14-05-2013 | Jean-Christophe Pignon; Chiara Grisanzio; Yan Geng; Jiaxi Song; Ramesh A. Shivdasani; Sabina Signoretti, Proceedings of the National Academy of Sciences current issue, 2013

The tumor protein p63 (p63), and more specifically the NH2-terminal truncated (ΔN) p63 isoform, is a marker of basal epithelial cells and is required for normal development of several epithelial tissues, including the bladder and prostate glands. Although p63-expressing cells are proposed to ...

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14-05-2013 | Rebecca Berlant Liu; Boris Engels; Karin Schreiber; Cezary Ciszewski; Andrea Schietinger; Hans Schreiber; Bana Jabri, Proceedings of the National Academy of Sciences current issue, 2013

A major challenge of cancer immunotherapy is the persistence and outgrowth of subpopulations that lose expression of the target antigen. IL-15 is a potent cytokine that can promote organ-specific autoimmunity when up-regulated on tissue cells. Here we report that T cells eradicated 2-wk-old ...

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07-05-2013 | Eun-Young Kho; Hsu-Kun Wang; N. Sanjib Banerjee; Thomas R. Broker; Louise T. Chow, Proceedings of the National Academy of Sciences current issue, 2013

Human papillomaviruses (HPVs) amplify in differentiated strata of a squamous epithelium. The HPV E7 protein destabilizes the p130/retinoblastoma susceptibility protein family of tumor suppressors and reactivates S-phase reentry, thereby facilitating viral DNA amplification. The high-risk HPV ...

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07-05-2013 | Sarah K. Knutson; Natalie M. Warholic; Tim J. Wigle; Christine R. Klaus; Christina J. Allain; Alejandra Raimondi; Ma ..., Proceedings of the National Academy of Sciences current issue, 2013

Inactivation of the switch/sucrose nonfermentable complex component SMARCB1 is extremely prevalent in pediatric malignant rhabdoid tumors (MRTs) or atypical teratoid rhabdoid tumors. This alteration is hypothesized to confer oncogenic dependency on EZH2 in these cancers. We report the ...

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07-05-2013 | Patrick J. Murphy; Benjamin R. Cipriany; Christopher B. Wallin; Chan Yang Ju; Kylan Szeto; James A. Hagarman; Jaime ..., Proceedings of the National Academy of Sciences current issue, 2013

Proper placement of epigenetic marks on DNA and histones is fundamental to normal development, and perturbations contribute to a variety of disease states. Combinations of marks act together to control gene expression; therefore, detecting their colocalization is important, but because of ...

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30-04-2013 | Xuehong Yu; Tom C. M. Seegar; Annamarie C. Dalton; Dorothea Tzvetkova-Robev; Yehuda Goldgur; Kanagalaghatta R. Rajas ..., Proceedings of the National Academy of Sciences current issue, 2013

Angiogenesis is a complex cellular process involving multiple regulatory growth factors and growth factor receptors. Among them, the ligands for the endothelial-specific tunica intima endothelial receptor tyrosine kinase 2 (Tie2) receptor kinase, angiopoietin-1 (Ang1) and Ang2, play essential ...

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30-04-2013 | Alessandro Terrinoni; Valeria Serra; Ernesto Bruno; Andreas Strasser; Elizabeth Valente; Elsa R. Flores; Hans van Bo ..., Proceedings of the National Academy of Sciences current issue, 2013

The ectodermal dysplasias are a group of inherited autosomal dominant syndromes associated with heterozygous mutations in the Tumor Protein p63 (TRP63) gene. Here we show that, in addition to their epidermal pathology, a proportion of these patients have distinct levels of deafness. ...

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30-04-2013 | Paulina Kucharzewska; Helena C. Christianson; Johanna E. Welch; Katrin J. Svensson; Erik Fredlund; Markus Ringnér; M ..., Proceedings of the National Academy of Sciences current issue, 2013

Hypoxia, or low oxygen tension, is a major regulator of tumor development and aggressiveness. However, how cancer cells adapt to hypoxia and communicate with their surrounding microenvironment during tumor development remain important questions. Here, we show that secreted vesicles with ...

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23-04-2013 | Frida Danielsson; Marie Skogs; Mikael Huss; Elton Rexhepaj; Gillian O’Hurley; Daniel Klevebring; Fredrik Pontén; Ann ..., Proceedings of the National Academy of Sciences current issue, 2013

The transformation of normal cells to malignant, metastatic tumor cells is a multistep process caused by the sequential acquirement of genetic changes. To identify these changes, we compared the transcriptomes and levels and distribution of proteins in a four-stage cell model of isogenically ...

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23-04-2013 | Shi Zhong; Karolina Malecek; Laura A. Johnson; Zhiya Yu; Eleazar Vega-Saenz de Miera; Farbod Darvishian; Katelyn McG ..., Proceedings of the National Academy of Sciences current issue, 2013

T cells expressing antigen-specific T-cell receptors (TCRs) can mediate effective tumor regression, but they often also are accompanied by autoimmune responses. To determine the TCR affinity threshold defining the optimal balance between effective antitumor activity and autoimmunity in vivo, ...

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