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484 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

Fibroblasts probe substrate rigidity with filopodia extensions before occupying an area [Biophysics and Computational Biology]

02-12-2014 | Stephanie Wong; Wei-Hui Guo; Yu-Li Wang, Proceedings of the National Academy of Sciences current issue, 2014

Rigidity sensing and durotaxis are thought to be important elements in wound healing, tissue formation, and cancer treatment. It has been challenging, however, to study the underlying mechanism due to difficulties in capturing cells during the transient response to a rigidity interface. We have ...

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Topoisomerase 1 inhibition reversibly impairs synaptic function [Neuroscience]

02-12-2014 | Angela M. Mabb; Paul H. M. Kullmann; Margaret A. Twomey; Jayalakshmi Miriyala; Benjamin D. Philpot; Mark J. Zylka, Proceedings of the National Academy of Sciences current issue, 2014

Topotecan is a topoisomerase 1 (TOP1) inhibitor that is used to treat various forms of cancer. We recently found that topotecan reduces the expression of multiple long genes, including many neuronal genes linked to synapses and autism. However, whether topotecan alters synaptic protein levels and ...

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NanoFlares for the detection, isolation, and culture of live tumor cells from human blood [Applied Biological Sciences]

02-12-2014 | Tiffany L. Halo; Kaylin M. McMahon; Nicholas L. Angeloni; Yilin Xu; Wei Wang; Alyssa B. Chinen; Dmitry Malin; Elena ..., Proceedings of the National Academy of Sciences current issue, 2014

Metastasis portends a poor prognosis for cancer patients. Primary tumor cells disseminate through the bloodstream before the appearance of detectable metastatic lesions. The analysis of cancer cells in blood—so-called circulating tumor cells (CTCs)—may provide unprecedented opportunities for ...

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Ovarian cancer stem cells express ROR1, which can be targeted for anti-cancer-stem-cell therapy [Medical Sciences]

02-12-2014 | Suping Zhang; Bing Cui; Hsien Lai; Grace Liu; Emanuela M. Ghia; George F. Widhopf II; Zhuhong Zhang; Christina C. N. ..., Proceedings of the National Academy of Sciences current issue, 2014

Although initially responsive to chemotherapy, many patients with ovarian cancer subsequently develop relapsed and potentially fatal metastatic disease, which is thought to develop from cancer stem cells (CSCs) that are relatively resistant to conventional therapy. Here, we show that CSCs express ...

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Intravital imaging reveals distinct responses of depleting dynamic tumor-associated macrophage and dendritic cell subpopulations [Medical Sciences]

25-11-2014 | Marja Lohela; Amy-Jo Casbon; Aleksandra Olow; Lynn Bonham; Daniel Branstetter; Ning Weng; Jeffrey Smith; Zena Werb, Proceedings of the National Academy of Sciences current issue, 2014

Tumor-infiltrating inflammatory cells comprise a major part of the stromal microenvironment and support cancer progression by multiple mechanisms. High numbers of tumor myeloid cells correlate with poor prognosis in breast cancer and are coupled with the angiogenic switch and malignant ...

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Sample processing obscures cancer-specific alterations in leukemic transcriptomes [Genetics]

25-11-2014 | Heidi Dvinge; Rhonda E. Ries; Janine O. Ilagan; Derek L. Stirewalt; Soheil Meshinchi; Robert K. Bradley, Proceedings of the National Academy of Sciences current issue, 2014

Substantial effort is currently devoted to identifying cancer-associated alterations using genomics. Here, we show that standard blood collection procedures rapidly change the transcriptional and posttranscriptional landscapes of hematopoietic cells, resulting in biased activation of specific ...

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Bap1 is essential for kidney function and cooperates with Vhl in renal tumorigenesis [Medical Sciences]

18-11-2014 | Shan-Shan Wang; Yi-Feng Gu; Nicholas Wolff; Karoliina Stefanius; Alana Christie; Anwesha Dey; Robert E. Hammer; Xian ..., Proceedings of the National Academy of Sciences current issue, 2014

Why different species are predisposed to different tumor spectra is not well understood. In particular, whether the physical location of tumor suppressor genes relative to one another influences tumor predisposition is unknown. Renal cancer presents a unique opportunity to explore this question. ...

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RUNX1 is essential for mesenchymal stem cell proliferation and myofibroblast differentiation [Cell Biology]

18-11-2014 | Woosook Kim; David A. Barron; Rebeca San Martin; Keith S. Chan; Linda L. Tran; Feng Yang; Steven J. Ressler; David R ..., Proceedings of the National Academy of Sciences current issue, 2014

Myofibroblasts are a key cell type in wound repair, cardiovascular disease, and fibrosis and in the tumor-promoting microenvironment. The high accumulation of myofibroblasts in reactive stroma is predictive of the rate of cancer progression in many different tumors, yet the cell types of origin ...

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The Runt-related transcription factor 1 in prostate cancer-associated fibroblasts [Cell Biology]

18-11-2014 | Hilary A. Coller, Proceedings of the National Academy of Sciences current issue, 2014

Although most carcinomas arise from a series of genetic alterations in epithelial cells, cancer is a disease that affects not just the transformed cells themselves, but the entire tissue. During tumor development, reciprocal signaling patterns between the cancer cells and the surrounding tissue ...

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Sex disparity in colonic adenomagenesis involves promotion by male hormones, not protection by female hormones [Medical Sciences]

18-11-2014 | James M. Amos-Landgraf; Jarom Heijmans; Mattheus C. B. Wielenga; Elisa Dunkin; Kathy J. Krentz; Linda Clipson; Antwa ..., Proceedings of the National Academy of Sciences current issue, 2014

It recently has been recognized that men develop colonic adenomas and carcinomas at an earlier age and at a higher rate than women. In the ApcPirc/+ (Pirc) rat model of early colonic cancer, this sex susceptibility was recapitulated, with male Pirc rats developing twice as many adenomas as ...

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