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458 Newest Publications in proceedings of the national academy of sciences current issue

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Seriniquinone, a selective anticancer agent, induces cell death by autophagocytosis, targeting the cancer-protective protein dermcidin [Pharmacology]

14-10-2014 | Lynnie Trzoss; Takashi Fukuda; Letícia V. Costa-Lotufo; Paula Jimenez; James J. La Clair; William Fenical, Proceedings of the National Academy of Sciences current issue, 2014

Natural products continue to provide vital treatment options for cancer. Although their translation into chemotherapeutics is complex, collaborative programs continue to deliver productive pipelines for cancer chemotherapy. A new natural product, seriniquinone, isolated from a marine bacterium of ...

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MAGI-2 scaffold protein is critical for kidney barrier function [Medical Sciences]

14-10-2014 | Minna D. Balbas; Michael R. Burgess; Rajmohan Murali; John Wongvipat; Brian J. Skaggs; Peter Mundel; Astrid Weins; C ..., Proceedings of the National Academy of Sciences current issue, 2014

MAGUK Inverted 2 (MAGI-2) is a PTEN-interacting scaffold protein implicated in cancer on the basis of rare, recurrent genomic translocations and deletions in various tumors. In the renal glomerulus, MAGI-2 is exclusively expressed in podocytes, specialized cells forming part of the glomerular ...

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Basal p21 controls population heterogeneity in cycling and quiescent cell cycle states [Systems Biology]

14-10-2014 | K. Wesley Overton; Sabrina L. Spencer; William L. Noderer; Tobias Meyer; Clifford L. Wang, Proceedings of the National Academy of Sciences current issue, 2014

Phenotypic heterogeneity within a population of genetically identical cells is emerging as a common theme in multiple biological systems, including human cell biology and cancer. Using live-cell imaging, flow cytometry, and kinetic modeling, we showed that two states—quiescence and cell ...

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Quantitative and stoichiometric analysis of the microRNA content of exosomes [Medical Sciences]

14-10-2014 | John R. Chevillet; Qing Kang; Ingrid K. Ruf; Hilary A. Briggs; Lucia N. Vojtech; Sean M. Hughes; Heather H. Cheng; J ..., Proceedings of the National Academy of Sciences current issue, 2014

Exosomes have been proposed as vehicles for microRNA (miRNA) -based intercellular communication and a source of miRNA biomarkers in bodily fluids. Although exosome preparations contain miRNAs, a quantitative analysis of their abundance and stoichiometry is lacking. In the course of studying ...

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Modeling putative therapeutic implications of exosome exchange between tumor and immune cells [Biophysics and Computational Biology]

07-10-2014 | Mingyang Lu; Bin Huang; Samir M. Hanash; José N. Onuchic; Eshel Ben-Jacob, Proceedings of the National Academy of Sciences current issue, 2014

Development of effective strategies to mobilize the immune system as a therapeutic modality in cancer necessitates a better understanding of the contribution of the tumor microenvironment to the complex interplay between cancer cells and the immune response. Recently, effort has been directed at ...

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Cell fate regulation by gelsolin in human gynecologic cancers [Cell Biology]

07-10-2014 | Mohammad R. Abedini; Pei-Wen Wang; Yu-Fang Huang; Mingju Cao; Cheng-Yang Chou; Dar-Bin Shieh; Benjamin K. Tsang, Proceedings of the National Academy of Sciences current issue, 2014

Chemoresistance is a major hurdle in cancer treatment. Down-regulation of apoptosis pathways is one of the key determinants for chemoresistance. Here, we report higher gelsolin (GSN) levels in chemoresistant gynecological cancer cells compared with their sensitive counterparts. cis-Diammine ...

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Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET [Cell Biology]

16-09-2014 | Erinn B. Rankin; Katherine C. Fuh; Laura Castellini; Kartik Viswanathan; Elizabeth C. Finger; Anh N. Diep; Edward L. ..., Proceedings of the National Academy of Sciences current issue, 2014

Dysregulation of the von Hippel–Lindau/hypoxia-inducible transcription factor (HIF) signaling pathway promotes clear cell renal cell carcinoma (ccRCC) progression and metastasis. The protein kinase GAS6/AXL signaling pathway has recently been implicated as an essential mediator of metastasis and ...

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Phospholipase C{delta}1 induces E-cadherin expression and suppresses malignancy in colorectal cancer cells [Medical Sciences]

16-09-2014 | Reiko Satow; Tamaki Hirano; Ryosuke Batori; Tomomi Nakamura; Yumi Murayama; Kiyoko Fukami, Proceedings of the National Academy of Sciences current issue, 2014

Colorectal cancer (CRC) is one of the most common causes of cancer-related deaths worldwide, and Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations in CRC predict the ineffectiveness of EGF receptor-targeted therapy. Previous transcriptional microarray analysis suggests the association ...

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Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress [Genetics]

16-09-2014 | Floris Foijer; Stephanie Z. Xie; Judith E. Simon; Petra L. Bakker; Nathalie Conte; Stephanie H. Davis; Eva Kregel; J ..., Proceedings of the National Academy of Sciences current issue, 2014

Aneuploidy is a hallmark of human solid cancers that arises from errors in mitosis and results in gain and loss of oncogenes and tumor suppressors. Aneuploidy poses a growth disadvantage for cells grown in vitro, suggesting that cancer cells adapt to this burden. To understand better the ...

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Unfolded protein response activation reduces secretion and extracellular aggregation of amyloidogenic immunoglobulin light chain [Biochemistry]

09-09-2014 | Christina B. Cooley; Lisa M. Ryno; Lars Plate; Gareth J. Morgan; John D. Hulleman; Jeffery W. Kelly; R. Luke Wiseman, Proceedings of the National Academy of Sciences current issue, 2014

Light-chain amyloidosis (AL) is a degenerative disease characterized by the extracellular aggregation of a destabilized amyloidogenic Ig light chain (LC) secreted from a clonally expanded plasma cell. Current treatments for AL revolve around ablating the cancer plasma cell population using ...

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