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432 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

Mouse model implicates GNB3 duplication in a childhood obesity syndrome [Genetics]

10-09-2013 | Ian S. Goldlust; Karen E. Hermetz; Lisa M. Catalano; Richard T. Barfield; Rebecca Cozad; Grace Wynn; Alev Cagla Ozde ..., Proceedings of the National Academy of Sciences current issue, 2013

Obesity is a highly heritable condition and a risk factor for other diseases, including type 2 diabetes, cardiovascular disease, hypertension, and cancer. Recently, genomic copy number variation (CNV) has been implicated in cases of early onset obesity that may be comorbid with intellectual ...

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Ether lipid generating enzyme AGPS alters the balance of structural and signaling lipids to fuel cancer pathogenicity [Biochemistry]

10-09-2013 | Daniel I. Benjamin; Alyssa Cozzo; Xiaodan Ji; Lindsay S. Roberts; Sharon M. Louie; Melinda M. Mulvihill; Kunxin Luo; ..., Proceedings of the National Academy of Sciences current issue, 2013

Aberrant lipid metabolism is an established hallmark of cancer cells. In particular, ether lipid levels have been shown to be elevated in tumors, but their specific function in cancer remains elusive. We show here that the metabolic enzyme alkylglyceronephosphate synthase (AGPS), a critical step ...

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Insulin growth factor signaling is regulated by microRNA-486, an underexpressed microRNA in lung cancer [Medical Sciences]

10-09-2013 | Yong Peng; Yuntao Dai; Charles Hitchcock; Xiaojuan Yang; Edmund S. Kassis; Lunxu Liu; Zhenghua Luo; Hui-Lung Sun; Ri ..., Proceedings of the National Academy of Sciences current issue, 2013

MicroRNAs (miRNAs) are small 19- to 24-nt noncoding RNAs that have the capacity to regulate fundamental biological processes essential for cancer initiation and progression. In cancer, miRNAs may function as oncogenes or tumor suppressors. Here, we conducted global profiling for miRNAs in a ...

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Understanding the temporal sequence of genetic events that lead to prostate cancer progression and metastasis [Medical Sciences]

10-09-2013 | Stacey J. Baker; E. Premkumar Reddy, Proceedings of the National Academy of Sciences current issue, 2013

Prostate cancer is the second most common cancer among men, with an estimated 903,000 newly diagnosed cases and 258,000 deaths per year worldwide (1). Although the prognosis is favorable in patients with localized disease, the 5-y survival rate drops to less than 30% for individuals with ...

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Inherited mutations in the helicase RTEL1 cause telomere dysfunction and Hoyeraal-Hreidarsson syndrome [Genetics]

03-09-2013 | Zhong Deng; Galina Glousker; Aliah Molczan; Alan J. Fox; Noa Lamm; Jayaraju Dheekollu; Orr-El Weizman; Michael Scher ..., Proceedings of the National Academy of Sciences current issue, 2013

Telomeres repress the DNA damage response at the natural chromosome ends to prevent cell-cycle arrest and maintain genome stability. Telomeres are elongated by telomerase in a tightly regulated manner to ensure a sufficient number of cell divisions throughout life, yet prevent unlimited cell ...

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Changing the fate of cancer, one splice at a time [Cell Biology]

03-09-2013 | David L. Schonberg; Monica Venere; Jeremy N. Rich, Proceedings of the National Academy of Sciences current issue, 2013

Cells proliferate or differentiate. Conventional wisdom holds that these two dominant forces regulating cell state display a yin-yang relationship, but like all reductionist conclusions, the absolute dichotomization of cell behaviors must be considered with caution, especially in the context of ...

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Neutralization of terminal differentiation in gliomagenesis [Cell Biology]

03-09-2013 | Jian Hu; Allen L. Ho; Liang Yuan; Baoli Hu; Sujun Hua; Soyoon Sarah Hwang; Jianhua Zhang; Tianyi Hu; Hongwu Zheng; B ..., Proceedings of the National Academy of Sciences current issue, 2013

An immature state of cellular differentiation—characterized by stem cell–like tendencies and impaired differentiation—is a hallmark of cancer. Using glioblastoma multiforme (GBM) as a model system, we sought to determine whether molecular determinants that drive cells toward terminal ...

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NAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining mitochondrial homeostasis and promoting tumor growth [Cell Biology]

03-09-2013 | Yang-Sung Sohn; Sagi Tamir; Luhua Song; Dorit Michaeli; Imad Matouk; Andrea R. Conlan; Yael Harir; Sarah H. Holt; Vl ..., Proceedings of the National Academy of Sciences current issue, 2013

Mitochondria are emerging as important players in the transformation process of cells, maintaining the biosynthetic and energetic capacities of cancer cells and serving as one of the primary sites of apoptosis and autophagy regulation. Although several avenues of cancer therapy have focused on ...

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QnAs with Ronald DePinho [QnAs]

03-09-2013 | Prashant Nair, Proceedings of the National Academy of Sciences current issue, 2013

Ronald DePinho has spent most of his waking hours trying to unlock the genetic secrets of aging and cancer. Over the years, DePinho, president of the University of Texas M.D. Anderson Cancer Center in Houston, TX, and a recently elected member of the National Academy of Sciences, has come to...

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Germ-line variant of human NTH1 DNA glycosylase induces genomic instability and cellular transformation [Genetics]

27-08-2013 | Heather A. Galick; Scott Kathe; Minmin Liu; Susan Robey-Bond; Dawit Kidane; Susan S. Wallace; Joann B. Sweasy, Proceedings of the National Academy of Sciences current issue, 2013

Base excision repair (BER) removes at least 20,000 DNA lesions per human cell per day and is critical for the maintenance of genomic stability. We hypothesize that aberrant BER, resulting from mutations in BER genes, can lead to genomic instability and cancer. The first step in BER is catalyzed ...

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