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571 Newest Publications in proceedings of the national academy of sciences current issue

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EGFR inhibition evokes innate drug resistance in lung cancer cells by preventing Akt activity and thus inactivating Ets-1 function [Cell Biology]

21-Jul-2015 | Janyaporn Phuchareon; Frank McCormick; David W. Eisele; Osamu Tetsu, Proceedings of the National Academy of Sciences current issue, 2015

Nonsmall cell lung cancer (NSCLC) is the leading cause of cancer death worldwide. About 14% of NSCLCs harbor mutations in epidermal growth factor receptor (EGFR). Despite remarkable progress in treatment with tyrosine kinase inhibitors (TKIs), only 5% of patients achieve tumor reduction >90%. The ...

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Cancer in the parasitic protozoans Trypanosoma brucei and Toxoplasma gondii [Colloquium Paper]

21-Jul-2015 | Zhao-Rong Lun; De-Hua Lai; Yan-Zi Wen; Ling-Ling Zheng; Ji-Long Shen; Ting-Bo Yang; Wen-Liang Zhou; Liang-Hu Qu; Geo ..., Proceedings of the National Academy of Sciences current issue, 2015

Cancer is a general name for more than 100 malignant diseases. It is postulated that all cancers start from a single abnormal cell that grows out of control. Untreated cancers can cause serious consequences and deaths. Great progress has been made in cancer research that has significantly ...

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Jagged mediates differences in normal and tumor angiogenesis by affecting tip-stalk fate decision [Biophysics and Computational Biology]

21-Jul-2015 | Marcelo Boareto; Mohit Kumar Jolly; Eshel Ben-Jacob; José N. Onuchic, Proceedings of the National Academy of Sciences current issue, 2015

Angiogenesis is critical during development, wound repair, and cancer progression. During angiogenesis, some endothelial cells adopt a tip phenotype to lead the formation of new branching vessels; the trailing stalk cells proliferate to develop the vessel. Notch and VEGF signaling mediate the ...

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Preventing clonal evolutionary processes in cancer: Insights from mathematical models [Colloquium Paper]

21-Jul-2015 | Ignacio A. Rodriguez-Brenes; Dominik Wodarz, Proceedings of the National Academy of Sciences current issue, 2015

Clonal evolutionary processes can drive pathogenesis in human diseases, with cancer being a prominent example. To prevent or treat cancer, mechanisms that can potentially interfere with clonal evolutionary processes need to be understood better. Mathematical modeling is an important research tool ...

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Stem cells are units of natural selection for tissue formation, for germline development, and in cancer development [Colloquium Paper]

21-Jul-2015 | Irving L. Weissman, Proceedings of the National Academy of Sciences current issue, 2015

It is obvious that natural selection operates at the level of individuals and collections of individuals. Nearly two decades ago we showed that in multi-individual colonies of protochordate colonial tunicates sharing a blood circulation, there exists an exchange of somatic stem cells and germline ...

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Toward an evolutionary model of cancer: Considering the mechanisms that govern the fate of somatic mutations [Colloquium Paper]

21-Jul-2015 | Andrii I. Rozhok; James DeGregori, Proceedings of the National Academy of Sciences current issue, 2015

Our understanding of cancer has greatly advanced since Nordling [Nordling CO (1953) Br J Cancer 7(1):68–72] and Armitage and Doll [Armitage P, Doll R (1954) Br J Cancer 8(1):1–12] put forth the multistage model of carcinogenesis. However, a number of observations remain poorly understood from the ...

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Magnetic levitation of single cells [Applied Biological Sciences]

14-Jul-2015 | Naside Gozde Durmus; H. Cumhur Tekin; Sinan Guven; Kaushik Sridhar; Ahu Arslan Yildiz; Gizem Calibasi; Ionita Ghiran ..., Proceedings of the National Academy of Sciences current issue, 2015

Several cellular events cause permanent or transient changes in inherent magnetic and density properties of cells. Characterizing these changes in cell populations is crucial to understand cellular heterogeneity in cancer, immune response, infectious diseases, drug resistance, and evolution. ...

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Tissue stiffness regulates serine/arginine-rich protein-mediated splicing of the extra domain B-fibronectin isoform in tumors [Applied Physical Sciences]

07-Jul-2015 | Francois Bordeleau; Joseph P. Califano; Yashira L. Negrón Abril; Brooke N. Mason; Danielle J. LaValley; Sandra J. Sh ..., Proceedings of the National Academy of Sciences current issue, 2015

Alternative splicing of proteins gives rise to different isoforms that play a crucial role in regulating several cellular processes. Notably, splicing profiles are altered in several cancer types, and these profiles are believed to be involved in driving the oncogenic process. Although the ...

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Structural insights into the recognition of cisplatin and AAF-dG lesion by Rad14 (XPA) [Chemistry]

07-Jul-2015 | Sandra C. Koch; Jochen Kuper; Karola L. Gasteiger; Nina Simon; Ralf Strasser; David Eisen; Simon Geiger; Sabine Schn ..., Proceedings of the National Academy of Sciences current issue, 2015

Nucleotide excision repair (NER) is responsible for the removal of a large variety of structurally diverse DNA lesions. Mutations of the involved proteins cause the xeroderma pigmentosum (XP) cancer predisposition syndrome. Although the general mechanism of the NER process is well studied, the ...

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Reply to Ciccolini et al.: Using mathematical modeling to predict response to antiangiogenic therapy in cancer patients [Biological Sciences]

07-Jul-2015 | Dan G. Duda; Rebecca S. Heist; Dushyant V. Sahani; Triantafyllos Stylianopoulos; Jeffrey A. Engelman; Rakesh K. Jain, Proceedings of the National Academy of Sciences current issue, 2015

We thank Ciccolini et al. (1) for their interest in our report (2) on a clinical study, published recently in PNAS. In that paper, we report that improved tumor vascular function after anti-VEGF therapy with carboplatin and nab-paclitaxel associates with survival in non-small cell lung cancer ...

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