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460 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

Stress-induced gene expression and behavior are controlled by DNA methylation and methyl donor availability in the dentate gyrus [Neuroscience]

26-Apr-2016 | Emily A. Saunderson; Helen Spiers; Karen R. Mifsud; Maria Gutierrez-Mecinas; Alexandra F. Trollope; Abeera Shaikh; J ..., Proceedings of the National Academy of Sciences current issue, 2016

Stressful events evoke long-term changes in behavioral responses; however, the underlying mechanisms in the brain are not well understood. Previous work has shown that epigenetic changes and immediate-early gene (IEG) induction in stress-activated dentate gyrus (DG) granule neurons play a crucial ...

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Revealing catastrophic failure of leaf networks under stress [Environmental Sciences]

26-Apr-2016 | Timothy J. Brodribb; Diane Bienaimé; Philippe Marmottant, Proceedings of the National Academy of Sciences current issue, 2016

The intricate patterns of veins that adorn the leaves of land plants are among the most important networks in biology. Water flows in these leaf irrigation networks under tension and is vulnerable to embolism-forming cavitations, which cut off water supply, ultimately causing leaf death. ...

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Ancestral genetic diversity associated with the rapid spread of stress-tolerant coral symbionts in response to Holocene climate change [Evolution]

19-Apr-2016 | Benjamin C. C. Hume; Christian R. Voolstra; Chatchanit Arif; Cecilia D’Angelo; John A. Burt; Gal Eyal; Yossi Loya; J ..., Proceedings of the National Academy of Sciences current issue, 2016

Coral communities in the Persian/Arabian Gulf (PAG) withstand unusually high salinity levels and regular summer temperature maxima of up to ∼35 °C that kill conspecifics elsewhere. Due to the recent formation of the PAG and its subsequent shift to a hot climate, these corals have had ...

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Asymmetric arginine dimethylation of RelA provides a repressive mark to modulate TNF{alpha}/NF-{kappa}B response [Biochemistry]

19-Apr-2016 | Anja Reintjes; Julian E. Fuchs; Leopold Kremser; Herbert H. Lindner; Klaus R. Liedl; Lukas A. Huber; Taras Valovka, Proceedings of the National Academy of Sciences current issue, 2016

Nuclear factor kappa B (NF-κB) is an inducible transcription factor that plays critical roles in immune and stress responses and is often implicated in pathologies, including chronic inflammation and cancer. Although much has been learned about NF-κB–activating pathways, the specific repression ...

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Response of single bacterial cells to stress gives rise to complex history dependence at the population level [Population Biology]

12-Apr-2016 | Roland Mathis; Martin Ackermann, Proceedings of the National Academy of Sciences current issue, 2016

Most bacteria live in ever-changing environments where periods of stress are common. One fundamental question is whether individual bacterial cells have an increased tolerance to stress if they recently have been exposed to lower levels of the same stressor. To address this question, we worked ...

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Stress management strategies in single bacterial cells [Population Biology]

12-Apr-2016 | Siv G. E. Andersson, Proceedings of the National Academy of Sciences current issue, 2016

Microbial genomes are highly adaptable to changing environmental conditions (1). Mechanisms such as duplications, deletions, and horizontal gene transfer events generate diversity in bacterial gene repertoires. In effect, most free-living bacterial populations contain myriads of individual cells ...

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Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress [Pharmacology]

29-Mar-2016 | Qian Ren; Min Ma; Tamaki Ishima; Christophe Morisseau; Jun Yang; Karen M. Wagner; Ji-chun Zhang; Chun Yang; Wei Yao; ..., Proceedings of the National Academy of Sciences current issue, 2016

Depression is a severe and chronic psychiatric disease, affecting 350 million subjects worldwide. Although multiple antidepressants have been used in the treatment of depressive symptoms, their beneficial effects are limited. The soluble epoxide hydrolase (sEH) plays a key role in the ...

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Recognition of the disordered p53 transactivation domain by the transcriptional adapter zinc finger domains of CREB-binding protein [Biophysics and Computational Biology]

29-Mar-2016 | Alexander S. Krois; Josephine C. Ferreon; Maria A. Martinez-Yamout; H. Jane Dyson; Peter E. Wright, Proceedings of the National Academy of Sciences current issue, 2016

An important component of the activity of p53 as a tumor suppressor is its interaction with the transcriptional coactivators cyclic-AMP response element-binding protein (CREB)-binding protein (CBP) and p300, which activate transcription of p53-regulated stress response genes and stabilize p53 ...

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LSD1 modulates stress-evoked transcription of immediate early genes and emotional behavior [Neuroscience]

29-Mar-2016 | Francesco Rusconi; Barbara Grillo; Luisa Ponzoni; Silvia Bassani; Emanuela Toffolo; Leda Paganini; Alessandra Mallei ..., Proceedings of the National Academy of Sciences current issue, 2016

Behavioral changes in response to stressful stimuli can be controlled via adaptive epigenetic changes in neuronal gene expression. Here we indicate a role for the transcriptional corepressor Lysine-Specific Demethylase 1 (LSD1) and its dominant-negative splicing isoform neuroLSD1, in the ...

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ppGpp negatively impacts ribosome assembly affecting growth and antimicrobial tolerance in Gram-positive bacteria [Microbiology]

22-Mar-2016 | Rebecca M. Corrigan; Lauren E. Bellows; Alison Wood; Angelika Gründling, Proceedings of the National Academy of Sciences current issue, 2016

The stringent response is a survival mechanism used by bacteria to deal with stress. It is coordinated by the nucleotides guanosine tetraphosphate and pentaphosphate [(p)ppGpp], which interact with target proteins to promote bacterial survival. Although this response has been well characterized ...

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