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320 Newest Publications in proceedings of the national academy of sciences current issue

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Transmembrane domain of surface-exposed outer membrane lipoprotein RcsF is threaded through the lumen of {beta}-barrel proteins [Microbiology]

14-10-2014 | Anna Konovalova; David H. Perlman; Charles E. Cowles; Thomas J. Silhavy, Proceedings of the National Academy of Sciences current issue, 2014

RcsF (regulator of capsule synthesis) is an outer membrane (OM) lipoprotein that functions to sense defects such as changes in LPS. However, LPS is found in the outer leaflet, and RcsF was thought to be tethered to the inner leaflet by its lipidated N terminus, raising the question of how...

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Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4 synthesis by inhibiting a calcium-activated kinase pathway [Medical Sciences]

07-10-2014 | Gabrielle Fredman; Lale Ozcan; Stefano Spolitu; Jason Hellmann; Matthew Spite; Johannes Backs; Ira Tabas, Proceedings of the National Academy of Sciences current issue, 2014

Imbalances between proinflammatory and proresolving mediators can lead to chronic inflammatory diseases. The balance of arachidonic acid-derived mediators in leukocytes is thought to be achieved through intracellular localization of 5-lipoxygenase (5-LOX): nuclear 5-LOX favors the biosynthesis of ...

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Controlled sumoylation of the mevalonate pathway enzyme HMGS-1 regulates metabolism during aging [Genetics]

16-09-2014 | Amir Sapir; Assaf Tsur; Thijs Koorman; Kaitlin Ching; Prashant Mishra; Annabelle Bardenheier; Lisa Podolsky; Ulrike ..., Proceedings of the National Academy of Sciences current issue, 2014

Many metabolic pathways are critically regulated during development and aging but little is known about the molecular mechanisms underlying this regulation. One key metabolic cascade in eukaryotes is the mevalonate pathway. It catalyzes the synthesis of sterol and nonsterol isoprenoids, such as ...

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The role of PI3K/AKT-related PIP5K1{alpha} and the discovery of its selective inhibitor for treatment of advanced prostate cancer [Medical Sciences]

02-09-2014 | Julius Semenas; Andreas Hedblom; Regina R. Miftakhova; Martuza Sarwar; Rikard Larsson; Liliya Shcherbina; Martin E. ..., Proceedings of the National Academy of Sciences current issue, 2014

Nitrogen-containing heterocyclic compounds are an important class of molecules that are commonly used for the synthesis of candidate drugs. Phosphatidylinositol-4-phosphate 5-kinase-α (PIP5Kα) is a lipid kinase, similar to PI3K. However, the role of PIP5K1α in oncogenic processes and the ...

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Diversity-oriented combinatorial biosynthesis of benzenediol lactone scaffolds by subunit shuffling of fungal polyketide synthases [Applied Biological Sciences]

26-08-2014 | Yuquan Xu; Tong Zhou; Shuwei Zhang; Patricia Espinosa-Artiles; Luoyi Wang; Wei Zhang; Min Lin; A. A. Leslie Gunatila ..., Proceedings of the National Academy of Sciences current issue, 2014

Combinatorial biosynthesis aspires to exploit the promiscuity of microbial anabolic pathways to engineer the synthesis of new chemical entities. Fungal benzenediol lactone (BDL) polyketides are important pharmacophores with wide-ranging bioactivities, including heat shock response and immune ...

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Synthesis and scavenging role of furan fatty acids [Microbiology]

19-08-2014 | Rachelle A. S. Lemke; Amelia C. Peterson; Eva C. Ziegelhoffer; Michael S. Westphall; Henrik Tjellström; Joshua J. Co ..., Proceedings of the National Academy of Sciences current issue, 2014

Fatty acids play important functional and protective roles in living systems. This paper reports on the synthesis of a previously unidentified 19 carbon furan-containing fatty acid, 10,13-epoxy-11-methyl-octadecadienoate (9-(3-methyl-5-pentylfuran-2-yl)nonanoic acid) (19Fu-FA), in phospholipids ...

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Synthesis and folding of a mirror-image enzyme reveals ambidextrous chaperone activity [Biochemistry]

12-08-2014 | Matthew T. Weinstock; Michael T. Jacobsen; Michael S. Kay, Proceedings of the National Academy of Sciences current issue, 2014

Mirror-image proteins (composed of d-amino acids) are promising therapeutic agents and drug discovery tools, but as synthesis of larger d-proteins becomes feasible, a major anticipated challenge is the folding of these proteins into their active conformations. In vivo, many large and/or complex ...

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Infants' brain responses to speech suggest Analysis by Synthesis [Neuroscience]

05-08-2014 | Patricia K. Kuhl; Rey R. Ramírez; Alexis Bosseler; Jo-Fu Lotus Lin; Toshiaki Imada, Proceedings of the National Academy of Sciences current issue, 2014

Historic theories of speech perception (Motor Theory and Analysis by Synthesis) invoked listeners’ knowledge of speech production to explain speech perception. Neuroimaging data show that adult listeners activate motor brain areas during speech perception. In two experiments using ...

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Energy conservation by oxidation of formate to carbon dioxide and hydrogen via a sodium ion current in a hyperthermophilic archaeon [Microbiology]

05-08-2014 | Jae Kyu Lim; Florian Mayer; Sung Gyun Kang; Volker Müller, Proceedings of the National Academy of Sciences current issue, 2014

Thermococcus onnurineus NA1 is known to grow by the anaerobic oxidation of formate to CO2 and H2, a reaction that operates near thermodynamic equilibrium. Here we demonstrate that this reaction is coupled to ATP synthesis by a transmembrane ion current. Formate oxidation leads to H+ translocation ...

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Synthesis of bioactive protein hydrogels by genetically encoded SpyTag-SpyCatcher chemistry [Biochemistry]

05-08-2014 | Fei Sun; Wen-Bin Zhang; Alborz Mahdavi; Frances H. Arnold; David A. Tirrell, Proceedings of the National Academy of Sciences current issue, 2014

Protein-based hydrogels have emerged as promising alternatives to synthetic hydrogels for biomedical applications, owing to the precise control of structure and function enabled by protein engineering. Nevertheless, strategies for assembling 3D molecular networks that carry the biological ...

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