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281 Newest Publications in proceedings of the national academy of sciences current issue
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matching the following criteria
Arabidopsis nanodomain-delimited ABA signaling pathway regulates the anion channel SLAH3 [Plant Biology]
14-05-2013 | Fatih Demir; Claudia Horntrich; Jörg O. Blachutzik; Sönke Scherzer; Yvonne Reinders; Sylwia Kierszniowska; Waltraud ..., Proceedings of the National Academy of Sciences current issue, 2013
The phytohormone abscisic acid (ABA) plays a key role in the plant response to drought stress. Hence, ABA-dependent gene transcription and ion transport is regulated by a variety of protein kinases and phosphatases. However, the nature of the membrane-delimited ABA signal transduction steps ...
Differential targeting of brain stress circuits with a selective glucocorticoid receptor modulator [Neuroscience]
07-05-2013 | Ioannis Zalachoras; René Houtman; Erika Atucha; Rene Devos; Ans M. I. Tijssen; Pu Hu; Peter M. Lockey; Nicole A. Dat ..., Proceedings of the National Academy of Sciences current issue, 2013
Glucocorticoid receptor (GR) antagonism may be of considerable therapeutic value in stress-related psychopathology such as depression. However, blockade of all GR-dependent processes in the brain will lead to unnecessary and even counteractive effects, such as elevated endogenous cortisol ...
Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy [Cell Biology]
23-04-2013 | Yonghua Yang; Warren Fiskus; Bao Yong; Peter Atadja; Yoshinori Takahashi; Tej K. Pandita; Hong-Gang Wang; Kapil N. B ..., Proceedings of the National Academy of Sciences current issue, 2013
Autophagy is a stress-induced catabolic process in which cytoplasmic components, sequestered in double-membrane autophagic vesicles (AVs) or autophagosomes, are delivered to lysosomes for degradation and recycling [Kroemer G, Mariño G, Levine B (2010) Mol Cell 40(2):280–293]. Activity of the ...
Candidate tumor suppressor BTG3 maintains genomic stability by promoting Lys63-linked ubiquitination and activation of the checkpoint kinase CHK1 [Cell Biology]
09-04-2013 | Yu-Che Cheng; Tsong-Yu Lin; Sheau-Yann Shieh, Proceedings of the National Academy of Sciences current issue, 2013
B-cell translocation gene 3 (BTG3) is a member of the antiproliferative BTG/ Transducer of ErbB2 gene family and is induced by genotoxic stress in a p53- and Checkpoint kinase 1 (CHK1)-dependent manner. Down-regulation of BTG3 has been observed in human cancers, suggesting that it plays an ...
Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1 [Chemistry]
02-04-2013 | Andreas H. Ludewig; Yevgeniy Izrayelit; Donha Park; Rabia U. Malik; Anna Zimmermann; Parag Mahanti; Bennett W. Fox; ..., Proceedings of the National Academy of Sciences current issue, 2013
Lifespan in Caenorhabditis elegans, Drosophila, and mice is regulated by conserved signaling networks, including the insulin/insulin-like growth factor 1 (IGF-1) signaling cascade and pathways depending on sirtuins, a family of NAD+-dependent deacetylases. Small molecules such as resveratrol ...
Molecular mechanism of quinone signaling mediated through S-quinonization of a YodB family repressor QsrR [Biochemistry]
26-03-2013 | Quanjiang Ji; Liang Zhang; Marcus B. Jones; Fei Sun; Xin Deng; Haihua Liang; Hoonsik Cho; Pedro Brugarolas; Yihe N. ..., Proceedings of the National Academy of Sciences current issue, 2013
Quinone molecules are intracellular electron-transport carriers, as well as critical intra- and extracellular signals. However, transcriptional regulation of quinone signaling and its molecular basis are poorly understood. Here, we identify a thiol-stress-sensing regulator YodB family ...
O-GlcNAc transferase (OGT) as a placental biomarker of maternal stress and reprogramming of CNS gene transcription in development [Neuroscience]
26-03-2013 | Christopher L. Howerton; Christopher P. Morgan; David B. Fischer; Tracy L. Bale, Proceedings of the National Academy of Sciences current issue, 2013
Maternal stress is a key risk factor for neurodevelopmental disorders, including schizophrenia and autism, which often exhibit a sex bias in rates of presentation, age of onset, and symptom severity. The placenta is an endocrine tissue that functions as an important mediator in responding to ...
Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains [Cell Biology]
19-03-2013 | Romain Volmer; Kattria van der Ploeg; David Ron, Proceedings of the National Academy of Sciences current issue, 2013
Endoplasmic reticulum (ER) stress sensors use a related luminal domain to monitor the unfolded protein load and convey the signal to downstream effectors, signaling an unfolded protein response (UPR) that maintains compartment-specific protein folding homeostasis. Surprisingly, perturbation ...
PERK/eIF2{alpha} signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS [Cell Biology]
19-03-2013 | Kasper M. Rouschop; Ludwig J. Dubois; Tom G. Keulers; Twan van den Beucken; Philippe Lambin; Johan Bussink; Albert J ..., Proceedings of the National Academy of Sciences current issue, 2013
Hypoxia is a common feature of tumors and an important contributor to malignancy and treatment resistance. The ability of tumor cells to survive hypoxic stress is mediated in part by hypoxia-inducible factor (HIF)-dependent transcriptional responses. More severe hypoxia activates ...
Arabidopsis AHP2, AHP3, and AHP5 histidine phosphotransfer proteins function as redundant negative regulators of drought stress response [Plant Biology]
19-03-2013 | Rie Nishiyama; Yasuko Watanabe; Marco A. Leyva-Gonzalez; Chien Van Ha; Yasunari Fujita; Maho Tanaka; Motoaki Seki; K ..., Proceedings of the National Academy of Sciences current issue, 2013
Cytokinin is an essential phytohormone controlling various biological processes, including environmental stress responses. In Arabidopsis, although the cytokinin (CK)-related phosphorelay—consisting of three histidine kinases, five histidine phosphotransfer proteins (AHPs), and a number of ...
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