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617 Newest Publications in proceedings of the national academy of sciences current issue

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Unstable FoxP3+ T regulatory cells in NZW mice [Immunology and Inflammation]

02-Feb-2016 | Fabien Dépis; Ho-Keun Kwon; Diane Mathis; Christophe Benoist, Proceedings of the National Academy of Sciences current issue, 2016

Regulatory T (Treg) cells that express the transcription factor FoxP3 play a key role in self-tolerance and the control of inflammation. In mice and humans, there is a wide interindividual range in Treg frequency, but little is known about the underlying genetic or epigenetic mechanisms. We ...

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Subtype-specific addiction of the activated B-cell subset of diffuse large B-cell lymphoma to FOXP1 [Immunology and Inflammation]

02-Feb-2016 | Joseph D. Dekker; Daechan Park; Arthur L. Shaffer III; Holger Kohlhammer; Wei Deng; Bum-Kyu Lee; Gregory C. Ippolito ..., Proceedings of the National Academy of Sciences current issue, 2016

High expression of the forkhead box P1 (FOXP1) transcription factor distinguishes the aggressive activated B cell (ABC) diffuse large B-cell lymphoma (DLBCL) subtype from the better prognosis germinal center B-cell (GCB)-DLBCL subtype and is highly correlated with poor outcomes. A genetic or ...

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Heightened self-reactivity associated with selective survival, but not expansion, of naive virus-specific CD8+ T cells in aged mice [Immunology and Inflammation]

02-Feb-2016 | Kylie M. Quinn; Sophie G. Zaloumis; Tania Cukalac; Wan-Ting Kan; Xavier Y. X. Sng; Michiko Mirams; Katherine A. Wats ..., Proceedings of the National Academy of Sciences current issue, 2016

In advanced age, decreased CD8+ cytotoxic T-lymphocyte (CTL) responses to novel pathogens and cancer is paralleled by a decline in the number and function of naïve CTL precursors (CTLp). Although the age-related fall in CD8+ T-cell numbers is well established, neither the underlying mechanisms ...

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LDL receptor-related protein-1 regulates NF{kappa}B and microRNA-155 in macrophages to control the inflammatory response [Immunology and Inflammation]

02-Feb-2016 | Elisabetta Mantuano; Coralie Brifault; Michael S. Lam; Pardis Azmoon; Andrew S. Gilder; Steven L. Gonias, Proceedings of the National Academy of Sciences current issue, 2016

LDL receptor-related protein-1 (LRP1) is an endocytic and cell-signaling receptor. In mice in which LRP1 is deleted in myeloid cells, the response to lipopolysaccharide (LPS) was greatly exacerbated. LRP1 deletion in macrophages in vitro, under the control of tamoxifen-activated Cre-ERT fusion ...

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Autoimmune vitiligo is associated with gain-of-function by a transcriptional regulator that elevates expression of HLA-A*02:01 in vivo [Immunology and Inflammation]

02-Feb-2016 | Masahiro Hayashi; Ying Jin; Daniel Yorgov; Stephanie A. Santorico; James Hagman; Tracey M. Ferrara; Kenneth L. Jones ..., Proceedings of the National Academy of Sciences current issue, 2016

HLA-A is a class I major histocompatibility complex receptor that presents peptide antigens on the surface of most cells. Vitiligo, an autoimmune disease in which skin melanocytes are destroyed by cognate T cells, is associated with variation in the HLA-A gene; specifically HLA-A*02:01, which ...

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Hyaluronan synthesis is necessary for autoreactive T-cell trafficking, activation, and Th1 polarization [Immunology and Inflammation]

02-Feb-2016 | Hedwich F. Kuipers; Mary Rieck; Irina Gurevich; Nadine Nagy; Manish J. Butte; Robert S. Negrin; Thomas N. Wight; Law ..., Proceedings of the National Academy of Sciences current issue, 2016

The extracellular matrix polysaccharide hyaluronan (HA) accumulates at sites of autoimmune inflammation, including white matter lesions in multiple sclerosis (MS), but its functional importance in pathogenesis is unclear. We have evaluated the impact of 4-methylumbelliferone (4-MU), an oral ...

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Utilization of a photoactivatable antigen system to examine B-cell probing termination and the B-cell receptor sorting mechanisms during B-cell activation [Immunology and Inflammation]

02-Feb-2016 | Jing Wang; Shan Tang; Zhengpeng Wan; Yiren Gao; Yiyun Cao; Junyang Yi; Yanyan Si; Haowen Zhang; Lei Liu; Wanli Liu, Proceedings of the National Academy of Sciences current issue, 2016

Antigen binding to the B-cell receptor (BCR) induces several responses, resulting in B-cell activation, proliferation, and differentiation. However, it has been difficult to study these responses due to their dynamic, fast, and transient nature. Here, we attempted to solve this problem by ...

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Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution [Immunology and Inflammation]

26-Jan-2016 | Yun-Hee Youm; Tamas L. Horvath; David J. Mangelsdorf; Steven A. Kliewer; Vishwa Deep Dixit, Proceedings of the National Academy of Sciences current issue, 2016

Age-related thymic degeneration is associated with loss of naïve T cells, restriction of peripheral T-cell diversity, and reduced healthspan due to lower immune competence. The mechanistic basis of age-related thymic demise is unclear, but prior evidence suggests that caloric restriction (CR) can ...

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Imaging of the cross-presenting dendritic cell subsets in the skin-draining lymph node [Immunology and Inflammation]

26-Jan-2016 | Masahiro Kitano; Chihiro Yamazaki; Akiko Takumi; Takashi Ikeno; Hiroaki Hemmi; Noriko Takahashi; Kanako Shimizu; Sco ..., Proceedings of the National Academy of Sciences current issue, 2016

Dendritic cells (DCs) are antigen-presenting cells specialized for activating T cells to elicit effector T-cell functions. Cross-presenting DCs are a DC subset capable of presenting antigens to CD8+ T cells and play critical roles in cytotoxic T-cell–mediated immune responses to microorganisms ...

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Surface expression, peptide repertoire, and thermostability of chicken class I molecules correlate with peptide transporter specificity [Immunology and Inflammation]

19-Jan-2016 | Clive A. Tregaskes; Michael Harrison; Anna K. Sowa; Andy van Hateren; Lawrence G. Hunt; Olli Vainio; Jim Kaufman, Proceedings of the National Academy of Sciences current issue, 2016

The chicken major histocompatibility complex (MHC) has strong genetic associations with resistance and susceptibility to certain infectious pathogens. The cell surface expression level of MHC class I molecules varies as much as 10-fold between chicken haplotypes and is inversely correlated with ...

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