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474 Newest Publications in proceedings of the national academy of sciences current issue

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The AAA-ATPase molecular chaperone Cdc48/p97 disassembles sumoylated centromeres, decondenses heterochromatin, and activates ribosomal RNA genes [Plant Biology]

11-11-2014 | Zsuzsanna Mérai; Nina Chumak; Marcelina García-Aguilar; Tzung-Fu Hsieh; Toshiro Nishimura; Vera K. Schoft; János Bin ..., Proceedings of the National Academy of Sciences current issue, 2014

Centromeres mediate chromosome segregation and are defined by the centromere-specific histone H3 variant (CenH3)/centromere protein A (CENP-A). Removal of CenH3 from centromeres is a general property of terminally differentiated cells, and the persistence of CenH3 increases the risk of diseases ...

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Timing and heterogeneity of mutations associated with drug resistance in metastatic cancers [Applied Mathematics]

11-11-2014 | Ivana Bozic; Martin A. Nowak, Proceedings of the National Academy of Sciences current issue, 2014

Targeted therapies provide an exciting new approach to combat human cancer. The immediate effect is a dramatic reduction in disease burden, but in most cases, the tumor returns as a consequence of resistance. Various mechanisms for the evolution of resistance have been implicated, including ...

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A rice ABC transporter, OsABCC1, reduces arsenic accumulation in the grain [Agricultural Sciences]

04-11-2014 | Won-Yong Song; Tomohiro Yamaki; Naoki Yamaji; Donghwi Ko; Ki-Hong Jung; Miho Fujii-Kashino; Gynheung An; Enrico Mart ..., Proceedings of the National Academy of Sciences current issue, 2014

Arsenic (As) is a chronic poison that causes severe skin lesions and cancer. Rice (Oryza sativa L.) is a major dietary source of As; therefore, reducing As accumulation in the rice grain and thereby diminishing the amount of As that enters the food chain is of critical importance. Here, we...

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WWOX, the common fragile site FRA16D gene product, regulates ATM activation and the DNA damage response [Cell Biology]

04-11-2014 | Mohammad Abu-Odeh; Zaidoun Salah; Christoph Herbel; Thomas G. Hofmann; Rami I. Aqeilan, Proceedings of the National Academy of Sciences current issue, 2014

Genomic instability is a hallmark of cancer. The WW domain-containing oxidoreductase (WWOX) is a tumor suppressor spanning the common chromosomal fragile site FRA16D. Here, we report a direct role of WWOX in DNA damage response (DDR) and DNA repair. We show that Wwox deficiency results in reduced ...

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Genomic and transcriptomic analyses of the medicinal fungus Antrodia cinnamomea for its metabolite biosynthesis and sexual development [Genetics]

04-11-2014 | Mei-Yeh Jade Lu; Wen-Lang Fan; Woei-Fuh Wang; Tingchun Chen; Yi-Ching Tang; Fang-Hua Chu; Tun-Tschu Chang; Sheng-Yan ..., Proceedings of the National Academy of Sciences current issue, 2014

Antrodia cinnamomea, a polyporus mushroom of Taiwan, has long been used as a remedy for cancer, hypertension, and hangover, with an annual market of over $100 million (US) in Taiwan. We obtained a 32.15-Mb genome draft containing 9,254 genes. Genome ontology enrichment and pathway analyses shed ...

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Single-cell analyses of transcriptional heterogeneity during drug tolerance transition in cancer cells by RNA sequencing [Cell Biology]

04-11-2014 | Mei-Chong Wendy Lee; Fernando J. Lopez-Diaz; Shahid Yar Khan; Muhammad Akram Tariq; Yelena Dayn; Charles Joseph Vask ..., Proceedings of the National Academy of Sciences current issue, 2014

The acute cellular response to stress generates a subpopulation of reversibly stress-tolerant cells under conditions that are lethal to the majority of the population. Stress tolerance is attributed to heterogeneity of gene expression within the population to ensure survival of a minority. We ...

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Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial-mesenchymal transition [Medical Sciences]

28-10-2014 | Atsushi Hamabe; Masamitsu Konno; Nobuhiro Tanuma; Hiroshi Shima; Kenta Tsunekuni; Koichi Kawamoto; Naohiro Nishida; ..., Proceedings of the National Academy of Sciences current issue, 2014

Pyruvate kinase M2 (PKM2) is an alternatively spliced variant of the pyruvate kinase gene that is preferentially expressed during embryonic development and in cancer cells. PKM2 alters the final rate-limiting step of glycolysis, resulting in the cancer-specific Warburg effect (also referred to as ...

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Characterization of HPV and host genome interactions in primary head and neck cancers [Medical Sciences]

28-10-2014 | Michael Parfenov; Chandra Sekhar Pedamallu; Nils Gehlenborg; Samuel S. Freeman; Ludmila Danilova; Christopher A. Bri ..., Proceedings of the National Academy of Sciences current issue, 2014

Previous studies have established that a subset of head and neck tumors contains human papillomavirus (HPV) sequences and that HPV-driven head and neck cancers display distinct biological and clinical features. HPV is known to drive cancer by the actions of the E6 and E7 oncoproteins, but the ...

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Assessment of breast pathologies using nonlinear microscopy [Medical Sciences]

28-10-2014 | Yuankai K. Tao; Dejun Shen; Yuri Sheikine; Osman O. Ahsen; Helen H. Wang; Daniel B. Schmolze; Nicole B. Johnson; Jef ..., Proceedings of the National Academy of Sciences current issue, 2014

Rapid intraoperative assessment of breast excision specimens is clinically important because up to 40% of patients undergoing breast-conserving cancer surgery require reexcision for positive or close margins. We demonstrate nonlinear microscopy (NLM) for the assessment of benign and malignant ...

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Investigating the optimal size of anticancer nanomedicine [Engineering]

28-10-2014 | Li Tang; Xujuan Yang; Qian Yin; Kaimin Cai; Hua Wang; Isthier Chaudhury; Catherine Yao; Qin Zhou; Mincheol Kwon; Jam ..., Proceedings of the National Academy of Sciences current issue, 2014

Nanomedicines (NMs) offer new solutions for cancer diagnosis and therapy. However, extension of progression-free interval and overall survival time achieved by Food and Drug Administration-approved NMs remain modest. To develop next generation NMs to achieve superior anticancer activities, it is ...

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