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21,009 Newest Publications in proceedings of the national academy of sciences current issue

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Quantitative proteomics and phosphoproteomics on serial tumor biopsies from a sorafenib-treated HCC patient [Medical Sciences]

02-Feb-2016 | Eva Dazert; Marco Colombi; Tujana Boldanova; Suzette Moes; David Adametz; Luca Quagliata; Volker Roth; Luigi Terracc ..., Proceedings of the National Academy of Sciences current issue, 2016

Compensatory signaling pathways in tumors confer resistance to targeted therapy, but the pathways and their mechanisms of activation remain largely unknown. We describe a procedure for quantitative proteomics and phosphoproteomics on snap-frozen biopsies of hepatocellular carcinoma (HCC) and ...

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Transition state for the NSD2-catalyzed methylation of histone H3 lysine 36 [Biochemistry]

02-Feb-2016 | Myles B. Poulin; Jessica L. Schneck; Rosalie E. Matico; Patrick J. McDevitt; Michael J. Huddleston; Wangfang Hou; Ne ..., Proceedings of the National Academy of Sciences current issue, 2016

Nuclear receptor SET domain containing protein 2 (NSD2) catalyzes the methylation of histone H3 lysine 36 (H3K36). It is a determinant in Wolf–Hirschhorn syndrome and is overexpressed in human multiple myeloma. Despite the relevance of NSD2 to cancer, there are no potent, selective inhibitors of ...

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Extreme positive allometry of animal adhesive pads and the size limits of adhesion-based climbing [Evolution]

02-Feb-2016 | David Labonte; Christofer J. Clemente; Alex Dittrich; Chi-Yun Kuo; Alfred J. Crosby; Duncan J. Irschick; Walter Federle, Proceedings of the National Academy of Sciences current issue, 2016

Organismal functions are size-dependent whenever body surfaces supply body volumes. Larger organisms can develop strongly folded internal surfaces for enhanced diffusion, but in many cases areas cannot be folded so that their enlargement is constrained by anatomy, presenting a problem for larger ...

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Redundant function of DNA ligase 1 and 3 in alternative end-joining during immunoglobulin class switch recombination [Cell Biology]

02-Feb-2016 | Shahnaz Masani; Li Han; Katheryn Meek; Kefei Yu, Proceedings of the National Academy of Sciences current issue, 2016

Nonhomologous end-joining (NHEJ) is the major DNA double-strand break (DSB) repair pathway in mammals and resolves the DSBs generated during both V(D)J recombination in developing lymphocytes and class switch recombination (CSR) in antigen-stimulated B cells. In contrast to the absolute ...

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Enterovirus D68 receptor requirements unveiled by haploid genetics [Microbiology]

02-Feb-2016 | Jim Baggen; Hendrik Jan Thibaut; Jacqueline Staring; Lucas T. Jae; Yue Liu; Hongbo Guo; Jasper J. Slager; Jost W. de ..., Proceedings of the National Academy of Sciences current issue, 2016

Enterovirus D68 (EV-D68) is an emerging pathogen that can cause severe respiratory disease and is associated with cases of paralysis, especially among children. Heretofore, information on host factor requirements for EV-D68 infection is scarce. Haploid genetic screening is a powerful tool to ...

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Reply to Hart et al.: MINCR and MYC: More than expression correlation [Biological Sciences]

02-Feb-2016 | Gero Doose; Steve Hoffmann; Ingram Iaccarino, Proceedings of the National Academy of Sciences current issue, 2016

Based on novel correlation analyses in RNA-seq data from normal tissues and from Burkitt lymphoma (BL) cell lines, Hart et al. (1) suggest that MINCR is not a MYC-induced long noncoding (lnc) RNA. We thank the authors for providing additional analyses, but we do not think these data prove that...

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Common BRAF(V600E)-directed pathway mediates widespread epigenetic silencing in colorectal cancer and melanoma [Cell Biology]

02-Feb-2016 | Minggang Fang; Lloyd Hutchinson; April Deng; Michael R. Green, Proceedings of the National Academy of Sciences current issue, 2016

During cancer development, it is well established that many genes, including tumor suppressor genes, are hypermethylated and transcriptionally repressed, a phenomenon referred to as epigenetic silencing. In general, the factors involved in, and the mechanistic basis of, epigenetic silencing ...

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Multiscale model of light harvesting by photosystem II in plants [Biophysics and Computational Biology]

02-Feb-2016 | Kapil Amarnath; Doran I. G. Bennett; Anna R. Schneider; Graham R. Fleming, Proceedings of the National Academy of Sciences current issue, 2016

The first step of photosynthesis in plants is the absorption of sunlight by pigments in the antenna complexes of photosystem II (PSII), followed by transfer of the nascent excitation energy to the reaction centers, where long-term storage as chemical energy is initiated. Quantum mechanical ...

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GR SUMOylation and formation of an SUMO-SMRT/NCoR1-HDAC3 repressing complex is mandatory for GC-induced IR nGRE-mediated transrepression [Pharmacology]

02-Feb-2016 | Guoqiang Hua; Laetitia Paulen; Pierre Chambon, Proceedings of the National Academy of Sciences current issue, 2016

Unique among the nuclear receptor superfamily, the glucocorticoid (GC) receptor (GR) can exert three distinct transcriptional regulatory functions on binding of a single natural (cortisol in human and corticosterone in mice) and synthetic [e.g., dexamethasone (Dex)] hormone. The molecular ...

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Central auditory neurons have composite receptive fields [Neuroscience]

02-Feb-2016 | Andrei S. Kozlov; Timothy Q. Gentner, Proceedings of the National Academy of Sciences current issue, 2016

High-level neurons processing complex, behaviorally relevant signals are sensitive to conjunctions of features. Characterizing the receptive fields of such neurons is difficult with standard statistical tools, however, and the principles governing their organization remain poorly understood. ...

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