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948 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

Expression and prognostic impact of lncRNAs in acute myeloid leukemia [Medical Sciences]

30-Dec-2014 | Ramiro Garzon; Stefano Volinia; Dimitrios Papaioannou; Deedra Nicolet; Jessica Kohlschmidt; Pearlly S. Yan; Krzyszto ..., Proceedings of the National Academy of Sciences current issue, 2014

Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides, located within the intergenic stretches or overlapping antisense transcripts of protein coding genes. LncRNAs are involved in numerous biological roles including imprinting, epigenetic regulation, apoptosis, and cell ...

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STAT3 promotes survival of mutant photoreceptors in inherited photoreceptor degeneration models [Neuroscience]

30-Dec-2014 | Ke Jiang; Katherine L. Wright; Ping Zhu; Michael J. Szego; Alexa N. Bramall; William W. Hauswirth; Qiuhong Li; Sean ..., Proceedings of the National Academy of Sciences current issue, 2014

Inherited photoreceptor degenerations (IPDs), a group of incurable progressive blinding diseases, are caused by mutations in more than 200 genes, but little is known about the molecular pathogenesis of photoreceptor (PR) death. Increased retinal expression of STAT3 has been observed in response ...

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Epigenetic targeting of activation-induced cytidine deaminase [Immunology and Inflammation]

30-Dec-2014 | Qiao Wang; Thiago Oliveira; Mila Jankovic; Israel T. Silva; Ofir Hakim; Kaihui Yao; Anna Gazumyan; Christian T. Maye ..., Proceedings of the National Academy of Sciences current issue, 2014

Activation-induced cytidine deaminase (AID) initiates class switch recombination (CSR) and somatic hypermutation (SHM) by deaminating cytosine residues in immunoglobulin genes (Igh, Igκ, and Igλ). At a lower frequency, AID also causes collateral DNA damage at non-Ig loci, including genes that are ...

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Phytochrome controls alternative splicing to mediate light responses in Arabidopsis [Plant Biology]

30-Dec-2014 | Hiromasa Shikata; Kousuke Hanada; Tomokazu Ushijima; Moeko Nakashima; Yutaka Suzuki; Tomonao Matsushita, Proceedings of the National Academy of Sciences current issue, 2014

Plants monitor the ambient light conditions using several informational photoreceptors, including red/far-red light absorbing phytochrome. Phytochrome is widely believed to regulate the transcription of light-responsive genes by modulating the activity of several transcription factors. Here we ...

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Estrogen-related receptor {alpha} is required for efficient human cytomegalovirus replication [Microbiology]

30-Dec-2014 | Jesse Hwang; John G. Purdy; Kai Wu; Joshua D. Rabinowitz; Thomas Shenk, Proceedings of the National Academy of Sciences current issue, 2014

An shRNA-mediated screen of the 48 human nuclear receptor genes identified multiple candidates likely to influence the production of human cytomegalovirus in cultured human fibroblasts, including the estrogen-related receptor α (ERRα), an orphan nuclear receptor. The 50-kDa receptor and a 76-kDa ...

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Overexpression of Q-rich prion-like proteins suppresses polyQ cytotoxicity and alters the polyQ interactome [Biochemistry]

23-Dec-2014 | Leslie Ripaud; Victoria Chumakova; Matthias Antonin; Alex R. Hastie; Stefan Pinkert; Roman Körner; Kiersten M. Ruff; ..., Proceedings of the National Academy of Sciences current issue, 2014

Expansion of a poly-glutamine (polyQ) repeat in a group of functionally unrelated proteins is the cause of several inherited neurodegenerative disorders, including Huntington’s disease. The polyQ length-dependent aggregation and toxicity of these disease proteins can be reproduced in ...

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Neuromolecular responses to social challenge: Common mechanisms across mouse, stickleback fish, and honey bee [Evolution]

16-Dec-2014 | Clare C. Rittschof; Syed Abbas Bukhari; Laura G. Sloofman; Joseph M. Troy; Derek Caetano-Anollés; Amy Cash-Ahmed; Mo ..., Proceedings of the National Academy of Sciences current issue, 2014

Certain complex phenotypes appear repeatedly across diverse species due to processes of evolutionary conservation and convergence. In some contexts like developmental body patterning, there is increased appreciation that common molecular mechanisms underlie common phenotypes; these molecular ...

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Communication between oocytes and somatic cells regulates volatile pheromone production in Caenorhabditis elegans [Developmental Biology]

16-Dec-2014 | Daniel H. W. Leighton; Andrea Choe; Shannon Y Wu; Paul W. Sternberg, Proceedings of the National Academy of Sciences current issue, 2014

Males of the androdioecious species Caenorhabditis elegans are more likely to attempt to mate with and successfully inseminate C. elegans hermaphrodites that do not concurrently harbor sperm. Although a small number of genes have been implicated in this effect, the mechanism by which it arises ...

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A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome [Medical Sciences]

09-Dec-2014 | Simin Lu; Kohsuke Kanekura; Takashi Hara; Jana Mahadevan; Larry D. Spears; Christine M. Oslowski; Rita Martinez; May ..., Proceedings of the National Academy of Sciences current issue, 2014

Wolfram syndrome is a genetic disorder characterized by diabetes and neurodegeneration and considered as an endoplasmic reticulum (ER) disease. Despite the underlying importance of ER dysfunction in Wolfram syndrome and the identification of two causative genes, Wolfram syndrome 1 (WFS1) and ...

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Deficiencies in tRNA synthetase editing activity cause cardioproteinopathy [Genetics]

09-Dec-2014 | Ye Liu; Jakob S. Satz; My-Nuong Vo; Leslie A. Nangle; Paul Schimmel; Susan L. Ackerman, Proceedings of the National Academy of Sciences current issue, 2014

Misfolded proteins are an emerging hallmark of cardiac diseases. Although some misfolded proteins, such as desmin, are associated with mutations in the genes encoding these disease-associated proteins, little is known regarding more general mechanisms that contribute to the generation of ...

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