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744 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

The Runt-related transcription factor 1 in prostate cancer-associated fibroblasts [Cell Biology]

18-11-2014 | Hilary A. Coller, Proceedings of the National Academy of Sciences current issue, 2014

Although most carcinomas arise from a series of genetic alterations in epithelial cells, cancer is a disease that affects not just the transformed cells themselves, but the entire tissue. During tumor development, reciprocal signaling patterns between the cancer cells and the surrounding tissue ...

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Calcium-mediated histone modifications regulate alternative splicing in cardiomyocytes [Biochemistry]

18-11-2014 | Alok Sharma; Hieu Nguyen; Cuiyu Geng; Melissa N. Hinman; Guangbin Luo; Hua Lou, Proceedings of the National Academy of Sciences current issue, 2014

In cardiomyocytes, calcium is known to control gene expression at the level of transcription, whereas its role in regulating alternative splicing has not been explored. Here we report that, in mouse primary or embryonic stem cell-derived cardiomyocytes, increased calcium levels induce robust and ...

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EGR2 is critical for peripheral naive T-cell differentiation and the T-cell response to influenza [Immunology and Inflammation]

18-11-2014 | Ning Du; Hyokjoon Kwon; Peng Li; Erin E. West; Jangsuk Oh; Wei Liao; Zuxi Yu; Min Ren; Warren J. Leonard, Proceedings of the National Academy of Sciences current issue, 2014

Early growth response 2 (EGR2) transcription factor negatively regulates T-cell activation, in contrast to the positive regulation of this process by EGR1. Here, we unexpectedly found that EGR2 promotes peripheral naïve T-cell differentiation, with delayed T-cell receptor-induced proliferation in ...

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A circadian gene expression atlas in mammals: Implications for biology and medicine [Systems Biology]

11-11-2014 | Ray Zhang; Nicholas F. Lahens; Heather I. Ballance; Michael E. Hughes; John B. Hogenesch, Proceedings of the National Academy of Sciences current issue, 2014

To characterize the role of the circadian clock in mouse physiology and behavior, we used RNA-seq and DNA arrays to quantify the transcriptomes of 12 mouse organs over time. We found 43% of all protein coding genes showed circadian rhythms in transcription somewhere in the body, largely in an ...

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Sensing nerve injury at the axonal ER: Activated Luman/CREB3 serves as a novel axonally synthesized retrograde regeneration signal [Neuroscience]

11-11-2014 | Zhengxin Ying; Vikram Misra; Valerie M. K. Verge, Proceedings of the National Academy of Sciences current issue, 2014

Luman/cAMP response element binding protein 3 is an endoplasmic reticulum (ER) transmembrane basic leucine zipper transcription factor whose mRNA and protein localize to adult sensory axons, the latter with axonal ER components along the axon length. Here we show that axon-derived Luman plays an ...

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p100/I{kappa}B{delta} sequesters and inhibits NF-{kappa}B through kappaBsome formation [Biochemistry]

11-11-2014 | Zhihua Tao; Amanda Fusco; De-Bin Huang; Kushol Gupta; Daniel Young Kim; Carl F. Ware; Gregory D. Van Duyne; Gourisan ..., Proceedings of the National Academy of Sciences current issue, 2014

Degradation of I kappaB (κB) inhibitors is critical to activation of dimeric transcription factors of the NF-κB family. There are two types of IκB inhibitors: the prototypical IκBs (IκBα, IκBβ, and IκBε), which form low-molecular-weight (MW) IκB:NF-κB complexes that are highly stable, and the ...

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DNA supercoiling: A regulatory signal for the {lambda} repressor [Biophysics and Computational Biology]

28-10-2014 | Yue Ding; Carlo Manzo; Geraldine Fulcrand; Fenfei Leng; David Dunlap; Laura Finzi, Proceedings of the National Academy of Sciences current issue, 2014

Topoisomerases, polymerases, and the chirality introduced by the binding of histones or nucleoid-associated proteins affect DNA supercoiling in vivo. However, supercoiling is not just a by-product of DNA metabolism. Supercoiling is an indicator of cell health, it modifies the accessibility of ...

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Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in classical Hodgkin lymphoma [Medical Sciences]

21-10-2014 | Stephan Kreher; M. Amine Bouhlel; Pierre Cauchy; Björn Lamprecht; Shuang Li; Michael Grau; Franziska Hummel; Karl Kö ..., Proceedings of the National Academy of Sciences current issue, 2014

Deregulated transcription factor (TF) activities are commonly observed in hematopoietic malignancies. Understanding tumorigenesis therefore requires determining the function and hierarchical role of individual TFs. To identify TFs central to lymphomagenesis, we identified lymphoma type-specific ...

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KAISO, a critical regulator of p53-mediated transcription of CDKN1A and apoptotic genes [Biochemistry]

21-10-2014 | Dong-In Koh; Dohyun Han; Hoon Ryu; Won-Il Choi; Bu-Nam Jeon; Min-Kyeong Kim; Youngsoo Kim; Jin Young Kim; Lee Parry; ..., Proceedings of the National Academy of Sciences current issue, 2014

An unresolved issue in genotoxic stress response is identification of induced regulatory proteins and how these activate tumor suppressor p53 to determine appropriate cell responses. Transcription factor KAISO was previously described to repress transcription following binding to methylated DNA. ...

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Structural studies on the authentic mumps virus nucleocapsid showing uncoiling by the phosphoprotein [Microbiology]

21-10-2014 | Robert Cox; Adrian Pickar; Shihong Qiu; Jun Tsao; Cynthia Rodenburg; Terje Dokland; Andrew Elson; Biao He; Ming Luo, Proceedings of the National Academy of Sciences current issue, 2014

Mumps virus (MuV) is a highly contagious pathogen, and despite extensive vaccination campaigns, outbreaks continue to occur worldwide. The virus has a negative-sense, single-stranded RNA genome that is encapsidated by the nucleocapsid protein (N) to form the nucleocapsid (NC). NC serves as the ...

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