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599 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

Sensing of latent EBV infection through exosomal transfer of 5'pppRNA [Microbiology]

02-Feb-2016 | S. Rubina Baglio; Monique A. J. van Eijndhoven; Danijela Koppers-Lalic; Jordi Berenguer; Sinéad M. Lougheed; Susan G ..., Proceedings of the National Academy of Sciences current issue, 2016

Complex interactions between DNA herpesviruses and host factors determine the establishment of a life-long asymptomatic latent infection. The lymphotropic Epstein–Barr virus (EBV) seems to avoid recognition by innate sensors despite massive transcription of immunostimulatory small RNAs ...

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Aminoacyl {beta}-naphthylamides as substrates and modulators of AcrB multidrug efflux pump [Microbiology]

02-Feb-2016 | Alfred D. Kinana; Attilio V. Vargiu; Thithiwat May; Hiroshi Nikaido, Proceedings of the National Academy of Sciences current issue, 2016

Efflux pumps of the resistance-nodulation division superfamily, such as AcrB, make a major contribution to multidrug resistance in Gram-negative bacteria. Inhibitors of such pumps would improve the efficacy of antibiotics, and ameliorate the crisis in health care caused by the prevalence of ...

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Structure and stabilization of the Hendra virus F glycoprotein in its prefusion form [Microbiology]

26-Jan-2016 | Joyce J. W. Wong; Reay G. Paterson; Robert A. Lamb; Theodore S. Jardetzky, Proceedings of the National Academy of Sciences current issue, 2016

Hendra virus (HeV) is one of the two prototypical members of the Henipavirus genus of paramyxoviruses, which are designated biosafety level 4 (BSL-4) organisms due to the high mortality rate of Nipah virus (NiV) and HeV in humans. Paramyxovirus cell entry is mediated by the fusion protein, F, in ...

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Cross-talk among flesh-eating Aeromonas hydrophila strains in mixed infection leading to necrotizing fasciitis [Microbiology]

19-Jan-2016 | Duraisamy Ponnusamy; Elena V. Kozlova; Jian Sha; Tatiana E. Erova; Sasha R. Azar; Eric C. Fitts; Michelle L. Kirtley ..., Proceedings of the National Academy of Sciences current issue, 2016

Necrotizing fasciitis (NF) caused by flesh-eating bacteria is associated with high case fatality. In an earlier study, we reported infection of an immunocompetent individual with multiple strains of Aeromonas hydrophila (NF1–NF4), the latter three constituted a clonal group whereas NF1 was ...

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Neutralizing antibody titers against dengue virus correlate with protection from symptomatic infection in a longitudinal cohort [Microbiology]

19-Jan-2016 | Leah C. Katzelnick; Magelda Montoya; Lionel Gresh; Angel Balmaseda; Eva Harris, Proceedings of the National Academy of Sciences current issue, 2016

The four dengue virus serotypes (DENV1–4) are mosquito-borne flaviviruses that infect ∼390 million people annually; up to 100 million infections are symptomatic, and 500,000 cases progress to severe disease. Exposure to a heterologous DENV serotype, the specific infecting DENV strains, and the ...

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A cell wall damage response mediated by a sensor kinase/response regulator pair enables beta-lactam tolerance [Microbiology]

12-Jan-2016 | Tobias Dörr; Laura Alvarez; Fernanda Delgado; Brigid M. Davis; Felipe Cava; Matthew K. Waldor, Proceedings of the National Academy of Sciences current issue, 2016

The bacterial cell wall is critical for maintenance of cell shape and survival. Following exposure to antibiotics that target enzymes required for cell wall synthesis, bacteria typically lyse. Although several cell envelope stress response systems have been well described, there is little ...

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Structurally conserved erythrocyte-binding domain in Plasmodium provides a versatile scaffold for alternate receptor engagement [Microbiology]

12-Jan-2016 | Jakub Gruszczyk; Nicholas T. Y. Lim; Alicia Arnott; Wen-Qiang He; Wang Nguitragool; Wanlapa Roobsoong; Yee-Foong Mok ..., Proceedings of the National Academy of Sciences current issue, 2016

Understanding how malaria parasites gain entry into human red blood cells is essential for developing strategies to stop blood stage infection. Plasmodium vivax preferentially invades reticulocytes, which are immature red blood cells. The organism has two erythrocyte-binding protein families: ...

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HIV-1 RNA genome dimerizes on the plasma membrane in the presence of Gag protein [Microbiology]

12-Jan-2016 | Jianbo Chen; Sheikh Abdul Rahman; Olga A. Nikolaitchik; David Grunwald; Luca Sardo; Ryan C. Burdick; Sergey Plisov; ..., Proceedings of the National Academy of Sciences current issue, 2016

Retroviruses package a dimeric genome comprising two copies of the viral RNA. Each RNA contains all of the genetic information for viral replication. Packaging a dimeric genome allows the recovery of genetic information from damaged RNA genomes during DNA synthesis and promotes frequent ...

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Hepatitis C virus utilizes VLDLR as a novel entry pathway [Microbiology]

05-Jan-2016 | Saneyuki Ujino; Hironori Nishitsuji; Takayuki Hishiki; Kazuo Sugiyama; Hiroshi Takaku; Kunitada Shimotohno, Proceedings of the National Academy of Sciences current issue, 2016

Various host factors are involved in the cellular entry of hepatitis C virus (HCV). In addition to the factors previously reported, we discovered that the very-low-density lipoprotein receptor (VLDLR) mediates HCV entry independent of CD81. Culturing Huh7.5 cells under hypoxic conditions ...

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Correction for Du et al., Patterns of accumulation of miRNAs encoded by herpes simplex virus during productive infection, latency, and on reactivation [Correction]

05-Jan-2016 | Proceedings of the National Academy of Sciences current issue, 2016

MICROBIOLOGY Correction for “Patterns of accumulation of miRNAs encoded by herpes simplex virus during productive infection, latency, and on reactivation,” by Te Du, Zhiyuan Han, Grace Zhou, and Bernard Roizman, which appeared in issue 1, January 6, 2015, of Proc Natl Acad Sci USA (112:E49–E55; ...

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