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1,064 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

Structural and kinetic analysis of protein-aggregate strains in vivo using binary epitope mapping [Neuroscience]

07-Apr-2015 | Johan Bergh; Per Zetterström; Peter M. Andersen; Thomas Brännström; Karin S. Graffmo; P. Andreas Jonsson; Lisa Lang; ..., Proceedings of the National Academy of Sciences current issue, 2015

Despite considerable progress in uncovering the molecular details of protein aggregation in vitro, the cause and mechanism of protein-aggregation disease remain poorly understood. One reason is that the amount of pathological aggregates in neural tissue is exceedingly low, precluding examination ...

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Candidate ionotropic taste receptors in the Drosophila larva [Neuroscience]

07-Apr-2015 | Shannon Stewart; Tong-Wey Koh; Arpan C. Ghosh; John R. Carlson, Proceedings of the National Academy of Sciences current issue, 2015

We examine in Drosophila a group of ∼35 ionotropic receptors (IRs), the IR20a clade, about which remarkably little is known. Of 28 genes analyzed, GAL4 drivers representing 11 showed expression in the larva. Eight drivers labeled neurons of the pharynx, a taste organ, and three labeled neurons of ...

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Facilitation of fear extinction by novelty depends on dopamine acting on D1-subtype dopamine receptors in hippocampus [Neuroscience]

31-Mar-2015 | Jefferson Menezes; Niége Alves; Sidnei Borges; Rafael Roehrs; Jociane de Carvalho Myskiw; Cristiane Regina Guerino F ..., Proceedings of the National Academy of Sciences current issue, 2015

Extinction is the learned inhibition of retrieval. Recently it was shown that a brief exposure to a novel environment enhances the extinction of contextual fear in rats, an effect explainable by a synaptic tagging-and-capture process. Here we examine whether this also happens with the extinction ...

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Inversion of Sonic hedgehog action on its canonical pathway by electrical activity [Neuroscience]

31-Mar-2015 | Yesser H. Belgacem; Laura N. Borodinsky, Proceedings of the National Academy of Sciences current issue, 2015

Sonic hedgehog (Shh) is a morphogenic protein that operates through the Gli transcription factor-dependent canonical pathway to orchestrate normal development of many tissues. Because aberrant levels of Gli activity lead to a wide spectrum of diseases ranging from neurodevelopmental defects to ...

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Adult hippocampal neural stem and progenitor cells regulate the neurogenic niche by secreting VEGF [Neuroscience]

31-Mar-2015 | Elizabeth D. Kirby; Akela A. Kuwahara; Reanna L. Messer; Tony Wyss-Coray, Proceedings of the National Academy of Sciences current issue, 2015

The adult hippocampus hosts a population of neural stem and progenitor cells (NSPCs) that proliferates throughout the mammalian life span. To date, the new neurons derived from NSPCs have been the primary measure of their functional relevance. However, recent studies show that undifferentiated ...

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Correction for Boschin et al., Essential functions of primate frontopolar cortex in cognition [Correction]

31-Mar-2015 | Proceedings of the National Academy of Sciences current issue, 2015

NEUROSCIENCE Correction for “Essential functions of primate frontopolar cortex in cognition,” by Erica A. Boschin, Carinne Piekema, and Mark J. Buckley, which appeared in issue 9, March 3, 2015, of Proc Natl Acad Sci USA (112:E1020–E1027; first published February 17, 2015; ...

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Correction for Zaslaver et al., Hierarchical sparse coding in the sensory system of Caenorhabditis elegans [Correction]

31-Mar-2015 | Proceedings of the National Academy of Sciences current issue, 2015

NEUROSCIENCE Correction for “Hierarchical sparse coding in the sensory system of Caenorhabditis elegans,” by Alon Zaslaver, Idan Liani, Oshrat Shtangel, Shira Ginzburg, Lisa Yee, and Paul W. Sternberg, which appeared in issue 4, January 27, 2015, of Proc Natl Acad Sci USA (112:1185–1189; first ...

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Cortical network models of impulse firing in the resting and active states predict cortical energetics [Neuroscience]

31-Mar-2015 | Maxwell R. Bennett; Les Farnell; William G. Gibson; Jim Lagopoulos, Proceedings of the National Academy of Sciences current issue, 2015

Measurements of the cortical metabolic rate of glucose oxidation [CMRglc(ox)] have provided a number of interesting and, in some cases, surprising observations. One is the decline in CMRglc(ox) during anesthesia and non-rapid eye movement (NREM) sleep, and another, the inverse relationship ...

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Neuropeptide Y stimulates autophagy in hypothalamic neurons [Neuroscience]

31-Mar-2015 | Célia A. Aveleira; Mariana Botelho; Sara Carmo-Silva; Jorge F. Pascoal; Marisa Ferreira-Marques; Clévio Nóbrega; Luí ..., Proceedings of the National Academy of Sciences current issue, 2015

Aging is characterized by autophagy impairment that contributes to age-related disease aggravation. Moreover, it was described that the hypothalamus is a critical brain area for whole-body aging development and has impact on lifespan. Neuropeptide Y (NPY) is one of the major neuropeptides present ...

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Fast sensory-motor reactions in echolocating bats to sudden changes during the final buzz and prey intercept [Neuroscience]

31-Mar-2015 | Cornelia Geberl; Signe Brinkløv; Lutz Wiegrebe; Annemarie Surlykke, Proceedings of the National Academy of Sciences current issue, 2015

Echolocation is an active sense enabling bats and toothed whales to orient in darkness through echo returns from their ultrasonic signals. Immediately before prey capture, both bats and whales emit a buzz with such high emission rates (≥180 Hz) and overall duration so short that its functional ...

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