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547 Newest Publications in proceedings of the national academy of sciences current issue

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QnAs with Patrick Moore [QnAs]

12-May-2015 | Jennifer Viegas, Proceedings of the National Academy of Sciences current issue, 2015

Since its inception just over a century ago, the field of tumor virology has provided insights into the causes for many cancers. Patrick Moore, director of the Cancer Virology Program at the University of Pittsburgh, is a leading contributor to the field, having codiscovered two of the seven ...

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Completion of the seven-step pathway from tabersonine to the anticancer drug precursor vindoline and its assembly in yeast [Plant Biology]

12-May-2015 | Yang Qu; Michael L. A. E. Easson; Jordan Froese; Razvan Simionescu; Tomas Hudlicky; Vincenzo De Luca, Proceedings of the National Academy of Sciences current issue, 2015

Antitumor substances related to vinblastine and vincristine are exclusively found in the Catharanthus roseus (Madagascar periwinkle), a member of the Apocynaceae plant family, and continue to be extensively used in cancer chemotherapy. Although in high demand, these valuable compounds only ...

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Architecture and migration of an epithelium on a cylindrical wire [Biophysics and Computational Biology]

12-May-2015 | Hannah G. Yevick; Guillaume Duclos; Isabelle Bonnet; Pascal Silberzan, Proceedings of the National Academy of Sciences current issue, 2015

In a wide range of epithelial tissues such as kidney tubules or breast acini, cells organize into bidimensional monolayers experiencing an out-of-plane curvature. Cancer cells can also migrate collectively from epithelial tumors by wrapping around vessels or muscle fibers. However, in vitro ...

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Major reorientation of tRNA substrates defines specificity of dihydrouridine synthases [Biochemistry]

12-May-2015 | Robert T. Byrne; Huw T. Jenkins; Daniel T. Peters; Fiona Whelan; James Stowell; Naveed Aziz; Pavel Kasatsky; Marina ..., Proceedings of the National Academy of Sciences current issue, 2015

The reduction of specific uridines to dihydrouridine is one of the most common modifications in tRNA. Increased levels of the dihydrouridine modification are associated with cancer. Dihydrouridine synthases (Dus) from different subfamilies selectively reduce distinct uridines, located at ...

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Colon cancer-associated mutator DNA polymerase {delta} variant causes expansion of dNTP pools increasing its own infidelity [Genetics]

12-May-2015 | Tony M. Mertz; Sushma Sharma; Andrei Chabes; Polina V. Shcherbakova, Proceedings of the National Academy of Sciences current issue, 2015

Defects in DNA polymerases δ (Polδ) and ε (Polε) cause hereditary colorectal cancer and have been implicated in the etiology of some sporadic colorectal and endometrial tumors. We previously reported that the yeast pol3-R696W allele mimicking a human cancer-associated variant, POLD1-R689W, causes ...

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Head-to-head antisense transcription and R-loop formation promotes transcriptional activation [Genetics]

05-May-2015 | Raquel Boque-Sastre; Marta Soler; Cristina Oliveira-Mateos; Anna Portela; Catia Moutinho; Sergi Sayols; Alberto Vill ..., Proceedings of the National Academy of Sciences current issue, 2015

The mechanisms used by antisense transcripts to regulate their corresponding sense mRNAs are not fully understood. Herein, we have addressed this issue for the vimentin (VIM) gene, a member of the intermediate filament family involved in cell and tissue integrity that is deregulated in different ...

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In This Issue [This Week in PNAS]

05-May-2015 | Proceedings of the National Academy of Sciences current issue, 2015

Rapid cancer diagnosis through diffraction analysis Digital diffraction diagnosis platform. Digital holography can help perform rapid, reliable, and unencumbered cancer diagnosis at points of care, particularly in resource-poor settings. Hyungsoon Im et al. (pp. 5613–5618) developed an assay ...

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Enhancing the antitumor efficacy of a cell-surface death ligand by covalent membrane display [Biochemistry]

05-May-2015 | Pradeep M. Nair; Heather Flores; Alvin Gogineni; Scot Marsters; David A. Lawrence; Robert F. Kelley; Hai Ngu; Meredi ..., Proceedings of the National Academy of Sciences current issue, 2015

TNF superfamily death ligands are expressed on the surface of immune cells and can trigger apoptosis in susceptible cancer cells by engaging cognate death receptors. A recombinant soluble protein comprising the ectodomain of Apo2 ligand/TNF-related apoptosis-inducing ligand (Apo2L/TRAIL) has ...

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Enhancement of radiation effect on cancer cells by gold-pHLIP [Applied Biological Sciences]

28-Apr-2015 | Michael P. Antosh; Dayanjali D. Wijesinghe; Samana Shrestha; Robert Lanou; Yun Hu Huang; Thomas Hasselbacher; David ..., Proceedings of the National Academy of Sciences current issue, 2015

Previous research has shown that gold nanoparticles can increase the effectiveness of radiation on cancer cells. Improved radiation effectiveness would allow lower radiation doses given to patients, reducing adverse effects; alternatively, it would provide more cancer killing at current radiation ...

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Multifunctional bioscaffolds for 3D culture of melanoma cells reveal increased MMP activity and migration with BRAF kinase inhibition [Applied Biological Sciences]

28-Apr-2015 | Jennifer L. Leight; Emi Y. Tokuda; Caitlin E. Jones; Austin J. Lin; Kristi S. Anseth, Proceedings of the National Academy of Sciences current issue, 2015

Matrix metalloproteinases (MMPs) are important for many different types of cancer-related processes, including metastasis. Understanding the functional impact of changes in MMP activity during cancer treatment is an important facet not typically evaluated as part of preclinical research. With MMP ...

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