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441 Newest Publications in proceedings of the national academy of sciences current issue

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Is BOK required for apoptosis induced by endoplasmic reticulum stress? [Biological Sciences]

02-Feb-2016 | Yuniel Fernandez-Marrero; Francine Ke; Nohemy Echeverry; Philippe Bouillet; Daniel Bachmann; Andreas Strasser; Thoma ..., Proceedings of the National Academy of Sciences current issue, 2016

The B-cell lymphoma 2 (BCL-2)-related ovarian killer (BOK) shares sequence homology with the proapoptotic BCL-2 family members BAX and BAK. However, Bok−/− cells are not protected from classic apoptotic triggers and evidence for a proapoptotic role of BOK is derived mostly from overexpression ...

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Reply to Fernandez-Marrero et al.: Role of BOK at the intersection of endoplasmic reticulum stress and apoptosis regulation [Biological Sciences]

02-Feb-2016 | Marcos A. Carpio; Michael Michaud; Wenping Zhou; Jill K. Fisher; Loren D. Walensky; Samuel G. Katz, Proceedings of the National Academy of Sciences current issue, 2016

The B-cell lymphoma 2 (BCL-2) ovarian killer (BOK) is an intriguing BCL-2 family protein with highest homology to the multidomain executioner proteins BAX and BAK, yet its role in apoptosis regulation has been questionable because of the reported absence of phenotypic findings in Bok−/− mice (1). ...

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A trilogy of glucocorticoid receptor actions [Pharmacology]

02-Feb-2016 | Chek Kun Tan; Walter Wahli, Proceedings of the National Academy of Sciences current issue, 2016

Glucocorticoids (GCs) belong to a class of endogenous, stress-stimulated steroid hormones found in vertebrates (e.g., cortisol in humans and corticosterone in rodents); they have wide ranging physiologic effects capable of impacting metabolism, immunity, development, stress, cognition, and ...

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Activation of integrin {alpha}5 mediated by flow requires its translocation to membrane lipid rafts in vascular endothelial cells [Physiology]

19-Jan-2016 | Xiaoli Sun; Yi Fu; Mingxia Gu; Lu Zhang; Dan Li; Hongliang Li; Shu Chien; John Y.-J. Shyy; Yi Zhu, Proceedings of the National Academy of Sciences current issue, 2016

Local flow patterns determine the uneven distribution of atherosclerotic lesions. Membrane lipid rafts and integrins are crucial for shear stress-regulated endothelial function. In this study, we investigate the role of lipid rafts and integrin α5 in regulating the inflammatory response in ...

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Properties of the shear stress peak radiated ahead of rapidly accelerating rupture fronts that mediate frictional slip [Physics]

19-Jan-2016 | Ilya Svetlizky; Daniel Pino Muñoz; Mathilde Radiguet; David S. Kammer; Jean-François Molinari; Jay Fineberg, Proceedings of the National Academy of Sciences current issue, 2016

We study rapidly accelerating rupture fronts at the onset of frictional motion by performing high-temporal-resolution measurements of both the real contact area and the strain fields surrounding the propagating rupture tip. We observe large-amplitude and localized shear stress peaks that precede ...

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Calcium-dependent oligomerization of CAR proteins at cell membrane modulates ABA signaling [Plant Biology]

19-Jan-2016 | Maira Diaz; Maria Jose Sanchez-Barrena; Juana Maria Gonzalez-Rubio; Lesia Rodriguez; Daniel Fernandez; Regina Antoni ..., Proceedings of the National Academy of Sciences current issue, 2016

Regulation of ion transport in plants is essential for cell function. Abiotic stress unbalances cell ion homeostasis, and plants tend to readjust it, regulating membrane transporters and channels. The plant hormone abscisic acid (ABA) and the second messenger Ca2+ are central in such processes, ...

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A cell wall damage response mediated by a sensor kinase/response regulator pair enables beta-lactam tolerance [Microbiology]

12-Jan-2016 | Tobias Dörr; Laura Alvarez; Fernanda Delgado; Brigid M. Davis; Felipe Cava; Matthew K. Waldor, Proceedings of the National Academy of Sciences current issue, 2016

The bacterial cell wall is critical for maintenance of cell shape and survival. Following exposure to antibiotics that target enzymes required for cell wall synthesis, bacteria typically lyse. Although several cell envelope stress response systems have been well described, there is little ...

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An inhibitor of HIV-1 protease modulates constitutive eIF2{alpha} dephosphorylation to trigger a specific integrated stress response [Biochemistry]

12-Jan-2016 | Aude De Gassart; Bojan Bujisic; Léa Zaffalon; Laurent A. Decosterd; Antonia Di Micco; Gianluca Frera; Rémy Tallant; ..., Proceedings of the National Academy of Sciences current issue, 2016

Inhibitors of the HIV aspartyl protease [HIV protease inhibitors (HIV-PIs)] are the cornerstone of treatment for HIV. Beyond their well-defined antiretroviral activity, these drugs have additional effects that modulate cell viability and homeostasis. However, little is known about the ...

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Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy [Medical Sciences]

05-Jan-2016 | Christina H. Eng; Zuncai Wang; Diane Tkach; Lourdes Toral-Barza; Savuth Ugwonali; Shanming Liu; Stephanie L. Fitzger ..., Proceedings of the National Academy of Sciences current issue, 2016

Macroautophagy is a key stress-response pathway that can suppress or promote tumorigenesis depending on the cellular context. Notably, Kirsten rat sarcoma (KRAS)-driven tumors have been reported to rely on macroautophagy for growth and survival, suggesting a potential therapeutic approach of ...

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Preserving neuroplasticity: Role of glucocorticoids and neurotrophins via phosphorylation [Neuroscience]

22-Dec-2015 | Bruce S. McEwen, Proceedings of the National Academy of Sciences current issue, 2015

The interaction between neurotrophins and glucocorticoids has been at the center of studies of neuroplasticity in stress-related disorders for several decades (1). The report in PNAS by Arango-Lievano et al. (2) shows that brain-derived neurotrophic factor (BDNF) facilitates glucocorticoid ...

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