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531 Newest Publications in proceedings of the national academy of sciences current issue

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Disregulated expression of the transcription factor ThPOK during T-cell development leads to high incidence of T-cell lymphomas [Immunology and Inflammation]

23-Jun-2015 | Hyung-Ok Lee; Xiao He; Jayati Mookerjee-Basu; Dai Zhongping; Xiang Hua; Emmanuelle Nicolas; Maria Luisa Sulis; Adolf ..., Proceedings of the National Academy of Sciences current issue, 2015

The transcription factor T-helper-inducing POZ/Krueppel-like factor (ThPOK, encoded by the Zbtb7b gene) plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. Here we show that mice expressing a constitutive T-cell–specific ThPOK ...

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Inflammation negatively regulates FOXP3 and regulatory T-cell function via DBC1 [Immunology and Inflammation]

23-Jun-2015 | Yayi Gao; Jiayou Tang; Weiqian Chen; Qiang Li; Jia Nie; Fang Lin; Qingsi Wu; Zuojia Chen; Zhimei Gao; Huimin Fan; An ..., Proceedings of the National Academy of Sciences current issue, 2015

Forkhead box P3 (FOXP3)-positive Treg cells are crucial for maintaining immune homeostasis. FOXP3 cooperates with its binding partners to elicit Treg cells’ signature and function, but the molecular mechanisms underlying the modulation of the FOXP3 complex remain unclear. Here we report that ...

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Focusing and sustaining the antitumor CTL effector killer response by agonist anti-CD137 mAb [Immunology and Inflammation]

16-Jun-2015 | Bettina Weigelin; Elixabet Bolaños; Alvaro Teijeira; Ivan Martinez-Forero; Sara Labiano; Arantza Azpilikueta; Aizea ..., Proceedings of the National Academy of Sciences current issue, 2015

Cancer immunotherapy is undergoing significant progress due to recent clinical successes by refined adoptive T-cell transfer and immunostimulatory monoclonal Ab (mAbs). B16F10-derived OVA-expressing mouse melanomas resist curative immunotherapy with either adoptive transfer of activated anti-OVA ...

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Human HLA-G+ extravillous trophoblasts: Immune-activating cells that interact with decidual leukocytes [Immunology and Inflammation]

09-Jun-2015 | Tamara Tilburgs; Ângela C. Crespo; Anita van der Zwan; Basya Rybalov; Towfique Raj; Barbara Stranger; Lucy Gardner; ..., Proceedings of the National Academy of Sciences current issue, 2015

Invading human leukocyte antigen-G+ (HLA‐G+) extravillous trophoblasts (EVT) are rare cells that are believed to play a key role in the prevention of a maternal immune attack on foreign fetal tissues. Here highly purified HLA‐G+ EVT and HLA‐G− villous trophoblasts (VT) were isolated. Culture on ...

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pH-dependent recognition of apoptotic and necrotic cells by the human dendritic cell receptor DEC205 [Immunology and Inflammation]

09-Jun-2015 | Longxing Cao; Xiangyi Shi; Haishuang Chang; Qinfen Zhang; Yongning He, Proceedings of the National Academy of Sciences current issue, 2015

Dendritic cells play important roles in regulating innate and adaptive immune responses. DEC205 (CD205) is one of the major endocytotic receptors on dendritic cells and has been widely used for vaccine generation against viruses and tumors. However, little is known about its structure and ...

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Circadian control of innate immunity in macrophages by miR-155 targeting Bmal1 [Immunology and Inflammation]

09-Jun-2015 | Anne M. Curtis; Caio T. Fagundes; Guangrui Yang; Eva M. Palsson-McDermott; Paulina Wochal; Anne F. McGettrick; Niamh ..., Proceedings of the National Academy of Sciences current issue, 2015

The response to an innate immune challenge is conditioned by the time of day, but the molecular basis for this remains unclear. In myeloid cells, there is a temporal regulation to induction by lipopolysaccharide (LPS) of the proinflammatory microRNA miR-155 that correlates inversely with levels ...

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Sialyl Lewis x (CD15s) identifies highly differentiated and most suppressive FOXP3high regulatory T cells in humans [Immunology and Inflammation]

09-Jun-2015 | Makoto Miyara; Driss Chader; Edouard Sage; Daisuke Sugiyama; Hiroyoshi Nishikawa; Diane Bouvry; Laetitia Claër; Ravi ..., Proceedings of the National Academy of Sciences current issue, 2015

CD4+ regulatory T (Treg) cells expressing CD25 and the transcription factor forkhead box P3 (FOXP3) are indispensable for immunological self-tolerance and homeostasis. FOXP3+CD25+CD4+ T cells in humans, however, are heterogeneous in function and differentiation status, including suppressive or ...

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AMCase is a crucial regulator of type 2 immune responses to inhaled house dust mites [Immunology and Inflammation]

02-Jun-2015 | Lark Kyun Kim; Rimpei Morita; Yasushi Kobayashi; Stephanie C. Eisenbarth; Chun Geun Lee; Jack Elias; Elizabeth E. Ey ..., Proceedings of the National Academy of Sciences current issue, 2015

Chitinases are enzymes that cleave chitin, a component of the exoskeleton of many organisms including the house dust mite (HDM). Here we show that knockin mice expressing an enzymatically inactive acidic mammalian chitinase (AMCase), the dominant true chitinase in mouse lung, showed enhanced type ...

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Th17 cells give rise to Th1 cells that are required for the pathogenesis of colitis [Immunology and Inflammation]

02-Jun-2015 | Stacey N. Harbour; Craig L. Maynard; Carlene L. Zindl; Trenton R. Schoeb; Casey T. Weaver, Proceedings of the National Academy of Sciences current issue, 2015

Th17 cells reactive to the enteric microbiota are central to the pathogenesis of certain types of inflammatory bowel disease. However, Th17 cells display substantial developmental plasticity, such that some progeny of Th17 cell precursors retain a predominantly IL-17A+ phenotype, whereas others ...

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Immune-checkpoint proteins VISTA and PD-1 nonredundantly regulate murine T-cell responses [Immunology and Inflammation]

26-May-2015 | Jun Liu; Ying Yuan; Wenna Chen; Juan Putra; Arief A. Suriawinata; Austin D. Schenk; Halli E. Miller; Indira Guleria; ..., Proceedings of the National Academy of Sciences current issue, 2015

V-domain immunoglobulin suppressor of T-cell activation (VISTA) is a negative immune-checkpoint protein that suppresses T-cell responses. To determine whether VISTA synergizes with another immune-checkpoint, programmed death 1 (PD-1), this study characterizes the immune responses in ...

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