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19,302 Newest Publications in proceedings of the national academy of sciences current issue

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Thermophilization of adult and juvenile tree communities in the northern tropical Andes [Ecology]

25-Aug-2015 | Alvaro Duque; Pablo R. Stevenson; Kenneth J. Feeley, Proceedings of the National Academy of Sciences current issue, 2015

Climate change is expected to cause shifts in the composition of tropical montane forests towards increased relative abundances of species whose ranges were previously centered at lower, hotter elevations. To investigate this process of “thermophilization,” we analyzed patterns of compositional ...

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Reply to Luo et al.: Robustness of causal effects of galactic cosmic rays on interannual variation in global temperature [Physical Sciences]

25-Aug-2015 | Hao Ye; George Sugihara; Ethan R. Deyle; Robert M. May; Kyle Swanson; Anastasios A. Tsonis, Proceedings of the National Academy of Sciences current issue, 2015

Tsonis et al. (1) recently used convergent cross mapping (CCM) (2) to identify a causal relationship between cosmic rays (CRs) and interannual variation in global temperature (ΔGT). Subsequently, Luo et al. (3) questioned this finding using the Clark implementation of CCM (version 1.0 of the ...

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Microfluidic screening and whole-genome sequencing identifies mutations associated with improved protein secretion by yeast [Applied Biological Sciences]

25-Aug-2015 | Mingtao Huang; Yunpeng Bai; Staffan L. Sjostrom; Björn M. Hallström; Zihe Liu; Dina Petranovic; Mathias Uhlén; Haaka ..., Proceedings of the National Academy of Sciences current issue, 2015

There is an increasing demand for biotech-based production of recombinant proteins for use as pharmaceuticals in the food and feed industry and in industrial applications. Yeast Saccharomyces cerevisiae is among preferred cell factories for recombinant protein production, and there is increasing ...

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Highly efficient nonprecious metal catalyst prepared with metal-organic framework in a continuous carbon nanofibrous network [Engineering]

25-Aug-2015 | Jianglan Shui; Chen Chen; Lauren Grabstanowicz; Dan Zhao; Di-Jia Liu, Proceedings of the National Academy of Sciences current issue, 2015

Fuel cell vehicles, the only all-electric technology with a demonstrated >300 miles per fill travel range, use Pt as the electrode catalyst. The high price of Pt creates a major cost barrier for large-scale implementation of polymer electrolyte membrane fuel cells. Nonprecious metal catalysts ...

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Antibodies targeting human IL1RAP (IL1R3) show therapeutic effects in xenograft models of acute myeloid leukemia [Medical Sciences]

25-Aug-2015 | Helena Ågerstam; Christine Karlsson; Nils Hansen; Carl Sandén; Maria Askmyr; Sofia von Palffy; Carl Högberg; Mariann ..., Proceedings of the National Academy of Sciences current issue, 2015

Acute myeloid leukemia (AML) is associated with a poor survival rate, and there is an urgent need for novel and more efficient therapies, ideally targeting AML stem cells that are essential for maintaining the disease. The interleukin 1 receptor accessory protein (IL1RAP; IL1R3) is expressed on ...

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Systems biology definition of the core proteome of metabolism and expression is consistent with high-throughput data [Systems Biology]

25-Aug-2015 | Laurence Yang; Justin Tan; Edward J. O’Brien; Jonathan M. Monk; Donghyuk Kim; Howard J. Li; Pep Charusanti; Ali Ebra ..., Proceedings of the National Academy of Sciences current issue, 2015

Finding the minimal set of gene functions needed to sustain life is of both fundamental and practical importance. Minimal gene lists have been proposed by using comparative genomics-based core proteome definitions. A definition of a core proteome that is supported by empirical data, is understood ...

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Fmr1 deficiency promotes age-dependent alterations in the cortical synaptic proteome [Applied Biological Sciences]

25-Aug-2015 | Bin Tang; Tingting Wang; Huida Wan; Li Han; Xiaoyan Qin; Yaoyang Zhang; Jian Wang; Chunlei Yu; Fulvia Berton; Walter ..., Proceedings of the National Academy of Sciences current issue, 2015

Fragile X syndrome (FXS) is an X-linked neurodevelopmental disorder characterized by severe intellectual disability and other symptoms including autism. Although caused by the silencing of a single gene, Fmr1 (fragile X mental retardation 1), the complexity of FXS pathogenesis is amplified ...

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Quantifying the impact of weak, strong, and super ties in scientific careers [Social Sciences]

25-Aug-2015 | Alexander Michael Petersen, Proceedings of the National Academy of Sciences current issue, 2015

Scientists are frequently faced with the important decision to start or terminate a creative partnership. This process can be influenced by strategic motivations, as early career researchers are pursuers, whereas senior researchers are typically attractors, of new collaborative opportunities. ...

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Quantitative genomic analysis of RecA protein binding during DNA double-strand break repair reveals RecBCD action in vivo [Cell Biology]

25-Aug-2015 | Charlotte A. Cockram; Milana Filatenkova; Vincent Danos; Meriem El Karoui; David R. F. Leach, Proceedings of the National Academy of Sciences current issue, 2015

Understanding molecular mechanisms in the context of living cells requires the development of new methods of in vivo biochemical analysis to complement established in vitro biochemistry. A critically important molecular mechanism is genetic recombination, required for the beneficial reassortment ...

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Examining the reaction of NO and H2S and the possible cross-talk between the two signaling pathways [Chemistry]

25-Aug-2015 | Christopher L. Bianco; Jon M. Fukuto, Proceedings of the National Academy of Sciences current issue, 2015

Small Molecule Signaling The small, low molecular weight molecules nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S) are all endogenously generated in mammalian systems via regulated enzymatic catalysis (1). Along with dioxygen (O2), these small molecules, as well as their ...

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