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940 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome [Medical Sciences]

09-12-2014 | Simin Lu; Kohsuke Kanekura; Takashi Hara; Jana Mahadevan; Larry D. Spears; Christine M. Oslowski; Rita Martinez; May ..., Proceedings of the National Academy of Sciences current issue, 2014

Wolfram syndrome is a genetic disorder characterized by diabetes and neurodegeneration and considered as an endoplasmic reticulum (ER) disease. Despite the underlying importance of ER dysfunction in Wolfram syndrome and the identification of two causative genes, Wolfram syndrome 1 (WFS1) and ...

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Deficiencies in tRNA synthetase editing activity cause cardioproteinopathy [Genetics]

09-12-2014 | Ye Liu; Jakob S. Satz; My-Nuong Vo; Leslie A. Nangle; Paul Schimmel; Susan L. Ackerman, Proceedings of the National Academy of Sciences current issue, 2014

Misfolded proteins are an emerging hallmark of cardiac diseases. Although some misfolded proteins, such as desmin, are associated with mutations in the genes encoding these disease-associated proteins, little is known regarding more general mechanisms that contribute to the generation of ...

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Wnts produced by Osterix-expressing osteolineage cells regulate their proliferation and differentiation [Developmental Biology]

09-12-2014 | Si Hui Tan; Kshemendra Senarath-Yapa; Michael T. Chung; Michael T. Longaker; Joy Y. Wu; Roeland Nusse, Proceedings of the National Academy of Sciences current issue, 2014

Wnt signaling is a critical regulator of bone development, but the identity and role of the Wnt-producing cells are still unclear. We addressed these questions through in situ hybridization, lineage tracing, and genetic experiments. First, we surveyed the expression of all 19 Wnt genes and Wnt ...

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Topoisomerase 1 inhibition reversibly impairs synaptic function [Neuroscience]

02-12-2014 | Angela M. Mabb; Paul H. M. Kullmann; Margaret A. Twomey; Jayalakshmi Miriyala; Benjamin D. Philpot; Mark J. Zylka, Proceedings of the National Academy of Sciences current issue, 2014

Topotecan is a topoisomerase 1 (TOP1) inhibitor that is used to treat various forms of cancer. We recently found that topotecan reduces the expression of multiple long genes, including many neuronal genes linked to synapses and autism. However, whether topotecan alters synaptic protein levels and ...

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Neural precursor-specific expression of multiple Drosophila genes is driven by dual enhancer modules with overlapping function [Developmental Biology]

02-12-2014 | Steven W. Miller; Mark Rebeiz; Jenny E. Atanasov; James W. Posakony, Proceedings of the National Academy of Sciences current issue, 2014

Transcriptional cis-regulatory modules (CRMs), or enhancers, are responsible for directing gene expression in specific territories and cell types during development. In some instances, the same gene may be served by two or more enhancers with similar specificities. Here we show that the ...

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Comparative analysis of the domestic cat genome reveals genetic signatures underlying feline biology and domestication [Genetics]

02-12-2014 | Michael J. Montague; Gang Li; Barbara Gandolfi; Razib Khan; Bronwen L. Aken; Steven M. J. Searle; Patrick Minx; LaDe ..., Proceedings of the National Academy of Sciences current issue, 2014

Little is known about the genetic changes that distinguish domestic cat populations from their wild progenitors. Here we describe a high-quality domestic cat reference genome assembly and comparative inferences made with other cat breeds, wildcats, and other mammals. Based upon these comparisons, ...

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Analysis of clock-regulated genes in Neurospora reveals widespread posttranscriptional control of metabolic potential [Cell Biology]

02-12-2014 | Jennifer M. Hurley; Arko Dasgupta; Jillian M. Emerson; Xiaoying Zhou; Carol S. Ringelberg; Nicole Knabe; Anna M. Lip ..., Proceedings of the National Academy of Sciences current issue, 2014

Neurospora crassa has been for decades a principal model for filamentous fungal genetics and physiology as well as for understanding the mechanism of circadian clocks. Eukaryotic fungal and animal clocks comprise transcription-translation–based feedback loops that control rhythmic transcription ...

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Specific functions of the Wnt signaling system in gene regulatory networks throughout the early sea urchin embryo [Developmental Biology]

25-11-2014 | Miao Cui; Natnaree Siriwon; Enhu Li; Eric H. Davidson; Isabelle S. Peter, Proceedings of the National Academy of Sciences current issue, 2014

Wnt signaling affects cell-fate specification processes throughout embryonic development. Here we take advantage of the well-studied gene regulatory networks (GRNs) that control pregastrular sea urchin embryogenesis to reveal the gene regulatory functions of the entire Wnt-signaling system. Five ...

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Cells infected with herpes simplex virus 1 export to uninfected cells exosomes containing STING, viral mRNAs, and microRNAs [Microbiology]

18-11-2014 | Maria Kalamvoki; Te Du; Bernard Roizman, Proceedings of the National Academy of Sciences current issue, 2014

STING (stimulator of IFN genes) activates the IFN-dependent innate immune response to infection on sensing the presence of DNA in cytosol. The quantity of STING accumulating in cultured cells varies; it is relatively high in some cell lines [e.g., HEp-2, human embryonic lung fibroblasts (HEL), ...

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siRNAs from an X-linked satellite repeat promote X-chromosome recognition in Drosophila melanogaster [Genetics]

18-11-2014 | Debashish U. Menon; Cristian Coarfa; Weimin Xiao; Preethi H. Gunaratne; Victoria H. Meller, Proceedings of the National Academy of Sciences current issue, 2014

Highly differentiated sex chromosomes create a lethal imbalance in gene expression in one sex. To accommodate hemizygosity of the X chromosome in male fruit flies, expression of X-linked genes increases twofold. This is achieved by the male- specific lethal (MSL) complex, which modifies chromatin ...

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