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21,800 Newest Publications in proceedings of the national academy of sciences current issue

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Correction for Springer and Sen, Leukocyte integrin {alpha}L{beta}2 headpiece structures: The {alpha}I domain, the pocket for the internal ligand, and concerted movements of its loops [Correction]

19-Apr-2016 | Proceedings of the National Academy of Sciences current issue, 2016

BIOPHYSICS AND COMPUTATIONAL BIOLOGY Correction for “Leukocyte integrin αLβ2 headpiece structures: The αI domain, the pocket for the internal ligand, and concerted movements of its loops,” by Timothy A. Springer and Mehmet Sen, which appeared in issue 11, March 15, 2016, of Proc Natl Acad Sci USA ...

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Inflammatory and neuropathic cold allodynia are selectively mediated by the neurotrophic factor receptor GFR{alpha}3 [Neuroscience]

19-Apr-2016 | Erika K. Lippoldt; Serra Ongun; Geoffrey K. Kusaka; David D. McKemy, Proceedings of the National Academy of Sciences current issue, 2016

Tissue injury prompts the release of a number of proalgesic molecules that induce acute and chronic pain by sensitizing pain-sensing neurons (nociceptors) to heat and mechanical stimuli. In contrast, many proalgesics have no effect on cold sensitivity or can inhibit cold-sensitive neurons and ...

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Molecular basis for universal HLA-A*0201-restricted CD8+ T-cell immunity against influenza viruses [Immunology and Inflammation]

19-Apr-2016 | Sophie A. Valkenburg; Tracy M. Josephs; E. Bridie Clemens; Emma J. Grant; Thi H. O. Nguyen; George C. Wang; David A. ..., Proceedings of the National Academy of Sciences current issue, 2016

Memory CD8+ T lymphocytes (CTLs) specific for antigenic peptides derived from internal viral proteins confer broad protection against distinct strains of influenza A virus (IAV). However, immune efficacy can be undermined by the emergence of escape mutants. To determine how T-cell receptor (TCR) ...

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Hall effect in quantum critical charge-cluster glass [Physics]

19-Apr-2016 | Jie Wu; Anthony T. Bollinger; Yujie Sun; Ivan Božović, Proceedings of the National Academy of Sciences current issue, 2016

Upon doping, cuprates undergo a quantum phase transition from an insulator to a d-wave superconductor. The nature of this transition and of the insulating state is vividly debated. Here, we study the Hall effect in La2-xSrxCuO4 (LSCO) samples doped near the quantum critical point at x ∼ 0.06. ...

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Individual differences in frontolimbic circuitry and anxiety emerge with adolescent changes in endocannabinoid signaling across species [Psychological and Cognitive Sciences]

19-Apr-2016 | Dylan G. Gee; Robert N. Fetcho; Deqiang Jing; Anfei Li; Charles E. Glatt; Andrew T. Drysdale; Alexandra O. Cohen; Da ..., Proceedings of the National Academy of Sciences current issue, 2016

Anxiety disorders peak in incidence during adolescence, a developmental window that is marked by dynamic changes in gene expression, endocannabinoid signaling, and frontolimbic circuitry. We tested whether genetic alterations in endocannabinoid signaling related to a common polymorphism in fatty ...

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Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival [Medical Sciences]

19-Apr-2016 | Jonas Kloepper; Lars Riedemann; Zohreh Amoozgar; Giorgio Seano; Katharina Susek; Veronica Yu; Nisha Dalvie; Robin L. ..., Proceedings of the National Academy of Sciences current issue, 2016

Inhibition of the vascular endothelial growth factor (VEGF) pathway has failed to improve overall survival of patients with glioblastoma (GBM). We previously showed that angiopoietin-2 (Ang-2) overexpression compromised the benefit from anti-VEGF therapy in a preclinical GBM model. Here we ...

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Surface force measurements and simulations of mussel-derived peptide adhesives on wet organic surfaces [Biophysics and Computational Biology]

19-Apr-2016 | Zachary A. Levine; Michael V. Rapp; Wei Wei; Ryan Gotchy Mullen; Chun Wu; Gül H. Zerze; Jeetain Mittal; J. Herbert W ..., Proceedings of the National Academy of Sciences current issue, 2016

Translating sticky biological molecules—such as mussel foot proteins (MFPs)—into synthetic, cost-effective underwater adhesives with adjustable nano- and macroscale characteristics requires an intimate understanding of the glue’s molecular interactions. To help facilitate the next generation of ...

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HERV-K HML-2 diversity among humans [Microbiology]

19-Apr-2016 | Jack Lenz, Proceedings of the National Academy of Sciences current issue, 2016

Retroviruses comprise over 8% of the human genome (1, 2). Human endogenous retroviruses (HERVs) exist as DNA remnants of infections that occurred in germ lineage cells of our ancestors. Most of this viral DNA is mutated, often including various large disruptions, but some components are intact or ...

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Correction for Lee et al., Shox2 is a molecular determinant of depot-specific adipocyte function [Correction]

19-Apr-2016 | Proceedings of the National Academy of Sciences current issue, 2016

CELL BIOLOGY Correction for “Shox2 is a molecular determinant of depot-specific adipocyte function,” by Kevin Y. Lee, Yuji Yamamoto, Jeremie Boucher, Jonathon N. Winnay, Stephane Gesta, John Cobb, Matthias Blüher, and C. Ronald Kahn, which appeared in issue 28, July 9, 2013, of Proc Natl Acad Sci ...

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Stability-driven nonnegative matrix factorization to interpret spatial gene expression and build local gene networks [Systems Biology]

19-Apr-2016 | Siqi Wu; Antony Joseph; Ann S. Hammonds; Susan E. Celniker; Bin Yu; Erwin Frise, Proceedings of the National Academy of Sciences current issue, 2016

Spatial gene expression patterns enable the detection of local covariability and are extremely useful for identifying local gene interactions during normal development. The abundance of spatial expression data in recent years has led to the modeling and analysis of regulatory networks. The ...

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