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553 Newest Publications in proceedings of the national academy of sciences current issue

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Glycosylation profiles determine extravasation and disease-targeting properties of armed antibodies [Applied Biological Sciences]

17-Feb-2015 | Dario Venetz; Christian Hess; Chia-wei Lin; Markus Aebi; Dario Neri, Proceedings of the National Academy of Sciences current issue, 2015

The ability of antibodies to extravasate out of blood vessels is critical for therapeutic activity, because molecular targets for most diseases are located outside of the endothelial lining. By performing detailed biodistribution studies with a novel IL9-armed cancer-specific antibody, we ...

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Macrophages eat cancer cells using their own calreticulin as a guide: Roles of TLR and Btk [Immunology and Inflammation]

17-Feb-2015 | Mingye Feng; James Y. Chen; Rachel Weissman-Tsukamoto; Jens-Peter Volkmer; Po Yi Ho; Kelly M. McKenna; Samuel Cheshi ..., Proceedings of the National Academy of Sciences current issue, 2015

Macrophage-mediated programmed cell removal (PrCR) is an important mechanism of eliminating diseased and damaged cells before programmed cell death. The induction of PrCR by eat-me signals on tumor cells is countered by don’t-eat-me signals such as CD47, which binds macrophage signal-regulatory ...

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CryoEM and mutagenesis reveal that the smallest capsid protein cements and stabilizes Kaposi's sarcoma-associated herpesvirus capsid [Biophysics and Computational Biology]

17-Feb-2015 | Xinghong Dai; Danyang Gong; Yuchen Xiao; Ting-Ting Wu; Ren Sun; Z. Hong Zhou, Proceedings of the National Academy of Sciences current issue, 2015

With just one eighth the size of the major capsid protein (MCP), the smallest capsid protein (SCP) of human tumor herpesviruses—Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV)—is vital to capsid assembly, yet its mechanism of action is unknown. Here, by cryoEM of KSHV ...

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TCL1 targeting miR-3676 is codeleted with tumor protein p53 in chronic lymphocytic leukemia [Medical Sciences]

17-Feb-2015 | Veronica Balatti; Lara Rizzotto; Cecelia Miller; Alexey Palamarchuk; Paolo Fadda; Rosantony Pandolfo; Laura Z. Rasse ..., Proceedings of the National Academy of Sciences current issue, 2015

B-cell chronic lymphocytic leukemia (CLL) is the most common human leukemia and dysregulation of the T-cell leukemia/lymphoma 1 (TCL1) oncogene is a contributing event in the pathogenesis of the aggressive form of this disease based on transgenic mouse studies. To determine a role of microRNAs on ...

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Aberrant recombination and repair during immunoglobulin class switching in BRCA1-deficient human B cells [Immunology and Inflammation]

17-Feb-2015 | Andrea Björkman; Per Qvist; Likun Du; Margarita Bartish; Apostolos Zaravinos; Konstantinos Georgiou; Anders D. Børgl ..., Proceedings of the National Academy of Sciences current issue, 2015

Breast cancer type 1 susceptibility protein (BRCA1) has a multitude of functions that contribute to genome integrity and tumor suppression. Its participation in the repair of DNA double-strand breaks (DSBs) during homologous recombination (HR) is well recognized, whereas its involvement in the ...

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Heterogeneity for IGF-II production maintained by public goods dynamics in neuroendocrine pancreatic cancer [Medical Sciences]

10-Feb-2015 | Marco Archetti; Daniela A. Ferraro; Gerhard Christofori, Proceedings of the National Academy of Sciences current issue, 2015

The extensive intratumor heterogeneity revealed by sequencing cancer genomes is an essential determinant of tumor progression, diagnosis, and treatment. What maintains heterogeneity remains an open question because competition within a tumor leads to a strong selection for the fittest subclone. ...

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Src phosphorylation converts Mdm2 from a ubiquitinating to a neddylating E3 ligase [Biochemistry]

10-Feb-2015 | Christopher N. Batuello; Paula M. Hauck; Jaimie M. Gendron; Jason A. Lehman; Lindsey D. Mayo, Proceedings of the National Academy of Sciences current issue, 2015

Murine double minute-2 protein (Mdm2) is a multifaceted phosphorylated protein that plays a role in regulating numerous proteins including the tumor suppressor protein p53. Mdm2 binds to and is involved in conjugating either ubiquitin or Nedd8 (Neural precursor cell expressed, developmentally ...

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BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma model [Cell Biology]

10-Feb-2015 | Daniele Perna; Florian A. Karreth; Alistair G. Rust; Pedro A. Perez-Mancera; Mamunur Rashid; Francesco Iorio; Consta ..., Proceedings of the National Academy of Sciences current issue, 2015

BRAF (v-raf murine sarcoma viral oncogene homolog B) inhibitors elicit a transient anti-tumor response in ∼80% of BRAFV600-mutant melanoma patients that almost uniformly precedes the emergence of resistance. Here we used a mouse model of melanoma in which melanocyte-specific expression of ...

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Differential regulation of the Hippo pathway by adherens ȷunctions and apical-basal cell polarity modules [Cell Biology]

10-Feb-2015 | Chih-Chao Yang; Hillary K. Graves; Ivan M. Moya; Chunyao Tao; Fisun Hamaratoglu; Andrew B. Gladden; Georg Halder, Proceedings of the National Academy of Sciences current issue, 2015

Adherens junctions (AJs) and cell polarity complexes are key players in the establishment and maintenance of apical–basal cell polarity. Loss of AJs or basolateral polarity components promotes tumor formation and metastasis. Recent studies in vertebrate models show that loss of AJs or loss of the ...

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p53 at the endoplasmic reticulum regulates apoptosis in a Ca2+-dependent manner [Cell Biology]

10-Feb-2015 | Carlotta Giorgi; Massimo Bonora; Giovanni Sorrentino; Sonia Missiroli; Federica Poletti; Jan M. Suski; Fabian Galind ..., Proceedings of the National Academy of Sciences current issue, 2015

The tumor suppressor p53 is a key protein in preventing cell transformation and tumor progression. Activated by a variety of stimuli, p53 regulates cell-cycle arrest and apoptosis. Along with its well-documented transcriptional control over cell-death programs within the nucleus, p53 exerts ...

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