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11,227 Newest Publications in proceedings of the national academy of sciences current issue
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HMGA2/TET1/HOXA9 signaling pathway regulates breast cancer growth and metastasis [Medical Sciences]
11-06-2013 | Miao Sun; Chun-Xiao Song; Hao Huang; Casey A. Frankenberger; Devipriya Sankarasharma; Suzana Gomes; Ping Chen; Jianj ..., Proceedings of the National Academy of Sciences current issue, 2013
The ten–eleven translocation (TET) family of methylcytosine dioxygenases initiates demethylation of DNA and is associated with tumorigenesis in many cancers; however, the mechanism is mostly unknown. Here we identify upstream activators and downstream effectors of TET1 in breast cancer using ...
Climbing, falling, and jamming during ant locomotion in confined environments [Applied Physical Sciences]
11-06-2013 | Nick Gravish; Daria Monaenkova; Michael A. D. Goodisman; Daniel I. Goldman, Proceedings of the National Academy of Sciences current issue, 2013
Locomotion emerges from effective interactions of an individual with its environment. Principles of biological terrestrial locomotion have been discovered on unconfined vertical and horizontal substrates. However, a diversity of organisms construct, inhabit, and move within confined spaces. ...
Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer [Immunology]
11-06-2013 | Bo Hu; Eran Elinav; Samuel Huber; Till Strowig; Liming Hao; Anja Hafemann; Chengcheng Jin; Stephanie C. Eisenbarth; ..., Proceedings of the National Academy of Sciences current issue, 2013
The microbiota is pivotal in the pathogenesis of inflammatory bowel disease (IBD)-associated inflammation-induced colorectal cancer (CRC), yet mechanisms for these effects remain poorly characterized. Here, we demonstrate that aberrant inflammasome-induced microbiota plays a critical role in ...
Regulated ADAM17-dependent EGF family ligand release by substrate-selecting signaling pathways [Cell Biology]
11-06-2013 | Michelle Dang; Nicole Armbruster; Miles A. Miller; Efrain Cermeno; Monika Hartmann; George W. Bell; David E. Root; D ..., Proceedings of the National Academy of Sciences current issue, 2013
Ectodomain cleavage of cell-surface proteins by A disintegrin and metalloproteinases (ADAMs) is highly regulated, and its dysregulation has been linked to many diseases. ADAM10 and ADAM17 cleave most disease-relevant substrates. Broad-spectrum metalloprotease inhibitors have failed ...
Circadian clock regulates the host response to Salmonella [Medical Sciences]
11-06-2013 | Marina M. Bellet; Elisa Deriu; Janet Z. Liu; Benedetto Grimaldi; Christoph Blaschitz; Michael Zeller; Robert A. Edwa ..., Proceedings of the National Academy of Sciences current issue, 2013
Organisms adapt to day–night cycles through highly specialized circadian machinery, whose molecular components anticipate and drive changes in organism behavior and metabolism. Although many effectors of the immune system are known to follow daily oscillations, the role of the circadian clock ...
Translation initiation factor eIF3h targets specific transcripts to polysomes during embryogenesis [Developmental Biology]
11-06-2013 | Avik Choudhuri; Umadas Maitra; Todd Evans, Proceedings of the National Academy of Sciences current issue, 2013
Eukaryotic translation initiation factor 3 (eIF3) plays a central role in translation initiation and consists of five core (conserved) subunits present in both budding yeast and higher eukaryotes. Higher eukaryotic eIF3 contains additional (noncore or nonconserved) subunits of poorly defined ...
Mosaic genome structure of the barley powdery mildew pathogen and conservation of transcriptional programs in divergent hosts [Microbiology]
11-06-2013 | Stéphane Hacquard; Barbara Kracher; Takaki Maekawa; Saskia Vernaldi; Paul Schulze-Lefert; Emiel Ver Loren van Themaat, Proceedings of the National Academy of Sciences current issue, 2013
Barley powdery mildew, Blumeria graminis f. sp. hordei (Bgh), is an obligate biotrophic ascomycete fungal pathogen that can grow and reproduce only on living cells of wild or domesticated barley (Hordeum sp.). Domestication and deployment of resistant barley cultivars by humans selected for ...
General mechanism for modulating immunoglobulin effector function [Immunology]
11-06-2013 | Peter Sondermann; Andrew Pincetic; Jad Maamary; Katja Lammens; Jeffrey V. Ravetch, Proceedings of the National Academy of Sciences current issue, 2013
Immunoglobulins recognize and clear microbial pathogens and toxins through the coupling of variable region specificity to Fc-triggered cellular activation. These proinflammatory activities are regulated, thus avoiding the pathogenic sequelae of uncontrolled inflammation by modulating the ...
Sodium/hydrogen exchanger NHA2 is critical for insulin secretion in {beta}-cells [Physiology]
11-06-2013 | Christine Deisl; Alexandre Simonin; Manuel Anderegg; Giuseppe Albano; Gergely Kovacs; Daniel Ackermann; Holger Moch; ..., Proceedings of the National Academy of Sciences current issue, 2013
NHA2 is a sodium/hydrogen exchanger with unknown physiological function. Here we show that NHA2 is present in rodent and human β-cells, as well as β-cell lines. In vivo, two different strains of NHA2-deficient mice displayed a pathological glucose tolerance with impaired insulin secretion but ...
Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain {alpha}-ketoacid dehydrogenase kinase [Biochemistry]
11-06-2013 | Shih-Chia Tso; Xiangbing Qi; Wen-Jun Gui; Jacinta L. Chuang; Lorraine K. Morlock; Amy L. Wallace; Kamran Ahmed; Suni ..., Proceedings of the National Academy of Sciences current issue, 2013
The branched-chain amino acids (BCAAs) leucine, isoleucine, and valine are elevated in maple syrup urine disease, heart failure, obesity, and type 2 diabetes. BCAA homeostasis is controlled by the mitochondrial branched-chain α-ketoacid dehydrogenase complex (BCKDC), which is negatively ...
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