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1,451 Newest Publications in proceedings of the national academy of sciences current issue

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Retro-translocation of mitochondrial intermembrane space proteins [Biochemistry]

23-Jun-2015 | Piotr Bragoszewski; Michal Wasilewski; Paulina Sakowska; Agnieszka Gornicka; Lena Böttinger; Jian Qiu; Nils Wiedeman ..., Proceedings of the National Academy of Sciences current issue, 2015

The content of mitochondrial proteome is maintained through two highly dynamic processes, the influx of newly synthesized proteins from the cytosol and the protein degradation. Mitochondrial proteins are targeted to the intermembrane space by the mitochondrial intermembrane space assembly pathway ...

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Phosphoregulatory protein 14-3-3 facilitates SAC1 transport from the endoplasmic reticulum [Biochemistry]

23-Jun-2015 | Kanika Bajaj Pahuja; Jinzhi Wang; Anastasia Blagoveshchenskaya; Lillian Lim; M. S. Madhusudhan; Peter Mayinger; Rand ..., Proceedings of the National Academy of Sciences current issue, 2015

Most secretory cargo proteins in eukaryotes are synthesized in the endoplasmic reticulum and actively exported in membrane-bound vesicles that are formed by the cytosolic coat protein complex II (COPII). COPII proteins are assisted by a variety of cargo-specific adaptor proteins required for the ...

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Conformational processing of oncogenic v-Src kinase by the molecular chaperone Hsp90 [Biochemistry]

23-Jun-2015 | Edgar E. Boczek; Lasse G. Reefschläger; Marco Dehling; Tobias J. Struller; Elisabeth Häusler; Andreas Seidl; Ville R ..., Proceedings of the National Academy of Sciences current issue, 2015

Hsp90 is a molecular chaperone involved in the activation of numerous client proteins, including many kinases. The most stringent kinase client is the oncogenic kinase v-Src. To elucidate how Hsp90 chaperones kinases, we reconstituted v-Src kinase chaperoning in vitro and show that its activation ...

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Tau stabilizes microtubules by binding at the interface between tubulin heterodimers [Biophysics and Computational Biology]

16-Jun-2015 | Harindranath Kadavath; Romina V. Hofele; Jacek Biernat; Satish Kumar; Katharina Tepper; Henning Urlaub; Eckhard Mand ..., Proceedings of the National Academy of Sciences current issue, 2015

The structure, dynamic behavior, and spatial organization of microtubules are regulated by microtubule-associated proteins. An important microtubule-associated protein is the protein Tau, because its microtubule interaction is impaired in the course of Alzheimer’s disease and several other ...

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Temperature dependence of amino acid hydrophobicities [Chemistry]

16-Jun-2015 | Richard Wolfenden; Charles A. Lewis Jr.; Yang Yuan; Charles W. Carter Jr., Proceedings of the National Academy of Sciences current issue, 2015

The hydrophobicities of the 20 common amino acids are reflected in their tendencies to appear in interior positions in globular proteins and in deeply buried positions of membrane proteins. To determine whether these relationships might also have been valid in the warm surroundings where life may ...

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Accurate secondary structure prediction and fold recognition for circular dichroism spectroscopy [Biophysics and Computational Biology]

16-Jun-2015 | András Micsonai; Frank Wien; Linda Kernya; Young-Ho Lee; Yuji Goto; Matthieu Réfrégiers; József Kardos, Proceedings of the National Academy of Sciences current issue, 2015

Circular dichroism (CD) spectroscopy is a widely used technique for the study of protein structure. Numerous algorithms have been developed for the estimation of the secondary structure composition from the CD spectra. These methods often fail to provide acceptable results on α/β-mixed or ...

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Water-soluble chlorophyll protein is involved in herbivore resistance activation during greening of Arabidopsis thaliana [Plant Biology]

09-Jun-2015 | Edouard Boex-Fontvieille; Sachin Rustgi; Diter von Wettstein; Steffen Reinbothe; Christiane Reinbothe, Proceedings of the National Academy of Sciences current issue, 2015

Water-soluble chlorophyll proteins (WSCPs) constitute a small family of unusual chlorophyll (Chl)-binding proteins that possess a Kunitz-type protease inhibitor domain. In Arabidopsis thaliana, a WSCP has been identified, named AtWSCP, that forms complexes with Chl and the Chl precursor ...

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BCL-2 family member BOK promotes apoptosis in response to endoplasmic reticulum stress [Cell Biology]

09-Jun-2015 | Marcos A. Carpio; Michael Michaud; Wenping Zhou; Jill K. Fisher; Loren D. Walensky; Samuel G. Katz, Proceedings of the National Academy of Sciences current issue, 2015

B-cell lymphoma 2 (BCL-2) ovarian killer (BOK) is a BCL-2 family protein with high homology to the multidomain proapoptotic proteins BAX and BAK, yet Bok−/− and even Bax−/−Bok−/− and Bak−/−Bok−/− mice were reported to have no overt phenotype or apoptotic defects in response to a host of classical ...

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BDNF pro-peptide actions facilitate hippocampal LTD and are altered by the common BDNF polymorphism Val66Met [Neuroscience]

09-Jun-2015 | Toshiyuki Mizui; Yasuyuki Ishikawa; Haruko Kumanogoh; Maria Lume; Tomoya Matsumoto; Tomoko Hara; Shigeto Yamawaki; M ..., Proceedings of the National Academy of Sciences current issue, 2015

Most growth factors are initially synthesized as precursor proteins and subsequently processed into their mature form by proteolytic cleavage, resulting in simultaneous removal of a pro-peptide. However, compared with that of mature form, the biological role of the pro-peptide is poorly ...

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Reconstructing folding energy landscapes from splitting probability analysis of single-molecule trajectories [Biophysics and Computational Biology]

09-Jun-2015 | Ajay P. Manuel; John Lambert; Michael T. Woodside, Proceedings of the National Academy of Sciences current issue, 2015

Structural self-assembly in biopolymers, such as proteins and nucleic acids, involves a diffusive search for the minimum-energy state in a conformational free-energy landscape. The likelihood of folding proceeding to completion, as a function of the reaction coordinate used to monitor the ...

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