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929 Newest Publications in proceedings of the national academy of sciences current issue

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Molecular convergence of clock and photosensory pathways through PIF3-TOC1 interaction and co-occupancy of target promoters [Plant Biology]

26-Apr-2016 | Judit Soy; Pablo Leivar; Nahuel González-Schain; Guiomar Martín; Céline Diaz; Maria Sentandreu; Bassem Al-Sady; Pete ..., Proceedings of the National Academy of Sciences current issue, 2016

A mechanism for integrating light perception and the endogenous circadian clock is central to a plant’s capacity to coordinate its growth and development with the prevailing daily light/dark cycles. Under short-day (SD) photocycles, hypocotyl elongation is maximal at dawn, being promoted by the ...

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Dimethyl fumarate treatment induces adaptive and innate immune modulation independent of Nrf2 [Immunology and Inflammation]

26-Apr-2016 | Ulf Schulze-Topphoff; Michel Varrin-Doyer; Kara Pekarek; Collin M. Spencer; Aparna Shetty; Sharon A. Sagan; Bruce A. ..., Proceedings of the National Academy of Sciences current issue, 2016

Dimethyl fumarate (DMF) (BG-12, Tecfidera) is a fumaric acid ester (FAE) that was advanced as a multiple sclerosis (MS) therapy largely for potential neuroprotection as it was recognized that FAEs are capable of activating the antioxidative transcription factor nuclear factor (erythroid-derived ...

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Interallelic interaction and gene regulation in budding yeast [Genetics]

19-Apr-2016 | Daoyong Zhang; Lu Bai, Proceedings of the National Academy of Sciences current issue, 2016

In Drosophila, homologous chromosome pairing leads to “transvection,” in which the enhancer of a gene can regulate the allelic transcription in trans. Interallelic interactions were also observed in vegetative diploid budding yeast, but their functional significance is unknown. Here, we show that ...

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Asymmetric arginine dimethylation of RelA provides a repressive mark to modulate TNF{alpha}/NF-{kappa}B response [Biochemistry]

19-Apr-2016 | Anja Reintjes; Julian E. Fuchs; Leopold Kremser; Herbert H. Lindner; Klaus R. Liedl; Lukas A. Huber; Taras Valovka, Proceedings of the National Academy of Sciences current issue, 2016

Nuclear factor kappa B (NF-κB) is an inducible transcription factor that plays critical roles in immune and stress responses and is often implicated in pathologies, including chronic inflammation and cancer. Although much has been learned about NF-κB–activating pathways, the specific repression ...

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Functional architecture of the Reb1-Ter complex of Schizosaccharomyces pombe [Biochemistry]

19-Apr-2016 | Rahul Jaiswal; Malay Choudhury; Shamsu Zaman; Samarendra Singh; Vishaka Santosh; Deepak Bastia; Carlos R. Escalante, Proceedings of the National Academy of Sciences current issue, 2016

Reb1 of Schizosaccharomyces pombe represents a family of multifunctional proteins that bind to specific terminator sites (Ter) and cause polar termination of transcription catalyzed by RNA polymerase I (pol I) and arrest of replication forks approaching the Ter sites from the opposite direction. ...

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Structures of E. coli {sigma}S-transcription initiation complexes provide new insights into polymerase mechanism [Biochemistry]

12-Apr-2016 | Bin Liu; Yuhong Zuo; Thomas A. Steitz, Proceedings of the National Academy of Sciences current issue, 2016

In bacteria, multiple σ factors compete to associate with the RNA polymerase (RNAP) core enzyme to form a holoenzyme that is required for promoter recognition. During transcription initiation RNAP remains associated with the upstream promoter DNA via sequence-specific interactions between the σ ...

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Rethinking progesterone regulation of female reproductive cyclicity [Physiology]

12-Apr-2016 | Kaiyu Kubota; Wei Cui; Pramod Dhakal; Michael W. Wolfe; M. A. Karim Rumi; Jay L. Vivian; Katherine F. Roby; Michael ..., Proceedings of the National Academy of Sciences current issue, 2016

The progesterone receptor (PGR) is a ligand-activated transcription factor with key roles in the regulation of female fertility. Much has been learned of the actions of PGR signaling through the use of pharmacologic inhibitors and genetic manipulation, using mouse mutagenesis. Characterization of ...

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GOLDEN 2-LIKE transcription factors for chloroplast development affect ozone tolerance through the regulation of stomatal movement [Plant Biology]

12-Apr-2016 | Yukari Nagatoshi; Nobutaka Mitsuda; Maki Hayashi; Shin-ichiro Inoue; Eiji Okuma; Akihiro Kubo; Yoshiyuki Murata; Mit ..., Proceedings of the National Academy of Sciences current issue, 2016

Stomatal movements regulate gas exchange, thus directly affecting the efficiency of photosynthesis and the sensitivity of plants to air pollutants such as ozone. The GARP family transcription factors GOLDEN 2-LIKE1 (GLK1) and GLK2 have known functions in chloroplast development. Here, we show ...

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Regulation of normal B-cell differentiation and malignant B-cell survival by OCT2 [Medical Sciences]

05-Apr-2016 | Daniel J. Hodson; Arthur L. Shaffer; Wenming Xiao; George W. Wright; Roland Schmitz; James D. Phelan; Yandan Yang; D ..., Proceedings of the National Academy of Sciences current issue, 2016

The requirement for the B-cell transcription factor OCT2 (octamer-binding protein 2, encoded by Pou2f2) in germinal center B cells has proved controversial. Here, we report that germinal center B cells are formed normally after depletion of OCT2 in a conditional knockout mouse, but their ...

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Putative oncogene Brachyury (T) is essential to specify cell fate but dispensable for notochord progenitor proliferation and EMT [Developmental Biology]

05-Apr-2016 | Jianjian Zhu; Kin Ming Kwan; Susan Mackem, Proceedings of the National Academy of Sciences current issue, 2016

The transcription factor Brachyury (T) gene is expressed throughout primary mesoderm (primitive streak and notochord) during early embryonic development and has been strongly implicated in the genesis of chordoma, a sarcoma of notochord cell origin. Additionally, T expression has been found in ...

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