My watch list
my.chemeurope.com  
Login  

963 Newest Publications in proceedings of the national academy of sciences current issue

rss
matching the following criteria

The SWI/SNF chromatin remodeling complex regulates germinal center formation by repressing Blimp-1 expression [Immunology and Inflammation]

17-Feb-2015 | Jinwook Choi; Shin Jeon; Seungjin Choi; Kyungsoo Park; Rho Hyun Seong, Proceedings of the National Academy of Sciences current issue, 2015

Germinal center (GC) reaction is crucial in adaptive immune responses. The formation of GC is coordinated by the expression of specific genes including Blimp-1 and Bcl-6. Although gene expression is critically influenced by the status of chromatin structure, little is known about the role of ...

more

Quorum sensing and policing of Pseudomonas aeruginosa social cheaters [Microbiology]

17-Feb-2015 | Meizhen Wang; Amy L. Schaefer; Ajai A. Dandekar; E. Peter Greenberg, Proceedings of the National Academy of Sciences current issue, 2015

The bacterium Pseudomonas aeruginosa is an opportunistic human pathogen that uses a quorum sensing signal cascade to activate expression of dozens of genes when sufficient population densities have been reached. Quorum sensing controls production of several key virulence factors, including ...

more

Haploinsufficiency screen highlights two distinct groups of ribosomal protein genes essential for embryonic stem cell fate [Genetics]

17-Feb-2015 | Simon Fortier; Tara MacRae; Mélanie Bilodeau; Tobias Sargeant; Guy Sauvageau, Proceedings of the National Academy of Sciences current issue, 2015

In a functional genomics screen of mouse embryonic stem cells (ESCs) with nested hemizygous chromosomal deletions, we reveal that ribosomal protein (RP) genes are the most significant haploinsufficient determinants for embryoid body (EB) formation. Hemizygocity for three RP genes (Rps5, Rps14, or ...

more

Bacterial proteins pinpoint a single eukaryotic root [Evolution]

17-Feb-2015 | Romain Derelle; Guifré Torruella; Vladimír Klimeš; Henner Brinkmann; Eunsoo Kim; Čestmír Vlček; B. Franz Lang; Marek ..., Proceedings of the National Academy of Sciences current issue, 2015

The large phylogenetic distance separating eukaryotic genes and their archaeal orthologs has prevented identification of the position of the eukaryotic root in phylogenomic studies. Recently, an innovative approach has been proposed to circumvent this issue: the use as phylogenetic markers of ...

more

Profile of Alberto Kornblihtt [Profiles]

17-Feb-2015 | Jennifer Viegas, Proceedings of the National Academy of Sciences current issue, 2015

Molecular biologist Alberto Kornblihtt is proud to work within a tightly knit group of Buenos Aires-based researchers who are studying ribonucleic acids. Kornblihtt and his team investigate the regulation of alternative RNA splicing, a process that affects nearly 90% of human genes. Kornblihtt, ...

more

Galactose metabolic genes in yeast respond to a ratio of galactose and glucose [Systems Biology]

03-Feb-2015 | Renan Escalante-Chong; Yonatan Savir; Sean M. Carroll; John B. Ingraham; Jue Wang; Christopher J. Marx; Michael Springer, Proceedings of the National Academy of Sciences current issue, 2015

Natural environments are filled with multiple, often competing, signals. In contrast, biological systems are often studied in “well-controlled” environments where only a single input is varied, potentially missing important interactions between signals. Catabolite repression of galactose by ...

more

Jagged-Delta asymmetry in Notch signaling can give rise to a Sender/Receiver hybrid phenotype [Physics]

03-Feb-2015 | Marcelo Boareto; Mohit Kumar Jolly; Mingyang Lu; José N. Onuchic; Cecilia Clementi; Eshel Ben-Jacob, Proceedings of the National Academy of Sciences current issue, 2015

Notch signaling pathway mediates cell-fate determination during embryonic development, wound healing, and tumorigenesis. This pathway is activated when the ligand Delta or the ligand Jagged of one cell interacts with the Notch receptor of its neighboring cell, releasing the Notch Intracellular ...

more

MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells [Cell Biology]

03-Feb-2015 | Diego Ploper; Vincent F. Taelman; Lidia Robert; Brian S. Perez; Björn Titz; Hsiao-Wang Chen; Thomas G. Graeber; Erik ..., Proceedings of the National Academy of Sciences current issue, 2015

Canonical Wnt signaling plays an important role in development and disease, regulating transcription of target genes and stabilizing many proteins phosphorylated by glycogen synthase kinase 3 (GSK3). We observed that the MiT family of transcription factors, which includes the melanoma oncogene ...

more

Spata6 is required for normal assembly of the sperm connecting piece and tight head-tail conȷunction [Developmental Biology]

03-Feb-2015 | Shuiqiao Yuan; Clifford J. Stratton; Jianqiang Bao; Huili Zheng; Bhupal P. Bhetwal; Ryuzo Yanagimachi; Wei Yan, Proceedings of the National Academy of Sciences current issue, 2015

“Pinhead sperm,” or “acephalic sperm,” a type of human teratozoospermia, refers to the condition in which ejaculate contains mostly sperm flagella without heads. Family clustering and homogeneity of this syndrome suggests a genetic basis, but the causative genes remain largely unknown. Here we ...

more

Higd1a is a positive regulator of cytochrome c oxidase [Medical Sciences]

03-Feb-2015 | Takaharu Hayashi; Yoshihiro Asano; Yasunori Shintani; Hiroshi Aoyama; Hidetaka Kioka; Osamu Tsukamoto; Masahide Hiki ..., Proceedings of the National Academy of Sciences current issue, 2015

Cytochrome c oxidase (CcO) is the only enzyme that uses oxygen to produce a proton gradient for ATP production during mitochondrial oxidative phosphorylation. Although CcO activity increases in response to hypoxia, the underlying regulatory mechanism remains elusive. By screening for ...

more

Page 1 From 97
Subscribe to e-mail updates relating to your search

You will receive via e-mail the latest search results matching your search criteria. This service is free of charge and can be cancelled at any time.

Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE