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398 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart [Physiology]

21-Jul-2015 | Tyler P. Rasmussen; Yuejin Wu; Mei-ling A. Joiner; Olha M. Koval; Nicholas R. Wilson; Elizabeth D. Luczak; Qinchuan ..., Proceedings of the National Academy of Sciences current issue, 2015

Myocardial mitochondrial Ca2+ entry enables physiological stress responses but in excess promotes injury and death. However, tissue-specific in vivo systems for testing the role of mitochondrial Ca2+ are lacking. We developed a mouse model with myocardial delimited transgenic expression of a ...

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Endoplasmic reticulum stress in the peripheral nervous system is a significant driver of neuropathic pain [Medical Sciences]

21-Jul-2015 | Bora Inceoglu; Ahmed Bettaieb; Carlos A. Trindade da Silva; Kin Sing Stephen Lee; Fawaz G. Haj; Bruce D. Hammock, Proceedings of the National Academy of Sciences current issue, 2015

Despite intensive effort and resulting gains in understanding the mechanisms underlying neuropathic pain, limited success in therapeutic approaches have been attained. A recently identified, nonchannel, nonneurotransmitter therapeutic target for pain is the enzyme soluble epoxide hydrolase (sEH). ...

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Noradrenergic blockade stabilizes prefrontal activity and enables fear extinction under stress [Neuroscience]

14-Jul-2015 | Paul J. Fitzgerald; Thomas F. Giustino; Jocelyn R. Seemann; Stephen Maren, Proceedings of the National Academy of Sciences current issue, 2015

Stress-induced impairments in extinction learning are believed to sustain posttraumatic stress disorder (PTSD). Noradrenergic signaling may contribute to extinction impairments by modulating medial prefrontal cortex (mPFC) circuits involved in fear regulation. Here we demonstrate that aversive ...

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Osmotic stress induces phosphorylation of histone H3 at threonine 3 in pericentromeric regions of Arabidopsis thaliana [Plant Biology]

07-Jul-2015 | Zhen Wang; Juan Armando Casas-Mollano; Jianping Xu; Jean-Jack M. Riethoven; Chi Zhang; Heriberto Cerutti, Proceedings of the National Academy of Sciences current issue, 2015

Histone phosphorylation plays key roles in stress-induced transcriptional reprogramming in metazoans but its function(s) in land plants has remained relatively unexplored. Here we report that an Arabidopsis mutant defective in At3g03940 and At5g18190, encoding closely related Ser/Thr protein ...

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Political influences on greenhouse gas emissions from US states [Sustainability Science]

07-Jul-2015 | Thomas Dietz; Kenneth A. Frank; Cameron T. Whitley; Jennifer Kelly; Rachel Kelly, Proceedings of the National Academy of Sciences current issue, 2015

Starting at least in the 1970s, empirical work suggested that demographic (population) and economic (affluence) forces are the key drivers of anthropogenic stress on the environment. We evaluate the extent to which politics attenuates the effects of economic and demographic factors on ...

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An eIF2{alpha}-binding motif in protein phosphatase 1 subunit GADD34 and its viral orthologs is required to promote dephosphorylation of eIF2{alpha} [Biochemistry]

07-Jul-2015 | Margarito Rojas; Gabriel Vasconcelos; Thomas E. Dever, Proceedings of the National Academy of Sciences current issue, 2015

Transient protein synthesis inhibition, mediated by phosphorylation of the α subunit of eukaryotic translation initiation factor 2 (eIF2α), is an important protective mechanism cells use during stress conditions. Following relief of the stress, the growth arrest and DNA damage-inducible protein ...

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Climate mediates hypoxic stress on fish diversity and nursery function at the land-sea interface [Ecology]

30-Jun-2015 | Brent B. Hughes; Matthew D. Levey; Monique C. Fountain; Aaron B. Carlisle; Francisco P. Chavez; Mary G. Gleason, Proceedings of the National Academy of Sciences current issue, 2015

Coastal ecosystems provide numerous important ecological services, including maintenance of biodiversity and nursery grounds for many fish species of ecological and economic importance. However, human population growth has led to increased pollution, ocean warming, hypoxia, and habitat alteration ...

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Caffeine acts through neuronal adenosine A2A receptors to prevent mood and memory dysfunction triggered by chronic stress [Neuroscience]

23-Jun-2015 | Manuella P. Kaster; Nuno J. Machado; Henrique B. Silva; Ana Nunes; Ana Paula Ardais; Magda Santana; Younis Baqi; Chr ..., Proceedings of the National Academy of Sciences current issue, 2015

The consumption of caffeine (an adenosine receptor antagonist) correlates inversely with depression and memory deterioration, and adenosine A2A receptor (A2AR) antagonists emerge as candidate therapeutic targets because they control aberrant synaptic plasticity and afford neuroprotection. ...

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Selective buckling via states of self-stress in topological metamaterials [Applied Physical Sciences]

23-Jun-2015 | Jayson Paulose; Anne S. Meeussen; Vincenzo Vitelli, Proceedings of the National Academy of Sciences current issue, 2015

States of self-stress—tensions and compressions of structural elements that result in zero net forces—play an important role in determining the load-bearing ability of structures ranging from bridges to metamaterials with tunable mechanical properties. We exploit a class of recently introduced ...

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Microbial invasion of the Caribbean by an Indo-Pacific coral zooxanthella [Ecology]

16-Jun-2015 | D. Tye Pettay; Drew C. Wham; Robin T. Smith; Roberto Iglesias-Prieto; Todd C. LaJeunesse, Proceedings of the National Academy of Sciences current issue, 2015

Human-induced environmental changes have ushered in the rapid decline of coral reef ecosystems, particularly by disrupting the symbioses between reef-building corals and their photosymbionts. However, escalating stressful conditions enable some symbionts to thrive as opportunists. We present ...

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