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519 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

Acquisition of an immunosuppressive protumorigenic macrophage phenotype depending on c-Jun phosphorylation [Immunology and Inflammation]

09-12-2014 | Simona Hefetz-Sela; Ilan Stein; Yair Klieger; Rinnat Porat; Moshe Sade-Feldman; Farid Zreik; Arnon Nagler; Orit Papp ..., Proceedings of the National Academy of Sciences current issue, 2014

The inflamed tumor microenvironment plays a critical role in tumorigenesis. However, the mechanisms through which immune cells, particularly macrophages, promote tumorigenesis have only been partially elucidated, and the full scope of signaling pathways supplying macrophages with protumorigenic ...

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Disruption of FAT10-MAD2 binding inhibits tumor progression [Medical Sciences]

09-12-2014 | Steven Setiawan Theng; Wei Wang; Way-Champ Mah; Cheryl Chan; Jingli Zhuo; Yun Gao; Haina Qin; Liangzhong Lim; Samuel ..., Proceedings of the National Academy of Sciences current issue, 2014

FAT10 (HLA-F-adjacent transcript 10) is a ubiquitin-like modifier that is commonly overexpressed in various tumors. It was found to play a role in mitotic regulation through its interaction with mitotic arrest-deficient 2 (MAD2). Overexpression of FAT10 promotes tumor growth and malignancy. Here, ...

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Inhibition of tumor cell proliferation and motility by fibroblasts is both contact and soluble factor dependent [Cell Biology]

02-12-2014 | Twana Alkasalias; Emilie Flaberg; Vladimir Kashuba; Andrey Alexeyenko; Tatiana Pavlova; Andrii Savchenko; Laszlo Sze ..., Proceedings of the National Academy of Sciences current issue, 2014

Normal human and murine fibroblasts can inhibit proliferation of tumor cells when cocultured in vitro. The inhibitory capacity varies depending on the donor and the site of origin of the fibroblast. We showed previously that effective inhibition requires formation of a morphologically intact ...

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NanoFlares for the detection, isolation, and culture of live tumor cells from human blood [Applied Biological Sciences]

02-12-2014 | Tiffany L. Halo; Kaylin M. McMahon; Nicholas L. Angeloni; Yilin Xu; Wei Wang; Alyssa B. Chinen; Dmitry Malin; Elena ..., Proceedings of the National Academy of Sciences current issue, 2014

Metastasis portends a poor prognosis for cancer patients. Primary tumor cells disseminate through the bloodstream before the appearance of detectable metastatic lesions. The analysis of cancer cells in blood—so-called circulating tumor cells (CTCs)—may provide unprecedented opportunities for ...

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The commonly used antimicrobial additive triclosan is a liver tumor promoter [Environmental Sciences]

02-12-2014 | Mei-Fei Yueh; Koji Taniguchi; Shujuan Chen; Ronald M. Evans; Bruce D. Hammock; Michael Karin; Robert H. Tukey, Proceedings of the National Academy of Sciences current issue, 2014

Triclosan [5-chloro-2-(2,4-dichlorophenoxy)phenol; TCS] is a synthetic, broad-spectrum antibacterial chemical used in a wide range of consumer products including soaps, cosmetics, therapeutics, and plastics. The general population is exposed to TCS because of its prevalence in a variety of daily ...

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Intravital imaging reveals distinct responses of depleting dynamic tumor-associated macrophage and dendritic cell subpopulations [Medical Sciences]

25-11-2014 | Marja Lohela; Amy-Jo Casbon; Aleksandra Olow; Lynn Bonham; Daniel Branstetter; Ning Weng; Jeffrey Smith; Zena Werb, Proceedings of the National Academy of Sciences current issue, 2014

Tumor-infiltrating inflammatory cells comprise a major part of the stromal microenvironment and support cancer progression by multiple mechanisms. High numbers of tumor myeloid cells correlate with poor prognosis in breast cancer and are coupled with the angiogenic switch and malignant ...

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Bap1 is essential for kidney function and cooperates with Vhl in renal tumorigenesis [Medical Sciences]

18-11-2014 | Shan-Shan Wang; Yi-Feng Gu; Nicholas Wolff; Karoliina Stefanius; Alana Christie; Anwesha Dey; Robert E. Hammer; Xian ..., Proceedings of the National Academy of Sciences current issue, 2014

Why different species are predisposed to different tumor spectra is not well understood. In particular, whether the physical location of tumor suppressor genes relative to one another influences tumor predisposition is unknown. Renal cancer presents a unique opportunity to explore this question. ...

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RUNX1 is essential for mesenchymal stem cell proliferation and myofibroblast differentiation [Cell Biology]

18-11-2014 | Woosook Kim; David A. Barron; Rebeca San Martin; Keith S. Chan; Linda L. Tran; Feng Yang; Steven J. Ressler; David R ..., Proceedings of the National Academy of Sciences current issue, 2014

Myofibroblasts are a key cell type in wound repair, cardiovascular disease, and fibrosis and in the tumor-promoting microenvironment. The high accumulation of myofibroblasts in reactive stroma is predictive of the rate of cancer progression in many different tumors, yet the cell types of origin ...

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The Runt-related transcription factor 1 in prostate cancer-associated fibroblasts [Cell Biology]

18-11-2014 | Hilary A. Coller, Proceedings of the National Academy of Sciences current issue, 2014

Although most carcinomas arise from a series of genetic alterations in epithelial cells, cancer is a disease that affects not just the transformed cells themselves, but the entire tissue. During tumor development, reciprocal signaling patterns between the cancer cells and the surrounding tissue ...

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BID mediates selective killing of APC-deficient cells in intestinal tumor suppression by nonsteroidal antiinflammatory drugs [Medical Sciences]

18-11-2014 | Brian Leibowitz; Wei Qiu; Monica E. Buchanan; Fangdong Zou; Philip Vernon; Mary P. Moyer; Xiao-Ming Yin; Robert E. S ..., Proceedings of the National Academy of Sciences current issue, 2014

Colorectal tumorigenesis is driven by genetic alterations in the adenomatous polyposis coli (APC) tumor suppressor pathway and effectively inhibited by nonsteroidal antiinflammatory drugs (NSAIDs). However, how NSAIDs prevent colorectal tumorigenesis has remained obscure. We found that the ...

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