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296 Newest Publications in proceedings of the national academy of sciences current issue
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matching the following criteria
Activation of heme biosynthesis by a small molecule that is toxic to fermenting Staphylococcus aureus [Microbiology]
14-05-2013 | Laura A. Mike; Brendan F. Dutter; Devin L. Stauff; Jessica L. Moore; Nicholas P. Vitko; Olusegun Aranmolate; Thomas ..., Proceedings of the National Academy of Sciences current issue, 2013
Staphylococcus aureus is a significant infectious threat to global public health. Acquisition or synthesis of heme is required for S. aureus to capture energy through respiration, but an excess of this critical cofactor is toxic to bacteria. S. aureus employs the heme sensor system (HssRS) to ...
Synthesis of customized petroleum-replica fuel molecules by targeted modification of free fatty acid pools in Escherichia coli [Applied Biological Sciences]
07-05-2013 | Thomas P. Howard; Sabine Middelhaufe; Karen Moore; Christoph Edner; Dagmara M. Kolak; George N. Taylor; David A. Par ..., Proceedings of the National Academy of Sciences current issue, 2013
Biofuels are the most immediate, practical solution for mitigating dependence on fossil hydrocarbons, but current biofuels (alcohols and biodiesels) require significant downstream processing and are not fully compatible with modern, mass-market internal combustion engines. Rather, the ideal ...
Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models [Neuroscience]
07-05-2013 | Louise Hedskog; Catarina Moreira Pinho; Riccardo Filadi; Annica Rönnbäck; Laura Hertwig; Birgitta Wiehager; Pia Lars ..., Proceedings of the National Academy of Sciences current issue, 2013
It is well-established that subcompartments of endoplasmic reticulum (ER) are in physical contact with the mitochondria. These lipid raft-like regions of ER are referred to as mitochondria-associated ER membranes (MAMs), and they play an important role in, for example, lipid synthesis, ...
X-ray snapshots of possible intermediates in the time course of synthesis and degradation of protein-bound Fe4S4 clusters [Chemistry]
30-04-2013 | Yvain Nicolet; Roman Rohac; Lydie Martin; Juan C. Fontecilla-Camps, Proceedings of the National Academy of Sciences current issue, 2013
Fe4S4 clusters are very common versatile prosthetic groups in proteins. Their redox property of being sensitive to O2-induced oxidative damage is, for instance, used by the cell to sense oxygen levels and switch between aerobic and anaerobic metabolisms, as exemplified by the fumarate, ...
Intact sphingomyelin biosynthetic pathway is essential for intracellular transport of influenza virus glycoproteins [Cell Biology]
16-04-2013 | Fikadu G. Tafesse; Sumana Sanyal; Joseph Ashour; Carla P. Guimaraes; Martin Hermansson; Pentti Somerharju; Hidde L. ..., Proceedings of the National Academy of Sciences current issue, 2013
Cells genetically deficient in sphingomyelin synthase-1 (SGMS1) or blocked in their synthesis pharmacologically through exposure to a serine palmitoyltransferase inhibitor (myriocin) show strongly reduced surface display of influenza virus glycoproteins hemagglutinin (HA) and neuraminidase ...
The mitochondrial unfolded protein response activator ATFS-1 protects cells from inhibition of the mevalonate pathway [Cell Biology]
09-04-2013 | Manish Rauthan; Parmida Ranji; Nataly Aguilera Pradenas; Christophe Pitot; Marc Pilon, Proceedings of the National Academy of Sciences current issue, 2013
Statins are cholesterol-lowering drugs that inhibit 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase, the rate-limiting enzyme in the synthesis of cholesterol via the mevalonate pathway. This pathway also produces coenzyme Q (a component of the respiratory chain), dolichols (important for ...
RecA acts as a switch to regulate polymerase occupancy in a moving replication fork [Biochemistry]
02-04-2013 | Chiara Indiani; Meghna Patel; Myron F. Goodman; Mike E. O’Donnell, Proceedings of the National Academy of Sciences current issue, 2013
This report discovers a role of Escherichia coli RecA, the cellular recombinase, in directing the action of several DNA polymerases at the replication fork. Bulk chromosome replication is performed by DNA polymerase (Pol) III. However, E. coli contains translesion synthesis (TLS) Pols II, IV, ...
Thiophene-based covalent organic frameworks [Chemistry]
26-03-2013 | Guillaume H. V. Bertrand; Vladimir K. Michaelis; Ta-Chung Ong; Robert G. Griffin; Mircea Dincă, Proceedings of the National Academy of Sciences current issue, 2013
We report the synthesis and characterization of covalent organic frameworks (COFs) incorporating thiophene-based building blocks. We show that these are amenable to reticular synthesis, and that bent ditopic monomers, such as 2,5-thiophenediboronic acid, are defect-prone building blocks that ...
Synthesis of an extra-large molecular sieve using proton sponges as organic structure-directing agents [Chemistry]
05-03-2013 | Raquel Martínez-Franco; Manuel Moliner; Yifeng Yun; Junliang Sun; Wei Wan; Xiaodong Zou; Avelino Corma, Proceedings of the National Academy of Sciences current issue, 2013
The synthesis of crystalline microporous materials containing large pores is in high demand by industry, especially for the use of these materials as catalysts in chemical processes involving bulky molecules. An extra-large–pore silicoaluminophosphate with 16-ring openings, ITQ-51, has been ...
Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis [Microbiology]
26-02-2013 | Gilad Sivan; Scott E. Martin; Timothy G. Myers; Eugen Buehler; Krysia H. Szymczyk; Pinar Ormanoglu; Bernard Moss, Proceedings of the National Academy of Sciences current issue, 2013
Poxviruses are considered less dependent on host functions than other DNA viruses because of their cytoplasmic site of replication and large genomes, which encode enzymes for DNA and mRNA synthesis. Nevertheless, RNAi screens with two independent human genome-scale libraries have identified ...
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