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1,010 Newest Publications in proceedings of the national academy of sciences current issue

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Molecular transitions from papillomavirus infection to cervical precancer and cancer: Role of stromal estrogen receptor signaling [Medical Sciences]

23-Jun-2015 | Johan A. den Boon; Dohun Pyeon; Sophia S. Wang; Mark Horswill; Mark Schiffman; Mark Sherman; Rosemary E. Zuna; Zhish ..., Proceedings of the National Academy of Sciences current issue, 2015

To study the multistep process of cervical cancer development, we analyzed 128 frozen cervical samples spanning normalcy, increasingly severe cervical intraepithelial neoplasia (CIN1– CIN3), and cervical cancer (CxCa) from multiple perspectives, revealing a cascade of progressive changes. ...

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RNASEK is required for internalization of diverse acid-dependent viruses [Microbiology]

23-Jun-2015 | Brent A. Hackett; Ari Yasunaga; Debasis Panda; Michael A. Tartell; Kaycie C. Hopkins; Scott E. Hensley; Sara Cherry, Proceedings of the National Academy of Sciences current issue, 2015

Viruses must gain entry into cells to establish infection. In general, viruses enter either at the plasma membrane or from intracellular endosomal compartments. Viruses that use endosomal pathways are dependent on the cellular factors that control this process; however, these genes have proven to ...

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Minimal genomes of mycoplasma-related endobacteria are plastic and contain host-derived genes for sustained life within Glomeromycota [Microbiology]

23-Jun-2015 | Mizue Naito; Joseph B. Morton; Teresa E. Pawlowska, Proceedings of the National Academy of Sciences current issue, 2015

Arbuscular mycorrhizal fungi (AMF, Glomeromycota) colonize roots of the majority of terrestrial plants. They provide essential minerals to their plant hosts and receive photosynthates in return. All major lineages of AMF harbor endobacteria classified as Mollicutes, and known as ...

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Scrambled and not-so-tiny genomes of fungal endosymbionts [Microbiology]

23-Jun-2015 | Chih-Horng Kuo, Proceedings of the National Academy of Sciences current issue, 2015

Symbiosis, defined as prolonged and close association of two or more different organisms, is a major driving force for expansion of biological diversity from genes to ecosystems. In the most intimate form, the symbiont lives inside the cells of its host, is heritable, and the two parties could no ...

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Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia [Genetics]

16-Jun-2015 | Bon-Kyoung Koo; Johan H. van Es; Maaike van den Born; Hans Clevers, Proceedings of the National Academy of Sciences current issue, 2015

Rnf43 (RING finger protein 43) and Znrf3 (zinc/RING finger protein 3) (RZ) are two closely related transmembrane E3 ligases, encoded by Wnt target genes, that remove surface Wnt (wingless-int) receptors. The two genes are mutated in various human cancers. Such tumors are predicted to be ...

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Evolutionary comparison reveals that diverging CTCF sites are signatures of ancestral topological associating domains borders [Evolution]

16-Jun-2015 | Carlos Gómez-Marín; Juan J. Tena; Rafael D. Acemel; Macarena López-Mayorga; Silvia Naranjo; Elisa de la Calle-Mustie ..., Proceedings of the National Academy of Sciences current issue, 2015

Increasing evidence in the last years indicates that the vast amount of regulatory information contained in mammalian genomes is organized in precise 3D chromatin structures. However, the impact of this spatial chromatin organization on gene expression and its degree of evolutionary conservation ...

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Next-generation sequencing in African Americans with colorectal cancer [Biological Sciences]

02-Jun-2015 | Hassan Ashktorab; Sudhir Varma; Hassan Brim, Proceedings of the National Academy of Sciences current issue, 2015

We read with interest the recent study by Guda et al. (1) on novel recurrently mutated genes in African Americans with colorectal cancer (CRC). We have also recently published a similar study on African Americans from the Washington, DC area in which we reported novel mutations within known ...

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Angelman syndrome imprinting center encodes a transcriptional promoter [Colloquium Paper]

02-Jun-2015 | Michael W. Lewis; Jason O. Brant; Joseph M. Kramer; James I. Moss; Thomas P. Yang; Peter J. Hansen; R. Stan Williams ..., Proceedings of the National Academy of Sciences current issue, 2015

Clusters of imprinted genes are often controlled by an imprinting center that is necessary for allele-specific gene expression and to reprogram parent-of-origin information between generations. An imprinted domain at 15q11–q13 is responsible for both Angelman syndrome (AS) and Prader–Willi ...

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Monoallelic expression of the human FOXP2 speech gene [Colloquium Paper]

02-Jun-2015 | Abidemi A. Adegbola; Gerald F. Cox; Elizabeth M. Bradshaw; David A. Hafler; Alexander Gimelbrant; Andrew Chess, Proceedings of the National Academy of Sciences current issue, 2015

The recent descriptions of widespread random monoallelic expression (RMAE) of genes distributed throughout the autosomal genome indicate that there are more genes subject to RMAE on autosomes than the number of genes on the X chromosome where X-inactivation dictates RMAE of X-linked genes. ...

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Structural details of the OxyR peroxide-sensing mechanism [Microbiology]

19-May-2015 | Inseong Jo; In-Young Chung; Hee-Won Bae; Jin-Sik Kim; Saemee Song; You-Hee Cho; Nam-Chul Ha, Proceedings of the National Academy of Sciences current issue, 2015

OxyR, a bacterial peroxide sensor, is a LysR-type transcriptional regulator (LTTR) that regulates the transcription of defense genes in response to a low level of cellular H2O2. Consisting of an N-terminal DNA-binding domain (DBD) and a C-terminal regulatory domain (RD), OxyR senses H2O2 with ...

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