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546 Newest Publications in proceedings of the national academy of sciences current issue

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The opportunistic marine pathogen Vibrio parahaemolyticus becomes virulent by acquiring a plasmid that expresses a deadly toxin [Microbiology]

25-Aug-2015 | Chung-Te Lee; I-Tung Chen; Yi-Ting Yang; Tzu-Ping Ko; Yun-Tzu Huang; Jiun-Yan Huang; Ming-Fen Huang; Shin-Jen Lin; C ..., Proceedings of the National Academy of Sciences current issue, 2015

Acute hepatopancreatic necrosis disease (AHPND) is a severe, newly emergent penaeid shrimp disease caused by Vibrio parahaemolyticus that has already led to tremendous losses in the cultured shrimp industry. Until now, its disease-causing mechanism has remained unclear. Here we show that an ...

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Anaerobic biosynthesis of the lower ligand of vitamin B12 [Microbiology]

25-Aug-2015 | Amrita B. Hazra; Andrew W. Han; Angad P. Mehta; Kenny C. Mok; Vadim Osadchiy; Tadhg P. Begley; Michiko E. Taga, Proceedings of the National Academy of Sciences current issue, 2015

Vitamin B12 (cobalamin) is required by humans and other organisms for diverse metabolic processes, although only a subset of prokaryotes is capable of synthesizing B12 and other cobamide cofactors. The complete aerobic and anaerobic pathways for the de novo biosynthesis of B12 are known, with the ...

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In situ proteolysis of the Vibrio cholerae matrix protein RbmA promotes biofilm recruitment [Microbiology]

18-Aug-2015 | Daniel R. Smith; Manuel Maestre-Reyna; Gloria Lee; Harry Gerard; Andrew H.-J. Wang; Paula I. Watnick, Proceedings of the National Academy of Sciences current issue, 2015

The estuarine gram-negative rod and human diarrheal pathogen Vibrio cholerae synthesizes a VPS exopolysaccharide-dependent biofilm matrix that allows it to form a 3D structure on surfaces. Proteins associated with the matrix include, RbmA, RbmC, and Bap1. RbmA, a protein whose crystallographic ...

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A globally distributed mobile genetic element inhibits natural transformation of Vibrio cholerae [Microbiology]

18-Aug-2015 | Ankur B. Dalia; Kimberley D. Seed; Stephen B. Calderwood; Andrew Camilli, Proceedings of the National Academy of Sciences current issue, 2015

Natural transformation is one mechanism of horizontal gene transfer (HGT) in Vibrio cholerae, the causative agent of cholera. Recently, it was found that V. cholerae isolates from the Haiti outbreak were poorly transformed by this mechanism. Here, we show that an integrating conjugative element ...

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Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus [Microbiology]

18-Aug-2015 | Davide Corti; Jincun Zhao; Mattia Pedotti; Luca Simonelli; Sudhakar Agnihothram; Craig Fett; Blanca Fernandez-Rodrig ..., Proceedings of the National Academy of Sciences current issue, 2015

Middle East Respiratory Syndrome (MERS) is a highly lethal pulmonary infection caused by a previously unidentified coronavirus (CoV), likely transmitted to humans by infected camels. There is no licensed vaccine or antiviral for MERS, therefore new prophylactic and therapeutic strategies to ...

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Delicate coordination of TRIM21's dual activity in virus neutralization and signaling [Microbiology]

11-Aug-2015 | Florian Full; Michaela U. Gack, Proceedings of the National Academy of Sciences current issue, 2015

TRIM21 belongs to the tripartite motif (TRIM) family of ubiquitin E3 ligases. Approximately 100 TRIM proteins exist in humans, and they all share a common domain structure composed of a RING domain that confers the E3 ligase enzymatic activity, one or two B-boxes, and a coiled-coil domain (1). ...

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Sequential ubiquitination and deubiquitination enzymes synchronize the dual sensor and effector functions of TRIM21 [Microbiology]

11-Aug-2015 | Adam J. Fletcher; Donna L. Mallery; Ruth E. Watkinson; Claire F. Dickson; Leo C. James, Proceedings of the National Academy of Sciences current issue, 2015

Tripartite motif (TRIM) 21 is a cytosolic antibody receptor that neutralizes antibody-coated viruses that penetrate the cell and simultaneously activates innate immunity. Here we show that the conjugation of TRIM21 with K63-linked ubiquitin (Ub-63Ub) catalyzed by the sequential activity of ...

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Entner-Doudoroff pathway for sulfoquinovose degradation in Pseudomonas putida SQ1 [Microbiology]

04-Aug-2015 | Ann-Katrin Felux; Dieter Spiteller; Janosch Klebensberger; David Schleheck, Proceedings of the National Academy of Sciences current issue, 2015

Sulfoquinovose (SQ; 6-deoxy-6-sulfoglucose) is the polar head group of the plant sulfolipid SQ-diacylglycerol, and SQ comprises a major proportion of the organosulfur in nature, where it is degraded by bacteria. A first degradation pathway for SQ has been demonstrated recently, a ...

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Modulation of the cGAS-STING DNA sensing pathway by gammaherpesviruses [Microbiology]

04-Aug-2015 | Zhe Ma; Sarah R. Jacobs; John A. West; Charles Stopford; Zhigang Zhang; Zoe Davis; Glen N. Barber; Britt A. Glaunsin ..., Proceedings of the National Academy of Sciences current issue, 2015

Infection of cells with DNA viruses triggers innate immune responses mediated by DNA sensors. cGMP-AMP synthase (cGAS) is a key DNA sensor that produces the cyclic dinucleotide cGMP-AMP (cGAMP) upon activation, which binds to and activates stimulator of interferon genes (STING), leading to IFN ...

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Structural basis and functional analysis of the SARS coronavirus nsp14-nsp10 complex [Microbiology]

28-Jul-2015 | Yuanyuan Ma; Lijie Wu; Neil Shaw; Yan Gao; Jin Wang; Yuna Sun; Zhiyong Lou; Liming Yan; Rongguang Zhang; Zihe Rao, Proceedings of the National Academy of Sciences current issue, 2015

Nonstructural protein 14 (nsp14) of coronaviruses (CoV) is important for viral replication and transcription. The N-terminal exoribonuclease (ExoN) domain plays a proofreading role for prevention of lethal mutagenesis, and the C-terminal domain functions as a (guanine-N7) methyl transferase ...

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