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39 Newest Publications of de Gruyter

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The significance of the Cα substituent in the selective inhibition of matrix metalloproteinases 1 and 9

06-10-2011 | Riyad Domingo; Kelly Chibale; Edward D. Sturrock, Biological Chemistry, 2011

Abstract Matrix metalloproteinases (MMPs) cleave and degrade most components of the extracellular matrix, and unregulated MMP activity has been correlated to cancer and metastasis. Hence there is a burgeoning need to develop inhibitors that bind selectively to structurally similar MMPs. The ...

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Monitoring of mycophenolic acid and kidney function during combined immunosuppressive therapy

18-08-2011 | Anna V. Oláh; László Asztalos; Gergely Ivády; Éva Varga; Ágota M. Kovács; J& ..., Clinical Chemistry , 2011

Abstract Background: Mycophenolic acid (MPA), a selective inhibitor of lymphocyte proliferation, has lately been used to improve renal function and prolong graft survival in renal transplanted patients. Still, there is no consensus considering the recommended dosing and the therapeutic range of ...

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Comparative evaluation of capillary zone electrophoresis and HPLC in the determination of carbohydrate-deficient transferrin

13-06-2011 | Massimo Daves; Roberto Cemin; Mirella Floreani; Irene Pusceddu; Giovanni Cosio; Giuseppe Lippi, Clinical Chemistry , 2011

Abstract Background: Transferrin (Tf) glycoform lacking one or two complete or incomplete glycan chains (i.e., asialo-monosialo- and disialo-Tf) typically appear in blood after chronic alcohol consumption, though recently it was reported that monosialo-Tf is associated with trisialo-Tf but not ...

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The function of oxalic acid in the human metabolism

01-06-2011 | Daniel Stewart Robertson, Clinical Chemistry , 2011

Abstract Biochemical reactions in cells which involve oxalic acid are described. It is shown that this compound is required for the formation of uracil and orotic acid. The former is a component of RNA which is common to all cells in the human metabolism. On the basis of the biochemical reactions ...

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Reference intervals and age and gender dependency for arterial blood gases and electrolytes in adults

27-05-2011 | Elise Klæstrup; Torleif Trydal; Jan F. Pedersen; Jacob M. Larsen; Søren Lundbye-Christensen; Sør ..., Clinical Chemistry , 2011

Abstract Background: Although results from blood gas analyzers are frequently used in clinical work surprisingly few and small studies have examined reference intervals for arterial blood gases and acid-base status. We have established reference values based on a large group of healthy people ...

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Investigating the effects of physiological bile acids on GLP-1 secretion and glucose tolerance in normal and GLP-1R-/- mice

23-05-2011 | Eamon P. Rafferty; Alastair R. Wylie; Katharine H. Hand; Chris E. Elliott; David J. Grieve; Brian D. Green, Biological Chemistry, 2011

Abstract Physiological secretion of bile acids has previously been linked to the regulation of blood glucose. GLP-1 is an intestinal peptide hormone with important glucose-lowering actions, such as stimulation of insulin secretion and inhibition of glucagon secretion. In this investigation, we ...

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Allele-selective inhibition of ataxin-3 (ATX3) expression by antisense oligomers and duplex RNAs

23-05-2011 | Jiaxin Hu; Keith T. Gagnon; Jing Liu; Jonathan K. Watts; Jeja Syeda-Nawaz; C. Frank Bennett; Eric E. Swayze; ..., Biological Chemistry, 2011

Abstract Spinocerebellar ataxia-3 (also known as Machado-Joseph disease) is an incurable neurodegenerative disorder caused by expression of a mutant variant of ataxin-3 (ATX3) protein. Inhibiting expression of ATX3 would provide a therapeutic strategy, but indiscriminant inhibition of both ...

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Myeloperoxidase-catalyzed oxidative inactivation of human kininogens: the impairment of kinin-precursor and prekallikrein-binding functions

23-05-2011 | Andrzej Kozik; Anna Golda; Pawel Mak; Piotr Suder; Jerzy Silberring; Anna Barbasz; Maria Rapala-Kozik, Biological Chemistry, 2011

Abstract Bradykinin-related vasoactive peptides (kinins) are important mediators of local and systemic inflammatory reactions. However, at local inflammatory foci, the production of kinins from proteinaceous precursors (kininogens) can be affected by reactive oxygen species released by phagocyte ...

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A simple liquid chromatography-tandem mass spectrometry method for measuring metanephrine and normetanephrine in urine

17-05-2011 | Jessica Gabler; Abby Miller; Sihe Wang, Clinical Chemistry , 2011

Abstract Background: Measuring urinary fractionated metanephrines is one of the initial tests in the diagnosis of pheochromocytoma. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) represents the most specific and accurate technology for this purpose. The goal of this work was to develop ...

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Diagnostic efficiency of truncated area under the curve from 0 to 2 h (AUC0–2) of mycophenolic acid in kidney transplant recipients receiving mycophenolate mofetil and concomitant tacrolimus

17-05-2011 | Natalia Lampón; María J. Tutor-Crespo; Rafael Romero; José C. Tutor, Clinical Chemistry , 2011

Abstract Background: Recently, the use of the truncated area under the curve from 0 to 2h (AUC0–2) of mycophenolic acid (MPA) has been proposed for therapeutic monitoring in liver transplant recipients. The aim of our study was the evaluation of the clinical usefulness of truncated AUC0–2 in ...

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