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23,247 Newest Publications in proceedings of the national academy of sciences current issue

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FERONIA interacts with ABI2-type phosphatases to facilitate signaling cross-talk between abscisic acid and RALF peptide in Arabidopsis [Plant Biology]

13-Sep-2016 | Jia Chen; Feng Yu; Ying Liu; Changqing Du; Xiushan Li; Sirui Zhu; Xianchun Wang; Wenzhi Lan; Pedro L. Rodriguez; Xua ..., Proceedings of the National Academy of Sciences current issue, 2016

Receptor-like kinase FERONIA (FER) plays a crucial role in plant response to small molecule hormones [e.g., auxin and abscisic acid (ABA)] and peptide signals [e.g., rapid alkalinization factor (RALF)]. It remains unknown how FER integrates these different signaling events in the control of cell ...

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Dental calculus reveals Mesolithic foragers in the Balkans consumed domesticated plant foods [Anthropology]

13-Sep-2016 | Emanuela Cristiani; Anita Radini; Marija Edinborough; Dušan Borić, Proceedings of the National Academy of Sciences current issue, 2016

Researchers agree that domesticated plants were introduced into southeast Europe from southwest Asia as a part of a Neolithic “package,” which included domesticated animals and artifacts typical of farming communities. It is commonly believed that this package reached inland areas of the Balkans ...

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Communication shapes sensory response in multicellular networks [Physics]

13-Sep-2016 | Garrett D. Potter; Tommy A. Byrd; Andrew Mugler; Bo Sun, Proceedings of the National Academy of Sciences current issue, 2016

Collective sensing by interacting cells is observed in a variety of biological systems, and yet, a quantitative understanding of how sensory information is collectively encoded is lacking. Here, we investigate the ATP-induced calcium dynamics of monolayers of fibroblast cells that communicate via ...

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Cd47-Sirp{alpha} interaction and IL-10 constrain inflammation-induced macrophage phagocytosis of healthy self-cells [Immunology and Inflammation]

13-Sep-2016 | Zhen Bian; Lei Shi; Ya-Lan Guo; Zhiyuan Lv; Cong Tang; Shuo Niu; Alexandra Tremblay; Mahathi Venkataramani; Courtney ..., Proceedings of the National Academy of Sciences current issue, 2016

Rapid clearance of adoptively transferred Cd47-null (Cd47−/−) cells in congeneic WT mice suggests a critical self-recognition mechanism, in which CD47 is the ubiquitous marker of self, and its interaction with macrophage signal regulatory protein α (SIRPα) triggers inhibitory signaling through ...

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Insights into the molecular basis for substrate binding and specificity of the wild-type L-arginine/agmatine antiporter AdiC [Biophysics and Computational Biology]

13-Sep-2016 | Hüseyin Ilgü; Jean-Marc Jeckelmann; Vytautas Gapsys; Zöhre Ucurum; Bert L. de Groot; Dimitrios Fotiadis, Proceedings of the National Academy of Sciences current issue, 2016

Pathogenic enterobacteria need to survive the extreme acidity of the stomach to successfully colonize the human gut. Enteric bacteria circumvent the gastric acid barrier by activating extreme acid-resistance responses, such as the arginine-dependent acid resistance system. In this response, ...

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Histone deacetylase HDA6 enhances brassinosteroid signaling by inhibiting the BIN2 kinase [Plant Biology]

13-Sep-2016 | Yuhan Hao; Haijiao Wang; Shenglong Qiao; Linna Leng; Xuelu Wang, Proceedings of the National Academy of Sciences current issue, 2016

Glycogen synthase kinase 3 (GSK3)-like kinases play important roles in brassinosteroid (BR), abscisic acid, and auxin signaling to regulate many aspects of plant development and stress responses. The Arabidopsis thaliana GSK3-like kinase BR-INSENSITIVE 2 (BIN2) acts as a key negative regulator in ...

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Chemotaxis cluster 1 proteins form cytoplasmic arrays in Vibrio cholerae and are stabilized by a double signaling domain receptor DosM [Microbiology]

13-Sep-2016 | Ariane Briegel; Davi R. Ortega; Petra Mann; Andreas Kjær; Simon Ringgaard; Grant J. Jensen, Proceedings of the National Academy of Sciences current issue, 2016

Nearly all motile bacterial cells use a highly sensitive and adaptable sensory system to detect changes in nutrient concentrations in the environment and guide their movements toward attractants and away from repellents. The best-studied bacterial chemoreceptor arrays are membrane-bound. Many ...

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MYC-nick promotes cell migration by inducing fascin expression and Cdc42 activation [Medical Sciences]

13-Sep-2016 | Sarah Anderson; Kumud Raj Poudel; Minna Roh-Johnson; Thomas Brabletz; Ming Yu; Nofit Borenstein-Auerbach; William N. ..., Proceedings of the National Academy of Sciences current issue, 2016

MYC-nick is a cytoplasmic, transcriptionally inactive member of the MYC oncoprotein family, generated by a proteolytic cleavage of full-length MYC. MYC-nick promotes migration and survival of cells in response to chemotherapeutic agents or withdrawal of glucose. Here we report that MYC-nick is ...

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Buprenorphine analogue BU08028 is one step closer to the Holy Grail of opioid research [Pharmacology]

13-Sep-2016 | Jun-Xu Li, Proceedings of the National Academy of Sciences current issue, 2016

Pain is a major clinical, social, and economic problem, affecting more people than diabetes, heart disease, and cancer combined (1). Pain medicine represents a large family of compounds that are commonly prescribed or sold over-the-counter for treating various painful conditions. Among these ...

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Anatomy of the {beta}-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate [Biochemistry]

13-Sep-2016 | Finn P. Maloney; Lena Gerwick; William H. Gerwick; David H. Sherman; Janet L. Smith, Proceedings of the National Academy of Sciences current issue, 2016

Alkyl branching at the β position of a polyketide intermediate is an important variation on canonical polyketide natural product biosynthesis. The branching enzyme, 3-hydroxy-3-methylglutaryl synthase (HMGS), catalyzes the aldol addition of an acyl donor to a β-keto-polyketide intermediate ...

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