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535 Newest Publications in proceedings of the national academy of sciences current issue

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A novel mycovirus from Aspergillus fumigatus contains four unique dsRNAs as its genome and is infectious as dsRNA [Microbiology]

21-Jul-2015 | Lakkhana Kanhayuwa; Ioly Kotta-Loizou; Selin Özkan; A. Patrick Gunning; Robert H. A. Coutts, Proceedings of the National Academy of Sciences current issue, 2015

We report the discovery and characterization of a double-stranded RNA (dsRNA) mycovirus isolated from the human pathogenic fungus Aspergillus fumigatus, Aspergillus fumigatus tetramycovirus-1 (AfuTmV-1), which reveals several unique features not found previously in positive-strand RNA viruses, ...

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Vacuolar ATPase depletion affects mitochondrial ATPase function, kinetoplast dependency, and drug sensitivity in trypanosomes [Microbiology]

21-Jul-2015 | Nicola Baker; Graham Hamilton; Jonathan M. Wilkes; Sebastian Hutchinson; Michael P. Barrett; David Horn, Proceedings of the National Academy of Sciences current issue, 2015

Kinetoplastid parasites cause lethal diseases in humans and animals. The kinetoplast itself contains the mitochondrial genome, comprising a huge, complex DNA network that is also an important drug target. Isometamidium, for example, is a key veterinary drug that accumulates in the kinetoplast in ...

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Identification of divergent type VI secretion effectors using a conserved chaperone domain [Microbiology]

21-Jul-2015 | Xiaoye Liang; Richard Moore; Mike Wilton; Megan J. Q. Wong; Linh Lam; Tao G. Dong, Proceedings of the National Academy of Sciences current issue, 2015

The type VI secretion system (T6SS) is a lethal weapon used by many bacteria to kill eukaryotic predators or prokaryotic competitors. Killing by the T6SS results from repetitive delivery of toxic effectors. Despite their importance in dictating bacterial fitness, systematic prediction of T6SS ...

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Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection [Microbiology]

14-Jul-2015 | Kristen E. Pascal; Christopher M. Coleman; Alejandro O. Mujica; Vishal Kamat; Ashok Badithe; Jeanette Fairhurst; Cha ..., Proceedings of the National Academy of Sciences current issue, 2015

Traditional approaches to antimicrobial drug development are poorly suited to combatting the emergence of novel pathogens. Additionally, the lack of small animal models for these infections hinders the in vivo testing of potential therapeutics. Here we demonstrate the use of the VelocImmune ...

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Structural asymmetry in a conserved signaling system that regulates division, replication, and virulence of an intracellular pathogen [Microbiology]

14-Jul-2015 | Jonathan W. Willett; Julien Herrou; Ariane Briegel; Grant Rotskoff; Sean Crosson, Proceedings of the National Academy of Sciences current issue, 2015

We have functionally and structurally defined an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival of the global zoonotic pathogen Brucella abortus. Our study delineates phosphoryl transfer through this molecular pathway, ...

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Genomic analysis of diversity, population structure, virulence, and antimicrobial resistance in Klebsiella pneumoniae, an urgent threat to public health [Microbiology]

07-Jul-2015 | Kathryn E. Holt; Heiman Wertheim; Ruth N. Zadoks; Stephen Baker; Chris A. Whitehouse; David Dance; Adam Jenney; Thom ..., Proceedings of the National Academy of Sciences current issue, 2015

Klebsiella pneumoniae is now recognized as an urgent threat to human health because of the emergence of multidrug-resistant strains associated with hospital outbreaks and hypervirulent strains associated with severe community-acquired infections. K. pneumoniae is ubiquitous in the environment and ...

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A self-lysis pathway that enhances the virulence of a pathogenic bacterium [Microbiology]

07-Jul-2015 | Kirsty A. McFarland; Emily L. Dolben; Michele LeRoux; Tracy K. Kambara; Kathryn M. Ramsey; Robin L. Kirkpatrick; Jos ..., Proceedings of the National Academy of Sciences current issue, 2015

In mammalian cells, programmed cell death (PCD) plays important roles in development, in the removal of damaged cells, and in fighting bacterial infections. Although widespread among multicellular organisms, there are relatively few documented instances of PCD in bacteria. Here we describe a ...

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Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo [Microbiology]

07-Jul-2015 | Katja Spiess; Mads G. Jeppesen; Mikkel Malmgaard-Clausen; Karen Krzywkowski; Kalpana Dulal; Tong Cheng; Gertrud M. H ..., Proceedings of the National Academy of Sciences current issue, 2015

The use of receptor–ligand interactions to direct toxins to kill diseased cells selectively has shown considerable promise for treatment of a number of cancers and, more recently, autoimmune disease. Here we move the fusion toxin protein (FTP) technology beyond cancer/autoimmune therapeutics to ...

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Correction to Supporting Information for Perez-Mendoza et al., Novel mixed-linkage {beta}-glucan activated by c-di-GMP in Sinorhizobium meliloti [SI Corrections]

07-Jul-2015 | Proceedings of the National Academy of Sciences current issue, 2015

MICROBIOLOGY Correction to Supporting Information for “Novel mixed-linkage β-glucan activated by c-di-GMP in Sinorhizobium meliloti,” by Daniel Pérez-Mendoza, Miguel Ángel Rodríguez-Carvajal, Lorena Romero-Jiménez, Gabriela de Araujo Farias, Javier Lloret, María Trinidad Gallegos, and Juan ...

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Three cyanobacteriochromes work together to form a light color-sensitive input system for c-di-GMP signaling of cell aggregation [Microbiology]

30-Jun-2015 | Gen Enomoto; Ni-Ni-Win; Rei Narikawa; Masahiko Ikeuchi, Proceedings of the National Academy of Sciences current issue, 2015

Cyanobacteriochromes (CBCRs) are cyanobacterial photoreceptors that have diverse spectral properties and domain compositions. Although large numbers of CBCR genes exist in cyanobacterial genomes, no studies have assessed whether multiple CBCRs work together. We recently showed that the ...

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