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624 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancer [Cell Biology]

19-Jan-2016 | Jaekwang Jeong; Joshua N. VanHouten; Pamela Dann; Wonnam Kim; Catherine Sullivan; Herbert Yu; Lance Liotta; Virginia ..., Proceedings of the National Academy of Sciences current issue, 2016

In the lactating mammary gland, the plasma membrane calcium ATPase2 (PMCA2) transports milk calcium. Its expression is activated in breast cancers, where high tumor levels predict increased mortality. We find that PMCA2 expression correlates with HER2 levels in breast cancers and that PMCA2 ...

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Combination OX40 agonism/CTLA-4 blockade with HER2 vaccination reverses T-cell anergy and promotes survival in tumor-bearing mice [Immunology and Inflammation]

19-Jan-2016 | Stefanie N. Linch; Melissa J. Kasiewicz; Michael J. McNamara; Ian F. Hilgart-Martiszus; Mohammad Farhad; William L. ..., Proceedings of the National Academy of Sciences current issue, 2016

Immunotherapy is gathering momentum as a primary therapy for cancer patients. However, monotherapies have limited efficacy in improving outcomes and benefit only a subset of patients. Combination therapies targeting multiple pathways can augment an immune response to improve survival further. ...

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Bioengineered yeast-derived vacuoles with enhanced tissue-penetrating ability for targeted cancer therapy [Medical Sciences]

19-Jan-2016 | Vipul Gujrati; Miriam Lee; Young-Joon Ko; Sangeun Lee; Daejin Kim; Hyungjun Kim; Sukmo Kang; Soyoung Lee; Jinjoo Kim ..., Proceedings of the National Academy of Sciences current issue, 2016

Despite the appreciable success of synthetic nanomaterials for targeted cancer therapy in preclinical studies, technical challenges involving their large-scale, cost-effective production and intrinsic toxicity associated with the materials, as well as their inability to penetrate tumor tissues ...

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EGFR phosphorylates FAM129B to promote Ras activation [Cell Biology]

19-Jan-2016 | Haitao Ji; Jong-Ho Lee; Yugang Wang; Yilin Pang; Tao Zhang; Yan Xia; Lianjin Zhong; Jianxin Lyu; Zhimin Lu, Proceedings of the National Academy of Sciences current issue, 2016

Ras GTPase-activating proteins (GAPs) are important regulators for Ras activation, which is instrumental in tumor development. However, the mechanism underlying this regulation remains elusive. We demonstrate here that activated EGFR phosphorylates the Y593 residue of the protein known as family ...

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Heparanase-neutralizing antibodies attenuate lymphoma tumor growth and metastasis [Medical Sciences]

19-Jan-2016 | Marina Weissmann; Gil Arvatz; Netanel Horowitz; Sari Feld; Inna Naroditsky; Yi Zhang; Mary Ng; Edward Hammond; Eviat ..., Proceedings of the National Academy of Sciences current issue, 2016

Heparanase is an endoglycosidase that cleaves heparan sulfate side chains of proteoglycans, resulting in disassembly of the extracellular matrix underlying endothelial and epithelial cells and associating with enhanced cell invasion and metastasis. Heparanase expression is induced in carcinomas ...

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Dysregulated YAP1/TAZ and TGF-{beta} signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice [Medical Sciences]

05-Jan-2016 | Miki Nishio; Keishi Sugimachi; Hiroki Goto; Jia Wang; Takumi Morikawa; Yosuke Miyachi; Yusuke Takano; Hiroki Hikasa; ..., Proceedings of the National Academy of Sciences current issue, 2016

Mps One Binder Kinase Activator (MOB)1A/1B are core components of the Hippo pathway that coactivate large tumor suppressor homolog (LATS) kinases. Mob1a/1b double deficiency in mouse liver (LMob1DKO) results in hyperplasia of oval cells and immature cholangiocytes accompanied by inflammatory cell ...

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Site-specifically labeled CA19.9-targeted immunoconjugates for the PET, NIRF, and multimodal PET/NIRF imaging of pancreatic cancer [Chemistry]

29-Dec-2015 | Jacob L. Houghton; Brian M. Zeglis; Dalya Abdel-Atti; Robert Aggeler; Ritsuko Sawada; Brian J. Agnew; Wolfgang W. Sc ..., Proceedings of the National Academy of Sciences current issue, 2015

Molecular imaging agents for preoperative positron emission tomography (PET) and near-infrared fluorescent (NIRF)-guided delineation of surgical margins could greatly enhance the diagnosis, staging, and resection of pancreatic cancer. PET and NIRF optical imaging offer complementary clinical ...

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Lung inflammation promotes metastasis through neutrophil protease-mediated degradation of Tsp-1 [Immunology and Inflammation]

29-Dec-2015 | Tina El Rayes; Raúl Catena; Sharrell Lee; Marcin Stawowczyk; Natasha Joshi; Claudia Fischbach; Charles A. Powell; An ..., Proceedings of the National Academy of Sciences current issue, 2015

Inflammation is inextricably associated with primary tumor progression. However, the contribution of inflammation to tumor outgrowth in metastatic organs has remained underexplored. Here, we show that extrinsic inflammation in the lungs leads to the recruitment of bone marrow-derived neutrophils, ...

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Lymphomagenic CARD11/BCL10/MALT1 signaling drives malignant B-cell proliferation via cooperative NF-{kappa}B and JNK activation [Immunology and Inflammation]

29-Dec-2015 | Nathalie Knies; Begüm Alankus; Andre Weilemann; Alexandar Tzankov; Kristina Brunner; Tanja Ruff; Marcus Kremer; Ulri ..., Proceedings of the National Academy of Sciences current issue, 2015

The aggressive activated B cell-like subtype of diffuse large B-cell lymphoma is characterized by aberrant B-cell receptor (BCR) signaling and constitutive nuclear factor kappa-B (NF-κB) activation, which is required for tumor cell survival. BCR-induced NF-κB activation requires caspase ...

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STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity [Immunology and Inflammation]

15-Dec-2015 | Olivier Demaria; Aude De Gassart; Sanja Coso; Nicolas Gestermann; Jeremy Di Domizio; Lukas Flatz; Olivier Gaide; Oli ..., Proceedings of the National Academy of Sciences current issue, 2015

Spontaneous CD8 T-cell responses occur in growing tumors but are usually poorly effective. Understanding the molecular and cellular mechanisms that drive these responses is of major interest as they could be exploited to generate a more efficacious antitumor immunity. As such, stimulator of IFN ...

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