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886 Newest Publications in proceedings of the national academy of sciences current issue

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Integration of responses within and across Arabidopsis natural accessions uncovers loci controlling root systems architecture [Plant Biology]

10-09-2013 | Ulises Rosas; Angelica Cibrian-Jaramillo; Daniela Ristova; Joshua A. Banta; Miriam L. Gifford; Angela Huihui Fan; Ro ..., Proceedings of the National Academy of Sciences current issue, 2013

Phenotypic plasticity is presumed to be involved in adaptive change toward species diversification. We thus examined how candidate genes underlying natural variation across populations might also mediate plasticity within an individual. Our implementation of an integrative “plasticity space” ...

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Protrudin binds atlastins and endoplasmic reticulum-shaping proteins and regulates network formation [Cell Biology]

10-09-2013 | Jaerak Chang; Seongju Lee; Craig Blackstone, Proceedings of the National Academy of Sciences current issue, 2013

Hereditary spastic paraplegias are inherited neurological disorders characterized by progressive lower-limb spasticity and weakness. Although more than 50 genetic loci are known [spastic gait (SPG)1 to -57], over half of hereditary spastic paraplegia cases are caused by pathogenic mutations in ...

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Glucocorticoid receptor represses proinflammatory genes at distinct steps of the transcription cycle [Biochemistry]

03-09-2013 | Rebecca Gupte; Ginger W. Muse; Yurii Chinenov; Karen Adelman; Inez Rogatsky, Proceedings of the National Academy of Sciences current issue, 2013

Widespread anti-inflammatory actions of glucocorticoid hormones are mediated by the glucocorticoid receptor (GR), a ligand-dependent transcription factor of the nuclear receptor superfamily. In conjunction with its corepressor GR-interacting protein-1 (GRIP1), GR tethers to the DNA-bound ...

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Neutralization of terminal differentiation in gliomagenesis [Cell Biology]

03-09-2013 | Jian Hu; Allen L. Ho; Liang Yuan; Baoli Hu; Sujun Hua; Soyoon Sarah Hwang; Jianhua Zhang; Tianyi Hu; Hongwu Zheng; B ..., Proceedings of the National Academy of Sciences current issue, 2013

An immature state of cellular differentiation—characterized by stem cell–like tendencies and impaired differentiation—is a hallmark of cancer. Using glioblastoma multiforme (GBM) as a model system, we sought to determine whether molecular determinants that drive cells toward terminal ...

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Tandem oleosin genes in a cluster acquired in Brassicaceae created tapetosomes and conferred additive benefit of pollen vigor [Plant Biology]

27-08-2013 | Chien Yu Huang; Pei-Ying Chen; Ming-Der Huang; Chih-Hua Tsou; Wann-Neng Jane; Anthony H. C. Huang, Proceedings of the National Academy of Sciences current issue, 2013

During evolution, genomes expanded via whole-genome, segmental, tandem, and individual-gene duplications, and the emerged redundant paralogs would be eliminated or retained owing to selective neutrality or adaptive benefit and further functional divergence. Here we show that tandem paralogs can ...

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Germ-line variant of human NTH1 DNA glycosylase induces genomic instability and cellular transformation [Genetics]

27-08-2013 | Heather A. Galick; Scott Kathe; Minmin Liu; Susan Robey-Bond; Dawit Kidane; Susan S. Wallace; Joann B. Sweasy, Proceedings of the National Academy of Sciences current issue, 2013

Base excision repair (BER) removes at least 20,000 DNA lesions per human cell per day and is critical for the maintenance of genomic stability. We hypothesize that aberrant BER, resulting from mutations in BER genes, can lead to genomic instability and cancer. The first step in BER is catalyzed ...

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Creating memories of transcription [Systems Biology]

20-08-2013 | Ann L. Kirchmaier, Proceedings of the National Academy of Sciences current issue, 2013

Two genetically identical cells grown under the same conditions can exhibit stochastic fluctuations in gene expression. Such cell-to-cell variation in expression of key genes is hypothesized to help drive developmental fate decisions and cell specialization during differentiation. However, to ...

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A high-throughput screen for quorum-sensing inhibitors that target acyl-homoserine lactone synthases [Biochemistry]

20-08-2013 | Quin H. Christensen; Tyler L. Grove; Squire J. Booker; E. Peter Greenberg, Proceedings of the National Academy of Sciences current issue, 2013

Many Proteobacteria use N-acyl-homoserine lactone (acyl-HSL) quorum sensing to control specific genes. Acyl-HSL synthesis requires unique enzymes that use S-adenosyl methionine as an acyl acceptor and amino acid donor. We developed and executed an enzyme-coupled high-throughput cell-free screen ...

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Mod5 protein binds to tRNA gene complexes and affects local transcriptional silencing [Biochemistry]

13-08-2013 | Matthew Pratt-Hyatt; Dave A. Pai; Rebecca A. Haeusler; Glenn G. Wozniak; Paul D. Good; Erin L. Miller; Ian X. McLeod ..., Proceedings of the National Academy of Sciences current issue, 2013

The tRNA gene-mediated (tgm) silencing of RNA polymerase II promoters is dependent on subnuclear clustering of the tRNA genes, but genetic analysis shows that the silencing requires additional mechanisms. We have identified proteins that bind tRNA gene transcription complexes and are required for ...

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Spherical nucleic acids: A whole new ball game [News Feature]

13-08-2013 | Sarah C. P. Williams, Proceedings of the National Academy of Sciences current issue, 2013

Spherical nucleic acids built from multiple strands of DNA dangling from a common center. This configuration drastically changes DNA’s physical and chemical properties. Spherical nucleic acids are revolutionizing drug delivery, gene therapy, and diagnostics. As the molecule that carries our genes ...

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