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1,572 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

Structural basis of collagen recognition by human osteoclast-associated receptor and design of osteoclastogenesis inhibitors [Immunology and Inflammation]

26-Jan-2016 | Joel Haywood; Jianxun Qi; Chun-Chi Chen; Guangwen Lu; Yingxia Liu; Jinghua Yan; Yi Shi; George F. Gao, Proceedings of the National Academy of Sciences current issue, 2016

Human osteoclast-associated receptor (OSCAR) is an immunoglobulin (Ig)-like collagen receptor that is up-regulated on osteoclasts during osteoclastogenesis and is expressed in a range of myeloid cells. As a member of the leukocyte receptor complex family of proteins, OSCAR shares a high degree of ...

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Altered short-term synaptic plasticity and reduced muscle strength in mice with impaired regulation of presynaptic CaV2.1 Ca2+ channels [Neuroscience]

26-Jan-2016 | Evanthia Nanou; Jin Yan; Nicholas P. Whitehead; Min Jeong Kim; Stanley C. Froehner; Todd Scheuer; William A. Catterall, Proceedings of the National Academy of Sciences current issue, 2016

Facilitation and inactivation of P/Q-type calcium (Ca2+) currents through the regulation of voltage-gated Ca2+ (CaV) 2.1 channels by Ca2+ sensor (CaS) proteins contributes to the facilitation and rapid depression of synaptic transmission in cultured neurons that transiently express CaV2.1 ...

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Calcium sensor regulation of the CaV2.1 Ca2+ channel contributes to short-term synaptic plasticity in hippocampal neurons [Neuroscience]

26-Jan-2016 | Evanthia Nanou; Jane M. Sullivan; Todd Scheuer; William A. Catterall, Proceedings of the National Academy of Sciences current issue, 2016

Short-term synaptic plasticity is induced by calcium (Ca2+) accumulating in presynaptic nerve terminals during repetitive action potentials. Regulation of voltage-gated CaV2.1 Ca2+ channels by Ca2+ sensor proteins induces facilitation of Ca2+ currents and synaptic facilitation in cultured neurons ...

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Critical roles of Gi/o proteins and phospholipase C-{delta}1 in the activation of receptor-operated TRPC4 channels [Pharmacology]

26-Jan-2016 | Dhananjay P. Thakur; Jin-bin Tian; Jaepyo Jeon; Jian Xiong; Yu Huang; Veit Flockerzi; Michael X. Zhu, Proceedings of the National Academy of Sciences current issue, 2016

Transient Receptor Potential Canonical (TRPC) proteins form nonselective cation channels commonly known to be activated downstream from receptors that signal through phospholipase C (PLC). Although TRPC3/C6/C7 can be directly activated by diacylglycerols produced by PLC breakdown of ...

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Small fluorescence-activating and absorption-shifting tag for tunable protein imaging in vivo [Cell Biology]

19-Jan-2016 | Marie-Aude Plamont; Emmanuelle Billon-Denis; Sylvie Maurin; Carole Gauron; Frederico M. Pimenta; Christian G. Specht ..., Proceedings of the National Academy of Sciences current issue, 2016

This paper presents Yellow Fluorescence-Activating and absorption-Shifting Tag (Y-FAST), a small monomeric protein tag, half as large as the green fluorescent protein, enabling fluorescent labeling of proteins in a reversible and specific manner through the reversible binding and activation of a ...

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Geometry-induced protein pattern formation [Physics]

19-Jan-2016 | Dominik Thalmeier; Jacob Halatek; Erwin Frey, Proceedings of the National Academy of Sciences current issue, 2016

Protein patterns are known to adapt to cell shape and serve as spatial templates that choreograph downstream processes like cell polarity or cell division. However, how can pattern-forming proteins sense and respond to the geometry of a cell, and what mechanistic principles underlie pattern ...

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Calcium-dependent oligomerization of CAR proteins at cell membrane modulates ABA signaling [Plant Biology]

19-Jan-2016 | Maira Diaz; Maria Jose Sanchez-Barrena; Juana Maria Gonzalez-Rubio; Lesia Rodriguez; Daniel Fernandez; Regina Antoni ..., Proceedings of the National Academy of Sciences current issue, 2016

Regulation of ion transport in plants is essential for cell function. Abiotic stress unbalances cell ion homeostasis, and plants tend to readjust it, regulating membrane transporters and channels. The plant hormone abscisic acid (ABA) and the second messenger Ca2+ are central in such processes, ...

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Human autoreactive T cells recognize CD1b and phospholipids [Immunology and Inflammation]

12-Jan-2016 | Ildiko Van Rhijn; Twan van Berlo; Tamara Hilmenyuk; Tan-Yun Cheng; Benjamin J. Wolf; Raju V. V. Tatituri; Adam P. Ul ..., Proceedings of the National Academy of Sciences current issue, 2016

In contrast with the common detection of T cells that recognize MHC, CD1a, CD1c, or CD1d proteins, CD1b autoreactive T cells have been difficult to isolate in humans. Here we report the development of polyvalent complexes of CD1b proteins and carbohydrate backbones (dextramers) and their use in ...

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Actin-dependent vacuolar occupancy of the cell determines auxin-induced growth repression [Plant Biology]

12-Jan-2016 | David Scheuring; Christian Löfke; Falco Krüger; Maike Kittelmann; Ahmed Eisa; Louise Hughes; Richard S. Smith; Chris ..., Proceedings of the National Academy of Sciences current issue, 2016

The cytoskeleton is an early attribute of cellular life, and its main components are composed of conserved proteins. The actin cytoskeleton has a direct impact on the control of cell size in animal cells, but its mechanistic contribution to cellular growth in plants remains largely elusive. Here, ...

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A single protein redox ruler [Chemistry]

12-Jan-2016 | Rajneesh K. Bains; Jeffrey J. Warren, Proceedings of the National Academy of Sciences current issue, 2016

Redox reactions are the heart of function in biological systems. Using a deceptively simple toolbox, consisting largely of first row transition metals and the 20 canonical amino acids, nature has evolved proteins that contain cofactors with reduction potentials (E°′) between +1 V and −1 V. ...

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