. Fletterick, Proceedings of the National Academy of Sciences current issue, 2015

Colorectal cancers (CRCs) account for nearly 10% of all cancer deaths in industrialized countries. Recent evidence points to a central role for the nuclear receptor liver receptor homolog-1 (LRH-1) in intestinal tumorigenesis. Interaction of LRH-1 with the Wnt/β-catenin pathway, highly active in ...

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Extensive tissue-related and allele-related mtDNA heteroplasmy suggests positive selection for somatic mutations [Genetics]

24-Feb-2015 | Mingkun Li; Roland Schröder; Shengyu Ni; Burkhard Madea; Mark Stoneking, Proceedings of the National Academy of Sciences current issue, 2015

Heteroplasmy in human mtDNA may play a role in cancer, other diseases, and aging, but patterns of heteroplasmy variation across different tissues have not been thoroughly investigated. Here, we analyzed complete mtDNA genome sequences at ∼3,500× average coverage from each of 12 tissues obtained ...

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Glycosylation profiles determine extravasation and disease-targeting properties of armed antibodies [Applied Biological Sciences]

17-Feb-2015 | Dario Venetz; Christian Hess; Chia-wei Lin; Markus Aebi; Dario Neri, Proceedings of the National Academy of Sciences current issue, 2015

The ability of antibodies to extravasate out of blood vessels is critical for therapeutic activity, because molecular targets for most diseases are located outside of the endothelial lining. By performing detailed biodistribution studies with a novel IL9-armed cancer-specific antibody, we ...

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NADPH oxidase 4 is a critical mediator in Ataxia telangiectasia disease [Genetics]

17-Feb-2015 | Urbain Weyemi; Christophe E. Redon; Towqir Aziz; Rohini Choudhuri; Daisuke Maeda; Palak R. Parekh; Michael Y. Bonner ..., Proceedings of the National Academy of Sciences current issue, 2015

Ataxia telangiectasia (A-T), a rare autosomal recessive disorder characterized by progressive cerebellar degeneration and a greatly increased incidence of cancer among other symptoms, is caused by a defective or missing ataxia telangiectasia mutated (ATM) gene. The ATM protein has roles in DNA ...

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Heterogeneity for IGF-II production maintained by public goods dynamics in neuroendocrine pancreatic cancer [Medical Sciences]

10-Feb-2015 | Marco Archetti; Daniela A. Ferraro; Gerhard Christofori, Proceedings of the National Academy of Sciences current issue, 2015

The extensive intratumor heterogeneity revealed by sequencing cancer genomes is an essential determinant of tumor progression, diagnosis, and treatment. What maintains heterogeneity remains an open question because competition within a tumor leads to a strong selection for the fittest subclone. ...

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Immune-mediated antitumor effect by type 2 diabetes drug, metformin [Immunology and Inflammation]

10-Feb-2015 | Shingo Eikawa; Mikako Nishida; Shusaku Mizukami; Chihiro Yamazaki; Eiichi Nakayama; Heiichiro Udono, Proceedings of the National Academy of Sciences current issue, 2015

Metformin, a prescribed drug for type 2 diabetes, has been reported to have anti-cancer effects; however, the underlying mechanism is poorly understood. Here we show that this mechanism may be immune-mediated. Metformin enabled normal but not T-cell–deficient SCID mice to reject solid tumors. In ...

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Suppression of cancer relapse and metastasis by inhibiting cancer stemness [Medical Sciences]

10-Feb-2015 | Youzhi Li; Harry A. Rogoff; Sarah Keates; Yuan Gao; Sylaja Murikipudi; Keith Mikule; David Leggett; Wei Li; Arthur B ..., Proceedings of the National Academy of Sciences current issue, 2015

Partial or even complete cancer regression can be achieved in some patients with current cancer treatments. However, such initial responses are almost always followed by relapse, with the recurrent cancer being resistant to further treatments. The discovery of therapeutic approaches that ...

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Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils [Medical Sciences]

10-Feb-2015 | Amy-Jo Casbon; Damien Reynaud; Chanhyuk Park; Emily Khuc; Dennis D. Gan; Koen Schepers; Emmanuelle Passegué; Zena Werb, Proceedings of the National Academy of Sciences current issue, 2015

Expansion of myeloid cells associated with solid tumor development is a key contributor to neoplastic progression. Despite their clinical relevance, the mechanisms controlling myeloid cell production and activity in cancer remains poorly understood. Using a multistage mouse model of breast ...

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Microtubule-targeting agents augment the toxicity of DNA-damaging agents by disrupting intracellular trafficking of DNA repair proteins [Medical Sciences]

03-Feb-2015 | Marianne S. Poruchynsky; Edina Komlodi-Pasztor; Shana Trostel; Julia Wilkerson; Marie Regairaz; Yves Pommier; Xu Zha ..., Proceedings of the National Academy of Sciences current issue, 2015

The paradigm that microtubule-targeting agents (MTAs) cause cell death via mitotic arrest applies to rapidly dividing cells but cannot explain MTA activity in slowly growing human cancers. Many preferred cancer regimens combine a MTA with a DNA-damaging agent (DDA). We hypothesized that MTAs ...

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