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600 Newest Publications in proceedings of the national academy of sciences current issue

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Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype [Medical Sciences]

18-Aug-2015 | Haiquan Lu; Debangshu Samanta; Lisha Xiang; Huimin Zhang; Hongxia Hu; Ivan Chen; John W. Bullen; Gregg L. Semenza, Proceedings of the National Academy of Sciences current issue, 2015

Triple negative breast cancer (TNBC) accounts for 10–15% of all breast cancer but is responsible for a disproportionate share of morbidity and mortality because of its aggressive characteristics and lack of targeted therapies. Chemotherapy induces enrichment of breast cancer stem cells (BCSCs), ...

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Flow perfusion effects on three-dimensional culture and drug sensitivity of Ewing sarcoma [Medical Sciences]

18-Aug-2015 | Marco Santoro; Salah-Eddine Lamhamedi-Cherradi; Brian A. Menegaz; Joseph A. Ludwig; Antonios G. Mikos, Proceedings of the National Academy of Sciences current issue, 2015

Three-dimensional tumor models accurately describe different aspects of the tumor microenvironment and are readily available for mechanistic studies of tumor biology and for drug screening. Nevertheless, these systems often overlook biomechanical stimulation, another fundamental driver of tumor ...

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MALDI mass spectrometry imaging analysis of pituitary adenomas for near-real-time tumor delineation [Chemistry]

11-Aug-2015 | David Calligaris; Daniel R. Feldman; Isaiah Norton; Olutayo Olubiyi; Armen N. Changelian; Revaz Machaidze; Matthew L ..., Proceedings of the National Academy of Sciences current issue, 2015

We present a proof of concept study designed to support the clinical development of mass spectrometry imaging (MSI) for the detection of pituitary tumors during surgery. We analyzed by matrix-assisted laser desorption/ionization (MALDI) MSI six nonpathological (NP) human pituitary glands and 45 ...

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The isolation of an RNA aptamer targeting to p53 protein with single amino acid mutation [Medical Sciences]

11-Aug-2015 | Liang Chen; Farooq Rashid; Abdullah Shah; Hassaan M. Awan; Mingming Wu; An Liu; Jun Wang; Tao Zhu; Zhaofeng Luo; Ge Shan, Proceedings of the National Academy of Sciences current issue, 2015

p53, known as a tumor suppressor, is a DNA binding protein that regulates cell cycle, activates DNA repair proteins, and triggers apoptosis in multicellular animals. More than 50% of human cancers contain a mutation or deletion of the p53 gene, and p53R175 is one of the hot spots of p53...

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Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors [Cell Biology]

11-Aug-2015 | Anneleen Daemen; David Peterson; Nisebita Sahu; Ron McCord; Xiangnan Du; Bonnie Liu; Katarzyna Kowanetz; Rebecca Hon ..., Proceedings of the National Academy of Sciences current issue, 2015

Although targeting cancer metabolism is a promising therapeutic strategy, clinical success will depend on an accurate diagnostic identification of tumor subtypes with specific metabolic requirements. Through broad metabolite profiling, we successfully identified three highly distinct metabolic ...

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MicroRNA-224 promotes tumor progression in nonsmall cell lung cancer [Medical Sciences]

04-Aug-2015 | Ri Cui; Wei Meng; Hui-Lung Sun; Taewan Kim; Zhenqing Ye; Matteo Fassan; Young-Jun Jeon; Bin Li; Caterina Vicentini; ..., Proceedings of the National Academy of Sciences current issue, 2015

Lung cancer is the leading cause of cancer-related deaths worldwide. Despite advancements and improvements in surgical and medical treatments, the survival rate of lung cancer patients remains frustratingly poor. Local control for early-stage nonsmall cell lung cancer (NSCLC) has dramatically ...

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Detection of tumor-derived DNA in cerebrospinal fluid of patients with primary tumors of the brain and spinal cord [Medical Sciences]

04-Aug-2015 | Yuxuan Wang; Simeon Springer; Ming Zhang; K. Wyatt McMahon; Isaac Kinde; Lisa Dobbyn; Janine Ptak; Henry Brem; Kaiso ..., Proceedings of the National Academy of Sciences current issue, 2015

Cell-free DNA shed by cancer cells has been shown to be a rich source of putative tumor-specific biomarkers. Because cell-free DNA from brain and spinal cord tumors cannot usually be detected in the blood, we studied whether the cerebrospinal fluid (CSF) that bathes the CNS is enriched for tumor ...

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Dynamic epigenetic regulation of glioblastoma tumorigenicity through LSD1 modulation of MYC expression [Cell Biology]

28-Jul-2015 | David Kozono; Jie Li; Masayuki Nitta; Oltea Sampetrean; David Gonda; Deepa S. Kushwaha; Dmitry Merzon; Valya Ramakri ..., Proceedings of the National Academy of Sciences current issue, 2015

The available evidence suggests that the lethality of glioblastoma is driven by small subpopulations of cells that self-renew and exhibit tumorigenicity. It remains unclear whether tumorigenicity exists as a static property of a few cells or as a dynamically acquired property. We used ...

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Human anti-nucleolin recombinant immunoagent for cancer therapy [Medical Sciences]

28-Jul-2015 | Dario Palmieri; Timothy Richmond; Claudia Piovan; Tyler Sheetz; Nicola Zanesi; Fulvia Troise; Cindy James; Dorothee ..., Proceedings of the National Academy of Sciences current issue, 2015

Nucleolin (NCL) is a nucleocytoplasmic protein involved in many biological processes, such as ribosomal assembly, rRNA processing, and mRNA stabilization. NCL also regulates the biogenesis of specific microRNAs (miRNAs) involved in tumor development and aggressiveness. Interestingly, NCL is ...

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EGFR inhibition evokes innate drug resistance in lung cancer cells by preventing Akt activity and thus inactivating Ets-1 function [Cell Biology]

21-Jul-2015 | Janyaporn Phuchareon; Frank McCormick; David W. Eisele; Osamu Tetsu, Proceedings of the National Academy of Sciences current issue, 2015

Nonsmall cell lung cancer (NSCLC) is the leading cause of cancer death worldwide. About 14% of NSCLCs harbor mutations in epidermal growth factor receptor (EGFR). Despite remarkable progress in treatment with tyrosine kinase inhibitors (TKIs), only 5% of patients achieve tumor reduction >90%. The ...

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