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287 Newest Publications in proceedings of the national academy of sciences current issue
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matching the following criteria
Dnr1 mutations cause neurodegeneration in Drosophila by activating the innate immune response in the brain [Genetics]
07-05-2013 | Yang Cao; Stanislava Chtarbanova; Andrew J. Petersen; Barry Ganetzky, Proceedings of the National Academy of Sciences current issue, 2013
A growing body of evidence in humans implicates chronic activation of the innate immune response in the brain as a major cause of neuropathology in various neurodegenerative conditions, although the mechanisms remain unclear. In an unbiased genetic screen for mutants exhibiting ...
Correction for McManus et al., Global analysis of trans-splicing in Drosophila [Correction]
07-05-2013 | Proceedings of the National Academy of Sciences current issue, 2013
GENETICS Correction for “Global analysis of trans-splicing in Drosophila,” by C. Joel McManus, Michael O. Duff, Jodi Eipper-Mains, and Brenton R. Graveley, which appeared in issue 29, July 20, 2010, of Proc Natl Acad Sci USA (107:12975–12979; first published July 1, 2010; ...
Leptin resistance is a secondary consequence of the obesity in ciliopathy mutant mice [Genetics]
07-05-2013 | Nicolas F. Berbari; Raymond C. Pasek; Erik B. Malarkey; S. M. Zaki Yazdi; Andrew D. McNair; Wesley R. Lewis; Tim R. ..., Proceedings of the National Academy of Sciences current issue, 2013
Although primary cilia are well established as important sensory and signaling structures, their function in most tissues remains unknown. Obesity is a feature associated with some syndromes of cilia dysfunction, such as Bardet-Biedl syndrome (BBS) and Alström syndrome, as well as in several ...
Genomic rearrangements and the evolution of clusters of locally adaptive loci [Evolution]
07-05-2013 | Sam Yeaman, Proceedings of the National Academy of Sciences current issue, 2013
Numerous studies of ecological genetics have found that alleles contributing to local adaptation sometimes cluster together, forming “genomic islands of divergence.” Divergence hitchhiking theory posits that these clusters evolve by the preferential establishment of tightly linked locally ...
Accumulation of the FACT complex, as well as histone H3.3, serves as a target marker for somatic hypermutation [Genetics]
07-05-2013 | Masatoshi Aida; Nesreen Hamad; Andre Stanlie; Nasim A. Begum; Tasuku Honjo, Proceedings of the National Academy of Sciences current issue, 2013
Somatic hypermutation (SHM) requires not only the expression of activation-induced cytidine deaminase, but also transcription in the target regions. However, how transcription guides activation-induced cytidine deaminase in targeting SHM to the Ig genes is not fully understood. Here, we found ...
Position effect on FGF13 associated with X-linked congenital generalized hypertrichosis [Genetics]
07-05-2013 | Gina M. DeStefano; Katherine A. Fantauzzo; Lynn Petukhova; Mazen Kurban; Marija Tadin-Strapps; Brynn Levy; Dorothy W ..., Proceedings of the National Academy of Sciences current issue, 2013
X-linked congenital generalized hypertrichosis (Online Mendelian Inheritance in Man 307150) is an extremely rare condition of hair overgrowth on different body sites. We previously reported linkage in a large Mexican family with X-linked congenital generalized hypertrichosis cosegregating ...
Physical and genetic-interaction density reveals functional organization and informs significance cutoffs in genome-wide screens [Genetics]
30-04-2013 | John C. Dittmar; Steven Pierce; Rodney Rothstein; Robert J. D. Reid, Proceedings of the National Academy of Sciences current issue, 2013
Genome-wide experiments often measure quantitative differences between treated and untreated cells to identify affected strains. For these studies, statistical models are typically used to determine significance cutoffs. We developed a method termed “CLIK” (Cutoff Linked to Interaction ...
Dosage compensation and inverse effects in triple X metafemales of Drosophila [Genetics]
30-04-2013 | Lin Sun; Adam F. Johnson; Ryan C. Donohue; Jilong Li; Jianlin Cheng; James A. Birchler, Proceedings of the National Academy of Sciences current issue, 2013
Dosage compensation, the equalized X chromosome gene expression between males and females in Drosophila, has also been found in triple X metafemales. Inverse dosage effects, produced by genomic imbalance, are believed to account for this modulated expression, but they have not been studied on ...
Diversity and heritability of the maize rhizosphere microbiome under field conditions [Microbiology]
16-04-2013 | Jason A. Peiffer; Aymé Spor; Omry Koren; Zhao Jin; Susannah Green Tringe; Jeffery L. Dangl; Edward S. Buckler; Ruth ..., Proceedings of the National Academy of Sciences current issue, 2013
The rhizosphere is a critical interface supporting the exchange of resources between plants and their associated soil environment. Rhizosphere microbial diversity is influenced by the physical and chemical properties of the rhizosphere, some of which are determined by the genetics of the host ...
Rig-I regulates NF-{kappa}B activity through binding to Nf-{kappa}b1 3'-UTR mRNA [Genetics]
16-04-2013 | Hong-Xin Zhang; Zi-Xing Liu; Yue-Ping Sun; Jiang Zhu; Shun-Yuan Lu; Xue-Song Liu; Qiu-Hua Huang; Yin-Yin Xie; Hou-Ba ..., Proceedings of the National Academy of Sciences current issue, 2013
Retinoic acid inducible gene I (RIG-I) senses viral RNAs and triggers innate antiviral responses through induction of type I IFNs and inflammatory cytokines. However, whether RIG-I interacts with host cellular RNA remains undetermined. Here we report that Rig-I interacts with multiple ...
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