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741 Newest Publications in proceedings of the national academy of sciences current issue

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A circadian gene expression atlas in mammals: Implications for biology and medicine [Systems Biology]

11-11-2014 | Ray Zhang; Nicholas F. Lahens; Heather I. Ballance; Michael E. Hughes; John B. Hogenesch, Proceedings of the National Academy of Sciences current issue, 2014

To characterize the role of the circadian clock in mouse physiology and behavior, we used RNA-seq and DNA arrays to quantify the transcriptomes of 12 mouse organs over time. We found 43% of all protein coding genes showed circadian rhythms in transcription somewhere in the body, largely in an ...

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Sensing nerve injury at the axonal ER: Activated Luman/CREB3 serves as a novel axonally synthesized retrograde regeneration signal [Neuroscience]

11-11-2014 | Zhengxin Ying; Vikram Misra; Valerie M. K. Verge, Proceedings of the National Academy of Sciences current issue, 2014

Luman/cAMP response element binding protein 3 is an endoplasmic reticulum (ER) transmembrane basic leucine zipper transcription factor whose mRNA and protein localize to adult sensory axons, the latter with axonal ER components along the axon length. Here we show that axon-derived Luman plays an ...

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p100/I{kappa}B{delta} sequesters and inhibits NF-{kappa}B through kappaBsome formation [Biochemistry]

11-11-2014 | Zhihua Tao; Amanda Fusco; De-Bin Huang; Kushol Gupta; Daniel Young Kim; Carl F. Ware; Gregory D. Van Duyne; Gourisan ..., Proceedings of the National Academy of Sciences current issue, 2014

Degradation of I kappaB (κB) inhibitors is critical to activation of dimeric transcription factors of the NF-κB family. There are two types of IκB inhibitors: the prototypical IκBs (IκBα, IκBβ, and IκBε), which form low-molecular-weight (MW) IκB:NF-κB complexes that are highly stable, and the ...

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DNA supercoiling: A regulatory signal for the {lambda} repressor [Biophysics and Computational Biology]

28-10-2014 | Yue Ding; Carlo Manzo; Geraldine Fulcrand; Fenfei Leng; David Dunlap; Laura Finzi, Proceedings of the National Academy of Sciences current issue, 2014

Topoisomerases, polymerases, and the chirality introduced by the binding of histones or nucleoid-associated proteins affect DNA supercoiling in vivo. However, supercoiling is not just a by-product of DNA metabolism. Supercoiling is an indicator of cell health, it modifies the accessibility of ...

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Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in classical Hodgkin lymphoma [Medical Sciences]

21-10-2014 | Stephan Kreher; M. Amine Bouhlel; Pierre Cauchy; Björn Lamprecht; Shuang Li; Michael Grau; Franziska Hummel; Karl Kö ..., Proceedings of the National Academy of Sciences current issue, 2014

Deregulated transcription factor (TF) activities are commonly observed in hematopoietic malignancies. Understanding tumorigenesis therefore requires determining the function and hierarchical role of individual TFs. To identify TFs central to lymphomagenesis, we identified lymphoma type-specific ...

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KAISO, a critical regulator of p53-mediated transcription of CDKN1A and apoptotic genes [Biochemistry]

21-10-2014 | Dong-In Koh; Dohyun Han; Hoon Ryu; Won-Il Choi; Bu-Nam Jeon; Min-Kyeong Kim; Youngsoo Kim; Jin Young Kim; Lee Parry; ..., Proceedings of the National Academy of Sciences current issue, 2014

An unresolved issue in genotoxic stress response is identification of induced regulatory proteins and how these activate tumor suppressor p53 to determine appropriate cell responses. Transcription factor KAISO was previously described to repress transcription following binding to methylated DNA. ...

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Structural studies on the authentic mumps virus nucleocapsid showing uncoiling by the phosphoprotein [Microbiology]

21-10-2014 | Robert Cox; Adrian Pickar; Shihong Qiu; Jun Tsao; Cynthia Rodenburg; Terje Dokland; Andrew Elson; Biao He; Ming Luo, Proceedings of the National Academy of Sciences current issue, 2014

Mumps virus (MuV) is a highly contagious pathogen, and despite extensive vaccination campaigns, outbreaks continue to occur worldwide. The virus has a negative-sense, single-stranded RNA genome that is encapsidated by the nucleocapsid protein (N) to form the nucleocapsid (NC). NC serves as the ...

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Nitrate foraging by Arabidopsis roots is mediated by the transcription factor TCP20 through the systemic signaling pathway [Plant Biology]

21-10-2014 | Peizhu Guan; Rongchen Wang; Philippe Nacry; Ghislain Breton; Steve A. Kay; Jose L. Pruneda-Paz; Ariea Davani; Nigel ..., Proceedings of the National Academy of Sciences current issue, 2014

To compete for nutrients in diverse soil microenvironments, plants proliferate lateral roots preferentially in nutrient-rich zones. For nitrate, root foraging involves local and systemic signaling; however, little is known about the genes that function in the systemic signaling pathway. By using ...

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SPX1 is a phosphate-dependent inhibitor of PHOSPHATE STARVATION RESPONSE 1 in Arabidopsis [Plant Biology]

14-10-2014 | María Isabel Puga; Isabel Mateos; Rajulu Charukesi; Zhiye Wang; José M. Franco-Zorrilla; Laura de Lorenzo; María L. ..., Proceedings of the National Academy of Sciences current issue, 2014

To cope with growth in low-phosphate (Pi) soils, plants have evolved adaptive responses that involve both developmental and metabolic changes. PHOSPHATE STARVATION RESPONSE 1 (PHR1) and related transcription factors play a central role in the control of Pi starvation responses (PSRs). How Pi ...

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Structural basis of cellular dNTP regulation by SAMHD1 [Biochemistry]

14-10-2014 | Xiaoyun Ji; Chenxiang Tang; Qi Zhao; Wei Wang; Yong Xiong, Proceedings of the National Academy of Sciences current issue, 2014

The sterile alpha motif and HD domain-containing protein 1 (SAMHD1), a dNTPase, prevents the infection of nondividing cells by retroviruses, including HIV, by depleting the cellular dNTP pool available for viral reverse transcription. SAMHD1 is a major regulator of cellular dNTP levels in ...

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