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436 Newest Publications in proceedings of the national academy of sciences current issue

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Chlorovirus ATCV-1 is part of the human oropharyngeal virome and is associated with changes in cognitive functions in humans and mice [Microbiology]

11-11-2014 | Robert H. Yolken; Lorraine Jones-Brando; David D. Dunigan; Geetha Kannan; Faith Dickerson; Emily Severance; Sarven S ..., Proceedings of the National Academy of Sciences current issue, 2014

Chloroviruses (family Phycodnaviridae) are large DNA viruses known to infect certain eukaryotic green algae and have not been previously shown to infect humans or to be part of the human virome. We unexpectedly found sequences homologous to the chlorovirus Acanthocystis turfacea chlorella virus 1 ...

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Solution structures of Mengovirus Leader protein, its phosphorylated derivatives, and in complex with nuclear transport regulatory protein, RanGTPase [Microbiology]

04-11-2014 | Valjean R. Bacot-Davis; Jessica J. Ciomperlik; Holly A. Basta; Claudia C. Cornilescu; Ann C. Palmenberg, Proceedings of the National Academy of Sciences current issue, 2014

Cardiovirus Leader (L) proteins induce potent antihost inhibition of active cellular nucleocytoplasmic trafficking by triggering aberrant hyperphosphorylation of nuclear pore proteins (Nup). To achieve this, L binds protein RanGTPase (Ran), a key trafficking regulator, and diverts it into ...

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Elucidating marine virus ecology through a unified heartbeat [Microbiology]

04-11-2014 | Kay D. Bidle, Proceedings of the National Academy of Sciences current issue, 2014

A challenge to virus ecology Marine environments teem with viruses. They are not only the most abundant (109 to 1010 virus l−1) and diverse biological entities in the oceans, but their parasitic lifestyles collectively turn over >25% of global photosynthetically fixed carbon through cell lysis, ...

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Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein [Microbiology]

21-10-2014 | Jean Kaoru Millet; Gary R. Whittaker, Proceedings of the National Academy of Sciences current issue, 2014

Middle East respiratory syndrome coronavirus (MERS-CoV) is a newly identified betacoronavirus causing high morbidity and mortality in humans. The coronavirus spike (S) protein is the main determinant of viral entry, and although it was previously shown that MERS-CoV S can be activated by various ...

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Bloom of resident antibiotic-resistant bacteria in soil following manure fertilization [Microbiology]

21-10-2014 | Nikolina Udikovic-Kolic; Fabienne Wichmann; Nichole A. Broderick; Jo Handelsman, Proceedings of the National Academy of Sciences current issue, 2014

The increasing prevalence of antibiotic-resistant bacteria is a global threat to public health. Agricultural use of antibiotics is believed to contribute to the spread of antibiotic resistance, but the mechanisms by which many agricultural practices influence resistance remain obscure. Although ...

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Structural studies on the authentic mumps virus nucleocapsid showing uncoiling by the phosphoprotein [Microbiology]

21-10-2014 | Robert Cox; Adrian Pickar; Shihong Qiu; Jun Tsao; Cynthia Rodenburg; Terje Dokland; Andrew Elson; Biao He; Ming Luo, Proceedings of the National Academy of Sciences current issue, 2014

Mumps virus (MuV) is a highly contagious pathogen, and despite extensive vaccination campaigns, outbreaks continue to occur worldwide. The virus has a negative-sense, single-stranded RNA genome that is encapsidated by the nucleocapsid protein (N) to form the nucleocapsid (NC). NC serves as the ...

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Retroviral envelope syncytin capture in an ancestrally diverged mammalian clade for placentation in the primitive Afrotherian tenrecs [Microbiology]

14-10-2014 | Guillaume Cornelis; Cécile Vernochet; Sébastien Malicorne; Sylvie Souquere; Athanasia C. Tzika; Steven M. Goodman; F ..., Proceedings of the National Academy of Sciences current issue, 2014

Syncytins are fusogenic envelope (env) genes of retroviral origin that have been captured for a function in placentation. Syncytins have been identified in Euarchontoglires (primates, rodents, Leporidae) and Laurasiatheria (Carnivora, ruminants) placental mammals. Here, we searched for similar ...

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Bacterial quorum sensing and metabolic slowing in a cooperative population [Microbiology]

14-10-2014 | Jae Hyung An; Eunhye Goo; Hongsup Kim; Young-Su Seo; Ingyu Hwang, Proceedings of the National Academy of Sciences current issue, 2014

Acyl-homoserine lactone (AHL)-mediated quorum sensing (QS) controls the production of numerous intra- and extracellular products across many species of Proteobacteria. Although these cooperative activities are often costly at an individual level, they provide significant benefits to the group. ...

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Novel coding, translation, and gene expression of a replicating covalently closed circular RNA of 220 nt [Microbiology]

07-10-2014 | Mounir Georges AbouHaidar; Srividhya Venkataraman; Ashkan Golshani; Bolin Liu; Tauqeer Ahmad, Proceedings of the National Academy of Sciences current issue, 2014

The highly structured (64% GC) covalently closed circular (CCC) RNA (220 nt) of the virusoid associated with rice yellow mottle virus codes for a 16-kDa highly basic protein using novel modalities for coding, translation, and gene expression. This CCC RNA is the smallest among all known viroids ...

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Noncanonical SMC protein in Mycobacterium smegmatis restricts maintenance of Mycobacterium fortuitum plasmids [Microbiology]

16-09-2014 | Michael W. Panas; Paras Jain; Hui Yang; Shimontini Mitra; Debasis Biswas; Alice Rebecca Wattam; Norman L. Letvin; Wi ..., Proceedings of the National Academy of Sciences current issue, 2014

Research on tuberculosis and leprosy was revolutionized by the development of a plasmid transformation system in the fast-growing surrogate, Mycobacterium smegmatis. This transformation system was made possible by the successful isolation of a M. smegmatis mutant strain mc2155, whose efficient ...

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