My watch list
my.chemeurope.com  
Login  

586 Newest Publications in proceedings of the national academy of sciences current issue

rss
matching the following criteria

TLR4 has a TP53-dependent dual role in regulating breast cancer cell growth [Cell Biology]

23-Jun-2015 | Svasti Haricharan; Powel Brown, Proceedings of the National Academy of Sciences current issue, 2015

Breast cancer is a leading cause of cancer-related death, and it is important to understand pathways that drive the disease to devise effective therapeutic strategies. Our results show that Toll-like receptor 4 (TLR4) drives breast cancer cell growth differentially based on the presence of TP53, ...

more

Inference of transcriptional regulation in cancers [Biophysics and Computational Biology]

23-Jun-2015 | Peng Jiang; Matthew L. Freedman; Jun S. Liu; Xiaole Shirley Liu, Proceedings of the National Academy of Sciences current issue, 2015

Despite the rapid accumulation of tumor-profiling data and transcription factor (TF) ChIP-seq profiles, efforts integrating TF binding with the tumor-profiling data to understand how TFs regulate tumor gene expression are still limited. To systematically search for cancer-associated TFs, we ...

more

Systematic transcriptome analysis reveals tumor-specific isoforms for ovarian cancer diagnosis and therapy [Medical Sciences]

09-Jun-2015 | Christian L. Barrett; Christopher DeBoever; Kristen Jepsen; Cheryl C. Saenz; Dennis A. Carson; Kelly A. Frazer, Proceedings of the National Academy of Sciences current issue, 2015

Tumor-specific molecules are needed across diverse areas of oncology for use in early detection, diagnosis, prognosis and therapy. Large and growing public databases of transcriptome sequencing data (RNA-seq) derived from tumors and normal tissues hold the potential of yielding tumor-specific ...

more

In vitro model for lytic replication, latency, and transformation of an oncogenic alphaherpesvirus [Microbiology]

09-Jun-2015 | Julia Schermuly; Annachiara Greco; Sonja Härtle; Nikolaus Osterrieder; Benedikt B. Kaufer; Bernd Kaspers, Proceedings of the National Academy of Sciences current issue, 2015

Marek’s disease virus (MDV) is an alphaherpesvirus that causes deadly T-cell lymphomas in chickens and serves as a natural small animal model for virus-induced tumor formation. In vivo, MDV lytically replicates in B cells that transfer the virus to T cells in which the virus establishes latency. ...

more

VEGF-B promotes cancer metastasis through a VEGF-A-independent mechanism and serves as a marker of poor prognosis for cancer patients [Medical Sciences]

02-Jun-2015 | Xiaojuan Yang; Yin Zhang; Kayoko Hosaka; Patrik Andersson; Jian Wang; Fredrik Tholander; Ziquan Cao; Hiromasa Morika ..., Proceedings of the National Academy of Sciences current issue, 2015

The biological functions of VEGF-B in cancer progression remain poorly understood. Here, we report that VEGF-B promotes cancer metastasis through the remodeling of tumor microvasculature. Knockdown of VEGF-B in tumors resulted in increased perivascular cell coverage and impaired pulmonary ...

more

In This Issue [This Week in PNAS]

26-May-2015 | Proceedings of the National Academy of Sciences current issue, 2015

Singular roles of checkpoint proteins SEM of killer T cell recognizing a tumor cell (blue). Image courtesy of Drew Pardoll (PNAS, 2002). Checkpoint proteins, which adorn the surface of some immune cells, help keep autoimmune diseases at bay by fine-tuning the activation of T cells, the immune ...

more

Multisite interaction with Sufu regulates Ci/Gli activity through distinct mechanisms in Hh signal transduction [Developmental Biology]

19-May-2015 | Yuhong Han; Qing Shi; Jin Jiang, Proceedings of the National Academy of Sciences current issue, 2015

The tumor suppressor protein Suppressor of fused (Sufu) plays a conserved role in the Hedgehog (Hh) signaling pathway by inhibiting Cubitus interruptus (Ci)/Glioma-associated oncogene homolog (Gli) transcription factors, but the molecular mechanism by which Sufu inhibits Ci/Gli activity remains ...

more

IL-33 activates tumor stroma to promote intestinal polyposis [Immunology and Inflammation]

12-May-2015 | Rebecca L. Maywald; Stephanie K. Doerner; Luca Pastorelli; Carlo De Salvo; Susan M. Benton; Emily P. Dawson; Denise ..., Proceedings of the National Academy of Sciences current issue, 2015

Tumor epithelial cells develop within a microenvironment consisting of extracellular matrix, growth factors, and cytokines produced by nonepithelial stromal cells. In response to paracrine signals from tumor epithelia, stromal cells modify the microenvironment to promote tumor growth and ...

more

QnAs with Patrick Moore [QnAs]

12-May-2015 | Jennifer Viegas, Proceedings of the National Academy of Sciences current issue, 2015

Since its inception just over a century ago, the field of tumor virology has provided insights into the causes for many cancers. Patrick Moore, director of the Cancer Virology Program at the University of Pittsburgh, is a leading contributor to the field, having codiscovered two of the seven ...

more

Noninvasive imaging of immune responses [Immunology and Inflammation]

12-May-2015 | Mohammad Rashidian; Edmund J. Keliher; Angelina M. Bilate; Joao N. Duarte; Gregory R. Wojtkiewicz; Johanne Tracey Ja ..., Proceedings of the National Academy of Sciences current issue, 2015

At their margins, tumors often contain neutrophils, dendritic cells, and activated macrophages, which express class II MHC and CD11b products. The interplay between stromal cells, tumor cells, and migratory cells such as lymphocytes creates opportunities for noninvasive imaging of immune ...

more

Page 1 From 59
Subscribe to e-mail updates relating to your search

You will receive via e-mail the latest search results matching your search criteria. This service is free of charge and can be cancelled at any time.

Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE