My watch list
my.chemeurope.com  
Login  

932 Newest Publications in proceedings of the national academy of sciences current issue

rss
matching the following criteria

Cells infected with herpes simplex virus 1 export to uninfected cells exosomes containing STING, viral mRNAs, and microRNAs [Microbiology]

18-11-2014 | Maria Kalamvoki; Te Du; Bernard Roizman, Proceedings of the National Academy of Sciences current issue, 2014

STING (stimulator of IFN genes) activates the IFN-dependent innate immune response to infection on sensing the presence of DNA in cytosol. The quantity of STING accumulating in cultured cells varies; it is relatively high in some cell lines [e.g., HEp-2, human embryonic lung fibroblasts (HEL), ...

more

siRNAs from an X-linked satellite repeat promote X-chromosome recognition in Drosophila melanogaster [Genetics]

18-11-2014 | Debashish U. Menon; Cristian Coarfa; Weimin Xiao; Preethi H. Gunaratne; Victoria H. Meller, Proceedings of the National Academy of Sciences current issue, 2014

Highly differentiated sex chromosomes create a lethal imbalance in gene expression in one sex. To accommodate hemizygosity of the X chromosome in male fruit flies, expression of X-linked genes increases twofold. This is achieved by the male- specific lethal (MSL) complex, which modifies chromatin ...

more

Horizontal transfer beyond genes [Microbiology]

11-11-2014 | Eugene V. Koonin, Proceedings of the National Academy of Sciences current issue, 2014

Horizontal gene transfer (HGT) is a major process in the evolution of bacteria and archaea (1–3) that is thought to be the principal source of functional innovation in microbial evolution (4, 5). The signal of vertical, tree-like evolution is detectable primarily among genes encoding components ...

more

Prevalence of cycling genes and drug targets calls for prospective chronotherapeutics [Systems Biology]

11-11-2014 | Nimish D. Kathale; Andrew C. Liu, Proceedings of the National Academy of Sciences current issue, 2014

There are two main threads in biomedical research: One is to discover how biological systems work, basic science; and the other is to use knowledge obtained from basic research in medicine, translation. The availability of genome sequences has brought an unprecedented opportunity for discovery ...

more

Timing and heterogeneity of mutations associated with drug resistance in metastatic cancers [Applied Mathematics]

11-11-2014 | Ivana Bozic; Martin A. Nowak, Proceedings of the National Academy of Sciences current issue, 2014

Targeted therapies provide an exciting new approach to combat human cancer. The immediate effect is a dramatic reduction in disease burden, but in most cases, the tumor returns as a consequence of resistance. Various mechanisms for the evolution of resistance have been implicated, including ...

more

Activity-dependent PI(3,5)P2 synthesis controls AMPA receptor trafficking during synaptic depression [Neuroscience]

11-11-2014 | Amber J. McCartney; Sergey N. Zolov; Emily J. Kauffman; Yanling Zhang; Bethany S. Strunk; Lois S. Weisman; Michael A ..., Proceedings of the National Academy of Sciences current issue, 2014

Dynamic regulation of phosphoinositide lipids (PIPs) is crucial for diverse cellular functions, and, in neurons, PIPs regulate membrane trafficking events that control synapse function. Neurons are particularly sensitive to the levels of the low abundant PIP, phosphatidylinositol 3,5-bisphosphate ...

more

A circadian gene expression atlas in mammals: Implications for biology and medicine [Systems Biology]

11-11-2014 | Ray Zhang; Nicholas F. Lahens; Heather I. Ballance; Michael E. Hughes; John B. Hogenesch, Proceedings of the National Academy of Sciences current issue, 2014

To characterize the role of the circadian clock in mouse physiology and behavior, we used RNA-seq and DNA arrays to quantify the transcriptomes of 12 mouse organs over time. We found 43% of all protein coding genes showed circadian rhythms in transcription somewhere in the body, largely in an ...

more

Correction for Majithia et al., Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes [Corrections]

11-11-2014 | Proceedings of the National Academy of Sciences current issue, 2014

GENETICS Correction for “Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes,” by Amit R. Majithia, Jason Flannick, Peter Shahinian, Michael Guo, Mark-Anthony Bray, Pierre Fontanillas, Stacey B. Gabriel, GoT2D ...

more

Genomic and transcriptomic analyses of the medicinal fungus Antrodia cinnamomea for its metabolite biosynthesis and sexual development [Genetics]

04-11-2014 | Mei-Yeh Jade Lu; Wen-Lang Fan; Woei-Fuh Wang; Tingchun Chen; Yi-Ching Tang; Fang-Hua Chu; Tun-Tschu Chang; Sheng-Yan ..., Proceedings of the National Academy of Sciences current issue, 2014

Antrodia cinnamomea, a polyporus mushroom of Taiwan, has long been used as a remedy for cancer, hypertension, and hangover, with an annual market of over $100 million (US) in Taiwan. We obtained a 32.15-Mb genome draft containing 9,254 genes. Genome ontology enrichment and pathway analyses shed ...

more

Correction for Martins et al., Host adaptation to viruses relies on few genes with different cross-resistance properties [Corrections]

28-10-2014 | Proceedings of the National Academy of Sciences current issue, 2014

EVOLUTION Correction for “Host adaptation to viruses relies on few genes with different cross-resistance properties,” by Nelson E. Martins, Vítor G. Faria, Viola Nolte, Christian Schlötterer, Luis Teixeira, Élio Sucena, and Sara Magalhães, which appeared in issue 16, April 22, 2014, of Proc Natl ...

more

Page 1 From 94
Subscribe to e-mail updates relating to your search

You will receive via e-mail the latest search results matching your search criteria. This service is free of charge and can be cancelled at any time.

Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE