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1,347 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

Tracking brain arousal fluctuations with fMRI [Neuroscience]

19-Apr-2016 | Catie Chang; David A. Leopold; Marieke Louise Schölvinck; Hendrik Mandelkow; Dante Picchioni; Xiao Liu; Frank Q. Ye; ..., Proceedings of the National Academy of Sciences current issue, 2016

Changes in brain activity accompanying shifts in vigilance and arousal can interfere with the study of other intrinsic and task-evoked characteristics of brain function. However, the difficulty of tracking and modeling the arousal state during functional MRI (fMRI) typically precludes the ...

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Functional network inference of the suprachiasmatic nucleus [Neuroscience]

19-Apr-2016 | John H. Abel; Kirsten Meeker; Daniel Granados-Fuentes; Peter C. St. John; Thomas J. Wang; Benjamin B. Bales; Francis ..., Proceedings of the National Academy of Sciences current issue, 2016

In the mammalian suprachiasmatic nucleus (SCN), noisy cellular oscillators communicate within a neuronal network to generate precise system-wide circadian rhythms. Although the intracellular genetic oscillator and intercellular biochemical coupling mechanisms have been examined previously, the ...

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Inflammatory and neuropathic cold allodynia are selectively mediated by the neurotrophic factor receptor GFR{alpha}3 [Neuroscience]

19-Apr-2016 | Erika K. Lippoldt; Serra Ongun; Geoffrey K. Kusaka; David D. McKemy, Proceedings of the National Academy of Sciences current issue, 2016

Tissue injury prompts the release of a number of proalgesic molecules that induce acute and chronic pain by sensitizing pain-sensing neurons (nociceptors) to heat and mechanical stimuli. In contrast, many proalgesics have no effect on cold sensitivity or can inhibit cold-sensitive neurons and ...

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Paclitaxel-induced epithelial damage and ectopic MMP-13 expression promotes neurotoxicity in zebrafish [Neuroscience]

12-Apr-2016 | Thomas S. Lisse; Leah J. Middleton; Adriana D. Pellegrini; Paige B. Martin; Emily L. Spaulding; Olivia Lopes; Elizab ..., Proceedings of the National Academy of Sciences current issue, 2016

Paclitaxel is a microtubule-stabilizing chemotherapeutic agent that is widely used in cancer treatment and in a number of curative and palliative regimens. Despite its beneficial effects on cancer, paclitaxel also damages healthy tissues, most prominently the peripheral sensory nervous system. ...

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Discovering governing equations from data by sparse identification of nonlinear dynamical systems [Applied Mathematics]

12-Apr-2016 | Steven L. Brunton; Joshua L. Proctor; J. Nathan Kutz, Proceedings of the National Academy of Sciences current issue, 2016

Extracting governing equations from data is a central challenge in many diverse areas of science and engineering. Data are abundant whereas models often remain elusive, as in climate science, neuroscience, ecology, finance, and epidemiology, to name only a few examples. In this work, we combine ...

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Representation of spontaneous movement by dopaminergic neurons is cell-type selective and disrupted in parkinsonism [Neuroscience]

12-Apr-2016 | Paul D. Dodson; Jakob K. Dreyer; Katie A. Jennings; Emilie C. J. Syed; Richard Wade-Martins; Stephanie J. Cragg; J. ..., Proceedings of the National Academy of Sciences current issue, 2016

Midbrain dopaminergic neurons are essential for appropriate voluntary movement, as epitomized by the cardinal motor impairments arising in Parkinson’s disease. Understanding the basis of such motor control requires understanding how the firing of different types of dopaminergic neuron relates to ...

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Dopamine synapse is a neuroligin-2-mediated contact between dopaminergic presynaptic and GABAergic postsynaptic structures [Neuroscience]

12-Apr-2016 | Motokazu Uchigashima; Toshihisa Ohtsuka; Kazuto Kobayashi; Masahiko Watanabe, Proceedings of the National Academy of Sciences current issue, 2016

Midbrain dopamine neurons project densely to the striatum and form so-called dopamine synapses on medium spiny neurons (MSNs), principal neurons in the striatum. Because dopamine receptors are widely expressed away from dopamine synapses, it remains unclear how dopamine synapses are involved in ...

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Mixing and matching TREK/TRAAK subunits generate heterodimeric K2P channels with unique properties [Neuroscience]

12-Apr-2016 | Sandy Blin; Ismail Ben Soussia; Eun-Jin Kim; Frédéric Brau; Dawon Kang; Florian Lesage; Delphine Bichet, Proceedings of the National Academy of Sciences current issue, 2016

The tandem of pore domain in a weak inwardly rectifying K+ channel (Twik)-related acid-arachidonic activated K+ channel (TRAAK) and Twik-related K+ channels (TREK) 1 and TREK2 are active as homodimers gated by stretch, fatty acids, pH, and G protein-coupled receptors. These two-pore domain ...

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Spatiotemporal dynamics of auditory attention synchronize with speech [Neuroscience]

05-Apr-2016 | Malte Wöstmann; Björn Herrmann; Burkhard Maess; Jonas Obleser, Proceedings of the National Academy of Sciences current issue, 2016

Attention plays a fundamental role in selectively processing stimuli in our environment despite distraction. Spatial attention induces increasing and decreasing power of neural alpha oscillations (8–12 Hz) in brain regions ipsilateral and contralateral to the locus of attention, respectively. ...

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Behavioral contagion during learning about another agent’s risk-preferences acts on the neural representation of decision-risk [Neuroscience]

05-Apr-2016 | Shinsuke Suzuki; Emily L. S. Jensen; Peter Bossaerts; John P. O’Doherty, Proceedings of the National Academy of Sciences current issue, 2016

Our attitude toward risk plays a crucial role in influencing our everyday decision-making. Despite its importance, little is known about how human risk-preference can be modulated by observing risky behavior in other agents at either the behavioral or the neural level. Using fMRI combined with ...

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