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534 Newest Publications in proceedings of the national academy of sciences current issue

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Oncogenesis driven by the Ras/Raf pathway requires the SUMO E2 ligase Ubc9 [Cell Biology]

07-Apr-2015 | Bing Yu; Stephen Swatkoski; Alesia Holly; Liam C. Lee; Valentin Giroux; Chih-Shia Lee; Dennis Hsu; Jordan L. Smith; ..., Proceedings of the National Academy of Sciences current issue, 2015

The small GTPase KRAS is frequently mutated in human cancer and currently there are no targeted therapies for KRAS mutant tumors. Here, we show that the small ubiquitin-like modifier (SUMO) pathway is required for KRAS-driven transformation. RNAi depletion of the SUMO E2 ligase Ubc9 suppresses 3D ...

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Inversion of Sonic hedgehog action on its canonical pathway by electrical activity [Neuroscience]

31-Mar-2015 | Yesser H. Belgacem; Laura N. Borodinsky, Proceedings of the National Academy of Sciences current issue, 2015

Sonic hedgehog (Shh) is a morphogenic protein that operates through the Gli transcription factor-dependent canonical pathway to orchestrate normal development of many tissues. Because aberrant levels of Gli activity lead to a wide spectrum of diseases ranging from neurodevelopmental defects to ...

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Regulation of Nrf2 signaling and longevity in naturally long-lived rodents [Cell Biology]

24-Mar-2015 | Kaitlyn N. Lewis; Emily Wason; Yael H. Edrey; Deborah M. Kristan; Eviatar Nevo; Rochelle Buffenstein, Proceedings of the National Academy of Sciences current issue, 2015

The preternaturally long-lived naked mole-rat, like other long-lived species and experimental models of extended longevity, is resistant to both endogenous (e.g., reactive oxygen species) and environmental stressors and also resists age-related diseases such as cancer, cardiovascular disease, and ...

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The Fe-S cluster-containing NEET proteins mitoNEET and NAF-1 as chemotherapeutic targets in breast cancer [Chemistry]

24-Mar-2015 | Fang Bai; Faruck Morcos; Yang-Sung Sohn; Merav Darash-Yahana; Celso O. Rezende; Colin H. Lipper; Mark L. Paddock; Lu ..., Proceedings of the National Academy of Sciences current issue, 2015

Identification of novel drug targets and chemotherapeutic agents is a high priority in the fight against cancer. Here, we report that MAD-28, a designed cluvenone (CLV) derivative, binds to and destabilizes two members of a unique class of mitochondrial and endoplasmic reticulum (ER) 2Fe-2S ...

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Implications of xenoglycan sensitivity for increased cancer risk [Biological Sciences]

24-Mar-2015 | Kimberley J. Mackenzie, Proceedings of the National Academy of Sciences current issue, 2015

The excellent study by Samraj et al. (1) shows that dietary intake of the nonhuman sialic acid N-glycolylneuraminic acid (Neu5Gc) promotes the production of anti-Neu5Gc antibodies. The resulting “xenosialitis” and associated chronic inflammation was shown to contribute to carcinogenesis. This ...

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Functionally conserved architecture of hepatitis C virus RNA genomes [Biochemistry]

24-Mar-2015 | David M. Mauger; Michael Golden; Daisuke Yamane; Sara Williford; Stanley M. Lemon; Darren P. Martin; Kevin M. Weeks, Proceedings of the National Academy of Sciences current issue, 2015

Hepatitis C virus (HCV) infects over 170 million people worldwide and is a leading cause of liver disease and cancer. The virus has a 9,650-nt, single-stranded, messenger-sense RNA genome that is infectious as an independent entity. The RNA genome has evolved in response to complex selection ...

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Reply to Mackenzie: A comparison of Neu5Gc and {alpha}-gal xenoantigens [Biological Sciences]

24-Mar-2015 | Oliver M. T. Pearce; Annie N. Samraj; Heinz Läubli; Nissi M. Varki; Ajit Varki, Proceedings of the National Academy of Sciences current issue, 2015

We appreciate the thoughtful comments of K. J. Mackenzie (1) regarding our findings, concerning how a red meat-derived glycan can promote inflammation and cancer progression (2). At first glance, there do indeed appear to be very close similarities between the nonhuman sialic acid ...

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Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer [Medical Sciences]

17-Mar-2015 | Anthony C. Faber; Anna F. Farago; Carlotta Costa; Anahita Dastur; Maria Gomez-Caraballo; Rebecca Robbins; Bethany L. ..., Proceedings of the National Academy of Sciences current issue, 2015

BH3 mimetics such as ABT-263 induce apoptosis in a subset of cancer models. However, these drugs have shown limited clinical efficacy as single agents in small-cell lung cancer (SCLC) and other solid tumor malignancies, and rational combination strategies remain underexplored. To develop a novel ...

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Implantable hydrogel embedded dark-gold nanoswitch as a theranostic probe to sense and overcome cancer multidrug resistance [Medical Sciences]

17-Mar-2015 | João Conde; Nuria Oliva; Natalie Artzi, Proceedings of the National Academy of Sciences current issue, 2015

Multidrug resistance (MDR) in cancer cells is a substantial limitation to the success of chemotherapy. Here, we describe facile means to overcome resistance by silencing the multidrug resistance protein 1 (MRP1), before chemotherapeutic drug delivery in vivo with a single local application. Our ...

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Recurrent BCAM-AKT2 fusion gene leads to a constitutively activated AKT2 fusion kinase in high-grade serous ovarian carcinoma [Genetics]

17-Mar-2015 | Kalpana Kannan; Cristian Coarfa; Pei-Wen Chao; Liming Luo; Yan Wang; Amy E. Brinegar; Shannon M. Hawkins; Aleksandar ..., Proceedings of the National Academy of Sciences current issue, 2015

High-grade serous ovarian cancer (HGSC) is among the most lethal forms of cancer in women. Excessive genomic rearrangements, which are expected to create fusion oncogenes, are the hallmark of this cancer. Here we report a cancer-specific gene fusion between BCAM, a membrane adhesion molecule, and ...

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