My watch list
my.chemeurope.com  
Login  

591 Newest Publications in proceedings of the national academy of sciences current issue

rss
matching the following criteria

EGFR inhibition evokes innate drug resistance in lung cancer cells by preventing Akt activity and thus inactivating Ets-1 function [Cell Biology]

21-Jul-2015 | Janyaporn Phuchareon; Frank McCormick; David W. Eisele; Osamu Tetsu, Proceedings of the National Academy of Sciences current issue, 2015

Nonsmall cell lung cancer (NSCLC) is the leading cause of cancer death worldwide. About 14% of NSCLCs harbor mutations in epidermal growth factor receptor (EGFR). Despite remarkable progress in treatment with tyrosine kinase inhibitors (TKIs), only 5% of patients achieve tumor reduction >90%. The ...

more

Jagged mediates differences in normal and tumor angiogenesis by affecting tip-stalk fate decision [Biophysics and Computational Biology]

21-Jul-2015 | Marcelo Boareto; Mohit Kumar Jolly; Eshel Ben-Jacob; José N. Onuchic, Proceedings of the National Academy of Sciences current issue, 2015

Angiogenesis is critical during development, wound repair, and cancer progression. During angiogenesis, some endothelial cells adopt a tip phenotype to lead the formation of new branching vessels; the trailing stalk cells proliferate to develop the vessel. Notch and VEGF signaling mediate the ...

more

F-box protein FBXO31 directs degradation of MDM2 to facilitate p53-mediated growth arrest following genotoxic stress [Cell Biology]

14-Jul-2015 | Sunil K. Malonia; Parul Dutta; Manas Kumar Santra; Michael R. Green, Proceedings of the National Academy of Sciences current issue, 2015

The tumor suppressor p53 plays a critical role in maintaining genomic stability. In response to genotoxic stress, p53 levels increase and induce cell-cycle arrest, senescence, or apoptosis, thereby preventing replication of damaged DNA. In unstressed cells, p53 is maintained at a low level. The ...

more

Reply to Ciccolini et al.: Using mathematical modeling to predict response to antiangiogenic therapy in cancer patients [Biological Sciences]

07-Jul-2015 | Dan G. Duda; Rebecca S. Heist; Dushyant V. Sahani; Triantafyllos Stylianopoulos; Jeffrey A. Engelman; Rakesh K. Jain, Proceedings of the National Academy of Sciences current issue, 2015

We thank Ciccolini et al. (1) for their interest in our report (2) on a clinical study, published recently in PNAS. In that paper, we report that improved tumor vascular function after anti-VEGF therapy with carboplatin and nab-paclitaxel associates with survival in non-small cell lung cancer ...

more

Discovering the first tyrosine kinase [Biochemistry]

30-Jun-2015 | Tony Hunter, Proceedings of the National Academy of Sciences current issue, 2015

In the middle of the 20th century, animal tumor viruses were heralded as possible models for understanding human cancer. By the mid-1970s, the molecular basis by which tumor viruses transform cells into a malignant state was beginning to emerge as the first viral genomic sequences were reported ...

more

TLR4 has a TP53-dependent dual role in regulating breast cancer cell growth [Cell Biology]

23-Jun-2015 | Svasti Haricharan; Powel Brown, Proceedings of the National Academy of Sciences current issue, 2015

Breast cancer is a leading cause of cancer-related death, and it is important to understand pathways that drive the disease to devise effective therapeutic strategies. Our results show that Toll-like receptor 4 (TLR4) drives breast cancer cell growth differentially based on the presence of TP53, ...

more

Inference of transcriptional regulation in cancers [Biophysics and Computational Biology]

23-Jun-2015 | Peng Jiang; Matthew L. Freedman; Jun S. Liu; Xiaole Shirley Liu, Proceedings of the National Academy of Sciences current issue, 2015

Despite the rapid accumulation of tumor-profiling data and transcription factor (TF) ChIP-seq profiles, efforts integrating TF binding with the tumor-profiling data to understand how TFs regulate tumor gene expression are still limited. To systematically search for cancer-associated TFs, we ...

more

Systematic transcriptome analysis reveals tumor-specific isoforms for ovarian cancer diagnosis and therapy [Medical Sciences]

09-Jun-2015 | Christian L. Barrett; Christopher DeBoever; Kristen Jepsen; Cheryl C. Saenz; Dennis A. Carson; Kelly A. Frazer, Proceedings of the National Academy of Sciences current issue, 2015

Tumor-specific molecules are needed across diverse areas of oncology for use in early detection, diagnosis, prognosis and therapy. Large and growing public databases of transcriptome sequencing data (RNA-seq) derived from tumors and normal tissues hold the potential of yielding tumor-specific ...

more

In vitro model for lytic replication, latency, and transformation of an oncogenic alphaherpesvirus [Microbiology]

09-Jun-2015 | Julia Schermuly; Annachiara Greco; Sonja Härtle; Nikolaus Osterrieder; Benedikt B. Kaufer; Bernd Kaspers, Proceedings of the National Academy of Sciences current issue, 2015

Marek’s disease virus (MDV) is an alphaherpesvirus that causes deadly T-cell lymphomas in chickens and serves as a natural small animal model for virus-induced tumor formation. In vivo, MDV lytically replicates in B cells that transfer the virus to T cells in which the virus establishes latency. ...

more

VEGF-B promotes cancer metastasis through a VEGF-A-independent mechanism and serves as a marker of poor prognosis for cancer patients [Medical Sciences]

02-Jun-2015 | Xiaojuan Yang; Yin Zhang; Kayoko Hosaka; Patrik Andersson; Jian Wang; Fredrik Tholander; Ziquan Cao; Hiromasa Morika ..., Proceedings of the National Academy of Sciences current issue, 2015

The biological functions of VEGF-B in cancer progression remain poorly understood. Here, we report that VEGF-B promotes cancer metastasis through the remodeling of tumor microvasculature. Knockdown of VEGF-B in tumors resulted in increased perivascular cell coverage and impaired pulmonary ...

more

Page 1 From 60
Subscribe to e-mail updates relating to your search

You will receive via e-mail the latest search results matching your search criteria. This service is free of charge and can be cancelled at any time.

Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE