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395 Newest Publications in proceedings of the national academy of sciences current issue

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Correction for Duitman et al., CCAAT/enhancer-binding protein {delta} facilitates bacterial dissemination during pneumococcal pneumonia in a platelet-activating factor receptor-dependent manner [Correction]

10-09-2013 | Proceedings of the National Academy of Sciences current issue, 2013

MICROBIOLOGY Correction for “CCAAT/enhancer-binding protein δ facilitates bacterial dissemination during pneumococcal pneumonia in a platelet-activating factor receptor-dependent manner,” by JanWillem Duitman, Marcel Schouten, Angelique P. Groot, Joost B. Daalhuisen, Sandrine Florquin, Tom van ...

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Complement modulates the cutaneous microbiome and inflammatory milieu [Microbiology]

10-09-2013 | Christel Chehoud; Stavros Rafail; Amanda S. Tyldsley; John T. Seykora; John D. Lambris; Elizabeth A. Grice, Proceedings of the National Academy of Sciences current issue, 2013

The skin is colonized by a plethora of microbes that include commensals and potential pathogens, but it is currently unknown how cutaneous host immune mechanisms influence the composition, diversity, and quantity of the skin microbiota. Here we reveal an interactive role for complement in ...

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Single point mutations in ATP synthase compensate for mitochondrial genome loss in trypanosomes [Microbiology]

03-09-2013 | Samuel Dean; Matthew K. Gould; Caroline E. Dewar; Achim C. Schnaufer, Proceedings of the National Academy of Sciences current issue, 2013

Viability of the tsetse fly-transmitted African trypanosome Trypanosoma brucei depends on maintenance and expression of its kinetoplast (kDNA), the mitochondrial genome of this parasite and a putative target for veterinary and human antitrypanosomatid drugs. However, the closely related animal ...

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Live-cell imaging of Marburg virus-infected cells uncovers actin-dependent transport of nucleocapsids over long distances [Microbiology]

27-08-2013 | Gordian Schudt; Larissa Kolesnikova; Olga Dolnik; Beate Sodeik; Stephan Becker, Proceedings of the National Academy of Sciences current issue, 2013

Transport of large viral nucleocapsids from replication centers to assembly sites requires contributions from the host cytoskeleton via cellular adaptor and motor proteins. For the Marburg and Ebola viruses, related viruses that cause severe hemorrhagic fevers, the mechanism of nucleocapsid ...

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Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation [Microbiology]

27-08-2013 | Jieling Yang; Yue Zhao; Jianjin Shi; Feng Shao, Proceedings of the National Academy of Sciences current issue, 2013

Inflammasome mediated by central nucleotide-binding and oligomerization domain (NOD)-like receptor (NLR) protein is critical for defense against bacterial infection. Here we show that type III secretion system (T3SS) needle proteins from several bacterial pathogens, including Salmonella ...

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Salmonella typhimurium intercepts Escherichia coli signaling to enhance antibiotic tolerance [Microbiology]

27-08-2013 | Nicole M. Vega; Kyle R. Allison; Amanda N. Samuels; Mark S. Klempner; James J. Collins, Proceedings of the National Academy of Sciences current issue, 2013

Bacterial communication plays an important role in many population-based phenotypes and interspecies interactions, including those in host environments. These interspecies interactions may prove critical to some infectious diseases, and it follows that communication between pathogenic bacteria ...

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Cryoelectron tomography reveals the sequential assembly of bacterial flagella in Borrelia burgdorferi [Microbiology]

27-08-2013 | Xiaowei Zhao; Kai Zhang; Tristan Boquoi; Bo Hu; M. A. Motaleb; Kelly A. Miller; Milinda E. James; Nyles W. Charon; M ..., Proceedings of the National Academy of Sciences current issue, 2013

Periplasmic flagella are essential for the distinctive morphology, motility, and infectious life cycle of the Lyme disease spirochete Borrelia burgdorferi. In this study, we genetically trapped intermediates in flagellar assembly and determined the 3D structures of the intermediates to 4-nm ...

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Structure of N-linked oligosaccharides attached to chlorovirus PBCV-1 major capsid protein reveals unusual class of complex N-glycans [Microbiology]

20-08-2013 | Cristina De Castro; Antonio Molinaro; Francesco Piacente; James R. Gurnon; Luisa Sturiale; Angelo Palmigiano; Rosa L ..., Proceedings of the National Academy of Sciences current issue, 2013

The major capsid protein Vp54 from the prototype chlorovirus Paramecium bursaria chlorella virus 1 (PBCV-1) contains four Asn-linked glycans. The structure of the four N-linked oligosaccharides and the type of substitution at each glycosylation site was determined by chemical, spectroscopic, and ...

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An allele of the crm gene blocks cyanobacterial circadian rhythms [Microbiology]

20-08-2013 | Joseph S. Boyd; Juliana R. Bordowitz; Anna C. Bree; Susan S. Golden, Proceedings of the National Academy of Sciences current issue, 2013

The SasA-RpaA two-component system constitutes a key output pathway of the cyanobacterial Kai circadian oscillator. To date, rhythm of phycobilisome associated (rpaA) is the only gene other than kaiA, kaiB, and kaiC, which encode the oscillator itself, whose mutation causes completely arrhythmic ...

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Host-related metabolic cues affect colonization strategies of a root endophyte [Microbiology]

20-08-2013 | Urs Lahrmann; Yi Ding; Aline Banhara; Magnus Rath; Mohammad R. Hajirezaei; Stefanie Döhlemann; Nicolaus von Wirén; M ..., Proceedings of the National Academy of Sciences current issue, 2013

The mechanisms underpinning broad compatibility in root symbiosis are largely unexplored. The generalist root endophyte Piriformospora indica establishes long-lasting interactions with morphologically and biochemically different hosts, stimulating their growth, alleviating salt stress, and ...

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