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923 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

Autism as a disorder of prediction [Neuroscience]

21-10-2014 | Pawan Sinha; Margaret M. Kjelgaard; Tapan K. Gandhi; Kleovoulos Tsourides; Annie L. Cardinaux; Dimitrios Pantazis; S ..., Proceedings of the National Academy of Sciences current issue, 2014

A rich collection of empirical findings accumulated over the past three decades attests to the diversity of traits that constitute the autism phenotypes. It is unclear whether subsets of these traits share any underlying causality. This lack of a cohesive conceptualization of the disorder has ...

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Cross-modal effects of value on perceptual acuity and stimulus encoding [Neuroscience]

21-10-2014 | Arezoo Pooresmaeili; Thomas H. B. FitzGerald; Dominik R. Bach; Ulf Toelch; Florian Ostendorf; Raymond J. Dolan, Proceedings of the National Academy of Sciences current issue, 2014

Cross-modal interactions are very common in perception. An important feature of many perceptual stimuli is their reward-predicting properties, the utilization of which is essential for adaptive behavior. What is unknown is whether reward associations in one sensory modality influence perception ...

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Left-right dissociation of hippocampal memory processes in mice [Neuroscience]

21-10-2014 | Olivia A. Shipton; Mohamady El-Gaby; John Apergis-Schoute; Karl Deisseroth; David M. Bannerman; Ole Paulsen; Michael ..., Proceedings of the National Academy of Sciences current issue, 2014

Left–right asymmetries have likely evolved to make optimal use of bilaterian nervous systems; however, little is known about the synaptic and circuit mechanisms that support divergence of function between equivalent structures in each hemisphere. Here we examined whether lateralized hippocampal ...

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Netrin-4 regulates thalamocortical axon branching in an activity-dependent fashion [Neuroscience]

21-10-2014 | Yasufumi Hayano; Kensuke Sasaki; Nami Ohmura; Makoto Takemoto; Yurie Maeda; Toshihide Yamashita; Yoshio Hata; Kazuhi ..., Proceedings of the National Academy of Sciences current issue, 2014

Axon branching is remodeled by sensory-evoked and spontaneous neuronal activity. However, the underlying molecular mechanism is largely unknown. Here, we demonstrate that the netrin family member netrin-4 (NTN4) contributes to activity-dependent thalamocortical (TC) axon branching. In the ...

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Entrained neural oscillations in multiple frequency bands comodulate behavior [Neuroscience]

14-10-2014 | Molly J. Henry; Björn Herrmann; Jonas Obleser, Proceedings of the National Academy of Sciences current issue, 2014

Our sensory environment is teeming with complex rhythmic structure, to which neural oscillations can become synchronized. Neural synchronization to environmental rhythms (entrainment) is hypothesized to shape human perception, as rhythmic structure acts to temporally organize cortical ...

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Proteopathic tau seeding predicts tauopathy in vivo [Neuroscience]

14-10-2014 | Brandon B. Holmes; Jennifer L. Furman; Thomas E. Mahan; Tritia R. Yamasaki; Hilda Mirbaha; William C. Eades; Larisa ..., Proceedings of the National Academy of Sciences current issue, 2014

Transcellular propagation of protein aggregates, or proteopathic seeds, may drive the progression of neurodegenerative diseases in a prion-like manner. In tauopathies such as Alzheimer’s disease, this model predicts that tau seeds propagate pathology through the brain via cell–cell transfer in ...

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The hereditary spastic paraplegia-related enzyme DDHD2 is a principal brain triglyceride lipase [Neuroscience]

14-10-2014 | Jordon M. Inloes; Ku-Lung Hsu; Melissa M. Dix; Andreu Viader; Kim Masuda; Thais Takei; Malcolm R. Wood; Benjamin F. ..., Proceedings of the National Academy of Sciences current issue, 2014

Complex hereditary spastic paraplegia (HSP) is a genetic disorder that causes lower limb spasticity and weakness and intellectual disability. Deleterious mutations in the poorly characterized serine hydrolase DDHD2 are a causative basis for recessive complex HSP. DDHD2 exhibits phospholipase ...

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Stephen F. Heinemann: A true original [Retrospectives]

07-10-2014 | Greg Lemke; David Julius, Proceedings of the National Academy of Sciences current issue, 2014

Steve Heinemann, one of the founders of 21st century neuroscience, died on August 6, 2014. To those who had the honor to know him, “Stevie” was a man of personal and professional generosity, contagious energy, scientific integrity, and genuine enthusiasm. His death is a profound loss for all. ...

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Distinct frequencies mark the direction of cortical communication [Neuroscience]

07-10-2014 | Nathaniel J. Killian; Elizabeth A. Buffalo, Proceedings of the National Academy of Sciences current issue, 2014

The capacity of the nervous system to perceive sensory information, form new memories, navigate through space, and make decisions relies on complex communication within and between brain areas. Anatomical studies have identified the routes by which information flows within the six layers of the ...

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Object and spatial mnemonic interference differentially engage lateral and medial entorhinal cortex in humans [Neuroscience]

07-10-2014 | Zachariah M. Reagh; Michael A. Yassa, Proceedings of the National Academy of Sciences current issue, 2014

Recent models of episodic memory propose a division of labor among medial temporal lobe cortices comprising the parahippocampal gyrus. Specifically, perirhinal and lateral entorhinal cortices are thought to comprise an object/item information pathway, whereas parahippocampal and medial entorhinal ...

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