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25,358 Newest Publications in proceedings of the national academy of sciences current issue

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Communicating the deadly consequences of global warming for human heat stress [Environmental Sciences]

11-Apr-2017 | Tom K. R. Matthews; Robert L. Wilby; Conor Murphy, Proceedings of the National Academy of Sciences current issue, 2017

In December of 2015, the international community pledged to limit global warming to below 2 °C above preindustrial (PI) to prevent dangerous climate change. However, to what extent, and for whom, is danger avoided if this ambitious target is realized? We address these questions by scrutinizing ...

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Form and function of topologically associating genomic domains in budding yeast [Cell Biology]

11-Apr-2017 | Umut Eser; Devon Chandler-Brown; Ferhat Ay; Aaron F. Straight; Zhijun Duan; William Stafford Noble; Jan M. Skotheim, Proceedings of the National Academy of Sciences current issue, 2017

The genome of metazoan cells is organized into topologically associating domains (TADs) that have similar histone modifications, transcription level, and DNA replication timing. Although similar structures appear to be conserved in fission yeast, computational modeling and analysis of ...

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Pore translocation of knotted DNA rings [Biophysics and Computational Biology]

11-Apr-2017 | Antonio Suma; Cristian Micheletti, Proceedings of the National Academy of Sciences current issue, 2017

We use an accurate coarse-grained model for DNA and stochastic molecular dynamics simulations to study the pore translocation of 10-kbp–long DNA rings that are knotted. By monitoring various topological and physical observables we find that there is not one, as previously assumed, but rather two ...

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Structural reconstruction of protein ancestry [Biophysics and Computational Biology]

11-Apr-2017 | Romain Rouet; David B. Langley; Peter Schofield; Mary Christie; Brendan Roome; Benjamin T. Porebski; Ashley M. Buckl ..., Proceedings of the National Academy of Sciences current issue, 2017

Ancestral protein reconstruction allows the resurrection and characterization of ancient proteins based on computational analyses of sequences of modern-day proteins. Unfortunately, many protein families are highly divergent and not suitable for sequence-based reconstruction approaches. This ...

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Quantification of circulating Mycobacterium tuberculosis antigen peptides allows rapid diagnosis of active disease and treatment monitoring [Engineering]

11-Apr-2017 | Chang Liu; Zhen Zhao; Jia Fan; Christopher J. Lyon; Hung-Jen Wu; Dobrin Nedelkov; Adrian M. Zelazny; Kenneth N. Oliv ..., Proceedings of the National Academy of Sciences current issue, 2017

Tuberculosis (TB) is a major global health threat, resulting in an urgent unmet need for a rapid, non–sputum-based quantitative test to detect active Mycobacterium tuberculosis (Mtb) infections in clinically diverse populations and quickly assess Mtb treatment responses for emerging ...

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Ancient palace complex (300-100 BC) discovered in the Valley of Oaxaca, Mexico [Anthropology]

11-Apr-2017 | Elsa M. Redmond; Charles S. Spencer, Proceedings of the National Academy of Sciences current issue, 2017

Recently completed excavations at the site of El Palenque in Mexico’s Valley of Oaxaca have recovered the well-preserved remains of a palace complex dated by associated radiocarbon samples and ceramics to the Late Formative period or Late Monte Albán I phase (300–100 BC), the period of archaic ...

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Comparing nonpharmaceutical interventions for containing emerging epidemics [Population Biology]

11-Apr-2017 | Corey M. Peak; Lauren M. Childs; Yonatan H. Grad; Caroline O. Buckee, Proceedings of the National Academy of Sciences current issue, 2017

Strategies for containing an emerging infectious disease outbreak must be nonpharmaceutical when drugs or vaccines for the pathogen do not yet exist or are unavailable. The success of these nonpharmaceutical strategies will depend on not only the effectiveness of isolation measures but also the ...

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Metabolic evolution and the self-organization of ecosystems [Evolution]

11-Apr-2017 | Rogier Braakman; Michael J. Follows; Sallie W. Chisholm, Proceedings of the National Academy of Sciences current issue, 2017

Metabolism mediates the flow of matter and energy through the biosphere. We examined how metabolic evolution shapes ecosystems by reconstructing it in the globally abundant oceanic phytoplankter Prochlorococcus. To understand what drove observed evolutionary patterns, we interpreted them in the ...

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Transfer of pathogenic and nonpathogenic cytosolic proteins between spinal cord motor neurons in vivo in chimeric mice [Neuroscience]

11-Apr-2017 | Eleanor V. Thomas; Wayne A. Fenton; James McGrath; Arthur L. Horwich, Proceedings of the National Academy of Sciences current issue, 2017

Recent studies have reported spread of pathogenic proteins in the mammalian nervous system, but whether nonpathogenic ones spread is unknown. We initially investigated whether spread of a mutant amyotrophic lateral sclerosis-associated cytosolic superoxide dismutase 1 (SOD1) protein between motor ...

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Effectiveness of UNAIDS targets and HIV vaccination across 127 countries [Population Biology]

11-Apr-2017 | Jan Medlock; Abhishek Pandey; Alyssa S. Parpia; Amber Tang; Laura A. Skrip; Alison P. Galvani, Proceedings of the National Academy of Sciences current issue, 2017

The HIV pandemic continues to impose enormous morbidity, mortality, and economic burdens across the globe. Simultaneously, innovations in antiretroviral therapy, diagnostic approaches, and vaccine development are providing novel tools for treatment-as-prevention and prophylaxis. We developed a ...

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