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402 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

In vivo anticancer activity of rhomboidal Pt(II) metallacycles [Chemistry]

30-Dec-2014 | Ivan V. Grishagin; J. Bryant Pollock; Swati Kushal; Timothy R. Cook; Peter J. Stang; Bogdan Z. Olenyuk, Proceedings of the National Academy of Sciences current issue, 2014

The development of novel antitumor agents that have high efficacy in suppressing tumor growth, have low toxicity to nontumor tissues, and exhibit rapid localization in the targeted tumor sites is an ongoing avenue of research at the interface of chemistry, cancer biology, and pharmacology. ...

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Quantum delocalization of protons in the hydrogen-bond network of an enzyme active site [Chemistry]

30-Dec-2014 | Lu Wang; Stephen D. Fried; Steven G. Boxer; Thomas E. Markland, Proceedings of the National Academy of Sciences current issue, 2014

Enzymes use protein architectures to create highly specialized structural motifs that can greatly enhance the rates of complex chemical transformations. Here, we use experiments, combined with ab initio simulations that exactly include nuclear quantum effects, to show that a triad of strongly ...

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Robert Letsinger: The father of synthetic DNA chemistry [Retrospectives]

23-Dec-2014 | Marvin H. Caruthers, Proceedings of the National Academy of Sciences current issue, 2014

On May 26, 2014, Robert Lewis Letsinger died after a slow, progressive loss of his health. He played bridge with his family on Saturday, slipped into a coma Sunday, and died Monday. Thus ended the life of one of the most remarkable and productive scientists of his generation. All who...

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Preserving ancient artifacts for the next millennia [Chemistry]

16-Dec-2014 | Samuel L. Zelinka, Proceedings of the National Academy of Sciences current issue, 2014

When wood is kept dry, it can remain intact for millennia, as evidenced by numerous artifacts from ancient Egypt (1). However, when wood interacts with water, numerous problems arise that can cause the wood to become permanently damaged or destroyed completely. Wood exhibits swelling on moisture ...

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Multifunctional supramolecular polymer networks as next-generation consolidants for archaeological wood conservation [Chemistry]

16-Dec-2014 | Zarah Walsh; Emma-Rose Janeček; James T. Hodgkinson; Julia Sedlmair; Alexandros Koutsioubas; David R. Spring; Martin ..., Proceedings of the National Academy of Sciences current issue, 2014

The preservation of our cultural heritage is of great importance to future generations. Despite this, significant problems have arisen with the conservation of waterlogged wooden artifacts. Three major issues facing conservators are structural instability on drying, biological degradation, and ...

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Trapping the ATP binding state leads to a detailed understanding of the F1-ATPase mechanism [Chemistry]

16-Dec-2014 | Kwangho Nam; Jingzhi Pu; Martin Karplus, Proceedings of the National Academy of Sciences current issue, 2014

The rotary motor enzyme FoF1-ATP synthase uses the proton-motive force across a membrane to synthesize ATP from ADP and Pi (H2PO4−) under cellular conditions that favor the hydrolysis reaction by a factor of 2 × 105. This remarkable ability to drive a reaction away from equilibrium by harnessing ...

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Energetics of metastudtite and implications for nuclear waste alteration [Chemistry]

16-Dec-2014 | Xiaofeng Guo; Sergey V. Ushakov; Sabrina Labs; Hildegard Curtius; Dirk Bosbach; Alexandra Navrotsky, Proceedings of the National Academy of Sciences current issue, 2014

Metastudtite, (UO2)O2(H2O)2, is one of two known natural peroxide minerals, but little is established about its thermodynamic stability. In this work, its standard enthalpy of formation, −1,779.6 ± 1.9 kJ/mol, was obtained by high temperature oxide melt drop solution calorimetry. Decomposition of ...

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Orientation of aromatic residues in amyloid cores: Structural insights into prion fiber diversity [Chemistry]

02-Dec-2014 | Anna Reymer; Kendra K. Frederick; Sandra Rocha; Tamás Beke-Somfai; Catherine C. Kitts; Susan Lindquist; Bengt Nordén, Proceedings of the National Academy of Sciences current issue, 2014

Structural conversion of one given protein sequence into different amyloid states, resulting in distinct phenotypes, is one of the most intriguing phenomena of protein biology. Despite great efforts the structural origin of prion diversity remains elusive, mainly because amyloids are insoluble ...

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Flexible and conductive MXene films and nanocomposites with high capacitance [Chemistry]

25-Nov-2014 | Zheng Ling; Chang E. Ren; Meng-Qiang Zhao; Jian Yang; James M. Giammarco; Jieshan Qiu; Michel W. Barsoum; Yury Gogotsi, Proceedings of the National Academy of Sciences current issue, 2014

MXenes, a new family of 2D materials, combine hydrophilic surfaces with metallic conductivity. Delamination of MXene produces single-layer nanosheets with thickness of about a nanometer and lateral size of the order of micrometers. The high aspect ratio of delaminated MXene renders it promising ...

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Bispecific antibody generated with sortase and click chemistry has broad antiinfluenza virus activity [Immunology and Inflammation]

25-Nov-2014 | Koen Wagner; Mark J. Kwakkenbos; Yvonne B. Claassen; Kelly Maijoor; Martino Böhne; Koenraad F. van der Sluijs; Marti ..., Proceedings of the National Academy of Sciences current issue, 2014

Bispecific antibodies have therapeutic potential by expanding the functions of conventional antibodies. Many different formats of bispecific antibodies have meanwhile been developed. Most are genetic modifications of the antibody backbone to facilitate incorporation of two different variable ...

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