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288 Newest Publications in proceedings of the national academy of sciences current issue
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matching the following criteria
Physical and genetic-interaction density reveals functional organization and informs significance cutoffs in genome-wide screens [Genetics]
30-04-2013 | John C. Dittmar; Steven Pierce; Rodney Rothstein; Robert J. D. Reid, Proceedings of the National Academy of Sciences current issue, 2013
Genome-wide experiments often measure quantitative differences between treated and untreated cells to identify affected strains. For these studies, statistical models are typically used to determine significance cutoffs. We developed a method termed “CLIK” (Cutoff Linked to Interaction ...
Nuclear resonance vibrational spectroscopic and computational study of high-valent diiron complexes relevant to enzyme intermediates [Biophysics and Computational Biology]
16-04-2013 | Kiyoung Park; Caleb B. Bell III; Lei V. Liu; Dong Wang; Genqiang Xue; Yeonju Kwak; Shaun D. Wong; Kenneth M. Light; ..., Proceedings of the National Academy of Sciences current issue, 2013
High-valent intermediates of binuclear nonheme iron enzymes are structurally unknown despite their importance for understanding enzyme reactivity. Nuclear resonance vibrational spectroscopy combined with density functional theory calculations has been applied to structurally ...
Microscopic structure of water at elevated pressures and temperatures [Physics]
16-04-2013 | Christoph J. Sahle; Christian Sternemann; Christian Schmidt; Susi Lehtola; Sandro Jahn; Laura Simonelli; Simo Huotar ..., Proceedings of the National Academy of Sciences current issue, 2013
We report on the microscopic structure of water at sub- and supercritical conditions studied using X-ray Raman spectroscopy, ab initio molecular dynamics simulations, and density functional theory. Systematic changes in the X-ray Raman spectra with increasing pressure and temperature are ...
Gene expression-based modeling of human cortical synaptic density [Neuroscience]
16-04-2013 | Manu S. Goyal; Marcus E. Raichle, Proceedings of the National Academy of Sciences current issue, 2013
Postnatal cortical synaptic development is characterized by stages of exuberant growth, pruning, and stabilization during adulthood. How gene expression orchestrates these stages of synaptic development is poorly understood. Here we report that synaptic growth-related gene expression alone ...
Dense colloidal fluids form denser amorphous sediments [Physics]
09-04-2013 | Shir R. Liber; Shai Borohovich; Alexander V. Butenko; Andrew B. Schofield; Eli Sloutskin, Proceedings of the National Academy of Sciences current issue, 2013
We relate, by simple analytical centrifugation experiments, the density of colloidal fluids with the nature of their randomly packed solid sediments. We demonstrate that the most dilute fluids of colloidal hard spheres form loosely packed sediments, where the volume fraction of the particles ...
Strong subunit coordination drives a powerful viral DNA packaging motor [Biochemistry]
09-04-2013 | Benjamin T. Andrews; Carlos Enrique Catalano, Proceedings of the National Academy of Sciences current issue, 2013
Terminase enzymes are viral motors that package DNA into a preformed capsid and are of interest both therapeutically and as potential nano-machines. The enzymes excise a single genome from a concatemeric precursor (genome maturation) and then package the duplex to near-crystalline density ...
In vitro and in vivo delivery of genes and proteins using the bacteriophage T4 DNA packaging machine [Applied Biological Sciences]
09-04-2013 | Pan Tao; Marthandan Mahalingam; Bernard S. Marasa; Zhihong Zhang; Ashok K. Chopra; Venigalla B. Rao, Proceedings of the National Academy of Sciences current issue, 2013
The bacteriophage T4 DNA packaging machine consists of a molecular motor assembled at the portal vertex of an icosahedral head. The ATP-powered motor packages the 56-µm-long, 170-kb viral genome into 120 nm × 86 nm head to near crystalline density. We engineered this machine to deliver genes ...
Formation of the -N(NO)N(NO)- polymer at high pressure and stabilization at ambient conditions [Chemistry]
02-04-2013 | Hai Xiao; Qi An; William A. Goddard III; Wei-Guang Liu; Sergey V. Zybin, Proceedings of the National Academy of Sciences current issue, 2013
A number of exotic structures have been formed through high-pressure chemistry, but applications have been hindered by difficulties in recovering the high-pressure phase to ambient conditions (i.e., one atmosphere and 300 K). Here we use dispersion-corrected density functional theory [PBE-ulg ...
Toward a unified physical model of nucleosome patterns flanking transcription start sites [Physics]
02-04-2013 | Wolfram Möbius; Brendan Osberg; Alexander M. Tsankov; Oliver J. Rando; Ulrich Gerland, Proceedings of the National Academy of Sciences current issue, 2013
Recent genome-wide maps of nucleosome positions in different eukaryotes revealed patterns around transcription start sites featuring a nucleosome-free region flanked by a periodic modulation of the nucleosome density. For Saccharomyces cerevisiae, the average in vivo pattern was previously ...
Toward high-energy-density, high-efficiency, and moderate-temperature chip-scale thermophotovoltaics [Applied Physical Sciences]
02-04-2013 | Walker R. Chan; Peter Bermel; Robert C. N. Pilawa-Podgurski; Christopher H. Marton; Klavs F. Jensen; Jay J. Senkevic ..., Proceedings of the National Academy of Sciences current issue, 2013
The challenging problem of ultra-high-energy-density, high-efficiency, and small-scale portable power generation is addressed here using a distinctive thermophotovoltaic energy conversion mechanism and chip-based system design, which we name the microthermophotovoltaic (μTPV) generator. The ...
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