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977 Newest Publications in proceedings of the national academy of sciences current issue

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Extraordinary diversity of visual opsin genes in dragonflies [Evolution]

17-Mar-2015 | Ryo Futahashi; Ryouka Kawahara-Miki; Michiyo Kinoshita; Kazutoshi Yoshitake; Shunsuke Yajima; Kentaro Arikawa; Takem ..., Proceedings of the National Academy of Sciences current issue, 2015

Dragonflies are colorful and large-eyed animals strongly dependent on color vision. Here we report an extraordinary large number of opsin genes in dragonflies and their characteristic spatiotemporal expression patterns. Exhaustive transcriptomic and genomic surveys of three dragonflies of the ...

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Rare variants in neuronal excitability genes influence risk for bipolar disorder [Systems Biology]

17-Mar-2015 | Seth A. Ament; Szabolcs Szelinger; Gustavo Glusman; Justin Ashworth; Liping Hou; Nirmala Akula; Tatyana Shekhtman; J ..., Proceedings of the National Academy of Sciences current issue, 2015

We sequenced the genomes of 200 individuals from 41 families multiply affected with bipolar disorder (BD) to identify contributions of rare variants to genetic risk. We initially focused on 3,087 candidate genes with known synaptic functions or prior evidence from genome-wide association studies. ...

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Steric clashes with bound OMP peptides activate the DegS stress-response protease [Biochemistry]

17-Mar-2015 | Anna K. de Regt; Tania A. Baker; Robert T. Sauer, Proceedings of the National Academy of Sciences current issue, 2015

Escherichia coli senses envelope stress using a signaling cascade initiated when DegS cleaves a transmembrane inhibitor of a transcriptional activator for response genes. Each subunit of the DegS trimer contains a protease domain and a PDZ domain. During stress, unassembled outer-membrane ...

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Thioredoxin, a master regulator of the tricarboxylic acid cycle in plant mitochondria [Plant Biology]

17-Mar-2015 | Danilo M. Daloso; Karolin Müller; Toshihiro Obata; Alexandra Florian; Takayuki Tohge; Alexandra Bottcher; Christophe ..., Proceedings of the National Academy of Sciences current issue, 2015

Plant mitochondria have a fully operational tricarboxylic acid (TCA) cycle that plays a central role in generating ATP and providing carbon skeletons for a range of biosynthetic processes in both heterotrophic and photosynthetic tissues. The cycle enzyme-encoding genes have been well ...

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Mutations in early follicular lymphoma progenitors are associated with suppressed antigen presentation [Genetics]

10-Mar-2015 | Michael R. Green; Shingo Kihira; Chih Long Liu; Ramesh V. Nair; Raheleh Salari; Andrew J. Gentles; Jonathan Irish; H ..., Proceedings of the National Academy of Sciences current issue, 2015

Follicular lymphoma (FL) is incurable with conventional therapies and has a clinical course typified by multiple relapses after therapy. These tumors are genetically characterized by B-cell leukemia/lymphoma 2 (BCL2) translocation and mutation of genes involved in chromatin modification. By ...

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Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity [Medical Sciences]

10-Mar-2015 | Matteo Pasetto; Antonella Antignani; Pinar Ormanoglu; Eugen Buehler; Rajarshi Guha; Ira Pastan; Scott E. Martin; Dav ..., Proceedings of the National Academy of Sciences current issue, 2015

Immunotoxins (antibody–toxin fusion proteins) target surface antigens on cancer cells and kill these cells via toxin-mediated inhibition of protein synthesis. To identify genes controlling this process, an RNAi whole-genome screen (∼22,000 genes at three siRNAs per gene) was conducted via ...

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Mutant IDH is sufficient to initiate enchondromatosis in mice [Medical Sciences]

03-Mar-2015 | Makoto Hirata; Masato Sasaki; Rob A. Cairns; Satoshi Inoue; Vijitha Puviindran; Wanda Y. Li; Bryan E. Snow; Lisa D. ..., Proceedings of the National Academy of Sciences current issue, 2015

Enchondromas are benign cartilage tumors and precursors to malignant chondrosarcomas. Somatic mutations in the isocitrate dehydrogenase genes (IDH1 and IDH2) are present in the majority of these tumor types. How these mutations cause enchondromas is unclear. Here, we identified the spectrum of ...

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Automated analysis of high-throughput B-cell sequencing data reveals a high frequency of novel immunoglobulin V gene segment alleles [Immunology and Inflammation]

24-Feb-2015 | Daniel Gadala-Maria; Gur Yaari; Mohamed Uduman; Steven H. Kleinstein, Proceedings of the National Academy of Sciences current issue, 2015

Individual variation in germline and expressed B-cell immunoglobulin (Ig) repertoires has been associated with aging, disease susceptibility, and differential response to infection and vaccination. Repertoire properties can now be studied at large-scale through next-generation sequencing of ...

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Autism-associated mutation inhibits protein kinase C-mediated neuroligin-4X enhancement of excitatory synapses [Neuroscience]

24-Feb-2015 | Michael A. Bemben; Quynh-Anh Nguyen; Tongguang Wang; Yan Li; Roger A. Nicoll; Katherine W. Roche, Proceedings of the National Academy of Sciences current issue, 2015

Autism spectrum disorders (ASDs) comprise a highly heritable, multifarious group of neurodevelopmental disorders, which are characterized by repetitive behaviors and impairments in social interactions. Point mutations have been identified in X-linked Neuroligin (NLGN) 3 and 4X genes in patients ...

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The SWI/SNF chromatin remodeling complex regulates germinal center formation by repressing Blimp-1 expression [Immunology and Inflammation]

17-Feb-2015 | Jinwook Choi; Shin Jeon; Seungjin Choi; Kyungsoo Park; Rho Hyun Seong, Proceedings of the National Academy of Sciences current issue, 2015

Germinal center (GC) reaction is crucial in adaptive immune responses. The formation of GC is coordinated by the expression of specific genes including Blimp-1 and Bcl-6. Although gene expression is critically influenced by the status of chromatin structure, little is known about the role of ...

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