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403 Newest Publications in proceedings of the national academy of sciences current issue

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Endothelin receptor B, a candidate gene from human studies at high altitude, improves cardiac tolerance to hypoxia in genetically engineered heterozygote mice [Genetics]

18-Aug-2015 | Tsering Stobdan; Dan Zhou; Eilleen Ao-Ieong; Daniel Ortiz; Roy Ronen; Iain Hartley; Zhuohui Gan; Andrew D. McCulloch ..., Proceedings of the National Academy of Sciences current issue, 2015

To better understand human adaptation to stress, and in particular to hypoxia, we took advantage of one of nature’s experiments at high altitude (HA) and studied Ethiopians, a population that is well-adapted to HA hypoxic stress. Using whole-genome sequencing, we discovered that EDNRB (Endothelin ...

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At14a-Like1 participates in membrane-associated mechanisms promoting growth during drought in Arabidopsis thaliana [Plant Biology]

18-Aug-2015 | M. Nagaraj Kumar; Yi-Fang Hsieh; Paul E. Verslues, Proceedings of the National Academy of Sciences current issue, 2015

Limited knowledge of how plants regulate their growth and metabolism in response to drought and reduced soil water potential has impeded efforts to improve stress tolerance. Increased expression of the membrane-associated protein At14a-like1 (AFL1) led to increased growth and accumulation of the ...

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Reactive oxygen species signal chloroplasts to extend themselves [Plant Biology]

11-Aug-2015 | Maureen R. Hanson, Proceedings of the National Academy of Sciences current issue, 2015

When Sam Wildman’s group first reported his phase-contrast microscopic observations of chloroplast tubular extensions in 1962 (1), he was greeted with skepticism by some plant biologists, who dismissed his findings of membrane protrusions as artifacts of stress caused by long observation of leaf ...

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Stress controls the mechanics of collagen networks [Physics]

04-Aug-2015 | Albert James Licup; Stefan Münster; Abhinav Sharma; Michael Sheinman; Louise M. Jawerth; Ben Fabry; David A. Weitz; ..., Proceedings of the National Academy of Sciences current issue, 2015

Collagen is the main structural and load-bearing element of various connective tissues, where it forms the extracellular matrix that supports cells. It has long been known that collagenous tissues exhibit a highly nonlinear stress–strain relationship, although the origins of this nonlinearity ...

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Heterogeneous binding of the SH3 client protein to the DnaK molecular chaperone [Biophysics and Computational Biology]

04-Aug-2015 | Jung Ho Lee; Dongyu Zhang; Christopher Hughes; Yusuke Okuno; Ashok Sekhar; Silvia Cavagnero, Proceedings of the National Academy of Sciences current issue, 2015

The molecular chaperone heat shock protein 70 (Hsp70) plays a vital role in cellular processes, including protein folding and assembly, and helps prevent aggregation under physiological and stress-related conditions. Although the structural changes undergone by full-length client proteins upon ...

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Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart [Physiology]

21-Jul-2015 | Tyler P. Rasmussen; Yuejin Wu; Mei-ling A. Joiner; Olha M. Koval; Nicholas R. Wilson; Elizabeth D. Luczak; Qinchuan ..., Proceedings of the National Academy of Sciences current issue, 2015

Myocardial mitochondrial Ca2+ entry enables physiological stress responses but in excess promotes injury and death. However, tissue-specific in vivo systems for testing the role of mitochondrial Ca2+ are lacking. We developed a mouse model with myocardial delimited transgenic expression of a ...

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Endoplasmic reticulum stress in the peripheral nervous system is a significant driver of neuropathic pain [Medical Sciences]

21-Jul-2015 | Bora Inceoglu; Ahmed Bettaieb; Carlos A. Trindade da Silva; Kin Sing Stephen Lee; Fawaz G. Haj; Bruce D. Hammock, Proceedings of the National Academy of Sciences current issue, 2015

Despite intensive effort and resulting gains in understanding the mechanisms underlying neuropathic pain, limited success in therapeutic approaches have been attained. A recently identified, nonchannel, nonneurotransmitter therapeutic target for pain is the enzyme soluble epoxide hydrolase (sEH). ...

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Noradrenergic blockade stabilizes prefrontal activity and enables fear extinction under stress [Neuroscience]

14-Jul-2015 | Paul J. Fitzgerald; Thomas F. Giustino; Jocelyn R. Seemann; Stephen Maren, Proceedings of the National Academy of Sciences current issue, 2015

Stress-induced impairments in extinction learning are believed to sustain posttraumatic stress disorder (PTSD). Noradrenergic signaling may contribute to extinction impairments by modulating medial prefrontal cortex (mPFC) circuits involved in fear regulation. Here we demonstrate that aversive ...

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Osmotic stress induces phosphorylation of histone H3 at threonine 3 in pericentromeric regions of Arabidopsis thaliana [Plant Biology]

07-Jul-2015 | Zhen Wang; Juan Armando Casas-Mollano; Jianping Xu; Jean-Jack M. Riethoven; Chi Zhang; Heriberto Cerutti, Proceedings of the National Academy of Sciences current issue, 2015

Histone phosphorylation plays key roles in stress-induced transcriptional reprogramming in metazoans but its function(s) in land plants has remained relatively unexplored. Here we report that an Arabidopsis mutant defective in At3g03940 and At5g18190, encoding closely related Ser/Thr protein ...

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Political influences on greenhouse gas emissions from US states [Sustainability Science]

07-Jul-2015 | Thomas Dietz; Kenneth A. Frank; Cameron T. Whitley; Jennifer Kelly; Rachel Kelly, Proceedings of the National Academy of Sciences current issue, 2015

Starting at least in the 1970s, empirical work suggested that demographic (population) and economic (affluence) forces are the key drivers of anthropogenic stress on the environment. We evaluate the extent to which politics attenuates the effects of economic and demographic factors on ...

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