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1,132 Newest Publications in proceedings of the national academy of sciences current issue

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Immuno-Navigator, a batch-corrected coexpression database, reveals cell type-specific gene networks in the immune system [Immunology and Inflammation]

26-Apr-2016 | Alexis Vandenbon; Viet H. Dinh; Norihisa Mikami; Yohko Kitagawa; Shunsuke Teraguchi; Naganari Ohkura; Shimon Sakaguchi, Proceedings of the National Academy of Sciences current issue, 2016

High-throughput gene expression data are one of the primary resources for exploring complex intracellular dynamics in modern biology. The integration of large amounts of public data may allow us to examine general dynamical relationships between regulators and target genes. However, obstacles for ...

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Insight into GATA1 transcriptional activity through interrogation of cis elements disrupted in human erythroid disorders [Genetics]

19-Apr-2016 | Aoi Wakabayashi; Jacob C. Ulirsch; Leif S. Ludwig; Claudia Fiorini; Makiko Yasuda; Avik Choudhuri; Patrick McDonel; ..., Proceedings of the National Academy of Sciences current issue, 2016

Whole-exome sequencing has been incredibly successful in identifying causal genetic variants and has revealed a number of novel genes associated with blood and other diseases. One limitation of this approach is that it overlooks mutations in noncoding regulatory elements. Furthermore, the ...

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Oligonucleotide-directed mutagenesis screen to identify pathogenic Lynch syndrome-associated MSH2 DNA mismatch repair gene variants [Genetics]

12-Apr-2016 | Hellen Houlleberghs; Marleen Dekker; Hildo Lantermans; Roos Kleinendorst; Hendrikus Jan Dubbink; Robert M. W. Hofstr ..., Proceedings of the National Academy of Sciences current issue, 2016

Single-stranded DNA oligonucleotides can achieve targeted base-pair substitution with modest efficiency but high precision. We show that “oligo targeting” can be used effectively to study missense mutations in DNA mismatch repair (MMR) genes. Inherited inactivating mutations in DNA MMR genes are ...

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Horizontally acquired genes in early-diverging pathogenic fungi enable the use of host nucleosides and nucleotides [Evolution]

12-Apr-2016 | William G. Alexander; Jennifer H. Wisecaver; Antonis Rokas; Chris Todd Hittinger, Proceedings of the National Academy of Sciences current issue, 2016

Horizontal gene transfer (HGT) among bacteria, archaea, and viruses is widespread, but the extent of transfers from these lineages into eukaryotic organisms is contentious. Here we systematically identify hundreds of genes that were likely acquired horizontally from a variety of sources by the ...

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Combgap contributes to recruitment of Polycomb group proteins in Drosophila [Developmental Biology]

05-Apr-2016 | Payal Ray; Sandip De; Apratim Mitra; Karel Bezstarosti; Jeroen A. A. Demmers; Karl Pfeifer; Judith A. Kassis, Proceedings of the National Academy of Sciences current issue, 2016

Polycomb group (PcG) proteins are responsible for maintaining the silenced transcriptional state of many developmentally regulated genes. PcG proteins are organized into multiprotein complexes that are recruited to DNA via cis-acting elements known as “Polycomb response elements” (PREs). In ...

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Small genome of the fungus Escovopsis weberi, a specialized disease agent of ant agriculture [Evolution]

29-Mar-2016 | Tom J. B. de Man; Jason E. Stajich; Christian P. Kubicek; Clotilde Teiling; Komal Chenthamara; Lea Atanasova; Irina ..., Proceedings of the National Academy of Sciences current issue, 2016

Many microorganisms with specialized lifestyles have reduced genomes. This is best understood in beneficial bacterial symbioses, where partner fidelity facilitates loss of genes necessary for living independently. Specialized microbial pathogens may also exhibit gene loss relative to generalists. ...

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LSD1 modulates stress-evoked transcription of immediate early genes and emotional behavior [Neuroscience]

29-Mar-2016 | Francesco Rusconi; Barbara Grillo; Luisa Ponzoni; Silvia Bassani; Emanuela Toffolo; Leda Paganini; Alessandra Mallei ..., Proceedings of the National Academy of Sciences current issue, 2016

Behavioral changes in response to stressful stimuli can be controlled via adaptive epigenetic changes in neuronal gene expression. Here we indicate a role for the transcriptional corepressor Lysine-Specific Demethylase 1 (LSD1) and its dominant-negative splicing isoform neuroLSD1, in the ...

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Protein networks identify novel symbiogenetic genes resulting from plastid endosymbiosis [Evolution]

29-Mar-2016 | Raphaël Méheust; Ehud Zelzion; Debashish Bhattacharya; Philippe Lopez; Eric Bapteste, Proceedings of the National Academy of Sciences current issue, 2016

The integration of foreign genetic information is central to the evolution of eukaryotes, as has been demonstrated for the origin of the Calvin cycle and of the heme and carotenoid biosynthesis pathways in algae and plants. For photosynthetic lineages, this coordination involved three genomes of ...

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Topologically associated domains enriched for lineage-specific genes reveal expression-dependent nuclear topologies during myogenesis [Cell Biology]

22-Mar-2016 | Daniel S. Neems; Arturo G. Garza-Gongora; Erica D. Smith; Steven T. Kosak, Proceedings of the National Academy of Sciences current issue, 2016

The linear distribution of genes across chromosomes and the spatial localization of genes within the nucleus are related to their transcriptional regulation. The mechanistic consequences of linear gene order, and how it may relate to the functional output of genome organization, remain to be ...

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Reply to Liu and Jiang: Maintenance of postreproductive cognitive capacity by inclusive fitness [Social Sciences]

22-Mar-2016 | Stevan A. Springer; Flavio Schwarz; Tasha K. Altheide; Nissi M. Varki; Ajit Varki; Pascal Gagneux, Proceedings of the National Academy of Sciences current issue, 2016

Our paper examines genes influencing cognitive decline in postreproductive humans, which arises from neurodegenerative and cardiovascular disease (1). Among these polymorphic genes, we found many protective alleles that are derived from and are unique to the human lineage. Liu and Jiang (2) add ...

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