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15,804 Newest Publications in proceedings of the national academy of sciences current issue

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Occupation of bare habitats, an evolutionary precursor to soil specialization in plants [Evolution]

21-10-2014 | N. Ivalú Cacho; Sharon Y. Strauss, Proceedings of the National Academy of Sciences current issue, 2014

Plant soil specialists contribute greatly to global diversity; however, the ecoevolutionary forces responsible for generating this diversity are poorly understood. We integrate molecular phylogenies with descriptive and experimental ecological data, creating a powerful framework with which to ...

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Loss of p53 induces cell proliferation via Ras-independent activation of the Raf/Mek/Erk signaling pathway [Genetics]

21-10-2014 | Matthias Drosten; Eleanor Y. M. Sum; Carmen G. Lechuga; Lucía Simón-Carrasco; Harrys K. C. Jacob; Raquel García-Medi ..., Proceedings of the National Academy of Sciences current issue, 2014

The Ras family of small GTPases constitutes a central node in the transmission of mitogenic stimuli to the cell cycle machinery. The ultimate receptor of these mitogenic signals is the retinoblastoma (Rb) family of pocket proteins, whose inactivation is a required step to license cell ...

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Ultraefficient homogeneous catalyst for the CO2-to-CO electrochemical conversion [Chemistry]

21-10-2014 | Cyrille Costentin; Guillaume Passard; Marc Robert; Jean-Michel Savéant, Proceedings of the National Academy of Sciences current issue, 2014

A very efficient electrogenerated Fe0 porphyrin catalyst was obtained by substituting in tetraphenylporphyrin two of the opposite phenyl rings by ortho-, ortho'-phenol groups while the other two are perfluorinated. It proves to be an excellent catalyst of the CO2-to-CO conversion as to ...

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Genetically enhancing mitochondrial antioxidant activity improves muscle function in aging [Physiology]

21-10-2014 | Alisa Umanskaya; Gaetano Santulli; Wenjun Xie; Daniel C. Andersson; Steven R. Reiken; Andrew R. Marks, Proceedings of the National Academy of Sciences current issue, 2014

Age-related skeletal muscle dysfunction is a leading cause of morbidity that affects up to half the population aged 80 or greater. Here we tested the effects of increased mitochondrial antioxidant activity on age-dependent skeletal muscle dysfunction using transgenic mice with targeted ...

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Autism as a disorder of prediction [Neuroscience]

21-10-2014 | Pawan Sinha; Margaret M. Kjelgaard; Tapan K. Gandhi; Kleovoulos Tsourides; Annie L. Cardinaux; Dimitrios Pantazis; S ..., Proceedings of the National Academy of Sciences current issue, 2014

A rich collection of empirical findings accumulated over the past three decades attests to the diversity of traits that constitute the autism phenotypes. It is unclear whether subsets of these traits share any underlying causality. This lack of a cohesive conceptualization of the disorder has ...

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Role of pendant proton relays and proton-coupled electron transfer on the hydrogen evolution reaction by nickel hangman porphyrins [Chemistry]

21-10-2014 | D. Kwabena Bediako; Brian H. Solis; Dilek K. Dogutan; Manolis M. Roubelakis; Andrew G. Maher; Chang Hoon Lee; Matthe ..., Proceedings of the National Academy of Sciences current issue, 2014

The hangman motif provides mechanistic insights into the role of pendant proton relays in governing proton-coupled electron transfer (PCET) involved in the hydrogen evolution reaction (HER). We now show improved HER activity of Ni compared with Co hangman porphyrins. Cyclic voltammogram data and ...

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Gluconeogenesis in cancer: Door wide open [Biological Sciences]

21-10-2014 | Katharina Leithner; Andelko Hrzenjak; Horst Olschewski, Proceedings of the National Academy of Sciences current issue, 2014

Zhang et al. (1) make a valuable contribution to the field of cancer metabolism, showing that the tumor suppressor p53 down-regulates the gluconeogenic key enzyme phosphoenolpyruvate carboxykinase (PEPCK, PCK1) via histone deacetylase sirtuin 6. The authors conclude that inhibition of ...

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Tracking sustainable development with a national barometer for South Africa using a downscaled "safe and ȷust space" framework [Sustainability Science]

21-10-2014 | Megan J. Cole; Richard M. Bailey; Mark G. New, Proceedings of the National Academy of Sciences current issue, 2014

Nations in the 21st century face a complex mix of environmental and social challenges, as highlighted by the on-going Sustainable Development Goals process. The “planetary boundaries” concept [Rockström J, et al. (2009) Nature 461(7263):472–475], and its extension through the addition of social ...

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Computational design of a self-assembling symmetrical {beta}-propeller protein [Biophysics and Computational Biology]

21-10-2014 | Arnout R. D. Voet; Hiroki Noguchi; Christine Addy; David Simoncini; Daiki Terada; Satoru Unzai; Sam-Yong Park; Kam Y ..., Proceedings of the National Academy of Sciences current issue, 2014

The modular structure of many protein families, such as β-propeller proteins, strongly implies that duplication played an important role in their evolution, leading to highly symmetrical intermediate forms. Previous attempts to create perfectly symmetrical propeller proteins have failed, however. ...

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Multiple origins of serpentine-soil endemism explained by preexisting tolerance of open habitats [Evolution]

21-10-2014 | W. Scott Armbruster, Proceedings of the National Academy of Sciences current issue, 2014

Plant specialization on soils derived from unusual parent materials is an important contributor to regional biodiversity. These stressful substrates include serpentine, gabbro, and other ultramafic rocks rich in heavy metals. The effect of substrate on plant diversity is illustrated by serpentine ...

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