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782 Newest Publications of de Gruyter

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Review: The hCG assay or pregnancy test

13-12-2011 | Laurence A. Cole, Clinical Chemistry , 2011

Abstract This review examines human chorionic gonadotropin (hCG) or pregnancy tests from multiple perspectives. It first investigates the molecule hCG and shows that the term represents five independent molecules differing in carbohydrate and meric structure that share a common amino acid ...

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Monitoring quality indicators in laboratory medicine does not automatically result in quality improvement

13-12-2011 | Laura Sciacovelli; Oswald Sonntag; Andrea Padoan; Carlo Federico Zambon; Paolo Carraro; Mario Plebani, Clinical Chemistry , 2011

Abstract Background: Data on quality indicators (QIs) should be collected over time in order to identify and continuously monitor clinical laboratory performance and to improve patient safety by identifying and implementing effective interventions. The aim of the present study was to ascertain ...

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Soluble transcobalamin receptor, sCD320, is present in human serum and relates to serum cobalamin – establishment and validation of an ELISA

13-12-2011 | Johan Frederik Berg Arendt; Edward V. Quadros; Ebba Nexo, Clinical Chemistry , 2011

Abstract Background: The cell-surface receptor, TCblR/CD320, binds and internalizes transcobalamin-bound cobalamin. So far, no assay has been developed in order to quantify the soluble form of the receptor. Methods: This study developed an ELISA employing a monoclonal antibody that recognized the ...

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A comparative analysis of the Iris iQ200 with manual microscopy as a diagnostic tool for dysmorphic erythrocytes in urine

13-12-2011 | Leonie A. Boven; Hans Kemperman; Ayşe Y. Demir, Clinical Chemistry , 2011

Clinical Chemistry and Laboratory Medicine, Volume 0, Issue 0, Page -, Ahead of Print.

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Comparison of different collection procedures and two methods for DNA isolation from saliva

13-12-2011 | Jaroslava Durdiaková; Natália Kamodyová; Daniela Ostatníková; Barbora Vlková; Pete ..., Clinical Chemistry , 2011

Abstract Background: The non-invasive, flexible and easy sample collection makes saliva an interesting source of DNA for research and diagnostic purposes. The aim of our study was to find the most suitable collection method for biological material from the oral cavity and the most effective DNA ...

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Faecal haemoglobin concentrations by gender and age: implications for population-based screening for colorectal cancer

13-12-2011 | Paula J. McDonald; Judith A. Strachan; Jayne Digby; Robert J.C. Steele; Callum G. Fraser, Clinical Chemistry , 2011

Abstract Background: Faecal immunochemical tests (FIT) are becoming widely used in colorectal cancer screening. Estimation of faecal haemoglobin concentration in a large group prompted an observational study on gender and age. Methods: A single estimate of faecal haemoglobin concentration was ...

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Low angle light scattering analysis: a novel quantitative method for functional characterization of human and murine platelet receptors

13-12-2011 | Igor Mindukshev; Stepan Gambaryan; Linda Kehrer; Claudia Schuetz; Anna Kobsar; Natalia Rukoyatkina; Viacheslav ..., Clinical Chemistry , 2011

Abstract Background: Determinations of platelet receptor functions are indispensable diagnostic indicators of cardiovascular and hemostatic diseases including hereditary and acquired receptor defects and receptor responses to drugs. However, presently available techniques for assessing platelet ...

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Ultrasound markers for the detection of women at risk of developing pre-eclampsia

13-12-2011 | Guillaume Macé; Evelyne Cynober; Bruno Carbonne, Clinical Chemistry , 2011

Abstract Pre-eclampsia (PE) is a consequence of an abnormal placental invasion. Uterine artery Doppler (Ut-AD) is directly related to trophoblastic invasion of the spiral arteries, which occurs before 18 weeks’ gestation. A correct interpretation of Ut-AD indices and waveform patterns requires a ...

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Serum concentration of neopterin on admission does not improve the diagnostic performance of highly-sensitive troponin I

13-12-2011 | Martina Montagnana; Giuseppe Lippi; Elisa Danese; Gian Luca Salvagno; Gianfranco Cervellin; Gian Cesare Guidi, Clinical Chemistry , 2011

Clinical Chemistry and Laboratory Medicine, Volume 0, Issue 0, Page -, Ahead of Print.

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Recent progress and clinical importance on pharmacogenetics in cancer therapy

19-10-2011 | Thomas I. Peng Soh; Wei Peng Yong; Federico Innocenti, Clinical Chemistry , 2011

Abstract Recent advances have provided unprecedented opportunities to identify prognostic and predictive markers of efficacy of cancer therapy. Genetic markers can be used to exclude patients who will not benefit from therapy, exclude patients at high risk of severe toxicity and adjust dosing. ...

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