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16,614 Newest Publications in proceedings of the national academy of sciences current issue

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Absolute position total internal reflection microscopy with an optical tweezer [Applied Physical Sciences]

30-Dec-2014 | Lulu Liu; Alexander Woolf; Alejandro W. Rodriguez; Federico Capasso, Proceedings of the National Academy of Sciences current issue, 2014

A noninvasive, in situ calibration method for total internal reflection microscopy (TIRM) based on optical tweezing is presented, which greatly expands the capabilities of this technique. We show that by making only simple modifications to the basic TIRM sensing setup and procedure, a probe ...

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Correction for Miao et al., Motionless phase stepping in X-ray phase contrast imaging with a compact source [Correction]

30-Dec-2014 | Proceedings of the National Academy of Sciences current issue, 2014

APPLIED PHYSICAL SCIENCES Correction for “Motionless phase stepping in X-ray phase contrast imaging with a compact source,” by Houxun Miao, Lei Chen, Eric E. Bennett, Nick M. Adamo, Andrew A. Gomella, Alexa M. DeLuca, Ajay Patel, Nicole Y. Morgan, and Han Wen, which appeared in issue 48, November ...

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Wolbachia small noncoding RNAs and their role in cross-kingdom communications [Microbiology]

30-Dec-2014 | Jaime G. Mayoral; Mazhar Hussain; D. Albert Joubert; Iñaki Iturbe-Ormaetxe; Scott L. O’Neill; Sassan Asgari, Proceedings of the National Academy of Sciences current issue, 2014

In prokaryotes, small noncoding RNAs (snRNAs) of 50–500 nt are produced that are important in bacterial virulence and response to environmental stimuli. Here, we identified and characterized snRNAs from the endosymbiotic bacteria, Wolbachia, which are widespread in invertebrates and cause ...

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In vivo anticancer activity of rhomboidal Pt(II) metallacycles [Chemistry]

30-Dec-2014 | Ivan V. Grishagin; J. Bryant Pollock; Swati Kushal; Timothy R. Cook; Peter J. Stang; Bogdan Z. Olenyuk, Proceedings of the National Academy of Sciences current issue, 2014

The development of novel antitumor agents that have high efficacy in suppressing tumor growth, have low toxicity to nontumor tissues, and exhibit rapid localization in the targeted tumor sites is an ongoing avenue of research at the interface of chemistry, cancer biology, and pharmacology. ...

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The role of self-interest in elite bargaining [Political Sciences]

30-Dec-2014 | Brad L. LeVeck; D. Alex Hughes; James H. Fowler; Emilie Hafner-Burton; David G. Victor, Proceedings of the National Academy of Sciences current issue, 2014

One of the best-known and most replicated laboratory results in behavioral economics is that bargainers frequently reject low offers, even when it harms their material self-interest. This finding could have important implications for international negotiations on many problems facing humanity ...

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Reply to Abatzoglou et al.: Atmospheric controls on northwest United States air temperatures, 1948-2012 [Physical Sciences]

30-Dec-2014 | James A. Johnstone; Nathan J. Mantua, Proceedings of the National Academy of Sciences current issue, 2014

We recently documented a strong relationship between northeast Pacific sea-level pressure (SLP) and coastal North American sea surface temperature (SSTs) and surface air temperatures (SATs), concluding that atmospheric circulation changes produced nearly all observed coastal warming from 1900 to ...

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Expression and prognostic impact of lncRNAs in acute myeloid leukemia [Medical Sciences]

30-Dec-2014 | Ramiro Garzon; Stefano Volinia; Dimitrios Papaioannou; Deedra Nicolet; Jessica Kohlschmidt; Pearlly S. Yan; Krzyszto ..., Proceedings of the National Academy of Sciences current issue, 2014

Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides, located within the intergenic stretches or overlapping antisense transcripts of protein coding genes. LncRNAs are involved in numerous biological roles including imprinting, epigenetic regulation, apoptosis, and cell ...

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Structural basis of HIV-1 capsid recognition by PF74 and CPSF6 [Biophysics and Computational Biology]

30-Dec-2014 | Akash Bhattacharya; Steven L. Alam; Thomas Fricke; Kaneil Zadrozny; Jaroslaw Sedzicki; Alexander B. Taylor; Borries ..., Proceedings of the National Academy of Sciences current issue, 2014

Upon infection of susceptible cells by HIV-1, the conical capsid formed by ∼250 hexamers and 12 pentamers of the CA protein is delivered to the cytoplasm. The capsid shields the RNA genome and proteins required for reverse transcription. In addition, the surface of the capsid mediates numerous ...

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Hedgehog-induced phosphorylation by CK1 sustains the activity of Ci/Gli activator [Developmental Biology]

30-Dec-2014 | Qing Shi; Shuang Li; Shuangxi Li; Alice Jiang; Yongbin Chen; Jin Jiang, Proceedings of the National Academy of Sciences current issue, 2014

Hedgehog (Hh) signaling governs many developmental processes by regulating the balance between the repressor (CiR/GliR) and activator (CiA/GliA) forms of Cubitus interruptus (Ci)/glioma-associated oncogene homolog (Gli) transcription factors. Although much is known about how CiR/GliR is ...

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Bifurcation analysis of single-cell gene expression data reveals epigenetic landscape [Biophysics and Computational Biology]

30-Dec-2014 | Eugenio Marco; Robert L. Karp; Guoji Guo; Paul Robson; Adam H. Hart; Lorenzo Trippa; Guo-Cheng Yuan, Proceedings of the National Academy of Sciences current issue, 2014

We present single-cell clustering using bifurcation analysis (SCUBA), a novel computational method for extracting lineage relationships from single-cell gene expression data and modeling the dynamic changes associated with cell differentiation. SCUBA draws techniques from nonlinear dynamics and ...

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