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472 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

Cellular capsules as a tool for multicellular spheroid production and for investigating the mechanics of tumor progression in vitro [Cell Biology]

10-09-2013 | Kévin Alessandri; Bibhu Ranjan Sarangi; Vasily Valérïévitch Gurchenkov; Bidisha Sinha; Tobias Reinhold Kießling; Luc ..., Proceedings of the National Academy of Sciences current issue, 2013

Deciphering the multifactorial determinants of tumor progression requires standardized high-throughput preparation of 3D in vitro cellular assays. We present a simple microfluidic method based on the encapsulation and growth of cells inside permeable, elastic, hollow microspheres. We show that ...

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Insulin growth factor signaling is regulated by microRNA-486, an underexpressed microRNA in lung cancer [Medical Sciences]

10-09-2013 | Yong Peng; Yuntao Dai; Charles Hitchcock; Xiaojuan Yang; Edmund S. Kassis; Lunxu Liu; Zhenghua Luo; Hui-Lung Sun; Ri ..., Proceedings of the National Academy of Sciences current issue, 2013

MicroRNAs (miRNAs) are small 19- to 24-nt noncoding RNAs that have the capacity to regulate fundamental biological processes essential for cancer initiation and progression. In cancer, miRNAs may function as oncogenes or tumor suppressors. Here, we conducted global profiling for miRNAs in a ...

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A nanoparticle formulation that selectively transfects metastatic tumors in mice [Medical Sciences]

03-09-2013 | Jian Yang; William Hendricks; Guosheng Liu; J. Michael McCaffery; Kenneth W. Kinzler; David L. Huso; Bert Vogelstein ..., Proceedings of the National Academy of Sciences current issue, 2013

Nanoparticle gene therapy holds great promise for the treatment of malignant disease in light of the large number of potent, tumor-specific therapeutic payloads potentially available for delivery. To be effective, gene therapy vehicles must be able to deliver their therapeutic payloads to ...

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Blockade of A2A receptors potently suppresses the metastasis of CD73+ tumors [Immunology]

03-09-2013 | Paul A. Beavis; Upulie Divisekera; Christophe Paget; Melvyn T. Chow; Liza B. John; Christel Devaud; Karen Dwyer; Joh ..., Proceedings of the National Academy of Sciences current issue, 2013

CD73 inhibits antitumor immunity through the activation of adenosine receptors expressed on multiple immune subsets. CD73 also enhances tumor metastasis, although the nature of the immune subsets and adenosine receptor subtypes involved in this process are largely unknown. In this study, we ...

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Inhibition of pluripotent stem cell-derived teratoma formation by small molecules [Cell Biology]

27-08-2013 | Mi-Ok Lee; Sung Hwan Moon; Ho-Chang Jeong; Ji-Yeon Yi; Tae-Hee Lee; Sung Han Shim; Yong-Hee Rhee; Sang-Hun Lee; Seok ..., Proceedings of the National Academy of Sciences current issue, 2013

The future of safe cell-based therapy rests on overcoming teratoma/tumor formation, in particular when using human pluripotent stem cells (hPSCs), such as human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs). Because the presence of a few remaining undifferentiated ...

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Mechanistic patient-specific predictive correlation of tumor drug response with microenvironment and perfusion measurements [Biophysics and Computational Biology]

27-08-2013 | Jennifer Pascal; Elaine L. Bearer; Zhihui Wang; Eugene J. Koay; Steven A. Curley; Vittorio Cristini, Proceedings of the National Academy of Sciences current issue, 2013

Physical properties of the microenvironment influence penetration of drugs into tumors. Here, we develop a mathematical model to predict the outcome of chemotherapy based on the physical laws of diffusion. The most important parameters in the model are the volume fraction occupied by tumor blood ...

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Immunization of fucose-containing polysaccharides from Reishi mushroom induces antibodies to tumor-associated Globo H-series epitopes [Biochemistry]

20-08-2013 | Shih-Fen Liao; Chi-Hui Liang; Ming-Yi Ho; Tsui-Ling Hsu; Tsung-I Tsai; Yves S.-Y. Hsieh; Chih-Ming Tsai; Shiou-Ting ..., Proceedings of the National Academy of Sciences current issue, 2013

Carbohydrate-based vaccines have shown therapeutic efficacy for infectious disease and cancer. The mushroom Ganoderma lucidum (Reishi) containing complex polysaccharides has been used as antitumor supplement, but the mechanism of immune response has rarely been studied. Here, we show that the ...

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Vascular endothelial growth factor-dependent spatiotemporal dual roles of placental growth factor in modulation of angiogenesis and tumor growth [Medical Sciences]

20-08-2013 | Xiaojuan Yang; Yin Zhang; Yunlong Yang; Sharon Lim; Ziquan Cao; Janusz Rak; Yihai Cao, Proceedings of the National Academy of Sciences current issue, 2013

Placental growth factor (PlGF) remodels tumor vasculatures toward a normalized phenotype, which affects tumor growth, invasion and drug responses. However, the coordinative and spatiotemporal relation between PlGF and VEGF in modulation of tumor angiogenesis and vascular remodeling is less ...

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Proteasome activator complex PA28 identified as an accessible target in prostate cancer by in vivo selection of human antibodies [Applied Biological Sciences]

20-08-2013 | David Sánchez-Martín; Jorge Martínez-Torrecuadrada; Tambet Teesalu; Kazuki N. Sugahara; Ana Alvarez-Cienfuegos; Pila ..., Proceedings of the National Academy of Sciences current issue, 2013

Antibody cancer therapies rely on systemically accessible targets and suitable antibodies that exert a functional activity or deliver a payload to the tumor site. Here, we present proof-of-principle of in vivo selection of human antibodies in tumor-bearing mice that identified a tumor-specific ...

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SIRT2 directs the replication stress response through CDK9 deacetylation [Medical Sciences]

13-08-2013 | Hui Zhang; Seong-Hoon Park; Brooke G. Pantazides; Oleksandra Karpiuk; Matthew D. Warren; Claire W. Hardy; Duc M. Duo ..., Proceedings of the National Academy of Sciences current issue, 2013

Sirtuin 2 (SIRT2) is a sirtuin family deacetylase that directs acetylome signaling, protects genome integrity, and is a murine tumor suppressor. We show that SIRT2 directs replication stress responses by regulating the activity of cyclin-dependent kinase 9 (CDK9), a protein required for recovery ...

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