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451 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

Bioalcohol production by a new synthetic route in a hyperthermophilic archaeon [Microbiology]

09-12-2014 | Volker Müller, Proceedings of the National Academy of Sciences current issue, 2014

The still growing demand for bioethanol is currently met by two microbiological processes. The by far most important process is the use of first- (sugar) or second- (lignocellulosic biomass) generation raw materials and yeast as catalysts. Yeasts convert the sugars via glycolysis to pyruvate, ...

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Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex [Microbiology]

09-12-2014 | Devin Sok; Marit J. van Gils; Matthias Pauthner; Jean-Philippe Julien; Karen L. Saye-Francisco; Jessica Hsueh; Bryan ..., Proceedings of the National Academy of Sciences current issue, 2014

Broadly neutralizing antibodies (bnAbs) targeting the trimer apex of HIV envelope are favored candidates for vaccine design and immunotherapy because of their great neutralization breadth and potency. However, methods of isolating bnAbs against this site have been limited by the quaternary nature ...

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The cholesterol-dependent cytolysins pneumolysin and streptolysin O require binding to red blood cell glycans for hemolytic activity [Microbiology]

09-12-2014 | Lucy K. Shewell; Richard M. Harvey; Melanie A. Higgins; Christopher J. Day; Lauren E. Hartley-Tassell; Austen Y. Che ..., Proceedings of the National Academy of Sciences current issue, 2014

The cholesterol-dependent cytolysin (CDC) pneumolysin (Ply) is a key virulence factor of Streptococcus pneumoniae. Membrane cholesterol is required for the cytolytic activity of this toxin, but it is not clear whether cholesterol is the only cellular receptor. Analysis of Ply binding to a glycan ...

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Single gene insertion drives bioalcohol production by a thermophilic archaeon [Microbiology]

09-12-2014 | Mirko Basen; Gerrit J. Schut; Diep M. Nguyen; Gina L. Lipscomb; Robert A. Benn; Cameron J. Prybol; Brian J. Vaccaro; ..., Proceedings of the National Academy of Sciences current issue, 2014

Bioethanol production is achieved by only two metabolic pathways and only at moderate temperatures. Herein a fundamentally different synthetic pathway for bioalcohol production at 70 °C was constructed by insertion of the gene for bacterial alcohol dehydrogenase (AdhA) into the archaeon ...

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Densovirus associated with sea-star wasting disease and mass mortality [Microbiology]

02-12-2014 | Ian Hewson; Jason B. Button; Brent M. Gudenkauf; Benjamin Miner; Alisa L. Newton; Joseph K. Gaydos; Janna Wynne; Cat ..., Proceedings of the National Academy of Sciences current issue, 2014

Populations of at least 20 asteroid species on the Northeast Pacific Coast have recently experienced an extensive outbreak of sea-star (asteroid) wasting disease (SSWD). The disease leads to behavioral changes, lesions, loss of turgor, limb autotomy, and death characterized by rapid degradation ...

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Correction for La Rosa et al., Patterned progression of bacterial populations in the premature infant gut [Correction]

02-12-2014 | Proceedings of the National Academy of Sciences current issue, 2014

MICROBIOLOGY Correction for “Patterned progression of bacterial populations in the premature infant gut,” by Patricio S. La Rosa, Barbara B. Warner, Yanjiao Zhou, George M. Weinstock, Erica Sodergren, Carla M. Hall-Moore, Harold J. Stevens, William E. Bennett, Jr., Nurmohammad Shaikh, Laura A. ...

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Cytoplasmic HIV-1 RNA is mainly transported by diffusion in the presence or absence of Gag protein [Microbiology]

02-12-2014 | Jianbo Chen; David Grunwald; Luca Sardo; Andrea Galli; Sergey Plisov; Olga A. Nikolaitchik; De Chen; Stephen Lockett ..., Proceedings of the National Academy of Sciences current issue, 2014

Full-length HIV-1 RNA plays a central role in viral replication by serving as the mRNA for essential viral proteins and as the genome packaged into infectious virions. Proper RNA trafficking is required for the functions of RNA and its encoded proteins; however, the mechanism by which HIV-1 RNA ...

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Global discovery of colonization determinants in the squid symbiont Vibrio fischeri [Microbiology]

02-12-2014 | John F. Brooks II; Mattias C. Gyllborg; David C. Cronin; Sarah J. Quillin; Celeste A. Mallama; Randi Foxall; Cheryl ..., Proceedings of the National Academy of Sciences current issue, 2014

Animal epithelial tissue becomes reproducibly colonized by specific environmental bacteria. The bacteria (microbiota) perform critical functions for the host’s tissue development, immune system development, and nutrition; yet the processes by which bacterial diversity in the environment is ...

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Complex two-component signaling regulates the general stress response in Alphaproteobacteria [Microbiology]

02-12-2014 | Andreas Kaczmarczyk; Ramon Hochstrasser; Julia A. Vorholt; Anne Francez-Charlot, Proceedings of the National Academy of Sciences current issue, 2014

The general stress response (GSR) in Alphaproteobacteria was recently shown to be controlled by a partner-switching mechanism that is triggered by phosphorylation of the response regulator PhyR. Activation of PhyR ultimately results in release of the alternative extracytoplasmic function sigma ...

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XerD-mediated FtsK-independent integration of TLC{phi} into the Vibrio cholerae genome [Microbiology]

25-11-2014 | Caroline Midonet; Bhabatosh Das; Evelyne Paly; Francois-Xavier Barre, Proceedings of the National Academy of Sciences current issue, 2014

As in most bacteria, topological problems arising from the circularity of the two Vibrio cholerae chromosomes, chrI and chrII, are resolved by the addition of a crossover at a specific site of each chromosome, dif, by two tyrosine recombinases, XerC and XerD. The reaction is under the control of ...

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