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28,727 Newest Publications in proceedings of the national academy of sciences current issue

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Mesenchymal MAPKAPK2/HSP27 drives intestinal carcinogenesis [Medical Sciences]

12-Jun-2018 | Ana Henriques; Vasiliki Koliaraki; George Kollias, Proceedings of the National Academy of Sciences current issue, 2018

Although MK2 inhibition has been proposed as a therapy in cancer, its exact role, as well as the cellular and molecular mechanisms underlying it, in the intestine is not known. Here, we show that complete MK2 deletion leads to decreased epithelial cell proliferation, associated with reduced tumor ...

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Resolving the ray-finned fish tree of life [Evolution]

12-Jun-2018 | Michael E. Alfaro, Proceedings of the National Academy of Sciences current issue, 2018

When it comes to vertebrate evolutionary history, our understanding of lobe-finned fishes—the branch of the vertebrate tree leading to coelacanths plus the tetrapods (amphibians, turtles, birds, crocodiles, lizards, snakes, and mammals)—far outstrips our knowledge of ray-finned fishes ...

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Dynamic regimes of electrified liquid filaments [Engineering]

12-Jun-2018 | Tiantian Kong; Howard A. Stone; Liqiu Wang; Ho Cheung Shum, Proceedings of the National Academy of Sciences current issue, 2018

A viscous liquid filament subjected to an axial electric field exhibits different behaviors including jetting, coiling, and whipping, which result from the delicate interplay of viscous, electrostatic, and surface tension stresses. Control over these dynamic behaviors of electrified liquid ...

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Activated integrins identify functional antigen-specific CD8+ T cells within minutes after antigen stimulation [Immunology and Inflammation]

12-Jun-2018 | Stoyan Dimitrov; Cécile Gouttefangeas; Luciana Besedovsky; Anja T. R. Jensen; P. Anoop Chandran; Elisa Rusch; Ramona ..., Proceedings of the National Academy of Sciences current issue, 2018

Assessing antigen-specific T cells is crucial for our understanding of immune reactions against pathogens and tumors, and for evaluating immunotherapies in patients. Existing techniques to evaluate the functionality of T lymphocytes all rely on de novo expression of proteins, typically ...

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Electronic cigarette aerosols induce DNA damage and reduce DNA repair: Consistency across species [Biological Sciences]

12-Jun-2018 | Lurdes Queimado; Theodore Wagener; Vengatesh Ganapathy, Proceedings of the National Academy of Sciences current issue, 2018

We read with great interest the work of Lee et al. (1), in which the authors report that mice exposed to electronic cigarette aerosol have increased levels of DNA lesions and decreased DNA repair activity. This work sparked important discussion both in PNAS (2, 3) and science media (4). We do ...

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In This Issue [This Week in PNAS]

12-Jun-2018 | National Academy of Sciences, Proceedings of the National Academy of Sciences current issue, 2018

Dwarf mongooses. Image courtesy of Shannon Wild (photographer). Social animals exchange services, such as grooming, in return for others, such as enabling access to food and mates and warding off rival groups. However, whether nonhuman animals reciprocate based on a memory of recent ...

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Unimolecular reaction of acetone oxide and its reaction with water in the atmosphere [Chemistry]

12-Jun-2018 | Bo Long; Junwei Lucas Bao; Donald G. Truhlar, Proceedings of the National Academy of Sciences current issue, 2018

Obtaining rate constants and tropospheric lifetimes of Criegee intermediates is of critical significance for atmospheric modeling. We report calculations that can produce quantitative rate constants by variational transition state theory with corner-cutting tunneling based on implicit potential ...

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MINFLUX monitors rapid molecular jumps with superior spatiotemporal resolution [Applied Physical Sciences]

12-Jun-2018 | Yvan Eilers; Haisen Ta; Klaus C. Gwosch; Francisco Balzarotti; Stefan W. Hell, Proceedings of the National Academy of Sciences current issue, 2018

Popular localization of single molecules through calculating the centroid of the diffraction pattern produced by molecular fluorescence on a camera is typically limited to spatiotemporal resolutions of >10 nm per >10 milliseconds. By requiring at least 10–100 times fewer detected photons and ...

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Fluctuating radiocarbon offsets observed in the southern Levant and implications for archaeological chronology debates [Anthropology]

12-Jun-2018 | Sturt W. Manning; Carol Griggs; Brita Lorentzen; Christopher Bronk Ramsey; David Chivall; A. J. Timothy Jull; Todd E ..., Proceedings of the National Academy of Sciences current issue, 2018

We observe a substantive and fluctuating offset in measured radiocarbon ages between plant material growing in the southern Levant versus the standard Northern Hemisphere radiocarbon calibration dataset derived from trees growing in central and northern Europe and North America. This likely ...

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Doc2-mediated superpriming supports synaptic augmentation [Neuroscience]

12-Jun-2018 | Renhao Xue; David A. Ruhl; Joseph S. Briguglio; Alexander G. Figueroa; Robert A. Pearce; Edwin R. Chapman, Proceedings of the National Academy of Sciences current issue, 2018

Plastic changes in synaptic connections constitute the basis of learning and memory. Different forms of synaptic plasticity are generally distinguished experimentally by their timescales, but it is unclear whether each form of plasticity corresponds to a distinct biological process with a ...

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