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653 Newest Publications in proceedings of the national academy of sciences current issue

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Immuno-Navigator, a batch-corrected coexpression database, reveals cell type-specific gene networks in the immune system [Immunology and Inflammation]

26-Apr-2016 | Alexis Vandenbon; Viet H. Dinh; Norihisa Mikami; Yohko Kitagawa; Shunsuke Teraguchi; Naganari Ohkura; Shimon Sakaguchi, Proceedings of the National Academy of Sciences current issue, 2016

High-throughput gene expression data are one of the primary resources for exploring complex intracellular dynamics in modern biology. The integration of large amounts of public data may allow us to examine general dynamical relationships between regulators and target genes. However, obstacles for ...

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Dimethyl fumarate treatment induces adaptive and innate immune modulation independent of Nrf2 [Immunology and Inflammation]

26-Apr-2016 | Ulf Schulze-Topphoff; Michel Varrin-Doyer; Kara Pekarek; Collin M. Spencer; Aparna Shetty; Sharon A. Sagan; Bruce A. ..., Proceedings of the National Academy of Sciences current issue, 2016

Dimethyl fumarate (DMF) (BG-12, Tecfidera) is a fumaric acid ester (FAE) that was advanced as a multiple sclerosis (MS) therapy largely for potential neuroprotection as it was recognized that FAEs are capable of activating the antioxidative transcription factor nuclear factor (erythroid-derived ...

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Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood [Immunology and Inflammation]

26-Apr-2016 | Katrin Klocke; Shimon Sakaguchi; Rikard Holmdahl; Kajsa Wing, Proceedings of the National Academy of Sciences current issue, 2016

Cytotoxic T lymphocyte antigen-4 (CTLA-4) is essential for immunological (self-) tolerance, but due to the early fatality of CTLA-4 KO mice, its specific function in central and peripheral tolerance and in different systemic diseases remains to be determined. Here, we further examined the role of ...

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Nuclear transfer nTreg model reveals fate-determining TCR-{beta} and novel peripheral nTreg precursors [Immunology and Inflammation]

19-Apr-2016 | Manching Ku; Shih-En Chang; Julio Hernandez; Justin R. Abadejos; Mohsen Sabouri-Ghomi; Niklas J. Muenchmeier; Anna S ..., Proceedings of the National Academy of Sciences current issue, 2016

To study the development and function of “natural-arising” T regulatory (nTreg) cells, we developed a novel nTreg model on pure nonobese diabetic background using epigenetic reprogramming via somatic cell nuclear transfer. On RAG1-deficient background, we found that monoclonal FoxP3+ CD4+ Treg ...

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NLRP3 inflammasome plays a redundant role with caspase 8 to promote IL-1{beta}-mediated osteomyelitis [Immunology and Inflammation]

19-Apr-2016 | Prajwal Gurung; Amanda Burton; Thirumala-Devi Kanneganti, Proceedings of the National Academy of Sciences current issue, 2016

Missense mutation in the proline-serine-threonine phosphatase-interacting protein 2 (Pstpip2) gene results in the development of spontaneous chronic bone disease characterized by bone deformity and inflammation that is reminiscent of patients with chronic multifocal osteomyelitis (cmo). ...

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Monoclonal antibody therapy for Junin virus infection [Immunology and Inflammation]

19-Apr-2016 | Larry Zeitlin; Joan B. Geisbert; Daniel J. Deer; Karla A. Fenton; Ognian Bohorov; Natasha Bohorova; Charles Goodman; ..., Proceedings of the National Academy of Sciences current issue, 2016

Countermeasures against potential biothreat agents remain important to US Homeland Security, and many of these pharmaceuticals could have dual use in the improvement of global public health. Junin virus, the causative agent of Argentine hemorrhagic fever (AHF), is an arenavirus identified as a ...

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PGE2 induced in and released by dying cells functions as an inhibitory DAMP [Immunology and Inflammation]

05-Apr-2016 | Sho Hangai; Tomoka Ao; Yoshitaka Kimura; Kosuke Matsuki; Takeshi Kawamura; Hideo Negishi; Junko Nishio; Tatsuhiko Ko ..., Proceedings of the National Academy of Sciences current issue, 2016

Cellular components released into the external milieu as a result of cell death and sensed by the body are generally termed damage-associated molecular patterns (DAMPs). Although DAMPs are conventionally thought to be protective to the host by evoking inflammatory responses important for immunity ...

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Correction for Gaiser et al., Cancer-associated epithelial cell adhesion molecule (EpCAM; CD326) enables epidermal Langerhans cell motility and migration in vivo [Correction]

05-Apr-2016 | Proceedings of the National Academy of Sciences current issue, 2016

IMMUNOLOGY Correction for “Cancer-associated epithelial cell adhesion molecule (EpCAM; CD326) enables epidermal Langerhans cell motility and migration in vivo,” by Maria R. Gaiser, Tim Lämmermann, Xu Feng, Botond Z. Igyarto, Daniel H. Kaplan, Lino Tessarollo, Ronald N. Germain, and Mark C. Udey, ...

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Correction to Supporting Information for Wang et al., TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS [SI Correction]

05-Apr-2016 | Proceedings of the National Academy of Sciences current issue, 2016

IMMUNOLOGY AND INFLAMMATION Correction to Supporting Information for “TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS,” by Ying Wang, Lijing Su, Matthew D. Morin, Brian T. Jones, Landon R. Whitby, Murali M. R. P. Surakattula, Hua Huang, Hexin Shi, Jin Huk Choi, Kuan-wen ...

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Detection, phenotyping, and quantification of antigen-specific T cells using a peptide-MHC dodecamer [Immunology and Inflammation]

29-Mar-2016 | Jun Huang; Xun Zeng; Natalia Sigal; Peder J. Lund; Laura F. Su; Huang Huang; Yueh-hsiu Chien; Mark M. Davis, Proceedings of the National Academy of Sciences current issue, 2016

Here we report a peptide-MHC (pMHC) dodecamer as a “next generation” technology that is a significantly more sensitive and versatile alternative to pMHC tetramers for the detection, isolation, and phenotypic analysis of antigen-specific T cells. In particular, dodecamers are able to detect two- ...

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