My watch list
my.chemeurope.com  
Login  

325 Newest Publications in proceedings of the national academy of sciences current issue

rss
matching the following criteria

Amino acid modified Ni catalyst exhibits reversible H2 oxidation/production over a broad pH range at elevated temperatures [Chemistry]

18-11-2014 | Arnab Dutta; Daniel L. DuBois; John A. S. Roberts; Wendy J. Shaw, Proceedings of the National Academy of Sciences current issue, 2014

Hydrogenases interconvert H2 and protons at high rates and with high energy efficiencies, providing inspiration for the development of molecular catalysts. Studies designed to determine how the protein scaffold can influence a catalytically active site have led to the synthesis of amino acid ...

more

Arabidopsis protein arginine methyltransferase 3 is required for ribosome biogenesis by affecting precursor ribosomal RNA processing [Plant Biology]

11-11-2014 | Runlai Hang; Chunyan Liu; Ayaz Ahmad; Yong Zhang; Falong Lu; Xiaofeng Cao, Proceedings of the National Academy of Sciences current issue, 2014

Ribosome biogenesis is a fundamental and tightly regulated cellular process, including synthesis, processing, and assembly of rRNAs with ribosomal proteins. Protein arginine methyltransferases (PRMTs) have been implicated in many important biological processes, such as ribosome biogenesis. Two ...

more

Activity-dependent PI(3,5)P2 synthesis controls AMPA receptor trafficking during synaptic depression [Neuroscience]

11-11-2014 | Amber J. McCartney; Sergey N. Zolov; Emily J. Kauffman; Yanling Zhang; Bethany S. Strunk; Lois S. Weisman; Michael A ..., Proceedings of the National Academy of Sciences current issue, 2014

Dynamic regulation of phosphoinositide lipids (PIPs) is crucial for diverse cellular functions, and, in neurons, PIPs regulate membrane trafficking events that control synapse function. Neurons are particularly sensitive to the levels of the low abundant PIP, phosphatidylinositol 3,5-bisphosphate ...

more

Sequence selectivity of macrolide-induced translational attenuation [Biochemistry]

28-10-2014 | Amber R. Davis; David W. Gohara; Mee-Ngan F. Yap, Proceedings of the National Academy of Sciences current issue, 2014

The prevailing “plug-in-the-bottle” model suggests that macrolide antibiotics inhibit translation by binding inside the ribosome tunnel and indiscriminately arresting the elongation of every nascent polypeptide after the synthesis of six to eight amino acids. To test this model, we performed a ...

more

CMG helicase and DNA polymerase ϵ form a functional 15-subunit holoenzyme for eukaryotic leading-strand DNA replication [Biochemistry]

28-10-2014 | Lance D. Langston; Dan Zhang; Olga Yurieva; Roxana E. Georgescu; Jeff Finkelstein; Nina Y. Yao; Chiara Indiani; Mike ..., Proceedings of the National Academy of Sciences current issue, 2014

DNA replication in eukaryotes is asymmetric, with separate DNA polymerases (Pol) dedicated to bulk synthesis of the leading and lagging strands. Pol α/primase initiates primers on both strands that are extended by Pol ε on the leading strand and by Pol δ on the lagging strand. The CMG ...

more

Transmembrane domain of surface-exposed outer membrane lipoprotein RcsF is threaded through the lumen of {beta}-barrel proteins [Microbiology]

14-10-2014 | Anna Konovalova; David H. Perlman; Charles E. Cowles; Thomas J. Silhavy, Proceedings of the National Academy of Sciences current issue, 2014

RcsF (regulator of capsule synthesis) is an outer membrane (OM) lipoprotein that functions to sense defects such as changes in LPS. However, LPS is found in the outer leaflet, and RcsF was thought to be tethered to the inner leaflet by its lipidated N terminus, raising the question of how...

more

Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4 synthesis by inhibiting a calcium-activated kinase pathway [Medical Sciences]

07-10-2014 | Gabrielle Fredman; Lale Ozcan; Stefano Spolitu; Jason Hellmann; Matthew Spite; Johannes Backs; Ira Tabas, Proceedings of the National Academy of Sciences current issue, 2014

Imbalances between proinflammatory and proresolving mediators can lead to chronic inflammatory diseases. The balance of arachidonic acid-derived mediators in leukocytes is thought to be achieved through intracellular localization of 5-lipoxygenase (5-LOX): nuclear 5-LOX favors the biosynthesis of ...

more

Controlled sumoylation of the mevalonate pathway enzyme HMGS-1 regulates metabolism during aging [Genetics]

16-09-2014 | Amir Sapir; Assaf Tsur; Thijs Koorman; Kaitlin Ching; Prashant Mishra; Annabelle Bardenheier; Lisa Podolsky; Ulrike ..., Proceedings of the National Academy of Sciences current issue, 2014

Many metabolic pathways are critically regulated during development and aging but little is known about the molecular mechanisms underlying this regulation. One key metabolic cascade in eukaryotes is the mevalonate pathway. It catalyzes the synthesis of sterol and nonsterol isoprenoids, such as ...

more

The role of PI3K/AKT-related PIP5K1{alpha} and the discovery of its selective inhibitor for treatment of advanced prostate cancer [Medical Sciences]

02-09-2014 | Julius Semenas; Andreas Hedblom; Regina R. Miftakhova; Martuza Sarwar; Rikard Larsson; Liliya Shcherbina; Martin E. ..., Proceedings of the National Academy of Sciences current issue, 2014

Nitrogen-containing heterocyclic compounds are an important class of molecules that are commonly used for the synthesis of candidate drugs. Phosphatidylinositol-4-phosphate 5-kinase-α (PIP5Kα) is a lipid kinase, similar to PI3K. However, the role of PIP5K1α in oncogenic processes and the ...

more

Diversity-oriented combinatorial biosynthesis of benzenediol lactone scaffolds by subunit shuffling of fungal polyketide synthases [Applied Biological Sciences]

26-08-2014 | Yuquan Xu; Tong Zhou; Shuwei Zhang; Patricia Espinosa-Artiles; Luoyi Wang; Wei Zhang; Min Lin; A. A. Leslie Gunatila ..., Proceedings of the National Academy of Sciences current issue, 2014

Combinatorial biosynthesis aspires to exploit the promiscuity of microbial anabolic pathways to engineer the synthesis of new chemical entities. Fungal benzenediol lactone (BDL) polyketides are important pharmacophores with wide-ranging bioactivities, including heat shock response and immune ...

more

Page 1 From 33
Subscribe to e-mail updates relating to your search

You will receive via e-mail the latest search results matching your search criteria. This service is free of charge and can be cancelled at any time.

Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE