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18,881 Newest Publications in proceedings of the national academy of sciences current issue

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Novel protein Callipygian defines the back of migrating cells [Cell Biology]

21-Jul-2015 | Kristen F. Swaney; Jane Borleis; Pablo A. Iglesias; Peter N. Devreotes, Proceedings of the National Academy of Sciences current issue, 2015

Asymmetric protein localization is essential for cell polarity and migration. We report a novel protein, Callipygian (CynA), which localizes to the lagging edge before other proteins and becomes more tightly restricted as cells polarize; additionally, it accumulates in the cleavage furrow during ...

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Biased Brownian motion as a mechanism to facilitate nanometer-scale exploration of the microtubule plus end by a kinesin-8 [Biophysics and Computational Biology]

21-Jul-2015 | Yongdae Shin; Yaqing Du; Scott E. Collier; Melanie D. Ohi; Matthew J. Lang; Ryoma Ohi, Proceedings of the National Academy of Sciences current issue, 2015

Kinesin-8s are plus-end–directed motors that negatively regulate microtubule (MT) length. Well-characterized members of this subfamily (Kip3, Kif18A) exhibit two important properties: (i) They are “ultraprocessive,” a feature enabled by a second MT-binding site that tethers the motors to a MT ...

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Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart [Physiology]

21-Jul-2015 | Tyler P. Rasmussen; Yuejin Wu; Mei-ling A. Joiner; Olha M. Koval; Nicholas R. Wilson; Elizabeth D. Luczak; Qinchuan ..., Proceedings of the National Academy of Sciences current issue, 2015

Myocardial mitochondrial Ca2+ entry enables physiological stress responses but in excess promotes injury and death. However, tissue-specific in vivo systems for testing the role of mitochondrial Ca2+ are lacking. We developed a mouse model with myocardial delimited transgenic expression of a ...

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Insular neural system controls decision-making in healthy and methamphetamine-treated rats [Neuroscience]

21-Jul-2015 | Hiroyuki Mizoguchi; Kentaro Katahira; Ayumu Inutsuka; Kazuya Fukumoto; Akihiro Nakamura; Tian Wang; Taku Nagai; Jun ..., Proceedings of the National Academy of Sciences current issue, 2015

Patients suffering from neuropsychiatric disorders such as substance-related and addictive disorders exhibit altered decision-making patterns, which may be associated with their behavioral abnormalities. However, the neuronal mechanisms underlying such impairments are largely unknown. Using a ...

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Bacterial clonality and recombination [Colloquium Paper]

21-Jul-2015 | Louis-Marie Bobay; Charles C. Traverse; Howard Ochman, Proceedings of the National Academy of Sciences current issue, 2015

Bacteria reproduce asexually and pass on a single genome copied from the parent, a reproductive mode that assures the clonal descent of progeny; however, a truly clonal bacterial species is extremely rare. The signal of clonality can be interrupted by gene uptake and exchange, initiating ...

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Intergenerational neural mediators of early-life anxious temperament [Psychological and Cognitive Sciences]

21-Jul-2015 | Andrew S. Fox; Jonathan A. Oler; Alexander J. Shackman; Steven E. Shelton; Muthuswamy Raveendran; D. Reese McKay; Al ..., Proceedings of the National Academy of Sciences current issue, 2015

Understanding the heritability of neural systems linked to psychopathology is not sufficient to implicate them as intergenerational neural mediators. By closely examining how individual differences in neural phenotypes and psychopathology cosegregate as they fall through the family tree, we can ...

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EGFR inhibition evokes innate drug resistance in lung cancer cells by preventing Akt activity and thus inactivating Ets-1 function [Cell Biology]

21-Jul-2015 | Janyaporn Phuchareon; Frank McCormick; David W. Eisele; Osamu Tetsu, Proceedings of the National Academy of Sciences current issue, 2015

Nonsmall cell lung cancer (NSCLC) is the leading cause of cancer death worldwide. About 14% of NSCLCs harbor mutations in epidermal growth factor receptor (EGFR). Despite remarkable progress in treatment with tyrosine kinase inhibitors (TKIs), only 5% of patients achieve tumor reduction >90%. The ...

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How clonal are Neisseria species? The epidemic clonality model revisited [Colloquium Paper]

21-Jul-2015 | Michel Tibayrenc; Francisco J. Ayala, Proceedings of the National Academy of Sciences current issue, 2015

The three species Neisseria meningitidis, Neisseria gonorrheae, and Neisseria lactamica are often regarded as highly recombining bacteria. N. meningitidis has been considered a paradigmatic case of the “semiclonal model” or of “epidemic clonality,” demonstrating occasional bouts of clonal ...

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Yeast homologous recombination-based promoter engineering for the activation of silent natural product biosynthetic gene clusters [Microbiology]

21-Jul-2015 | Daniel Montiel; Hahk-Soo Kang; Fang-Yuan Chang; Zachary Charlop-Powers; Sean F. Brady, Proceedings of the National Academy of Sciences current issue, 2015

Large-scale sequencing of prokaryotic (meta)genomic DNA suggests that most bacterial natural product gene clusters are not expressed under common laboratory culture conditions. Silent gene clusters represent a promising resource for natural product discovery and the development of a new ...

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The EBF transcription factor Collier directly promotes Drosophila blood cell progenitor maintenance independently of the niche [Developmental Biology]

21-Jul-2015 | Billel Benmimoun; Cédric Polesello; Marc Haenlin; Lucas Waltzer, Proceedings of the National Academy of Sciences current issue, 2015

The maintenance of stem or progenitor cell fate relies on intrinsic factors as well as local cues from the cellular microenvironment and systemic signaling. In the lymph gland, an hematopoietic organ in Drosophila larva, a group of cells called the Posterior Signaling Centre (PSC), whose ...

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