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433 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein [Microbiology]

21-10-2014 | Jean Kaoru Millet; Gary R. Whittaker, Proceedings of the National Academy of Sciences current issue, 2014

Middle East respiratory syndrome coronavirus (MERS-CoV) is a newly identified betacoronavirus causing high morbidity and mortality in humans. The coronavirus spike (S) protein is the main determinant of viral entry, and although it was previously shown that MERS-CoV S can be activated by various ...

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Bloom of resident antibiotic-resistant bacteria in soil following manure fertilization [Microbiology]

21-10-2014 | Nikolina Udikovic-Kolic; Fabienne Wichmann; Nichole A. Broderick; Jo Handelsman, Proceedings of the National Academy of Sciences current issue, 2014

The increasing prevalence of antibiotic-resistant bacteria is a global threat to public health. Agricultural use of antibiotics is believed to contribute to the spread of antibiotic resistance, but the mechanisms by which many agricultural practices influence resistance remain obscure. Although ...

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Structural studies on the authentic mumps virus nucleocapsid showing uncoiling by the phosphoprotein [Microbiology]

21-10-2014 | Robert Cox; Adrian Pickar; Shihong Qiu; Jun Tsao; Cynthia Rodenburg; Terje Dokland; Andrew Elson; Biao He; Ming Luo, Proceedings of the National Academy of Sciences current issue, 2014

Mumps virus (MuV) is a highly contagious pathogen, and despite extensive vaccination campaigns, outbreaks continue to occur worldwide. The virus has a negative-sense, single-stranded RNA genome that is encapsidated by the nucleocapsid protein (N) to form the nucleocapsid (NC). NC serves as the ...

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Retroviral envelope syncytin capture in an ancestrally diverged mammalian clade for placentation in the primitive Afrotherian tenrecs [Microbiology]

14-10-2014 | Guillaume Cornelis; Cécile Vernochet; Sébastien Malicorne; Sylvie Souquere; Athanasia C. Tzika; Steven M. Goodman; F ..., Proceedings of the National Academy of Sciences current issue, 2014

Syncytins are fusogenic envelope (env) genes of retroviral origin that have been captured for a function in placentation. Syncytins have been identified in Euarchontoglires (primates, rodents, Leporidae) and Laurasiatheria (Carnivora, ruminants) placental mammals. Here, we searched for similar ...

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Bacterial quorum sensing and metabolic slowing in a cooperative population [Microbiology]

14-10-2014 | Jae Hyung An; Eunhye Goo; Hongsup Kim; Young-Su Seo; Ingyu Hwang, Proceedings of the National Academy of Sciences current issue, 2014

Acyl-homoserine lactone (AHL)-mediated quorum sensing (QS) controls the production of numerous intra- and extracellular products across many species of Proteobacteria. Although these cooperative activities are often costly at an individual level, they provide significant benefits to the group. ...

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Novel coding, translation, and gene expression of a replicating covalently closed circular RNA of 220 nt [Microbiology]

07-10-2014 | Mounir Georges AbouHaidar; Srividhya Venkataraman; Ashkan Golshani; Bolin Liu; Tauqeer Ahmad, Proceedings of the National Academy of Sciences current issue, 2014

The highly structured (64% GC) covalently closed circular (CCC) RNA (220 nt) of the virusoid associated with rice yellow mottle virus codes for a 16-kDa highly basic protein using novel modalities for coding, translation, and gene expression. This CCC RNA is the smallest among all known viroids ...

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Noncanonical SMC protein in Mycobacterium smegmatis restricts maintenance of Mycobacterium fortuitum plasmids [Microbiology]

16-09-2014 | Michael W. Panas; Paras Jain; Hui Yang; Shimontini Mitra; Debasis Biswas; Alice Rebecca Wattam; Norman L. Letvin; Wi ..., Proceedings of the National Academy of Sciences current issue, 2014

Research on tuberculosis and leprosy was revolutionized by the development of a plasmid transformation system in the fast-growing surrogate, Mycobacterium smegmatis. This transformation system was made possible by the successful isolation of a M. smegmatis mutant strain mc2155, whose efficient ...

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One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities [Microbiology]

16-09-2014 | Lorenzo Subissi; Clara C. Posthuma; Axelle Collet; Jessika C. Zevenhoven-Dobbe; Alexander E. Gorbalenya; Etienne Dec ..., Proceedings of the National Academy of Sciences current issue, 2014

In addition to members causing milder human infections, the Coronaviridae family includes potentially lethal zoonotic agents causing severe acute respiratory syndrome (SARS) and the recently emerged Middle East respiratory syndrome. The ∼30-kb positive-stranded RNA genome of coronaviruses encodes ...

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Conformational change in the periplamic region of the flagellar stator coupled with the assembly around the rotor [Microbiology]

16-09-2014 | Shiwei Zhu; Masato Takao; Na Li; Mayuko Sakuma; Yuuki Nishino; Michio Homma; Seiji Kojima; Katsumi Imada, Proceedings of the National Academy of Sciences current issue, 2014

The torque of the bacterial flagellum is generated by the rotor–stator interaction coupled with the ion flow through the channel in the stator. Anchoring the stator unit to the peptidoglycan layer with proper orientation around the rotor is believed to be essential for smooth rotation of the ...

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Xylella fastidiosa outer membrane vesicles modulate plant colonization by blocking attachment to surfaces [Microbiology]

16-09-2014 | Michael Ionescu; Paulo A. Zaini; Clelia Baccari; Sophia Tran; Aline M. da Silva; Steven E. Lindow, Proceedings of the National Academy of Sciences current issue, 2014

Outer membrane vesicles (OMVs) of Gram-negative bacteria have been studied intensively in recent years, primarily in their role in delivering virulence factors and antigens during pathogenesis. However, the near ubiquity of their production suggests that they may play other roles, such as ...

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