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1,105 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

Common BRAF(V600E)-directed pathway mediates widespread epigenetic silencing in colorectal cancer and melanoma [Cell Biology]

02-Feb-2016 | Minggang Fang; Lloyd Hutchinson; April Deng; Michael R. Green, Proceedings of the National Academy of Sciences current issue, 2016

During cancer development, it is well established that many genes, including tumor suppressor genes, are hypermethylated and transcriptionally repressed, a phenomenon referred to as epigenetic silencing. In general, the factors involved in, and the mechanistic basis of, epigenetic silencing ...

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MHC class II super-enhancer increases surface expression of HLA-DR and HLA-DQ and affects cytokine production in autoimmune vitiligo [Immunology and Inflammation]

02-Feb-2016 | Giulio Cavalli; Masahiro Hayashi; Ying Jin; Daniel Yorgov; Stephanie A. Santorico; Cherie Holcomb; Melinda Rastrou; ..., Proceedings of the National Academy of Sciences current issue, 2016

Genetic risk for autoimmunity in HLA genes is most often attributed to structural specificity resulting in presentation of self-antigens. Autoimmune vitiligo is strongly associated with the MHC class II region. Here, we fine-map vitiligo MHC class II genetic risk to three SNPs only 47 bp apart, ...

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Nuclear hormone receptor DHR96 mediates the resistance to xenobiotics but not the increased lifespan of insulin-mutant Drosophila [Genetics]

02-Feb-2016 | Sonita Afschar; Janne M. Toivonen; Julia Marianne Hoffmann; Luke Stephen Tain; Daniela Wieser; Andrew John Finlayson ..., Proceedings of the National Academy of Sciences current issue, 2016

Lifespan of laboratory animals can be increased by genetic, pharmacological, and dietary interventions. Increased expression of genes involved in xenobiotic metabolism, together with resistance to xenobiotics, are frequent correlates of lifespan extension in the nematode worm Caenorhabditis ...

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Testing the kinship theory of intragenomic conflict in honey bees (Apis mellifera) [Genetics]

26-Jan-2016 | David A. Galbraith; Sarah D. Kocher; Tom Glenn; Istvan Albert; Greg J. Hunt; Joan E. Strassmann; David C. Queller; C ..., Proceedings of the National Academy of Sciences current issue, 2016

Sexual reproduction brings genes from two parents (matrigenes and patrigenes) together into one individual. These genes, despite being unrelated, should show nearly perfect cooperation because each gains equally through the production of offspring. However, an individual’s matrigenes and ...

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Discovery of RNA splicing and genes in pieces [Biochemistry]

26-Jan-2016 | Arnold J. Berk, Proceedings of the National Academy of Sciences current issue, 2016

The Problem: Short-Lived Heterogeneous Nuclear RNA During the 1960s and 1970s, there was a major conundrum in eukaryotic molecular biology regarding the synthesis of mRNA in animal cells. Pulse and pulse-chase radio-labeling experiments with tritiated uridine had shown that a large fraction of ...

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Transcriptional profiles of supragranular-enriched genes associate with corticocortical network architecture in the human brain [Neuroscience]

26-Jan-2016 | Fenna M. Krienen; B. T. Thomas Yeo; Tian Ge; Randy L. Buckner; Chet C. Sherwood, Proceedings of the National Academy of Sciences current issue, 2016

The human brain is patterned with disproportionately large, distributed cerebral networks that connect multiple association zones in the frontal, temporal, and parietal lobes. The expansion of the cortical surface, along with the emergence of long-range connectivity networks, may be reflected in ...

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Autoregulatory loop of nuclear corepressor 1 expression controls invasion, tumor growth, and metastasis [Medical Sciences]

19-Jan-2016 | Olaia A. Martínez-Iglesias; Elvira Alonso-Merino; Sara Gómez-Rey; Juan Pedro Velasco-Martín; Rosa Martín Orozco; Enr ..., Proceedings of the National Academy of Sciences current issue, 2016

Nuclear corepressor 1 (NCoR) associates with nuclear receptors and other transcription factors leading to transcriptional repression. We show here that NCoR depletion enhances cancer cell invasion and increases tumor growth and metastatic potential in nude mice. These changes are related to ...

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Cytokine Diedel and a viral homologue suppress the IMD pathway in Drosophila [Immunology and Inflammation]

19-Jan-2016 | Olivier Lamiable; Christine Kellenberger; Cordula Kemp; Laurent Troxler; Nadège Pelte; Michael Boutros; Joao Trindad ..., Proceedings of the National Academy of Sciences current issue, 2016

Viruses are obligatory intracellular parasites that suffer strong evolutionary pressure from the host immune system. Rapidly evolving viral genomes can adapt to this pressure by acquiring genes that counteract host defense mechanisms. For example, many vertebrate DNA viruses have hijacked ...

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SDPR functions as a metastasis suppressor in breast cancer by promoting apoptosis [Cell Biology]

19-Jan-2016 | Sait Ozturk; Panagiotis Papageorgis; Chen Khuan Wong; Arthur W. Lambert; Hamid M. Abdolmaleky; Arunthathi Thiagaling ..., Proceedings of the National Academy of Sciences current issue, 2016

Metastatic dissemination of breast cancer cells represents a significant clinical obstacle to curative therapy. The loss of function of metastasis suppressor genes is a major rate-limiting step in breast cancer progression that prevents the formation of new colonies at distal sites. However, the ...

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Sex-specific silencing of X-linked genes by Xist RNA [Genetics]

19-Jan-2016 | Srimonta Gayen; Emily Maclary; Michael Hinten; Sundeep Kalantry, Proceedings of the National Academy of Sciences current issue, 2016

X-inactive specific transcript (Xist) long noncoding RNA (lncRNA) is thought to catalyze silencing of X-linked genes in cis during X-chromosome inactivation, which equalizes X-linked gene dosage between male and female mammals. To test the impact of Xist RNA on X-linked gene silencing, we ...

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