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17,230 Newest Publications in proceedings of the national academy of sciences current issue

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Root surface as a frontier for plant microbiome research [Plant Biology]

24-Feb-2015 | Marcel G. A. van der Heijden; Klaus Schlaeppi, Proceedings of the National Academy of Sciences current issue, 2015

Plants associate—analogous to animals or us humans—with a multitude of microorganisms, which collectively function as a microbiome. A major discovery of the last decade is that numerous organisms of a microbiome (aka microbiota) are not unpretentious background actors. Instead, some microbiota ...

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Glucose-responsive insulin activity by covalent modification with aliphatic phenylboronic acid conjugates [Applied Biological Sciences]

24-Feb-2015 | Danny Hung-Chieh Chou; Matthew J. Webber; Benjamin C. Tang; Amy B. Lin; Lavanya S. Thapa; David Deng; Jonathan V. Tr ..., Proceedings of the National Academy of Sciences current issue, 2015

Since its discovery and isolation, exogenous insulin has dramatically changed the outlook for patients with diabetes. However, even when patients strictly follow an insulin regimen, serious complications can result as patients experience both hyperglycemic and hypoglycemic states. Several ...

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Building coral reef resilience through assisted evolution [Applied Biological Sciences]

24-Feb-2015 | Madeleine J. H. van Oppen; James K. Oliver; Hollie M. Putnam; Ruth D. Gates, Proceedings of the National Academy of Sciences current issue, 2015

The genetic enhancement of wild animals and plants for characteristics that benefit human populations has been practiced for thousands of years, resulting in impressive improvements in commercially valuable species. Despite these benefits, genetic manipulations are rarely considered for ...

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Propagation of aggregated p53: Cross-reaction and coaggregation vs. seeding [Chemistry]

24-Feb-2015 | GuoZhen Wang; Alan R. Fersht, Proceedings of the National Academy of Sciences current issue, 2015

Destabilized mutant p53s coaggregate with WT p53, p63, and p73 in cancer cell lines. We found that stoichiometric amounts of aggregation-prone mutants induced only small amounts of WT p53 to coaggregate, and preformed aggregates did not significantly seed the aggregation of bulk protein. ...

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Perpetual muscle PDH activation in PDH kinase knockout mice protects against high-fat feeding-induced muscle insulin resistance [Biological Sciences]

24-Feb-2015 | Dumitru Constantin-Teodosiu; Francis B. Stephens; Paul L. Greenhaff, Proceedings of the National Academy of Sciences current issue, 2015

Rahimi et al. (1) state that “whether fatty acids induce [muscle] insulin resistance by decreasing PDH [pyruvate dehydrogenase complex] flux remains unknown” and “the role of PDH and mitochondrial oxidative substrate selection in the regulation of basal and insulin-stimulated muscle glucose ...

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Massively expedited genome-wide heritability analysis (MEGHA) [Statistics]

24-Feb-2015 | Tian Ge; Thomas E. Nichols; Phil H. Lee; Avram J. Holmes; Joshua L. Roffman; Randy L. Buckner; Mert R. Sabuncu; Jord ..., Proceedings of the National Academy of Sciences current issue, 2015

The discovery and prioritization of heritable phenotypes is a computational challenge in a variety of settings, including neuroimaging genetics and analyses of the vast phenotypic repositories in electronic health record systems and population-based biobanks. Classical estimates of heritability ...

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Contribution of reactive oxygen species to cerebral amyloid angiopathy, vasomotor dysfunction, and microhemorrhage in aged Tg2576 mice [Neuroscience]

24-Feb-2015 | Byung Hee Han; Meng-liang Zhou; Andrew W. Johnson; Itender Singh; Fan Liao; Ananth K. Vellimana; James W. Nelson; Er ..., Proceedings of the National Academy of Sciences current issue, 2015

Cerebral amyloid angiopathy (CAA) is characterized by deposition of amyloid β peptide (Aβ) within walls of cerebral arteries and is an important cause of intracerebral hemorrhage, ischemic stroke, and cognitive dysfunction in elderly patients with and without Alzheimer’s Disease (AD). NADPH ...

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Penta-graphene: A new carbon allotrope [Physics]

24-Feb-2015 | Shunhong Zhang; Jian Zhou; Qian Wang; Xiaoshuang Chen; Yoshiyuki Kawazoe; Puru Jena, Proceedings of the National Academy of Sciences current issue, 2015

A 2D metastable carbon allotrope, penta-graphene, composed entirely of carbon pentagons and resembling the Cairo pentagonal tiling, is proposed. State-of-the-art theoretical calculations confirm that the new carbon polymorph is not only dynamically and mechanically stable, but also can withstand ...

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Visualizing monolayers with a water-soluble fluorophore to quantify adsorption, desorption, and the double layer [Engineering]

24-Feb-2015 | Ian C. Shieh; Joseph A. Zasadzinski, Proceedings of the National Academy of Sciences current issue, 2015

Contrast in confocal microscopy of phase-separated monolayers at the air–water interface can be generated by the selective adsorption of water-soluble fluorescent dyes to disordered monolayer phases. Optical sectioning minimizes the fluorescence signal from the subphase, whereas convolution of ...

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Elevated intraocular pressure decreases response sensitivity of inner retinal neurons in experimental glaucoma mice [Neuroscience]

24-Feb-2015 | Ji-Jie Pang; Benjamin J. Frankfort; Ronald L. Gross; Samuel M. Wu, Proceedings of the National Academy of Sciences current issue, 2015

Glaucoma is the second leading cause of blindness in the United States and the world, characterized by progressive degeneration of the optic nerve and retinal ganglion cells (RGCs). Glaucoma patients exhibit an early diffuse loss of retinal sensitivity followed by focal loss of RGCs in sectored ...

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