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500 Newest Publications in proceedings of the national academy of sciences current issue

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matching the following criteria

Seriniquinone, a selective anticancer agent, induces cell death by autophagocytosis, targeting the cancer-protective protein dermcidin [Pharmacology]

14-10-2014 | Lynnie Trzoss; Takashi Fukuda; Letícia V. Costa-Lotufo; Paula Jimenez; James J. La Clair; William Fenical, Proceedings of the National Academy of Sciences current issue, 2014

Natural products continue to provide vital treatment options for cancer. Although their translation into chemotherapeutics is complex, collaborative programs continue to deliver productive pipelines for cancer chemotherapy. A new natural product, seriniquinone, isolated from a marine bacterium of ...

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Modeling tumor heterogeneity and predicting effective combined therapies through computational optimization algorithms [Biological Sciences]

14-10-2014 | Francisco J. Azuaje, Proceedings of the National Academy of Sciences current issue, 2014

Zhao et al. (1) report a computational method that models intratumor heterogeneity and its responses to drug combinations. The authors computationally simulated intratumor heterogeneity by mixing samples derived from a large collection of lymphoma cells, which were previously infected with ...

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ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers [Cell Biology]

14-10-2014 | Alexander Augustyn; Mark Borromeo; Tao Wang; Junya Fujimoto; Chunli Shao; Patrick D. Dospoy; Victoria Lee; Christoph ..., Proceedings of the National Academy of Sciences current issue, 2014

Aggressive neuroendocrine lung cancers, including small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC), represent an understudied tumor subset that accounts for approximately 40,000 new lung cancer cases per year in the United States. No targeted therapy exists for these tumors. ...

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Human DNA tumor viruses generate alternative reading frame proteins through repeat sequence recoding [Microbiology]

14-10-2014 | Hyun Jin Kwun; Tuna Toptan; Suzane Ramos da Silva; John F. Atkins; Patrick S. Moore; Yuan Chang, Proceedings of the National Academy of Sciences current issue, 2014

Kaposi’s sarcoma-associated herpesvirus (KSHV) and Epstein–Barr virus (EBV) are human DNA tumor viruses that express nuclear antigens [latency-associated nuclear antigen 1 (LANA1) and Epstein–Barr nuclear antigen 1 (EBNA1)] necessary to maintain and replicate the viral genome. We report here that ...

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A 3D matrix platform for the rapid generation of therapeutic anti-human carcinoma monoclonal antibodies [Medical Sciences]

14-10-2014 | David T. Dudley; Xiao-Yan Li; Casey Y. Hu; Celina G. Kleer; Amanda L. Willis; Stephen J. Weiss, Proceedings of the National Academy of Sciences current issue, 2014

Efforts to develop unbiased screens for identifying novel function-blocking monoclonal antibodies (mAbs) in human carcinomatous states have been hampered by the limited ability to design in vitro models that recapitulate tumor cell behavior in vivo. Given that only invasive carcinoma cells gain ...

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Modeling putative therapeutic implications of exosome exchange between tumor and immune cells [Biophysics and Computational Biology]

07-10-2014 | Mingyang Lu; Bin Huang; Samir M. Hanash; José N. Onuchic; Eshel Ben-Jacob, Proceedings of the National Academy of Sciences current issue, 2014

Development of effective strategies to mobilize the immune system as a therapeutic modality in cancer necessitates a better understanding of the contribution of the tumor microenvironment to the complex interplay between cancer cells and the immune response. Recently, effort has been directed at ...

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Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress [Genetics]

16-09-2014 | Floris Foijer; Stephanie Z. Xie; Judith E. Simon; Petra L. Bakker; Nathalie Conte; Stephanie H. Davis; Eva Kregel; J ..., Proceedings of the National Academy of Sciences current issue, 2014

Aneuploidy is a hallmark of human solid cancers that arises from errors in mitosis and results in gain and loss of oncogenes and tumor suppressors. Aneuploidy poses a growth disadvantage for cells grown in vitro, suggesting that cancer cells adapt to this burden. To understand better the ...

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Translation initiation factor eIF4F modifies the dexamethasone response in multiple myeloma [Genetics]

16-09-2014 | Francis Robert; William Roman; Alexandre Bramoullé; Christof Fellmann; Anne Roulston; Chaim Shustik; John A. Porco, ..., Proceedings of the National Academy of Sciences current issue, 2014

Enhanced protein synthesis capacity is associated with increased tumor cell survival, proliferation, and resistance to chemotherapy. Cancers like multiple myeloma (MM), which display elevated activity in key translation regulatory nodes, such as the PI3K/mammalian target of rapamycin and ...

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A TNFSF15 disease-risk polymorphism increases pattern-recognition receptor-induced signaling through caspase-8-induced IL-1 [Immunology and Inflammation]

16-09-2014 | Matija Hedl; Clara Abraham, Proceedings of the National Academy of Sciences current issue, 2014

Inflammatory diseases are characterized by dysregulated cytokine production. Altered functions for most risk loci, including the inflammatory bowel disease and leprosy-associated tumor necrosis factor ligand superfamily member 15 (TNFSF15) region, are unclear. Regulation of ...

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Correction for Turnquist et al., STAT1-induced ASPP2 transcription identifies a link between neuroinflammation, cell polarity, and tumor suppression [Corrections]

16-09-2014 | Proceedings of the National Academy of Sciences current issue, 2014

CELL BIOLOGY Correction for “STAT1-induced ASPP2 transcription identifies a link between neuroinflammation, cell polarity, and tumor suppression,” by Casmir Turnquist, Yihua Wang, David T. Severson, Shan Zhong, Bin Sun, Jingyi Ma, Stefan N. Constaninescu, Olaf Ansorge, Helen B. Stolp, Zoltán ...

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