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327 Newest Publications in proceedings of the national academy of sciences current issue

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Rational design and synthesis of an orally bioavailable peptide guided by NMR amide temperature coefficients [Biophysics and Computational Biology]

09-12-2014 | Conan K. Wang; Susan E. Northfield; Barbara Colless; Stephanie Chaousis; Ingrid Hamernig; Rink-Jan Lohman; Daniel S. ..., Proceedings of the National Academy of Sciences current issue, 2014

Enhancing the oral bioavailability of peptide drug leads is a major challenge in drug design. As such, methods to address this challenge are highly sought after by the pharmaceutical industry. Here, we propose a strategy to identify appropriate amides for N-methylation using temperature ...

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Interacting cytoplasmic loops of subunits a and c of Escherichia coli F1F0 ATP synthase gate H+ transport to the cytoplasm [Biochemistry]

25-11-2014 | P. Ryan Steed; Kaitlin A. Kraft; Robert H. Fillingame, Proceedings of the National Academy of Sciences current issue, 2014

H+-transporting F1F0 ATP synthase catalyzes the synthesis of ATP via coupled rotary motors within F0 and F1. H+ transport at the subunit a–c interface in transmembranous F0 drives rotation of a cylindrical c10 oligomer within the membrane, which is coupled to rotation of subunit γ within the α3β3 ...

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Amino acid modified Ni catalyst exhibits reversible H2 oxidation/production over a broad pH range at elevated temperatures [Chemistry]

18-11-2014 | Arnab Dutta; Daniel L. DuBois; John A. S. Roberts; Wendy J. Shaw, Proceedings of the National Academy of Sciences current issue, 2014

Hydrogenases interconvert H2 and protons at high rates and with high energy efficiencies, providing inspiration for the development of molecular catalysts. Studies designed to determine how the protein scaffold can influence a catalytically active site have led to the synthesis of amino acid ...

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Arabidopsis protein arginine methyltransferase 3 is required for ribosome biogenesis by affecting precursor ribosomal RNA processing [Plant Biology]

11-11-2014 | Runlai Hang; Chunyan Liu; Ayaz Ahmad; Yong Zhang; Falong Lu; Xiaofeng Cao, Proceedings of the National Academy of Sciences current issue, 2014

Ribosome biogenesis is a fundamental and tightly regulated cellular process, including synthesis, processing, and assembly of rRNAs with ribosomal proteins. Protein arginine methyltransferases (PRMTs) have been implicated in many important biological processes, such as ribosome biogenesis. Two ...

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Activity-dependent PI(3,5)P2 synthesis controls AMPA receptor trafficking during synaptic depression [Neuroscience]

11-11-2014 | Amber J. McCartney; Sergey N. Zolov; Emily J. Kauffman; Yanling Zhang; Bethany S. Strunk; Lois S. Weisman; Michael A ..., Proceedings of the National Academy of Sciences current issue, 2014

Dynamic regulation of phosphoinositide lipids (PIPs) is crucial for diverse cellular functions, and, in neurons, PIPs regulate membrane trafficking events that control synapse function. Neurons are particularly sensitive to the levels of the low abundant PIP, phosphatidylinositol 3,5-bisphosphate ...

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Sequence selectivity of macrolide-induced translational attenuation [Biochemistry]

28-10-2014 | Amber R. Davis; David W. Gohara; Mee-Ngan F. Yap, Proceedings of the National Academy of Sciences current issue, 2014

The prevailing “plug-in-the-bottle” model suggests that macrolide antibiotics inhibit translation by binding inside the ribosome tunnel and indiscriminately arresting the elongation of every nascent polypeptide after the synthesis of six to eight amino acids. To test this model, we performed a ...

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CMG helicase and DNA polymerase ϵ form a functional 15-subunit holoenzyme for eukaryotic leading-strand DNA replication [Biochemistry]

28-10-2014 | Lance D. Langston; Dan Zhang; Olga Yurieva; Roxana E. Georgescu; Jeff Finkelstein; Nina Y. Yao; Chiara Indiani; Mike ..., Proceedings of the National Academy of Sciences current issue, 2014

DNA replication in eukaryotes is asymmetric, with separate DNA polymerases (Pol) dedicated to bulk synthesis of the leading and lagging strands. Pol α/primase initiates primers on both strands that are extended by Pol ε on the leading strand and by Pol δ on the lagging strand. The CMG ...

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Transmembrane domain of surface-exposed outer membrane lipoprotein RcsF is threaded through the lumen of {beta}-barrel proteins [Microbiology]

14-10-2014 | Anna Konovalova; David H. Perlman; Charles E. Cowles; Thomas J. Silhavy, Proceedings of the National Academy of Sciences current issue, 2014

RcsF (regulator of capsule synthesis) is an outer membrane (OM) lipoprotein that functions to sense defects such as changes in LPS. However, LPS is found in the outer leaflet, and RcsF was thought to be tethered to the inner leaflet by its lipidated N terminus, raising the question of how...

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Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4 synthesis by inhibiting a calcium-activated kinase pathway [Medical Sciences]

07-10-2014 | Gabrielle Fredman; Lale Ozcan; Stefano Spolitu; Jason Hellmann; Matthew Spite; Johannes Backs; Ira Tabas, Proceedings of the National Academy of Sciences current issue, 2014

Imbalances between proinflammatory and proresolving mediators can lead to chronic inflammatory diseases. The balance of arachidonic acid-derived mediators in leukocytes is thought to be achieved through intracellular localization of 5-lipoxygenase (5-LOX): nuclear 5-LOX favors the biosynthesis of ...

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Controlled sumoylation of the mevalonate pathway enzyme HMGS-1 regulates metabolism during aging [Genetics]

16-09-2014 | Amir Sapir; Assaf Tsur; Thijs Koorman; Kaitlin Ching; Prashant Mishra; Annabelle Bardenheier; Lisa Podolsky; Ulrike ..., Proceedings of the National Academy of Sciences current issue, 2014

Many metabolic pathways are critically regulated during development and aging but little is known about the molecular mechanisms underlying this regulation. One key metabolic cascade in eukaryotes is the mevalonate pathway. It catalyzes the synthesis of sterol and nonsterol isoprenoids, such as ...

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