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757 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

Structural basis of HIV-1 capsid recognition by PF74 and CPSF6 [Biophysics and Computational Biology]

30-Dec-2014 | Akash Bhattacharya; Steven L. Alam; Thomas Fricke; Kaneil Zadrozny; Jaroslaw Sedzicki; Alexander B. Taylor; Borries ..., Proceedings of the National Academy of Sciences current issue, 2014

Upon infection of susceptible cells by HIV-1, the conical capsid formed by ∼250 hexamers and 12 pentamers of the CA protein is delivered to the cytoplasm. The capsid shields the RNA genome and proteins required for reverse transcription. In addition, the surface of the capsid mediates numerous ...

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Hedgehog-induced phosphorylation by CK1 sustains the activity of Ci/Gli activator [Developmental Biology]

30-Dec-2014 | Qing Shi; Shuang Li; Shuangxi Li; Alice Jiang; Yongbin Chen; Jin Jiang, Proceedings of the National Academy of Sciences current issue, 2014

Hedgehog (Hh) signaling governs many developmental processes by regulating the balance between the repressor (CiR/GliR) and activator (CiA/GliA) forms of Cubitus interruptus (Ci)/glioma-associated oncogene homolog (Gli) transcription factors. Although much is known about how CiR/GliR is ...

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Treacher Collins syndrome TCOF1 protein cooperates with NBS1 in the DNA damage response [Cell Biology]

30-Dec-2014 | Alberto Ciccia; Jen-Wei Huang; Lior Izhar; Mathew E. Sowa; J. Wade Harper; Stephen J. Elledge, Proceedings of the National Academy of Sciences current issue, 2014

The signal transduction pathway of the DNA damage response (DDR) is activated to maintain genomic integrity following DNA damage. The DDR promotes genomic integrity by regulating a large network of cellular activities that range from DNA replication and repair to transcription, RNA splicing, and ...

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Maize SBP-box transcription factors unbranched2 and unbranched3 affect yield traits by regulating the rate of lateral primordia initiation [Plant Biology]

30-Dec-2014 | George S. Chuck; Patrick J. Brown; Robert Meeley; Sarah Hake, Proceedings of the National Academy of Sciences current issue, 2014

The separation of male and female flowers in maize provides the potential for independent regulation of traits that affect crop productivity. For example, tassel branch number controls pollen abundance and length of shedding time, whereas ear row number directly affects kernel yield. Mutations in ...

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ROR{gamma}t-specific transcriptional interactomic inhibition suppresses autoimmunity associated with TH17 cells [Immunology and Inflammation]

30-Dec-2014 | Tae-Yoon Park; Sung-Dong Park; Jen-Young Cho; Jae-Seung Moon; Na-Yeon Kim; Kyungsoo Park; Rho Hyun Seong; Sang-Won L ..., Proceedings of the National Academy of Sciences current issue, 2014

The nuclear hormone receptor retinoic acid-related orphan receptor gamma t (RORγt) is a transcription factor (TF) specific to TH17 cells that produce interleukin (IL)-17 and have been implicated in a wide range of autoimmunity. Here, we developed a novel therapeutic strategy to modulate the ...

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Phytochrome controls alternative splicing to mediate light responses in Arabidopsis [Plant Biology]

30-Dec-2014 | Hiromasa Shikata; Kousuke Hanada; Tomokazu Ushijima; Moeko Nakashima; Yutaka Suzuki; Tomonao Matsushita, Proceedings of the National Academy of Sciences current issue, 2014

Plants monitor the ambient light conditions using several informational photoreceptors, including red/far-red light absorbing phytochrome. Phytochrome is widely believed to regulate the transcription of light-responsive genes by modulating the activity of several transcription factors. Here we ...

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IKK{beta} is an IRF5 kinase that instigates inflammation [Biochemistry]

09-Dec-2014 | Junyao Ren; Xiang Chen; Zhijian J. Chen, Proceedings of the National Academy of Sciences current issue, 2014

The transcription factor interferon regulatory factor 5 (IRF5) is essential for the induction of inflammatory cytokines, but the mechanism by which IRF5 is activated is not well understood. Here we present evidence that the kinase IKKβ phosphorylates and activates IRF5 in response to stimulation ...

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Innate sense of purpose for IKK{beta} [Biochemistry]

09-Dec-2014 | Matthew S. Hayden; Sankar Ghosh, Proceedings of the National Academy of Sciences current issue, 2014

The innate immune response is initiated upon recognition of pathogen-associated molecular patterns (PAMPs) by germ-line encoded pattern-recognition receptors (PRRs). PRRs including transmembrane receptors, typified by the Toll-like receptors (TLR) and cytoplasmic receptors, including the ...

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Increased subtlety of transcription factor binding increases complexity of genome regulation [Biochemistry]

09-Dec-2014 | Peter H. von Hippel, Proceedings of the National Academy of Sciences current issue, 2014

In PNAS, Afek et al. (1) show that the specific (or “consensus”) base-pair sequences of a regulatory DNA target are not solely responsible for controlling the binding affinities of several eukaryotic transcription factors (TFs) for their DNA target sites. Rather, so-called “nonconsensus” ...

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Analysis of clock-regulated genes in Neurospora reveals widespread posttranscriptional control of metabolic potential [Cell Biology]

02-Dec-2014 | Jennifer M. Hurley; Arko Dasgupta; Jillian M. Emerson; Xiaoying Zhou; Carol S. Ringelberg; Nicole Knabe; Anna M. Lip ..., Proceedings of the National Academy of Sciences current issue, 2014

Neurospora crassa has been for decades a principal model for filamentous fungal genetics and physiology as well as for understanding the mechanism of circadian clocks. Eukaryotic fungal and animal clocks comprise transcription-translation–based feedback loops that control rhythmic transcription ...

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