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467 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

Molecular architecture of the {alpha}{beta} T cell receptor-CD3 complex [Immunology and Inflammation]

09-12-2014 | Michael E. Birnbaum; Richard Berry; Yu-Shan Hsiao; Zhenjun Chen; Miguel A. Shingu-Vazquez; Xiaoling Yu; Deepa Waghra ..., Proceedings of the National Academy of Sciences current issue, 2014

αβ T-cell receptor (TCR) activation plays a crucial role for T-cell function. However, the TCR itself does not possess signaling domains. Instead, the TCR is noncovalently coupled to a conserved multisubunit signaling apparatus, the CD3 complex, that comprises the CD3εγ, CD3εδ, and CD3ζζ dimers. ...

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Functionally distinct ERAP1 allotype combinations distinguish individuals with Ankylosing Spondylitis [Immunology and Inflammation]

09-12-2014 | Emma Reeves; Alexandra Colebatch-Bourn; Tim Elliott; Christopher J. Edwards; Edward James, Proceedings of the National Academy of Sciences current issue, 2014

For more than 40 y, expression of HLA-B27 has been strongly associated with the chronic inflammatory disease Ankylosing Spondylitis (AS); however, the mechanisms underlying this association are still unknown. Single nucleotide polymorphisms within the aminopeptidase endoplasmic reticulum ...

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Optimal T-cell receptor affinity for inducing autoimmunity [Immunology and Inflammation]

02-12-2014 | Sabrina Koehli; Dieter Naeher; Virginie Galati-Fournier; Dietmar Zehn; Ed Palmer, Proceedings of the National Academy of Sciences current issue, 2014

T-cell receptor affinity for self-antigen has an important role in establishing self-tolerance. Three transgenic mouse strains expressing antigens of variable affinity for the OVA transgenic-I T-cell receptor were generated to address how TCR affinity affects the efficiency of negative selection, ...

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Going viral and the fatal vulnerability of neurons from immunity, not from infection [Immunology and Inflammation]

02-12-2014 | Lawrence Steinman, Proceedings of the National Academy of Sciences current issue, 2014

Clinicians are often faced with life and death choices in treating patients with viral infections. Often, consideration focuses on viral eradication with antiviral therapies, akin to bacterial antibiotics or to immune-based strategies, involving either active immunization or passive immunization ...

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Caspase-1 autoproteolysis is differentially required for NLRP1b and NLRP3 inflammasome function [Immunology and Inflammation]

02-12-2014 | Baptiste Guey; Mélanie Bodnar; Serge N. Manié; Aubry Tardivel; Virginie Petrilli, Proceedings of the National Academy of Sciences current issue, 2014

Inflammasomes are caspase-1–activating multiprotein complexes. The mouse nucleotide-binding domain and leucine rich repeat pyrin containing 1b (NLRP1b) inflammasome was identified as the sensor of Bacillus anthracis lethal toxin (LT) in mouse macrophages from sensitive strains such as BALB/c. ...

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Basophil-mediated protection against gastrointestinal helminths requires IgE-induced cytokine secretion [Immunology and Inflammation]

02-12-2014 | Christian Schwartz; Adriana Turqueti-Neves; Susanne Hartmann; Philipp Yu; Falk Nimmerjahn; David Voehringer, Proceedings of the National Academy of Sciences current issue, 2014

Basophils orchestrate protection against reinfections with gastrointestinal helminths and ticks, but the underlying mechanisms remain elusive. We investigated the role of Fc receptors on basophils, the antibody isotypes IgG1 and IgE, and basophil-derived IL-4/IL-13 during challenge infections ...

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APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination [Immunology and Inflammation]

02-12-2014 | Jianliang Xu; Afzal Husain; Wenjun Hu; Tasuku Honjo; Maki Kobayashi, Proceedings of the National Academy of Sciences current issue, 2014

Activation-induced cytidine deaminase (AID) is essential for antibody diversification, namely somatic hypermutation (SHM) and class switch recombination (CSR). The deficiency of apurinic/apyrimidinic endonuclease 1 (Ape1) in CH12F3-2A B cells reduces CSR to ∼20% of wild-type cells, whereas the ...

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Correction for Yuan et al., Pivotal role of NOD2 in inflammatory processes affecting atherosclerosis and periodontal bone loss [Correction]

25-11-2014 | Proceedings of the National Academy of Sciences current issue, 2014

IMMUNOLOGY Correction for “Pivotal role of NOD2 in inflammatory processes affecting atherosclerosis and periodontal bone loss,” by Huaiping Yuan, Sami Zelka, Marina Burkatovskaya, Rohit Gupte, Susan E. Leeman, and Salomon Amar, which appeared in issue 52, December 24, 2013, of Proc Natl Acad Sci ...

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Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex [Immunology and Inflammation]

18-11-2014 | Gregory J. Fredericks; FuKun W. Hoffmann; Aaron H. Rose; Hanna J. Osterheld; Franz M. Hess; Frederic Mercier; Peter ..., Proceedings of the National Academy of Sciences current issue, 2014

Calcium (Ca2+) is a secondary messenger in cells and Ca2+ flux initiated from endoplasmic reticulum (ER) stores via inositol 1,4,5-triphosphate (IP3) binding to the IP3 receptor (IP3R) is particularly important for the activation and function of immune cells. Previous studies demonstrated that ...

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Single-cell mass cytometry of TCR signaling: Amplification of small initial differences results in low ERK activation in NOD mice [Immunology and Inflammation]

18-11-2014 | Michael Mingueneau; Smita Krishnaswamy; Matthew H. Spitzer; Sean C. Bendall; Erica L. Stone; Stephen M. Hedrick; Dan ..., Proceedings of the National Academy of Sciences current issue, 2014

Signaling from the T-cell receptor (TCR) conditions T-cell differentiation and activation, requiring exquisite sensitivity and discrimination. Using mass cytometry, a high-dimensional technique that can probe multiple signaling nodes at the single-cell level, we interrogate TCR signaling dynamics ...

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