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489 Newest Publications in proceedings of the national academy of sciences current issue

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Plant-derived antifungal agent poacic acid targets {beta}-1,3-glucan [Microbiology]

24-Mar-2015 | Jeff S. Piotrowski; Hiroki Okada; Fachuang Lu; Sheena C. Li; Li Hinchman; Ashish Ranjan; Damon L. Smith; Alan J. Hig ..., Proceedings of the National Academy of Sciences current issue, 2015

A rise in resistance to current antifungals necessitates strategies to identify alternative sources of effective fungicides. We report the discovery of poacic acid, a potent antifungal compound found in lignocellulosic hydrolysates of grasses. Chemical genomics using Saccharomyces cerevisiae ...

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HIV-1 replication capacity: Setting the pace of disease [Microbiology]

24-Mar-2015 | Carolyn Williamson; Ronald Swanstrom, Proceedings of the National Academy of Sciences current issue, 2015

In PNAS, Claiborne et al. (1) use a measure of HIV-1 fitness to explore its role in events early after infection that set the course for long-term disease progression. Individuals with acute HIV-1 infection have very high viral loads, often reaching tens of million virus particles per milliliter. ...

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Origin of the HIV-1 group O epidemic in western lowland gorillas [Microbiology]

17-Mar-2015 | Mirela D’arc; Ahidjo Ayouba; Amandine Esteban; Gerald H. Learn; Vanina Boué; Florian Liegeois; Lucie Etienne; Nikki ..., Proceedings of the National Academy of Sciences current issue, 2015

HIV-1, the cause of AIDS, is composed of four phylogenetic lineages, groups M, N, O, and P, each of which resulted from an independent cross-species transmission event of simian immunodeficiency viruses (SIVs) infecting African apes. Although groups M and N have been traced to geographically ...

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Disentangling mechanisms that mediate the balance between stochastic and deterministic processes in microbial succession [Microbiology]

17-Mar-2015 | Francisco Dini-Andreote; James C. Stegen; Jan Dirk van Elsas; Joana Falcão Salles, Proceedings of the National Academy of Sciences current issue, 2015

Ecological succession and the balance between stochastic and deterministic processes are two major themes within microbial ecology, but these conceptual domains have mostly developed independent of each other. Here we provide a framework that integrates shifts in community assembly processes with ...

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Retroviral vectors elevate coexpressed protein levels in trans through cap-dependent translation [Microbiology]

17-Mar-2015 | Yongqiang Gou; Hyewon Byun; Adam E. Zook; Gurvani B. Singh; Andrea K. Nash; Mary M. Lozano; Jaquelin P. Dudley, Proceedings of the National Academy of Sciences current issue, 2015

Retroviruses cause immunodeficiency and cancer but also are used as vectors for the expression of heterologous genes. Nevertheless, optimal translation of introduced genes often is not achieved. Here we show that transfection into mammalian cells of lentiviral or gammaretroviral vectors, ...

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AcrB drug-binding pocket substitution confers clinically relevant resistance and altered substrate specificity [Microbiology]

17-Mar-2015 | Jessica M. A. Blair; Vassiliy N. Bavro; Vito Ricci; Niraj Modi; Pierpaolo Cacciotto; Ulrich Kleinekathӧfer; Paolo Ru ..., Proceedings of the National Academy of Sciences current issue, 2015

The incidence of multidrug-resistant bacterial infections is increasing globally and the need to understand the underlying mechanisms is paramount to discover new therapeutics. The efflux pumps of Gram-negative bacteria have a broad substrate range and transport antibiotics out of the bacterium, ...

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Rapid selection against arbovirus-induced apoptosis during infection of a mosquito vector [Microbiology]

10-Mar-2015 | Katelyn O’Neill; Bradley J. S. C. Olson; Ning Huang; Dave Unis; Rollie J. Clem, Proceedings of the National Academy of Sciences current issue, 2015

Millions of people are infected each year by arboviruses (arthropod-borne viruses) such as chikungunya, dengue, and West Nile viruses, yet for reasons that are largely unknown, only a relatively small number of mosquito species are able to transmit arboviruses. Understanding the complex factors ...

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MinD-like ATPase FlhG effects location and number of bacterial flagella during C-ring assembly [Microbiology]

10-Mar-2015 | Jan S. Schuhmacher; Florian Rossmann; Felix Dempwolff; Carina Knauer; Florian Altegoer; Wieland Steinchen; Anja K. D ..., Proceedings of the National Academy of Sciences current issue, 2015

The number and location of flagella, bacterial organelles of locomotion, are species specific and appear in regular patterns that represent one of the earliest taxonomic criteria in microbiology. However, the mechanisms that reproducibly establish these patterns during each round of cell division ...

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Dysregulation of Escherichia coli {alpha}-hemolysin expression alters the course of acute and persistent urinary tract infection [Microbiology]

24-Feb-2015 | Kanna Nagamatsu; Thomas J. Hannan; Randi L. Guest; Maria Kostakioti; Maria Hadjifrangiskou; Jana Binkley; Karen Dods ..., Proceedings of the National Academy of Sciences current issue, 2015

Urinary tract infections (UTIs) are among the most common bacterial infections, causing considerable morbidity in females. Infection is highly recurrent despite appropriate antibiotic treatment. Uropathogenic Escherichia coli (UPEC), the most common causative agent of UTIs, invades bladder ...

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N2 gas is an effective fertilizer for bioethanol production by Zymomonas mobilis [Microbiology]

17-Feb-2015 | Timothy A. Kremer; Breah LaSarre; Amanda L. Posto; James B. McKinlay, Proceedings of the National Academy of Sciences current issue, 2015

A nascent cellulosic ethanol industry is struggling to become cost-competitive against corn ethanol and gasoline. Millions of dollars are spent on nitrogen supplements to make up for the low nitrogen content of the cellulosic feedstock. Here we show for the first time to our knowledge that the ...

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