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463 Newest Publications in proceedings of the national academy of sciences current issue

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Reply to Leithner et al.: Focus on phopshoenolpyruvate carboxykinase (PEPCK): A target of the p53-SIRT6-FoxO1 axis [Biological Sciences]

21-10-2014 | Zhiming Li; Wei-Guo Zhu, Proceedings of the National Academy of Sciences current issue, 2014

Cancer metabolism has drawn widespread attention since the unique metabolic properties of cancer cells were characterized. We found that p53, a potent tumor suppressor, down-regulates the expression of phopshoenolpyruvate carboxykinase (PEPCK, PCK1) in coordination with histone deacetylase ...

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Label-free electrochemical detection of human methyltransferase from tumors [Biochemistry]

21-10-2014 | Ariel L. Furst; Natalie B. Muren; Michael G. Hill; Jacqueline K. Barton, Proceedings of the National Academy of Sciences current issue, 2014

The role of abnormal DNA methyltransferase activity in the development and progression of cancer is an essential and rapidly growing area of research, both for improved diagnosis and treatment. However, current technologies for the assessment of methyltransferase activity, particularly from crude ...

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Gluconeogenesis in cancer: Door wide open [Biological Sciences]

21-10-2014 | Katharina Leithner; Andelko Hrzenjak; Horst Olschewski, Proceedings of the National Academy of Sciences current issue, 2014

Zhang et al. (1) make a valuable contribution to the field of cancer metabolism, showing that the tumor suppressor p53 down-regulates the gluconeogenic key enzyme phosphoenolpyruvate carboxykinase (PEPCK, PCK1) via histone deacetylase sirtuin 6. The authors conclude that inhibition of ...

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Tug-of-war between driver and passenger mutations in cancer and other adaptive processes [Evolution]

21-10-2014 | Christopher D. McFarland; Leonid A. Mirny; Kirill S. Korolev, Proceedings of the National Academy of Sciences current issue, 2014

Cancer progression is an example of a rapid adaptive process where evolving new traits is essential for survival and requires a high mutation rate. Precancerous cells acquire a few key mutations that drive rapid population growth and carcinogenesis. Cancer genomics demonstrates that these few ...

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Identification and characterization of alphavirus M1 as a selective oncolytic virus targeting ZAP-defective human cancers [Medical Sciences]

21-10-2014 | Yuan Lin; Haipeng Zhang; Jiankai Liang; Kai Li; Wenbo Zhu; Liwu Fu; Fang Wang; Xiaoke Zheng; Huijuan Shi; Sihan Wu; ..., Proceedings of the National Academy of Sciences current issue, 2014

Oncolytic virotherapy is a growing treatment modality that uses replicating viruses as selective antineoplastic agents. Safety and efficacy considerations dictate that an ideal oncolytic agent would discriminate between normal and cancer cells on the basis of common genetic abnormalities in human ...

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Seriniquinone, a selective anticancer agent, induces cell death by autophagocytosis, targeting the cancer-protective protein dermcidin [Pharmacology]

14-10-2014 | Lynnie Trzoss; Takashi Fukuda; Letícia V. Costa-Lotufo; Paula Jimenez; James J. La Clair; William Fenical, Proceedings of the National Academy of Sciences current issue, 2014

Natural products continue to provide vital treatment options for cancer. Although their translation into chemotherapeutics is complex, collaborative programs continue to deliver productive pipelines for cancer chemotherapy. A new natural product, seriniquinone, isolated from a marine bacterium of ...

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MAGI-2 scaffold protein is critical for kidney barrier function [Medical Sciences]

14-10-2014 | Minna D. Balbas; Michael R. Burgess; Rajmohan Murali; John Wongvipat; Brian J. Skaggs; Peter Mundel; Astrid Weins; C ..., Proceedings of the National Academy of Sciences current issue, 2014

MAGUK Inverted 2 (MAGI-2) is a PTEN-interacting scaffold protein implicated in cancer on the basis of rare, recurrent genomic translocations and deletions in various tumors. In the renal glomerulus, MAGI-2 is exclusively expressed in podocytes, specialized cells forming part of the glomerular ...

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Basal p21 controls population heterogeneity in cycling and quiescent cell cycle states [Systems Biology]

14-10-2014 | K. Wesley Overton; Sabrina L. Spencer; William L. Noderer; Tobias Meyer; Clifford L. Wang, Proceedings of the National Academy of Sciences current issue, 2014

Phenotypic heterogeneity within a population of genetically identical cells is emerging as a common theme in multiple biological systems, including human cell biology and cancer. Using live-cell imaging, flow cytometry, and kinetic modeling, we showed that two states—quiescence and cell ...

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Quantitative and stoichiometric analysis of the microRNA content of exosomes [Medical Sciences]

14-10-2014 | John R. Chevillet; Qing Kang; Ingrid K. Ruf; Hilary A. Briggs; Lucia N. Vojtech; Sean M. Hughes; Heather H. Cheng; J ..., Proceedings of the National Academy of Sciences current issue, 2014

Exosomes have been proposed as vehicles for microRNA (miRNA) -based intercellular communication and a source of miRNA biomarkers in bodily fluids. Although exosome preparations contain miRNAs, a quantitative analysis of their abundance and stoichiometry is lacking. In the course of studying ...

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Modeling putative therapeutic implications of exosome exchange between tumor and immune cells [Biophysics and Computational Biology]

07-10-2014 | Mingyang Lu; Bin Huang; Samir M. Hanash; José N. Onuchic; Eshel Ben-Jacob, Proceedings of the National Academy of Sciences current issue, 2014

Development of effective strategies to mobilize the immune system as a therapeutic modality in cancer necessitates a better understanding of the contribution of the tumor microenvironment to the complex interplay between cancer cells and the immune response. Recently, effort has been directed at ...

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