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528 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

TSPAN12 is a critical factor for cancer-fibroblast cell contact-mediated cancer invasion [Medical Sciences]

30-Dec-2014 | Ryo Otomo; Chihiro Otsubo; Yuko Matsushima-Hibiya; Makoto Miyazaki; Fumio Tashiro; Hitoshi Ichikawa; Takashi Kohno; ..., Proceedings of the National Academy of Sciences current issue, 2014

Communication between cancer cells and their microenvironment controls cancer progression. Although the tumor suppressor p53 functions in a cell-autonomous manner, it has also recently been shown to function in a non–cell-autonomous fashion. Although functional defects have been reported in p53 ...

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In vivo anticancer activity of rhomboidal Pt(II) metallacycles [Chemistry]

30-Dec-2014 | Ivan V. Grishagin; J. Bryant Pollock; Swati Kushal; Timothy R. Cook; Peter J. Stang; Bogdan Z. Olenyuk, Proceedings of the National Academy of Sciences current issue, 2014

The development of novel antitumor agents that have high efficacy in suppressing tumor growth, have low toxicity to nontumor tissues, and exhibit rapid localization in the targeted tumor sites is an ongoing avenue of research at the interface of chemistry, cancer biology, and pharmacology. ...

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A long noncoding RNA connects c-Myc to tumor metabolism [Medical Sciences]

30-Dec-2014 | Chiu-Lien Hung; Ling-Yu Wang; Yen-Ling Yu; Hong-Wu Chen; Shiv Srivastava; Gyorgy Petrovics; Hsing-Jien Kung, Proceedings of the National Academy of Sciences current issue, 2014

Long noncoding RNAs (lncRNAs) have been implicated in a variety of physiological and pathological processes, including cancer. In prostate cancer, prostate cancer gene expression marker 1 (PCGEM1) is an androgen-induced prostate-specific lncRNA whose overexpression is highly associated with ...

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Licensed human natural killer cells aid dendritic cell maturation via TNFSF14/LIGHT [Immunology and Inflammation]

30-Dec-2014 | Tim D. Holmes; Erica B. Wilson; Emma V. I. Black; Andrew V. Benest; Candida Vaz; Betty Tan; Vivek M. Tanavde; Graham ..., Proceedings of the National Academy of Sciences current issue, 2014

Interactions between natural killer (NK) cells and dendritic cells (DCs) aid DC maturation and promote T-cell responses. Here, we have analyzed the response of human NK cells to tumor cells, and we identify a pathway by which NK–DC interactions occur. Gene expression profiling of tumor-responsive ...

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Targeting osteosarcoma [Medical Sciences]

23-Dec-2014 | Darien E. Reed; Kevan M. Shokat, Proceedings of the National Academy of Sciences current issue, 2014

Small-molecule targeted therapies have significantly improved the treatment landscape for many cancers. When a patient’s tumor expresses the protein kinase BCR-ABL or the protein kinase BRAFV600E, or overexpresses the androgen receptor, we now know what to do: treat with the corresponding small ...

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Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma [Medical Sciences]

23-Dec-2014 | Jennifer A. Perry; Adam Kiezun; Peter Tonzi; Eliezer M. Van Allen; Scott L. Carter; Sylvan C. Baca; Glenn S. Cowley; ..., Proceedings of the National Academy of Sciences current issue, 2014

Osteosarcoma is the most common primary bone tumor, yet there have been no substantial advances in treatment or survival in three decades. We examined 59 tumor/normal pairs by whole-exome, whole-genome, and RNA-sequencing. Only the TP53 gene was mutated at significant frequency across all ...

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Genomic and functional analysis of leukemic transformation of myeloproliferative neoplasms [Genetics]

16-Dec-2014 | Raajit Rampal; Jihae Ahn; Omar Abdel-Wahab; Michelle Nahas; Kai Wang; Doron Lipson; Geoff A. Otto; Roman Yelensky; T ..., Proceedings of the National Academy of Sciences current issue, 2014

Patients with myeloproliferative neoplasms (MPNs) are at significant, cumulative risk of leukemic transformation to acute myeloid leukemia (AML), which is associated with adverse clinical outcome and resistance to standard AML therapies. We performed genomic profiling of post-MPN AML samples; ...

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Bisphosphonates inactivate human EGFRs to exert antitumor actions [Medical Sciences]

16-Dec-2014 | Tony Yuen; Agnes Stachnik; Jameel Iqbal; Miriam Sgobba; Yogesh Gupta; Ping Lu; Graziana Colaianni; Yaoting Ji; Ling- ..., Proceedings of the National Academy of Sciences current issue, 2014

Bisphosphonates are the most commonly prescribed medicines for osteoporosis and skeletal metastases. The drugs have also been shown to reduce cancer progression, but only in certain patient subgroups, suggesting that there is a molecular entity that mediates bisphosphonate action on tumor cells. ...

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Dissecting the clonal origins of childhood acute lymphoblastic leukemia by single-cell genomics [Genetics]

16-Dec-2014 | Charles Gawad; Winston Koh; Stephen R. Quake, Proceedings of the National Academy of Sciences current issue, 2014

Many cancers have substantial genomic heterogeneity within a given tumor, and to fully understand that diversity requires the ability to perform single cell analysis. We performed targeted sequencing of a panel of single nucleotide variants (SNVs), deletions, and IgH sequences in 1,479 single ...

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Acquisition of an immunosuppressive protumorigenic macrophage phenotype depending on c-Jun phosphorylation [Immunology and Inflammation]

09-Dec-2014 | Simona Hefetz-Sela; Ilan Stein; Yair Klieger; Rinnat Porat; Moshe Sade-Feldman; Farid Zreik; Arnon Nagler; Orit Papp ..., Proceedings of the National Academy of Sciences current issue, 2014

The inflamed tumor microenvironment plays a critical role in tumorigenesis. However, the mechanisms through which immune cells, particularly macrophages, promote tumorigenesis have only been partially elucidated, and the full scope of signaling pathways supplying macrophages with protumorigenic ...

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