22-05-2013 | Mease, Ronnie C.; Foss, Catherine A.; Pomper, Martin G., Current Topics in Medicinal Chemistry, 2013

Abstract: Prostate cancer (PCa) is the second leading cause of cancer-related death in American men. Positron emission tomography/computed tomography (PET/CT) with emerging radiopharmaceuticals promises accurate staging of primary disease, restaging of recurrent disease, detection of ...

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22-05-2013 | Jarkas, Nashwa, Current Topics in Medicinal Chemistry, 2013

Abstract: Diaryl sulfides also known as diphenyl sulfides, phenylthiobenzylamines, and biphenylthiols are a class of compounds with phenylthiophenyl scaffold that have been validated as biomarkers to label the brain serotonin transporter (SERT), in vivo. The development of those ...

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22-05-2013 | Stehouwer, Jeffrey S., Current Topics in Medicinal Chemistry, 2013

Abstract: The development of tropane-derivatives as cocaine-addiction therapeutics identified numerous compounds with affinities for the dopamine, serotonin, and norepinephrine transporters. Many of these compounds were then adapted for use as imaging radiotracers. Incorporation of ...

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22-05-2013 | Mun, Jiyoung, Current Topics in Medicinal Chemistry, 2013

Abstract: 2-Deoxy-2-[18F]fluoro-D-glucose (2-18FDG) has represented radiofluorinated carbohydrates as the most successful tracer for positron emission tomography (PET). 2-18FDG uptake depends on glucose metabolism, which is related to a disease progression. 2-18FDG has been widely used ...

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22-05-2013 | Sai, Kiran Kumar Solingapuram; Jones, Lynne A.; Mach, Robert H., Current Topics in Medicinal Chemistry, 2013

Abstract: In recent years, two different methods have been developed to image cell proliferation with the functional imaging technique, Positron emission Tomography (PET), proliferation rate and proliferative status. Proliferation rate is a measure of the tumor doubling time and uses ...

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22-05-2013 | Zeng, Fanxing; Goodman, Mark M., Current Topics in Medicinal Chemistry, 2013

Abstract: Alzheimer's disease (AD), the most common form of dementia, is a progressive and fatal neurodegenerative disorder. The neuropathological hallmarks of AD generally revealed on postmortem brain tissue are the extracellular neuritic plaque deposits and intracellular ...

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22-05-2013 | Huang, Chaofeng; McConathy, Jonathan, Current Topics in Medicinal Chemistry, 2013

Abstract: 18F-labeled amino acids are an important class of imaging agents for positron emission tomography (PET) that target the increased rates of amino acid transport by many tumor cells. This class of tracers is structurally diverse, and the biological and imaging properties of a ...

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15-05-2013 | Gomara, Maria J.; Haro, Isabel, Current Topics in Medicinal Chemistry, 2013

Abstract: Antibodies directed against citrullinated proteins and peptides (ACPAs) are the most specific serological markers available for diagnosing rheumatoid arthritis (RA). ACPAs may be detected several years before symptoms of RA appear, and their presence at disease onset is a ...

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15-05-2013 | Chen, Mingzhen; Zhang, Fang; Li, HeXing, Organic Chemistry, 2013

Abstract: A novel Pd(II) organometallic catalyst bonded to magnetic SiO2@Fe3O4 support was synthesized by coordinating Pd(II) with the PPh2-ligand originally grafted onto the silica layer covering the Fe3O4 microspheres. Owing to the high dispersion of Pd(II) active sites, the ...

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15-05-2013 | Sanmarti, Raimon; Ruiz-Esquide, Virginia; Hernandez, Maria Victoria, Current Topics in Medicinal Chemistry, 2013

Abstract: Rheumatoid arthritis (RA) is the most frequent form of chronic polyarthritis, affecting 0.5-1% of adults worldwide. In recent years there have been important advances in the pathogenesis of RA, together with new diagnostic and therapeutic insights. Early diagnosis is ...

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