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1,000 Newest Publications in proceedings of the national academy of sciences current issue

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The genome of cultivated sweet potato contains Agrobacterium T-DNAs with expressed genes: An example of a naturally transgenic food crop [Plant Biology]

05-May-2015 | Tina Kyndt; Dora Quispe; Hong Zhai; Robert Jarret; Marc Ghislain; Qingchang Liu; Godelieve Gheysen; Jan F. Kreuze, Proceedings of the National Academy of Sciences current issue, 2015

Agrobacterium rhizogenes and Agrobacterium tumefaciens are plant pathogenic bacteria capable of transferring DNA fragments [transfer DNA (T-DNA)] bearing functional genes into the host plant genome. This naturally occurring mechanism has been adapted by plant biotechnologists to develop ...

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Olfactory receptor genes expressed in distinct lineages are sequestered in different nuclear compartments [Neuroscience]

05-May-2015 | Kyoung-hye Yoon; Tobias Ragoczy; Zhonghua Lu; Kunio Kondoh; Donghui Kuang; Mark Groudine; Linda B. Buck, Proceedings of the National Academy of Sciences current issue, 2015

The olfactory system translates a vast array of volatile chemicals into diverse odor perceptions and innate behaviors. Odor detection in the mouse nose is mediated by 1,000 different odorant receptors (ORs) and 14 trace amine-associated receptors (TAARs). ORs are used in a combinatorial manner to ...

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Control of bacterial exoelectrogenesis by c-AMP-GMP [Biochemistry]

28-Apr-2015 | James W. Nelson; Narasimhan Sudarsan; Grace E. Phillips; Shira Stav; Christina E. Lünse; Phillip J. McCown; Ronald R ..., Proceedings of the National Academy of Sciences current issue, 2015

Major changes in bacterial physiology including biofilm and spore formation involve signaling by the cyclic dinucleotides c-di-GMP and c-di-AMP. Recently, another second messenger dinucleotide, c-AMP-GMP, was found to control chemotaxis and colonization by Vibrio cholerae. We have identified a ...

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Reply to Wilkinson: Minor role of programmed methylation and demethylation in mammalian development [Biological Sciences]

28-Apr-2015 | Timothy H. Bestor; John R. Edwards; Mathieu Boulard, Proceedings of the National Academy of Sciences current issue, 2015

Wilkinson (1) does not dispute any of our (2) main claims: that CpG-dense promoters are unmethylated in all tissues and CpG-poor promoters are variably methylated and undergo transcription factor-induced demethylation after activation; that global genome demethylation in cells and tissues does ...

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General and condition-specific essential functions of Pseudomonas aeruginosa [Microbiology]

21-Apr-2015 | Samuel A. Lee; Larry A. Gallagher; Metawee Thongdee; Benjamin J. Staudinger; Soyeon Lippman; Pradeep K. Singh; Colin ..., Proceedings of the National Academy of Sciences current issue, 2015

The essential functions of a bacterial pathogen reflect the most basic processes required for its viability and growth, and represent potential therapeutic targets. Most screens for essential genes have assayed a single condition—growth in a rich undefined medium—and thus have not distinguished ...

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Stress sigma factor RpoS degradation and translation are sensitive to the state of central metabolism [Microbiology]

21-Apr-2015 | Aurelia Battesti; Nadim Majdalani; Susan Gottesman, Proceedings of the National Academy of Sciences current issue, 2015

RpoS, the stationary phase/stress sigma factor of Escherichia coli, regulates a large cohort of genes important for the cell to deal with suboptimal conditions. Its level increases quickly in the cell in response to many stresses and returns to low levels when growth resumes. Increased RpoS ...

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Clustering of mammalian Hox genes with other H3K27me3 targets within an active nuclear domain [Developmental Biology]

14-Apr-2015 | Maxence Vieux-Rochas; Pierre J. Fabre; Marion Leleu; Denis Duboule; Daan Noordermeer, Proceedings of the National Academy of Sciences current issue, 2015

Embryogenesis requires the precise activation and repression of many transcriptional regulators. The Polycomb group proteins and the associated H3K27me3 histone mark are essential to maintain the inactive state of many of these genes. Mammalian Hox genes are targets of Polycomb proteins and form ...

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Shapely DNA attracts the right partner [Biophysics and Computational Biology]

14-Apr-2015 | Teresa M. Przytycka; David Levens, Proceedings of the National Academy of Sciences current issue, 2015

All levels of cell activity are coordinated directly or indirectly by transcription factors (TFs). In turn, the functioning of TFs relies on their ability to recognize and bind specific DNA sequences to regulate the expression of specific genes. How exactly this specificity is achieved is still ...

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Juvenile hormone-activated phospholipase C pathway enhances transcriptional activation by the methoprene-tolerant protein [Developmental Biology]

14-Apr-2015 | Pengcheng Liu; Hong-Juan Peng; Jinsong Zhu, Proceedings of the National Academy of Sciences current issue, 2015

Juvenile hormone (JH) is a key regulator of a wide diversity of developmental and physiological events in insects. Although the intracellular JH receptor methoprene-tolerant protein (MET) functions in the nucleus as a transcriptional activator for specific JH-regulated genes, some JH responses ...

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Unraveling the association between mRNA expressions and mutant phenotypes in a genome-wide assessment of mice [Genetics]

14-Apr-2015 | Ben-Yang Liao; Meng-Pin Weng, Proceedings of the National Academy of Sciences current issue, 2015

High-throughput gene expression profiling has revealed substantial leaky and extraneous transcription of eukaryotic genes, challenging the perceptions that transcription is strictly regulated and that changes in transcription have phenotypic consequences. To assess the functional implications of ...

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