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349 Newest Publications in proceedings of the national academy of sciences current issue

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PAB is an assembly chaperone that functions downstream of chaperonin 60 in the assembly of chloroplast ATP synthase coupling factor 1 [Plant Biology]

31-Mar-2015 | Juan Mao; Wei Chi; Min Ouyang; Baoye He; Fan Chen; Lixin Zhang, Proceedings of the National Academy of Sciences current issue, 2015

The chloroplast ATP synthase, a multisubunit complex in the thylakoid membrane, catalyzes the light-driven synthesis of ATP, thereby supplying the energy for carbon fixation during photosynthesis. The chloroplast ATP synthase is composed of both nucleus- and chloroplast-encoded proteins that have ...

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ORMDL orosomucoid-like proteins are degraded by free-cholesterol-loading-induced autophagy [Cell Biology]

24-Mar-2015 | Shuhui Wang; Peggy Robinet; Jonathan D. Smith; Kailash Gulshan, Proceedings of the National Academy of Sciences current issue, 2015

Eukaryotic cells have evolved robust mechanisms to counter excess cholesterol including redistribution of lipids into different compartments and compensatory up-regulation of phospholipid biosynthesis. We demonstrate here that excess cellular cholesterol increased the activity of the endoplasmic ...

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Plant-derived antifungal agent poacic acid targets {beta}-1,3-glucan [Microbiology]

24-Mar-2015 | Jeff S. Piotrowski; Hiroki Okada; Fachuang Lu; Sheena C. Li; Li Hinchman; Ashish Ranjan; Damon L. Smith; Alan J. Hig ..., Proceedings of the National Academy of Sciences current issue, 2015

A rise in resistance to current antifungals necessitates strategies to identify alternative sources of effective fungicides. We report the discovery of poacic acid, a potent antifungal compound found in lignocellulosic hydrolysates of grasses. Chemical genomics using Saccharomyces cerevisiae ...

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Oncogenic fusion protein EWS-FLI1 is a network hub that regulates alternative splicing [Medical Sciences]

17-Mar-2015 | Saravana P. Selvanathan; Garrett T. Graham; Hayriye V. Erkizan; Uta Dirksen; Thanemozhi G. Natarajan; Aleksandra Dak ..., Proceedings of the National Academy of Sciences current issue, 2015

The synthesis and processing of mRNA, from transcription to translation initiation, often requires splicing of intragenic material. The final mRNA composition varies based on proteins that modulate splice site selection. EWS-FLI1 is an Ewing sarcoma (ES) oncoprotein with an interactome that we ...

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Nucleation of metastable aragonite CaCO3 in seawater [Applied Physical Sciences]

17-Mar-2015 | Wenhao Sun; Saivenkataraman Jayaraman; Wei Chen; Kristin A. Persson; Gerbrand Ceder, Proceedings of the National Academy of Sciences current issue, 2015

Predicting the conditions in which a compound adopts a metastable structure when it crystallizes out of solution is an unsolved and fundamental problem in materials synthesis, and one which, if understood and harnessed, could enable the rational design of synthesis pathways toward or away from ...

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Spray-combustion synthesis: Efficient solution route to high-performance oxide transistors [Chemistry]

17-Mar-2015 | Xinge Yu; Jeremy Smith; Nanjia Zhou; Li Zeng; Peijun Guo; Yu Xia; Ana Alvarez; Stefano Aghion; Hui Lin; Junsheng Yu; ..., Proceedings of the National Academy of Sciences current issue, 2015

Metal-oxide (MO) semiconductors have emerged as enabling materials for next generation thin-film electronics owing to their high carrier mobilities, even in the amorphous state, large-area uniformity, low cost, and optical transparency, which are applicable to flat-panel displays, flexible ...

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Nonsense suppression by near-cognate tRNAs employs alternative base pairing at codon positions 1 and 3 [Genetics]

10-Mar-2015 | Bijoyita Roy; John D. Leszyk; David A. Mangus; Allan Jacobson, Proceedings of the National Academy of Sciences current issue, 2015

Premature termination codons (PTCs) in an mRNA ORF inactivate gene function by causing production of a truncated protein and destabilization of the mRNA. Readthrough of a PTC allows ribosomal A-site insertion of a near-cognate tRNA, leading to synthesis of a full-length protein from otherwise ...

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RING finger protein 121 facilitates the degradation and membrane localization of voltage-gated sodium channels [Neuroscience]

03-Mar-2015 | Kazutoyo Ogino; Sean E. Low; Kenta Yamada; Louis Saint-Amant; Weibin Zhou; Akira Muto; Kazuhide Asakawa; Junichi Nak ..., Proceedings of the National Academy of Sciences current issue, 2015

Following their synthesis in the endoplasmic reticulum (ER), voltage-gated sodium channels (NaV) are transported to the membranes of excitable cells, where they often cluster, such as at the axon initial segment of neurons. Although the mechanisms by which NaV channels form and maintain clusters ...

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In vitro reconstitution of indolmycin biosynthesis reveals the molecular basis of oxazolinone assembly [Biochemistry]

03-Mar-2015 | Yi-Ling Du; Lona M. Alkhalaf; Katherine S. Ryan, Proceedings of the National Academy of Sciences current issue, 2015

The bacterial tryptophanyl–tRNA synthetase inhibitor indolmycin features a unique oxazolinone heterocycle whose biogenetic origins have remained obscure for over 50 years. Here we identify and characterize the indolmycin biosynthetic pathway, using systematic in vivo gene inactivation, in vitro ...

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Greedy scheduling of cellular self-replication leads to optimal doubling times with a log-Frechet distribution [Physics]

24-Feb-2015 | Rami Pugatch, Proceedings of the National Academy of Sciences current issue, 2015

Bacterial self-replication is a complex process composed of many de novo synthesis steps catalyzed by a myriad of molecular processing units, e.g., the transcription–translation machinery, metabolic enzymes, and the replisome. Successful completion of all production tasks requires a schedule—a ...

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