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886 Newest Publications in proceedings of the national academy of sciences current issue

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Protrudin binds atlastins and endoplasmic reticulum-shaping proteins and regulates network formation [Cell Biology]

10-09-2013 | Jaerak Chang; Seongju Lee; Craig Blackstone, Proceedings of the National Academy of Sciences current issue, 2013

Hereditary spastic paraplegias are inherited neurological disorders characterized by progressive lower-limb spasticity and weakness. Although more than 50 genetic loci are known [spastic gait (SPG)1 to -57], over half of hereditary spastic paraplegia cases are caused by pathogenic mutations in ...

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Integration of responses within and across Arabidopsis natural accessions uncovers loci controlling root systems architecture [Plant Biology]

10-09-2013 | Ulises Rosas; Angelica Cibrian-Jaramillo; Daniela Ristova; Joshua A. Banta; Miriam L. Gifford; Angela Huihui Fan; Ro ..., Proceedings of the National Academy of Sciences current issue, 2013

Phenotypic plasticity is presumed to be involved in adaptive change toward species diversification. We thus examined how candidate genes underlying natural variation across populations might also mediate plasticity within an individual. Our implementation of an integrative “plasticity space” ...

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Neutralization of terminal differentiation in gliomagenesis [Cell Biology]

03-09-2013 | Jian Hu; Allen L. Ho; Liang Yuan; Baoli Hu; Sujun Hua; Soyoon Sarah Hwang; Jianhua Zhang; Tianyi Hu; Hongwu Zheng; B ..., Proceedings of the National Academy of Sciences current issue, 2013

An immature state of cellular differentiation—characterized by stem cell–like tendencies and impaired differentiation—is a hallmark of cancer. Using glioblastoma multiforme (GBM) as a model system, we sought to determine whether molecular determinants that drive cells toward terminal ...

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Glucocorticoid receptor represses proinflammatory genes at distinct steps of the transcription cycle [Biochemistry]

03-09-2013 | Rebecca Gupte; Ginger W. Muse; Yurii Chinenov; Karen Adelman; Inez Rogatsky, Proceedings of the National Academy of Sciences current issue, 2013

Widespread anti-inflammatory actions of glucocorticoid hormones are mediated by the glucocorticoid receptor (GR), a ligand-dependent transcription factor of the nuclear receptor superfamily. In conjunction with its corepressor GR-interacting protein-1 (GRIP1), GR tethers to the DNA-bound ...

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Germ-line variant of human NTH1 DNA glycosylase induces genomic instability and cellular transformation [Genetics]

27-08-2013 | Heather A. Galick; Scott Kathe; Minmin Liu; Susan Robey-Bond; Dawit Kidane; Susan S. Wallace; Joann B. Sweasy, Proceedings of the National Academy of Sciences current issue, 2013

Base excision repair (BER) removes at least 20,000 DNA lesions per human cell per day and is critical for the maintenance of genomic stability. We hypothesize that aberrant BER, resulting from mutations in BER genes, can lead to genomic instability and cancer. The first step in BER is catalyzed ...

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Tandem oleosin genes in a cluster acquired in Brassicaceae created tapetosomes and conferred additive benefit of pollen vigor [Plant Biology]

27-08-2013 | Chien Yu Huang; Pei-Ying Chen; Ming-Der Huang; Chih-Hua Tsou; Wann-Neng Jane; Anthony H. C. Huang, Proceedings of the National Academy of Sciences current issue, 2013

During evolution, genomes expanded via whole-genome, segmental, tandem, and individual-gene duplications, and the emerged redundant paralogs would be eliminated or retained owing to selective neutrality or adaptive benefit and further functional divergence. Here we show that tandem paralogs can ...

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A high-throughput screen for quorum-sensing inhibitors that target acyl-homoserine lactone synthases [Biochemistry]

20-08-2013 | Quin H. Christensen; Tyler L. Grove; Squire J. Booker; E. Peter Greenberg, Proceedings of the National Academy of Sciences current issue, 2013

Many Proteobacteria use N-acyl-homoserine lactone (acyl-HSL) quorum sensing to control specific genes. Acyl-HSL synthesis requires unique enzymes that use S-adenosyl methionine as an acyl acceptor and amino acid donor. We developed and executed an enzyme-coupled high-throughput cell-free screen ...

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Creating memories of transcription [Systems Biology]

20-08-2013 | Ann L. Kirchmaier, Proceedings of the National Academy of Sciences current issue, 2013

Two genetically identical cells grown under the same conditions can exhibit stochastic fluctuations in gene expression. Such cell-to-cell variation in expression of key genes is hypothesized to help drive developmental fate decisions and cell specialization during differentiation. However, to ...

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Pinpointing genes underlying the quantitative trait loci for root-knot nematode resistance in palaeopolyploid soybean by whole genome resequencing [Genetics]

13-08-2013 | Xiangyang Xu; Liang Zeng; Ye Tao; Tri Vuong; Jinrong Wan; Roger Boerma; Jim Noe; Zenglu Li; Steve Finnerty; Safiulla ..., Proceedings of the National Academy of Sciences current issue, 2013

The objective of this study was to use next-generation sequencing technologies to dissect quantitative trait loci (QTL) for southern root-knot nematode (RKN) resistance into individual genes in soybean. Two hundred forty-six recombinant inbred lines (RIL) derived from a cross between Magellan ...

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Spherical nucleic acids: A whole new ball game [News Feature]

13-08-2013 | Sarah C. P. Williams, Proceedings of the National Academy of Sciences current issue, 2013

Spherical nucleic acids built from multiple strands of DNA dangling from a common center. This configuration drastically changes DNA’s physical and chemical properties. Spherical nucleic acids are revolutionizing drug delivery, gene therapy, and diagnostics. As the molecule that carries our genes ...

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