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656 Newest Publications in proceedings of the national academy of sciences current issue

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The tandem duplicator phenotype as a distinct genomic configuration in cancer [Genetics]

26-Apr-2016 | Francesca Menghi; Koichiro Inaki; XingYi Woo; Pooja A. Kumar; Krzysztof R. Grzeda; Ankit Malhotra; Vinod Yadav; Hyun ..., Proceedings of the National Academy of Sciences current issue, 2016

Next-generation sequencing studies have revealed genome-wide structural variation patterns in cancer, such as chromothripsis and chromoplexy, that do not engage a single discernable driver mutation, and whose clinical relevance is unclear. We devised a robust genomic metric able to identify ...

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Heterozygous colon cancer-associated mutations of SAMHD1 have functional significance [Biochemistry]

26-Apr-2016 | Matilda Rentoft; Kristoffer Lindell; Phong Tran; Anna Lena Chabes; Robert J. Buckland; Danielle L. Watt; Lisette Mar ..., Proceedings of the National Academy of Sciences current issue, 2016

Even small variations in dNTP concentrations decrease DNA replication fidelity, and this observation prompted us to analyze genomic cancer data for mutations in enzymes involved in dNTP metabolism. We found that sterile alpha motif and histidine-aspartate domain-containing protein 1 (SAMHD1), a ...

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Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides [Biochemistry]

26-Apr-2016 | Khyati Kapoor; Janet S. Finer-Moore; Bjørn P. Pedersen; Laura Caboni; Andrew Waight; Roman C. Hillig; Peter Bringman ..., Proceedings of the National Academy of Sciences current issue, 2016

Cancerous cells have an acutely increased demand for energy, leading to increased levels of human glucose transporter 1 (hGLUT1). This up-regulation suggests hGLUT1 as a target for therapeutic inhibitors addressing a multitude of cancer types. Here, we present three inhibitor-bound, inward-open ...

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Prostate epithelial cell of origin determines cancer differentiation state in an organoid transformation assay [Medical Sciences]

19-Apr-2016 | Jung Wook Park; John K. Lee; John W. Phillips; Patrick Huang; Donghui Cheng; Jiaoti Huang; Owen N. Witte, Proceedings of the National Academy of Sciences current issue, 2016

The cell of origin for prostate cancer remains a subject of debate. Genetically engineered mouse models have demonstrated that both basal and luminal cells can serve as cells of origin for prostate cancer. Using a human prostate regeneration and transformation assay, our group previously ...

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Identification of tumorigenic cells and therapeutic targets in pancreatic neuroendocrine tumors [Medical Sciences]

19-Apr-2016 | Geoffrey Wayne Krampitz; Benson M. George; Stephen B. Willingham; Jens-Peter Volkmer; Kipp Weiskopf; Nadine Jahchan; ..., Proceedings of the National Academy of Sciences current issue, 2016

Pancreatic neuroendocrine tumors (PanNETs) are a type of pancreatic cancer with limited therapeutic options. Consequently, most patients with advanced disease die from tumor progression. Current evidence indicates that a subset of cancer cells is responsible for tumor development, metastasis, and ...

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Asymmetric arginine dimethylation of RelA provides a repressive mark to modulate TNF{alpha}/NF-{kappa}B response [Biochemistry]

19-Apr-2016 | Anja Reintjes; Julian E. Fuchs; Leopold Kremser; Herbert H. Lindner; Klaus R. Liedl; Lukas A. Huber; Taras Valovka, Proceedings of the National Academy of Sciences current issue, 2016

Nuclear factor kappa B (NF-κB) is an inducible transcription factor that plays critical roles in immune and stress responses and is often implicated in pathologies, including chronic inflammation and cancer. Although much has been learned about NF-κB–activating pathways, the specific repression ...

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Paclitaxel-induced epithelial damage and ectopic MMP-13 expression promotes neurotoxicity in zebrafish [Neuroscience]

12-Apr-2016 | Thomas S. Lisse; Leah J. Middleton; Adriana D. Pellegrini; Paige B. Martin; Emily L. Spaulding; Olivia Lopes; Elizab ..., Proceedings of the National Academy of Sciences current issue, 2016

Paclitaxel is a microtubule-stabilizing chemotherapeutic agent that is widely used in cancer treatment and in a number of curative and palliative regimens. Despite its beneficial effects on cancer, paclitaxel also damages healthy tissues, most prominently the peripheral sensory nervous system. ...

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[18F]CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity [Applied Biological Sciences]

12-Apr-2016 | Woosuk Kim; Thuc M. Le; Liu Wei; Soumya Poddar; Jimmy Bazzy; Xuemeng Wang; Nhu T. Uong; Evan R. Abt; Joseph R. Capri ..., Proceedings of the National Academy of Sciences current issue, 2016

Deoxycytidine kinase (dCK), a rate-limiting enzyme in the cytosolic deoxyribonucleoside (dN) salvage pathway, is an important therapeutic and positron emission tomography (PET) imaging target in cancer. PET probes for dCK have been developed and are effective in mice but have suboptimal ...

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Endocrine vasculatures are preferable targets of an antitumor ineffective low dose of anti-VEGF therapy [Medical Sciences]

12-Apr-2016 | Yin Zhang; Yunlong Yang; Kayoko Hosaka; Guichun Huang; Jingwu Zang; Fang Chen; Yun Zhang; Nilesh J. Samani; Yihai Cao, Proceedings of the National Academy of Sciences current issue, 2016

Anti-VEGF–based antiangiogenic drugs are designed to block tumor angiogenesis for treatment of cancer patients. However, anti-VEGF drugs produce off-tumor target effects on multiple tissues and organs and cause broad adverse effects. Here, we show that vasculatures in endocrine organs were more ...

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Stimuli-responsive clustered nanoparticles for improved tumor penetration and therapeutic efficacy [Medical Sciences]

12-Apr-2016 | Hong-Jun Li; Jin-Zhi Du; Xiao-Jiao Du; Cong-Fei Xu; Chun-Yang Sun; Hong-Xia Wang; Zhi-Ting Cao; Xian-Zhu Yang; Yan-H ..., Proceedings of the National Academy of Sciences current issue, 2016

A principal goal of cancer nanomedicine is to deliver therapeutics effectively to cancer cells within solid tumors. However, there are a series of biological barriers that impede nanomedicine from reaching target cells. Here, we report a stimuli-responsive clustered nanoparticle to systematically ...

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