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27,239 Newest Publications in proceedings of the national academy of sciences current issue

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Entropy and optimality in river deltas [Earth, Atmospheric, and Planetary Sciences]

31-Oct-2017 | Alejandro Tejedor; Anthony Longjas; Douglas A. Edmonds; Ilya Zaliapin; Tryphon T. Georgiou; Andrea Rinaldo; Efi Fouf ..., Proceedings of the National Academy of Sciences current issue, 2017

The form and function of river deltas is intricately linked to the evolving structure of their channel networks, which controls how effectively deltas are nourished with sediments and nutrients. Understanding the coevolution of deltaic channels and their flux organization is crucial for guiding ...

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Early rearing history influences oxytocin receptor epigenetic regulation in rhesus macaques [Neuroscience]

31-Oct-2017 | Maggie Baker; Stephen G. Lindell; Carlos A. Driscoll; Zhifeng Zhou; Qiaoping Yuan; Melanie L. Schwandt; Isaac Miller ..., Proceedings of the National Academy of Sciences current issue, 2017

Adaptations to stress can occur through epigenetic processes and may be a conduit for informing offspring of environmental challenge. We employed ChIP-sequencing for H3K4me3 to examine effects of early maternal deprivation (peer-rearing, PR) in archived rhesus macaque hippocampal samples (male, n ...

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TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy [Neuroscience]

24-Oct-2017 | Cheryl E. G. Leyns; Jason D. Ulrich; Mary B. Finn; Floy R. Stewart; Lauren J. Koscal; Javier Remolina Serrano; Grace ..., Proceedings of the National Academy of Sciences current issue, 2017

Variants in the gene encoding the triggering receptor expressed on myeloid cells 2 (TREM2) were recently found to increase the risk for developing Alzheimer’s disease (AD). In the brain, TREM2 is predominately expressed on microglia, and its association with AD adds to increasing evidence ...

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The topography of the environment alters the optimal search strategy for active particles [Physics]

24-Oct-2017 | Giorgio Volpe; Giovanni Volpe, Proceedings of the National Academy of Sciences current issue, 2017

In environments with scarce resources, adopting the right search strategy can make the difference between succeeding and failing, even between life and death. At different scales, this applies to molecular encounters in the cell cytoplasm, to animals looking for food or mates in natural ...

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Rethinking people’s conceptions of mental life [Psychological and Cognitive Sciences]

24-Oct-2017 | Kara Weisman; Carol S. Dweck; Ellen M. Markman, Proceedings of the National Academy of Sciences current issue, 2017

How do people make sense of the emotions, sensations, and cognitive abilities that make up mental life? Pioneering work on the dimensions of mind perception has been interpreted as evidence that people consider mental life to have two core components—experience (e.g., hunger, joy) and agency ...

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Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma [Biochemistry]

24-Oct-2017 | Gregory S. Ducker; Jonathan M. Ghergurovich; Nello Mainolfi; Vipin Suri; Stephanie K. Jeong; Sophia Hsin-Jung Li; Ad ..., Proceedings of the National Academy of Sciences current issue, 2017

The enzyme serine hydroxymethyltransferse (SHMT) converts serine into glycine and a tetrahydrofolate-bound one-carbon unit. Folate one-carbon units support purine and thymidine synthesis, and thus cell growth. Mammals have both cytosolic SHMT1 and mitochondrial SHMT2, with the mitochondrial ...

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Content of mitochondrial calcium uniporter (MCU) in cardiomyocytes is regulated by microRNA-1 in physiologic and pathologic hypertrophy [Cell Biology]

24-Oct-2017 | Tania Zaglia; Paola Ceriotti; Antonio Campo; Giulia Borile; Andrea Armani; Pierluigi Carullo; Valentina Prando; Raff ..., Proceedings of the National Academy of Sciences current issue, 2017

The mitochondrial Ca2+ uniporter complex (MCUC) is a multimeric ion channel which, by tuning Ca2+ influx into the mitochondrial matrix, finely regulates metabolic energy production. In the heart, this dynamic control of mitochondrial Ca2+ uptake is fundamental for cardiomyocytes to adapt to ...

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Opioid and orexin hedonic hotspots in rat orbitofrontal cortex and insula [Neuroscience]

24-Oct-2017 | Daniel C. Castro; Kent C. Berridge, Proceedings of the National Academy of Sciences current issue, 2017

Hedonic hotspots are brain sites where particular neurochemical stimulations causally amplify the hedonic impact of sensory rewards, such as “liking” for sweetness. Here, we report the mapping of two hedonic hotspots in cortex, where mu opioid or orexin stimulations enhance the hedonic impact of ...

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Unique amalgamation of primary and secondary structural elements transform peptaibols into potent bioactive cell-penetrating peptides [Chemistry]

24-Oct-2017 | Lin Du; April L. Risinger; Carter A. Mitchell; Jianlan You; Blake W. Stamps; Ning Pan; Jarrod B. King; Jean C. Bopas ..., Proceedings of the National Academy of Sciences current issue, 2017

Mass-spectrometry-based metabolomics and molecular phylogeny data were used to identify a metabolically prolific strain of Tolypocladium that was obtained from a deep-water Great Lakes sediment sample. An investigation of the isolate’s secondary metabolome resulted in the purification of a 22-mer ...

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Staufen1 inhibits MyoD translation to actively maintain muscle stem cell quiescence [Cell Biology]

24-Oct-2017 | Antoine de Morrée; Cindy T. J. van Velthoven; Qiang Gan; Jayesh S. Salvi; Julian D. D. Klein; Igor Akimenko; Marco Q ..., Proceedings of the National Academy of Sciences current issue, 2017

Tissue regeneration depends on the timely activation of adult stem cells. In skeletal muscle, the adult stem cells maintain a quiescent state and proliferate upon injury. We show that muscle stem cells (MuSCs) use direct translational repression to maintain the quiescent state. High-resolution ...

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