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326 Newest Publications in proceedings of the national academy of sciences current issue

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Transformation of quiescent adult oligodendrocyte precursor cells into malignant glioma through a multistep reactivation process [Genetics]

07-10-2014 | Rui Pedro Galvao; Anita Kasina; Robert S. McNeill; Jordan E. Harbin; Oded Foreman; Roel G. W. Verhaak; Akiko Nishiya ..., Proceedings of the National Academy of Sciences current issue, 2014

How malignant gliomas arise in a mature brain remains a mystery, hindering the development of preventive and therapeutic interventions. We previously showed that oligodendrocyte precursor cells (OPCs) can be transformed into glioma when mutations are introduced perinatally. However, adult OPCs ...

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An extended Shine-Dalgarno sequence in mRNA functionally bypasses a vital defect in initiator tRNA [Genetics]

07-10-2014 | Sunil Shetty; HimaPriyanka Nadimpalli; Riyaz Ahmad Shah; Smriti Arora; Gautam Das; Umesh Varshney, Proceedings of the National Academy of Sciences current issue, 2014

Initiator tRNAs are special in their direct binding to the ribosomal P-site due to the hallmark occurrence of the three consecutive G-C base pairs (3GC pairs) in their anticodon stems. How the 3GC pairs function in this role, has remained unsolved. We show that mutations in either the mRNA or...

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Combined fluorescent and electron microscopic imaging unveils the specific properties of two classes of meiotic crossovers [Genetics]

16-09-2014 | Lorinda K. Anderson; Leslie D. Lohmiller; Xiaomin Tang; D. Boyd Hammond; Lauren Javernick; Lindsay Shearer; Sayantan ..., Proceedings of the National Academy of Sciences current issue, 2014

Crossovers (COs) shuffle genetic information and allow balanced segregation of homologous chromosomes during the first division of meiosis. In several organisms, mutants demonstrate that two molecularly distinct pathways produce COs. One pathway produces class I COs that exhibit interference ...

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Mutation of Plekha7 attenuates salt-sensitive hypertension in the rat [Genetics]

02-09-2014 | Bradley T. Endres; Jessica R. C. Priestley; Oleg Palygin; Michael J. Flister; Matthew J. Hoffman; Brian D. Weinberg; ..., Proceedings of the National Academy of Sciences current issue, 2014

PLEKHA7 (pleckstrin homology domain containing family A member 7) has been found in multiple studies as a candidate gene for human hypertension, yet functional data supporting this association are lacking. We investigated the contribution of this gene to the pathogenesis of salt-sensitive ...

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A critical reanalysis of the relationship between genomics and well-being [Genetics]

02-09-2014 | Nicholas J. L. Brown; Douglas A. MacDonald; Manoj Pratim Samanta; Harris L. Friedman; James C. Coyne, Proceedings of the National Academy of Sciences current issue, 2014

Fredrickson et al. [Fredrickson BL, et al. (2013) Proc Natl Acad Sci USA 110(33):13684–13689] claimed to have observed significant differences in gene expression related to hedonic and eudaimonic dimensions of well-being. Having closely examined both their claims and their data, we draw ...

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Enhanced killing of antibiotic-resistant bacteria enabled by massively parallel combinatorial genetics [Genetics]

26-08-2014 | Allen A. Cheng; Huiming Ding; Timothy K. Lu, Proceedings of the National Academy of Sciences current issue, 2014

New therapeutic strategies are needed to treat infections caused by drug-resistant bacteria, which constitute a major growing threat to human health. Here, we use a high-throughput technology to identify combinatorial genetic perturbations that can enhance the killing of drug-resistant bacteria ...

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Correction for Koh et al., Noninvasive in vivo monitoring of tissue-specific global gene expression in humans [Correction]

29-07-2014 | Proceedings of the National Academy of Sciences current issue, 2014

GENETICS Correction for “Noninvasive in vivo monitoring of tissue-specific global gene expression in humans,” by Winston Koh, Wenying Pan, Charles Gawad, H. Christina Fan, Geoffrey A. Kerchner, Tony Wyss-Coray, Yair J. Blumenfeld, Yasser Y. El-Sayed, and Stephen R. Quake, which appeared in issue ...

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Synergistic tumor suppression by combined inhibition of telomerase and CDKN1A [Genetics]

29-07-2014 | Romi Gupta; Yuying Dong; Peter D. Solomon; Hiromi I. Wettersten; Christopher J. Cheng; JIn-Na Min; Jeremy Henson; Sh ..., Proceedings of the National Academy of Sciences current issue, 2014

Tumor suppressor p53 plays an important role in mediating growth inhibition upon telomere dysfunction. Here, we show that loss of the p53 target gene cyclin-dependent kinase inhibitor 1A (CDKN1A, also known as p21WAF1/CIP1) increases apoptosis induction following telomerase inhibition in a ...

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Extensive pathogenicity of mitochondrial heteroplasmy in healthy human individuals [Genetics]

22-07-2014 | Kaixiong Ye; Jian Lu; Fei Ma; Alon Keinan; Zhenglong Gu, Proceedings of the National Academy of Sciences current issue, 2014

A majority of mitochondrial DNA (mtDNA) mutations reported to be implicated in diseases are heteroplasmic, a status with coexisting mtDNA variants in a single cell. Quantifying the prevalence of mitochondrial heteroplasmy and its pathogenic effect in healthy individuals could further our ...

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Mutation of a major CG methylase in rice causes genome-wide hypomethylation, dysregulated genome expression, and seedling lethality [Genetics]

22-07-2014 | Lanjuan Hu; Ning Li; Chunming Xu; Silin Zhong; Xiuyun Lin; Jingjing Yang; Tianqi Zhou; Anzhi Yuliang; Ying Wu; Yun-R ..., Proceedings of the National Academy of Sciences current issue, 2014

Cytosine methylation at CG sites (mCG) plays critical roles in development, epigenetic inheritance, and genome stability in mammals and plants. In the dicot model plant Arabidopsis thaliana, methyltransferase 1 (MET1), a principal CG methylase, functions to maintain mCG during DNA replication, ...

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