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653 Newest Publications in proceedings of the national academy of sciences current issue
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matching the following criteria
Surface display of a massively variable lipoprotein by a Legionella diversity-generating retroelement [Microbiology]
14-05-2013 | Diego Arambula; Wenge Wong; Bob A. Medhekar; Huatao Guo; Mari Gingery; Elizabeth Czornyj; Minghsun Liu; Sanghamitra ..., Proceedings of the National Academy of Sciences current issue, 2013
Diversity-generating retroelements (DGRs) are a unique family of retroelements that confer selective advantages to their hosts by facilitating localized DNA sequence evolution through a specialized error-prone reverse transcription process. We characterized a DGR in Legionella pneumophila, an ...
Latency of Epstein-Barr virus is disrupted by gain-of-function mutant cellular AP-1 proteins that preferentially bind methylated DNA [Medical Sciences]
14-05-2013 | Kuan-Ping Yu; Lee Heston; Richard Park; Zhaowei Ding; Ruth Wang’ondu; Henri-Jacques Delecluse; George Miller, Proceedings of the National Academy of Sciences current issue, 2013
ZEBReplication Activator (ZEBRA), a viral basic zipper protein that initiates the Epstein–Barr viral lytic cycle, binds to DNA and activates transcription through heptamer ZEBRA response elements (ZREs) related to AP-1 sites. A component of the biologic action of ZEBRA is attributable to ...
Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1 [Medical Sciences]
14-05-2013 | Lori A. Ramkissoon; Peleg M. Horowitz; Justin M. Craig; Shakti H. Ramkissoon; Benjamin E. Rich; Steven E. Schumacher ..., Proceedings of the National Academy of Sciences current issue, 2013
Pediatric low-grade gliomas (PLGGs) are among the most common solid tumors in children but, apart from BRAF kinase mutations or duplications in specific subclasses, few genetic driver events are known. Diffuse PLGGs comprise a set of uncommon subtypes that exhibit invasive growth and are ...
Holo-TFIID controls the magnitude of a transcription burst and fine-tuning of transcription [Biochemistry]
07-05-2013 | Katie L. Pennington; Sharon K. Marr; Gung-Wei Chirn; Michael T. Marr II, Proceedings of the National Academy of Sciences current issue, 2013
Transcription factor (TF)IID is a central player in activated transcription initiation. Recent evidence suggests that the role and composition of TFIID are more diverse than previously understood. To investigate the effects of changing the composition of TFIID in a simple system, we depleted ...
Structures of complexes comprised of Fischerella transcription factor HetR with Anabaena DNA targets [Biochemistry]
07-05-2013 | Youngchang Kim; Zi Ye; Grazyna Joachimiak; Patrick Videau; Jasmine Young; Kathryn Hurd; Sean M. Callahan; Piotr Gorn ..., Proceedings of the National Academy of Sciences current issue, 2013
HetR is an essential regulator of heterocyst development in cyanobacteria. Many mutations in HetR render Anabaena incapable of nitrogen fixation. The protein binds to a DNA palindrome upstream of hetP and other genes. We have determined the crystal structures of HetR complexed with ...
Hippo-Foxa2 signaling pathway plays a role in peripheral lung maturation and surfactant homeostasis [Developmental Biology]
07-05-2013 | Chaeuk Chung; Tackhoon Kim; Miju Kim; Minchul Kim; Hoogeun Song; Tae-Shin Kim; Eunjeong Seo; Sang-Hee Lee; Hanbyul K ..., Proceedings of the National Academy of Sciences current issue, 2013
Respiratory distress syndrome (RDS), which is induced by insufficient production of surfactant, is the leading cause of mortality in preterm babies. Although several transcription factors are known to be involved in surfactant protein expression, the molecular mechanisms and signaling ...
Histone chaperone FACT action during transcription through chromatin by RNA polymerase II [Biochemistry]
07-05-2013 | Fu-Kai Hsieh; Olga I. Kulaeva; Smita S. Patel; Pamela N. Dyer; Karolin Luger; Danny Reinberg; Vasily M. Studitsky, Proceedings of the National Academy of Sciences current issue, 2013
FACT (facilitates chromatin transcription) is a histone chaperone that promotes chromatin recovery during transcription, with additional roles in cell differentiation. Although several models of the action of FACT during transcription have been proposed, they remain to be experimentally ...
Identification and characterization of a previously undescribed family of sequence-specific DNA-binding domains [Biochemistry]
07-05-2013 | Matthew B. Lohse; Aaron D. Hernday; Polly M. Fordyce; Liron Noiman; Trevor R. Sorrells; Victor Hanson-Smith; Clariss ..., Proceedings of the National Academy of Sciences current issue, 2013
Sequence-specific DNA-binding proteins are among the most important classes of gene regulatory proteins, controlling changes in transcription that underlie many aspects of biology. In this work, we identify a transcriptional regulator from the human fungal pathogen Candida albicans that binds ...
Accumulation of the FACT complex, as well as histone H3.3, serves as a target marker for somatic hypermutation [Genetics]
07-05-2013 | Masatoshi Aida; Nesreen Hamad; Andre Stanlie; Nasim A. Begum; Tasuku Honjo, Proceedings of the National Academy of Sciences current issue, 2013
Somatic hypermutation (SHM) requires not only the expression of activation-induced cytidine deaminase, but also transcription in the target regions. However, how transcription guides activation-induced cytidine deaminase in targeting SHM to the Ig genes is not fully understood. Here, we found ...
Metallothioneins negatively regulate IL-27-induced type 1 regulatory T-cell differentiation [Immunology]
07-05-2013 | Chuan Wu; Caroline Pot; Lionel Apetoh; Theresa Thalhamer; Bing Zhu; Gopal Murugaiyan; Sheng Xiao; Youjin Lee; Manu R ..., Proceedings of the National Academy of Sciences current issue, 2013
IL-27–induced type 1 regulatory T (Tr1) cells suppress autoimmunity by producing IL-10. Signal transducer and activator of transcription (STAT) 1 and STAT3 have been described as key transcription factors that promote IL-10 secretion from Tr1 cells induced by IL-27. However, the molecular ...
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