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504 Newest Publications in proceedings of the national academy of sciences current issue

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Reply to Leithner et al.: Focus on phopshoenolpyruvate carboxykinase (PEPCK): A target of the p53-SIRT6-FoxO1 axis [Biological Sciences]

21-10-2014 | Zhiming Li; Wei-Guo Zhu, Proceedings of the National Academy of Sciences current issue, 2014

Cancer metabolism has drawn widespread attention since the unique metabolic properties of cancer cells were characterized. We found that p53, a potent tumor suppressor, down-regulates the expression of phopshoenolpyruvate carboxykinase (PEPCK, PCK1) in coordination with histone deacetylase ...

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Label-free electrochemical detection of human methyltransferase from tumors [Biochemistry]

21-10-2014 | Ariel L. Furst; Natalie B. Muren; Michael G. Hill; Jacqueline K. Barton, Proceedings of the National Academy of Sciences current issue, 2014

The role of abnormal DNA methyltransferase activity in the development and progression of cancer is an essential and rapidly growing area of research, both for improved diagnosis and treatment. However, current technologies for the assessment of methyltransferase activity, particularly from crude ...

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Gluconeogenesis in cancer: Door wide open [Biological Sciences]

21-10-2014 | Katharina Leithner; Andelko Hrzenjak; Horst Olschewski, Proceedings of the National Academy of Sciences current issue, 2014

Zhang et al. (1) make a valuable contribution to the field of cancer metabolism, showing that the tumor suppressor p53 down-regulates the gluconeogenic key enzyme phosphoenolpyruvate carboxykinase (PEPCK, PCK1) via histone deacetylase sirtuin 6. The authors conclude that inhibition of ...

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KAISO, a critical regulator of p53-mediated transcription of CDKN1A and apoptotic genes [Biochemistry]

21-10-2014 | Dong-In Koh; Dohyun Han; Hoon Ryu; Won-Il Choi; Bu-Nam Jeon; Min-Kyeong Kim; Youngsoo Kim; Jin Young Kim; Lee Parry; ..., Proceedings of the National Academy of Sciences current issue, 2014

An unresolved issue in genotoxic stress response is identification of induced regulatory proteins and how these activate tumor suppressor p53 to determine appropriate cell responses. Transcription factor KAISO was previously described to repress transcription following binding to methylated DNA. ...

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Seriniquinone, a selective anticancer agent, induces cell death by autophagocytosis, targeting the cancer-protective protein dermcidin [Pharmacology]

14-10-2014 | Lynnie Trzoss; Takashi Fukuda; Letícia V. Costa-Lotufo; Paula Jimenez; James J. La Clair; William Fenical, Proceedings of the National Academy of Sciences current issue, 2014

Natural products continue to provide vital treatment options for cancer. Although their translation into chemotherapeutics is complex, collaborative programs continue to deliver productive pipelines for cancer chemotherapy. A new natural product, seriniquinone, isolated from a marine bacterium of ...

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Modeling tumor heterogeneity and predicting effective combined therapies through computational optimization algorithms [Biological Sciences]

14-10-2014 | Francisco J. Azuaje, Proceedings of the National Academy of Sciences current issue, 2014

Zhao et al. (1) report a computational method that models intratumor heterogeneity and its responses to drug combinations. The authors computationally simulated intratumor heterogeneity by mixing samples derived from a large collection of lymphoma cells, which were previously infected with ...

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ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers [Cell Biology]

14-10-2014 | Alexander Augustyn; Mark Borromeo; Tao Wang; Junya Fujimoto; Chunli Shao; Patrick D. Dospoy; Victoria Lee; Christoph ..., Proceedings of the National Academy of Sciences current issue, 2014

Aggressive neuroendocrine lung cancers, including small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC), represent an understudied tumor subset that accounts for approximately 40,000 new lung cancer cases per year in the United States. No targeted therapy exists for these tumors. ...

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Human DNA tumor viruses generate alternative reading frame proteins through repeat sequence recoding [Microbiology]

14-10-2014 | Hyun Jin Kwun; Tuna Toptan; Suzane Ramos da Silva; John F. Atkins; Patrick S. Moore; Yuan Chang, Proceedings of the National Academy of Sciences current issue, 2014

Kaposi’s sarcoma-associated herpesvirus (KSHV) and Epstein–Barr virus (EBV) are human DNA tumor viruses that express nuclear antigens [latency-associated nuclear antigen 1 (LANA1) and Epstein–Barr nuclear antigen 1 (EBNA1)] necessary to maintain and replicate the viral genome. We report here that ...

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A 3D matrix platform for the rapid generation of therapeutic anti-human carcinoma monoclonal antibodies [Medical Sciences]

14-10-2014 | David T. Dudley; Xiao-Yan Li; Casey Y. Hu; Celina G. Kleer; Amanda L. Willis; Stephen J. Weiss, Proceedings of the National Academy of Sciences current issue, 2014

Efforts to develop unbiased screens for identifying novel function-blocking monoclonal antibodies (mAbs) in human carcinomatous states have been hampered by the limited ability to design in vitro models that recapitulate tumor cell behavior in vivo. Given that only invasive carcinoma cells gain ...

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Modeling putative therapeutic implications of exosome exchange between tumor and immune cells [Biophysics and Computational Biology]

07-10-2014 | Mingyang Lu; Bin Huang; Samir M. Hanash; José N. Onuchic; Eshel Ben-Jacob, Proceedings of the National Academy of Sciences current issue, 2014

Development of effective strategies to mobilize the immune system as a therapeutic modality in cancer necessitates a better understanding of the contribution of the tumor microenvironment to the complex interplay between cancer cells and the immune response. Recently, effort has been directed at ...

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