My watch list
my.chemeurope.com  
Login  

491 Newest Publications in proceedings of the national academy of sciences current issue

rss
matching the following criteria

TSPAN12 is a critical factor for cancer-fibroblast cell contact-mediated cancer invasion [Medical Sciences]

30-Dec-2014 | Ryo Otomo; Chihiro Otsubo; Yuko Matsushima-Hibiya; Makoto Miyazaki; Fumio Tashiro; Hitoshi Ichikawa; Takashi Kohno; ..., Proceedings of the National Academy of Sciences current issue, 2014

Communication between cancer cells and their microenvironment controls cancer progression. Although the tumor suppressor p53 functions in a cell-autonomous manner, it has also recently been shown to function in a non–cell-autonomous fashion. Although functional defects have been reported in p53 ...

more

In vivo anticancer activity of rhomboidal Pt(II) metallacycles [Chemistry]

30-Dec-2014 | Ivan V. Grishagin; J. Bryant Pollock; Swati Kushal; Timothy R. Cook; Peter J. Stang; Bogdan Z. Olenyuk, Proceedings of the National Academy of Sciences current issue, 2014

The development of novel antitumor agents that have high efficacy in suppressing tumor growth, have low toxicity to nontumor tissues, and exhibit rapid localization in the targeted tumor sites is an ongoing avenue of research at the interface of chemistry, cancer biology, and pharmacology. ...

more

A long noncoding RNA connects c-Myc to tumor metabolism [Medical Sciences]

30-Dec-2014 | Chiu-Lien Hung; Ling-Yu Wang; Yen-Ling Yu; Hong-Wu Chen; Shiv Srivastava; Gyorgy Petrovics; Hsing-Jien Kung, Proceedings of the National Academy of Sciences current issue, 2014

Long noncoding RNAs (lncRNAs) have been implicated in a variety of physiological and pathological processes, including cancer. In prostate cancer, prostate cancer gene expression marker 1 (PCGEM1) is an androgen-induced prostate-specific lncRNA whose overexpression is highly associated with ...

more

In vivo selective cancer-tracking gadolinium eradicator as new-generation photodynamic therapy agent [Chemistry]

23-Dec-2014 | Tao Zhang; Rongfeng Lan; Chi-Fai Chan; Ga-Lai Law; Wai-Kwok Wong; Ka-Leung Wong, Proceedings of the National Academy of Sciences current issue, 2014

In this work, we demonstrate a modality of photodynamic therapy (PDT) through the design of our truly dual-functional—PDT and imaging—gadolinium complex (Gd-N), which can target cancer cells specifically. In the light of our design, the PDT drug can specifically localize on the anionic cell ...

more

Automated analysis of immunohistochemistry images identifies candidate location biomarkers for cancers [Biophysics and Computational Biology]

23-Dec-2014 | Aparna Kumar; Arvind Rao; Santosh Bhavani; Justin Y. Newberg; Robert F. Murphy, Proceedings of the National Academy of Sciences current issue, 2014

Molecular biomarkers are changes measured in biological samples that reflect disease states. Such markers can help clinicians identify types of cancer or stages of progression, and they can guide in tailoring specific therapies. Many efforts to identify biomarkers consider genes that mutate ...

more

Repurposing of bisphosphonates for the prevention and therapy of nonsmall cell lung and breast cancer [Medical Sciences]

16-Dec-2014 | Agnes Stachnik; Tony Yuen; Jameel Iqbal; Miriam Sgobba; Yogesh Gupta; Ping Lu; Graziana Colaianni; Yaoting Ji; Ling- ..., Proceedings of the National Academy of Sciences current issue, 2014

A variety of human cancers, including nonsmall cell lung (NSCLC), breast, and colon cancers, are driven by the human epidermal growth factor receptor (HER) family of receptor tyrosine kinases. Having shown that bisphosphonates, a class of drugs used widely for the therapy of osteoporosis and ...

more

Bisphosphonates inactivate human EGFRs to exert antitumor actions [Medical Sciences]

16-Dec-2014 | Tony Yuen; Agnes Stachnik; Jameel Iqbal; Miriam Sgobba; Yogesh Gupta; Ping Lu; Graziana Colaianni; Yaoting Ji; Ling- ..., Proceedings of the National Academy of Sciences current issue, 2014

Bisphosphonates are the most commonly prescribed medicines for osteoporosis and skeletal metastases. The drugs have also been shown to reduce cancer progression, but only in certain patient subgroups, suggesting that there is a molecular entity that mediates bisphosphonate action on tumor cells. ...

more

Fibroblasts probe substrate rigidity with filopodia extensions before occupying an area [Biophysics and Computational Biology]

02-Dec-2014 | Stephanie Wong; Wei-Hui Guo; Yu-Li Wang, Proceedings of the National Academy of Sciences current issue, 2014

Rigidity sensing and durotaxis are thought to be important elements in wound healing, tissue formation, and cancer treatment. It has been challenging, however, to study the underlying mechanism due to difficulties in capturing cells during the transient response to a rigidity interface. We have ...

more

Topoisomerase 1 inhibition reversibly impairs synaptic function [Neuroscience]

02-Dec-2014 | Angela M. Mabb; Paul H. M. Kullmann; Margaret A. Twomey; Jayalakshmi Miriyala; Benjamin D. Philpot; Mark J. Zylka, Proceedings of the National Academy of Sciences current issue, 2014

Topotecan is a topoisomerase 1 (TOP1) inhibitor that is used to treat various forms of cancer. We recently found that topotecan reduces the expression of multiple long genes, including many neuronal genes linked to synapses and autism. However, whether topotecan alters synaptic protein levels and ...

more

NanoFlares for the detection, isolation, and culture of live tumor cells from human blood [Applied Biological Sciences]

02-Dec-2014 | Tiffany L. Halo; Kaylin M. McMahon; Nicholas L. Angeloni; Yilin Xu; Wei Wang; Alyssa B. Chinen; Dmitry Malin; Elena ..., Proceedings of the National Academy of Sciences current issue, 2014

Metastasis portends a poor prognosis for cancer patients. Primary tumor cells disseminate through the bloodstream before the appearance of detectable metastatic lesions. The analysis of cancer cells in blood—so-called circulating tumor cells (CTCs)—may provide unprecedented opportunities for ...

more

Page 1 From 50
Subscribe to e-mail updates relating to your search

You will receive via e-mail the latest search results matching your search criteria. This service is free of charge and can be cancelled at any time.

Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE