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569 Newest Publications in proceedings of the national academy of sciences current issue

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CD14-expressing cancer cells establish the inflammatory and proliferative tumor microenvironment in bladder cancer [Immunology and Inflammation]

14-Apr-2015 | Ming T. Cheah; James Y. Chen; Debashis Sahoo; Humberto Contreras-Trujillo; Anne K. Volkmer; Ferenc A. Scheeren; Jens ..., Proceedings of the National Academy of Sciences current issue, 2015

Nonresolving chronic inflammation at the neoplastic site is consistently associated with promoting tumor progression and poor patient outcomes. However, many aspects behind the mechanisms that establish this tumor-promoting inflammatory microenvironment remain undefined. Using bladder cancer (BC) ...

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TCR contact residue hydrophobicity is a hallmark of immunogenic CD8+ T cell epitopes [Medical Sciences]

07-Apr-2015 | Diego Chowell; Sri Krishna; Pablo D. Becker; Clément Cocita; Jack Shu; Xuefang Tan; Philip D. Greenberg; Linda S. Kl ..., Proceedings of the National Academy of Sciences current issue, 2015

Despite the availability of major histocompatibility complex (MHC)-binding peptide prediction algorithms, the development of T-cell vaccines against pathogen and tumor antigens remains challenged by inefficient identification of immunogenic epitopes. CD8+ T cells must distinguish immunogenic ...

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Enhanced expression of DNA polymerase eta contributes to cisplatin resistance of ovarian cancer stem cells [Genetics]

07-Apr-2015 | Amit Kumar Srivastava; Chunhua Han; Ran Zhao; Tiantian Cui; Yuntao Dai; Charlene Mao; Weiqiang Zhao; Xiaoli Zhang; J ..., Proceedings of the National Academy of Sciences current issue, 2015

Cancer stem cells (CSCs) with enhanced tumorigenicity and chemoresistance are believed to be responsible for treatment failure and tumor relapse in ovarian cancer patients. However, it is still unclear how CSCs survive DNA-damaging agent treatment. Here, we report an elevated expression of DNA ...

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Lengthening and shortening of plasma DNA in hepatocellular carcinoma patients [Medical Sciences]

17-Mar-2015 | Peiyong Jiang; Carol W. M. Chan; K. C. Allen Chan; Suk Hang Cheng; John Wong; Vincent Wai-Sun Wong; Grace L. H. Wong ..., Proceedings of the National Academy of Sciences current issue, 2015

The analysis of tumor-derived circulating cell-free DNA opens up new possibilities for performing liquid biopsies for the assessment of solid tumors. Although its clinical potential has been increasingly recognized, many aspects of the biological characteristics of tumor-derived cell-free DNA ...

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BRUCE regulates DNA double-strand break response by promoting USP8 deubiquitination of BRIT1 [Cell Biology]

17-Mar-2015 | Chunmin Ge; Lixiao Che; Jinyu Ren; Raj K. Pandita; Jing Lu; Kaiyi Li; Tej K. Pandita; Chunying Du, Proceedings of the National Academy of Sciences current issue, 2015

The DNA damage response (DDR) is crucial for genomic integrity. BRIT1 (breast cancer susceptibility gene C terminus-repeat inhibitor of human telomerase repeat transcriptase expression), a tumor suppressor and early DDR factor, is recruited to DNA double-strand breaks (DSBs) by phosphorylated H2A ...

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Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer [Medical Sciences]

17-Mar-2015 | Anthony C. Faber; Anna F. Farago; Carlotta Costa; Anahita Dastur; Maria Gomez-Caraballo; Rebecca Robbins; Bethany L. ..., Proceedings of the National Academy of Sciences current issue, 2015

BH3 mimetics such as ABT-263 induce apoptosis in a subset of cancer models. However, these drugs have shown limited clinical efficacy as single agents in small-cell lung cancer (SCLC) and other solid tumor malignancies, and rational combination strategies remain underexplored. To develop a novel ...

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Antigen specificity can be irrelevant to immunocytokine efficacy and biodistribution [Applied Biological Sciences]

17-Mar-2015 | Alice Tzeng; Byron H. Kwan; Cary F. Opel; Tejas Navaratna; K. Dane Wittrup, Proceedings of the National Academy of Sciences current issue, 2015

Cytokine therapy can activate potent, sustained antitumor responses, but collateral toxicity often limits dosages. Although antibody–cytokine fusions (immunocytokines) have been designed with the intent to localize cytokine activity, systemic dose-limiting side effects are not fully ameliorated ...

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Circulating tumor-derived DNA is shorter than somatic DNA in plasma [Medical Sciences]

17-Mar-2015 | Florent Mouliere; Nitzan Rosenfeld, Proceedings of the National Academy of Sciences current issue, 2015

Circulating tumor DNA (ctDNA) is now widely investigated as a biomarker in translational and clinical research (1). However, despite the growing field of clinical applications, the biology of ctDNA remains unclear. In trying to learn about the origins of ctDNA, nature provides us with very few ...

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Mutations in early follicular lymphoma progenitors are associated with suppressed antigen presentation [Genetics]

10-Mar-2015 | Michael R. Green; Shingo Kihira; Chih Long Liu; Ramesh V. Nair; Raheleh Salari; Andrew J. Gentles; Jonathan Irish; H ..., Proceedings of the National Academy of Sciences current issue, 2015

Follicular lymphoma (FL) is incurable with conventional therapies and has a clinical course typified by multiple relapses after therapy. These tumors are genetically characterized by B-cell leukemia/lymphoma 2 (BCL2) translocation and mutation of genes involved in chromatin modification. By ...

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Detecting cancers through tumor-activatable minicircles that lead to a detectable blood biomarker [Medical Sciences]

10-Mar-2015 | John A. Ronald; Hui-Yen Chuang; Anca Dragulescu-Andrasi; Sharon S. Hori; Sanjiv S. Gambhir, Proceedings of the National Academy of Sciences current issue, 2015

Earlier detection of cancers can dramatically improve the efficacy of available treatment strategies. However, despite decades of effort on blood-based biomarker cancer detection, many promising endogenous biomarkers have failed clinically because of intractable problems such as highly variable ...

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