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16,028 Newest Publications in proceedings of the national academy of sciences current issue

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Functional conservation despite structural divergence in ligand-responsive RNA switches [Biochemistry]

11-11-2014 | Mark A. Boerneke; Sergey M. Dibrov; Jing Gu; David L. Wyles; Thomas Hermann, Proceedings of the National Academy of Sciences current issue, 2014

An internal ribosome entry site (IRES) initiates protein synthesis in RNA viruses, including the hepatitis C virus (HCV). We have discovered ligand-responsive conformational switches in viral IRES elements. Modular RNA motifs of greatly distinct sequence and local secondary structure have been ...

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CDK5 activator protein p25 preferentially binds and activates GSK3{beta} [Neuroscience]

11-11-2014 | Hei-Man Chow; Dong Guo; Jie-Chao Zhou; Guan-Yun Zhang; Hui-Fang Li; Karl Herrup; Jie Zhang, Proceedings of the National Academy of Sciences current issue, 2014

Glycogen synthase kinase 3β (GSK3β) and cyclin-dependent kinase 5 (CDK5) are tau kinases and have been proposed to contribute to the pathogenesis of Alzheimer’s disease. The 3D structures of these kinases are remarkably similar, which led us to hypothesize that both might be capable of binding ...

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Giant cadherins Fat and Dachsous self-bend to organize properly spaced intercellular junctions [Cell Biology]

11-11-2014 | Yoshikazu Tsukasaki; Naoyuki Miyazaki; Atsushi Matsumoto; Shigenori Nagae; Shigenobu Yonemura; Takuji Tanoue; Kenji ..., Proceedings of the National Academy of Sciences current issue, 2014

The cadherins Fat and Dachsous regulate cell polarity and proliferation via their heterophilic interactions at intercellular junctions. Their ectodomains are unusually large because of repetitive extracellular cadherin (EC) domains, which raises the question of how they fit in regular ...

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A simple theoretical model goes a long way in explaining complex behavior in protein folding [Biophysics and Computational Biology]

11-11-2014 | Victor Muñoz, Proceedings of the National Academy of Sciences current issue, 2014

Understanding how natural proteins fold spontaneously onto their specific, biologically functional 3D structures is both a fascinating fundamental problem in modern biochemistry and a necessary step toward developing technologies for protein engineering and designing protein-based nanodevices. ...

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Size limits of self-assembled colloidal structures made using specific interactions [Physics]

11-11-2014 | Zorana Zeravcic; Vinothan N. Manoharan; Michael P. Brenner, Proceedings of the National Academy of Sciences current issue, 2014

We establish size limitations for assembling structures of controlled size and shape out of colloidal particles with short-ranged interactions. Through simulations we show that structures with highly variable shapes made out of dozens of particles can form with high yield, as long as each ...

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Inner Workings: Breaking down bees' dances [Inner Workings]

11-11-2014 | Helen H. Shen, Proceedings of the National Academy of Sciences current issue, 2014

Worker bees in the United Kingdom have taken a new job—collecting data for researchers at the University of Sussex. Margaret Couvillon and her colleagues have devised an environmental monitoring system that uses foraging honey bees and their “waggle” dances to measure land quality. The technique ...

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Antisense COOLAIR mediates the coordinated switching of chromatin states at FLC during vernalization [Plant Biology]

11-11-2014 | Tibor Csorba; Julia I. Questa; Qianwen Sun; Caroline Dean, Proceedings of the National Academy of Sciences current issue, 2014

Long noncoding RNAs (lncRNAs) have been proposed to play important roles in gene regulation. However, their importance in epigenetic silencing and how specificity is determined remain controversial. We have investigated the cold-induced epigenetic switching mechanism involved in the silencing of ...

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New approach to capture and characterize synaptic proteome [Neuroscience]

11-11-2014 | Xin-An Liu; Beena Kadakkuzha; Bruce Pascal; Caitlin Steckler; Komolitdin Akhmedov; Long Yan; Michael Chalmers; Sathy ..., Proceedings of the National Academy of Sciences current issue, 2014

Little is known regarding the identity of the population of proteins that are transported and localized to synapses. Here we describe a new approach that involves the isolation and systematic proteomic characterization of molecular motor kinesins to identify the populations of proteins ...

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Remodeling in bone without osteocytes: Billfish challenge bone structure-function paradigms [Evolution]

11-11-2014 | Ayelet Atkins; Mason N. Dean; Maria Laura Habegger; Phillip J. Motta; Lior Ofer; Felix Repp; Anna Shipov; Steve Wein ..., Proceedings of the National Academy of Sciences current issue, 2014

A remarkable property of tetrapod bone is its ability to detect and remodel areas where damage has accumulated through prolonged use. This process, believed vital to the long-term health of bone, is considered to be initiated and orchestrated by osteocytes, cells within the bone matrix. It is ...

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Activity-dependent PI(3,5)P2 synthesis controls AMPA receptor trafficking during synaptic depression [Neuroscience]

11-11-2014 | Amber J. McCartney; Sergey N. Zolov; Emily J. Kauffman; Yanling Zhang; Bethany S. Strunk; Lois S. Weisman; Michael A ..., Proceedings of the National Academy of Sciences current issue, 2014

Dynamic regulation of phosphoinositide lipids (PIPs) is crucial for diverse cellular functions, and, in neurons, PIPs regulate membrane trafficking events that control synapse function. Neurons are particularly sensitive to the levels of the low abundant PIP, phosphatidylinositol 3,5-bisphosphate ...

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