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369 Newest Publications in proceedings of the national academy of sciences current issue

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Molecular coevolution of a sex pheromone and its receptor triggers reproductive isolation in Schizosaccharomyces pombe [Genetics]

07-Apr-2015 | Taisuke Seike; Taro Nakamura; Chikashi Shimoda, Proceedings of the National Academy of Sciences current issue, 2015

The diversification of sex pheromones is regarded as one of the causes of prezygotic isolation that results in speciation. In the fission yeast Schizosaccharomyces pombe, the molecular recognition of a peptide pheromone by its receptor plays an essential role in sexual reproduction. We considered ...

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Silencing of end-joining repair for efficient site-specific gene insertion after TALEN/CRISPR mutagenesis in Aedes aegypti [Genetics]

31-Mar-2015 | Sanjay Basu; Azadeh Aryan; Justin M. Overcash; Glady Hazitha Samuel; Michelle A. E. Anderson; Timothy J. Dahlem; Kev ..., Proceedings of the National Academy of Sciences current issue, 2015

Conventional control strategies for mosquito-borne pathogens such as malaria and dengue are now being complemented by the development of transgenic mosquito strains reprogrammed to generate beneficial phenotypes such as conditional sterility or pathogen resistance. The widespread success of ...

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Impacts of biological globalization in the Mediterranean: Unveiling the deep history of human-mediated gamebird dispersal [Genetics]

17-Mar-2015 | Giovanni Forcina; Monica Guerrini; Hein van Grouw; Brij K. Gupta; Panicos Panayides; Pantelis Hadjigerou; Omar F. Al ..., Proceedings of the National Academy of Sciences current issue, 2015

Humans have a long history of moving wildlife that over time has resulted in unprecedented biotic homogenization. It is, as a result, often unclear whether certain taxa are native to a region or naturalized, and how the history of human involvement in species dispersal has shaped present-day ...

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Epigenetic modification of the oxytocin receptor gene influences the perception of anger and fear in the human brain [Genetics]

17-Mar-2015 | Meghan H. Puglia; Travis S. Lillard; James P. Morris; Jessica J. Connelly, Proceedings of the National Academy of Sciences current issue, 2015

In humans, the neuropeptide oxytocin plays a critical role in social and emotional behavior. The actions of this molecule are dependent on a protein that acts as its receptor, which is encoded by the oxytocin receptor gene (OXTR). DNA methylation of OXTR, an epigenetic modification, directly ...

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Horizontal gene transfer and gene dosage drives adaptation to wood colonization in a tree pathogen [Genetics]

17-Mar-2015 | Braham Dhillon; Nicolas Feau; Andrea L. Aerts; Stéphanie Beauseigle; Louis Bernier; Alex Copeland; Adam Foster; Navd ..., Proceedings of the National Academy of Sciences current issue, 2015

Some of the most damaging tree pathogens can attack woody stems, causing lesions (cankers) that may be lethal. To identify the genomic determinants of wood colonization leading to canker formation, we sequenced the genomes of the poplar canker pathogen, Mycosphaerella populorum, and the closely ...

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Nonsense suppression by near-cognate tRNAs employs alternative base pairing at codon positions 1 and 3 [Genetics]

10-Mar-2015 | Bijoyita Roy; John D. Leszyk; David A. Mangus; Allan Jacobson, Proceedings of the National Academy of Sciences current issue, 2015

Premature termination codons (PTCs) in an mRNA ORF inactivate gene function by causing production of a truncated protein and destabilization of the mRNA. Readthrough of a PTC allows ribosomal A-site insertion of a near-cognate tRNA, leading to synthesis of a full-length protein from otherwise ...

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Mutations in early follicular lymphoma progenitors are associated with suppressed antigen presentation [Genetics]

10-Mar-2015 | Michael R. Green; Shingo Kihira; Chih Long Liu; Ramesh V. Nair; Raheleh Salari; Andrew J. Gentles; Jonathan Irish; H ..., Proceedings of the National Academy of Sciences current issue, 2015

Follicular lymphoma (FL) is incurable with conventional therapies and has a clinical course typified by multiple relapses after therapy. These tumors are genetically characterized by B-cell leukemia/lymphoma 2 (BCL2) translocation and mutation of genes involved in chromatin modification. By ...

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SWI/SNF chromatin remodeling regulates alcohol response behaviors in Caenorhabditis elegans and is associated with alcohol dependence in humans [Genetics]

10-Mar-2015 | Laura D. Mathies; GinaMari G. Blackwell; Makeda K. Austin; Alexis C. Edwards; Brien P. Riley; Andrew G. Davies; Jill ..., Proceedings of the National Academy of Sciences current issue, 2015

Alcohol abuse is a widespread and serious problem. Understanding the factors that influence the likelihood of abuse is important for the development of effective therapies. There are both genetic and environmental influences on the development of abuse, but it has been difficult to identify ...

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Balancing copy number in ribosomal DNA [Genetics]

03-Mar-2015 | John H. Malone, Proceedings of the National Academy of Sciences current issue, 2015

Ecologists recognize the balance of nature as a complex system that arises from interacting and connected parts; disturbing the balance can affect other species in nonlinear and dynamic ways. Like ecosystems, the cell and genome are extensively connected by an abundance of molecular interactions. ...

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Massively expedited genome-wide heritability analysis (MEGHA) [Statistics]

24-Feb-2015 | Tian Ge; Thomas E. Nichols; Phil H. Lee; Avram J. Holmes; Joshua L. Roffman; Randy L. Buckner; Mert R. Sabuncu; Jord ..., Proceedings of the National Academy of Sciences current issue, 2015

The discovery and prioritization of heritable phenotypes is a computational challenge in a variety of settings, including neuroimaging genetics and analyses of the vast phenotypic repositories in electronic health record systems and population-based biobanks. Classical estimates of heritability ...

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