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895 Newest Publications in proceedings of the national academy of sciences current issue

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Bacterial RNA polymerase can retain {sigma}70 throughout transcription [Biochemistry]

19-Jan-2016 | Timothy T. Harden; Christopher D. Wells; Larry J. Friedman; Robert Landick; Ann Hochschild; Jane Kondev; Jeff Gelles, Proceedings of the National Academy of Sciences current issue, 2016

Production of a messenger RNA proceeds through sequential stages of transcription initiation and transcript elongation and termination. During each of these stages, RNA polymerase (RNAP) function is regulated by RNAP-associated protein factors. In bacteria, RNAP-associated σ factors are strictly ...

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Autoregulatory loop of nuclear corepressor 1 expression controls invasion, tumor growth, and metastasis [Medical Sciences]

19-Jan-2016 | Olaia A. Martínez-Iglesias; Elvira Alonso-Merino; Sara Gómez-Rey; Juan Pedro Velasco-Martín; Rosa Martín Orozco; Enr ..., Proceedings of the National Academy of Sciences current issue, 2016

Nuclear corepressor 1 (NCoR) associates with nuclear receptors and other transcription factors leading to transcriptional repression. We show here that NCoR depletion enhances cancer cell invasion and increases tumor growth and metastatic potential in nude mice. These changes are related to ...

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Correction for Yan et al., Imbalanced signal transduction in regulatory T cells expressing the transcription factor FoxP3 [Corrections]

12-Jan-2016 | Proceedings of the National Academy of Sciences current issue, 2016

IMMUNOLOGY AND INFLAMMATION Correction for “Imbalanced signal transduction in regulatory T cells expressing the transcription factor FoxP3,” by Dapeng Yan, Julia Farache, Diane Mathis, and Christophe Benoist, which appeared in issue 48, December 1, 2015, of Proc Natl Acad Sci USA ...

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Understanding TRPV1 activation by ligands: Insights from the binding modes of capsaicin and resiniferatoxin [Biophysics and Computational Biology]

12-Jan-2016 | Khaled Elokely; Phanindra Velisetty; Lucie Delemotte; Eugene Palovcak; Michael L. Klein; Tibor Rohacs; Vincenzo Carn ..., Proceedings of the National Academy of Sciences current issue, 2016

The transient receptor potential cation channel subfamily V member 1 (TRPV1) or vanilloid receptor 1 is a nonselective cation channel that is involved in the detection and transduction of nociceptive stimuli. Inflammation and nerve damage result in the up-regulation of TRPV1 transcription, and, ...

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Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space [Biochemistry]

12-Jan-2016 | William H. Hudson; Bradley R. Kossmann; Ian Mitchelle S. de Vera; Shih-Wei Chuo; Emily R. Weikum; Geeta N. Eick; Jos ..., Proceedings of the National Academy of Sciences current issue, 2016

Many genomes contain families of paralogs—proteins with divergent function that evolved from a common ancestral gene after a duplication event. To understand how paralogous transcription factors evolve divergent DNA specificities, we examined how the glucocorticoid receptor and its paralogs ...

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Regulation of neural gene transcription by optogenetic inhibition of the RE1-silencing transcription factor [Neuroscience]

05-Jan-2016 | Francesco Paonessa; Stefania Criscuolo; Silvio Sacchetti; Davide Amoroso; Helena Scarongella; Federico Pecoraro Biso ..., Proceedings of the National Academy of Sciences current issue, 2016

Optogenetics provides new ways to activate gene transcription; however, no attempts have been made as yet to modulate mammalian transcription factors. We report the light-mediated regulation of the repressor element 1 (RE1)-silencing transcription factor (REST), a master regulator of neural ...

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Specific induction of endogenous viral restriction factors using CRISPR/Cas-derived transcriptional activators [Microbiology]

29-Dec-2015 | Hal P. Bogerd; Anand V. R. Kornepati; Joy B. Marshall; Edward M. Kennedy; Bryan R. Cullen, Proceedings of the National Academy of Sciences current issue, 2015

Whereas several mammalian proteins can restrict the replication of HIV-1 and other viruses, these are often not expressed in relevant target cells. A potential method to inhibit viral replication might therefore be to use synthetic transcription factors to induce restriction factor expression. In ...

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Tmem178 acts in a novel negative feedback loop targeting NFATc1 to regulate bone mass [Cell Biology]

22-Dec-2015 | Corinne E. Decker; Zhengfeng Yang; Ryan Rimer; Kyung-Hyun Park-Min; Claudia Macaubas; Elizabeth D. Mellins; Deborah ..., Proceedings of the National Academy of Sciences current issue, 2015

Phospholipase C gamma-2 (PLCγ2)-dependent calcium (Ca2+) oscillations are indispensable for nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1) activation and downstream gene transcription driving osteoclastogenesis during skeletal remodeling and pathological bone loss. Here we describe, ...

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Conserved factor Dhp1/Rat1/Xrn2 triggers premature transcription termination and nucleates heterochromatin to promote gene silencing [Genetics]

22-Dec-2015 | Venkata R. Chalamcharla; H. Diego Folco; Jothy Dhakshnamoorthy; Shiv I. S. Grewal, Proceedings of the National Academy of Sciences current issue, 2015

Cotranscriptional RNA processing and surveillance factors mediate heterochromatin formation in diverse eukaryotes. In fission yeast, RNAi machinery and RNA elimination factors including the Mtl1–Red1 core and the exosome are involved in facultative heterochromatin assembly; however, the exact ...

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Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21 [Cell Biology]

15-Dec-2015 | Cuiyan Zhang; Xiaotong Li; Guillaume Adelmant; Jessica Dobbins; Christoph Geisen; Matthew G. Oser; Kai W. Wucherpfen ..., Proceedings of the National Academy of Sciences current issue, 2015

EP300-interacting inhibitor of differentiation 1 (EID1) belongs to a protein family implicated in the control of transcription, differentiation, DNA repair, and chromosomal maintenance. EID1 has a very short half-life, especially in G0 cells. We discovered that EID1 contains a peptidic, modular ...

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