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813 Newest Publications in proceedings of the national academy of sciences current issue

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A {Omega}XaV motif in the Rift Valley fever virus NSs protein is essential for degrading p62, forming nuclear filaments and virulence [Biochemistry]

12-May-2015 | Normand Cyr; Cynthia de la Fuente; Lauriane Lecoq; Irene Guendel; Philippe R. Chabot; Kylene Kehn-Hall; James G. Omi ..., Proceedings of the National Academy of Sciences current issue, 2015

Rift Valley fever virus (RVFV) is a single-stranded RNA virus capable of inducing fatal hemorrhagic fever in humans. A key component of RVFV virulence is its ability to form nuclear filaments through interactions between the viral nonstructural protein NSs and the host general transcription ...

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Transcriptome dynamics of developing maize leaves and genomewide prediction of cis elements and their cognate transcription factors [Genetics]

12-May-2015 | Chun-Ping Yu; Sean Chun-Chang Chen; Yao-Ming Chang; Wen-Yu Liu; Hsin-Hung Lin; Jinn-Jy Lin; Hsiang June Chen; Yu-Ju ..., Proceedings of the National Academy of Sciences current issue, 2015

Maize is a major crop and a model plant for studying C4 photosynthesis and leaf development. However, a genomewide regulatory network of leaf development is not yet available. This knowledge is useful for developing C3 crops to perform C4 photosynthesis for enhanced yields. Here, using 22 ...

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Solution structure of the PsIAA4 oligomerization domain reveals interaction modes for transcription factors in early auxin response [Plant Biology]

12-May-2015 | Dhurvas Chandrasekaran Dinesh; Michael Kovermann; Mohanraj Gopalswamy; Antje Hellmuth; Luz Irina A. Calderón Villalo ..., Proceedings of the National Academy of Sciences current issue, 2015

The plant hormone auxin activates primary response genes by facilitating proteolytic removal of AUXIN/INDOLE-3-ACETIC ACID (AUX/IAA)-inducible repressors, which directly bind to transcriptional AUXIN RESPONSE FACTORS (ARF). Most AUX/IAA and ARF proteins share highly conserved C-termini mediating ...

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Direct conversion of human fibroblasts into functional osteoblasts by defined factors [Medical Sciences]

12-May-2015 | Kenta Yamamoto; Tsunao Kishida; Yoshiki Sato; Keisuke Nishioka; Akika Ejima; Hiroyoshi Fujiwara; Toshikazu Kubo; Tos ..., Proceedings of the National Academy of Sciences current issue, 2015

Osteoblasts produce calcified bone matrix and contribute to bone formation and remodeling. In this study, we established a procedure to directly convert human fibroblasts into osteoblasts by transducing some defined factors and culturing in osteogenic medium. Osteoblast-specific transcription ...

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Maternal Wnt/STOP signaling promotes cell division during early Xenopus embryogenesis [Developmental Biology]

05-May-2015 | Ya-Lin Huang; Zeinab Anvarian; Gabriele Döderlein; Sergio P. Acebron; Christof Niehrs, Proceedings of the National Academy of Sciences current issue, 2015

During Xenopus development, Wnt signaling is thought to function first after midblastula transition to regulate axial patterning via β-catenin–mediated transcription. Here, we report that Wnt/glycogen synthase kinase 3 (GSK3) signaling functions posttranscriptionally already in mature oocytes via ...

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Head-to-head antisense transcription and R-loop formation promotes transcriptional activation [Genetics]

05-May-2015 | Raquel Boque-Sastre; Marta Soler; Cristina Oliveira-Mateos; Anna Portela; Catia Moutinho; Sergi Sayols; Alberto Vill ..., Proceedings of the National Academy of Sciences current issue, 2015

The mechanisms used by antisense transcripts to regulate their corresponding sense mRNAs are not fully understood. Herein, we have addressed this issue for the vimentin (VIM) gene, a member of the intermediate filament family involved in cell and tissue integrity that is deregulated in different ...

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Reply to Wilkinson: Minor role of programmed methylation and demethylation in mammalian development [Biological Sciences]

28-Apr-2015 | Timothy H. Bestor; John R. Edwards; Mathieu Boulard, Proceedings of the National Academy of Sciences current issue, 2015

Wilkinson (1) does not dispute any of our (2) main claims: that CpG-dense promoters are unmethylated in all tissues and CpG-poor promoters are variably methylated and undergo transcription factor-induced demethylation after activation; that global genome demethylation in cells and tissues does ...

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Induced transcription and stability of CELF2 mRNA drives widespread alternative splicing during T-cell signaling [Biochemistry]

28-Apr-2015 | Michael J. Mallory; Samuel J. Allon; Jinsong Qiu; Matthew R. Gazzara; Iulia Tapescu; Nicole M. Martinez; Xiang-Dong ..., Proceedings of the National Academy of Sciences current issue, 2015

Studies in several cell types have highlighted dramatic and diverse changes in mRNA processing that occur upon cellular stimulation. However, the mechanisms and pathways that lead to regulated changes in mRNA processing remain poorly understood. Here we demonstrate that expression of the splicing ...

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MeCP2 binds to non-CG methylated DNA as neurons mature, influencing transcription and the timing of onset for Rett syndrome [Neuroscience]

28-Apr-2015 | Lin Chen; Kaifu Chen; Laura A. Lavery; Steven Andrew Baker; Chad A. Shaw; Wei Li; Huda Y. Zoghbi, Proceedings of the National Academy of Sciences current issue, 2015

Epigenetic mechanisms, such as DNA methylation, regulate transcriptional programs to afford the genome flexibility in responding to developmental and environmental cues in health and disease. A prime example involving epigenetic dysfunction is the postnatal neurodevelopmental disorder Rett ...

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Stat1 stimulates cap-independent mRNA translation to inhibit cell proliferation and promote survival in response to antitumor drugs [Biochemistry]

28-Apr-2015 | Shuo Wang; Christos Patsis; Antonis E. Koromilas, Proceedings of the National Academy of Sciences current issue, 2015

The signal transducer and activator of transcription 1 (Stat1) functions as a tumor suppressor via immune regulatory and cell-autonomous pathways. Herein, we report a previously unidentified cell-autonomous Stat1 function, which is its ability to exhibit both antiproliferative and prosurvival ...

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