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400 Newest Publications in proceedings of the national academy of sciences current issue
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matching the following criteria
Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer [Immunology]
11-06-2013 | Bo Hu; Eran Elinav; Samuel Huber; Till Strowig; Liming Hao; Anja Hafemann; Chengcheng Jin; Stephanie C. Eisenbarth; ..., Proceedings of the National Academy of Sciences current issue, 2013
The microbiota is pivotal in the pathogenesis of inflammatory bowel disease (IBD)-associated inflammation-induced colorectal cancer (CRC), yet mechanisms for these effects remain poorly characterized. Here, we demonstrate that aberrant inflammasome-induced microbiota plays a critical role in ...
Mass spectrometry reveals synergistic effects of nucleotides, lipids, and drugs binding to a multidrug resistance efflux pump [Chemistry]
11-06-2013 | Julien Marcoux; Sheila C. Wang; Argyris Politis; Eamonn Reading; Jerome Ma; Philip C. Biggin; Min Zhou; Houchao Tao; ..., Proceedings of the National Academy of Sciences current issue, 2013
Multidrug resistance is a serious barrier to successful treatment of many human diseases, including cancer, wherein chemotherapeutics are exported from target cells by membrane-embedded pumps. The most prevalent of these pumps, the ATP-Binding Cassette transporter P-glycoprotein (P-gp), ...
Genetic screens to identify pathogenic gene variants in the common cancer predisposition Lynch syndrome [Genetics]
04-06-2013 | Mark Drost; Anne Lützen; Sandrine van Hees; Daniel Ferreira; Fabienne Calléja; José B. M. Zonneveld; Finn Cilius Nie ..., Proceedings of the National Academy of Sciences current issue, 2013
In many individuals suspected of the common cancer predisposition Lynch syndrome, variants of unclear significance (VUS), rather than an obviously pathogenic mutations, are identified in one of the DNA mismatch repair (MMR) genes. The uncertainty of whether such VUS inactivate MMR, and ...
Ninjurin1, a target of p53, regulates p53 expression and p53-dependent cell survival, senescence, and radiation-induced mortality [Cell Biology]
04-06-2013 | Seong-Jun Cho; Andrea Rossi; Yong-Sam Jung; Wensheng Yan; Gang Liu; Jin Zhang; Min Zhang; Xinbin Chen, Proceedings of the National Academy of Sciences current issue, 2013
The tumor suppressor protein p53 plays a crucial role in coordinating cellular processes, such as cell cycle arrest, apoptosis, and senescence. The nerve injury-induced protein 1 (Ninjurin1, Ninj1) is a homophilic adhesion molecule and involved in nerve regeneration. Interestingly, Ninj1 is ...
Link between obesity and cancer [News Feature]
28-05-2013 | Sarah C. P. Williams, Proceedings of the National Academy of Sciences current issue, 2013
Around one-fifth of cancer deaths in the United States are associated with obesity. But how is fat fueling the growth of tumors? Most of the mice in Stephen Hursting’s laboratory at the University of Texas in Austin have cancer. However, among mice with identical genetics and the same tumor ...
End-binding proteins sensitize microtubules to the action of microtubule-targeting agents [Biochemistry]
28-05-2013 | Renu Mohan; Eugene A. Katrukha; Harinath Doodhi; Ihor Smal; Erik Meijering; Lukas C. Kapitein; Michel O. Steinmetz; ..., Proceedings of the National Academy of Sciences current issue, 2013
Microtubule-targeting agents (MTAs) are widely used for treatment of cancer and other diseases, and a detailed understanding of the mechanism of their action is important for the development of improved microtubule-directed therapies. Although there is a large body of data on the interactions ...
Dynamic dual-tracer MRI-guided fluorescence tomography to quantify receptor density in vivo [Engineering]
28-05-2013 | Scott C. Davis; Kimberley S. Samkoe; Kenneth M. Tichauer; Kristian J. Sexton; Jason R. Gunn; Sophie J. Deharvengt; T ..., Proceedings of the National Academy of Sciences current issue, 2013
The up-regulation of cell surface receptors has become a central focus in personalized cancer treatment; however, because of the complex nature of contrast agent pharmacokinetics in tumor tissue, methods to quantify receptor binding in vivo remain elusive. Here, we present a dual-tracer ...
Visualizing cellular interactions with a generalized proximity reporter [Cell Biology]
21-05-2013 | Mark A. Sellmyer; Laura Bronsart; Hiroshi Imoto; Christopher H. Contag; Thomas J. Wandless; Jennifer A. Prescher, Proceedings of the National Academy of Sciences current issue, 2013
Interactions among neighboring cells underpin many physiological processes ranging from early development to immune responses. When these interactions do not function properly, numerous pathologies, including infection and cancer, can result. Molecular imaging technologies, especially optical ...
Single-agent combinatorial cancer therapy [Medical Sciences]
21-05-2013 | Jochen Stritzker; Aladar A. Szalay, Proceedings of the National Academy of Sciences current issue, 2013
Laboratories all over the world conduct research aimed at developing novel strategies to treat cancer. The approaches include innovative chemotherapy and prodrug agents, therapeutic antibodies, immunotherapies, nanoparticle-based approaches, targeted ultrasound, photodynamic therapy, ...
Self-assembled, aptamer-tethered DNA nanotrains for targeted transport of molecular drugs in cancer theranostics [Applied Biological Sciences]
14-05-2013 | Guizhi Zhu; Jing Zheng; Erqun Song; Michael Donovan; Kejing Zhang; Chen Liu; Weihong Tan, Proceedings of the National Academy of Sciences current issue, 2013
Nanotechnology has allowed the construction of various nanostructures for applications, including biomedicine. However, a simple target-specific, economical, and biocompatible drug delivery platform with high maximum tolerated doses is still in demand. Here, we report aptamer-tethered DNA ...
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