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1,129 Newest Publications in proceedings of the national academy of sciences current issue
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matching the following criteria
Central role of liver in anticancer and radioprotective activities of Toll-like receptor 5 agonist [Medical Sciences]
14-05-2013 | Lyudmila G. Burdelya; Craig M. Brackett; Bojidar Kojouharov; Ilya I. Gitlin; Katerina I. Leonova; Anatoli S. Gleiber ..., Proceedings of the National Academy of Sciences current issue, 2013
Vertebrate Toll-like receptor 5 (TLR5) recognizes bacterial flagellin proteins and activates innate immune responses to motile bacteria. In addition, activation of TLR5 signaling can inhibit growth of TLR5-expressing tumors and protect normal tissues from radiation and ischemia-reperfusion ...
Latency of Epstein-Barr virus is disrupted by gain-of-function mutant cellular AP-1 proteins that preferentially bind methylated DNA [Medical Sciences]
14-05-2013 | Kuan-Ping Yu; Lee Heston; Richard Park; Zhaowei Ding; Ruth Wang’ondu; Henri-Jacques Delecluse; George Miller, Proceedings of the National Academy of Sciences current issue, 2013
ZEBReplication Activator (ZEBRA), a viral basic zipper protein that initiates the Epstein–Barr viral lytic cycle, binds to DNA and activates transcription through heptamer ZEBRA response elements (ZREs) related to AP-1 sites. A component of the biologic action of ZEBRA is attributable to ...
Rhomboid domain-containing protein 3 is a negative regulator of TLR3-triggered natural killer cell activation [Immunology]
07-05-2013 | Juan Liu; Shuxun Liu; Meng Xia; Sheng Xu; Chunmei Wang; Yan Bao; Minghong Jiang; Yue Wu; Tian Xu; Xuetao Cao, Proceedings of the National Academy of Sciences current issue, 2013
Rhomboid domain-containing protein 3 (Rhbdd3), which belongs to a family of proteins with rhomboid domain, is widely expressed in immune cells; however, the roles of the Rhbdd members, including Rhbdd3, in immunity remain unknown. Natural killer (NK) cells are critical for host immune defense ...
Controlling electron transfer at the microbe-mineral interface [Microbiology]
07-05-2013 | David J. Richardson; Julea N. Butt; Thomas A. Clarke, Proceedings of the National Academy of Sciences current issue, 2013
Remarkably, many bacteria live and thrive in the earth’s subsurface by respiring extracellular insoluble minerals. Okamato et al. (1) in PNAS report how this process may be accelerated by the presence of flavins that bind as cofactors to electron transport proteins on the cell surface that ...
The molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteins [Immunology]
07-05-2013 | Jacinto López-Sagaseta; Charles L. Dulberger; James E. Crooks; Chelsea D. Parks; Adrienne M. Luoma; Amanda McFedries ..., Proceedings of the National Academy of Sciences current issue, 2013
Mucosal-associated invariant T (MAIT) cells are an evolutionarily conserved αβ T-cell lineage that express a semi-invariant T-cell receptor (TCR) restricted to the MHC related-1 (MR1) protein. MAIT cells are dependent upon MR1 expression and exposure to microbes for their development and ...
HPV-18 E6 mutants reveal p53 modulation of viral DNA amplification in organotypic cultures [Microbiology]
07-05-2013 | Eun-Young Kho; Hsu-Kun Wang; N. Sanjib Banerjee; Thomas R. Broker; Louise T. Chow, Proceedings of the National Academy of Sciences current issue, 2013
Human papillomaviruses (HPVs) amplify in differentiated strata of a squamous epithelium. The HPV E7 protein destabilizes the p130/retinoblastoma susceptibility protein family of tumor suppressors and reactivates S-phase reentry, thereby facilitating viral DNA amplification. The high-risk HPV ...
Precise timing of ATPase activation drives targeting of tail-anchored proteins [Biochemistry]
07-05-2013 | Michael E. Rome; Meera Rao; William M. Clemons; Shu-ou Shan, Proceedings of the National Academy of Sciences current issue, 2013
The localization of tail-anchored (TA) proteins, whose transmembrane domain resides at the extreme C terminus, presents major challenges to cellular protein targeting machineries. In eukaryotic cells, the highly conserved ATPase, guided entry of tail-anchored protein 3 (Get3), coordinates the ...
Identification and characterization of a previously undescribed family of sequence-specific DNA-binding domains [Biochemistry]
07-05-2013 | Matthew B. Lohse; Aaron D. Hernday; Polly M. Fordyce; Liron Noiman; Trevor R. Sorrells; Victor Hanson-Smith; Clariss ..., Proceedings of the National Academy of Sciences current issue, 2013
Sequence-specific DNA-binding proteins are among the most important classes of gene regulatory proteins, controlling changes in transcription that underlie many aspects of biology. In this work, we identify a transcriptional regulator from the human fungal pathogen Candida albicans that binds ...
Different 3D domain-swapped oligomeric cyanovirin-N structures suggest trapped folding intermediates [Biophysics and Computational Biology]
07-05-2013 | Leonardus M. I. Koharudin; Lin Liu; Angela M. Gronenborn, Proceedings of the National Academy of Sciences current issue, 2013
Although it has long been established that the amino acid sequence encodes the fold of a protein, how individual proteins arrive at their final conformation is still difficult to predict, especially for oligomeric structures. Here, we present a comprehensive characterization of oligomeric ...
Transporter-mediated biofuel secretion [Applied Biological Sciences]
07-05-2013 | Rupak Doshi; Tuan Nguyen; Geoffrey Chang, Proceedings of the National Academy of Sciences current issue, 2013
Engineering microorganisms to produce biofuels is currently among the most promising strategies in renewable energy. However, harvesting these organisms for extracting biofuels is energy- and cost-intensive, limiting the commercial feasibility of large-scale production. Here, we demonstrate ...
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