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392 Newest Publications in proceedings of the national academy of sciences current issue

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Reanalysis of parabiosis of obesity mutants in the age of leptin [Genetics]

21-Jul-2015 | Wenwen Zeng; Yi-Hsueh Lu; Jonah Lee; Jeffrey M. Friedman, Proceedings of the National Academy of Sciences current issue, 2015

In this study we set out to explain the differing effects of parabiosis with genetically diabetic (db) mice versus administration of recombinant leptin. Parabiosis of db mutant, which overexpress leptin, to wildtype (WT) or genetically obese (ob) mice has been reported to cause death by ...

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microRNAs and inherited retinal dystrophies [Genetics]

21-Jul-2015 | Shunbin Xu, Proceedings of the National Academy of Sciences current issue, 2015

Inherited retinal dystrophies (IRD) are a heterogeneous group of blinding diseases that affect more than 200,000 Americans and millions worldwide (1). Identification of genes that are responsible for IRD when defective is of great importance to the basic understanding as well as development of ...

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In the light of evolution IX: Clonal reproduction: Alternatives to sex [Introductions]

21-Jul-2015 | Michel Tibayrenc; John C. Avise; Francisco J. Ayala, Proceedings of the National Academy of Sciences current issue, 2015

Evolutionary studies of clonal organisms have advanced considerably in recent years, but are still fledgling. Although recent textbooks on evolution or genetics might give the impression that nonsexual reproduction is an anomaly in the living world, clonality is the rule rather than the exception ...

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Drosophila circadian rhythms in seminatural environments: Summer afternoon component is not an artifact and requires TrpA1 channels [Genetics]

14-Jul-2015 | Edward W. Green; Emma K. O’Callaghan; Celia N. Hansen; Stefano Bastianello; Supriya Bhutani; Stefano Vanin; James Do ..., Proceedings of the National Academy of Sciences current issue, 2015

Under standard laboratory conditions of rectangular light/dark cycles and constant warm temperature, Drosophila melanogaster show bursts of morning (M) and evening (E) locomotor activity and a “siesta” in the middle of the day. These M and E components have been critical for developing the ...

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Genome-wide binding and mechanistic analyses of Smchd1-mediated epigenetic regulation [Genetics]

07-Jul-2015 | Kelan Chen; Jiang Hu; Darcy L. Moore; Ruijie Liu; Sarah A. Kessans; Kelsey Breslin; Isabelle S. Lucet; Andrew Keniry ..., Proceedings of the National Academy of Sciences current issue, 2015

Structural maintenance of chromosomes flexible hinge domain containing 1 (Smchd1) is an epigenetic repressor with described roles in X inactivation and genomic imprinting, but Smchd1 is also critically involved in the pathogenesis of facioscapulohumeral dystrophy. The underlying molecular ...

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Genetic and epigenetic architecture of sex-biased expression in the jewel wasps Nasonia vitripennis and giraulti [Genetics]

07-Jul-2015 | Xu Wang; John H. Werren; Andrew G. Clark, Proceedings of the National Academy of Sciences current issue, 2015

There is extraordinary diversity in sexual dimorphism (SD) among animals, but little is known about its epigenetic basis. To study the epigenetic architecture of SD in a haplodiploid system, we performed RNA-seq and whole-genome bisulfite sequencing of adult females and males from two closely ...

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Reduction of toxic RNAs in myotonic dystrophies type 1 and type 2 by the RNA helicase p68/DDX5 [Genetics]

30-Jun-2015 | Karlie Jones; Christina Wei; Benedikt Schoser; Giovanni Meola; Nikolai Timchenko; Lubov Timchenko, Proceedings of the National Academy of Sciences current issue, 2015

Myotonic dystrophies type 1 (DM1) and type 2 (DM2) are neuromuscular diseases, caused by accumulation of CUG and CCUG RNAs in toxic aggregates. Here we report that the increased stability of the mutant RNAs in both types of DM is caused by deficiency of RNA helicase p68. We have identified...

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MiR-204 is responsible for inherited retinal dystrophy associated with ocular coloboma [Genetics]

23-Jun-2015 | Ivan Conte; Kristen D. Hadfield; Sara Barbato; Sabrina Carrella; Mariateresa Pizzo; Rajeshwari S. Bhat; Annamaria Ca ..., Proceedings of the National Academy of Sciences current issue, 2015

Ocular developmental disorders, including the group classified as microphthalmia, anophthalmia, and coloboma (MAC) and inherited retinal dystrophies, collectively represent leading causes of hereditary blindness. Characterized by extreme genetic and clinical heterogeneity, the separate groups ...

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Correction for Mishra et al., Genetic differences and aberrant methylation in the apelin system predict the risk of high-altitude pulmonary edema [Correction]

23-Jun-2015 | Proceedings of the National Academy of Sciences current issue, 2015

GENETICS Correction for “Genetic differences and aberrant methylation in the apelin system predict the risk of high-altitude pulmonary edema,” by Aastha Mishra, Samantha Kohli, Sanchi Dua, Tashi Thinlas, Ghulam Mohammad, and M. A. Qadar Pasha, which appeared in issue 19, May 12, 2015, of Proc ...

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Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia [Genetics]

16-Jun-2015 | Bon-Kyoung Koo; Johan H. van Es; Maaike van den Born; Hans Clevers, Proceedings of the National Academy of Sciences current issue, 2015

Rnf43 (RING finger protein 43) and Znrf3 (zinc/RING finger protein 3) (RZ) are two closely related transmembrane E3 ligases, encoded by Wnt target genes, that remove surface Wnt (wingless-int) receptors. The two genes are mutated in various human cancers. Such tumors are predicted to be ...

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