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22,596 Newest Publications in proceedings of the national academy of sciences current issue

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Reply to Walker and Stickgold: Proposed boundary conditions on memory reconsolidation will require empirical verification [Social Sciences]

12-Jul-2016 | Tom E. Hardwicke; David R. Shanks, Proceedings of the National Academy of Sciences current issue, 2016

Broadly speaking, nonreplications of the kind we reported (1) can occur for three reasons: (i) the original finding was a false-positive, (ii) the replication was a false-negative, or (iii) some unanticipated variable moderated the effect. The authors of the original study, Walker and Stickgold ...

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Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice [Developmental Biology]

12-Jul-2016 | Haruhiko Miyata; Julio M. Castaneda; Yoshitaka Fujihara; Zhifeng Yu; Denise R. Archambeault; Ayako Isotani; Daiji Ki ..., Proceedings of the National Academy of Sciences current issue, 2016

Gene-expression analysis studies from Schultz et al. estimate that more than 2,300 genes in the mouse genome are expressed predominantly in the male germ line. As of their 2003 publication [Schultz N, Hamra FK, Garbers DL (2003) Proc Natl Acad Sci USA 100(21):12201–12206], the functions of the ...

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When genes and environment disagree: Making sense of trends in recent human evolution [Social Sciences]

12-Jul-2016 | Alexandre Courtiol; Felix C. Tropf; Melinda C. Mills, Proceedings of the National Academy of Sciences current issue, 2016

In humans, for the first time, we are now able to observe ongoing natural selection at the molecular level. Natural selection operates when particular genetic variants render the individuals who bear them more likely to reproduce. As a consequence, those genetic variants increase in frequency in ...

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Phospholipase C{beta}1 induces membrane tubulation and is involved in caveolae formation [Cell Biology]

12-Jul-2016 | Takehiko Inaba; Takuma Kishimoto; Motohide Murate; Takuya Tajima; Shota Sakai; Mitsuhiro Abe; Asami Makino; Nario To ..., Proceedings of the National Academy of Sciences current issue, 2016

Lipid membrane curvature plays important roles in various physiological phenomena. Curvature-regulated dynamic membrane remodeling is achieved by the interaction between lipids and proteins. So far, several membrane sensing/sculpting proteins, such as Bin/amphiphysin/Rvs (BAR) proteins, are ...

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FtsK translocation permits discrimination between an endogenous and an imported Xer/dif recombination complex [Microbiology]

12-Jul-2016 | Florian Fournes; Estelles Crozat; Carine Pages; Catherine Tardin; Laurence Salomé; François Cornet; Philippe Rousseau, Proceedings of the National Academy of Sciences current issue, 2016

In bacteria, the FtsK/Xer/dif (chromosome dimer resolution site) system is essential for faithful vertical genetic transmission, ensuring the resolution of chromosome dimers during their segregation to daughter cells. This system is also targeted by mobile genetic elements that integrate into ...

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Bacterial lipids activate, synergize, and inhibit a developmental switch in choanoflagellates [Microbiology]

12-Jul-2016 | Arielle Woznica; Alexandra M. Cantley; Christine Beemelmanns; Elizaveta Freinkman; Jon Clardy; Nicole King, Proceedings of the National Academy of Sciences current issue, 2016

In choanoflagellates, the closest living relatives of animals, multicellular rosette development is regulated by environmental bacteria. The simplicity of this evolutionarily relevant interaction provides an opportunity to identify the molecules and regulatory logic underpinning bacterial ...

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Holsteins are the genomic selection poster cows [Agricultural Sciences]

12-Jul-2016 | Jeremy F. Taylor; Kristen H. Taylor; Jared E. Decker, Proceedings of the National Academy of Sciences current issue, 2016

Genomic selection (GS) is the process by which the genetic improvement of plants or animals is accomplished using the genomic prediction (GP) of additive genetic merits [known as genomic estimated breeding values (GEBVs)] of selection candidates. Alternative statistical models for GP were first ...

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Macronutrient ratios in pollen shape bumble bee (Bombus impatiens) foraging strategies and floral preferences [Ecology]

12-Jul-2016 | Anthony D. Vaudo; Harland M. Patch; David A. Mortensen; John F. Tooker; Christina M. Grozinger, Proceedings of the National Academy of Sciences current issue, 2016

To fuel their activities and rear their offspring, foraging bees must obtain a sufficient quality and quantity of nutritional resources from a diverse plant community. Pollen is the primary source of proteins and lipids for bees, and the concentrations of these nutrients in pollen can vary widely ...

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GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes [Immunology and Inflammation]

12-Jul-2016 | Robin A. Aglietti; Alberto Estevez; Aaron Gupta; Monica Gonzalez Ramirez; Peter S. Liu; Nobuhiko Kayagaki; Claudio C ..., Proceedings of the National Academy of Sciences current issue, 2016

Gasdermin-D (GsdmD) is a critical mediator of innate immune defense because its cleavage by the inflammatory caspases 1, 4, 5, and 11 yields an N-terminal p30 fragment that induces pyroptosis, a death program important for the elimination of intracellular bacteria. Precisely how GsdmD p30 ...

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Theranostic near-infrared fluorescent nanoplatform for imaging and systemic siRNA delivery to metastatic anaplastic thyroid cancer [Medical Sciences]

12-Jul-2016 | Yanlan Liu; Viswanath Gunda; Xi Zhu; Xiaoding Xu; Jun Wu; Diana Askhatova; Omid C. Farokhzad; Sareh Parangi; Jinjun Shi, Proceedings of the National Academy of Sciences current issue, 2016

Anaplastic thyroid cancer (ATC), one of the most aggressive solid tumors, is characterized by rapid tumor growth and severe metastasis to other organs. Owing to the lack of effective treatment options, ATC has a mortality rate of ∼100% and median survival of less than 5 months. RNAi ...

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