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778 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

Transcription factor Hes1 modulates osteoarthritis development in cooperation with calcium/calmodulin-dependent protein kinase 2 [Medical Sciences]

10-Mar-2015 | Shurei Sugita; Yoko Hosaka; Keita Okada; Daisuke Mori; Fumiko Yano; Hiroshi Kobayashi; Yuki Taniguchi; Yoshifumi Mor ..., Proceedings of the National Academy of Sciences current issue, 2015

Notch signaling modulates skeletal formation and pathogenesis of osteoarthritis (OA) through induction of catabolic factors. Here we examined roles of Hes1, a transcription factor and important target of Notch signaling, in these processes. SRY-box containing gene 9 (Sox9)-Cre mice were mated ...

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Multicolor CRISPR labeling of chromosomal loci in human cells [Cell Biology]

10-Mar-2015 | Hanhui Ma; Ardalan Naseri; Pablo Reyes-Gutierrez; Scot A. Wolfe; Shaojie Zhang; Thoru Pederson, Proceedings of the National Academy of Sciences current issue, 2015

The intranuclear location of genomic loci and the dynamics of these loci are important parameters for understanding the spatial and temporal regulation of gene expression. Recently it has proven possible to visualize endogenous genomic loci in live cells by the use of transcription activator-like ...

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Transcription factor interaction with COMPASS-like complex regulates histone H3K4 trimethylation for specific gene expression in plants [Plant Biology]

03-Mar-2015 | Ze-Ting Song; Le Sun; Sun-Jie Lu; Yongke Tian; Yong Ding; Jian-Xiang Liu, Proceedings of the National Academy of Sciences current issue, 2015

Accumulation of unfolded or misfolded proteins causes endoplasmic reticulum (ER) stress, which activates a set of ER membrane-associated transcription factors for protein homeostasis regulation. Previous genome-wide chromatin immunoprecipitation analysis shows a strong correlation between histone ...

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Constraints on the evolution of a doublesex target gene arising from doublesex's pleiotropic deployment [Genetics]

24-Feb-2015 | Shengzhan D. Luo; Bruce S. Baker, Proceedings of the National Academy of Sciences current issue, 2015

“Regulatory evolution,” that is, changes in a gene’s expression pattern through changes at its regulatory sequence, rather than changes at the coding sequence of the gene or changes of the upstream transcription factors, has been increasingly recognized as a pervasive evolution mechanism. Many ...

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Structural basis for transcription reactivation by RapA [Biochemistry]

17-Feb-2015 | Bin Liu; Yuhong Zuo; Thomas A. Steitz, Proceedings of the National Academy of Sciences current issue, 2015

RNA polymerase (RNAP) loses activity during transcription as it stalls at various inactive states due to erratic translocation. Reactivation of these stalled RNAPs is essential for efficient RNA synthesis. Here we report a 4.7-Å resolution crystal structure of the Escherichia coli RNAP core ...

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Retraction for Zhang et al., Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex [Retractions]

17-Feb-2015 | Proceedings of the National Academy of Sciences current issue, 2015

CELL BIOLOGY Retraction for “Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex,” by Qinghong Zhang, Su-Yan Wang, Capucine Fleuriel, Dominique Leprince, Jonathan V. Rocheleau, David W. Piston, and Richard H. Goodman, which appeared in issue 3, January 16, 2007, of ...

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Distinct pathways of RNA polymerase regulation by a phage-encoded factor [Biochemistry]

17-Feb-2015 | Daria Esyunina; Evgeny Klimuk; Konstantin Severinov; Andrey Kulbachinskiy, Proceedings of the National Academy of Sciences current issue, 2015

Transcription antitermination is a common strategy of gene expression regulation, but only a few transcription antitermination factors have been studied in detail. Here, we dissect the transcription antitermination mechanism of Xanthomonas oryzae virus Xp10 protein p7, which binds host RNA ...

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Network-based metaanalysis identifies HNF4A and PTBP1 as longitudinally dynamic biomarkers for Parkinson's disease [Neuroscience]

17-Feb-2015 | Jose A. Santiago; Judith A. Potashkin, Proceedings of the National Academy of Sciences current issue, 2015

Environmental and genetic factors are likely to be involved in the pathogenesis of Parkinson’s disease (PD), the second most prevalent neurodegenerative disease among the elderly. Network-based metaanalysis of four independent microarray studies identified the hepatocyte nuclear factor 4 alpha ...

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Bordetella pertussis fim3 gene regulation by BvgA: Phosphorylation controls the formation of inactive vs. active transcription complexes [Biochemistry]

10-Feb-2015 | Alice Boulanger; Kyung Moon; Kimberly B. Decker; Qing Chen; Leslie Knipling; Scott Stibitz; Deborah M. Hinton, Proceedings of the National Academy of Sciences current issue, 2015

Two-component systems [sensor kinase/response regulator (RR)] are major tools used by microorganisms to adapt to environmental conditions. RR phosphorylation is typically required for gene activation, but few studies have addressed how and if phosphorylation affects specific steps during ...

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MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells [Cell Biology]

03-Feb-2015 | Diego Ploper; Vincent F. Taelman; Lidia Robert; Brian S. Perez; Björn Titz; Hsiao-Wang Chen; Thomas G. Graeber; Erik ..., Proceedings of the National Academy of Sciences current issue, 2015

Canonical Wnt signaling plays an important role in development and disease, regulating transcription of target genes and stabilizing many proteins phosphorylated by glycogen synthase kinase 3 (GSK3). We observed that the MiT family of transcription factors, which includes the melanoma oncogene ...

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