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422 Newest Publications in proceedings of the national academy of sciences current issue

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Locating landmarks on high-dimensional free energy surfaces [Chemistry]

17-Mar-2015 | Ming Chen; Tang-Qing Yu; Mark E. Tuckerman, Proceedings of the National Academy of Sciences current issue, 2015

Coarse graining of complex systems possessing many degrees of freedom can often be a useful approach for analyzing and understanding key features of these systems in terms of just a few variables. The relevant energy landscape in a coarse-grained description is the free energy surface as a ...

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Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming of Penicillium chrysogenum [Chemistry]

03-Mar-2015 | Kirsty J. McLean; Marcus Hans; Ben Meijrink; Wibo B. van Scheppingen; Aad Vollebregt; Kang Lan Tee; Jan-Metske van d ..., Proceedings of the National Academy of Sciences current issue, 2015

The cholesterol-lowering blockbuster drug pravastatin can be produced by stereoselective hydroxylation of the natural product compactin. We report here the metabolic reprogramming of the antibiotics producer Penicillium chrysogenum toward an industrial pravastatin production process. Following ...

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Correction for Han et al., Quantum dot/antibody conjugates for in vivo cytometric imaging in mice [Correction]

03-Mar-2015 | Proceedings of the National Academy of Sciences current issue, 2015

APPLIED BIOLOGICAL SCIENCES, CHEMISTRY Correction for “Quantum dot/antibody conjugates for in vivo cytometric imaging in mice,” by Hee-Sun Han, Elisabeth Niemeyer, Yuhui Huang, Walid S. Kamoun, John D. Martin, Jayeeta Bhaumik, Yunching Chen, Sylvie Roberge, Jian Cui, Margaret R. Martin, Dai ...

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Profile of Eric Betzig, Stefan Hell, and W. E. Moerner, 2014 Nobel Laureates in Chemistry [Profiles]

03-Mar-2015 | Jennifer Lippincott-Schwartz, Proceedings of the National Academy of Sciences current issue, 2015

Scientists once believed that the laws of physics would prevent them from peering into the structures of the cell. The story of the winners of the 2014 Nobel Prize in Chemistry is about how three imaginative scientists pioneered ways to work around these supposed limits, transforming microscopy ...

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Classification of charge density waves based on their nature [Physics]

24-Feb-2015 | Xuetao Zhu; Yanwei Cao; Jiandi Zhang; E. W. Plummer; Jiandong Guo, Proceedings of the National Academy of Sciences current issue, 2015

The concept of a charge density wave (CDW) permeates much of condensed matter physics and chemistry. CDWs have their origin rooted in the instability of a one-dimensional system described by Peierls. The extension of this concept to reduced dimensional systems has led to the concept of Fermi ...

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Propagation of aggregated p53: Cross-reaction and coaggregation vs. seeding [Chemistry]

24-Feb-2015 | GuoZhen Wang; Alan R. Fersht, Proceedings of the National Academy of Sciences current issue, 2015

Destabilized mutant p53s coaggregate with WT p53, p63, and p73 in cancer cell lines. We found that stoichiometric amounts of aggregation-prone mutants induced only small amounts of WT p53 to coaggregate, and preformed aggregates did not significantly seed the aggregation of bulk protein. ...

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Elucidation of synaptonemal complex organization by super-resolution imaging with isotropic resolution [Chemistry]

17-Feb-2015 | Katharina Schücker; Thorge Holm; Christian Franke; Markus Sauer; Ricardo Benavente, Proceedings of the National Academy of Sciences current issue, 2015

Synaptonemal complexes (SCs) are meiosis-specific multiprotein complexes that are essential for synapsis, recombination, and segregation of homologous chromosomes, but the molecular organization of SCs remains unclear. We used immunofluorescence labeling in combination with super-resolution ...

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Quantum dot/antibody conjugates for in vivo cytometric imaging in mice [Chemistry]

03-Feb-2015 | Hee-Sun Han; Elisabeth Niemeyer; Yuhui Huang; Walid S. Kamoun; John D. Martin; Jayeeta Bhaumik; Yunching Chen; Sylvi ..., Proceedings of the National Academy of Sciences current issue, 2015

Multiplexed, phenotypic, intravital cytometric imaging requires novel fluorophore conjugates that have an appropriate size for long circulation and diffusion and show virtually no nonspecific binding to cells/serum while binding to cells of interest with high specificity. In addition, these ...

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Kinetics of protein-ligand unbinding: Predicting pathways, rates, and rate-limiting steps [Chemistry]

03-Feb-2015 | Pratyush Tiwary; Vittorio Limongelli; Matteo Salvalaglio; Michele Parrinello, Proceedings of the National Academy of Sciences current issue, 2015

The ability to predict the mechanisms and the associated rate constants of protein–ligand unbinding is of great practical importance in drug design. In this work we demonstrate how a recently introduced metadynamics-based approach allows exploration of the unbinding pathways, estimation of the ...

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X-ray crystallographic and EPR spectroscopic analysis of HydG, a maturase in [FeFe]-hydrogenase H-cluster assembly [Chemistry]

03-Feb-2015 | Pedro Dinis; Daniel L. M. Suess; Stephen J. Fox; Jenny E. Harmer; Rebecca C. Driesener; Liliana De La Paz; James R. ..., Proceedings of the National Academy of Sciences current issue, 2015

Hydrogenases use complex metal cofactors to catalyze the reversible formation of hydrogen. In [FeFe]-hydrogenases, the H-cluster cofactor includes a diiron subcluster containing azadithiolate, three CO, and two CN− ligands. During the assembly of the H cluster, the radical S-adenosyl methionine ...

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