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15,727 Newest Publications in proceedings of the national academy of sciences current issue

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Density-based separation in multiphase systems provides a simple method to identify sickle cell disease [Applied Physical Sciences]

14-10-2014 | Ashok A. Kumar; Matthew R. Patton; Jonathan W. Hennek; Si Yi Ryan Lee; Gaetana D’Alesio-Spina; Xiaoxi Yang; Julie Ka ..., Proceedings of the National Academy of Sciences current issue, 2014

Although effective low-cost interventions exist, child mortality attributable to sickle cell disease (SCD) remains high in low-resource areas due, in large part, to the lack of accessible diagnostic methods. The presence of dense (ρ > 1.120 g/cm3) cells is characteristic of SCD. The fluid, ...

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Selection of the lamprey VLRC antigen receptor repertoire [Immunology and Inflammation]

14-10-2014 | Stephen J. Holland; Mingming Gao; Masayuki Hirano; Lakshminarayan M. Iyer; Ming Luo; Michael Schorpp; Max D. Cooper; ..., Proceedings of the National Academy of Sciences current issue, 2014

The alternative adaptive immune system of jawless vertebrates is based on different isotypes of variable lymphocyte receptors (VLRs) that are composed of leucine-rich repeats (LRRs) and expressed by distinct B- and T-like lymphocyte lineages. VLRB is expressed by B-like cells, whereas VLRA and ...

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Tsc1 promotes the differentiation of memory CD8+ T cells via orchestrating the transcriptional and metabolic programs [Immunology and Inflammation]

14-10-2014 | Sharad Shrestha; Kai Yang; Jun Wei; Peer W. F. Karmaus; Geoffrey Neale; Hongbo Chi, Proceedings of the National Academy of Sciences current issue, 2014

Memory CD8+ T cells are an essential component of protective immunity. Signaling via mechanistic target of rapamycin (mTOR) has been implicated in the regulation of the differentiation of effector and memory T cells. However, little is understood about the mechanisms that control mTOR activity, ...

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Primate model offers insights into male bonding in complex societies [Anthropology]

14-10-2014 | Cyril C. Grueter, Proceedings of the National Academy of Sciences current issue, 2014

Primatological research is often conducted for the purpose of clarifying the evolutionary trajectories of behavioral and morphological characters that are either unique to humans or are shared with closely related species. Nonhuman primate species—especially those whose common ancestry is ...

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IKK phosphorylates RelB to modulate its promoter specificity and promote fibroblast migration downstream of TNF receptors [Cell Biology]

14-10-2014 | Hélène Authier; Katy Billot; Emmanuel Derudder; Didier Bordereaux; Pierre Rivière; Sylvie Rodrigues-Ferreira; Clara ..., Proceedings of the National Academy of Sciences current issue, 2014

TNFα is a potent cytokine that plays a critical role in numerous cellular processes, particularly immune and inflammatory responses, programmed cell death, angiogenesis, and cell migration. Thus, understanding the molecular mechanisms that mediate TNFα-induced cellular responses is a crucial ...

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Memory trace and timing mechanism localized to cerebellar Purkinje cells [Neuroscience]

14-10-2014 | Fredrik Johansson; Dan-Anders Jirenhed; Anders Rasmussen; Riccardo Zucca; Germund Hesslow, Proceedings of the National Academy of Sciences current issue, 2014

The standard view of the mechanisms underlying learning is that they involve strengthening or weakening synaptic connections. Learned response timing is thought to combine such plasticity with temporally patterned inputs to the neuron. We show here that a cerebellar Purkinje cell in a ferret can ...

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Rice SPX1 and SPX2 inhibit phosphate starvation responses through interacting with PHR2 in a phosphate-dependent manner [Plant Biology]

14-10-2014 | Zhiye Wang; Wenyuan Ruan; Jing Shi; Li Zhang; Dan Xiang; Chao Yang; Changying Li; Zhongchang Wu; Yu Liu; Yanan Yu; H ..., Proceedings of the National Academy of Sciences current issue, 2014

In plants, sensing the levels of external and internal nutrients is essential for reprogramming the transcriptome and adapting to the fluctuating environment. Phosphate (Pi) is a key plant nutrient, and a large proportion of Pi starvation-responsive genes are under the control of PHOSPHATE ...

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ICAM-1 as a molecular target for triple negative breast cancer [Medical Sciences]

14-10-2014 | Peng Guo; Jing Huang; Liya Wang; Di Jia; Jiang Yang; Deborah A. Dillon; David Zurakowski; Hui Mao; Marsha A. Moses; ..., Proceedings of the National Academy of Sciences current issue, 2014

Triple negative breast cancers (TNBCs) have a high mortality rate owing to aggressive proliferation and metastasis and a lack of effective therapeutic options. Herein, we describe the overexpression of intercellular adhesion molecule-1 (ICAM-1) in human TNBC cell lines and tissues, and ...

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Caenorhabditis elegans RSD-2 and RSD-6 promote germ cell immortality by maintaining small interfering RNA populations [Genetics]

14-10-2014 | Aisa Sakaguchi; Peter Sarkies; Matt Simon; Anna-Lisa Doebley; Leonard D. Goldstein; Ashley Hedges; Kohta Ikegami; St ..., Proceedings of the National Academy of Sciences current issue, 2014

Germ cells are maintained in a pristine non-aging state as they proliferate over generations. Here, we show that a novel function of the Caenorhabditis elegans RNA interference proteins RNAi spreading defective (RSD)-2 and RSD-6 is to promote germ cell immortality at high temperature. rsd mutants ...

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MAGI-2 scaffold protein is critical for kidney barrier function [Medical Sciences]

14-10-2014 | Minna D. Balbas; Michael R. Burgess; Rajmohan Murali; John Wongvipat; Brian J. Skaggs; Peter Mundel; Astrid Weins; C ..., Proceedings of the National Academy of Sciences current issue, 2014

MAGUK Inverted 2 (MAGI-2) is a PTEN-interacting scaffold protein implicated in cancer on the basis of rare, recurrent genomic translocations and deletions in various tumors. In the renal glomerulus, MAGI-2 is exclusively expressed in podocytes, specialized cells forming part of the glomerular ...

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