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344 Newest Publications in proceedings of the national academy of sciences current issue

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Measuring missing heritability: Inferring the contribution of common variants [Genetics]

09-12-2014 | David Golan; Eric S. Lander; Saharon Rosset, Proceedings of the National Academy of Sciences current issue, 2014

Genome-wide association studies (GWASs), also called common variant association studies (CVASs), have uncovered thousands of genetic variants associated with hundreds of diseases. However, the variants that reach statistical significance typically explain only a small fraction of the ...

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Comparison of the transcriptional landscapes between human and mouse tissues [Genetics]

02-12-2014 | Shin Lin; Yiing Lin; Joseph R. Nery; Mark A. Urich; Alessandra Breschi; Carrie A. Davis; Alexander Dobin; Christophe ..., Proceedings of the National Academy of Sciences current issue, 2014

Although the similarities between humans and mice are typically highlighted, morphologically and genetically, there are many differences. To better understand these two species on a molecular level, we performed a comparison of the expression profiles of 15 tissues by deep RNA sequencing and ...

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High-throughput optical quantification of mechanosensory habituation reveals neurons encoding memory in Caenorhabditis elegans [Genetics]

02-12-2014 | Takuma Sugi; Yasuko Ohtani; Yuta Kumiya; Ryuji Igarashi; Masahiro Shirakawa, Proceedings of the National Academy of Sciences current issue, 2014

A major goal of neuroscience studies is to identify the neurons and molecules responsible for memory. Mechanosensory habituation in Caenorhabditis elegans is a simple form of learning and memory, in which a circuit of several sensory neurons and interneurons governs behavior. However, despite the ...

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Simultaneous sequencing of oxidized methylcytosines produced by TET/JBP dioxygenases in Coprinopsis cinerea [Genetics]

02-12-2014 | Lukas Chavez; Yun Huang; Khai Luong; Suneet Agarwal; Lakshminarayan M. Iyer; William A. Pastor; Virginia K. Hench; S ..., Proceedings of the National Academy of Sciences current issue, 2014

TET/JBP enzymes oxidize 5-methylpyrimidines in DNA. In mammals, the oxidized methylcytosines (oxi-mCs) function as epigenetic marks and likely intermediates in DNA demethylation. Here we present a method based on diglucosylation of 5-hydroxymethylcytosine (5hmC) to simultaneously map 5hmC, ...

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Circular permutation of a synthetic eukaryotic chromosome with the telomerator [Genetics]

02-12-2014 | Leslie A. Mitchell; Jef D. Boeke, Proceedings of the National Academy of Sciences current issue, 2014

Chromosome engineering is a major focus in the fields of systems biology, genetics, synthetic biology, and the functional analysis of genomes. Here, we describe the “telomerator,” a new synthetic biology device for use in Saccharomyces cerevisiae. The telomerator is designed to inducibly convert ...

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Comparative analysis of the domestic cat genome reveals genetic signatures underlying feline biology and domestication [Genetics]

02-12-2014 | Michael J. Montague; Gang Li; Barbara Gandolfi; Razib Khan; Bronwen L. Aken; Steven M. J. Searle; Patrick Minx; LaDe ..., Proceedings of the National Academy of Sciences current issue, 2014

Little is known about the genetic changes that distinguish domestic cat populations from their wild progenitors. Here we describe a high-quality domestic cat reference genome assembly and comparative inferences made with other cat breeds, wildcats, and other mammals. Based upon these comparisons, ...

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Synaptonemal complex extension from clustered telomeres mediates full-length chromosome pairing in Schmidtea mediterranea [Genetics]

02-12-2014 | Youbin Xiang; Danny E. Miller; Eric J. Ross; Alejandro Sánchez Alvarado; R. Scott Hawley, Proceedings of the National Academy of Sciences current issue, 2014

In the 1920s, József Gelei proposed that chromosome pairing in flatworms resulted from the formation of a telomere bouquet followed by the extension of synapsis from telomeres at the base of the bouquet, thus facilitating homolog pairing in a processive manner. A modern interpretation of Gelei’s ...

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Analysis of clock-regulated genes in Neurospora reveals widespread posttranscriptional control of metabolic potential [Cell Biology]

02-12-2014 | Jennifer M. Hurley; Arko Dasgupta; Jillian M. Emerson; Xiaoying Zhou; Carol S. Ringelberg; Nicole Knabe; Anna M. Lip ..., Proceedings of the National Academy of Sciences current issue, 2014

Neurospora crassa has been for decades a principal model for filamentous fungal genetics and physiology as well as for understanding the mechanism of circadian clocks. Eukaryotic fungal and animal clocks comprise transcription-translation–based feedback loops that control rhythmic transcription ...

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Single mutations in sasA enable a simpler {Delta}cikA gene network architecture with equivalent circadian properties [Genetics]

25-11-2014 | Ryan K. Shultzaberger; Joseph S. Boyd; Takeo Katsuki; Susan S. Golden; Ralph J. Greenspan, Proceedings of the National Academy of Sciences current issue, 2014

The circadian input kinase of the cyanobacterium Synechococcus elongatus PCC 7942 (CikA) is important both for synchronizing circadian rhythms with external environmental cycles and for transferring temporal information between the oscillator and the global transcriptional regulator RpaA ...

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Cross-species genetic exchange between visceral and cutaneous strains of Leishmania in the sand fly vector [Genetics]

25-11-2014 | Audrey Romano; Ehud Inbar; Alain Debrabant; Melanie Charmoy; Phillip Lawyer; Flavia Ribeiro-Gomes; Mourad Barhoumi; ..., Proceedings of the National Academy of Sciences current issue, 2014

Genetic exchange between Leishmania major strains during their development in the sand fly vector has been experimentally shown. To investigate the possibility of genetic exchange between different Leishmania species, a cutaneous strain of L. major and a visceral strain of Leishmania infantum, ...

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