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539 Newest Publications in proceedings of the national academy of sciences current issue

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Molecular basis for the specific recognition of the metazoan cyclic GMP-AMP by the innate immune adaptor protein STING [Immunology and Inflammation]

21-Jul-2015 | Heping Shi; Jiaxi Wu; Zhijian J. Chen; Chuo Chen, Proceedings of the National Academy of Sciences current issue, 2015

Cyclic GMP-AMP containing a unique combination of mixed phosphodiester linkages (2′3′-cGAMP) is an endogenous second messenger molecule that activates the type-I IFN pathway upon binding to the homodimer of the adaptor protein STING on the surface of endoplasmic reticulum membrane. However, the ...

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CD300f associates with IL-4 receptor {alpha} and amplifies IL-4-induced immune cell responses [Immunology and Inflammation]

14-Jul-2015 | Itay Moshkovits; Danielle Karo-Atar; Michal Itan; Hadar Reichman; Perri Rozenberg; Netali Morgenstern-Ben-Baruch; Da ..., Proceedings of the National Academy of Sciences current issue, 2015

IL-4 receptor (R) α, the common receptor chain for IL-4 and IL-13, is a critical component in IL-4– and IL-13–mediated signaling and subsequent effector functions such as those observed in type 2 inflammatory responses. Nonetheless, the existence of intrinsic pathways capable of amplifying ...

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Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA [Immunology and Inflammation]

07-Jul-2015 | Anne-Claire Duchez; Luc H. Boudreau; James Bollinger; Clémence Belleannée; Nathalie Cloutier; Benoit Laffont; Raifis ..., Proceedings of the National Academy of Sciences current issue, 2015

Platelets are anucleated blood elements highly potent at generating extracellular vesicles (EVs) called microparticles (MPs). Whereas EVs are accepted as an important means of intercellular communication, the mechanisms underlying platelet MP internalization in recipient cells are poorly ...

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CD14 dependence of TLR4 endocytosis and TRIF signaling displays ligand specificity and is dissociable in endotoxin tolerance [Immunology and Inflammation]

07-Jul-2015 | Rajesh Rajaiah; Darren J. Perkins; Derek D. C. Ireland; Stefanie N. Vogel, Proceedings of the National Academy of Sciences current issue, 2015

Dimerization of Toll-like receptor 4 (TLR4)/myeloid differentiation factor 2 (MD2) heterodimers is critical for both MyD88- and TIR-domain–containing adapter-inducing IFN-β (TRIF)-mediated signaling pathways. Recently, Zanoni et al. [(2011) Cell 147(4):868–880] reported that cluster of ...

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DC-SIGN activation mediates the differential effects of SAP and CRP on the innate immune system and inhibits fibrosis in mice [Immunology and Inflammation]

07-Jul-2015 | Nehemiah Cox; Darrell Pilling; Richard H. Gomer, Proceedings of the National Academy of Sciences current issue, 2015

Fibrosis is caused by scar tissue formation in internal organs and is associated with 45% of deaths in the United States. Two closely related human serum proteins, serum amyloid P (SAP) and C-reactive protein (CRP), strongly affect fibrosis. In multiple animal models, and in Phase 1 and Phase 2 ...

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Pre-T-cell receptor binds MHC: Implications for thymocyte signaling and selection [Immunology and Inflammation]

07-Jul-2015 | Xinbo Yang; Roy A. Mariuzza, Proceedings of the National Academy of Sciences current issue, 2015

T cells play a major role in producing adaptive immune responses to microbes and cancers. T-cell development occurs in the thymus, starting from hematopoietic stem cells. There, CD4–CD8– double-negative (DN) thymocytes that generate a functional T-cell receptor (TCR) β-chain express on their ...

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TOE1 is an inhibitor of HIV-1 replication with cell-penetrating capability [Immunology and Inflammation]

30-Jun-2015 | Sabina Sperandio; Corinne Barat; Miguel A. Cabrita; Ana Gargaun; Maxim V. Berezovski; Michel J. Tremblay; Ian de Belle, Proceedings of the National Academy of Sciences current issue, 2015

Target of Egr1 (TOE1) is a nuclear protein localized primarily in nucleoli and Cajal bodies that was identified as a downstream target of the immediate early gene Egr1. TOE1 displays a functional deadenylation domain and has been shown to participate in spliceosome assembly. We report here that ...

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Inflammation induces dermal V{gamma}4+ {gamma}{delta}T17 memory-like cells that travel to distant skin and accelerate secondary IL-17-driven responses [Immunology and Inflammation]

30-Jun-2015 | Francisco Ramírez-Valle; Elizabeth E. Gray; Jason G. Cyster, Proceedings of the National Academy of Sciences current issue, 2015

Gamma delta (γδ) T cells represent a major IL-17 committed T-cell population (γδT17 cells) in the mouse dermis. Following exposure to the inflammatory agent imiquimod (IMQ) the Vγ4+ subset of γδT cells produce IL-17 in the skin and expand rapidly in draining lymph nodes (LNs). Local IMQ treatment ...

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Disregulated expression of the transcription factor ThPOK during T-cell development leads to high incidence of T-cell lymphomas [Immunology and Inflammation]

23-Jun-2015 | Hyung-Ok Lee; Xiao He; Jayati Mookerjee-Basu; Dai Zhongping; Xiang Hua; Emmanuelle Nicolas; Maria Luisa Sulis; Adolf ..., Proceedings of the National Academy of Sciences current issue, 2015

The transcription factor T-helper-inducing POZ/Krueppel-like factor (ThPOK, encoded by the Zbtb7b gene) plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. Here we show that mice expressing a constitutive T-cell–specific ThPOK ...

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Inflammation negatively regulates FOXP3 and regulatory T-cell function via DBC1 [Immunology and Inflammation]

23-Jun-2015 | Yayi Gao; Jiayou Tang; Weiqian Chen; Qiang Li; Jia Nie; Fang Lin; Qingsi Wu; Zuojia Chen; Zhimei Gao; Huimin Fan; An ..., Proceedings of the National Academy of Sciences current issue, 2015

Forkhead box P3 (FOXP3)-positive Treg cells are crucial for maintaining immune homeostasis. FOXP3 cooperates with its binding partners to elicit Treg cells’ signature and function, but the molecular mechanisms underlying the modulation of the FOXP3 complex remain unclear. Here we report that ...

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