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332 Newest Publications in proceedings of the national academy of sciences current issue

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Genomic and transcriptomic analyses of the medicinal fungus Antrodia cinnamomea for its metabolite biosynthesis and sexual development [Genetics]

04-11-2014 | Mei-Yeh Jade Lu; Wen-Lang Fan; Woei-Fuh Wang; Tingchun Chen; Yi-Ching Tang; Fang-Hua Chu; Tun-Tschu Chang; Sheng-Yan ..., Proceedings of the National Academy of Sciences current issue, 2014

Antrodia cinnamomea, a polyporus mushroom of Taiwan, has long been used as a remedy for cancer, hypertension, and hangover, with an annual market of over $100 million (US) in Taiwan. We obtained a 32.15-Mb genome draft containing 9,254 genes. Genome ontology enrichment and pathway analyses shed ...

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Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegans [Genetics]

21-10-2014 | Ara B. Hwang; Eun-A Ryu; Murat Artan; Hsin-Wen Chang; Mohammad Humayun Kabir; Hyun-Jun Nam; Dongyeop Lee; Jae-Seong ..., Proceedings of the National Academy of Sciences current issue, 2014

Mild inhibition of mitochondrial respiration extends the lifespan of many species. In Caenorhabditis elegans, reactive oxygen species (ROS) promote longevity by activating hypoxia-inducible factor 1 (HIF-1) in response to reduced mitochondrial respiration. However, the physiological role and ...

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Loss of p53 induces cell proliferation via Ras-independent activation of the Raf/Mek/Erk signaling pathway [Genetics]

21-10-2014 | Matthias Drosten; Eleanor Y. M. Sum; Carmen G. Lechuga; Lucía Simón-Carrasco; Harrys K. C. Jacob; Raquel García-Medi ..., Proceedings of the National Academy of Sciences current issue, 2014

The Ras family of small GTPases constitutes a central node in the transmission of mitogenic stimuli to the cell cycle machinery. The ultimate receptor of these mitogenic signals is the retinoblastoma (Rb) family of pocket proteins, whose inactivation is a required step to license cell ...

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Autism spectrum disorder severity reflects the average contribution of de novo and familial influences [Genetics]

21-10-2014 | Elise B. Robinson; Kaitlin E. Samocha; Jack A. Kosmicki; Lauren McGrath; Benjamin M. Neale; Roy H. Perlis; Mark J. Daly, Proceedings of the National Academy of Sciences current issue, 2014

Autism spectrum disorders (ASDs) are a highly heterogeneous group of conditions—phenotypically and genetically—although the link between phenotypic variation and differences in genetic architecture is unclear. This study aimed to determine whether differences in cognitive impairment and symptom ...

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CHD8 regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors [Genetics]

21-10-2014 | Aarathi Sugathan; Marta Biagioli; Christelle Golzio; Serkan Erdin; Ian Blumenthal; Poornima Manavalan; Ashok Ragaven ..., Proceedings of the National Academy of Sciences current issue, 2014

Truncating mutations of chromodomain helicase DNA-binding protein 8 (CHD8), and of many other genes with diverse functions, are strong-effect risk factors for autism spectrum disorder (ASD), suggesting multiple mechanisms of pathogenesis. We explored the transcriptional networks that CHD8 ...

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Role for LSM genes in the regulation of circadian rhythms [Genetics]

21-10-2014 | Soledad Perez-Santángelo; Estefanía Mancini; Lauren J. Francey; Ruben Gustavo Schlaen; Ariel Chernomoretz; John B. H ..., Proceedings of the National Academy of Sciences current issue, 2014

Growing evidence suggests that core spliceosomal components differentially affect RNA processing of specific genes; however, whether changes in the levels or activities of these factors control specific signaling pathways is largely unknown. Here we show that some SM-like (LSM) genes, which ...

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Transformation of quiescent adult oligodendrocyte precursor cells into malignant glioma through a multistep reactivation process [Genetics]

07-10-2014 | Rui Pedro Galvao; Anita Kasina; Robert S. McNeill; Jordan E. Harbin; Oded Foreman; Roel G. W. Verhaak; Akiko Nishiya ..., Proceedings of the National Academy of Sciences current issue, 2014

How malignant gliomas arise in a mature brain remains a mystery, hindering the development of preventive and therapeutic interventions. We previously showed that oligodendrocyte precursor cells (OPCs) can be transformed into glioma when mutations are introduced perinatally. However, adult OPCs ...

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An extended Shine-Dalgarno sequence in mRNA functionally bypasses a vital defect in initiator tRNA [Genetics]

07-10-2014 | Sunil Shetty; HimaPriyanka Nadimpalli; Riyaz Ahmad Shah; Smriti Arora; Gautam Das; Umesh Varshney, Proceedings of the National Academy of Sciences current issue, 2014

Initiator tRNAs are special in their direct binding to the ribosomal P-site due to the hallmark occurrence of the three consecutive G-C base pairs (3GC pairs) in their anticodon stems. How the 3GC pairs function in this role, has remained unsolved. We show that mutations in either the mRNA or...

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Combined fluorescent and electron microscopic imaging unveils the specific properties of two classes of meiotic crossovers [Genetics]

16-09-2014 | Lorinda K. Anderson; Leslie D. Lohmiller; Xiaomin Tang; D. Boyd Hammond; Lauren Javernick; Lindsay Shearer; Sayantan ..., Proceedings of the National Academy of Sciences current issue, 2014

Crossovers (COs) shuffle genetic information and allow balanced segregation of homologous chromosomes during the first division of meiosis. In several organisms, mutants demonstrate that two molecularly distinct pathways produce COs. One pathway produces class I COs that exhibit interference ...

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Mutation of Plekha7 attenuates salt-sensitive hypertension in the rat [Genetics]

02-09-2014 | Bradley T. Endres; Jessica R. C. Priestley; Oleg Palygin; Michael J. Flister; Matthew J. Hoffman; Brian D. Weinberg; ..., Proceedings of the National Academy of Sciences current issue, 2014

PLEKHA7 (pleckstrin homology domain containing family A member 7) has been found in multiple studies as a candidate gene for human hypertension, yet functional data supporting this association are lacking. We investigated the contribution of this gene to the pathogenesis of salt-sensitive ...

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