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520 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

Precision-guided antimicrobial peptide as a targeted modulator of human microbial ecology [Microbiology]

16-Jun-2015 | Lihong Guo; Jeffrey S. McLean; Youngik Yang; Randal Eckert; Christopher W. Kaplan; Pierre Kyme; Omid Sheikh; Brian V ..., Proceedings of the National Academy of Sciences current issue, 2015

One major challenge to studying human microbiome and its associated diseases is the lack of effective tools to achieve targeted modulation of individual species and study its ecological function within multispecies communities. Here, we show that C16G2, a specifically targeted antimicrobial ...

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A tyrosine-based motif in the HIV-1 envelope glycoprotein tail mediates cell-type- and Rab11-FIP1C-dependent incorporation into virions [Microbiology]

16-Jun-2015 | Mingli Qi; Hin Chu; Xuemin Chen; Junghwa Choi; Xiaoyun Wen; Jason Hammonds; Lingmei Ding; Eric Hunter; Paul Spearman, Proceedings of the National Academy of Sciences current issue, 2015

Lentiviruses such as HIV-1 encode envelope glycoproteins (Env) with long cytoplasmic tails (CTs) that include motifs mediating interactions with host-cell–trafficking factors. We demonstrated recently that Rab11-family interacting protein 1C (FIP1C) is required for CT-dependent incorporation of ...

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Two-level inhibition of galK expression by Spot 42: Degradation of mRNA mK2 and enhanced transcription termination before the galK gene [Microbiology]

16-Jun-2015 | Xun Wang; Sang Chun Ji; Heung Jin Jeon; Yonho Lee; Heon M. Lim, Proceedings of the National Academy of Sciences current issue, 2015

The Escherichia coli gal operon has the structure Pgal-galE-galT-galK-galM. During early log growth, a gradient in gene expression, named type 2 polarity, is established, as follows: galE > galT > galK > galM. However, during late-log growth, type 1 polarity is established in which galK is ...

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Pheromone killing of multidrug-resistant Enterococcus faecalis V583 by native commensal strains [Microbiology]

09-Jun-2015 | Michael S. Gilmore; Marcus Rauch; Matthew M. Ramsey; Paul R. Himes; Sriram Varahan; Janet M. Manson; Francois Lebret ..., Proceedings of the National Academy of Sciences current issue, 2015

Multidrug-resistant Enterococcus faecalis possess numerous mobile elements that encode virulence and antibiotic resistance traits as well as new metabolic pathways, often constituting over one-quarter of the genome. It was of interest to determine how this large accretion of mobile elements ...

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Structure of a bacterial toxin-activating acyltransferase [Microbiology]

09-Jun-2015 | Nicholas P. Greene; Allister Crow; Colin Hughes; Vassilis Koronakis, Proceedings of the National Academy of Sciences current issue, 2015

Secreted pore-forming toxins of pathogenic Gram-negative bacteria such as Escherichia coli hemolysin (HlyA) insert into host–cell membranes to subvert signal transduction and induce apoptosis and cell lysis. Unusually, these toxins are synthesized in an inactive form that requires ...

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In vitro model for lytic replication, latency, and transformation of an oncogenic alphaherpesvirus [Microbiology]

09-Jun-2015 | Julia Schermuly; Annachiara Greco; Sonja Härtle; Nikolaus Osterrieder; Benedikt B. Kaufer; Bernd Kaspers, Proceedings of the National Academy of Sciences current issue, 2015

Marek’s disease virus (MDV) is an alphaherpesvirus that causes deadly T-cell lymphomas in chickens and serves as a natural small animal model for virus-induced tumor formation. In vivo, MDV lytically replicates in B cells that transfer the virus to T cells in which the virus establishes latency. ...

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Elucidating microbial codes to distinguish individuals [Microbiology]

02-Jun-2015 | Allyson L. Byrd; Julia A. Segre, Proceedings of the National Academy of Sciences current issue, 2015

Studies of the human microbiome have revealed that both site specificity and individuality play a role in shaping the microbial communities of healthy individuals (1). Longitudinal studies have determined that bacterial strains remain stable over time (2, 3), suggesting that microbial signatures ...

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Cell rejuvenation and social behaviors promoted by LPS exchange in myxobacteria [Microbiology]

02-Jun-2015 | Christopher Vassallo; Darshankumar T. Pathak; Pengbo Cao; David M. Zuckerman; Egbert Hoiczyk; Daniel Wall, Proceedings of the National Academy of Sciences current issue, 2015

Bacterial cells in their native environments must cope with factors that compromise the integrity of the cell. The mechanisms of coping with damage in a social or multicellular context are poorly understood. Here we investigated how a model social bacterium, Myxococcus xanthus, approaches this ...

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Identifying personal microbiomes using metagenomic codes [Microbiology]

02-Jun-2015 | Eric A. Franzosa; Katherine Huang; James F. Meadow; Dirk Gevers; Katherine P. Lemon; Brendan J. M. Bohannan; Curtis ..., Proceedings of the National Academy of Sciences current issue, 2015

Community composition within the human microbiome varies across individuals, but it remains unknown if this variation is sufficient to uniquely identify individuals within large populations or stable enough to identify them over time. We investigated this by developing a hitting set-based coding ...

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Malaria genotyping for epidemiologic surveillance [Microbiology]

02-Jun-2015 | Bryan Greenhouse; David L. Smith, Proceedings of the National Academy of Sciences current issue, 2015

Malaria control and elimination have, for more than a century, relied on traditional surveillance methods: catching mosquitoes or examining blood slides under a light microscope. Recent technological advances have started to change the game, including high-quality rapid diagnostic tests for ...

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