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16,351 Newest Publications in proceedings of the national academy of sciences current issue

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Deficiencies in tRNA synthetase editing activity cause cardioproteinopathy [Genetics]

09-12-2014 | Ye Liu; Jakob S. Satz; My-Nuong Vo; Leslie A. Nangle; Paul Schimmel; Susan L. Ackerman, Proceedings of the National Academy of Sciences current issue, 2014

Misfolded proteins are an emerging hallmark of cardiac diseases. Although some misfolded proteins, such as desmin, are associated with mutations in the genes encoding these disease-associated proteins, little is known regarding more general mechanisms that contribute to the generation of ...

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Innate sense of purpose for IKK{beta} [Biochemistry]

09-12-2014 | Matthew S. Hayden; Sankar Ghosh, Proceedings of the National Academy of Sciences current issue, 2014

The innate immune response is initiated upon recognition of pathogen-associated molecular patterns (PAMPs) by germ-line encoded pattern-recognition receptors (PRRs). PRRs including transmembrane receptors, typified by the Toll-like receptors (TLR) and cytoplasmic receptors, including the ...

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Acquisition of an immunosuppressive protumorigenic macrophage phenotype depending on c-Jun phosphorylation [Immunology and Inflammation]

09-12-2014 | Simona Hefetz-Sela; Ilan Stein; Yair Klieger; Rinnat Porat; Moshe Sade-Feldman; Farid Zreik; Arnon Nagler; Orit Papp ..., Proceedings of the National Academy of Sciences current issue, 2014

The inflamed tumor microenvironment plays a critical role in tumorigenesis. However, the mechanisms through which immune cells, particularly macrophages, promote tumorigenesis have only been partially elucidated, and the full scope of signaling pathways supplying macrophages with protumorigenic ...

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Young capillary vessels rejuvenate aged pancreatic islets [Medical Sciences]

09-12-2014 | Joana Almaça; Judith Molina; Rafael Arrojo e Drigo; Midhat H. Abdulreda; Won Bae Jeon; Per-Olof Berggren; Alejandro ..., Proceedings of the National Academy of Sciences current issue, 2014

Pancreatic islets secrete hormones that play a key role in regulating blood glucose levels (glycemia). Age-dependent impairment of islet function and concomitant dysregulation of glycemia are major health threats in aged populations. However, the major causes of the age-dependent decline of islet ...

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Phylogenetic reconstruction of Bantu kinship challenges Main Sequence Theory of human social evolution [Anthropology]

09-12-2014 | Christopher Opie; Susanne Shultz; Quentin D. Atkinson; Thomas Currie; Ruth Mace, Proceedings of the National Academy of Sciences current issue, 2014

Kinship provides the fundamental structure of human society: descent determines the inheritance pattern between generations, whereas residence rules govern the location a couple moves to after they marry. In turn, descent and residence patterns determine other key relationships such as alliance, ...

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Plasma DNA aberrations in systemic lupus erythematosus revealed by genomic and methylomic sequencing [Medical Sciences]

09-12-2014 | Rebecca W. Y. Chan; Peiyong Jiang; Xianlu Peng; Lai-Shan Tam; Gary J. W. Liao; Edmund K. M. Li; Priscilla C. H. Wong ..., Proceedings of the National Academy of Sciences current issue, 2014

We performed a high-resolution analysis of the biological characteristics of plasma DNA in systemic lupus erythematosus (SLE) patients using massively parallel genomic and methylomic sequencing. A number of plasma DNA abnormalities were found. First, aberrations in measured genomic ...

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Molecular architecture of the {alpha}{beta} T cell receptor-CD3 complex [Immunology and Inflammation]

09-12-2014 | Michael E. Birnbaum; Richard Berry; Yu-Shan Hsiao; Zhenjun Chen; Miguel A. Shingu-Vazquez; Xiaoling Yu; Deepa Waghra ..., Proceedings of the National Academy of Sciences current issue, 2014

αβ T-cell receptor (TCR) activation plays a crucial role for T-cell function. However, the TCR itself does not possess signaling domains. Instead, the TCR is noncovalently coupled to a conserved multisubunit signaling apparatus, the CD3 complex, that comprises the CD3εγ, CD3εδ, and CD3ζζ dimers. ...

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Whole-cell, multicolor superresolution imaging using volumetric multifocus microscopy [Applied Physical Sciences]

09-12-2014 | Bassam Hajj; Jan Wisniewski; Mohamed El Beheiry; Jiji Chen; Andrey Revyakin; Carl Wu; Maxime Dahan, Proceedings of the National Academy of Sciences current issue, 2014

Single molecule-based superresolution imaging has become an essential tool in modern cell biology. Because of the limited depth of field of optical imaging systems, one of the major challenges in superresolution imaging resides in capturing the 3D nanoscale morphology of the whole cell. Despite ...

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MAGUKs end a tale of promiscuity [Biochemistry]

09-12-2014 | Carsten Reissner; Markus Missler, Proceedings of the National Academy of Sciences current issue, 2014

Membrane-associated guanylate kinases (MAGUKs) constitute a family of scaffold molecules involved in diverse cellular processes, such as cell–cell communication, cell polarity, and signal transduction (1). MAGUKs are multidomain proteins with a core structure consisting of PSD-95/DLG/ZO-1 (PDZ), ...

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Elucidating severe urban haze formation in China [Environmental Sciences]

09-12-2014 | Song Guo; Min Hu; Misti L. Zamora; Jianfei Peng; Dongjie Shang; Jing Zheng; Zhuofei Du; Zhijun Wu; Min Shao; Limin Z ..., Proceedings of the National Academy of Sciences current issue, 2014

As the world’s second largest economy, China has experienced severe haze pollution, with fine particulate matter (PM) recently reaching unprecedentedly high levels across many cities, and an understanding of the PM formation mechanism is critical in the development of efficient mediation policies ...

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