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367 Newest Publications in proceedings of the national academy of sciences current issue

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Impacts of biological globalization in the Mediterranean: Unveiling the deep history of human-mediated gamebird dispersal [Genetics]

17-Mar-2015 | Giovanni Forcina; Monica Guerrini; Hein van Grouw; Brij K. Gupta; Panicos Panayides; Pantelis Hadjigerou; Omar F. Al ..., Proceedings of the National Academy of Sciences current issue, 2015

Humans have a long history of moving wildlife that over time has resulted in unprecedented biotic homogenization. It is, as a result, often unclear whether certain taxa are native to a region or naturalized, and how the history of human involvement in species dispersal has shaped present-day ...

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Epigenetic modification of the oxytocin receptor gene influences the perception of anger and fear in the human brain [Genetics]

17-Mar-2015 | Meghan H. Puglia; Travis S. Lillard; James P. Morris; Jessica J. Connelly, Proceedings of the National Academy of Sciences current issue, 2015

In humans, the neuropeptide oxytocin plays a critical role in social and emotional behavior. The actions of this molecule are dependent on a protein that acts as its receptor, which is encoded by the oxytocin receptor gene (OXTR). DNA methylation of OXTR, an epigenetic modification, directly ...

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Horizontal gene transfer and gene dosage drives adaptation to wood colonization in a tree pathogen [Genetics]

17-Mar-2015 | Braham Dhillon; Nicolas Feau; Andrea L. Aerts; Stéphanie Beauseigle; Louis Bernier; Alex Copeland; Adam Foster; Navd ..., Proceedings of the National Academy of Sciences current issue, 2015

Some of the most damaging tree pathogens can attack woody stems, causing lesions (cankers) that may be lethal. To identify the genomic determinants of wood colonization leading to canker formation, we sequenced the genomes of the poplar canker pathogen, Mycosphaerella populorum, and the closely ...

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Nonsense suppression by near-cognate tRNAs employs alternative base pairing at codon positions 1 and 3 [Genetics]

10-Mar-2015 | Bijoyita Roy; John D. Leszyk; David A. Mangus; Allan Jacobson, Proceedings of the National Academy of Sciences current issue, 2015

Premature termination codons (PTCs) in an mRNA ORF inactivate gene function by causing production of a truncated protein and destabilization of the mRNA. Readthrough of a PTC allows ribosomal A-site insertion of a near-cognate tRNA, leading to synthesis of a full-length protein from otherwise ...

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Mutations in early follicular lymphoma progenitors are associated with suppressed antigen presentation [Genetics]

10-Mar-2015 | Michael R. Green; Shingo Kihira; Chih Long Liu; Ramesh V. Nair; Raheleh Salari; Andrew J. Gentles; Jonathan Irish; H ..., Proceedings of the National Academy of Sciences current issue, 2015

Follicular lymphoma (FL) is incurable with conventional therapies and has a clinical course typified by multiple relapses after therapy. These tumors are genetically characterized by B-cell leukemia/lymphoma 2 (BCL2) translocation and mutation of genes involved in chromatin modification. By ...

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SWI/SNF chromatin remodeling regulates alcohol response behaviors in Caenorhabditis elegans and is associated with alcohol dependence in humans [Genetics]

10-Mar-2015 | Laura D. Mathies; GinaMari G. Blackwell; Makeda K. Austin; Alexis C. Edwards; Brien P. Riley; Andrew G. Davies; Jill ..., Proceedings of the National Academy of Sciences current issue, 2015

Alcohol abuse is a widespread and serious problem. Understanding the factors that influence the likelihood of abuse is important for the development of effective therapies. There are both genetic and environmental influences on the development of abuse, but it has been difficult to identify ...

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Balancing copy number in ribosomal DNA [Genetics]

03-Mar-2015 | John H. Malone, Proceedings of the National Academy of Sciences current issue, 2015

Ecologists recognize the balance of nature as a complex system that arises from interacting and connected parts; disturbing the balance can affect other species in nonlinear and dynamic ways. Like ecosystems, the cell and genome are extensively connected by an abundance of molecular interactions. ...

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Massively expedited genome-wide heritability analysis (MEGHA) [Statistics]

24-Feb-2015 | Tian Ge; Thomas E. Nichols; Phil H. Lee; Avram J. Holmes; Joshua L. Roffman; Randy L. Buckner; Mert R. Sabuncu; Jord ..., Proceedings of the National Academy of Sciences current issue, 2015

The discovery and prioritization of heritable phenotypes is a computational challenge in a variety of settings, including neuroimaging genetics and analyses of the vast phenotypic repositories in electronic health record systems and population-based biobanks. Classical estimates of heritability ...

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Constraints on the evolution of a doublesex target gene arising from doublesex's pleiotropic deployment [Genetics]

24-Feb-2015 | Shengzhan D. Luo; Bruce S. Baker, Proceedings of the National Academy of Sciences current issue, 2015

“Regulatory evolution,” that is, changes in a gene’s expression pattern through changes at its regulatory sequence, rather than changes at the coding sequence of the gene or changes of the upstream transcription factors, has been increasingly recognized as a pervasive evolution mechanism. Many ...

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Haploinsufficiency screen highlights two distinct groups of ribosomal protein genes essential for embryonic stem cell fate [Genetics]

17-Feb-2015 | Simon Fortier; Tara MacRae; Mélanie Bilodeau; Tobias Sargeant; Guy Sauvageau, Proceedings of the National Academy of Sciences current issue, 2015

In a functional genomics screen of mouse embryonic stem cells (ESCs) with nested hemizygous chromosomal deletions, we reveal that ribosomal protein (RP) genes are the most significant haploinsufficient determinants for embryoid body (EB) formation. Hemizygocity for three RP genes (Rps5, Rps14, or ...

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