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868 Newest Publications in proceedings of the national academy of sciences current issue

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GABAB autoreceptor-mediated cell type-specific reduction of inhibition in epileptic mice [Neuroscience]

10-09-2013 | Tamar Dugladze; Nino Maziashvili; Christoph Börgers; Shalva Gurgenidze; Ute Häussler; Aline Winkelmann; Carola A. Ha ..., Proceedings of the National Academy of Sciences current issue, 2013

GABAB receptors (GABABRs) mediate slow inhibitory effects on neuronal excitability and synaptic transmission in the brain. However, the GABABR agonist baclofen can also promote excitability and seizure generation in human patients and animals models. Here we show that baclofen has ...

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Natalisin, a tachykinin-like signaling system, regulates sexual activity and fecundity in insects [Neuroscience]

10-09-2013 | Hongbo Jiang; Ankhbayar Lkhagva; Ivana Daubnerová; Hyo-Seok Chae; Ladislav Šimo; Sung-Hwan Jung; Yeu-Kyung Yoon; Na- ..., Proceedings of the National Academy of Sciences current issue, 2013

An arthropod-specific peptidergic system, the neuropeptide designated here as natalisin and its receptor, was identified and investigated in three holometabolous insect species: Drosophila melanogaster, Tribolium castaneum, and Bombyx mori. In all three species, natalisin expression was observed ...

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Expanding the primate body schema in sensorimotor cortex by virtual touches of an avatar [Neuroscience]

10-09-2013 | Solaiman Shokur; Joseph E. O’Doherty; Jesse A. Winans; Hannes Bleuler; Mikhail A. Lebedev; Miguel A. L. Nicolelis, Proceedings of the National Academy of Sciences current issue, 2013

The brain representation of the body, called the body schema, is susceptible to plasticity. For instance, subjects experiencing a rubber hand illusion develop a sense of ownership of a mannequin hand when they view it being touched while tactile stimuli are simultaneously applied to their own ...

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Coherent delta-band oscillations between cortical areas correlate with decision making [Neuroscience]

10-09-2013 | Verónica Nácher; Anders Ledberg; Gustavo Deco; Ranulfo Romo, Proceedings of the National Academy of Sciences current issue, 2013

Coherent oscillations in the theta-to-gamma frequency range have been proposed as a mechanism that coordinates neural activity in large-scale cortical networks in sensory, motor, and cognitive tasks. Whether this mechanism also involves coherent oscillations at delta frequencies (1–4 Hz) is not ...

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Neurokinin3 receptor as a target to predict and improve learning and memory in the aged organism [Neuroscience]

10-09-2013 | Maria A. de Souza Silva; Bernd Lenz; Andrea Rotter; Teresa Biermann; Oliver Peters; Alfredo Ramirez; Frank Jessen; W ..., Proceedings of the National Academy of Sciences current issue, 2013

Impaired learning and memory performance is often found in aging as an early sign of dementia. It is associated with neuronal loss and reduced functioning of cholinergic networks. Here we present evidence that the neurokinin3 receptors (NK3-R) and their influence on acetylcholine (ACh) release ...

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Role of activity-dependent BDNF expression in hippocampal-prefrontal cortical regulation of behavioral perseverance [Neuroscience]

10-09-2013 | Kazuko Sakata; Keri Martinowich; Newton H. Woo; Robert J. Schloesser; Dennisse V. Jimenez; Yuanyuan Ji; Liya Shen; B ..., Proceedings of the National Academy of Sciences current issue, 2013

Activity-dependent gene transcription, including that of the brain-derived neurotrophic factor (Bdnf) gene, has been implicated in various cognitive functions. We previously demonstrated that mutant mice with selective disruption of activity-dependent BDNF expression (BDNF-KIV mice) exhibit ...

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Quantitative basis for neuroimaging of cortical laminae with calibrated functional MRI [Neuroscience]

10-09-2013 | Peter Herman; Basavaraju G. Sanganahalli; Hal Blumenfeld; Douglas L. Rothman; Fahmeed Hyder, Proceedings of the National Academy of Sciences current issue, 2013

Layer-specific neurophysiologic, hemodynamic, and metabolic measurements are needed to interpret high-resolution functional magnetic resonance imaging (fMRI) data in the cerebral cortex. We examined how neurovascular and neurometabolic couplings vary vertically in the rat’s somatosensory cortex. ...

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Superpriming of synaptic vesicles after their recruitment to the readily releasable pool [Neuroscience]

10-09-2013 | Jae Sung Lee; Won-Kyung Ho; Erwin Neher; Suk-Ho Lee, Proceedings of the National Academy of Sciences current issue, 2013

Recruitment of release-competent vesicles during sustained synaptic activity is one of the major factors governing short-term plasticity. During bursts of synaptic activity, vesicles are recruited to a fast-releasing pool from a reluctant vesicle pool through an actin-dependent mechanism. We now ...

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Cone photoreceptor types in zebrafish are generated by symmetric terminal divisions of dedicated precursors [Neuroscience]

10-09-2013 | Sachihiro C. Suzuki; Adam Bleckert; Philip R. Williams; Masaki Takechi; Shoji Kawamura; Rachel O. L. Wong, Proceedings of the National Academy of Sciences current issue, 2013

Proper functioning of sensory systems requires the generation of appropriate numbers and proportions of neuronal subtypes that encode distinct information. Perception of color relies on signals from multiple cone photoreceptor types. In cone-dominated retinas, each cone expresses a single opsin ...

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Presenilin-ryanodine receptor connection [Neuroscience]

10-09-2013 | Luciano D’Adamio; Pablo E. Castillo, Proceedings of the National Academy of Sciences current issue, 2013

The Presenilins (PS) gene family is composed of two members: PS1 and PS2. Mutations in PSs are linked to familial Alzheimer's disease (FAD) (1). PSs are the catalytic subunits of the γ-secretase multimolecular complex, which mediates the intramembranous cleavage of many type I membrane proteins, ...

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