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1,173 Newest Publications in proceedings of the national academy of sciences current issue

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MeCP2 regulates the timing of critical period plasticity that shapes functional connectivity in primary visual cortex [Neuroscience]

25-Aug-2015 | Keerthi Krishnan; Bor-Shuen Wang; Jiangteng Lu; Lang Wang; Arianna Maffei; Jianhua Cang; Z. Josh Huang, Proceedings of the National Academy of Sciences current issue, 2015

Mutations in methyl-CpG-binding protein 2 (MeCP2) cause Rett syndrome, an autism spectrum-associated disorder with a host of neurological and sensory symptoms, but the pathogenic mechanisms remain elusive. Neuronal circuits are shaped by experience during critical periods of heightened ...

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Expressing our internal states and understanding those of others [Psychological and Cognitive Sciences]

18-Aug-2015 | Giuseppe Di Cesare; Cinzia Di Dio; Massimo Marchi; Giacomo Rizzolatti, Proceedings of the National Academy of Sciences current issue, 2015

Vitality form is a term that describes the style with which motor actions are performed (e.g., rude, gentle, etc.). They represent one characterizing element of conscious and unconscious bodily communication. Despite their importance in interpersonal behavior, vitality forms have been, until now, ...

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Local generation of multineuronal spike sequences in the hippocampal CA1 region [Neuroscience]

18-Aug-2015 | Eran Stark; Lisa Roux; Ronny Eichler; György Buzsáki, Proceedings of the National Academy of Sciences current issue, 2015

Sequential activity of multineuronal spiking can be observed during theta and high-frequency ripple oscillations in the hippocampal CA1 region and is linked to experience, but the mechanisms underlying such sequences are unknown. We compared multineuronal spiking during theta oscillations, ...

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In vivo imaging of axonal transport of mitochondria in the diseased and aged mammalian CNS [Neuroscience]

18-Aug-2015 | Yuji Takihara; Masaru Inatani; Kei Eto; Toshihiro Inoue; Alexander Kreymerman; Seiji Miyake; Shinji Ueno; Masatoshi ..., Proceedings of the National Academy of Sciences current issue, 2015

The lack of intravital imaging of axonal transport of mitochondria in the mammalian CNS precludes characterization of the dynamics of axonal transport of mitochondria in the diseased and aged mammalian CNS. Glaucoma, the most common neurodegenerative eye disease, is characterized by axon ...

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FXR1P is a GSK3{beta} substrate regulating mood and emotion processing [Neuroscience]

18-Aug-2015 | Thomas Del’Guidice; Camille Latapy; Antonio Rampino; Jivan Khlghatyan; Morgane Lemasson; Barbara Gelao; Tiziana Quar ..., Proceedings of the National Academy of Sciences current issue, 2015

Inhibition of glycogen synthase kinase 3β (GSK3β) is a shared action believed to be involved in the regulation of behavior by psychoactive drugs such as antipsychotics and mood stabilizers. However, little is known about the identity of the substrates through which GSK3β affects behavior. We ...

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GRIP1 is required for homeostatic regulation of AMPAR trafficking [Neuroscience]

11-Aug-2015 | Han L. Tan; Bridget N. Queenan; Richard L. Huganir, Proceedings of the National Academy of Sciences current issue, 2015

Homeostatic plasticity is a negative feedback mechanism that stabilizes neurons during periods of perturbed activity. The best-studied form of homeostatic plasticity in the central nervous system is the scaling of excitatory synapses. Postsynaptic AMPA-type glutamate receptors (AMPARs) can be ...

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Na, K-ATPase {alpha}3 is a death target of Alzheimer patient amyloid-{beta} assembly [Neuroscience]

11-Aug-2015 | Takayuki Ohnishi; Masako Yanazawa; Tomoya Sasahara; Yasuki Kitamura; Hidekazu Hiroaki; Yugo Fukazawa; Isao Kii; Taka ..., Proceedings of the National Academy of Sciences current issue, 2015

Neurodegeneration correlates with Alzheimer’s disease (AD) symptoms, but the molecular identities of pathogenic amyloid β-protein (Aβ) oligomers and their targets, leading to neurodegeneration, remain unclear. Amylospheroids (ASPD) are AD patient-derived 10- to 15-nm spherical Aβ oligomers that ...

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Activity-dependent BDNF release via endocytic pathways is regulated by synaptotagmin-6 and complexin [Neuroscience]

11-Aug-2015 | Yu-Hui Wong; Chia-Ming Lee; Wenjun Xie; Bianxiao Cui; Mu-ming Poo, Proceedings of the National Academy of Sciences current issue, 2015

Brain-derived neurotrophic factor (BDNF) is known to modulate synapse development and plasticity, but the source of synaptic BDNF and molecular mechanisms regulating BDNF release remain unclear. Using exogenous BDNF tagged with quantum dots (BDNF-QDs), we found that endocytosed BDNF-QDs were ...

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Wiring cost and topological participation of the mouse brain connectome [Neuroscience]

11-Aug-2015 | Mikail Rubinov; Rolf J. F. Ypma; Charles Watson; Edward T. Bullmore, Proceedings of the National Academy of Sciences current issue, 2015

Brain connectomes are topologically complex systems, anatomically embedded in 3D space. Anatomical conservation of “wiring cost” explains many but not all aspects of these networks. Here, we examined the relationship between topology and wiring cost in the mouse connectome by using data from 461 ...

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Activity-dependent mismatch between axo-axonic synapses and the axon initial segment controls neuronal output [Neuroscience]

04-Aug-2015 | Winnie Wefelmeyer; Daniel Cattaert; Juan Burrone, Proceedings of the National Academy of Sciences current issue, 2015

The axon initial segment (AIS) is a structure at the start of the axon with a high density of sodium and potassium channels that defines the site of action potential generation. It has recently been shown that this structure is plastic and can change its position along the axon, as...

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