My watch list
my.chemeurope.com  
Login  

580 Newest Publications in proceedings of the national academy of sciences current issue

rss
matching the following criteria

Multisite interaction with Sufu regulates Ci/Gli activity through distinct mechanisms in Hh signal transduction [Developmental Biology]

19-May-2015 | Yuhong Han; Qing Shi; Jin Jiang, Proceedings of the National Academy of Sciences current issue, 2015

The tumor suppressor protein Suppressor of fused (Sufu) plays a conserved role in the Hedgehog (Hh) signaling pathway by inhibiting Cubitus interruptus (Ci)/Glioma-associated oncogene homolog (Gli) transcription factors, but the molecular mechanism by which Sufu inhibits Ci/Gli activity remains ...

more

IL-33 activates tumor stroma to promote intestinal polyposis [Immunology and Inflammation]

12-May-2015 | Rebecca L. Maywald; Stephanie K. Doerner; Luca Pastorelli; Carlo De Salvo; Susan M. Benton; Emily P. Dawson; Denise ..., Proceedings of the National Academy of Sciences current issue, 2015

Tumor epithelial cells develop within a microenvironment consisting of extracellular matrix, growth factors, and cytokines produced by nonepithelial stromal cells. In response to paracrine signals from tumor epithelia, stromal cells modify the microenvironment to promote tumor growth and ...

more

QnAs with Patrick Moore [QnAs]

12-May-2015 | Jennifer Viegas, Proceedings of the National Academy of Sciences current issue, 2015

Since its inception just over a century ago, the field of tumor virology has provided insights into the causes for many cancers. Patrick Moore, director of the Cancer Virology Program at the University of Pittsburgh, is a leading contributor to the field, having codiscovered two of the seven ...

more

Noninvasive imaging of immune responses [Immunology and Inflammation]

12-May-2015 | Mohammad Rashidian; Edmund J. Keliher; Angelina M. Bilate; Joao N. Duarte; Gregory R. Wojtkiewicz; Johanne Tracey Ja ..., Proceedings of the National Academy of Sciences current issue, 2015

At their margins, tumors often contain neutrophils, dendritic cells, and activated macrophages, which express class II MHC and CD11b products. The interplay between stromal cells, tumor cells, and migratory cells such as lymphocytes creates opportunities for noninvasive imaging of immune ...

more

NK cells require IL-28R for optimal in vivo activity [Immunology and Inflammation]

05-May-2015 | Fernando Souza-Fonseca-Guimaraes; Arabella Young; Deepak Mittal; Ludovic Martinet; Claudia Bruedigam; Kazuyoshi Take ..., Proceedings of the National Academy of Sciences current issue, 2015

Natural killer (NK) cells are naturally circulating innate lymphoid cells that protect against tumor initiation and metastasis and contribute to immunopathology during inflammation. The signals that prime NK cells are not completely understood, and, although the importance of IFN type I is well ...

more

Stat1 stimulates cap-independent mRNA translation to inhibit cell proliferation and promote survival in response to antitumor drugs [Biochemistry]

28-Apr-2015 | Shuo Wang; Christos Patsis; Antonis E. Koromilas, Proceedings of the National Academy of Sciences current issue, 2015

The signal transducer and activator of transcription 1 (Stat1) functions as a tumor suppressor via immune regulatory and cell-autonomous pathways. Herein, we report a previously unidentified cell-autonomous Stat1 function, which is its ability to exhibit both antiproliferative and prosurvival ...

more

Acoustic separation of circulating tumor cells [Cell Biology]

21-Apr-2015 | Peng Li; Zhangming Mao; Zhangli Peng; Lanlan Zhou; Yuchao Chen; Po-Hsun Huang; Cristina I. Truica; Joseph J. Drabick ..., Proceedings of the National Academy of Sciences current issue, 2015

Circulating tumor cells (CTCs) are important targets for cancer biology studies. To further elucidate the role of CTCs in cancer metastasis and prognosis, effective methods for isolating extremely rare tumor cells from peripheral blood must be developed. Acoustic-based methods, which are known to ...

more

CD14-expressing cancer cells establish the inflammatory and proliferative tumor microenvironment in bladder cancer [Immunology and Inflammation]

14-Apr-2015 | Ming T. Cheah; James Y. Chen; Debashis Sahoo; Humberto Contreras-Trujillo; Anne K. Volkmer; Ferenc A. Scheeren; Jens ..., Proceedings of the National Academy of Sciences current issue, 2015

Nonresolving chronic inflammation at the neoplastic site is consistently associated with promoting tumor progression and poor patient outcomes. However, many aspects behind the mechanisms that establish this tumor-promoting inflammatory microenvironment remain undefined. Using bladder cancer (BC) ...

more

Estrogen receptor {alpha} inhibitor activates the unfolded protein response, blocks protein synthesis, and induces tumor regression [Medical Sciences]

14-Apr-2015 | Neal D. Andruska; Xiaobin Zheng; Xujuan Yang; Chengjian Mao; Mathew M. Cherian; Lily Mahapatra; William G. Helferich ..., Proceedings of the National Academy of Sciences current issue, 2015

Recurrent estrogen receptor α (ERα)-positive breast and ovarian cancers are often therapy resistant. Using screening and functional validation, we identified BHPI, a potent noncompetitive small molecule ERα biomodulator that selectively blocks proliferation of drug-resistant ERα-positive breast ...

more

TCR contact residue hydrophobicity is a hallmark of immunogenic CD8+ T cell epitopes [Medical Sciences]

07-Apr-2015 | Diego Chowell; Sri Krishna; Pablo D. Becker; Clément Cocita; Jack Shu; Xuefang Tan; Philip D. Greenberg; Linda S. Kl ..., Proceedings of the National Academy of Sciences current issue, 2015

Despite the availability of major histocompatibility complex (MHC)-binding peptide prediction algorithms, the development of T-cell vaccines against pathogen and tumor antigens remains challenged by inefficient identification of immunogenic epitopes. CD8+ T cells must distinguish immunogenic ...

more

Page 1 From 58
Subscribe to e-mail updates relating to your search

You will receive via e-mail the latest search results matching your search criteria. This service is free of charge and can be cancelled at any time.

Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE