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1,291 Newest Publications in proceedings of the national academy of sciences current issue

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Stimulus-induced visual cortical networks are recapitulated by spontaneous local and interareal synchronization [Neuroscience]

02-Feb-2016 | Christopher M. Lewis; Conrado A. Bosman; Thilo Womelsdorf; Pascal Fries, Proceedings of the National Academy of Sciences current issue, 2016

Intrinsic covariation of brain activity has been studied across many levels of brain organization. Between visual areas, neuronal activity covaries primarily among portions with similar retinotopic selectivity. We hypothesized that spontaneous interareal coactivation is subserved by neuronal ...

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Central auditory neurons have composite receptive fields [Neuroscience]

02-Feb-2016 | Andrei S. Kozlov; Timothy Q. Gentner, Proceedings of the National Academy of Sciences current issue, 2016

High-level neurons processing complex, behaviorally relevant signals are sensitive to conjunctions of features. Characterizing the receptive fields of such neurons is difficult with standard statistical tools, however, and the principles governing their organization remain poorly understood. ...

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Brain responses in humans reveal ideal observer-like sensitivity to complex acoustic patterns [Neuroscience]

02-Feb-2016 | Nicolas Barascud; Marcus T. Pearce; Timothy D. Griffiths; Karl J. Friston; Maria Chait, Proceedings of the National Academy of Sciences current issue, 2016

We use behavioral methods, magnetoencephalography, and functional MRI to investigate how human listeners discover temporal patterns and statistical regularities in complex sound sequences. Sensitivity to patterns is fundamental to sensory processing, in particular in the auditory system, because ...

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Gene therapy blockade of dorsal striatal p11 improves motor function and dyskinesia in parkinsonian mice [Neuroscience]

02-Feb-2016 | Roberta Marongiu; Margarita Arango-Lievano; Veronica Francardo; Peter Morgenstern; Xiaoqun Zhang; M. Angela Cenci; P ..., Proceedings of the National Academy of Sciences current issue, 2016

Complications of dopamine replacement for Parkinson’s disease (PD) can limit therapeutic options, leading to interest in identifying novel pathways that can be exploited to improve treatment. p11 (S100A10) is a cellular scaffold protein that binds to and potentiates the activity of various ion ...

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p11 modulates L-DOPA therapeutic effects and dyskinesia via distinct cell types in experimental Parkinsonism [Neuroscience]

02-Feb-2016 | Nicoletta Schintu; Xiaoqun Zhang; Alexandra Alvarsson; Roberta Marongiu; Michael G. Kaplitt; Paul Greengard; Per Sve ..., Proceedings of the National Academy of Sciences current issue, 2016

The reduced movement repertoire of Parkinson’s disease (PD) is mainly due to degeneration of nigrostriatal dopamine neurons. Restoration of dopamine transmission by levodopa (L-DOPA) relieves motor symptoms of PD but often causes disabling dyskinesias. Subchronic L-DOPA increases levels of ...

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Beneficial effects of IL-37 after spinal cord injury in mice [Neuroscience]

02-Feb-2016 | Marina Coll-Miró; Isaac Francos-Quijorna; Eva Santos-Nogueira; Abel Torres-Espin; Philip Bufler; Charles A. Dinarell ..., Proceedings of the National Academy of Sciences current issue, 2016

IL-37, a member of the IL-1 family, broadly reduces innate inflammation as well as acquired immunity. Whether the antiinflammatory properties of IL-37 extend to the central nervous system remains unknown, however. In the present study, we subjected mice transgenic for human IL-37 (hIL-37tg) and ...

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Correction for Ogasawara et al., Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition [Correction]

02-Feb-2016 | Proceedings of the National Academy of Sciences current issue, 2016

NEUROSCIENCE Correction for “Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition,” by Daisuke Ogasawara, Hui Deng, Andreu Viader, Marc P. Baggelaar, Arjen Breman, Hans den Dulk, Adriann M. C. H. van den Nieuwendijk, Marjolein Soethoudt, Tom van ...

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A transcriptional signature of hub connectivity in the mouse connectome [Neuroscience]

02-Feb-2016 | Ben D. Fulcher; Alex Fornito, Proceedings of the National Academy of Sciences current issue, 2016

Connectivity is not distributed evenly throughout the brain. Instead, it is concentrated on a small number of highly connected neural elements that act as network hubs. Across different species and measurement scales, these hubs show dense interconnectivity, forming a core or “rich club” that ...

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The point of no return in vetoing self-initiated movements [Neuroscience]

26-Jan-2016 | Matthias Schultze-Kraft; Daniel Birman; Marco Rusconi; Carsten Allefeld; Kai Görgen; Sven Dähne; Benjamin Blankertz; ..., Proceedings of the National Academy of Sciences current issue, 2016

In humans, spontaneous movements are often preceded by early brain signals. One such signal is the readiness potential (RP) that gradually arises within the last second preceding a movement. An important question is whether people are able to cancel movements after the elicitation of such RPs, ...

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Altered short-term synaptic plasticity and reduced muscle strength in mice with impaired regulation of presynaptic CaV2.1 Ca2+ channels [Neuroscience]

26-Jan-2016 | Evanthia Nanou; Jin Yan; Nicholas P. Whitehead; Min Jeong Kim; Stanley C. Froehner; Todd Scheuer; William A. Catterall, Proceedings of the National Academy of Sciences current issue, 2016

Facilitation and inactivation of P/Q-type calcium (Ca2+) currents through the regulation of voltage-gated Ca2+ (CaV) 2.1 channels by Ca2+ sensor (CaS) proteins contributes to the facilitation and rapid depression of synaptic transmission in cultured neurons that transiently express CaV2.1 ...

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