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394 Newest Publications in proceedings of the national academy of sciences current issue

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Overcoming heterologous protein interdependency to optimize P450-mediated Taxol precursor synthesis in Escherichia coli [Applied Biological Sciences]

22-Mar-2016 | Bradley Walters Biggs; Chin Giaw Lim; Kristen Sagliani; Smriti Shankar; Gregory Stephanopoulos; Marjan De Mey; Paray ..., Proceedings of the National Academy of Sciences current issue, 2016

Recent advances in metabolic engineering have demonstrated the potential to exploit biological chemistry for the synthesis of complex molecules. Much of the progress to date has leveraged increasingly precise genetic tools to control the transcription and translation of enzymes for superior ...

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Novel genomic island modifies DNA with 7-deazaguanine derivatives [Biochemistry]

15-Mar-2016 | Jennifer J. Thiaville; Stefanie M. Kellner; Yifeng Yuan; Geoffrey Hutinet; Patrick C. Thiaville; Watthanachai Jumpat ..., Proceedings of the National Academy of Sciences current issue, 2016

The discovery of ∼20-kb gene clusters containing a family of paralogs of tRNA guanosine transglycosylase genes, called tgtA5, alongside 7-cyano-7-deazaguanine (preQ0) synthesis and DNA metabolism genes, led to the hypothesis that 7-deazaguanine derivatives are inserted in DNA. This was ...

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One-step catalytic asymmetric synthesis of all-syn deoxypropionate motif from propylene: Total synthesis of (2R,4R,6R,8R)-2,4,6,8-tetramethyldecanoic acid [Chemistry]

15-Mar-2016 | Yusuke Ota; Toshiki Murayama; Kyoko Nozaki, Proceedings of the National Academy of Sciences current issue, 2016

In nature, many complex structures are assembled from simple molecules by a series of tailored enzyme-catalyzed reactions. One representative example is the deoxypropionate motif, an alternately methylated alkyl chain containing multiple stereogenic centers, which is biosynthesized by a series of ...

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Solar photothermochemical alkane reverse combustion [Chemistry]

08-Mar-2016 | Wilaiwan Chanmanee; Mohammad Fakrul Islam; Brian H. Dennis; Frederick M. MacDonnell, Proceedings of the National Academy of Sciences current issue, 2016

A one-step, gas-phase photothermocatalytic process for the synthesis of hydrocarbons, including liquid alkanes, aromatics, and oxygenates, with carbon numbers (Cn) up to C13, from CO2 and water is demonstrated in a flow photoreactor operating at elevated temperatures (180–200 °C) and pressures ...

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Load-dependent destabilization of the {gamma}-rotor shaft in FOF1 ATP synthase revealed by hydrogen/deuterium-exchange mass spectrometry [Biophysics and Computational Biology]

01-Mar-2016 | Siavash Vahidi; Yumin Bi; Stanley D. Dunn; Lars Konermann, Proceedings of the National Academy of Sciences current issue, 2016

FoF1 is a membrane-bound molecular motor that uses proton-motive force (PMF) to drive the synthesis of ATP from ADP and Pi. Reverse operation generates PMF via ATP hydrolysis. Catalysis in either direction involves rotation of the γε shaft that connects the α3β3 head and the membrane-anchored cn ...

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Mechanism of a cytosolic O-glycosyltransferase essential for the synthesis of a bacterial adhesion protein [Biochemistry]

01-Mar-2016 | Yu Chen; Ravin Seepersaud; Barbara A. Bensing; Paul M. Sullam; Tom A. Rapoport, Proceedings of the National Academy of Sciences current issue, 2016

O-glycosylation of Ser and Thr residues is an important process in all organisms, which is only poorly understood. Such modification is required for the export and function of adhesin proteins that mediate the attachment of pathogenic Gram-positive bacteria to host cells. Here, we have analyzed ...

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Axons provide the secretory machinery for trafficking of voltage-gated sodium channels in peripheral nerve [Cell Biology]

16-Feb-2016 | Carolina González; José Cánovas; Javiera Fresno; Eduardo Couve; Felipe A. Court; Andrés Couve, Proceedings of the National Academy of Sciences current issue, 2016

The regulation of the axonal proteome is key to generate and maintain neural function. Fast and slow axoplasmic waves have been known for decades, but alternative mechanisms to control the abundance of axonal proteins based on local synthesis have also been identified. The presence of the ...

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Structure of NDP-forming Acetyl-CoA synthetase ACD1 reveals a large rearrangement for phosphoryl transfer [Biochemistry]

02-Feb-2016 | Renato H.-J. Weiße; Annette Faust; Marcel Schmidt; Peter Schönheit; Axel J. Scheidig, Proceedings of the National Academy of Sciences current issue, 2016

The NDP-forming acyl-CoA synthetases (ACDs) catalyze the conversion of various CoA thioesters to the corresponding acids, conserving their chemical energy in form of ATP. The ACDs are the major energy-conserving enzymes in sugar and peptide fermentation of hyperthermophilic archaea. They are ...

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Hyaluronan synthesis is necessary for autoreactive T-cell trafficking, activation, and Th1 polarization [Immunology and Inflammation]

02-Feb-2016 | Hedwich F. Kuipers; Mary Rieck; Irina Gurevich; Nadine Nagy; Manish J. Butte; Robert S. Negrin; Thomas N. Wight; Law ..., Proceedings of the National Academy of Sciences current issue, 2016

The extracellular matrix polysaccharide hyaluronan (HA) accumulates at sites of autoimmune inflammation, including white matter lesions in multiple sclerosis (MS), but its functional importance in pathogenesis is unclear. We have evaluated the impact of 4-methylumbelliferone (4-MU), an oral ...

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Discovery of RNA splicing and genes in pieces [Biochemistry]

26-Jan-2016 | Arnold J. Berk, Proceedings of the National Academy of Sciences current issue, 2016

The Problem: Short-Lived Heterogeneous Nuclear RNA During the 1960s and 1970s, there was a major conundrum in eukaryotic molecular biology regarding the synthesis of mRNA in animal cells. Pulse and pulse-chase radio-labeling experiments with tritiated uridine had shown that a large fraction of ...

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