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920 Newest Publications in proceedings of the national academy of sciences current issue

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A receptor-like protein mediates the response to pectin modification by activating brassinosteroid signaling [Plant Biology]

21-10-2014 | Sebastian Wolf; Dieuwertje van der Does; Friederike Ladwig; Carsten Sticht; Andreas Kolbeck; Ann-Kathrin Schürholz; ..., Proceedings of the National Academy of Sciences current issue, 2014

The brassinosteroid (BR) signaling module is a central regulator of plant morphogenesis, as indicated by the large number of BR-responsive cell wall-related genes and the severe growth defects of BR mutants. Despite a detailed knowledge of the signaling components, the logic of this ...

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Exome sequencing identifies FANCM as a susceptibility gene for triple-negative breast cancer [Genetics]

21-10-2014 | Johanna I. Kiiski; Liisa M. Pelttari; Sofia Khan; Edda S. Freysteinsdottir; Inga Reynisdottir; Steven N. Hart; Herme ..., Proceedings of the National Academy of Sciences current issue, 2014

Inherited predisposition to breast cancer is known to be caused by loss-of-function mutations in BRCA1, BRCA2, PALB2, CHEK2, and other genes involved in DNA repair. However, most families severely affected by breast cancer do not harbor mutations in any of these genes. In Finland, founder ...

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CHD8 regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors [Genetics]

21-10-2014 | Aarathi Sugathan; Marta Biagioli; Christelle Golzio; Serkan Erdin; Ian Blumenthal; Poornima Manavalan; Ashok Ragaven ..., Proceedings of the National Academy of Sciences current issue, 2014

Truncating mutations of chromodomain helicase DNA-binding protein 8 (CHD8), and of many other genes with diverse functions, are strong-effect risk factors for autism spectrum disorder (ASD), suggesting multiple mechanisms of pathogenesis. We explored the transcriptional networks that CHD8 ...

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KAISO, a critical regulator of p53-mediated transcription of CDKN1A and apoptotic genes [Biochemistry]

21-10-2014 | Dong-In Koh; Dohyun Han; Hoon Ryu; Won-Il Choi; Bu-Nam Jeon; Min-Kyeong Kim; Youngsoo Kim; Jin Young Kim; Lee Parry; ..., Proceedings of the National Academy of Sciences current issue, 2014

An unresolved issue in genotoxic stress response is identification of induced regulatory proteins and how these activate tumor suppressor p53 to determine appropriate cell responses. Transcription factor KAISO was previously described to repress transcription following binding to methylated DNA. ...

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Role for LSM genes in the regulation of circadian rhythms [Genetics]

21-10-2014 | Soledad Perez-Santángelo; Estefanía Mancini; Lauren J. Francey; Ruben Gustavo Schlaen; Ariel Chernomoretz; John B. H ..., Proceedings of the National Academy of Sciences current issue, 2014

Growing evidence suggests that core spliceosomal components differentially affect RNA processing of specific genes; however, whether changes in the levels or activities of these factors control specific signaling pathways is largely unknown. Here we show that some SM-like (LSM) genes, which ...

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Nitrate foraging by Arabidopsis roots is mediated by the transcription factor TCP20 through the systemic signaling pathway [Plant Biology]

21-10-2014 | Peizhu Guan; Rongchen Wang; Philippe Nacry; Ghislain Breton; Steve A. Kay; Jose L. Pruneda-Paz; Ariea Davani; Nigel ..., Proceedings of the National Academy of Sciences current issue, 2014

To compete for nutrients in diverse soil microenvironments, plants proliferate lateral roots preferentially in nutrient-rich zones. For nitrate, root foraging involves local and systemic signaling; however, little is known about the genes that function in the systemic signaling pathway. By using ...

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Retroviral envelope syncytin capture in an ancestrally diverged mammalian clade for placentation in the primitive Afrotherian tenrecs [Microbiology]

14-10-2014 | Guillaume Cornelis; Cécile Vernochet; Sébastien Malicorne; Sylvie Souquere; Athanasia C. Tzika; Steven M. Goodman; F ..., Proceedings of the National Academy of Sciences current issue, 2014

Syncytins are fusogenic envelope (env) genes of retroviral origin that have been captured for a function in placentation. Syncytins have been identified in Euarchontoglires (primates, rodents, Leporidae) and Laurasiatheria (Carnivora, ruminants) placental mammals. Here, we searched for similar ...

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Rice SPX1 and SPX2 inhibit phosphate starvation responses through interacting with PHR2 in a phosphate-dependent manner [Plant Biology]

14-10-2014 | Zhiye Wang; Wenyuan Ruan; Jing Shi; Li Zhang; Dan Xiang; Chao Yang; Changying Li; Zhongchang Wu; Yu Liu; Yanan Yu; H ..., Proceedings of the National Academy of Sciences current issue, 2014

In plants, sensing the levels of external and internal nutrients is essential for reprogramming the transcriptome and adapting to the fluctuating environment. Phosphate (Pi) is a key plant nutrient, and a large proportion of Pi starvation-responsive genes are under the control of PHOSPHATE ...

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Genomic donor cassette sharing during VLRA and VLRC assembly in jawless vertebrates [Immunology and Inflammation]

14-10-2014 | Sabyasachi Das; Jianxu Li; Stephen J. Holland; Lakshminarayan M. Iyer; Masayuki Hirano; Michael Schorpp; L. Aravind; ..., Proceedings of the National Academy of Sciences current issue, 2014

Lampreys possess two T-like lymphocyte lineages that express either variable lymphocyte receptor (VLR) A or VLRC antigen receptors. VLRA+ and VLRC+ lymphocytes share many similarities with the two principal T-cell lineages of jawed vertebrates expressing the αβ and γδ T-cell receptors (TCRs). ...

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Precisely modulated pathogenicity island interference with late phage gene transcription [Microbiology]

07-10-2014 | Geeta Ram; John Chen; Hope F. Ross; Richard P. Novick, Proceedings of the National Academy of Sciences current issue, 2014

Having gone to great evolutionary lengths to develop resistance to bacteriophages, bacteria have come up with resistance mechanisms directed at every aspect of the bacteriophage life cycle. Most genes involved in phage resistance are carried by plasmids and other mobile genetic elements, ...

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