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582 Newest Publications in proceedings of the national academy of sciences current issue

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Ablation of XP-V gene causes adipose tissue senescence and metabolic abnormalities [Genetics]

18-Aug-2015 | Yih-Wen Chen; Robert A. Harris; Zafer Hatahet; Kai-ming Chou, Proceedings of the National Academy of Sciences current issue, 2015

Obesity and the metabolic syndrome have evolved to be major health issues throughout the world. Whether loss of genome integrity contributes to this epidemic is an open question. DNA polymerase η (pol η), encoded by the xeroderma pigmentosum (XP-V) gene, plays an essential role in preventing ...

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Generation of knock-in primary human T cells using Cas9 ribonucleoproteins [Immunology and Inflammation]

18-Aug-2015 | Kathrin Schumann; Steven Lin; Eric Boyer; Dimitre R. Simeonov; Meena Subramaniam; Rachel E. Gate; Genevieve E. Halib ..., Proceedings of the National Academy of Sciences current issue, 2015

T-cell genome engineering holds great promise for cell-based therapies for cancer, HIV, primary immune deficiencies, and autoimmune diseases, but genetic manipulation of human T cells has been challenging. Improved tools are needed to efficiently “knock out” genes and “knock in” targeted genome ...

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Ancient hot and cold genes and chemotherapy resistance emergence [Physics]

18-Aug-2015 | Amy Wu; Qiucen Zhang; Guillaume Lambert; Zayar Khin; Robert A. Gatenby; Hyunsung John Kim; Nader Pourmand; Kimberly ..., Proceedings of the National Academy of Sciences current issue, 2015

We use a microfabricated ecology with a doxorubicin gradient and population fragmentation to produce a strong Darwinian selective pressure that drives forward the rapid emergence of doxorubicin resistance in multiple myeloma (MM) cancer cells. RNA sequencing of the resistant cells was used to ...

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MicroRNA-224 promotes tumor progression in nonsmall cell lung cancer [Medical Sciences]

04-Aug-2015 | Ri Cui; Wei Meng; Hui-Lung Sun; Taewan Kim; Zhenqing Ye; Matteo Fassan; Young-Jun Jeon; Bin Li; Caterina Vicentini; ..., Proceedings of the National Academy of Sciences current issue, 2015

Lung cancer is the leading cause of cancer-related deaths worldwide. Despite advancements and improvements in surgical and medical treatments, the survival rate of lung cancer patients remains frustratingly poor. Local control for early-stage nonsmall cell lung cancer (NSCLC) has dramatically ...

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Detection of tumor-derived DNA in cerebrospinal fluid of patients with primary tumors of the brain and spinal cord [Medical Sciences]

04-Aug-2015 | Yuxuan Wang; Simeon Springer; Ming Zhang; K. Wyatt McMahon; Isaac Kinde; Lisa Dobbyn; Janine Ptak; Henry Brem; Kaiso ..., Proceedings of the National Academy of Sciences current issue, 2015

Cell-free DNA shed by cancer cells has been shown to be a rich source of putative tumor-specific biomarkers. Because cell-free DNA from brain and spinal cord tumors cannot usually be detected in the blood, we studied whether the cerebrospinal fluid (CSF) that bathes the CNS is enriched for tumor ...

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Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer's disease [Chemistry]

04-Aug-2015 | Xueli Zhang; Yanli Tian; Can Zhang; Xiaoyu Tian; Alana W. Ross; Robert D. Moir; Hongbin Sun; Rudolph E. Tanzi; Anna ..., Proceedings of the National Academy of Sciences current issue, 2015

Near-infrared fluorescence (NIRF) molecular imaging has been widely applied to monitoring therapy of cancer and other diseases in preclinical studies; however, this technology has not been applied successfully to monitoring therapy for Alzheimer’s disease (AD). Although several NIRF probes for ...

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Functional expression of sodium-glucose transporters in cancer [Medical Sciences]

28-Jul-2015 | Claudio Scafoglio; Bruce A. Hirayama; Vladimir Kepe; Jie Liu; Chiara Ghezzi; Nagichettiar Satyamurthy; Neda A. Moata ..., Proceedings of the National Academy of Sciences current issue, 2015

Glucose is a major metabolic substrate required for cancer cell survival and growth. It is mainly imported into cells by facilitated glucose transporters (GLUTs). Here we demonstrate the importance of another glucose import system, the sodium-dependent glucose transporters (SGLTs), in pancreatic ...

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Massively parallel enzyme kinetics reveals the substrate recognition landscape of the metalloprotease ADAMTS13 [Biochemistry]

28-Jul-2015 | Colin A. Kretz; Manhong Dai; Onuralp Soylemez; Andrew Yee; Karl C. Desch; David Siemieniak; Kärt Tomberg; Fyodor A. ..., Proceedings of the National Academy of Sciences current issue, 2015

Proteases play important roles in many biologic processes and are key mediators of cancer, inflammation, and thrombosis. However, comprehensive and quantitative techniques to define the substrate specificity profile of proteases are lacking. The metalloprotease ADAMTS13 regulates blood ...

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Mutation-induced protein interaction kinetics changes affect apoptotic network dynamic properties and facilitate oncogenesis [Biophysics and Computational Biology]

28-Jul-2015 | Linjie Zhao; Tanlin Sun; Jianfeng Pei; Qi Ouyang, Proceedings of the National Academy of Sciences current issue, 2015

It has been a consensus in cancer research that cancer is a disease caused primarily by genomic alterations, especially somatic mutations. However, the mechanism of mutation-induced oncogenesis is not fully understood. Here, we used the mitochondrial apoptotic pathway as a case study and ...

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Chromosomal directionality of DNA mismatch repair in Escherichia coli [Genetics]

28-Jul-2015 | A. M. Mahedi Hasan; David R. F. Leach, Proceedings of the National Academy of Sciences current issue, 2015

Defects in DNA mismatch repair (MMR) result in elevated mutagenesis and in cancer predisposition. This disease burden arises because MMR is required to correct errors made in the copying of DNA. MMR is bidirectional at the level of DNA strand polarity as it operates equally well in the 5′ to...

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