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527 Newest Publications in proceedings of the national academy of sciences current issue

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Regulation of Nrf2 signaling and longevity in naturally long-lived rodents [Cell Biology]

24-Mar-2015 | Kaitlyn N. Lewis; Emily Wason; Yael H. Edrey; Deborah M. Kristan; Eviatar Nevo; Rochelle Buffenstein, Proceedings of the National Academy of Sciences current issue, 2015

The preternaturally long-lived naked mole-rat, like other long-lived species and experimental models of extended longevity, is resistant to both endogenous (e.g., reactive oxygen species) and environmental stressors and also resists age-related diseases such as cancer, cardiovascular disease, and ...

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Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer [Medical Sciences]

17-Mar-2015 | Anthony C. Faber; Anna F. Farago; Carlotta Costa; Anahita Dastur; Maria Gomez-Caraballo; Rebecca Robbins; Bethany L. ..., Proceedings of the National Academy of Sciences current issue, 2015

BH3 mimetics such as ABT-263 induce apoptosis in a subset of cancer models. However, these drugs have shown limited clinical efficacy as single agents in small-cell lung cancer (SCLC) and other solid tumor malignancies, and rational combination strategies remain underexplored. To develop a novel ...

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Implantable hydrogel embedded dark-gold nanoswitch as a theranostic probe to sense and overcome cancer multidrug resistance [Medical Sciences]

17-Mar-2015 | João Conde; Nuria Oliva; Natalie Artzi, Proceedings of the National Academy of Sciences current issue, 2015

Multidrug resistance (MDR) in cancer cells is a substantial limitation to the success of chemotherapy. Here, we describe facile means to overcome resistance by silencing the multidrug resistance protein 1 (MRP1), before chemotherapeutic drug delivery in vivo with a single local application. Our ...

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Recurrent BCAM-AKT2 fusion gene leads to a constitutively activated AKT2 fusion kinase in high-grade serous ovarian carcinoma [Genetics]

17-Mar-2015 | Kalpana Kannan; Cristian Coarfa; Pei-Wen Chao; Liming Luo; Yan Wang; Amy E. Brinegar; Shannon M. Hawkins; Aleksandar ..., Proceedings of the National Academy of Sciences current issue, 2015

High-grade serous ovarian cancer (HGSC) is among the most lethal forms of cancer in women. Excessive genomic rearrangements, which are expected to create fusion oncogenes, are the hallmark of this cancer. Here we report a cancer-specific gene fusion between BCAM, a membrane adhesion molecule, and ...

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The RNA binding protein FXR1 is a new driver in the 3q26-29 amplicon and predicts poor prognosis in human cancers [Medical Sciences]

17-Mar-2015 | Jun Qian; Mohamed Hassanein; Megan D. Hoeksema; Bradford K. Harris; Yong Zou; Heidi Chen; Pengcheng Lu; Rosana Eisen ..., Proceedings of the National Academy of Sciences current issue, 2015

Aberrant expression of RNA-binding proteins has profound implications for cellular physiology and the pathogenesis of human diseases such as cancer. We previously identified the Fragile X-Related 1 gene (FXR1) as one amplified candidate driver gene at 3q26-29 in lung squamous cell carcinoma ...

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p63 sustains self-renewal of mammary cancer stem cells through regulation of Sonic Hedgehog signaling [Medical Sciences]

17-Mar-2015 | Elisa Maria Memmi; Anna Giulia Sanarico; Arianna Giacobbe; Angelo Peschiaroli; Valentina Frezza; Angelo Cicalese; Fe ..., Proceedings of the National Academy of Sciences current issue, 2015

The predominant p63 isoform, ΔNp63, is a master regulator of normal epithelial stem cell (SC) maintenance. However, in vivo evidence of the regulation of cancer stem cell (CSC) properties by p63 is still limited. Here, we exploit the transgenic MMTV-ErbB2 (v-erb-b2 avian erythroblastic leukemia ...

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Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity [Medical Sciences]

10-Mar-2015 | Matteo Pasetto; Antonella Antignani; Pinar Ormanoglu; Eugen Buehler; Rajarshi Guha; Ira Pastan; Scott E. Martin; Dav ..., Proceedings of the National Academy of Sciences current issue, 2015

Immunotoxins (antibody–toxin fusion proteins) target surface antigens on cancer cells and kill these cells via toxin-mediated inhibition of protein synthesis. To identify genes controlling this process, an RNAi whole-genome screen (∼22,000 genes at three siRNAs per gene) was conducted via ...

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Anticancer drug nanomicelles formed by self-assembling amphiphilic dendrimer to combat cancer drug resistance [Applied Biological Sciences]

10-Mar-2015 | Tuo Wei; Chao Chen; Juan Liu; Cheng Liu; Paola Posocco; Xiaoxuan Liu; Qiang Cheng; Shuaidong Huo; Zicai Liang; Mauri ..., Proceedings of the National Academy of Sciences current issue, 2015

Drug resistance and toxicity constitute challenging hurdles for cancer therapy. The application of nanotechnology for anticancer drug delivery is expected to address these issues and bring new hope for cancer treatment. In this context, we established an original nanomicellar drug delivery system ...

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Ligand-directed targeting of lymphatic vessels uncovers mechanistic insights in melanoma metastasis [Medical Sciences]

24-Feb-2015 | Dawn R. Christianson; Andrey S. Dobroff; Bettina Proneth; Amado J. Zurita; Ahmad Salameh; Eleonora Dondossola; Jun M ..., Proceedings of the National Academy of Sciences current issue, 2015

Metastasis is the most lethal step of cancer progression in patients with invasive melanoma. In most human cancers, including melanoma, tumor dissemination through the lymphatic vasculature provides a major route for tumor metastasis. Unfortunately, molecular mechanisms that facilitate ...

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Silencing LRH-1 in colon cancer cell lines impairs proliferation and alters gene expression programs [Cell Biology]

24-Feb-2015 | James R. Bayrer; Sridevi Mukkamala; Elena P. Sablin; Paul Webb; Robert J. Fletterick, Proceedings of the National Academy of Sciences current issue, 2015

Colorectal cancers (CRCs) account for nearly 10% of all cancer deaths in industrialized countries. Recent evidence points to a central role for the nuclear receptor liver receptor homolog-1 (LRH-1) in intestinal tumorigenesis. Interaction of LRH-1 with the Wnt/β-catenin pathway, highly active in ...

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