My watch list
my.chemeurope.com  
Login  

381 Newest Publications in proceedings of the national academy of sciences current issue

rss
matching the following criteria

Lack of pairing during meiosis triggers multigenerational transgene silencing in Caenorhabditis elegans [Genetics]

19-May-2015 | Luciana E. Leopold; Bree N. Heestand; Soobin Seong; Ludmila Shtessel; Shawn Ahmed, Proceedings of the National Academy of Sciences current issue, 2015

Single-copy transgenes in Caenorhabditis elegans can be subjected to a potent, irreversible silencing process termed small RNA-induced epigenetic silencing (RNAe). RNAe is promoted by the Piwi Argonaute protein PRG-1 and associated Piwi-interacting RNAs (piRNAs), as well as by proteins that ...

more

Characterizing the in vivo role of trehalose in Saccharomyces cerevisiae using the AGT1 transporter [Genetics]

12-May-2015 | Patrick A. Gibney; Ariel Schieler; Jonathan C. Chen; Joshua D. Rabinowitz; David Botstein, Proceedings of the National Academy of Sciences current issue, 2015

Trehalose is a highly stable, nonreducing disaccharide of glucose. A large body of research exists implicating trehalose in a variety of cellular phenomena, notably response to stresses of various kinds. However, in very few cases has the role of trehalose been examined directly in vivo. Here, we ...

more

Genetic differences and aberrant methylation in the apelin system predict the risk of high-altitude pulmonary edema [Genetics]

12-May-2015 | Aastha Mishra; Samantha Kohli; Sanchi Dua; Tashi Thinlas; Ghulam Mohammad; M. A. Qadar Pasha, Proceedings of the National Academy of Sciences current issue, 2015

Hypoxia-inducible factor stimulates the expression of apelin, a potent vasodilator, in response to reduced blood arterial oxygen saturation. However, aberrations in the apelin system impair pulmonary vascular function, potentially resulting in the development of high-altitude (HA)-related ...

more

Colon cancer-associated mutator DNA polymerase {delta} variant causes expansion of dNTP pools increasing its own infidelity [Genetics]

12-May-2015 | Tony M. Mertz; Sushma Sharma; Andrei Chabes; Polina V. Shcherbakova, Proceedings of the National Academy of Sciences current issue, 2015

Defects in DNA polymerases δ (Polδ) and ε (Polε) cause hereditary colorectal cancer and have been implicated in the etiology of some sporadic colorectal and endometrial tumors. We previously reported that the yeast pol3-R696W allele mimicking a human cancer-associated variant, POLD1-R689W, causes ...

more

Pools and Pols: Mechanism of a mutator phenotype [Genetics]

12-May-2015 | Christal D. Sohl; Sreerupa Ray; Joann B. Sweasy, Proceedings of the National Academy of Sciences current issue, 2015

The maintenance of the human genome is dependent upon several cellular processes including DNA replication. Ordinarily, DNA replication is an exceptionally faithful process, with approximately one error occurring for every 109–1010 nucleotides (1, 2). High-fidelity replicative DNA polymerases ...

more

Neither chimpanzee nor human, Ardipithecus reveals the surprising ancestry of both [Biological Sciences]

21-Apr-2015 | Tim D. White; C. Owen Lovejoy; Berhane Asfaw; Joshua P. Carlson; Gen Suwa, Proceedings of the National Academy of Sciences current issue, 2015

Australopithecus fossils were regularly interpreted during the late 20th century in a framework that used living African apes, especially chimpanzees, as proxies for the immediate ancestors of the human clade. Such projection is now largely nullified by the discovery of Ardipithecus. In the ...

more

Maternal and zygotic Zfp57 modulate NOTCH signaling in cardiac development [Genetics]

21-Apr-2015 | Yulia Shamis; Dana E. Cullen; Lizhi Liu; Guan Yang; Sheau-Fang Ng; Lijuan Xiao; Fong T. Bell; Chelsea Ray; Sachiko T ..., Proceedings of the National Academy of Sciences current issue, 2015

Zfp57 is a maternal–zygotic effect gene that maintains genomic imprinting. Here we report that Zfp57 mutants exhibited a variety of cardiac defects including atrial septal defect (ASD), ventricular septal defect (VSD), thin myocardium, and reduced trabeculation. Zfp57 maternal-zygotic mutant ...

more

Telomere dysfunction causes alveolar stem cell failure [Genetics]

21-Apr-2015 | Jonathan K. Alder; Christina E. Barkauskas; Nathachit Limjunyawong; Susan E. Stanley; Frant Kembou; Rubin M. Tuder; ..., Proceedings of the National Academy of Sciences current issue, 2015

Telomere syndromes have their most common manifestation in lung disease that is recognized as idiopathic pulmonary fibrosis and emphysema. In both conditions, there is loss of alveolar integrity, but the underlying mechanisms are not known. We tested the capacity of alveolar epithelial and ...

more

Evolution of the rapidly mutating human salivary agglutinin gene (DMBT1) and population subsistence strategy [Genetics]

21-Apr-2015 | Shamik Polley; Sandra Louzada; Diego Forni; Manuela Sironi; Theodosius Balaskas; David S. Hains; Fengtang Yang; Edwa ..., Proceedings of the National Academy of Sciences current issue, 2015

The dietary change resulting from the domestication of plant and animal species and development of agriculture at different locations across the world was one of the most significant changes in human evolution. An increase in dietary carbohydrates caused an increase in dental caries following the ...

more

Sae2 promotes DNA damage resistance by removing the Mre11-Rad50-Xrs2 complex from DNA and attenuating Rad53 signaling [Genetics]

14-Apr-2015 | Huan Chen; Roberto A. Donnianni; Naofumi Handa; Sarah K. Deng; Julyun Oh; Leonid A. Timashev; Stephen C. Kowalczykow ..., Proceedings of the National Academy of Sciences current issue, 2015

The Mre11–Rad50–Xrs2/NBS1 (MRX/N) nuclease/ATPase complex plays structural and catalytic roles in the repair of DNA double-strand breaks (DSBs) and is the DNA damage sensor for Tel1/ATM kinase activation. Saccharomyces cerevisiae Sae2 can function with MRX to initiate 5′-3′ end resection and also ...

more

Page 1 From 39
Subscribe to e-mail updates relating to your search

You will receive via e-mail the latest search results matching your search criteria. This service is free of charge and can be cancelled at any time.

Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE